Effects of salicylate derivatives on localization of p.H723R allele product of SLC26A4

xlomafota13 shared this article with you from Inoreader Effects of salicylate derivatives on localization of p.H723R allele product of <em>SLC26A4</em> Via Auris Nasus Larynx Publication date: Available online 16 March 2022 Source: Auris Nasus Larynx Author(s): Michio Murakoshi, Yuhi Koike, Shin Koyama, Shinichi Usami, Kazusaku Kamiya, Katsuhisa Ikeda, Yoichi Haga, Kohei Tsumoto, Hiroyuki Nakamura, Noriyasu Hirasawa, Kenji Ishihara, Hiroshi Wada View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Voice Symptoms and Wellbeing in School Teachers in England

xlomafota13 shared this article with you from Inoreader Voice Symptoms and Wellbeing in School Teachers in England Via Journal of Voice Negative psychological factors such as depression and other common mental disorders have been found to be associated with voice problems in teachers. However, there is little research with teachers that investigates the relationship between positive psychological factors such as wellbeing and voice problems. Although negative and positive mental states are on a continuum of psychological health, research suggests negative and positive effects are not necessarily inversely correlated and therefore need to be investigated separately. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Active Surveillance Versus Thyroid Surgery for Differentiated Thyroid Cancer: A Systematic Review

xlomafota13 shared this article with you from Inoreader Active Surveillance Versus Thyroid Surgery for Differentiated Thyroid Cancer: A Systematic Review Via liebertpub1 Thyroid, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Acute anterior thigh compartment syndrome in Premiership rugby

xlomafota13 shared this article with you from Inoreader Acute anterior thigh compartment syndrome in Premiership rugby Via swallowing exercises BMJ Case Rep. 2022 Mar 15;15(3):e247307. doi: 10.1136/bcr-2021-247307. ABSTRACT A case study of acute compartment syndrome in the anterior lateral thigh of a professional Rugby Union Flanker with no history of trauma is presented. The report covers all details from initial occurrence; medical history; investigations and surgical treatment; manual stimulus and rehabilitation; return to play; challenges and considerations-resulting in a positive outcome. Resultant observations/recomm endations are that investigations should be swift and carefully considered to facilitate surgical intervention via decompressive fasciotomy as required. PMID:35292543 | DOI:10.1136/bcr-2021-247307 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Stability of extemporaneously prepared sitagliptin phosphate solution

xlomafota13 shared this article with you from Inoreader Stability of extemporaneously prepared sitagliptin phosphate solution Via swallowing exercises PLoS One. 2022 Mar 16;17(3):e0262068. doi: 10.1371/journal.pone.0262068. eCollection 2022. ABSTRACT Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used orally in conjunction with diet and exercise to control sugar levels in type 2 Diabetes Mellitus patients. This study aimed to extemporaneously prepare SiP solution (1% w/v) using pure Sitagliptin phosphate (SiP) powder and assess its stability according to pharmaceutical regulatory guidelines. Four SiP solutions, coded T1, T2, T3, and T4, were extemporaneously prepared using pure SiP powder as a source of API. The most suitable one, in terms of general organoleptic properties, was selected for further investigations, including stability studies. For this last purpose, samples of the T4 solution were kept under two storage conditions, room temperature (25˚C and 60% Relative Humidity) and accelerated stability conditions (40˚C and 75% Relative Humidity). Assay, pH, organoleptic properties, related substances, and microbial contamination were evaluated for 4 consecutive weeks. A High-Performance Liquid Chromatography (HPLC) analytical method was developed and validated to be used for the analysis and quantification of SiP in selected solution formulation. The adopted formula had a pH on the average of 3 to 4. During the stability tests, all pH values remained constant. Furthermore, after 4 weeks of storage under both conditions, the SiP concentration was close to 100%. A stable SiP extempora neous solution was successfully prepared using pure SiP powder. Patients with swallowing problems who use feeding tubes and are unable to take oral solid dosage forms may benefit from this research. Community pharmacists can prepare the solution using sitagliptin powder as the source of the active ingredient. PMID:35294449 | DOI:10.1371/journal.pone.0262068 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Introducing Zirconium Organic Gels for Efficient Radioiodine Gas Removal

xlomafota13 shared this article with you from Inoreader Introducing Zirconium Organic Gels for Efficient Radioiodine Gas Removal Via radioactive iodine Inorg Chem. 2022 Mar 15. doi: 10.1021/acs.inorgchem.1c03159. Online ahead of print. ABSTRACT Iodine radioisotope, as one of the most important fission products of uranium, may cause severe damage to human health when it is accidentally discharged into the environment. Hence, efficient removal of radioactive iodine is one of the most critical issues for both used nuclear fuel (UNF) reprocessing and environmental remediation. In this work, three metal-organic gels (MOGs) were introdu ced for iodine removal. The presented zirconium-based MOGs, namely, CWNU, CWNU-NH2, and CWNU-2NH2, were prepared via moderate solvothermal reactions. These MOGs all exhibit excellent chemical stability and reusability, marked iodine sorption capability, and favorable machinability, which can even rival commercial ones. The sorption capacities are determined to be 3.36, 4.10, and 4.20 g/g, respectively. The increased amount of amino group is considered to be responsible for the elevated iodine sorption capacity and kinetics, as confirmed by combined sorption studies and XPS analysis. The presented work sheds light on the utilization of MOGs for radioiodine capture. PMID:3528 9614 | DOI:10.1021/acs.inorgchem.1c03159 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clinical Factors Predictive of Lymph Node Metastasis in Thyroid Cancer Patients: A Multivariate Analysis

