Head and Neck Diseases by Alexandros G.Sfakianakis: 02/19/17

Κυριακή 19 Φεβρουαρίου 2017

Nasal cavity myiasis presenting with preseptal cellulitis

Volume 2, Issue 1, December 2017, Page 26-28
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De-escalation of radiotherapy for the treatment of HPV-associated head and neck cancer: A case report and a word of caution

Volume 2, Issue 1, December 2017, Page 29-33
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Multiple cerebral venous thrombosis after endoscopic stapedotomy: A potential role of endoscope-produced heat

Volume 2, Issue 1, December 2017, Page 21-25
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Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) induced by golimumab

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Pemphigus and nonassociation with antecedent neurological diseases: a case–control inpatient cohort

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Health Issues of Primary School Students Residing in Proximity of an Oil Terminal with Environmental Exposure to Volatile Organic Compounds.

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Health Issues of Primary School Students Residing in Proximity of an Oil Terminal with Environmental Exposure to Volatile Organic Compounds.

Biomed Res Int. 2016;2016:4574138

Authors: Cipolla M, Bruzzone M, Stagnaro E, Ceppi M, Izzotti A, Culotta C, Piccardo MT

Abstract
Residential proximity to industrial sites has been associated with adverse effects on human health. Children are more susceptible to airborne environmental exposure because their immune and respiratory systems are still developing. This study aimed to investigate whether living close to an oil terminal in Genoa where there is higher VOCs exposure is associated with an increased rate of school absenteeism because of disease in primary school children. Five schools were chosen for the recruitment of children and students residing in the industrial site (A) were compared to those living in residential sites (B). Sixty-six of the 407 students involved in the project were also selected for VOC monitoring. Source apportionment was carried out by comparing profiles of VOCs; principal component analysis was performed to study the correlation between profiles, and Kriging interpolation model was used to extend profiles to all participants. The concentration means of total VOCs were significantly higher in the industrial areas compared to controls. Adjusting for potential confounders, children who lived in area A had a significantly higher risk of being absent from school due to sore throat, cough, and cold compared to controls. o-Xylene, which is dispersed during the industrial activity, showed clear evidence of a significant association with respiratory symptoms.

PMID: 27446951 [PubMed - indexed for MEDLINE]

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Detecting RNA modifications in the epitranscriptome: predict and validate

Although it has been known for decades that RNA is subjected to numerous covalent modifications, there has been a recent surge in interest driven by sequencing-based transcriptome-wide detection methods and the realization that RNA modifications have important roles in diverse biological processes. This Review describes the range of detection strategies for RNA modifications, their particular strengths and limitations, and how responsible and complementary application of these techniques will be required to ensure the quality and interpretability of the rapidly accumulating data sets.

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Craniosynostosis, delayed closure of the fontanelle, anal, genitourinary, and skin abnormalities (CDAGS syndrome): first report in a Mexican patient and review of the literature

Abstract

Introduction

Craniosynostosis and clavicular hypoplasia, delayed closure of the fontanelle, cranial defects, anal and genitourinary abnormalities, and skin (CDAGS), is an infrequent autosomal recessive entity with only 10 cases reported; no associated gene has been identified so far.

Case Report

The proband is a 2-year-old Mexican female with brachycephaly, cleft palate, anal malformation with rectovestibular fistula, and clinodactyly of the third toe overlapping the second. At 4 months of age, she developed a disseminated dermatosis with erythematous scaly nummular plaques, elevated keratotic sharp borders with thin to broad flaking, hematic crusts, and keratotic surface in others. The lesions were slightly pruritic and began at the lower limbs with posterior dissemination to the upper limbs, head, and trunk; palms and soles were unaffected. A skin biopsy showed hyperkeratosis, parakeratosis, acanthosis, and perivascular inflammatory infiltration in the upper reticular dermis among other alterations. She also presented mild bilateral neurosensory hypoacusia and enamel dysplasia. Her karyotype was normal. Treatment with topical hydrating creams partially improved the skin lesions at their center, while the sharply keratotic borders remained, giving a clinical resemblance to porokeratosis.

Discussion

The patient suffers from CDAGS syndrome but has normal development, and feet abnormality was described in only one other patient. The treatment with topical hydrating creams improved the skin lesions at their center, while porokeratotic characteristics persisted. CDAGS remains a diagnostic challenge; a comparison with previously reported cases is discussed. The timely detection of the syndrome will allow early treatment that may improve the condition of the patients.

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Evidence for the association of Hashimoto's thyroiditis with psoriasis: a cross-sectional retrospective study

Abstract

Background

Current information indicates that psoriasis is a metabolic disorder with systemic manifestations. Reports have revealed an association between psoriasis and several chronic autoimmune disorders. For one of these disorders, Hashimoto's thyroiditis (HT), there are scarce, and relatively unconfirmed, reports of an association with psoriasis. We sought to determine if such an association is detectable in a large medical record data repository.

Methods

We searched one institution's electronic medical record data repository from January 2010 to December 2013. Patients were identified by ICD-9 codes (psoriasis: 696.0; 696.1, HT: 245.2). Only data from patients with laboratory-confirmed HT (anti-thyroid peroxidase [anti-TPO] antibodies; thyroglobulin antibodies; serum thyroid-stimulating hormone; and free T3) were eligible for inclusion. Logistic regression analysis was used to obtain an odds ratio (OR) to establish an association between psoriasis and HT. Stratified analyses were performed to test for confounding variable and effect modification.

Results

Medical records for 856,615 individuals with documented encounters between January 1, 2010, and December 31, 2013, were detected. A total of 9654 had a diagnosis of psoriasis, and 1745 had a diagnosis of HT. Of these, 41 subjects were diagnosed with both conditions. A significant association existed for psoriasis and HT, even after adjusting for confounding variables that included gender, age, psoriatic arthropathy, and the use of systemic anti-psoriatic agents (OR = 2.49; 95% CI 1.79–3.48; P < 0.0001).

Conclusions

This association has broad clinical impact and deserves further attention with regard to patient care, clinical research, and developmental therapeutics.

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A Rare Cause of Childhood Cerebellitis-Influenza Infection: A Case Report and Systematic Review of Literature

Acute cerebellitis is a benign neurologic condition generally caused by viral or bacterial infections. Influenza associated cerebellitis is extremely rare; a 6-year-old boy with acute cerebellitis, who presented with fever, vomiting, weakness, febrile seizure, and acute cerebellar features, is discussed in this article.

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Airborne bacterial contamination during orthopedic surgery: A randomized controlled pilot trial

Several factors such as lack of unidirectional, turbulent free laminar airflow, duration of surgery, patient warming system, or the number of health professionals in the OR have been shown or suspected to increase the number of airborne bacteria. The objective of this study was to perform a multivariate analysis of bacterial counts in the OR in patients during minor orthopedic surgery.

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Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial

To compare the incidence of postoperative cognitive dysfunction (POCD) in elderly surgical patients (>60years) receiving different anesthetics (propofol, sevoflurane, or isoflurane) and to identify potential biomarkers of POCD in this patient population.

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What's in a dose? Advantages and disadvantages of reducing local anesthetic requirements in children

Prior to the widespread use of ultrasound guidance in regional anesthesia, higher volumes of local anesthetic were often required to achieve reliable blockade with landmark and neurostimulation techniques. The ability to clearly visualize neural structures with ultrasound guidance has resulted in more precise delivery of local anesthetic around the target nerve or plexus, which should theoretically reduce the risk of complications such as local anesthetic systemic toxicity (LAST) as well as tissue toxicity to nerves and surrounding muscle.

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The impact of the fabrication method on the three-dimensional accuracy of an implant surgery template

The use of a surgical template is a well-established method in advanced implantology. In addition to conventional fabrication, computer-aided design and computer-aided manufacturing (CAD/CAM) work-flow provides an opportunity to engineer implant drilling templates via a three-dimensional printer. In order to transfer the virtual planning to the oral situation, a highly accurate surgical guide is needed. The aim of this study was to evaluate the impact of the fabrication method on the three-dimensional accuracy.

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Proposal for a new risk classification system for nasopharyngeal carcinoma patients with post-radiation nasopharyngeal necrosis

Radiotherapy (RT) is the mainstay treatment for nasopharyngeal carcinoma (NPC). Recent developments in RT technique have resulted in improved survival rates even among locoregionally advanced NPC patients, with a 3-year overall survival (OS) rate from 71.0% to 94.3% [1,2]. Nevertheless, complications of the irradiation fields are inevitable and the quality of life among NPC survivors is often compromised [3–6].

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Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas

Buccal squamous cell carcinoma (SCC) is rare in Western countries, representing approximately 10% of all oral cavity SCC [1]. However, its prevalence has been reported to be similar to that of tongue SCC in areas where betel quid chewing is endemic [2]. This phenomenon has been attributed to the well-known carcinogenic effect of betel quid chewing in the long-term [2]. The prevalence rates of betel quid chewing in Taiwanese males and females are 20.9% and 1.2%, respectively. In Taiwan, the significant sex-related differences in the frequency of tobacco and betel quid chewing may explain the higher incidence of oral cavity SCC in males (20.81 cases per 1 million persons) than in females (2.40 cases per 1 million persons).

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Effect of hyaluronic acid on the regulation of inflammatory mediators in osteoarthritis of the temporomandibular joint: a systematic review

Osteoarthritis is one of the most frequent pathologies affecting the temporomandibular joint (TMJ). There is evidence that the use of intra-articular hyaluronic acid (HA) for the treatment of this disorder achieves positive effects through a reduction in inflammatory mediators. A systematic review of the available evidence regarding the regulation of inflammatory mediators when applying HA in osteoarthritis of the TMJ in humans was performed. The Web of Science, Embase, ScienceDirect, MEDLINE, Scopus, EBSCOhost, and LILACS databases, SciELO library, and search engine Trip Database were searched systematically.

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The Inferior Turbinate in Rhinoplasty

There is controversy regarding optimum treatment of the hypertrophied inferior turbinate. Patients undergoing rhinoplasty will likely need treatment of bony hypertrophy as well as possibly soft tissue hypertrophy. Although inferior turbinate hypertrophy is a heterogeneous entity, future studies should standardize outcome measures and compare treatment methods with rigorous clinical trials.

