The effect of the ischaemic compression technique on pain and functionality in temporomandibular disorders: A randomised clinical trial

Greek DailyNews shared this article with you from Inoreader The effect of the ischaemic compression technique on pain and functionality in temporomandibular disorders: A randomised clinical trial Via Journal of Oral Rehabilitation Abstract Background Interventions addressing pain and impaired functionality in individuals with temporomandibular disorders (TMDs) are needed. Objective To compare the effects of 4 weeks of exercise combined with ischaemic compression and exercise alone in patients with TMDs. Methods Fifty patients who were diagnosed with TMDs were randomised into Group 1 (exercise combined with ischaemic compression technique) (n = 25) or Group 2 (exercise alone) (n = 25). Both groups performed 4 weeks of Rocabado's exercise and 3 weeks of postural exercise, while Group 1 received ischaemic compression to the masseter muscle for a total of 3 sessions in addition to exercise. A ruler was used to assess range of motion (ROM) (painless mouth opening (PMO), maximum mouth opening, maximum assisted mouth opening (MAMO), left lateral movement and right lateral movement), the visual analogue scale and graded chronic pain scale were used to assess pain, an algometer was used to determine the pain pressure threshold (PPT), and the 8‐item jaw functional limitation scale was used to assess, functionality. The assessments were performed at baseline, at week 1 and at week 4. Results The participants in Group 1 exhibited larger PMO (F = 5.26, P = .02) and MAMO values (F = 6.71, P = .01) than did the patients in Group 2 at week 1. The effect size was small for MAMO (ES = 0.27) and moderate for PMO (ES = 0.51). However, there were no significant differences in any other outcomes between groups at week 1 or 4. Conclusion In summary, this randomised controlled trial indicates that exercise combined with ICT and exercise alone have similar effects on ROM, pain, the PPT and functionality in patients with TMDs. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Changes of bolus properties and the triggering of swallowing in healthy humans

Greek DailyNews shared this article with you from Inoreader Changes of bolus properties and the triggering of swallowing in healthy humans Via Journal of Oral Rehabilitation Abstract Background There is wide variation in chewing behaviors, even among healthy humans. Further, the way in which humans determine swallowing initiation when chewing solid foods remains unclear. The current study sought to investigate how the bolus properties change over time during chewing, and to clarify which factors affect chewing and swallowing behaviors, including swallowing initiation, in healthy humans. Methods Twenty‐four healthy volunteers were instructed to chew 8 g of steamed rice and spit it out at 50%, 100% and 150% of their own chewing duration, defined as the time of chewing from onset of the first chewing cycle to onset of the first swallow. Chewing and swallowing behaviors were monitored and determined by visual inspection of video recordings. The physical properties such as hardness, cohesiveness and adhesiveness as well as water content of the bolus were measured. In each subject, maximum bite force, tongue pressure, and stimulated salivary flow rate were also measured. Results Hardness gradually decreased, and the cohesiveness and water content of the bolus did not change up to 50% of chewing duration, followed by a slight but significant increase. The adhesiveness of the bolus rapidly decreased at the beginning of chewing. Chewing duration was significantly related to stimulated salivary flow rate; greater salivary flow rate was associated with shorter chewing duration. Conclusion Variation of chewing duration and swallowing initiation was not dependent on bolus properties during the chewing of steamed rice, but mainly depended on the surface lubrication of the bolus. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Construction of virtual intercuspal occlusion: considering tooth displacement

Greek DailyNews shared this article with you from Inoreader Construction of virtual intercuspal occlusion: considering tooth displacement Via Journal of Oral Rehabilitation Abstract Background Common impressions cannot accurately duplicate the dental occlusion under occlusal force due to tooth displacement and mandibular deformation. Aims To establish new methods to construct virtual intercuspal occlusion and assess their construction accuracy. Methods The intraoral occlusal contacts of posterior teeth of 15 subjects were recorded with 8 μm and 100 μm articulating paper respectively, and the marked teeth and buccal bite data were scanned with an intraoral scanner. The virtual dental occlusions were separately determined by buccal bite registration (BBR) method, and 3 new methods, namely segmented tooth registration (STR), occlusal contact areas (marked by 8 μm articulating paper) registration (OCR) and mixing registration (MR) methods. With the intraoral contact areas marked by 100 μm articulating paper set as reference and contact areas of the 4 virtual occlusion as tests, sensitivity, positive predictive value (PPV), and the ratio of overlapping areas were calculated. Kruskal‐Wallis test or 1‐way ANOVA was used to analyze the difference among groups. Results The sensitivity ranged from 0.69 to 0.94 and the PPV from 0.67 to 0.90. Sensitivity of OCR group and PPV of STR and OCR groups were different from that of BBR group at overlapping threshold of 50% (P=.028, .028, and .006). There was statistical difference of the ratio of overlapping areas over reference areas, and the values of STR and OCR groups were higher than that of BBR group (P=.045 and .021). Conclusion The ability of STR and OCR methods to construct virtual intercuspal occlusion were better than BBR method. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effects of sitting posture and jaw clenching on neck and trunk muscle activities during typing

