The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculation

alexandrossfakianakis shared this article with you from Inoreader The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculation Via Head & Neck Abstract Background Late side effects of radiotherapy in patients with head and neck cancer (HNCPs) result in decreased tissue vascularity, a compromised healing capacity and spontaneous breakdown of tissue. The aim of this study was to examine the in vivo effect of hyperbaric oxygen therapy (HBOT) on the microcirculation in irradiated oral tissue. Methods Using a handheld microscope, the effect of HBOT on oral mucosal microcirculation parameters was measured in 34 previously irradiated HNCPs prior to HBOT and at 4 weeks and 6 months posttreatment. Results A significant increase in mean buccal vessel density and decrease in buccal vessel diameter was found 6 months after HBOT compared to baseline, 22 ± 11 versus 25 ± 7 cpll/mm2 (p < 0.05) and 20 ± 4 versus 16 ± 5 μm (p < 0.05), respectively. Conclusion Our results indicate that oral microcirculation histopathology associated with irradiation is able to respond to HBOT by redirecting oral microcirculation parameters towards values consistent with healthy tissue. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Postoperative consequences of cancer cachexia after head and neck free flap reconstruction

alexandrossfakianakis shared this article with you from Inoreader Postoperative consequences of cancer cachexia after head and neck free flap reconstruction Via Head & Neck Abstract Background Cachexia is detrimental for patients with head and neck cancer (HNC). However, postoperative consequences of HNC cachexia remain unknown. Methods A 2014–2019 retrospective review was performed of adults undergoing aerodigestive HNC resection with free tissue reconstruction. Propensity score matching using inverse probability of treatment weighting (IPTW) of cachectic and control groups was employed to adjust for covariate imbalances followed by binary logistic regression on postoperative outcomes. Results Out of 252 total patients, 135 (53.6%) had cancer cachexia. The cohort was predominantly white (94.4%) males (65.1%) aged 61.5 ± 11.5 years with stage III–IV (84.1%) malignancy of the oral cavity (66.3%). After matching cohort pre- and intra-operative covariates using IPTW, cancer cachexia remained a strong, significant predictor of serious National Surgical Quality Improvement Program (NSQIP) complications (OR [95%CI] = 3.84 [1.80–8.21]) and major Clavien-Dindo complications (OR [95%CI] = 3.00 [1.18–7.60]). Conclusions Cancer cachexia is associated with worse HNC free flap reconstruction outcomes. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Efficacy of the systemic co-administration of vitamin D3 in reversing the inhibitory effects of sodium alendronate on orthodontic tooth movement: A preliminary experimental animal study

alexandrossfakianakis shared this article with you from Inoreader Efficacy of the systemic co-administration of vitamin D3 in reversing the inhibitory effects of sodium alendronate on orthodontic tooth movement: A preliminary experimental animal study Via American Journal of Orthodontics and Dentofacial Orthopedics Publication date: Available online 29 April 2022 Source: American Journal of Orthodontics and Dentofacial Orthopedics Author(s): Mehrnaz Moradinejad, Marzie Yazdi, Seyed Ali Mard, Seyed Mohammad Razavi, Milad Shamohammadi, Fatemeh Shahsanaei, Vahid Rakhshan View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Verapamil down‐regulates iron uptake and up‐regulates divalent metal transporter 1 expression in H9C2 cardiomyocytes

alexandrossfakianakis shared this article with you from Inoreader Verapamil down‐regulates iron uptake and up‐regulates divalent metal transporter 1 expression in H9C2 cardiomyocytes Via Fundamental & Clinical Pharmacology Abstract Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes. However, LVDCC (L-type voltage-dependent Ca2+ channel) blockers were recently demonstrated to significantly reduce NTBI uptake by cardiomyocytes, implying that LVDCC plays a dominant role in NTBI uptake by cardiomyocytes under iron-overloaded conditions. These findings led us to hypothesize that the LVDCC blocker-induced reduction in NTBI uptake might result not only from the inhibition of LVDCC-mediated NTBI uptake but also from the suppression of DMT1-mediated NTBI uptake. We therefore investigated the effects of the LVDCC blocker verapamil on NTBI uptake as well as DMT1 expression in H9C2 cells by the measurement of radio-labeled 55Fe(II), RT-PCR and western blot analysis. We demonstrated that verapamil induced a significant reduction in NTBI uptake by H9C2 cells, but also unexpectedly a remarkable increase rather than decrease in the expression of DMT1 mRNA and protein in H9C2 cells. Our findings imply that the verapamil-induced reduction in NTBI uptake by H9C2 cells is not associated with DMT1, and also indicate that verapamil stimulates rather than inhibits DMT1 expression and DMT1–mediated iron uptake by heart cells. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Level Ib CTV delineation in nasopharyngeal carcinoma based on lymph node distribution and topographic anatomy