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Osteotomies Demystified

Osteotomies are critical techniques in rhinoplasty. There are a variety of approaches, trajectories, and tools used with no widely standardized classification or nomenclature. Percutaneous osteotomies are gaining in popularity, and picture framing the nasomaxillary bone is crucial for predictable fracture and reproducible results. This is best accomplished with medial, lateral, and transverse osteotomies. Intermediate osteotomies are used less frequently, but provide more mobility. With a detailed understanding of anatomy and a thorough approach to nasal osteotomies, the contour and function of the bony vault can be reshaped with a successful outcome for both the surgeon and patient.

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Advances in Technology for Functional Rhinoplasty

Advances in computer modeling and simulation technologies have the potential to provide facial plastic surgeons with information and tools that can aid in patient-specific surgical planning for rhinoplasty. Finite element modeling and computational fluid dynamics are modeling technologies that have been applied to the nose to study structural biomechanics and nasal airflow. Combining these technologies with patient-specific imaging data and symptom measures has the potential to alter the future landscape of nasal surgery.

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Management of Pediatric Nasal Surgery (Rhinoplasty)

Nasal surgery in children, most often performed after trauma, can be performed safely in selected patients with articulate, deliberate, and conscientious operative plan. All nasal surgery in children seeks to avoid disruption of the growth centers, preserving and optimizing nasal growth while improving the form and function of the nose. A solid appreciation of long-term outcomes and effects on growth remain elusive.

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Revision Functional Surgery

Reduction rhinoplasty techniques include maneuvers that weaken the nasal osseocartilaginous framework. The structurally compromised anatomy remaining after reductive surgery may be left with inadequate strength to withstand postoperative contractile forces. Significant aesthetic and functional deformities requiring revision rhinoplasty may develop. This article reviews common causes of nasal obstruction after primary rhinoplasty. The discussion of etiology is based on both the anatomic description of nasal subsites (middle vault and lateral walls) as well as an explanation of why certain techniques lead to functional problems in these areas. Revision rhinoplasty techniques for correcting these problems are discussed in detail.

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Functional Rhinoplasty

Understanding nasal anatomy and physiology are the most important points for successful functional rhinoplasty. Anatomic structures playing major roles in nasal breathing functions include the septum, and internal and external nasal valves, so physical examination of these regions is essential. Planning for functional rhinoplasty involves the identification of the sites of nasal airway obstruction or old trauma, and addressing those regions during the operation with a number of different techniques that have been described.

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Septoplasty

Nasal septal deviation is a prevalent problem that can have significant quality of life ramifications. Septoplasty is commonly performed to provide qualitative and quantitative benefit to those who with nasal obstruction owing to septal deviation. Although a standard, basic technique is often adequate for individuals with mild to moderate mid to posterior septal deviation, unique challenges arise with caudal septal deviation. Herein, multiple strategies that attempt to address anterior septal deviation are discussed. Anterior septal reconstruction has been shown to be a safe and effective means by which to address severe caudal septal deviation and long-term reduction in preoperative symptoms.

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The External Nasal Valve

The external nasal valve is a complex entity comprised of multiple structures and tissue types. As such, there is no single operation that can address all problems of the external valve. This article reviews the relevant anatomy, pathologic conditions, and treatments for external nasal valve dysfunction, including a detailed review of the nasal muscles and their contribution to external nasal valve patency. Surgical and nonsurgical options for treatment and the evidence supporting the importance of proper external nasal valve function on quality-of-life measures are discussed.

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The Inferior Turbinate in Rhinoplasty

Osteotomies Demystified

Advances in Technology for Functional Rhinoplasty

Management of Pediatric Nasal Surgery (Rhinoplasty)

Revision Functional Surgery

Functional Rhinoplasty

Septoplasty

The External Nasal Valve

Myopericytoma in urinary bladder: a case report

Myopericytoma is reported to occur mainly in the skin and superficial soft tissue of the extremities. In contrast, occurrence in the urinary bladder is extremely rare.

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Myopericytoma in urinary bladder: a case report

Myopericytoma is reported to occur mainly in the skin and superficial soft tissue of the extremities. In contrast, occurrence in the urinary bladder is extremely rare.

http://ift.tt/2lk3uh0

Sleeve gastrectomy in the elderly: A case-control study with long-term follow-up of 3 years.

Sleeve gastrectomy in the elderly: A case-control study with long-term follow-up of 3 years.

Surg Obes Relat Dis. 2016 Dec 14;:

Authors: Navarrete A, Corcelles R, Del Gobbo GD, Perez S, Vidal J, Lacy A

Abstract
BACKGROUND: Advanced age is considered to be a relative contraindication to bariatric surgery because of increased perioperative risk and suboptimal excess weight loss.
OBJECTIVES: The aim of this study was to analyze the safety and effectiveness of the sleeve gastrectomy (SG) procedure in a cohort of elderly patients (aged≥60 yr) compared with younger patients (aged<60 yr).
SETTING: Hospital clinic, Barcelona, Spain.
METHODS: A retrospective analysis of all cases of SG in patients≥60 years old between January 2006 and December 2012 was performed.
RESULTS: The study included 206 patients, 103 in each group. The mean age was 63.3±2.8 years, and the body mass index was 45.8±22.8 kg/m(2). The overall complication rate within the elderly group was 9.7% versus 15.5% in the younger group (P = .2). After SG, there was no statistical difference in body mass index between the groups until 24 (33.4 versus 31.5 kg/m(2), P = .01) and 36 (34.6 versus 32.8 kg/m(2), P = .01) months of follow-up, favoring the younger cohort. Mean percent excess weight loss was similar between the groups during all periods of follow-up. The mean percent total weight loss change was statistically higher in the younger group at 3 (15.1% versus 17.1%, P = .03); 6 (25.2% versus 27.5%, P = .04); 12 (32.4% versus 35.2%, P = .03); 24 (26.7% versus 32.4%, P<.01); and 36 months (24.9% versus 29.1%, P<.01). Neither groups revealed a statistical difference in resolution of all co-morbidities, except for obstructive sleep apnea (P = .02) in the younger group.
CONCLUSIONS: SG is a safe and feasible procedure in the elderly with results comparable to those in the standard bariatric population.

PMID: 28214166 [PubMed - as supplied by publisher]

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Peripheral blood leukocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study.

Peripheral blood leukocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study.

Colorectal Dis. 2017 Feb 18;:

Authors: Alonso S, Mayol X, Nonell L, Salvans S, Pascual M, Pera M, Colorectal Cancer Research Group (Hospital del Mar Medical Research Institute)

Abstract
AIM: Anastomotic leak is associated with higher rates of recurrence after surgery for colorectal cancer. However, the mechanisms responsible are unknown. We hypothesized that the infection-induced inflammatory response may induce overexpression of tumour progression-related genes in immune cells. The aim was to investigate the effect of postoperative intra-abdominal infection on the gene expression patterns of peripheral blood leukocytes (PBL) after surgery for colorectal cancer.
METHODS: Prospective matched cohort study. Patients undergoing surgery for colorectal cancer were included. Patients who had anastomotic leak or intra-abdominal abscess were included in the infection group (n=23), and matched with patients without complications for the control group (n=23). PBL were isolated from postoperative blood samples. Total RNA was extracted and hybridized to the Affymetrix Human Gene 1.0 ST microarray.
RESULTS: Patients in the infection group displayed 162 genes upregulated and 146 genes downregulated respect to the control group. Upregulated genes included examples coding for secreted cytokines involved in tumour growth and invasion (S100P, HGF, MMP8 and 9, PDGFC, IL1R2). Infection also upregulated some proangiogenic genes (CEP55, TRPS1) while downregulated some inhibitors of angiogenesis (MME, ALOX15, CXCL10). Finally, some inhibitors (HP, ORM1, OLFM4, IRAK3) and activators (GNLY, PRF1, FGFBP2) of antitumour immunity were upregulated and downregulated, respectively, suggesting that the inflammatory environment caused by a postoperative infection favour tumour immune evasion mechanisms.
CONCLUSION: Analysis of PBL shows differential expression of certain tumour progression-related genes in colorectal cancer patients having postoperative intra-abdominal infection, which in turn may promote the growth of residual cancer cells to become recurrent tumours. This article is protected by copyright. All rights reserved.

PMID: 28214365 [PubMed - as supplied by publisher]

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Long-term outcomes of endolymphatic sac shunting with local steroids for Meniere's disease.

Long-term outcomes of endolymphatic sac shunting with local steroids for Meniere's disease.

Am J Otolaryngol. 2017 Jan 20;:

Authors: Wick CC, Manzoor NF, McKenna C, Semaan MT, Megerian CA

Abstract
OBJECTIVES: To evaluate the long-term efficacy of endolymphatic sac shunt techniques with and without local steroid administration.
STUDY DESIGN: Retrospective case series and patient survey.
SETTING: Tertiary university hospital.
PATIENTS: Meniere's disease (MD) patients that failed medical therapy and subsequently underwent an endolymphatic sac shunt procedure. All patients had definitive or probable MD and at least 18-months of follow-up.
INTERVENTIONS: Three variations on endolymphatic sac decompression with shunt placement were performed: Group A received no local steroids, Group B received intratympanic dexamethasone prior to incision, and Group C received dexamethasone via both intratympanic injection and direct endolymphatic sac instillation.
MAIN OUTCOME MEASURE(S): Vertigo control, hearing results, and survey responses.
RESULTS: Between 2002 and 2013, 124 patients with MD underwent endolymphatic sac decompression with shunt placement. 53 patients met inclusion criteria. Groups A, B, and C had 6 patients, 20 patients, and 27 patients, respectively. Mean follow-up was 56months. Vertigo control improved in 66%, 83%, and 93% of Groups A, B, and C. Functional level improved for Group B (-2.0) and Group C (-2.2) but was unchanged in Group A. Pure-tone average and speech discrimination scores changed by +22dB and -30%, +6dB and -13%, and +6dB and -5% in Groups A, B, and C. The long-term hearing results were significantly better with steroids (Groups B and C) according to the AAO-HNS 1995 criteria but did not meet significance on non-parametric testing.
CONCLUSIONS: Endolymphatic sac shunt procedures may benefit from steroid instillation at the time of shunt placement.

PMID: 28214024 [PubMed - as supplied by publisher]

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POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells.

POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells.

