Δευτέρα 16 Απριλίου 2018
Simultaneously elevated FeNO and blood eosinophils relate to asthma morbidity in asthmatics from NHANES 2007‐12
Clinical &Experimental Allergy, EarlyView.
https://ift.tt/2H4AlEM
Erythrodermic psoriasis and secukinumab: Our clinical experience
Dermatologic Therapy, EarlyView.
https://ift.tt/2HxW874
Erythrodermic psoriasis and secukinumab: Our clinical experience
Dermatologic Therapy, EarlyView.
https://ift.tt/2HxW874
A carbonate-free, sulfone-based electrolyte for high-voltage Li-ion batteries
Publication date: Available online 16 April 2018
Source:Materials Today
Author(s): Judith Alvarado, Marshall A. Schroeder, Minghao Zhang, Oleg Borodin, Eric Gobrogge, Marco Olguin, Michael S. Ding, Mallory Gobet, Steve Greenbaum, Ying Shirley Meng, Kang Xu
Practical implementation of next-generation Li-ion battery chemistries is to a large extent obstructed by the absence of an electrolyte that is capable of simultaneously supporting reversible electrochemical reactions at two extreme electrochemical potentials—above 4.5 V at the positive electrode and near 0 V vs. Li at the negative electrode. Electrolytes based on carbonate esters have been reliable in satisfying state-of-the-art Li-ion battery (LIB) chemistries below <4.2 V; however, it is the intrinsic thermodynamic tendency of these carbonates to decompose at potentials well below the thermodynamic threshold required for reversible reactions of high-voltage systems (>4.4 V), releasing CO2. In this work, we explore a carbonate-free electrolyte system based on a single sulfone solvent, in which a newly discovered synergy between solvent and salt simultaneously addresses the interfacial requirements of both graphitic anode and high-voltage cathode (LiNi0.5Mn1.5O4 (LNMO)). Experimental measurements, quantum chemistry (QC) calculations, and molecular dynamics simulations reveal the system's fast ion conduction, stability over a wide temperature range, and non-flammability. At the anode, a LiF-rich interphase generated by early-onset reduction of the salt anion effectively suppresses solvent co-intercalation and subsequent graphite exfoliation, enabling unprecedented and highly reversible graphite cycling in a pure sulfone system. Under oxidative conditions, QC calculations predict that high salt concentration promotes complex/aggregate formation which slow the decomposition of sulfolane and leads to polymerizable rather than gaseous products—a fundamental improvement over carbonate solvents. These predictions are corroborated by X-ray photoelectron spectroscopy (XPS), cryogenic-transmission electron microscopy (TEM), and electron energy loss spectroscopy (EELS) experiments, which revealed the presence of a thin, conformal, sulfur-based cathode electrolyte interphase (CEI). Together, the functional interphases (SEI/CEI) generated by this electrolyte system supported long term operation of a high-voltage (4.85 V) LNMO/graphite full cell, which retained ∼70% of its original first-cycle discharge capacity after the 1000th cycle. Based on these results, this new carbonate-free electrolyte system, supported by the mechanistic understanding of its behavior, presents a promising new direction toward unlocking the potential of next generation Li-ion battery electrodes.
Graphical abstract
https://ift.tt/2EQNaN9
Recent progresses on physics and applications of vanadium dioxide
Publication date: Available online 16 April 2018
Source:Materials Today
Author(s): Kai Liu, Sangwook Lee, Shan Yang, Olivier Delaire, Junqiao Wu
As a strongly correlated electron material, vanadium dioxide (VO2) has been a focus of research since its discovery in 1959, owing to its well-known metal–insulator transition coupled with a structural phase transition. Recent years have witnessed both exciting discoveries in our understanding of the physics of VO2 and developments in new applications of VO2-related materials. In this article, we review some of these recent progresses on the phase transition mechanism and dynamics, phase diagrams, and imperfection effects, as well as growth and applications of VO2. Our review not only offers a summary of the properties and applications of VO2, but also provides insights into future research of this material by highlighting some of the challenges and opportunities.
Graphical abstract
https://ift.tt/2qAu8X4
Composite bending-dominated hollow nanolattices: A stiff, cyclable mechanical metamaterial
Publication date: Available online 16 April 2018
Source:Materials Today
Author(s): Biwei Deng, Rong Xu, Kejie Zhao, Yongfeng Lu, Sabyasachi Ganguli, Gary J. Cheng
Manufacturing ultralight and mechanical reliable materials has been a long-time challenge. Ceramic-based mechanical metamaterials provide significant opportunities to reverse their brittle nature and unstable mechanical properties and have great potential as strong, ultralight, and ultrastiff materials. However, the failure of ceramics nanolattice and degradation of strength/modulus with decreasing density are caused by buckling of the struts and failure of the nodes within the nanolattices, especially during cyclic loading. Here, we explore a new class of 3D ceramic-based metamaterials with a high strength–density ratio, stiffness, recoverability, cyclability, and optimal scaling factor. Deformation mode of the fabricated nanolattices has been engineered through the unique material design and architecture tailoring. Bending-dominated hollow nanolattice (B-H-Lattice) structure is employed to take advantages of its flexibility, while a few nanometers of carbonized mussel-inspired bio-polymer (C-PDA) is coherently deposited on ceramics' nanolayer to enable non-buckling struts and bendable nodes during deformation, resulting in reliable mechanical properties and outperforming the current bending-dominated lattices (B-Lattices) and carbon-based cellulose materials. Meanwhile, the structure has comparable stiffness to stretching-dominated lattices (S-Lattices) while with better cyclability and reliability. The B-H-Lattices exhibit high specific stiffness (>106 Pa·kg−1·m−3), low-density (∼30 kg/m3), buckling-free recovery at 55% strain, and stable cyclic loading behavior under up to 15% strain. As one of the B-Lattices, the modulus scaling factor reaches 1.27, which is lowest among current B-Lattices. This study suggests that non-buckling behavior and reliable nodes are the key factors that contribute to the outstanding mechanical performance of nanolattice materials. A new concept of engineering the internal deformation behavior of mechanical metamaterial is provided to optimize their mechanical properties in real service conditions.