xlomafota13 shared this article with you from Inoreader Clinical Factors Predictive of Lymph Node Metastasis in Thyroid Cancer Patients: A Multivariate Analysis Via radioactive iodine J Am Coll Surg. 2022 Apr 1;234(4):691-700. doi: 10.1097/XCS.0000000000000107. ABSTRACT BACKGROUND: Early-stage thyroid cancers have excellent survival. However, lymph node metastases (LNM) confer a worse prognosis and are not always known preoperatively. Therefore, investigation on the clinical and histological factors predictive of LNM in thyroid cancers was conducted to tailor the extent of surgery and radioactive iodine therapy. STUDY DESIGN: Multivariate logistic regressi ons were performed based on retrospective data from thyroid cancer patients seen between 2013 and 2020 at a single institution. RESULTS: Among 913 patients, mean age was 49.4 years, 76.5% were female, 58.3% were White, 21.2% were Black, and 27.9% had LNM. In the multivariate analyses in which the outcome was LNM, White (odds ratio [OR] 1.74, 95% CI 0.98 to 3.15, p = 0.064) and Hispanic patients (OR 2.36, 95% CI 0.97 to 5.77, p = 0.059) trended toward higher risk of LNM compared to Black patients, whereas age (OR 0.98, 95% CI 0.97 to 1.00, p = 0.008) showed protective effect. Tumor size (OR 1.04, 95% CI 1.01 to 1.07, p = 0.007), extrathyroidal extension (OR 2.46, 95% CI 1.53 to 3.97, p < 0.001), lymphovascular invasion (OR 6.30, 95% CI 3.68 to 11.14, p < 0.001), and multifocality (OR 1.47, 95% CI 1.01 to 2.12, p = 0.042) were associated with higher risk of LNM. In another model with outcome as >5 LNM, tumor size (OR 1.07, 95% CI 1.03 to 1.11, p = 0.001), age (OR 0.95, 95% CI 0.93 to 0.97, p < 0.001), extrathyroidal extension (OR 3.20, 95% CI 1.83 to 5.61, p < 0.001), and lymphovascular invasion (OR 6.82, 95% CI 3.87 to 12.17, p < 0.001) remained significant predictors. CONCLUSION: Our analyses demonstrated and confirmed that age, tumor size, extrathyroidal extension, and lymphovascular invasion are independent predictors of significant LNM, thereby conferring higher risk of recurrence. Risk of LNM based on these patient characteristics should be considered when planning an operative approach. PMID:35290290 | DOI:10.1097/XCS.0000000000000107 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Radioguided surgery with iodine-125 seeds in breast cancer patients treated with neoadjuvant chemotherapy

xlomafota13 shared this article with you from Inoreader Radioguided surgery with iodine-125 seeds in breast cancer patients treated with neoadjuvant chemotherapy Via radioactive iodine Rev Esp Med Nucl Imagen Mol (Engl Ed). 2022 Mar-Apr;41(2):71-77. doi: 10.1016/j.remnie.2021.04.017. Epub 2021 May 25. ABSTRACT OBJECTIVE: To evaluate the use of radioactive iodine-125 seed (RIS) in breast and/or axillary surgery, in patients with breast cancer treated with neoadjuvant chemotherapy (NAC). MATERIAL AND METHODS: Prospective study between January 2016 and June 2020. 80 women T1-3,N0-2,M0: 30 RIS marking the breast tumor, 36 both the tumor and the biopsied positiv e axillary node, and 14 only the axilla. Age: 54.7 ± 11.4 years. Tumor size: 34.1 ± 14.6 mm. Histological type: invasive ductal carcinoma 90.0%. Molecular subtypes: luminal-A 23.8%, luminal-B/HER2- 33.7%, luminal-B/HER2+ 18.8%, HER2+ 7.5%, basal-like 16,2%. RESULTS: Of the 66 patients with RIS marking of the tumor (51 pre-NAC, 15 post-NAC), 92.1% had tumor-free surgical margins, with a specimen volume of 126.7 ± 111.2 cm3. Of the 5 s local excisions, in 3 the resection margin was involved (1 mastectomy). Of the 50 patients N1 with RIS marking (MLN), 44 pre-NAC and 6 post-NAC, MLN was identified in 97.2%: negative 23, positive 26. In 45/50 patients, sentinel node biopsy (SNB) was performed and it was identified in 93.3%: negative 26, positive 16. In 1 case RIS was not placed correctly and SNB was not identified due to non-migration. In 61.9% of the patients, MLN was among the SNB identified in the surgery. In 5 patients with mismatched SNB and MLN, the pathologica l result of the SNB was negative and the MLN was positive. Axillary lymph node dissection was performed in 53.8% of the patients. CONCLUSION: RIS allow to perform breast-conserving surgery and improve detection of residual axillary disease in patients treated with NAC. PMID:35292141 | DOI:10.1016/j.remnie.2021.04.017 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease

xlomafota13 shared this article with you from Inoreader Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease Via cortical auditory PLoS One. 2022 Feb 24;17(2):e0264333. doi: 10.1371/journal.pone.0264333. eCollection 2022. ABSTRACT Deep brain stimulation (DBS) has proven its clinical efficacy in Parkinson's disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencep halography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS. PMID:35202426 | PMC:PMC8870490 | DOI:10.1371/journal.pone.0264333 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pediatric morphometric study to guide the optimized implantation of the Osia® 2 implant system

xlomafota13 shared this article with you from Inoreader Pediatric morphometric study to guide the optimized implantation of the Osia<sup>®</sup> 2 implant system Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Mar 16. doi: 10.1007/s00405-022-07338-2. Online ahead of print. ABSTRACT PURPOSE: Continuous technological advances result in the availability of new bone conduction hearing implants, of which their suitability for pediatric patients is of major concern. The CochlearTMOsia® 2 is a new active osseointegrated steady-state implant system that uses digital piezoelectric stimulation to treat hearing loss. The implant in the United States was approved for patients aged 12 years and above, whereas the CE mark is independent of age, the only requirement is body weight of at least 7 kg. Therefore, further clinical studies are required to assess device characteristics in younger patients. The aim of our study was to perform a morphometric study among 5-12-year-old children, and to develop a surgical protocol for Osia 2 system implantation based on these findings. METHODS: We examined r etrospectively cranial CT scans of 5-12-year-old patients from our clinical database. We measured the bone and soft-tissue thickness in the region of interest, and the position of the sigmoid sinus. 3D printed temporal bones were also used for planning. RESULTS: Soft-tissue thickness varied between 3.2 ± 0.5 mm and 3.6 ± 0.6 mm and bone thickness varied between 3.5 ± 1.1 mm and 4.7 ± 0.3 mm. The sigmoid sinus was located 1.3 ± 0.2 cm posterior to the ear canal, and the anterior distance was 4.8 ± 0.9 to 7.1 ± 1.1 mm. CONCLUSIONS: Our morphometric studies showed that patients aged 5-12 have different anatomical dimensions compared to adults, but that implantation of the Osia 2 system is feasible in these patients using an altered implant positioning recommended by our data. The Cochlear™ Osia® 2 is, therefore, an option for hearing rehabilitation in younger pediatrics. PMID:35292851 | DOI:10.1007/s00405-022-07338-2 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The feasibility of SHIMP for judging subjective vertigo and recovery in patients with vestibular neuritis

xlomafota13 shared this article with you from Inoreader The feasibility of SHIMP for judging subjective vertigo and recovery in patients with vestibular neuritis Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Mar 16. doi: 10.1007/s00405-022-07299-6. Online ahead of print. ABSTRACT PURPOSE: We aimed to study the results of the head impulse paradigm (HIMP) and the suppression head impulse paradigm (SHIMP) in patients with acute vestibular neuritis (AVN) to compare dizziness handicap inventory (DHI) scores before and after treatment. We also wanted to investigate the correlation between the HIMP, SHIMP and DHI score and to analyze the factors that affect the recovery with AVN in the short term. METHODS: The HIMP, SHIMP, and DHI score were assessed in 20 patients with AVN before (T0) and after treatment (T1). We collected the following indicators: T0, T1-HIMP VOR gain; T0, T1-SHIMP VOR gain; the percentage of the anti-compensatory saccades of T0-SHIMP and T1-SHIMP on the affected side; T0-DHI score, T1-DHI score; and efficacy index (EI). The correlation between HIMP and SHIMP parameters with the DHI score and EI was analyzed, and the factors that affect the recovery of patients with AVN were assessed. RESULTS: T0-SHIMP anti-compensatory saccades (%),T1-SHIMP VOR gain, and T1-SHIMP anti-compensatory saccades (%) were significantly correlated with the corresponding DHI score and EI (P < 0.05). T0, T1-HIMP VOR gain and T0-SHIMP VOR gain had no correlation with the corresponding DHI score and EI (P > 0.05). T0-SHIMP anti-compensatory saccades (%) significantly affect EI (P < 0.05). CONCLUSION: Both HIMP and SHIMP can assess the current vestibular function and recovery of AVN patients, but SHIMP can more accurately reflect the degree of subjective vertigo. At the same time, T0-SHIMP anti-compensatory saccades (%) can be used as a good index to evaluate the short-term recover y of AVN patients. PMID:35296947 | DOI:10.1007/s00405-022-07299-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.