Int J Cancer. 2017 Feb 18;:

Authors: Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X

Abstract
The identification and understanding of the molecular network of cancer stem cells (CSCs) have had a profound impact on our view of carcinogenesis and treatment strategy. Unfortunately, a major problem is that serial passages of CSCs from clinical solid tumor specimens currently are not available in any lab, and thus, reported data are difficult to confirm and intensively interrogated. Here, we have generated two tumor tissue-derived breast CSC (BCSC) lines that showed prolonged maintenance over 20 serial passages in vitro, while retaining their tumor-initiating biological properties. We then deciphered the intrinsic mechanism using analyses of mRNA expression array profiles. It has been determined that pro-opiomelanocortin (POMC) is closely related with protein phosphorylation mediated by G protein-coupled estrogen receptor (GPER) in BCSC. Following, knockdown of POMC inhibits properties of mammosphere formation, CD44(+) CD24(-) population, CD44 expression, and clonogenicity ability in BCSC. We found that inhibition of POMC attenuates phosphorylation of AKT2 and GSK3β in BCSC. Further in vivo investigations demonstrated that POMC interference regulates proliferation of BCSC-bearing tumors. Combination of the clinical results that POMC positive expression is frequently up-regulated in human breast cancer and POMC positivity correlated with a poor prognosis, POMC is a potential therapeutic target for BCSC. In conclusion, we have successfully established two long-term-cultured BCSC from clinical specimens. We further indicated that POMC acts as a potential therapeutic target and prognostic marker for future treatment of BCSC. This article is protected by copyright. All rights reserved.

PMID: 28214331 [PubMed - as supplied by publisher]

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Prognosis of residual axillary disease after neoadjuvant chemotherapy in clinically node-positive breast cancer patients: isolated tumor cells and micrometastases carry a better prognosis than macrometastases.

Prognosis of residual axillary disease after neoadjuvant chemotherapy in clinically node-positive breast cancer patients: isolated tumor cells and micrometastases carry a better prognosis than macrometastases.

Breast Cancer Res Treat. 2017 Feb 17;:

Authors: van Nijnatten TJ, Simons JM, Moossdorff M, de Munck L, Lobbes MB, van der Pol CC, Koppert LB, Luiten EJ, Smidt ML

Abstract
PURPOSE: The aim of this study was to compare disease-free survival (DFS) and overall survival (OS) between clinically node-positive breast cancer patients, treated with neoadjuvant chemotherapy (NAC), with axillary pathologic complete response (ypN0), residual axillary isolated tumor cells or micrometastases (ypNitc/mi), and residual axillary macrometastases (ypN1-3).
METHODS: All patients diagnosed with clinically node-positive primary invasive breast cancer treated with NAC and subsequent axillary lymph node dissection between 2005 and 2008 were retrospectively analyzed. Data were obtained from the Netherlands Cancer Registry. Patients were stratified by final pathological axillary status: ypN0, ypNitc/mi, or ypN1-3. The main outcome measures DFS and OS were analyzed using Kaplan-Meier survival analysis. Uni- and multivariable cox regression analyses were used to determine independent predictors for DFS and OS.
RESULTS: A total of 1347 patients were included. Pathologic nodal status was ypN0 in 22.2%, ypNitc/mi in 3.8%, and ypN1-3 in 74.0% of patients. Overall, 5-year DFS was 57.8% and mean OS was 7.4 years. DFS and OS were comparable between ypN0 and ypNitc/mi (HR 1.38 (0.40-4.79, p = 0.613) and HR 0.92 (0.27-3.09, p = 0.889), respectively), but significantly different between ypN0 and ypN1-3 (HR 1.78 (1.06-3.00, p = 0.031) and HR 1.70 (1.07-2.71, p = 0.026), respectively).
CONCLUSIONS: Clinically node-positive patients, treated with NAC, with axillary nodal status ypN0 or ypNitc/mi carry similar prognosis regarding DFS and OS. Axillary nodal status ypN1-3 is associated with a less favorable prognosis. Future studies should consider ypN0 and ypNitc/mi as one entity.

PMID: 28213782 [PubMed - as supplied by publisher]

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Exome analysis of Smith-Magenis-like syndrome cohort identifies de novo likely pathogenic variants.

Exome analysis of Smith-Magenis-like syndrome cohort identifies de novo likely pathogenic variants.

Hum Genet. 2017 Feb 17;:

Authors: Berger SI, Ciccone C, Simon KL, Malicdan MC, Vilboux T, Billington C, Fischer R, Introne WJ, Gropman A, Blancato JK, Mullikin JC, NISC Comparative Sequencing Program, Gahl WA, Huizing M, Smith AC

Abstract
Smith-Magenis syndrome (SMS), a neurodevelopmental disorder characterized by dysmorphic features, intellectual disability (ID), and sleep disturbances, results from a 17p11.2 microdeletion or a mutation in the RAI1 gene. We performed exome sequencing on 6 patients with SMS-like phenotypes but without chromosomal abnormalities or RAI1 variants. We identified pathogenic de novo variants in two cases, a nonsense variant in IQSEC2 and a missense variant in the SAND domain of DEAF1, and candidate de novo missense variants in an additional two cases. One candidate variant was located in an alpha helix of Necdin (NDN), phased to the paternally inherited allele. NDN is maternally imprinted within the 15q11.2 Prader-Willi Syndrome (PWS) region. This can help clarify NDN's role in the PWS phenotype. No definitive pathogenic gene variants were detected in the remaining SMS-like cases, but we report our findings for future comparison. This study provides information about the inheritance pattern and recurrence risk for patients with identified variants and demonstrates clinical and genetic overlap of neurodevelopmental disorders. Identification and characterization of ID-related genes that assist in development of common developmental pathways and/or gene-networks, may inform disease mechanism and treatment strategies.

PMID: 28213671 [PubMed - as supplied by publisher]

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LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.

LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.

J Pharm Biomed Anal. 2017 Feb 04;138:158-165

Authors: Kiesel BF, Shogan JC, Rachid M, Parise RA, Vendetti FP, Bakkenist CJ, Beumer JH

Abstract
The ATM kinase inhibitor AZ31 and ATR kinase inhibitor AZD6738 are in various phases of preclinical and clinical evaluation for their ability to potentiate chemoradiation. To support the preclinical evaluation of their pharmacokinetics, we developed and validated an LC-MS/MS assay for the simultaneous quantification of AZ31 and AZD6738 in mouse plasma. A "dilute and shoot" method was used to precipitate proteins from a sample volume of 50μL. Chromatographic separation was achieved using a Phenomenex Polar-RP column and a gradient mobile phase consisting of methanol-water with 0.1% formic acid. Detection was accomplished using a Waters Quattro Micro mass spectrometer in positive ionization mode. The assay utilizing 50μL sample was linear from 10 to 5000ng/mL and determined to be both accurate (-8.2 to 8.6%) and precise (<5.4% CV) and achieved the criteria for U.S. FDA guidance for bioanalytical method validation. Quantification was achieved in mouse tissue homogenate using a separate 200μL sample preparation. This LC-MS/MS assay will be essential for determining the tissue distribution and pharmacokinetics in future mouse studies.

PMID: 28213176 [PubMed - as supplied by publisher]

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A Comparison of Two Dosing Regimens of ASA Following Total Hip and Knee Arthroplasties.

A Comparison of Two Dosing Regimens of ASA Following Total Hip and Knee Arthroplasties.

J Arthroplasty. 2017 Jan 24;:

Authors: Feldstein MJ, Low SL, Chen AF, Woodward LA, Hozack WJ

Abstract
BACKGROUND: The purpose of this study was to compare short-term side effects of aspirin (ASA) 325 mg vs ASA 81 mg orally twice daily (PO BID) when used as thromboembolic prophylaxis following primary total joint arthroplasty.
METHODS: A 1-year prospective cohort study was performed on 643 primary unilateral total joint arthroplasty patients operated on by a single surgeon. Two hundred eighty-two patients were administered ASA 325 mg PO BID and 361 patients were administered ASA 81 mg PO BID for 1 month. A questionnaire assessing the side effects of ASA intake was administered 1 month postoperatively.
RESULTS: The overall rate of gastrointestinal side effects (GI upset and nausea) was 1.9%, but ASA 325 mg had a higher rate 9/282 (3.2%) than ASA 81 mg 3/361 (0.8%), P = .04. Overall GI bleeding was 0.9%, with 2/282 (0.7%) in the ASA 325 mg group, vs 4/361 (1.1%) in the ASA 81 mg group, P = .70. One patient in the ASA 81 mg group (0.3%) developed a deep vein thrombosis. No patient developed pulmonary embolism, periprosthetic joint infection, tinnitus, wheezing and/or shortness of breath, chest pain, or headaches. In the ASA 325 mg group, 9/282 (3.2%) discontinued ASA and in the ASA 81 mg group, 8/361 (2.2%) discontinued ASA, P = .47. Four patients in the ASA 325 group (1.4%) changed to ASA 81 mg.
CONCLUSION: ASA 81 mg is associated with significantly less GI distress and nausea compared with ASA 325 mg. GI bleeding was equally prevalent between the 2 dosing regimens, so patients need to be informed of this risk regardless of the ASA dose.

PMID: 28214257 [PubMed - as supplied by publisher]

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Simultaneous idiopathic bilateral sudden hearing loss - characteristics and response to treatment.

Simultaneous idiopathic bilateral sudden hearing loss - characteristics and response to treatment.

Braz J Otorhinolaryngol. 2017 Jan 24;:

Authors: Akil F, Yollu U, Yilmaz M, Yener HM, Mamanov M, Inci E

Abstract
INTRODUCTION: The aetiology of sudden hearing loss is poorly defined; however, infectious, vascular and neoplastic aetiologies are presumed to be responsible. In addition, the aetiology of bilateral sudden hearing loss is also unknown.
OBJECTIVE: The objective of this study is identify the characteristics and treatment response of simultaneous bilateral sudden hearing loss.
METHODS: This is a case-control study that practised in tertiary care academic centre. 132 patients with sudden hearing loss who were treated with systemic steroid and hyperbaric oxygen together were included. 26 patients had bilateral sudden hearing loss and 106 patients had unilateral sudden hearing loss. Patients were evaluated with clinical, audiological and radiological examinations and laboratory tests were done. Findings and response to treatment of the patients were compared.
RESULTS: The mean ages of patients with unilateral and bilateral sudden hearing loss were 42.0 years and 24.5 years respectively with a statistically significant difference (p<0.001). Immune response markers were more prevalent in bilateral sudden hearing loss. Pre-treatment audiologic thresholds were 69.1dB for unilateral sudden hearing loss and 63.3dB for the left ears and 67.6dB for the right ears for bilateral sudden hearing loss without significant difference. Post-treatment average hearing threshold in unilateral sudden hearing loss was 47.0dB and 55.4dB for the left ears and 59.0 for the right ears in bilateral sudden hearing loss. Average hearing improvement in unilateral sudden hearing loss group was significant (p<0.001) in spite of it was not significant in bilateral sudden hearing loss group for both ears. Between the groups; there was a significant difference for hearing improvement favouring unilateral sudden hearing loss (p<0.001). Tinnitus scores decreased significantly in both groups of patients (p<0.001) in spite of there was no significant difference between the groups of patients.
CONCLUSION: Patients with bilateral sudden hearing loss showed lower age, worse prognosis and higher rate of positive immune response markers. Cardiovascular risk factors seem to have an important role in the aetiology of unilateral cases whereas this importance was not present in bilateral ones.