Graphical abstract
https://ift.tt/2vjDefk
To Study the Role of FNAC in Pre-operative Diagnostic Work Up and Management in Parotid Tumours
Abstract
Parotid gland is an important major salivary gland connected to the oral cavity. Salivary gland tumours are infrequent around less than 3% of head and neck tumours. Parotid gland is the most common site for the occurrence of salivary tumors. They are heterogeneous group of neoplasm characterized by the varying histological features and clinical behaviour. In our study we have examined the role of FNAC for preoperative diagnostic and management. We have concluded that Fine needle aspiration cytology is advocated routinely to know the type and nature of the tumour as an important pre-operatively diagnostic work up. It helps in preoperative identification of type of tumour neoplastic or benign, preoperative counselling of patient, planning of management of tumour, and preparing the patient and the surgical team for the more extensive procedure generally required for a high grade malignancy.
https://ift.tt/2qDPL82
Newborn Hearing Screening: Time to Act!
Abstract
The present study was carried out with the aim of assessing the outcomes of otoacoustic hearing screening in newborns coupled with the three stage protocol. It was a hospital based observational study which was conducted over a time period of twelve months at a tertiary care institute to screen 2000 live neonates for congenital hearing impairment using OAE, followed up by tympanometry and BERA, if required. 2000 neonates were screened for hearing impairment. 406 were in high risk group and the rest in non-high risk group. Seven neonates had absent V wave on BERA. Five of them were high risk babies and the rest two were non-high risk ones. In order to ensure that early detection and effective intervention are possible for all neonates with hearing impairment, UNHS should be performed. Three stage UNHS protocol using OAE and BERA showed that the implementation of UNHS for congenital childhood hearing loss for all neonates would be beneficial.
https://ift.tt/2H4bErX
Primary cutaneous ganglioneuroma: anatomoclinical study of 4 cases with focus on Merkel cells
Journal of Cutaneous Pathology, EarlyView.
https://ift.tt/2vjw8rc
Invasive Listeriosis of Intracardiac Device
Introduction. Listeria monocytogenes is a food-borne pathogen which can cause invasive infection in immunocompromised adults. Listeria has been known to cause infections during pregnancy and in older adults. Listeria endocarditis is a rare condition. A case of listeria-related intracardiac device infection is reported below. Case Report. A 74-year-old male with a past medical history of coronary artery disease, congestive cardiac failure, permanent atrial fibrillation status after nodal ablation, and placement of a biventricular pacemaker presented to the hospital with complaints of generalized fatigue. He was found to have listeria bacteremia, and transthoracic echocardiogram (TTE) showed pacemaker lead vegetation. The patient was treated with 6 weeks of vancomycin followed by oral suppression with amoxicillin. Discussion. Listeria can affect native valves, prosthetic valves, or nonvalvular intracardiac devices. The mean age of prosthetic valve endocarditis has been reported to be 67 years with male-to-female ratio 1.7 : 1 and mitral-to-aortic valve ratio 1.3 : 1. There have been case reports of listeria prosthetic valve endocarditis; however, there is paucity of literature on listeria-related pacemaker lead infection. Treatment is mostly a combination of penicillin and aminoglycosides for 4–6 weeks. Surgical removal of the infected device is preferred. Invasive listeriosis is a rare but fatal entity which should be identified and treated promptly to ensure a good outcome.
https://ift.tt/2ETj5fM
Versatile effects of magnesium hydroxide nanoparticles in PLGA scaffold–mediated chondrogenesis
Publication date: Available online 16 April 2018
Source:Acta Biomaterialia
Author(s): Kwang-Sook Park, Byoung-Ju Kim, Eugene Lih, Wooram Park, Soo-Hong Lee, Yoon Ki Joung, Dong Keun Han
Artificial scaffolds made up of various synthetic biodegradable polymers have been reported to have many advantages including cheap manufacturing, easy scale up, high mechanical strength, convenient manipulation, and molding into an unlimited variety of shapes. However, the synthetic biodegradable polymers still have the insufficiency for cartilage regeneration owing to their acidic degradation products. To reduce acidification by degradation of synthetic polymers, we incorporated magnesium hydroxide (MH) nanoparticles into porous polymer scaffold not only to effectively neutralize the acidic hydrolysate but also to minimize the structural disturbance of scaffolds. The neutralization effect of poly(D,L-lactic-co-glycolic acid; PLGA)/MH scaffold was confirmed with the maintenance of neutral pH, contrary to a PLGA scaffold with low pH. Further, the scaffolds were applied to evaluate the chondrogenic differentiation of the human bone marrow mesenchymal stem cells. In in vitro study, the PLGA/MH scaffold enhanced the chondrogenesis markers and reduced the calcification, compared to the PLGA scaffold. Additionally, the PLGA/MH scaffold reduced the release of inflammatory cytokines, compared to the PLGA scaffold, as the cell death decreased. Moreover, the addition of MH reduced necrotic cell death at the early stage of chondrogenic differentiation. Further, the necrotic cell death by the PLGA scaffold was mediated by cleavage of caspase-1, the so-called interleukin 1-converting enzyme, and MH alleviated it as well as nuclear factor kappa B expression. Furthermore, the PLGA/MH scaffold highly supported chondrogenic healing of rat osteochondral defect sites in in vivo study. Therefore, it was suggested that a synthetic polymer scaffold containing MH could be a novel healing tool to support cartilage regeneration and further treatment of orthopedic patients.Statement of SignificanceSynthetic polymer scaffolds have been widely utilized for tissue regeneration. However, they have limitations of acidic products by degradation. This paper demonstrated a novel type of synthetic polymer scaffold with pH-neutralizing ceramic nanoparticles, magnesium hydroxide, for cartilage regeneration. It showed pH-neutralization during polymer degradation and significant enhancement of chondrogenic differentiation of mesenchymal stem cells. It reduced not only chondrogenic calcification but also release of proinflammatory cytokines. Moreover, it has an inhibitive effect on necrotic cell death, particularly caspase-1-mediated necrotic cell death (pyroptosis). In in vivo study, it showed higher healing of damaged cartilage in rat osteochondral defect model. We expected that this novel type of scaffold can be effectively applied to support cartilage regeneration and further treatment of orthopedic patients.