alexandrossfakianakis shared this article with you from Inoreader Level Ib CTV delineation in nasopharyngeal carcinoma based on lymph node distribution and topographic anatomy Via radiotheraphy Publication date: Available online 29 April 2022 Source: Radiotherapy and Oncology Author(s): Yue Zhao, Xiongfei Liao, Yiling Wang, Wanying Lan, Jing Ren, Ningjing Yang, Churong Li, Jingyi Lang, Shichuan Zhang View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

HIV is associated with elevated FibroScan-AST (FAST) score

alexandrossfakianakis shared this article with you from Inoreader HIV is associated with elevated FibroScan-AST (FAST) score Via Clinical Infectious Diseases Advance Access Abstract Background & Aims Whether HIV infection is associated with the development of nonalcoholic steatohepatitis (NASH) remains unclear. The FibroScan-AST (FAST) score was developed to identify patients who have histologic NASH with high nonalcoholic fatty liver disease activity score (NAS≥4) and significant liver fibrosis (≥F2), which has been associated with higher risk of end-stage liver disease. We examined whether HIV infection is associated with elevated FAST score in a large United States (US) cohort. Approach Vibration controlled transient elastography was performed in 1309 women without history of chronic viral hepatitis enrolled from 10 US sites: 928 women living with HIV (WLWH) and 381 women living without HIV (WLWOH). We used multivariable logistic regression to evaluate associations of HIV, demographic, lifestyle, and metabolic factors with an elevated (>0.35) FAST score. Results Median age of WLWH and WLWOH was 51 years and 48 years, respectively. Most (90%) WLWH were on antiretroviral therapy and 72% had undetectable HIV RNA. Prevalence of elevated FAST score was higher among WLWH compared to WLWOH, 6.3% vs 1.8% (p=0.001). On multivariable analysis, HIV infection was associated with 3.7-fold higher odds of elevated FAST score (p=0.002) and greater waist circumference (per 10 cm) was associated with 1.7-fold higher odds (p<0.001). In analysis limited to WLWH, undetectable HIV RNA and current protease inhibitor use were independently associated with lower odds of elevated FAST score. Conclusions Our findings suggest that HIV is an independent risk factor for NASH with significant activity and fibrosis. Studies validating FAST score in persons living with HIV are warranted. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Relative Vaccine Effectiveness of a SARS-CoV-2 mRNA Vaccine Booster Dose Against the Omicron Variant

alexandrossfakianakis shared this article with you from Inoreader Relative Vaccine Effectiveness of a SARS-CoV-2 mRNA Vaccine Booster Dose Against the Omicron Variant Via Clinical Infectious Diseases Advance Access Abstract Background The current SARS-CoV-2 vaccines may be less effective against the Omicron variant. With recent resurgence of SARS-CoV-2 cases, the role of booster doses of the vaccine needs to be highlighted. Methods Using a retrospective cohort study design emulating a target trial, we determined the relative effectiveness of a homologous booster dose of a SARS-CoV-2 mRNA vaccine compared with primary series alone in preventing infection, hospitalization, a nd intensive care unit (ICU) admission, and death in the Department of Veterans Affairs healthcare system in the US. Among infection-free survivors who received two doses of an mRNA vaccine prior to April 30, 2021, we identified those who received a booster between September 22 and December 25, 2021 and 1:1 matched individuals who did not receive a booster. Results Among 2,384,272 previously uninfected persons with two doses of an mRNA vaccine by April 30, 2021, we identified 462,950 booster recipients between September 22 and December 25, 2021 who were matched 1:1 with non-booster recipients. RVE (95% CI) was 19% (17-22%) for confirmed infection, 52% (46-57%) for hospitalization, and 83% (65-92%) for ICU admission or death. Recipients of the mRNA-1273 vaccine had a lower cumulative incidence of infections and hospitalizations compared with BNT-162b2 vaccine (log-rank p-value <0.001 for both comparisons). Conclusion While the RVE of SARS-CoV-2 mRNA booster vacci ne dose in preventing infection against the Omicron variant is low, the RVE is substantial in preventing hospitalization and high in preventing the most severe/critical disease. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Gratitude, relatedness needs satisfaction, and negative psychological outcomes during the COVID‐19 pandemic: A short‐term longitudinal study