PMID: 28214147 [PubMed - as supplied by publisher]

http://ift.tt/2lXvOJr

Repetitive transcranial magnetic stimulation and drugs for tinnitus.

Repetitive transcranial magnetic stimulation and drugs for tinnitus.

Eur Arch Otorhinolaryngol. 2017 Feb 17;:

Authors: Bilici S

PMID: 28213774 [PubMed - as supplied by publisher]

http://ift.tt/2kVFkZv

The relationship between BRAFV600E, NF-κB and TgAb expression in papillary thyroid carcinoma.

The relationship between BRAFV600E, NF-κB and TgAb expression in papillary thyroid carcinoma.

Pathol Res Pract. 2017 Jan 12;:

Authors: Li W, Ming H, Sun D, Li W, Wang D, Zhang G, Tan J

Abstract
PURPOSE: The aim of this study was to investigate the potential link between thyroglobulin antibody (TgAb) titers and papillary thyroid carcinoma (PTC) aggressiveness.
MATERIALS AND METHODS: This retrospective study included 122 patients who had undergone total thyroidectomy and neck central area lymph dissection followed by radioactive iodine (RAI) ablation for PTC between July 2012 and July 2014. The parameters included clinical characteristics of PTC, TgAb levels and tumor histopathological characteristics. Then, BRAFV600E and NF-κB expression in 113 PTC patients in our hospital were examined by immunohistochemistry.
RESULTS AND DISCUSSION: The group of TgAb-positive PTC patients more frequently presented with lymph node metastases (80.0% vs 61.2%, p=0.000), distant metastases (10.0% vs 1.9%, p=0.000), more RAI ablation treatments in their treatment history (344.4±88.2 vs 222.5±91.1, p=0.003) and imaging-documented disease (20.0% vs 7.8%, p=0.000) after two years' follow-up. We also found that protein expression levels of BRAFV600E and NF-κB were greater in TgAb-positive patients compared with TgAb-negative PTC patients (p=0.005, p=0.001). Immunoreactivity scores of BRAFV600E and NF-κB in TgAb-positive PTC patients with bilateral tumor foci, lymph node metastases, HT and imaging-documented disease was highest. Multivariate analysis revealed that lymph node metastases significantly correlated with NF-κB levels and TgAb levels (p=0.004, p=0.014).
CONCLUSION: The expression levels of BRAFV600E and NF-κB were significantly greater in TgAb-positive than in TgAb-negative PTC patients. In PTC, overexpression of NF-κB, as well as positive TgAb, may be a risk factor for cervical lymph node metastasis.

PMID: 28214213 [PubMed - as supplied by publisher]

http://ift.tt/2kVKkxa

Simultaneous idiopathic bilateral sudden hearing loss - characteristics and response to treatment.

Simultaneous idiopathic bilateral sudden hearing loss - characteristics and response to treatment.

Braz J Otorhinolaryngol. 2017 Jan 24;:

Authors: Akil F, Yollu U, Yilmaz M, Yener HM, Mamanov M, Inci E

PMID: 28214147 [PubMed - as supplied by publisher]

http://ift.tt/2lXvOJr

Association of rhinovirus with exacerbations in young children affected by cystic fibrosis: Preliminary data.

Association of rhinovirus with exacerbations in young children affected by cystic fibrosis: Preliminary data.

J Med Virol. 2017 Feb 18;:

Authors: Stelzer-Braid S, Liu N, Doumit M, D'Cunha R, Belessis Y, Jaffe A, Rawlinson WD

Abstract
Rhinovirus (RV) is a common respiratory viral infection linked to worsening of chronic respiratory diseases including cystic fibrosis (CF) and asthma. RV was tested by RT-PCR in samples (n = 465) collected from the upper (nasal swab, oropharyngeal suction and sputum) and lower (bronchoalveolar washings) respiratory tract of 110 children with CF. Air samples (n = 52) collected from the operating theatres and outpatient clinics were tested for RV. RV was found in 43% of children <5 years suffering an exacerbation, and 12% of older children (5-17 years). RV particles were detected in the air of clinic rooms. Detection of RV is important in better understanding viral infections in patients with CF. This article is protected by copyright. All rights reserved.

PMID: 28213960 [PubMed - as supplied by publisher]

http://ift.tt/2mbMk4w

Neferine Potentiates the Antitumor Effect of Cisplatin in Human Lung Adenocarcinoma Cells via a Mitochondria-mediated Apoptosis Pathway.

Neferine Potentiates the Antitumor Effect of Cisplatin in Human Lung Adenocarcinoma Cells via a Mitochondria-mediated Apoptosis Pathway.

J Cell Biochem. 2017 Feb 18;:

Authors: Sivalingam KS, Paramasivan P, Weng CF, Vijaya Padma V

Abstract
Cisplatin is one of the most potent chemotherapeutic agents for the treatment of many types of solid tumors but its efficacy is often limited by the development of resistance and dose limiting toxicity. Neferine is an alkaloid isolated from seed embryo of Nelumbo nucifera, it has recently been shown to have anticancer effects in various human cancer cell lines. The present investigation is designed to study the chemosensitizing ability of neferine with cisplatin in A549 cells. Neferine potentiates the cisplatin induced apoptosis through the exploration of characteristic apoptotic morphological changes, induced sub-G0/G1 cell cycle arrest, ROS hypergeneration, significant loss of cellular antioxidant enzymes as well as loss of mitochondrial membrane potential (ΔΨM). Furthermore our results revealed that neferine combined with cisplatin down regulate the expression of Bcl-2 and up regulate the expression of Bax, Bad, Bak, release of cytochrome C, p53 levels, then activated cleavage forms of caspase-9, caspase-3 and PARP. Moreover neferine and cisplatin combination significantly down regulated the protein levels of FAK and VEGF. In addition, we observed the activity of MMP-2 and MMP-9. Thus this study provides molecular evidence for the ROS mediated apoptosis of the combinatorial regimen of cisplatin and neferine in lung cancer cells. Thus these results suggest that using neferine with cisplatin combinatorial regimen could be potentiating the effect of cisplatin and neferine reduces the cisplatin dose requirement in cancer chemotherapy. This article is protected by copyright. All rights reserved.

PMID: 28214344 [PubMed - as supplied by publisher]

http://ift.tt/2lyi4UV

Polymeric Nanoparticles loaded with dexamethasone or α-tocopheryl succinate to prevent cisplatin-induced ototoxicity.

Polymeric Nanoparticles loaded with dexamethasone or α-tocopheryl succinate to prevent cisplatin-induced ototoxicity.

Acta Biomater. 2017 Feb 14;:

Authors: Martín-Saldaña S, Palao-Suay R, Aguilar MR, Ramírez-Camacho R, Román JS

Abstract
The aim of this work is the development of highly protective agents to be administered locally within the middle ear to avoid cisplatin-induced ototoxicity, which affects to 100% of the clinical patients at ultra-high concentrations (16 mg/kg). The protective agents are based on polymeric nanoparticles loaded with dexamethasone or α-tocopheryl succinate as anti-inflammarory and anti-apoptotic molecules. Dexamethasone and α-tocopheryl succinate are poorly soluble in water and present severe side effects when systemic administered during long periods of time. Their incorporation in the hydrophobic core of nanoparticles with the appropriate hydrodynamic properties provides the desired effects in vitro (lower cisplatin-induced toxicity, decreasing of caspase 3/7 activity, and lower IL-1β release) and in vivo (reducing the hearing loss at the local level). The local administration of the nanoparticles by bullostomy provides an adequate dose of drug without systemic interference with the chemotherapeutic effect of cisplatin.
STATE OF SIGNIFICANCE: 100% of the cancer patients receiving ultra-high doses of CDDP (16 mg/kg) suffer severe hearing loss, being a limiting factor in antineoplastic treatments. In this paper we describe the application polymeric nanoparticles loaded with dexamethasone or α-tocopheryl succinate to palliate the cisplatin ototoxicity derived from chemotherapy treatment. These new nanoparticles, that encapsulate, transport, and deliver dexamethasone or α-tocopheryl succinate in the middle ear, are able to partially prevent ototoxicity derived from high doses of CDDP. This is an interdisciplinary study in which in vitro and in vivo experiments are described and extensively discussed. The importance of the results opens an excellent opportunity to the translation to the clinic.

PMID: 28213099 [PubMed - as supplied by publisher]

http://ift.tt/2lyEO71

Reliability of noncontrast-enhancing tumor as a biomarker of IDH1 mutation status in glioblastoma.

Reliability of noncontrast-enhancing tumor as a biomarker of IDH1 mutation status in glioblastoma.

J Clin Neurosci. 2017 Feb 14;:

Authors: Lasocki A, Tsui A, Gaillard F, Tacey M, Drummond K, Stuckey S

Abstract
Isocitrate dehydrogenase 1 (IDH1) mutations in gliomas have been associated with a frontal lobe location and a greater proportion of noncontrast-enhancing tumour (nCET). The purpose of our study was to validate the utility of MRI imaging features in predicting IDH1 mutations in glioblastomas. Pre-operative MRIs of new glioblastoma patients, consisting of at least FLAIR and T1-weighted post-contrast sequences, were reviewed by a neuroradiologist based primarily on the VASARI feature set. IDH1 mutation testing was performed on all patients using immunohistochemistry. 153 patients met the inclusion criteria, of whom five had IDH1 mutations (3.3%). A frontal lobe location had equivalent frequency in both the IDH1-mutated and IDH1-wildtype cohorts (p=1.000). Three (60%) of the IDH1-mutated tumours had >33% nCET, compared to 21% of IDH1-wildtype (p=0.073). 12 tumours had a frontal lobe epicentre and >33% nCET, all being IDH1-wildtype. All five IDH1-mutated tumours had either a frontal lobe epicentre or >33% nCET, but none had both these features. Our results question the strength of the association between frontal lobe glioblastomas with substantial nCET and IDH1 mutations, as these features are also relatively frequent in IDH1-wildtype tumours, which are much more common. MRI is thus more useful for ruling out an IDH1 mutation rather than strongly suggesting its presence: if a particular glioblastoma does not have a frontal lobe epicentre and has less than 33% nCET, it can be predicted to be IDH1-wildtype with a high degree of confidence.