Graphical abstract
https://ift.tt/2qBFBFt
Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair
Publication date: Available online 16 April 2018
Source:Acta Biomaterialia
Author(s): Biranche Tandon, Jonny J. Blaker, Sarah H. Cartmell
The process of bone repair and regeneration requires multiple physiological cues including biochemical, electrical and mechanical - that act together to ensure functional recovery. Myriad materials have been explored as bioactive scaffolds to deliver these cues locally to the damage site, amongst these piezoelectric materials have demonstrated significant potential for tissue engineering and regeneration, especially for bone repair. Piezoelectric materials have been widely explored for power generation and harvesting, structural health monitoring, and use in biomedical devices. They have the ability to deform with physiological movements and consequently deliver electrical stimulation to cells or damaged tissue without the need of an external power source. Bone itself is piezoelectric and the charges/potentials it generates in response to mechanical activity are capable of enhancing bone growth. Piezoelectric materials are capable of stimulating the physiological electrical microenvironment, and can play a vital role to stimulate regeneration and repair.This review gives an overview of the association of piezoelectric effect with bone repair, and focuses on state-of-the-art piezoelectric materials (polymers, ceramics and their composites), the fabrication routes to produce piezoelectric scaffolds, and their application in bone repair. Important characteristics of these materials from the perspective of bone tissue engineering are highlighted. Promising upcoming strategies and new piezoelectric materials for this application are highlighted.Statement of significanceElectrical stimulation/electrical microenvironment are known effect the process of bone regeneration by altering the cellular response and are crucial in maintaining tissue functionality. Piezoelectric materials, owing to their capability of generating charges/potentials in response to mechanical deformations, have displayed great potential for fabricating smart stimulatory scaffolds for bone tissue engineering. The growing interest of the scientific community and compelling results of the published research articles has been the motivation of this review article. This article summarizes the significant progress in the field with a focus on the fabrication aspects of piezoelectric materials. The review of both material and cellular aspects on this topic ensures that this paper appeals to both material scientists and tissue engineers.
Graphical abstract
https://ift.tt/2EPRegw
Electrospun silk fibroin fibers for storage and controlled release of human platelet lysate.
Publication date: Available online 17 April 2018
Source:Acta Biomaterialia
Author(s): Cataldo Pignatelli, Giovanni Perotto, Marta Nardini, Ranieri Cancedda, Maddalena Mastrogiacomo, Athanassia Athanassiou
Human platelet lysate (hPL) is a pool of growth factors and cytokines able to induce regeneration of different tissues. Despite its good potentiality as therapeutic tool for regenerative medicine applications, hPL has been only moderately exploited in this field. A more widespread adoption has been limited because of its rapid degradation at room temperature that decreases its functionality. Another limiting factor for its extensive use is the difficulty of handling the hPL gels. In this work, silk fibroin-based patches were developed to address several points: improving the handling of hPL, enabling their delivery in a controlled manner and facilitating their storage by creating a device ready to use with expanded shelf life. Patches of fibroin loaded with hPL were synthesized by electrospinning to take advantage of the fibrous morphology. The release kinetics of the material was characterized and tuned through the control of fibroin crystallinity. Cell viability assays, performed with primary human dermal fibroblasts, demonstrated that fibroin is able to preserve the hPL biological activity and prolong its shelf-life. The strategy of storing and preserving small active molecules within a naturally-derived, protein-based fibrous scaffold was successfully implemented, leading to the design of a biocompatible device, which can potentially simplify the storage and the application of the hPL on a human patient, undergoing medical procedures such as surgery and wound care.Statement of significanceHuman platelets lysate (hPL) is a mixture of growth factors and cytokines able to induce the regeneration of damaged tissues. In this study, we aim at enclosing hPL in a silk fibroin electrospun matrix to expand its utilization. Silk fibroin showed the ability to preserve the hPL activity at temperature up to 60 °C and the manipulation of fibroin's crystallinity provided a tool to modulate the hPL release kinetic. This entails the possibility to fabricate the hPL silk patches in advance and store them, resulting in an easy and fast accessibility and expand the use of hPL for wound healing.
Graphical abstract
https://ift.tt/2vhCZBD
High glucose forces a positive feedback loop connecting ErbB4 expression and mTOR/S6K pathway to aggravate the formation of tau hyperphosphorylation in differentiated SH-SY5Y cells
Source:Neurobiology of Aging, Volume 67
Author(s): Sheng-Dan Nie, Xin Li, Can-E. Tang, Fang-Yuan Min, Xia-Jie Shi, Liang-Yan Wu, Shan-Lei Zhou, Zi Chen, Jing Wu, Tao Song, Zhi-Jie Dai, Jiao Zheng, Jia-jia Liu, Shan Wang
High glucose (HG)-induced mammalian target of rapamycin (mTOR) overactivation acts as a signaling hub for the formation of tau hyperphosphorylation, which contributes to the development of diabetes-associated cognitive deficit. How HG induces the sustained activation of mTOR in neurons is not clearly understood. ErbB4, a member of the receptor tyrosine kinase family, plays critical roles in development and function of neural circuitry, relevant to behavioral deficits. Here, we showed HG-induced ErbB4 overexpression in differentiated SH-SY5Y cells and primary hippocampal neurons and hippocampal pyramidal neurons of streptozotocin-induced diabetic rats. Inhibition of ErbB4 signaling prevented the HG-induced activation of mTOR/S6K signaling to suppress tau hyperphosphorylation. In contrast, ErbB4 overexpression increased the activation of mTOR/S6K signaling, resulting in tau hyperphosphorylation similar to HG treatment. We also demonstrated that HG upregulated the expression of ErbB4 at a mTOR-dependent posttranscriptional level. Together, our results provide the first evidence for the presence of a positive feedback loop for the sustained activation of mTOR involving overexpressed ErbB4, leading to the formation of tau hyperphosphorylation under HG condition. Therefore, ErbB4 is a potential therapeutic target for diabetes-associated neurodegeneration.
https://ift.tt/2ESZGeL
Rezepte gestohlen? Schadensersatz droht!