alexandrossfakianakis shared this article with you from Inoreader Gratitude, relatedness needs satisfaction, and negative psychological outcomes during the COVID‐19 pandemic: A short‐term longitudinal study Via Journal of Clinical Psychology Abstract Objectives Although gratitude relates to coronavirus disease 2019 (COVID-19) well-being outcomes in the United States, more evidence is needed to understand how this psychological strength reciprocally relates to mental health during this pandemic. This study examines the association of gratitude with stress, anxiety, and depression among undergraduate students in the United States via a longitudinal design. Methods An online survey was administered to 643 undergraduate students in a public university located in the southeastern region of the United States. There was a 1-month interval between the first and second waves of data collection. Results Cross-lagged panel structural equation modeling showed that whereas gratitude positively predicted subsequent relatedness needs satisfaction, it negatively predicted later stress, anxiety, and depression. Relatedness needs satisfaction was reciprocally linked to subsequent gratitude. Conclusion Results suggest that gratitude might serve as a protective psychological resource against the detrimental mental health impacts of the COVID-19 pandemic. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Investigating the efficacy of attentional bias modification on individuals with spider phobia through the emotional attention network test

alexandrossfakianakis shared this article with you from Inoreader Investigating the efficacy of attentional bias modification on individuals with spider phobia through the emotional attention network test Via Journal of Clinical Psychology Abstract Objectives This study aimed to investigate the attention network function of spider phobics before and after attentional bias modification (ABM) through conduction of an emotional attention network test (eANT). Methods Scores from an eANT, an approach–avoidance task, and various scales were used to examine the training effect of a single ABM session among participants (30 individuals with spider phobia and 30 controls). Results At baseline, alertness scores in response to spider images were higher in the phobia group than in the control group (x̄ = 51.81 vs. 30.35 ms). After ABM, this score decreased in the phobia group, indicating their lower susceptibility to distraction by images of spiders. However, ABM training did not considerably alleviate their fear of and avoidance behavior toward spiders. Conclusion This study elucidates the (1) vigilance–avoidance pattern among individuals with spider phobia when encountering spider-related stimuli and (2) change in underlying attentional mechanisms after ABM training. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts

alexandrossfakianakis shared this article with you from Inoreader PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts Via Blood Cancer Journal - Issue - nature.com science feeds View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation

alexandrossfakianakis shared this article with you from Inoreader Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation Via International Journal of Radiation Biology: Table of Contents: Taylor and Francis . View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clinical evaluation of the GSD NovaPrime® SARS-CoV-2 RTq-PCR assay

alexandrossfakianakis shared this article with you from Inoreader Clinical evaluation of the GSD NovaPrime® SARS-CoV-2 RTq-PCR assay Via ScienceDirect Publication: Diagnostic Microbiology and Infectious Disease Publication date: Available online 3 May 2022 Source: Diagnostic Microbiology and Infectious Disease Author(s): Marie Tré-Hardy, Sébastien Piteüs, Ingrid Beukinga, Laurent Blairon View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