PMID: 28214089 [PubMed - as supplied by publisher]

http://ift.tt/2lvW2BK

A case of seropositive autoimmune autonomic ganglionopathy with diffuse esophageal spasm.

A case of seropositive autoimmune autonomic ganglionopathy with diffuse esophageal spasm.

J Clin Neurosci. 2017 Feb 14;:

Authors: Morimoto N, Takahashi S, Inaba T, Takamiya M, Kageyama Y, Morimoto M, Takahashi Y, Nishimura H, Nakane S, Abe K

Abstract
Autoimmune autonomic ganglionopathy (AAG) is an immune-mediated disorder that leads to various autonomic failures associated with anti-ganglionic acetylcholine receptor antibodies (anti-gAChR-Abs). Diffuse esophageal spasm (DES) is an uncommon esophageal motility disorder. We herein report the case of a 68-year-old woman with DES as a partial symptom of AAG. She presented with chronic esophageal transit failure, constipation, and numbness of the hands and feet, Adie's pupil, thermal hypoalgesia, and decreased deep tendon reflexes. Right sural nerve biopsy showed significantly decreased numbers of small myelinated fibers. Barium swallowing X-ray showed repetitive simultaneous contractions indicating DES in the esophagus. Gastrointestinal endoscopy and CT image showed a dilated esophageal lumen and liquid effusion. Simultaneously, serum anti-gAChR-α3-Ab indicating AAG was detected. After pulse intravenous methylprednisolone (IVMP) and intravenous immunoglobulin therapy (IVIg), the bolus progression and liquid effusion improved, suggesting that DES is an important gastrointestinal symptom of AAG.

PMID: 28214088 [PubMed - as supplied by publisher]

http://ift.tt/2lyjzCn

[Mucosal alterations-what is the cause?]

[Mucosal alterations-what is the cause?]

HNO. 2017 Feb 17;:

Authors: Hofauer B, Schulze TR, Knopf A, Stimmer H, Graf S, Hofauer BG

PMID: 28213702 [PubMed - as supplied by publisher]

http://ift.tt/2m0nsxp

A case of IV degree on acute radiation dermatitis in China.

A case of IV degree on acute radiation dermatitis in China.

Int J Surg Case Rep. 2017 Feb 02;32:19-21

Authors: Shen Z, Chen YH, Chen Y, Chen Y, Lv Z, Gao HC

Abstract
This report investigates the nursing procedure of a case of adjuvant therapy of rectal cancer on IV degree of acute radiation dermatitis patients in the penis and scrotum junction. The lesion degree gradually increased. Fixation of the dressing was difficult in the penis and scrotum junction. The concept of wet healing with new dressings was used in patient. The silver ion dressings were used in inhibiting infection, and the wound was covered by the rimmed foam dressings. When it comes to the shaping period, water gel transparent paste was applied instead to cover the wound. The patient was just into the surgical treatment in the wound healed after six days.

PMID: 28214397 [PubMed - as supplied by publisher]

http://ift.tt/2m0ebFr

Totally extra-peritoneal repair for acute incarcerated femoral hernia with intestinal obstruction.

Totally extra-peritoneal repair for acute incarcerated femoral hernia with intestinal obstruction.

Int J Surg Case Rep. 2017 Jan 17;32:16-18

Authors: Kim G, Yan So JB, Shabbir A

Abstract
INTRODUCTION: Femoral hernias frequently present with incarceration, resulting in obstruction and strangulation. Laparoscopic groin hernia repairs have been shown in the elective setting to be an effective alternative to open repair. Acute incarceration of groin hernia with obstruction, though previously seen as a relative contraindication, has been increasingly repaired with minimally invasive techniques, with the potential benefit of avoiding the morbidity associated with a laparotomy.
PRESENTATION OF CASE AND DISCUSSION: We describe a case of an acutely incarcerated femoral hernia with intestinal obstruction that was repaired using the totally extra-peritoneal approach. A releasing incision was performed to facilitate reduction of hernia prior to mesh repair. Diagnostic laparoscopy through a separate incision was then performed.
CONCLUSION: This modification of the TEP repair technique for the acutely incarcerated and obstructed femoral hernia serves to minimise potential contamination by keeping the pre-peritoneal plane strictly separate from the intra-peritoneal space.

PMID: 28214396 [PubMed - as supplied by publisher]

http://ift.tt/2l962Ap

An unusual cause of severe dyspnea: A laryngeal live leech: Case report.

An unusual cause of severe dyspnea: A laryngeal live leech: Case report.

Int J Surg Case Rep. 2017 Jan 25;32:9-11

Authors: Anajar S, Ansari R, Hassnaoui J, Abada R, Roubal M, Mahtar M

Abstract
INTRODUCTION: Foreign bodies in the upper airways are one of the most challenging otolaryngology emergencies, leeches present a very rare cause of airway foreign bodies around the world.
CASE REPORT: A 6-year-old girl was referred to our otolaryngology department at a tertiary university hospital with a severe dyspnea and hemoptysis. Nasofibroscopy revealed a dark living leech in the supraglottic area which extends to the glottis. The patient was urgently admitted to the operating room, the leech was grasped and removed with a foreign body forceps with a full length of more than 6cm. All symptoms were relieved post operatively and she was discharged one day later.
CONCLUSION: Leeches should be suspected as an airway foreign body in patients with a recent history of drinking from stream water. Prevention remains the best treatment for such cases based simply on hygiene measures like not drinking stream water directly and filtering drinking water before it is used.

PMID: 28213068 [PubMed - as supplied by publisher]

http://ift.tt/2m0hdK2

Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report.

Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report.

Int J Surg Case Rep. 2017 Jan 19;32:12-15

Authors: Akbar SA, Tunio MA, AlShakweer W, AlObaid A, AlAsiri M

Abstract
INTRODUCTION: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked.
CASE PRESENTATION: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma. Patient underwent left inguinal lymph node dissection. Histopathology confirmed metastatic endometrial adenocarcinoma, positive for cytokeratin (CK-7), estrogen receptor (ER) and progesterone receptors (PR), negative for CK-20 and CDX2. Following the post-surgery recovery, she was given extended field radiation therapy to para-aortic, pelvis and bilateral inguinal lymph nodes with concurrent cisplatin chemotherapy followed by high dose rate brachytherapy.
CONCLUSION: Inguinal lymph nodes as delayed site of metastasis in early endometrial carcinoma is extremely rare entity. Incorporation of FDG-PET during the preoperative screening of inguinal nodes may be helpful. The impact of lymph node dissection and adjuvant radiation therapy on survival needs to be established.

PMID: 28213066 [PubMed - as supplied by publisher]

http://ift.tt/2kVIT1r

[Impact of Her2 and BRCA1/2 status in high-dose chemotherapy and autologous stem cells transplantation in the treatment of breast cancer: The Institut Paoli Calmettes' experience].

[Impact of Her2 and BRCA1/2 status in high-dose chemotherapy and autologous stem cells transplantation in the treatment of breast cancer: The Institut Paoli Calmettes' experience].

Bull Cancer. 2017 Feb 14;:

Authors: Boudin L, Chabannon C, Sfumato P, Sabatier R, Bertucci F, Tarpin C, Provansal M, Houvenaeghel G, Lambaudie E, Tallet A, Resbeut M, Charafe-Jauffret E, Calmels B, Lemarie C, Boher JM, Extra JM, Viens P, Gonçalves A

Abstract
INTRODUCTION: Studies evaluating chemotherapy high dose chemotherapy with autologous haematopoietic stem cell transplantation (HDC-ACSH) in the treatment of metastatic (MBC), locally advanced (LABC) and inflammatory (IBC) breast cancer have in common lack of biomarker information, in particular the HER2 status.
PATIENTS AND METHODS: All consecutive female patients treated for breast cancer with HDC and AHSCT at Institut Paoli Calmettes between 2003 and 2012 were included. Patients were categorized in three subtypes based on hormonal receptor (HR) and HER2 status of the primary tumor: luminal, (HR+/HER2-), HER2 (HER2+, any HR) and triple negative (TN) (HER2- and HR-). The main objective was the analysis of overall survival (OS) according to the IHC subtypes.
RESULTS: Three hundred and seventy-seven patients were included. For MBC, the TN subtype appeared to have the worst prognosis with a median OS of 19.68 months (95 % CI 11.76-44.4) compared to 44.64 months (95 % CI 40.32-67.56) for the luminal subtype and a median OS not reached for the HER2 subtype (P<0.01). For IBC, HER2 subgroup appeared to have the best prognosis with a 5-year OS of 89 % (95 % CI 64-97) compared to 57 % (95 % CI 33-76) for the TN subgroup (HR 5.38, 95 % CI 1.14-25.44; P=0.034). For CSLA, luminal subgroup appeared to have the best prognosis with a 5-year OS of 92 % (95 % CI 71-98) against 75 % (95 % CI 46-90) for HER 2 subtype and 70 % (95 %CI 97-88) for TN subtype (P=0.301).
CONCLUSION: The HDC-ACSH does not change the prognosis value of IHC subtype in breast cancer patients.

PMID: 28214007 [PubMed - as supplied by publisher]

http://ift.tt/2kMkTgo

[Conduct of epidemiologic studies in French cancer survivors: Methods, difficulties encountered and solutions provided. Lessons learned from the SIMONAL study on long-term toxicities after non-Hodgkin lymphoma treatment].

[Conduct of epidemiologic studies in French cancer survivors: Methods, difficulties encountered and solutions provided. Lessons learned from the SIMONAL study on long-term toxicities after non-Hodgkin lymphoma treatment].