Werden Rezepte und Stempel aus der Praxis gestohlen, sind Schadensersatzansprüche gegen Ärzte durchaus möglich — vorausgesetzt, sie haben ihre Sorgfaltspflicht verletzt.
https://ift.tt/2ES5ENc
Tagung Dermatologische Praxis 2018
Der Einsatz von Lasern in der ästhetischen Medizin ist vielfältig, wie jüngst auch wieder bei der Tagung Dermatologische Praxis 2018 gezeigt wurde. Die Weiterentwicklung der Methoden und die Kombination mit anderen Behandlungsformen verbessern die Ergebnisse zunehmend.
https://ift.tt/2JRRn70
Vitamin D schützt die Haut vor dem Altern, oder?
Die Literatur liefert widersprüchliche Ergebnisse zum Thema Vitamin D und Hautalterung. In-vitro-Experimente zeigen, dass Vitamin D die Haut vor dem Alter schützt, Populationsstudien demonstrieren das Gegenteil. Was stimmt?
https://ift.tt/2JQRwqZ
Gynäkomastie — Ursachen und mögliche Behandlungen
Die Gynäkomastie ist eine relativ verbreitete Veränderung der männlichen Brustdrüse. Vor einer Therapie sollten mögliche ursächliche Erkrankungen überprüft werden. Bei einer mäßiggradigen Ausprägung ist eine Volumenreduktion ohne Straffung der Umgebungshaut ausreichend, während bei ausgeprägteren Formen eine zusätzliche Straffung des überschüssigen Hautmantels erforderlich ist.
https://ift.tt/2vntFMF
Newborn Hearing Screening: Time to Act!
Abstract
The present study was carried out with the aim of assessing the outcomes of otoacoustic hearing screening in newborns coupled with the three stage protocol. It was a hospital based observational study which was conducted over a time period of twelve months at a tertiary care institute to screen 2000 live neonates for congenital hearing impairment using OAE, followed up by tympanometry and BERA, if required. 2000 neonates were screened for hearing impairment. 406 were in high risk group and the rest in non-high risk group. Seven neonates had absent V wave on BERA. Five of them were high risk babies and the rest two were non-high risk ones. In order to ensure that early detection and effective intervention are possible for all neonates with hearing impairment, UNHS should be performed. Three stage UNHS protocol using OAE and BERA showed that the implementation of UNHS for congenital childhood hearing loss for all neonates would be beneficial.
https://ift.tt/2H4bErX
Functional expansion pharyngoplasty: Technical update by unidirectional barbed sutures
Clinical Otolaryngology, EarlyView.
https://ift.tt/2J2gF0C
Validation of OMI erythemal doses with multi-sensor ground-based measurements in Thessaloniki, Greece
Source:Atmospheric Environment, Volume 183
Author(s): Melina Maria Zempila, Ilias Fountoulakis, Michael Taylor, Stelios Kazadzis, Antti Arola, Maria Elissavet Koukouli, Alkiviadis Bais, Chariklia Meleti, Dimitrios Balis
The aim of this study is to validate the Ozone Monitoring Instrument (OMI) erythemal dose rates using ground-based measurements in Thessaloniki, Greece. In the Laboratory of Atmospheric Physics of the Aristotle University of Thessaloniki, a Yankee Environmental System UVB-1 radiometer measures the erythemal dose rates every minute, and a Norsk Institutt for Luftforskning (NILU) multi-filter radiometer provides multi-filter based irradiances that were used to derive erythemal dose rates for the period 2005–2014. Both these datasets were independently validated against collocated UV irradiance spectra from a Brewer MkIII spectrophotometer. Cloud detection was performed based on measurements of the global horizontal radiation from a Kipp & Zonen pyranometer and from NILU measurements in the visible range. The satellite versus ground observation validation was performed taking into account the effect of temporal averaging, limitations related to OMI quality control criteria, cloud conditions, the solar zenith angle and atmospheric aerosol loading. Aerosol optical depth was also retrieved using a collocated CIMEL sunphotometer in order to assess its impact on the comparisons. The effect of total ozone columns satellite versus ground-based differences on the erythemal dose comparisons was also investigated. Since most of the public awareness alerts are based on UV Index (UVI) classifications, an analysis and assessment of OMI capability for retrieving UVIs was also performed.An overestimation of the OMI erythemal product by 3–6% and 4–8% with respect to ground measurements is observed when examining overpass and noontime estimates respectively. The comparisons revealed a relatively small solar zenith angle dependence, with the OMI data showing a slight dependence on aerosol load, especially at high aerosol optical depth values. A mean underestimation of 2% in OMI total ozone columns under cloud-free conditions was found to lead to an overestimation in OMI erythemal doses of 1–5%.While OMI overestimated the erythemal dose rates over the range of cloudiness conditions examined, its UVIs were found to be reliable for the purpose of characterizing the ambient UV radiation impact.
https://ift.tt/2qD9vbW
Epidemiological features of cancers of the oral cavity, oropharynx, hypopharynx and larynx cancer in Réunion Island
Publication date: Available online 16 April 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): A. Delagranda, G. Leterme, E. Chirpaz, C. Ferdynus, C. Fernandez, F. Rubin
IntroductionThis study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature.Material and methodA retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island. Demographic characteristics and data on alcohol consumption, smoking habits and HPV infection were analyzed. Standardized incidences were calculated for the worldwide population for both genders.ResultsSex ratio was 7.7 and mean age was 60 years. Cancer consisted of squamous cell carcinoma in 99.1% of patients. Three hundred and forty over 375 patients (81.25%) showed alcohol abuse; 309/359 (86.1%) were smokers; 31/184 (16%) had HPV infection. On the International Agency for Research on Cancer (IARC) anatomic classification, the incidence of "other pharynx" locations was 9.3/100,000 for men and 0.7/100,000 for women, and incidence of "larynx" locations was 6.4/100,000 for men and 0.4/100,000 for women.ConclusionRéunion Island features some particularities in terms of incidence: women are less than half as likely as in Metropolitan France to develop any type of cancer, whereas incidence in males is among highest in France. The presentation of results in cancer registries could be improved in line with everyday practice in head and neck surgery.