Greek DailyNews shared this article with you from Inoreader Effects of sitting posture and jaw clenching on neck and trunk muscle activities during typing Via Journal of Oral Rehabilitation Abstract Background Neck pain is one of the most common musculoskeletal complaints. Evidence suggests that increased activities of neck and trunk muscles are one of the mechanisms related to neck pain. Jaw clenching and sitting posture may modulate the muscle activity in neck and trunk muscles during typing. Objective The present study aimed to assess the effects of different postural positions and clenching conditions on neck and trunk muscle activities. Methods Thirteen healthy adults (39.8 ± 5.0 years) performed computer typing tasks in four conditions (two postural positions [upright vs. slouched] and two jaw clenching conditions [clenching vs. non‐clenching]). Integrated surface electromyography (iEMG) was measured in sternocleidomastoid (SCM), upper trapezius (uTP), and middle trapezius (mTP) muscles and compared between conditions. Friedman and Wilcoxon signed‐rank tests with Bonferroni corrections were used to estimate the condition‐specific differences in the iEMG data. The statistical significance level was set at 5%. Results In both postural positions, iEMGSCM was significantly greater under the jaw clenching than under the non‐clenching condition (χ2 = 21.700, p < 0.01). Under both jaw clenching conditions, iEMGuTP was significantly greater in the slouched than in the upright postural position (χ2 = 23.182, p < 0.01). No significant differences in iEMGmTP were seen across conditions (χ2 = 5.018, p = 0.10). Conclusion Sitting posture and jaw clenching appear to influence activities of different muscles. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Association between declines in objective masticatory performance and salivary stress markers: The Suita study

Greek DailyNews shared this article with you from Inoreader Association between declines in objective masticatory performance and salivary stress markers: The Suita study Via Journal of Oral Rehabilitation Abstract Dentists often encounter patients suffering from psychological and social stress due to declines in masticatory performance, making this a critical issue to manage. We aimed to clarify the relationships between salivary stress markers as objective indices of chronic stress and objective masticatory performance in a general urban Japanese population. Data from 880 participants (mean age, 65.8 years) in the Suita study were used. Salivary interleukin (IL)‐6 and cortisol concentrations were measured by enzyme‐linked immunosorbent assay. Objective masticatory performance was determined by measuring the increase in surface area test gummy jelly after 30 times chewing. Participants were divided into two groups based on masticatory performance: a decreased group (lowest quartile) and a non‐decreased group (second to fourth quartiles). Odds ratios (ORs) of higher salivary levels of stress markers (highest quartile) according to masticatory performance were estimated using logis tic regression analysis adjusting for age, sex, periodontal status, salivary flow rate and smoking habit. Salivary IL‐6 level was significantly higher in the decreased group than in the non‐decreased group. Logistic regression analysis showed the adjusted OR for higher salivary IL‐6 was significantly higher in the decreased group than in the non‐decreased group (OR = 1.92; 95% confidence interval = 1.33‐2.76; P < .001). No significant associations were found between salivary cortisol and decreased masticatory performance in any analyses. Declines in objective masticatory performance may correlate with higher salivary IL‐6 level as an objective index of chronic stress. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Can masticatory performance be predicted by using food acceptance questionnaire in elderly patients with removable dentures?

Greek DailyNews shared this article with you from Inoreader Can masticatory performance be predicted by using food acceptance questionnaire in elderly patients with removable dentures? Via Journal of Oral Rehabilitation Abstract Background Although a food acceptance questionnaire is useful for subjective masticatory function assessments, its characteristics and limitations when applied to patients with removable dentures have been unclear. We therefore assessed the relationship between the subjective and objective masticatory function and explored whether or not a decreased masticatory function could be evaluated by food acceptance questionnaire. Methods One hundred and nineteen patients >60 years old with removable partial and/or complete dentures participated. Food acceptance score (FAS) was calculated by using Sato's questionnaire with 20 food items. Masticatory performance (MP) was assessed by a visual scoring method using a test gummy jelly (UHA Mikakuto). Simple/multiple regression analyses were performed to explain the objective masticatory function. The cut‐off value of FAS was determined to predict a decreased masticatory function by sensitivity, specificity and receiver operating characteristics curve. Results No significant gender differences in MP or FAS were noted. Although both MP and FAS increased with the number of functional teeth, FAS was not significantly affected by age. The number of functional teeth, FAS and age had significant correlations with MP, with the number of functional teeth showing the strongest correlation. Multiple linear regression analyses identified the FAS as a significant explanatory variable for MP, and 70 was the optimal cut‐off value for detecting a decreased masticatory function (MP score ≤ 2) in the diagnosis of 'oral hypofunction'. Conclusions Using FAS to assess the MP was deemed appropriate, and a score of 70 was the optimal cut‐off value for detecting a decreased masticatory function. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Transforming growth factor‐β‐regulated fractalkine as a marker of erosive bone invasion in oral squamous cell carcinoma