Bull Cancer. 2017 Feb 14;:

Authors: Anthony S, Hebel P, Garrel A, Oliveri V, Thieblemont C, Ribrag V, Tilly H, Haioun C, Casasnovas RO, Morschhauser F, Feugier P, Delarue R, Ysebaert L, Sebban C, Broussais F, Damaj G, Nerich V, Jais JP, Salles G, Henry-Amar M, Mounier N

Abstract
INTRODUCTION: Since the introduction of targeted therapies, specific lymphoma mortality has decreased. Possible long-term toxicities, however, are not known yet. This article describes the implementation of the SIMONAL study that investigates the hypothesis of an overconsumption of care after lymphoma treatment with a 10-year follow-up.
METHODS: After the mandatory regulatory steps (CCTIRS and CNIL) the vital status and address of 5247 patients treated in 131 French centers were retrieved using a secure web portal, in order to send a quality of life after lymphoma questionnaire. After an additional vital status validation request at the center for epidemiologic research and population health (CESP), the questionnaires were sent. Double data entry was performed on the collected data and a request to access data from France's public health insurance scheme information system (SNIIRAM) was formulated.
RESULTS: Retrieval of the addresses via the portal has been slow and multiple reminders were needed. The CESP identified 9.4 % additional deaths not known by the treatment centers. Of the 3391 questionnaires sent, the response rate was 50%. A comparison between the responders and non-responders revealed no demographic differences but showed that the responders were more often treated with targeted drugs as they were included in more recent trials.
DISCUSSION: Logistic and information technology (IT) aspects rendered the implementation of the SIMONAL study more complex, time consuming and costly. However, using the collected data, many future research questions will be addressed.

PMID: 28214006 [PubMed - as supplied by publisher]

http://ift.tt/2lXiDYN

[Review of national and international guidelines for sentinel lymph node biopsy and complementary axillary dissection in breast cancer].

[Review of national and international guidelines for sentinel lymph node biopsy and complementary axillary dissection in breast cancer].

Bull Cancer. 2017 Feb 14;:

Authors: Vincent L, Margueritte F, Uzan J, Owen C, Seror J, Pouget N, Guillot E, Rouzier R

Abstract
Management of breast cancer is based on national and international guidelines. These are defined on evidence-based medicine. The main purpose of this review is to compare the different guidelines for sentinel lymph node biopsy and completion axillary dissection after positive sentinel lymph node biopsy. This review of breast cancer guidelines led to identify consensus, but in some specific situations, they differ. The guidelines cannot be applied to all clinical cases, mandatoring multidisciplinary meetings are essential.

PMID: 28214005 [PubMed - as supplied by publisher]

http://ift.tt/2lw0PmJ

A Historical Glance at the Arabo-Islamic Surgical Instruments During the Ages.

A Historical Glance at the Arabo-Islamic Surgical Instruments During the Ages.

World J Surg. 2017 Feb 17;:

Authors: Tsoucalas G, Sgantzos M

Abstract
Arabo-Islamic physicians demonstrated exceptional skill and innovation in surgery, by having used the instruments introduced by ancient Greeks and Greco-Roman surgeons. In many cases they have manufactured their own innovative designs promoting further the success of the difficult surgical operations of their era. The surgical instruments and the surgeon's boxes, used to regularise the plethora of the metallic items, were decorated with fine designs, in order to depict the Arab civilisation. For the first time surgery became a separate medical art, while Arabo-Islamic medicine re-introduced ancient Greek and Byzantine surgery to the world.

PMID: 28213663 [PubMed - as supplied by publisher]

http://ift.tt/2lyl6sf

Adenoid bacterial colonization in a paediatric population.

Adenoid bacterial colonization in a paediatric population.

Eur Arch Otorhinolaryngol. 2017 Feb 18;:

Authors: Subtil J, Rodrigues JC, Reis L, Freitas L, Filipe J, Santos A, Macor C, Duarte A, Jordao L

Abstract
Adenoids play a key role in both respiratory and ear infection in children. It has also been shown that adenoidectomy improves these symptoms in this population. The main goal of the present study was to evaluate adenoid bacterial colonization and document a possible relation with infectious respiratory disease. A prospective observational study was designed to evaluate the proposed hypothesis in a paediatric population submitted to adenoidectomy by either infectious or non-infectious indications and compare these two cohorts. A total of 62 patients with ages ranging from 1 to 12 years old were enrolled in the study. Adenoid surface, adenoid core and middle meatus microbiota were compared. A close association between adenoid colonization and nasal infection was found, supporting that adenoids may function as bacterial reservoir for upper airway infection. The obtained results also contribute to explain the success of adenoidectomy in patients with infectious indications.

PMID: 28213779 [PubMed - as supplied by publisher]

http://ift.tt/2kVTj1p

Response to the letter to the editor regarding "Comparison of the anatomic and hearing outcomes of cartilage type 1 tympanoplasty in pediatric and adult patients".

Response to the letter to the editor regarding "Comparison of the anatomic and hearing outcomes of cartilage type 1 tympanoplasty in pediatric and adult patients".

Eur Arch Otorhinolaryngol. 2017 Feb 17;:

Authors: Yilmaz MS

PMID: 28213778 [PubMed - as supplied by publisher]

http://ift.tt/2kVL7Ov

Reply to the letter to the editor concerning: 'Fat-plug myringoplasty of ear lobule vs abdominal donor sites'.

Reply to the letter to the editor concerning: 'Fat-plug myringoplasty of ear lobule vs abdominal donor sites'.

Eur Arch Otorhinolaryngol. 2017 Feb 17;:

Authors: Acar M, Yazıcı D, San T, Muluk NB, Cingi C

PMID: 28213777 [PubMed - as supplied by publisher]

http://ift.tt/2kVPV6t

Post-tonsillectomy pain after using bipolar diathermy scissors or the harmonic scalpel: a randomised blinded study.

Post-tonsillectomy pain after using bipolar diathermy scissors or the harmonic scalpel: a randomised blinded study.

Eur Arch Otorhinolaryngol. 2017 Feb 17;:

Authors: Arbin L, Enlund M, Knutsson J

Abstract
OBJECTIVE: To compare the postoperative pain following bipolar diathermy scissors tonsillectomy (higher temperature dissection) with harmonic scalpel tonsillectomy (lower temperature dissection).
METHODS: Sixty patients aged 7-40 years planned for tonsillectomy with no other concurrent surgery were randomised to either bipolar diathermy scissors or harmonic scalpel as surgical technique. Blinded to the surgical technique, the patients recorded their pain scores (VAS, 0-10) at awakening and the worst pain level of the day in the postoperative period. All intake of pain medication was also recorded.
RESULTS: No statistically significant differences were found between the two groups regarding postoperative pain levels or consumption of pain medication.
CONCLUSION: Usage of the harmonic scalpel does not render less postoperative pain following tonsillectomy when compared with usage of the bipolar diathermy scissors.

PMID: 28213775 [PubMed - as supplied by publisher]

http://ift.tt/2kVxQWg

Repetitive transcranial magnetic stimulation and drugs for tinnitus.

Repetitive transcranial magnetic stimulation and drugs for tinnitus.

Eur Arch Otorhinolaryngol. 2017 Feb 17;:

Authors: Bilici S

PMID: 28213774 [PubMed - as supplied by publisher]

http://ift.tt/2kVFkZv

A Rare Presentation of an Enterogenous Cyst as an Intra-axial Pontine Lesion.

A Rare Presentation of an Enterogenous Cyst as an Intra-axial Pontine Lesion.

World Neurosurg. 2017 Feb 14;:

Authors: Li T, Wu X, Zhang Y

Abstract
A 56-year-old man was admitted to our hospital with intermittent right facial numbness for one year and walking instability for six months. Magnetic resonance imaging revealed an ovoid and well-demarcated intra-axial pontine lesion. Cyst fenestration and biopsy were carried out and the diagnosis of enterogenous cyst was made by MRI and pathologic findings. Preoperative symptoms resolved completely three months after surgery and no evidence of recurrence was found during 3 years of follow-up. Although total resection of enterogenous cysts is recommended, cyst fenestration may be useful if the cyst is adherent to vital neurovascular structures.

PMID: 28213198 [PubMed - as supplied by publisher]

http://ift.tt/2kMjff3

Epileptic seizures in patients following surgical treatment of acute subdural hematoma - incidence, risk factors, patient outcome and development of a new scoring system for prophylactic antiepileptic treatment (GATE 24-score).

Epileptic seizures in patients following surgical treatment of acute subdural hematoma - incidence, risk factors, patient outcome and development of a new scoring system for prophylactic antiepileptic treatment (GATE 24-score).

World Neurosurg. 2017 Feb 14;:

Authors: Won SY, Dubinski D, Herrmann E, Cuca C, Strzelczyk A, Seifert V, Konczalla J, Freiman TM

Abstract
OBJECT: Clinically evident or subclinical seizures are common manifestation in acute subdural hematoma (aSDH); however, there is a paucity of research investigating the relationship between seizures and aSDH. The purpose of this study is, firstly to determine incidence, predictors of seizures and secondly establish a guideline in patients with aSDH to standardize the decision for prophylactic antiepileptic treatment.
METHOD: The author analyzed 139 patients with aSDH treated from 2007 until 2015. Baseline characteristics and clinical findings including Glasgow coma scale (GCS) at admission, 24 hours after operation, timing of operation, anticoagulation, Glasgow outcome scale (GOS) at hospital discharge and after 3 months were analyzed. Multivariate logistic regression analysis was performed to detect independent predictors of seizures and a scoring system was developed.
RESULTS: Of 139 patients, overall incidence of seizures was 38%, preoperatively 16% and postoperatively 24%. Ninety percent of patients with preoperative seizures were seizure-free after operation for 3 months. Independent predictors of seizures were GCS < 9 (OR 3.3), operation after 24 hours (OR 2.0) and anticoagulation (OR 2.2). Patients with seizures had a significant higher rate of unfavorable outcome at hospital discharge (p=0.001) and in 3 month follow-up (p=0.002). Furthermore a score system (GATE-24) was developed. In patients with GCS < 14, anticoagulation or surgical treatment 24 hours after onset a prophylactic antiepileptic treatment is recommended.
CONCLUSION: Occurrence of seizures affected severity and outcomes after surgical treatment of aSDH. Therefore, seizure prophylaxis should be considered in high-risked patient based on GATE-24 score to promote better clinical outcome.