https://ift.tt/2HFJmRA
The effect of pressure and orientation on Cu-Cu3Sn interface reliability under isothermal ageing and monotonic traction via molecular dynamics investigation
Publication date: 5 July 2018
Source:Materials & Design, Volume 149
Author(s): Lihua Liang, Jicheng Zhang, Yangjian Xu, Yuanxiang Zhang, Wei Wang, Jian Yang
In this paper, the dissipative mechanisms of a Cu pad in a Ball Grid Array (BGA) packaging structure during isothermal ageing and uniaxial tension were investigated. From the result of the isothermal ageing test, a nonuniform consumption of Cu and large amount of Kirkendall voids were observed at the interface of Cu and Cu3Sn. To study the effect of pressure and orientation on this phenomenon, molecular dynamics (MD) simulations were conducted on four types of Cu-Cu3Sn interface structures with different orientations of Cu. By comparing the diffusion coefficients of atoms in those cases, it was found that the tensile stress would inhibit the diffusion of atoms, whereas compressive stress would accelerate it, and this would be more significant under a larger magnitude of stress and temperature. Note that, in the model with the (101) surface Cu at the interface, both Cu and Cu3Sn have a higher diffusion coefficient compared with the model with (001) surface Cu. Thus, the orientation of Cu will also contribute to the uniform consumption of the pad. Uniaxial tension simulation combined with DXA and CSP analyses on those models also shows the model with (001) surface Cu has a greater mechanical reliability in our simulation.
Graphical abstract
https://ift.tt/2vmpD71
Treatment of auricular keloids by triple combination therapy: Surgical excision, platelet‐rich plasma, and cryosurgery
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qBgZg5
An evaluation of the antiaging properties of strawberry hydrolysate treatment enriched with L‐ascorbic acid applied with microneedle mesotherapy
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H6LZuP
A single‐center, pilot study evaluating a novel TriHex peptide‐ and botanical‐containing eye treatment compared to baseline
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qBCUUn
Efficacy and safety of retinaldehyde 0.1% and 0.05% creams used to treat photoaged skin: A randomized double‐blind controlled trial
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H65inQ
Development of QSAR model for predicting the inclusion constants of organic chemicals with α -cyclodextrin
Abstract
Solubility is a crucial limiting factor in pharmaceutical research and contaminated site remediation. Cyclodextrin, with its structure of hydrophilic exterior and hydrophobic cavity, has a potential ability to enhance the hydrophobic chemical's solubility through the formation of host–guest complex. The stability of host–guest complex is often quantified by the inclusion constant. In this study, the logarithm of 1:1 α-cyclodextrin inclusion constants (log Kα ) for 195 organic chemicals was collected. With this parameter as the endpoint, a quantitative structure–activity relationship (QSAR) model was developed using DRAGON descriptors and stepwise multiple linear regression analysis. The model statistics parameters indicated that the established model had a good determination coefficient of 0.857, a high cross-validation coefficient of 0.835, a low root mean square error of 0.380, together with the acceptable results of external validation, which indicate a satisfactory goodness-of-fit, robustness, and predictive ability of the model. Based on the screened eight descriptors, we propose an appropriate mechanism interpretation for the inclusion interaction. Additionally, the applicability domain of the current model was characterized by the Euclidean distance-based method and Williams plot, and results indicated that the model covered a large number of structurally diverse chemicals belonging to 13 different classes. Comparing with the previous reported models, this model has obvious advantages with a larger dataset, a higher value of correlation coefficient, and a wider application domain.
https://ift.tt/2vjYVvT
Return of Oral Anticoagulation in Chronic Stable Coronary Disease.
Author: Verheugt, Freek W.A. MD
Page: 1655-1657
https://ift.tt/2H5EnwA
Continuing Conundrum of Multiple Arterial Conduits for Coronary Artery Bypass Grafting.
Author: Gaudino, Mario MD; Fremes, Stephen E. MD; Taggart, David P. MD, PhD
Page: 1658-1660
https://ift.tt/2qCrP4R
Association Between Hospital Volume, Processes of Care, and Outcomes in Patients Admitted With Heart Failure: Insights From Get With The Guidelines-Heart Failure.
Author: Kumbhani, Dharam J. MD, SM; Fonarow, Gregg C. MD; Heidenreich, Paul A. MD, MS; Schulte, Phillip J. PhD; Lu, Di MS; Hernandez, Adrian MD, MHS; Yancy, Clyde MD; Bhatt, Deepak L. MD, MPH
Page: 1661-1670
https://ift.tt/2H3yNe4
Getting to Dry.
Author: Zalawadiya, Sandip MD; Stevenson, Lynne Warner MD
Page: 1684-1687
https://ift.tt/2H85VBC
Particulate Matter Air Pollution Exposure and Heart Disease Mortality Risks by Race and Ethnicity in the United States: 1997 to 2009 National Health Interview Survey With Mortality Follow-Up Through 2011.
Author: Parker, Jennifer D. PhD; Kravets, Nataliya MA; Vaidyanathan, Ambarish PhD
Page: 1688-1697
https://ift.tt/2qBwS5y
Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine.
Author: Gao, Ling PhD; Gregorich, Zachery R. PhD; Zhu, Wuqiang MD, PhD; Mattapally, Saidulu PhD; Oduk, Yasin PhD; Lou, Xi BS; Kannappan, Ramaswamy PhD; Borovjagin, Anton V. PhD; Walcott, Gregory P. PhD; Pollard, Andrew E. PhD; Fast, Vladimir G. PhD; Hu, Xinyang MD, PhD; Lloyd, Steven G. MD, PhD; Ge, Ying PhD; Zhang, Jianyi MD, PhD
Page: 1712-1730
https://ift.tt/2H4yaB7
Role of Invasive Functional Assessment in Surgical Revascularization of Coronary Artery Disease.