COVID-19: Τι είναι το πρωτεϊνικό εμβόλιο της Novavax

alexandrossfakianakis shared this article with you from Inoreader COVID-19: Τι είναι το πρωτεϊνικό εμβόλιο της Novavax Via HealthyLiving.gr Ιατροί της Θεραπευτικής Κλινικής της Ιατρικής Σχολής του ΕΚΠΑ συνοψίζουν τα στοιχεία που ξέρουμε για το πρωτεϊνικό εμβόλιο Novavax (Nuvaxovid) που έγινε πρόσφατα διαθέσιμο στη χώρα μας. Τρόπος παρασκευής: Το NVX-CoV2373 είναι ένα εμβόλιο υπομονάδας που κατασκευάζεται από μια σταθεροποιημένη μορφή της πρωτεϊνικής ακίδας S του SARS-CoV-2 με τη χρήση τεχνολογίας νανοσωματιδίων. Τα συγκεκριμένα πρωτεϊνικά αντιγόνα που εμπεριέχονται στο εμβόλιο δεν μπορούν να αναπαραχθούν ή να προκαλέσουν COVID-19. Το εμβόλιο περιέχει επίσης ένα ανοσοενισχυτικό ώστε να ενισχύσει την ανταπόκριση του ανοσοποιητικού συστήματος και τη δημιουργία ανοσιακής μνήμης. Μια εφάπαξ δόση εμβολίου περιέχει 5 μικρογραμμάρια (mcg) πρωτεΐνης και 50 mcg ανοσοενισχυτικού. Τρόπος χορήγησης και αποθήκευσης: Το NVX-CoV2373 χορηγείται με ένεση σε υγρή μορφή και μπορεί να αποθηκευτεί και να διανεμηθεί σε συνήθεις θερμοκρασίες ψυγείου (1,7°C έως 7,5°C), χωρίς να απαιτείται βαθιά κατάψυξη. Το εμβόλιο χορηγείται ως δύο ενδομυϊκές ενέσεις σε απόσταση 21 ημερών (3 εβδομάδες). Οι ανοσοκατεσταλμένοι ασθενείς μπορεί να έχουν μειωμένη ανοσολογική ανταπόκριση στον εμβολιασμό και γι΄ αυτό είναι υποψήφιοι για χορήγηση αναμνηστικής δόσης. Το εμβόλιο Novavax μπορεί να συνδυαστεί με άλλα εγκεκριμένα εμβόλια, αν και η διαδικασία συλλογής δεδομένων για την αποτελεσματικότητα αυτής της στρατηγικής είναι σε εξέλιξη. Προκαταρκτικά δεδομένα έχουν δείξει ότι η χορήγηση του εμβολίου της Novavax μετά από μια δόση του εμβολίου της AstraZeneca οδηγεί στην παραγωγή υψηλών τίτλων εξουδετερωτικών αντισωμάτων και ιδιαίτερα ισχυρής Τ-ανοσιακής απόκρισης, η οποία υπερτερεί του συνδυασμού δύο δόσεων του εμβολίου της AstraZeneca. Αυτό είναι πολύ σημαντικό καθώς και τα δύο εμβόλια διατηρούνται στη ψύξη και όχι στην κατάψυξη και επομένως είναι ευκολότερη η ευρεία διάθεσή τους χωρίς την ανάγκη ειδικών υποδομών. Κλινική αποτελεσματικότητα: Τα αποτελέσματα κλινικής μελέτης φάσης 3 PREVENT-19 στην οποία συμμετείχαν 29.960 ενήλικες εθελοντές άνω των 18 ετών στις Ηνωμένες Πολιτείες και το Μεξικό έδειξαν ότι το ερευνητικό εμβόλιο NVX-CoV2373 της Novavax είχε 90,4% αποτελεσματικότητα ως προς την πρόληψη της συμπτωματικής νόσου COVID-19. Ακόμα πιο σημαντικό είναι ότι το νέο εμβόλιο έδειξε 100% προστασία από COVID-19 μέτριας και σοβαρής βαρύτητας. Σε άτομα με υψηλό κίνδυνο εμφάνισης επιπλοκών από τη COVID-19 (άτομα 65 ετών και άνω, άτομα κάτω