PMID: 28213197 [PubMed - as supplied by publisher]

http://ift.tt/2lXfV5N

Rate and risk factors of shunt revision in pediatric hydrocephalus patients - population-based study.

Rate and risk factors of shunt revision in pediatric hydrocephalus patients - population-based study.

World Neurosurg. 2017 Feb 14;:

Authors: Tervonen J, Leinonen V, Jääskeläinen JE, Koponen S, Huttunen TJ

Abstract
BACKGROUND: Ventriculoperitoneal shunt (VPS) is a common treatment for patients with hydrocephalus (HC). However, it carries a risk for complications which may require further revisions. We studied the surgical outcome of pediatric hydrocephalus patients in a population-based setting.
METHODS: A total of 80 patients of age ≤16 years old who required VPS due to HC were included, and their medical charts and imaging findings were studied.
RESULTS: The mean age at the time of initial shunt placement was 3.2 years (SD 4.5) and the mean follow-up time was 3.3 (SD 2.9) years and 57% were males. Half of the patients underwent shunt revision with the mean time to first revision of 8 months. Patients ≤6 months had higher shunt revision rate when compared to the older ones (p<0.001). The most common causes for HC requiring VPS were tumors (27.5%), congenital defects (CD) (22.5%), and intraventricular hemorrhage (IVH) (19%). In IVH and CD patient group revision rates were 67 % (p=0.017) and 72% (p=0.016), respectively, as compared to tumor group (32%). Programmable valves (56%) were more common than non-programmable valves but there was no significant difference in shunt survival (p=0.632). The mean biparietal measure change between pre- and postoperative images was in non-revised group +0.9mm and +6.6mm in revision group (p=0.003).
CONCLUSIONS: Half of the shunted pediatric HC patients required revision. Age ≤6months, IVH, CD etiologies for HC were associated with increased the risk of shunt revision. Most of the revisions were done during the first year after the initial shunting.

PMID: 28213196 [PubMed - as supplied by publisher]

http://ift.tt/2l98DtV

Blunt Traumatic Brain Injury Patients: A Role for CT Angiography of the Head to Evaluate Non-Traumatic Etiologies?

Blunt Traumatic Brain Injury Patients: A Role for CT Angiography of the Head to Evaluate Non-Traumatic Etiologies?

World Neurosurg. 2017 Feb 14;:

Authors: Nguyen H, Doan N, Gelsomino M, Shabani S

Abstract
BACKGROUND: In the setting of trauma, the etiology of intracranial hemorrhage (ICH) is frequently attributed to the physical, traumatic event. Caution should still be directed towards non-traumatic (or spontaneous) etiologies responsible for the trauma, such as hypertension, cerebral amyloid angiopathy, aneurysms, vascular malformation, and hemorrhagic infarcts. The role for immediate CT angiography (CTA) remains controversial to evaluate for non-traumatic etiologies.
METHODS: A systematic review of the available literature in Medline PubMed database.
RESULTS: With the available literature, only 12 patients with TBI received CTA head which either revealed a vascular malformation and/or altered clinical management due to concerns of a vascular malformation. The ICH in 11 patients were attributed to rupture of a cerebral aneurysm; the other patient received a diagnostic angiogram that was negative.
CONCLUSION: ICH in TBI patients appears to be vastly associated with the traumatic event. Only rare cases have been attributed to aneurysmal rupture. None have been associated with arteriovenous malformation. Nevertheless, clinical vigilance remains reasonable, especially in younger patients and those with hemorrhage within the subarachnoid cisterns or Sylvain fissure.

PMID: 28213195 [PubMed - as supplied by publisher]

http://ift.tt/2l8Z3Y4

Subcortical mapping using an electrified CUSA in pediatric supratentorial surgery.

Subcortical mapping using an electrified CUSA in pediatric supratentorial surgery.

World Neurosurg. 2017 Feb 14;:

Authors: Roth J, Korn A, Bitan-Talmor Y, Kaufman R, Ekstein M, Constantini S

Abstract
BACKGROUND: Intraoperative electrophysiology is increasingly used for various lesion resections, both in adult and pediatric brain surgery. Subcortical mapping is often used in adult surgery when lesions lie in proximity to the corticospinal tract (CST). We describe a novel technique of continuous subcortical mapping using an electrified Cavitron UltraSonic Aspirator (CUSA) in children with supratentorial lesions.
METHODS: We evaluated the method of subcortical mapping using a CUSA as a stimulation probe. Included in this study were children (<18 years of age) with supratentorial lesions in proximity to the CST in which the CUSA stimulator was applied. Data was collected retrospectively.
RESULTS: 11 children were included. Lesions were located in the thalamus (3), basal-ganglia (2), lateral ventricle (1), and convexity (5). Lesions included low-grade gliomas (6), AVM (1), cavernoma (1), cortical dysplasia (1), ependymoma grade II (1), and high-grade glioma (1). Seven patients had positive mapping responses to CUSA-based stimulation at various stimulation intensities. These responses led to a more limited resection in 5 cases. There were no complications related to the mapping technique.
CONCLUSION: Continuous CUSA based subcortical stimulation is a feasible mapping technique for assessing proximity to the CST during resection of supratentorial lesions in children. Future studies should be performed to better correlate the current threshold for eliciting a motor response with the distance from the CST as well as the effect of age on this technique.

PMID: 28213194 [PubMed - as supplied by publisher]

http://ift.tt/2l98qqN

Anterior surgical fixation for cervical spine flexion-distraction injuries.

Anterior surgical fixation for cervical spine flexion-distraction injuries.

World Neurosurg. 2017 Feb 14;:

Authors: Jack A, Hardy-St-Pierre G, Wilson M, Choy G, Fox R, Nataraj A

Abstract
BACKGROUND: Optimal surgical management for flexion-distraction cervical spine injuries remains controversial with current guidelines recommending anterior, posterior, and circumferential approaches. Here, we determined the incidence of and examined risk factors for clinical and radiographic failure in patients with one segment cervical distraction injuries having undergone anterior surgical fixation.
METHODS: A retrospective review of 57 consecutive patients undergoing anterior fixation for subaxial flexion-distraction cervical injuries between 2008-2012 at our institution was performed. The primary outcome was the number of patients requiring additional surgical stabilization and/or radiographic failure. Data collected inlcuded age, gender, mechanism and level of injury, facet pattern injury, and vertebral endplate fracture.
RESULTS: A total of six patients failed clinically and/or radiographically (11%). Four patients (7%) required additional posterior fixation. Although two other patients identified met radiographic failure criteria, at follow-up they had fused radiographically, were stable clinically, and no further treatment was pursued. Progressive kyphosis and translation were found to be significantly correlated with need for revision (p<0.05 and p=0.02, respectively). No differences were identified for all other clinical and radiological factors assessed, including unilateral or bilateral facet injury, facet fracture, and endplate fracture.
CONCLUSION: This study contributes to the growing body of evidence supporting anterior fixation alone for flexion-distraction injuries. Findings suggest that current measurements of radiographic failure including segmental translation and kyphosis may predict radiographic failure and need for further surgical stabilization in some patients. Future follow-up studies assessing for independent risk factors for anterior approach failure with a validated predictive scoring model should be considered.

PMID: 28213193 [PubMed - as supplied by publisher]

http://ift.tt/2kVUqhx

Trans-Frontal-Sinus-Subcranial Approach to Olfactory Groove Meningiomas: Surgical Results, Clinical and Functional Outcome in A Consecutive Series of 21 Patients.

Trans-Frontal-Sinus-Subcranial Approach to Olfactory Groove Meningiomas: Surgical Results, Clinical and Functional Outcome in A Consecutive Series of 21 Patients.

World Neurosurg. 2017 Feb 14;:

Authors: Barzaghi LR, Spina A, Gagliardi F, Boari N, Mortini P

Abstract
BACKGROUND: The trans-frontal-sinus-subcranial approach (TFSSA) allows for direct exposure and removal of olfactory groove meningiomas (OGMs), without any brain retraction. Compared to other skull base approaches (like fronto-orbito-basal, transbasal, subcranial, fronto-orbito-zygomatic and one-and-half approach), it could offer the same advantages but it is less invasive.
OBJECT: We report the results in a series of 21 consecutive patients harboring OGMs and operated through TFSSA, in order to propose a viable alternative approach.
METHODS: Mean maximum tumor diameter was 45.9 ± 3.4 mm (25-70). Aim of surgery was Simpson Grade I removal. Surgical, clinical and functional outcomes were reported. Mean follow-up was 87 ± 7 months (36-176).
RESULTS: In all patients, MRI after surgery confirmed complete tumor removal. The recurrence-free survival rate was 100% and 85.7% at 5 and 10 years, respectively. Surgery-related mortality and major morbidity were 0 and 4.8%, respectively. Risk of anosmia significantly correlates with meningioma size (p<.001) and smell sense was preserved only in patients harboring tumors less than 4 cm in maximum diameter (4/7 57.1%). A significant improvement of Mini Mental Standard Examination score was recorded at follow-up (p<.001) and no patients worsened their cognitive profile. Visual function improved in 7/8 (87.5%). Karnofsky Performance Scale after surgery significantly increased (p<.001). According to the Glasgow outcome score, good outcome was achieved in 20 patients (95.2%).
CONCLUSIONS: Based on reported results, TFSSA allows complete tumor removal with good outcome and low complication rate. It may be proposed as a safe and effective approach to treat large and giant OGMs.

PMID: 28213192 [PubMed - as supplied by publisher]

http://ift.tt/2lvQ0kx

Microneurosurgical Management of Posterior Communicating Artery Aneurysm- A contemporary series from Helsinki.

Microneurosurgical Management of Posterior Communicating Artery Aneurysm- A contemporary series from Helsinki.