Author: Baibhav, Bipul MD; Gedela, Maheedhar MD; Moulton, Michael MD; Pavlides, Gregory MD, PhD; Pompili, Vincent MD; Rab, Tanveer MD; Dangas, George MD; Bhatt, Deepak L. MD, MPH; Siddique, Aleem MBBS *,; Chatzizisis, Yiannis S. MD, PhD *,
Page: 1731-1739
https://ift.tt/2qEg3ab
Cardiac Arrest With ST-Segment-Elevation in V1 and V2: Differential Diagnosis.
Author: Arroyo Rivera, Belen MD; Acena, Alvaro MD, PhD; Sanchez-Borque, Pepa MD; Orejas, Miguel MD, PhD; Tunon, Jose MD, PhD
Page: 1742-1744
https://ift.tt/2qDnE8T
Inpatient Echocardiography Use for Common Cardiovascular Conditions.
Author: Pack, Quinn R. MD, MSc; Priya, Aruna MA, MSc; Lagu, Tara C. MD, MPH; Pekow, Penelope S. PhD; Schilling, Joshua P. MD; Hiser, William L. MD; Lindenauer, Peter K. MD, MSc
Page: 1745-1747
https://ift.tt/2H7Y7zF
Letter by Bulluck and Hausenloy Regarding Article, "Dynamic Edematous Response of the Human Heart to Myocardial Infarction: Implications for Assessing Myocardial Area at Risk and Salvage".
Author: Bulluck, Heerajnarain MD, PhD; Hausenloy, Derek J. MBChB, PhD
Page: 1748-1749
https://ift.tt/2qDnAWH
Letter by Sacha and Feusette Regarding Article, "Dynamic Edematous Response of the Human Heart to Myocardial Infarction: Implications for Assessing Myocardial Area at Risk and Salvage".
Author: Sacha, Jerzy MD, PhD; Feusette, Piotr MD
Page: 1750-1751
https://ift.tt/2H3yMa0
Letter by Stiermaier et al Regarding Article, "Dynamic Edematous Response of the Human Heart to Myocardial Infarction: Implications for Assessing Myocardial Area at Risk and Salvage".
Author: Stiermaier, Thomas MD; Bogaert, Jan MD, PhD; Eitel, Ingo MD
Page: 1752-1753
https://ift.tt/2qBidXS
Response by Fernandez-Jimenez et al to Letters Regarding Article, "Dynamic Edematous Response of the Human Heart to Myocardial Infarction: Implications for Assessing Myocardial Area at Risk and Salvage".
Author: Fernandez-Jimenez, Rodrigo MD, PhD; Martin-Garcia, Ana MD, PhD; Barreiro-Perez, Manuel MD, PhD; Sanchez-Gonzalez, Javier PhD; Fuster, Valentin MD, PhD; Sanchez, Pedro L. MD, PhD; Ibanez, Borja MD, PhD
Page: 1754-1755
https://ift.tt/2H5DUKQ
Letter by Jin-shan and Xue-bin Regarding Article, "Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis".
Author: Jin-shan, He MD; Xue-bin, Li MD
Page: 1756
https://ift.tt/2qDnoqr
Response by Liu to Letter Regarding Article, "Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis".
Author: Liu, Qinghang MD, PhD
Page: 1757-1758
https://ift.tt/2H1TAia
Letter by Mewton et al Regarding Article, "Validity of Cardiovascular Data From Electronic Sources: The Multi-Ethnic Study of Atherosclerosis and HealthLNK".
Author: Mewton, Nathan MD, PhD; Bergerot, Cyrille MD; Cornu, Catherine MD, PhD
Page: 1759-1760
https://ift.tt/2qBhTIE
Association between nasopharyngeal carcinoma and risk of optic neuropathy: A population‐based cohort study
Head &Neck, EarlyView.
https://ift.tt/2H4jzkV
Effects of different vermicompost extracts of palm oil mill effluent and palm-pressed fiber mixture on seed germination of mung bean and its relative toxicity
Abstract
Several treatment technologies are available for the treatment of palm oil mill wastes. Vermicomposting is widely recognized as efficient, eco-friendly methods for converting organic waste materials to valuable products. This study evaluates the effect of different vermicompost extracts obtained from palm oil mill effluent (POME) and palm-pressed fiber (PPF) mixtures on the germination, growth, relative toxicity, and photosynthetic pigments of mung beans (Vigna radiata) plant. POME contains valuable nutrients and can be used as a liquid fertilizer for fertigation. Mung bean seeds were sown in petri dishes irrigated with different dilutions of vermicomposted POME-PPF extracts, namely 50, 60, and 70% at varying dilutions. Results showed that at lower dilutions, the vermicompost extracts showed favorable effects on seed germination, seedling growth, and total chlorophyll content in mung bean seedlings, but at higher dilutions, they showed inhibitory effects. The carotenoid contents also decreased with increased dilutions of POME-PPF. This study recommends that the extracts could serve as a good source of fertilizer for the germination and growth enhancement of mung bean seedlings at the recommended dilutions.
https://ift.tt/2JOq5yl
Issue Information
Journal of Neuroendocrinology, Volume 30, Issue 4, April 2018.