των 65 ετών με ορισμέ� �ες συννοσηρότητες ή με πιθανή τακτική έκθεση στον SARS-CoV-2), το εμβόλιο έδειξε 91% αποτελεσματικότητα ως προς την πρόληψη της συμπτωματικής νόσου COVID-19. Δεν υπάρχουν διαθέσιμα σαφή στοιχεία για την αποτελεσματικότητα του εμβολίου ως προς το δυναμικό μετάδοσης του SARS-CoV-2. Οι συμμετέχοντες έλαβαν τυχαία με αναλογία 2:1 είτε το νέο εμβόλιο είτε το εικονικό φάρμακο σε δύο δόσεις με απόσταση 21 ημερών. Η κλινική δοκιμή ήταν διπλά τυφλή, δηλαδή ούτε οι ερευνητές ούτε οι συμμετέχοντες ήξεραν ποιος έλαβε το υποψήφιο εμβόλιο. Η μελέτη PREVENT-19 σχεδιάστηκε για να αξιολογήσει εάν το NVX-CoV2373 μπορεί να αποτρέψει τη συμπτωματική νόσο COVID-19 επτά ή περισσότερες ημέρες μετά τη δεύτερη δόση σε σχέση με το εικονικό φάρμακο. Κατά την περίοδο πραγματοποίησης της μελέτης τα κυρίαρχα στελέχη σε αυτές τις χώρες ήταν το Άλφα, το Βήτα και το Δέλτα. Τα δεδομένα για την ακριβή αποτελεσματικότητα έναντι της Όμικρον συλλέγονται τώρα σε πραγματικό χρόνο. Κλινικές μελέτες βρίσκονται σε εξέλιξη για να συλλεχθούν δεδομένα ασφάλειας και ανοσογονικότητας για άτομα ηλικίας κάτω των 18 ετών. Ασφάλεια: Τα δεδομένα ασφαλείας δείχνουν ότι το εμβόλιο Novavax είναι γενικά καλά ανεκτό. Ο ήπιος έως μέτριος πόνος και η ευαισθησία στο σημείο της ένεσης ήταν τα πιο κοινά εντοπισμένα συμπτώματα. Η κόπωση, ο πονοκέφαλος και ο μυϊκός πόνος που κράτησε λιγότερο από δύο ημέρες ήταν τα πιο συνηθισμένα συστηματικά συμπτώματα που εμφάνισαν οι εμβολιασθέντες. Εγκυμοσύνη και Θηλασμός: Σύμφωνα με τον Παγκόσμιο Οργανισμό Υγείας, δεν υπάρχουν διαθέσιμα δεδομένα σχετικά με την ασφάλεια και την αποτελεσματικότητα της χρήσης του εμβολίου Novavax (NVX-CoV2373) σε εγκύους. Ωστόσο, με βάση προηγούμενα στοιχεία από άλλα εμβόλια που βασίζονται σε πρωτεΐνες κατά τη διάρκεια της εγκυμοσύνης, η αποτελεσματικότητα αναμένεται να είναι συγκρίσιμη με τις μη έγκυες γυναίκες παρόμοιας ηλικίας. Ο Παγκόσμιος Οργανισμός Υγείας συστήνει τη χορήγηση του εμβολίου COVID-19 σε εγκύους όταν τα οφέλη του εμβ ολιασμού υπερτερούν των πιθανών κινδύνων. Καθώς το εμβόλιο Novavax (NVX-CoV2373) δεν περιέχει ζωντανό ιό, είναι βιολογικά και κλινικά απίθανο να ενέχει κίνδυνο για το παιδί που θηλάζει. Αντενδείξεις: Άτομα με ιστορικό αναφυλαξίας σε οποιοδήποτε συστατικό του εμβολίου δεν συστήνεται να το λάβουν. Τα άτομα με ενεργό λοίμωξη COVID-19 δε θα πρέπει να εμβολιάζονται μέχρι να αναρρώσουν και να έχουν ολοκληρώσει την περίοδο της καραντίνας. The post COVID-19: Τι είναι το πρωτεϊνικό εμβόλιο της Novavax appeared first on HealthyLiving.gr. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.