World Neurosurg. 2017 Feb 14;:

Authors: Thiarawat P, Jahromi BR, Kozyrev DA, Intarakhao P, Teo MK, Choque-Velasquez J, Hernesniemi J

Abstract
OBJECTIVE: Our purposes are to analyze microsurgical techniques and to determine correlations between microsurgical techniques with the radiographic findings in the microneurosurgical treatment of the posterior communicating artery aneurysms (PCoAAs).
METHODS: The authors retrospectively analyzed radiographic findings and videos of surgery in 64 patients with PCoAAs who underwent microsurgical clipping by the senior author from August 2010-2014.
RESULTS: From 64 aneurysms, 30 (47%) had SAH that necessitated the lamina terminalis fenestration (odds ratio [OR], 67.67; P < 0.001) and the Liliequist's membrane fenestration (OR, 19.62; P < 0.001). The low-lying aneurysms significantly necessitated the coagulation of the dura covering the anterior clinoid process (ACP) (OR, 7.43; P = 0.003) or anterior clinoidectomy (OR, 91.0; P < 0.001). We preferred straight clips in 45 (83%) of 54 postero-lateral projecting aneurysms (OR, 45.0; P < 0.001) but preferred curved clips for postero-medial projecting aneurysms (OR, 6.39; P = 0.008). The mean operative time from the brain retraction to the final clipping was 17 min 43 sec. Postoperative CTA revealed complete occlusion of 60 (94%) aneurysms. Three (4.6%) patients with SAH suffered postoperative lacunar infarction.
CONCLUSION: For ruptured aneurysms, the lamina terminalis and the Liliequist's membrane fenestration are useful for additional CSF drainage. For low-lying aneurysm, coagulation of the dura covering the ACP or tailored anterior clinoidectomy might be necessary for exposing the proximal aneurysm neck. Type of clips depends on the direction of projection. The microsurgical clipping of the PCoAAs can achieve good immediate complete occlusion rate with low postoperative stroke rate.

PMID: 28213191 [PubMed - as supplied by publisher]

http://ift.tt/2lvNJWt

Consolidative local therapy in oligometastatic patients - Authors' reply.

Consolidative local therapy in oligometastatic patients - Authors' reply.

Lancet Oncol. 2017 Feb;18(2):e62

Authors: Gomez D, Swisher S, Heymach J

PMID: 28214416 [PubMed - in process]

http://ift.tt/2lX6UcH

Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis.

Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis.

Rhinology. 2017 Feb 18;:

Authors: Leason SR, Barham HP, Oakley G, Rimmer J, DelGaudio JM, Christensen JM, Sacks R, Harvey RJ

Abstract
INTRODUCTION: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS). The association of GORD with CRS is systematically assessed from the medical literature.
METHODOLOGY: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included. Studies without a control group, case reports and review articles were excluded.
RESULTS: The search returned 958 records, with an additional 10 found from bibliographic lists; this produced 32 studies. The included studies (n=32) consisted of studies reporting pathogenic factors (n=20), epidemiological association (n=8), prognostic interactions (n=3), and a combination of these outcomes (n=1). Potential pathogenic roles for GORD in CRS were supported; CRS subjects had greater prevalence of intranasal Helicobacter pylori and acid reflux than subjects without CRS. CRS is more prevalent in GORD sufferers than those without GORD. Evidence is conflicting for GORD as a factor in CRS treatment failure.
CONCLUSION: The results support a significant association of GORD with CRS. Physicians should be cognizant of the potential for acid and non-acid reflux as a driving factor in CRS.

PMID: 28214353 [PubMed - as supplied by publisher]

http://ift.tt/2mbCKyA

Cancer stem cell, cytokeratins and epithelial to mesenchymal transition markers expression in oral squamous cell carcinoma derived from ortothopic xenoimplantation of CD44(high) cells.

Cancer stem cell, cytokeratins and epithelial to mesenchymal transition markers expression in oral squamous cell carcinoma derived from ortothopic xenoimplantation of CD44(high) cells.

Pathol Res Pract. 2016 Dec 23;:

Authors: de Andrade NP, Rodrigues MF, Rodini CO, Nunes FD

Abstract
Oral squamous cell carcinoma (OSCC) is the most prevalent neoplasia of oral cavity worldwide and prognosis remains unchanged in decades. Recently, different authors reported that head and neck squamous cell carcinomas have a subpopulation of tumor initiating cells that apparently correspond to cancer stem cells (CSC) and are also responsible for tumor growth and metastasis. The purpose of the present study was to investigate the microscopic and phenotypic characteristics of OSCC tumors induced after orthotopic xenoimplantation of SCC9(WT) cell line and CSC-enriched subpopulation isolated from SCC9 cell line based on high expression of the putative CSC marker CD44. Different numbers of FACS-sorted SCC9 CD44(high) and CD44(low) cells as well as SCC9(WT) (wild type) were transplanted into the tongue of BALB/C nude (NOD/SCID) mice to evaluate their tumorigenic potential. Sixty days post-induction, tumors were morphologically characterized and immunostained for CSC markers (CD44, Nanog and Bmi-1), epithelial-mesenchymal transition (Snail, Slug) and epithelial differentiating cell markers (cytokeratins 4, 13, 15, 17 and 19), as well as E-cadherin and β-catenin. The data presented here shows that SCC9 CD44(high) cells have higher ability to form tumors than SCC9 CD44(low) cells, even when significantly lower numbers of SCC9 CD44(high) cells were transplanted. Immunoassessment of tumors derived from SCC9 CD44(high) cells revealed high expression of cytokeratin CK19, β-catenin, E-cadherin and CD44, and negative or low expression of CK17, CK4, CK15, CK13, Nanog, Bmi-1, Snail and Slug. While tumors derived from SCC9(WT) showed high expression of CK17, CK19, CD44, Nanog, Bmi-1, Snail and Slug, and negative or low expression of CK4, CK15, CK13, β-catenin and E-cadherin. Thus, SCC9 CD44(high) cells were highly tumorigenic, capable of originating heterogeneous tumors and these tumors have a immunohistochemical profile different from those formed by the wild type cell line.

PMID: 28214216 [PubMed - as supplied by publisher]

http://ift.tt/2lXfCHZ

Validation of the University of Washington Quality of Life Chinese Version (UWQOL-C) for head and neck cancer patients in Taiwan.

Validation of the University of Washington Quality of Life Chinese Version (UWQOL-C) for head and neck cancer patients in Taiwan.

J Formos Med Assoc. 2017 Feb 14;:

Authors: Lee YH, Lai YH, Yueh B, Chu PY, Chen YJ, Chen SC, Wang CP

Abstract
BACKGROUND/PURPOSE: The purposes of this three-phase study were to: (1) translate and evaluate the burden, content, and face validity of the Chinese version of the University of Washington Quality of Life Scale, version 4 (UWQOL-v4-C); and (2) examine the psychometric properties of the UWQOL-v4-C in oral cancer and laryngeal cancer patients in Taiwan.
METHODS: This instrument translation and validation study was part of a major research project. The first phase of this study developed and validated the content of the UWQOL-v4-C. The second phase sought to validate the internal consistency, reliability, and construct and discriminant validity in two major groups of head and neck cancer (HNC) patients: oral cavity cancers (n=109) and laryngeal cancer (n=102). Construct validity was measured using theoretically supported correlations between the UWQOL and related constructs. Discriminant validity was also assessed. In the third phase, test-retest reliability of UWQOL-v4-C was examined through the 1-week interval in another group of HNC patients (n=50).
RESULTS: The translated UWQOL-v4-C demonstrated satisfactory face validity, content validity, and minimal patient burden. Additionally, the UWQOL-v4-C showed excellent construct validity in patient testing, supported by significant correlations between the UWQOL-v4-C and hypothesized constructs, including generic measures of QOL and performance status. The developed scale correlated inversely with symptom severity and psychological distress. Discriminant validity was seen in patients with different cancer diagnoses, stages, and treatments. Finally, excellent stability was supported by a 1-week test-retest reliability of 0.88.
CONCLUSION: The UWQOL-v4-C was a brief, low-burden, and valid instrument to measure the QOL in Chinese-speaking HNC patients in Taiwan.

PMID: 28214178 [PubMed - as supplied by publisher]

http://ift.tt/2mbs42U

Japanese guidelines for allergic rhinitis 2017.

Japanese guidelines for allergic rhinitis 2017.

Allergol Int. 2017 Feb 14;:

Authors: Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, Suzaki H, Fujieda S, Masuyama K, Japanese Society of Allergology

Abstract
Like asthma and atopic dermatitis, allergic rhinitis is an allergic disease, but of the three, it is the only type I allergic disease. Allergic rhinitis includes pollinosis, which is intractable and reduces quality of life (QOL) when it becomes severe. A guideline is needed to understand allergic rhinitis and to use this knowledge to develop a treatment plan. In Japan, the first guideline was prepared after a symposium held by the Japanese Society of Allergology in 1993. The current 8th edition was published in 2016, and is widely used today. To incorporate evidence based medicine (EBM) introduced from abroad, the most recent collection of evidence/literature was supplemented to the Practical Guideline for the Management of Allergic Rhinitis in Japan 2016. The revised guideline includes assessment of diagnosis/treatment and prescriptions for children and pregnant women, for broad clinical applications. An evidence-based step-by-step strategy for treatment is also described. In addition, the QOL concept and cost benefit analyses are also addressed. Along with Allergic Rhinitis and its Impact of Asthma (ARIA), this guideline is widely used for various clinical purposes, such as measures for patients with sinusitis, childhood allergic rhinitis, oral allergy syndrome, and anaphylaxis and for pregnant women. A Q&A section regarding allergic rhinitis in Japan was added to the end of this guideline.

PMID: 28214137 [PubMed - as supplied by publisher]

http://ift.tt/2lXbRSV

Re: Should we consider devolution of "head and neck" surgery from the specialties of oral and maxillofacial surgery; ear, nose and throat surgery; and plastic surgery?

Re: Should we consider devolution of "head and neck" surgery from the specialties of oral and maxillofacial surgery; ear, nose and throat surgery; and plastic surgery?

Br J Oral Maxillofac Surg. 2017 Feb 14;:

Authors: Elledge R, Walton G, Sandhu R, Prasad S, Howe D

PMID: 28214026 [PubMed - as supplied by publisher]

http://ift.tt/2mbrPVF

Long-term outcomes of endolymphatic sac shunting with local steroids for Meniere's disease.

Long-term outcomes of endolymphatic sac shunting with local steroids for Meniere's disease.

Am J Otolaryngol. 2017 Jan 20;:

Authors: Wick CC, Manzoor NF, McKenna C, Semaan MT, Megerian CA

PMID: 28214024 [PubMed - as supplied by publisher]

http://ift.tt/2lX6KCi

Αρχειοθήκη ιστολογίου

! # Ola via Alexandros G.Sfakianakis on Inoreader

Η λίστα ιστολογίων μου

Κυριακή 19 Φεβρουαρίου 2017

Abstract

Introduction

Case Report

Discussion

Abstract

Background

Methods

Results

Conclusions

Αρχειοθήκη ιστολογίου