https://ift.tt/2ET6Wrc
Analgetikabedarf bei Kindern im Alter zwischen 2 und 12 Jahren nach Tonsillenoperationen
Laryngo-Rhino-Otol
DOI: 10.1055/a-0596-7675
Hintergrund Mandeloperationen bei Kindern zählen zu den schmerzhaftesten Eingriffen. Altersgerechte Schmerzskalen sind die Kindliche Unbehagens- und Schmerzskala (KUSS), die Faces Pain Scale–Revised (FPS-R) und der kaum bekannte PPPM-D-Fragebogen. Ziel war Evaluation der Analgesie bei durch Eltern angeforderter Nichtopioid-Medikation (NOM) mit Ibuprofen (IBU) und Paracetamol (PCM) nach intrakapsulärer Tonsillektomie (TO) oder extrakapsulärer Tonsillektomie (TE). Als Rescue-Medikation (RM) wurde nach Prüfung der Schmerzskalen Piritramid appliziert. Endpunkte waren Anteil der Patienten (PAT), der die RM benötigte, Menge applizierter NOM, Übereinstimmung der Indikation in verschiedenen Schmerzskalen, Korrelation von Schmerzen mit Prämedikation und Eingriffsdauer. Material/Methoden Postoperativ erfolgten 3 Messungen täglich mit KUSS bei PAT ≤ 4 Jahre bzw. FPS-R ≥ 5 Jahre. Eltern füllten den PPPM-D aus. Bei einem Wert ≥ 4 bei KUSS bzw. FPS-R oder ≥ 6 im PPPM-D wurde die RM indiziert. Ergebnisse 68 PAT wurden in eine Zwischenauswertung eingeschlossen. Durchschnittliche tägliche NOM in den ersten 3 Tagen: nach TE 14,1–16,3 mg/Kg IBU und 4,2–12,4 mg/Kg PCM bzw. nach TO 10,8–14,7 mg/Kg IBU und 5,2–8,8 mg/Kg PCM. Bei 212 Visiten wurde die RM indiziert, davon 121 Mal nur durch den PPPM-D. Nach Ausschluss eventuell falsch-positiver Indikationen benötigten 67 % der PAT nach TE und 48 % der PAT nach TO mindestens einmal die RM. Die Studie wurde wegen des hohen RM-Bedarfs abgebrochen. Schlussfolgerungen Der Bedarf an NOM wurde unterschätzt. Der PPPM-D kombiniert mit etablierten Skalen kann die postoperative Schmerztherapie verbessern.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Issue Information ‐ TOC
https://ift.tt/2vmdZZS
Seasonal variation in prey composition and digestion in small mammal predator assemblages
International Journal of Osteoarchaeology, EarlyView.
https://ift.tt/2JQRjEv
Marginal adaptation of lithium disilicate ceramic crowns cemented with three different resin cements
Abstract
Objectives
The cementation process and cementation materials have an influence on the marginal adaptation of restorations. The gap could be affected by thermal and mechanical loading (TCML). The computerized x-ray microtomography (μCT) method offers the possibility of measuring the marginal gap without destruction of the restoration. The aim of this study was to evaluate the marginal gap (MG) and the absolute marginal discrepancy (AMD) before and after TCML.
Materials and methods
Thirty-nine human premolars were prepared for full ceramic crowns made of lithium disilicate. The crowns were cemented by three different resins—Panavia F 2.0, Variolink II, and Relyx Unicem. The MG and AMD were evaluated by μCT before and after TCML.
Results
Panavia F 2.0 had the lowest MG (before 118 μm–after TMCL 124 μm) and AMD (before 145 μm–after TMCL 154 μm), followed by Relyx Unicem (MG: before 164 μm–after TCML 155 μm; AMD: before 213 μm–after TMCL 209 μm) and Variolink II (MG: before 317 μm–after TMCL 320 μm; AMD: before 412 μm–after TMCL 406 μm). The differences were statistically significant before and after TCML. Rather than TCML, it appeared the resin cement was responsible for differences between the MG and AMD before and after TCML.
Conclusions
μCT is an accurate technique for assessing cemented restorations. Panavia F 2.0 has the lowest MG and AMD before and after TCML.
Clinical relevance
The resin material that features a three-step protocol (Variolink II) produced higher MG and AMG values than the Panavia or Relyx Unicem varieties with less or no intermediate steps at all.
https://ift.tt/2vmdfE4
Physiology and pathophysiology of renal erythropoietin-producing cells.
| Related Articles |
Physiology and pathophysiology of renal erythropoietin-producing cells.
J Formos Med Assoc. 2018 Apr 11;:
Authors: Shih HM, Wu CJ, Lin SL
Abstract
Anemia is a common complication and contributes to increased morbidity and mortality in chronic kidney disease (CKD) patients. Whereas there has been a significant improvement of understanding the underlying mechanism of erythropoiesis, the treatment of renal anemia is still restricted to erythropoietin (EPO)-stimulating agents. The purpose of this article is to review the physiology of erythropoiesis, functional role of EPO and underlying molecular and cellular basis that regulate EPO production. Regulation of EPO production is at mRNA level. When anemia or hypoxia occurs, transcriptional factor, hypoxia-inducible factor (HIF), binds to EPO 5' hypoxic response element and EPO gene transcription increases. The renal EPO is mainly produced by pericytes. In CKD, pericytes transdifferentiate to myofibroblasts, and subsequently the ability of EPO production decreases, leading to renal anemia. Recent experimental and clinical studies show the promising efficacy of prolyl hydroxylase inhibitors in renal anemia through increasing EPO production by stabilizing HIF. Recent advances on epigenetics create a new field to study EPO gene expression at chromatin level. We will discuss the role of demethylating agent on restoring EPO expression, providing a novel approach to the treatment of renal anemia.