Greek DailyNews shared this article with you from Inoreader Transforming growth factor‐β‐regulated fractalkine as a marker of erosive bone invasion in oral squamous cell carcinoma Via European Journal of Oral Sciences Abstract Patients with oral squamous cell carcinoma (OSCC) bone invasion are surgically treated with bone resection, which results in severe physical and psychological damage. Here, we investigated the potential of fractalkine (CX3CL1), which is regulated by transforming growth factor (TGF‐β), as a novel biomarker for correct prediction and early detection of OSCC‐associated bone invasion. TGF‐β knockdown and treatment with a TGF‐β‐neutralizing antibody decreased the level of fractalkine in the culture media of HSC‐2 and YD10B OSCC cells. Treatment with a fractalkine‐neutralizing antibody reduced TGF‐β‐stimulated invasion by HSC‐2 and YD10B cells. Fractalkine treatment increased the viability, invasion, and uPA secretion of both OSCC cell lines. Furthermore, OSCC cell bone invasion was assessed following subcutaneous inoculation of wild‐type or TGF‐β knockdown OSCC cells in mouse calvaria. TGF‐β knockdown prevented erosive bone invasion, reduced the number o f osteoclasts at the tumor‐bone interface, and downregulated fractalkine expression in mouse tumor tissues. Our results indicate that the production of fractalkine is stimulated by TGF‐β and mediates TGF‐β‐induced cell invasion in several OSCC cell lines showing an erosive pattern of bone invasion. Fractalkine may be a useful predictive marker and therapeutic target for OSCC‐induced bone destruction. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Identification of Prostaglandin F2 Receptor Negative Regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development

Greek DailyNews shared this article with you from Inoreader Identification of Prostaglandin F2 Receptor Negative Regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development Via Head and neck cancers by Jorge Marquez, Jianping Dong, Chun Dong, Changsheng Tian, Ginette Serrero Antibody-drug conjugates (ADC) are effective antibody-based therapeutics for hematopoietic and lymphoid tumors. However, there is need to identify new targets for ADCs, particularly for solid tumors and cancers with unmet needs. From a hybridoma library developed against cancer cells, we selected the mouse monoclonal antibody 33B7, which was able to bind to, and internalize, cancer cell lines. This antibody was used for identification of the target by immunoprecipitation and mass spectrometric analysis, followed by target validation. After target validation, 33B7 binding and target positivity were tested by flow cytometry and western blot analysis in several cancer cell lines. The ability of 33B7 conjugated to saporin to inhibit in vitro proliferation of PTFRN positive cell lines was investigated, as well as the 33B7 ADC in vivo effect on tumor growth in athymic mice. All flow cytometry and in vitro internalization assays were analyzed for statistical significanc e using a Welsh's T-test. Animal studies were analyzed using Two-Way Analysis of Variance (ANOVA) utilizing post-hoc Bonferroni analysis, and/or Mixed Effects analysis. The 33B7 cell surface target was identified as Prostaglandin F2 Receptor Negative Regulator (PTGFRN), a transmembrane protein in the Tetraspanin family. This target was confirmed by showing that PTGFRN-expressing cells bound and internalized 33B7, compared to PTGFRN negative cells. Cells able to bind 33B7 were PTGFRN-positive by Western blot analysis. In vitro treatment PTGFRN-positive cancer cell lines with the 33B7-saporin ADC inhibited their proliferation in a dose-dependent fashion. 33B7 conjugated to saporin was also able to block tumor growth in vivo in mouse xenografts when compared to a control ADC. These findings show that screening antibody libraries for internalizing antibodies in cancer cell lines is a good approach to identify new cancer targets for ADC development. These results suggest PTGFRN is a possible therapeutic target via antibody-based approach for certain cancers. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Patient, Defect, and Surgical Factors Influencing Use of Ancillary Procedures after Facial Mohs Repairs

Greek DailyNews shared this article with you from Inoreader Patient, Defect, and Surgical Factors Influencing Use of Ancillary Procedures after Facial Mohs Repairs Via Facial Plastic Surgery Facial Plast Surg DOI: 10.1055/s-0040-1721100 This article determines if patient, defect, and repair factors can be used to predict the use of additional treatments to achieve optimal aesthetic results after repair of facial Mohs defects. An electronic chart review of patients undergoing Mohs excision and reconstruction of facial neoplasms from November 2005 to April 2017 was performed, reviewing patient demographics and history, tumor size, defect size and location, method and service of reconstruction, time between resection and repair, complications, and subsequent treatments. A total of 1,500 cases with basal cell and squamous cell carcinoma were analyzed. The average defect size was 3.09 ± 8.06 cm2; 81.9% of def ects were less than 4 cm2 in size. Advancement flaps were used to repair 44.3% of defects. Complications and undesired sequelae (CUS) were noted in 15.9% of cases; scar hypertrophy or keloid (10.8%) was most common. Postoperative ancillary procedures were performed in less than one-quarter (23.4%) of patients to enhance the postrepair appearance; the most common procedures were intralesional corticosteroid injections and pulse dye laser treatments. CUS were more likely in females (19.6%), defects on the lips (28.7%) and on the nose (27.3%) (p < 0.001 for each). Females (22.7% vs. 12.7%), lip repairs (40.2% vs. 18.3%), transposition flaps (39.2% vs. 14.8%), and repairs performed by a dermatologist (17.9% vs. 11.2%) (p < 0.001 for each) were more likely to be treated with postoperative corticosteroid injections. Females (14.5% vs. 7.4%), patients under the age of 60 years (13.9% vs. 8.8%), and patients whose repair was performed by a dermatologist (11.9% vs. 2.9%) (p� �< 0.001 for each) were more likely to receive postoperative pulsed dye laser treatments. CUS and ancillary procedures after repair of facial Mohs defects are uncommon. Awareness of individual risk factors and defect characteristics allows the surgeon to choose the most appropriate repair technique while anticipating the potential need for ancillary procedures. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The FACE-Q Rhinoplasty Module

Greek DailyNews shared this article with you from Inoreader Dutch Translation and Validation of the FACE-Q Rhinoplasty Module Via Facial Plastic Surgery Facial Plast Surg DOI: 10.1055/s-0040-1721099 FACE-Q was developed by Klassen et al in 2010 as a validated psychometric evaluation instrument for patients undergoing aesthetic surgery. The aim of this study was to translate, adapt, and validate the FACE-Q rhinoplasty module into a Dutch version of the FACE-Q questionnaire conceptually equivalent to the original English version. "Satisfaction with nose" and "satisfaction with nostrils" questionnaires were used and translated from English into Dutch. The translation process and cross-cultural adaptation were conducted in accordance to the International Society for Pharmacoeconomics and Outcomes Research and World Health Organization guidelines. Psychometric validation was performed prospectively on a patient cohort of 30 patients. Each step in the translation process allowed us to make changes to achieve a conceptual translation equivalent to the original version. Psychometric validation revealed highly significant values for internal consistency, test–retest reliability, and responsiveness. The use of international translation guidelines, with a strict translation–back-translation process, led to a Dutch version of the FACE-Q rhinoplasty module. Statistical validation proved the conceptual correspondence with the original English version. The FACE-Q rhinoplasty module is an adequate instrument for determining successful aesthetic surgery based on patient satisfaction. This tool measures twofold: the degree of success with respect to the patient as well as being an assessment tool for the surgeon. We hope this will provide an additional tool to the clinician evaluating the Dutch-speaking rhinoplasty patient. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Biomechanical Nasal Anatomy Applied to Open Preservation Rhinoplasty

Greek DailyNews shared this article with you from Inoreader Biomechanical Nasal Anatomy Applied to Open Preservation Rhinoplasty Via Facial Plastic Surgery Facial Plast Surg DOI: 10.1055/s-0040-1715622 Preservation rhinoplasty is a new way to reshape the nose by preserving the dorsum, nasal ligaments, soft tissue envelope, and muscles. This new concept provides the opportunity to achieve a more natural aesthetic and functional result. To achieve a good aesthetic and functional outcome while maintaining surgical safety, knowledge of the relevant anatomy is key. This is especially true for the preservation rhinoplasty technique, where a firm grasp of the anatomy of the nasal soft tissue and bony–cartilaginous framework is critical. The preservation technique is made more accessible by the open approach, which provides an opportunity for the deformity to be clearly visualized f rom the tip of the nose and the dorsum. Furthermore, tip plasty is easier to perform under direct vision, which is an advantage of the open approach. The goal of this article is therefore to make clear all the important anatomical structures and their relevance to the surgical steps taken when performing the open preservation rhinoplasty technique. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.