PMID: 29655605 [PubMed - as supplied by publisher]
https://ift.tt/2qC7PPI
Omental Vascularized Lymph Node Flap: A Radiographic Analysis
J reconstr Microsurg
DOI: 10.1055/s-0038-1642637
Background Vascularized lymph node transfer is an increasingly popular option for the treatment of lymphedema. The omental donor site is advantageous for its copious soft tissue, well-defined collateral circulation, and large number of available nodes, without the risk of iatrogenic lymphedema. The purpose of this study is to define the anatomy of the omental flap in the context of vascularized lymph node harvest. Methods Consecutive abdominal computed tomography angiography (CTA) images performed at a single institution over a 1-year period were reviewed. Right gastroepiploic artery (RGEA) length, artery caliber, lymph node size, and lymph node location in relation to the artery were recorded. A two-tailed Z-test was used to compare means. A Gaussian Mixture Model confirmed by normalized entropy criterion was used to calculate three-dimensional lymph node cluster locations along the RGEA. Results In total, 156 CTA images met inclusion criteria. The RGEA caliber at its origin was significantly larger in males compared with females (p < 0.001). An average of 3.1 (1.7) lymph nodes were present per patient. There was no significant gender difference in the number of lymph nodes identified. Average lymph node size was significantly larger in males (4.9 [1.9] × 3.3 [0.6] mm in males vs. 4.5 [1.5] × 3.1 [0.5] mm in females; p < 0.001). Three distinct anatomical variations of the RGEA course were noted, each with a distinct lymph node clustering pattern. Total lymph node number and size did not differ among anatomical subgroups. Conclusion The omentum is a reliable lymph node donor site with consistent anatomy. This study serves as an aid in preoperative planning for vascularized lymph node transfer using the omental flap.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Free versus Pedicled Perforator Flaps for Lower Extremity Reconstruction: A Multicenter Comparison of Institutional Practices and Outcomes
J reconstr Microsurg
DOI: 10.1055/s-0038-1639576
Background Of all body regions, lower extremity wounds have been and remain the greatest challenge. Perforator free flaps have been accepted as a reasonable option to solve this dilemma but require the complexity of microsurgery. As a consequence, the possibility that pedicled perforator flaps could supplant even perforator free flaps has recently gained intense enthusiasm. Methods A retrospective investigation was undertaken to compare the validity for the use of perforator flaps of all types at three dissimilar institutions, that is, a university, a regional center, and a community hospital. All flaps performed in the 5-year period, 2011 to 2015, were included to allow at least 1-year follow-up before data analysis. A total of 433 free perforator flaps and 52 pedicled perforator flaps had been performed specifically for the lower extremity. Results Patient demographics, wound etiology, and comorbidities were similar for all institutions. Free flaps were more commonly needed after trauma and for chronic ulcers. Pedicled flaps were more likely an option after tumor excision. Large defects or those involving the foot were better served by free flaps. Overall success for free perforator flaps was 90.1% and for pedicled perforator flaps was 92.3%, with no significant difference noted (p = 0.606) between institutions. Peripheral vascular disease was the only significant comorbidity risk factor for both free and pedicled flap failure. Conclusion Perforator flaps in general have become a reasonable solution for soft tissue defects of the lower extremity. Following careful consideration of the etiology, dimensions, location, patient comorbidities, and presence of adequate perforators, a pedicled or free perforator flap could potentially be successful. Pedicled perforator flaps, if adequate healthy soft tissues remain adjacent to the defect, forecast a continuance of the evolution in seeking simplicity yet reliability by the best flap possible for soft tissue closure of the lower limb wound.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology
Janus kinase inhibitors (JAKi) have attracted attention for their role in treating inflammatory disorders. This new class of biologics has the potential to significantly impact the field of dermatology, especially with the development of topical formulations.
https://ift.tt/2qCVhHO
Clinical features and prognosis of Asian patients with acral lentiginous melanoma who have nodal nevi in their sentinel lymph node biopsy specimen.
Nodal melanocytic nevi (NN) encountered during sentinel lymph node biopsy (SLB) for malignant melanoma are usually difficult to distinguish from metastatic melanoma. However, NN have not been studied well in acral lentiginous melanoma (ALM) in Asian populations.
https://ift.tt/2H839fO
A factor increasing venous contamination on bolus chase three-dimensional magnetic resonance imaging: Charcot neuroarthropathy
Mehmet B Cildag, Mustafa B Ertuğrul, Ömer FK Köseoğlu, David G Armstrong
Journal of Clinical Imaging Science 2018 8(1):13-13
Background: The study aimed to evaluate the ratio of venous contamination in diabetic cases without foot lesion, with foot lesion and with Charcot neuroarthropathy (CN). Materials and Methods: Bolus-chase three-dimensional magnetic resonance (MR) of 396 extremities of patients with diabetes mellitus was analyzed, retrospectively. Extremities were divided into three groups as follows: diabetic patients without foot ulcer or Charcot arthropathy (Group A), patients with diabetic foot ulcers (Group B) and patients with CN accompanying diabetic foot ulcers (Group C). Furthermore, amount of venous contamination classified as no venous contamination, mild venous contamination, and severe venous contamination. The relationship between venous contamination and extremity groups was investigated. Results: Severe venous contamination was seen in Group A, Group B, and Group C, 5.6%, 15.2%, and 34.1%, respectively. Statistically significant difference was seen between groups with regard to venous contamination. Conclusion: Venous contamination following bolus chase MR was higher in patients with CN.
https://ift.tt/2qB9vZS
Journal of Clinical Imaging Science 2018 8(1):13-13
Background: The study aimed to evaluate the ratio of venous contamination in diabetic cases without foot lesion, with foot lesion and with Charcot neuroarthropathy (CN). Materials and Methods: Bolus-chase three-dimensional magnetic resonance (MR) of 396 extremities of patients with diabetes mellitus was analyzed, retrospectively. Extremities were divided into three groups as follows: diabetic patients without foot ulcer or Charcot arthropathy (Group A), patients with diabetic foot ulcers (Group B) and patients with CN accompanying diabetic foot ulcers (Group C). Furthermore, amount of venous contamination classified as no venous contamination, mild venous contamination, and severe venous contamination. The relationship between venous contamination and extremity groups was investigated. Results: Severe venous contamination was seen in Group A, Group B, and Group C, 5.6%, 15.2%, and 34.1%, respectively. Statistically significant difference was seen between groups with regard to venous contamination. Conclusion: Venous contamination following bolus chase MR was higher in patients with CN.
https://ift.tt/2qB9vZS
Laboratory Tests, Liver Vessels Color Doppler Sonography, and FibroScan Findings in Patients with Nonalcoholic Fatty Liver Disease: An Observation Study
Ahmad Alizadeh, Fariborz Mansour-Ghanaei, Ava Roozdar, Farahnaz Joukar, Masood Sepehrimanesh, Seyedeh Amineh Hojati, Alireza Mansour-Ghanaei
Journal of Clinical Imaging Science 2018 8(1):12-12
Objective: Determination of the amount of parenchymal damage in nonalcoholic fatty liver disease (NAFLD) is crucial to choose the best treatment and management. Aim: Here, the associations between laboratory data and severity of steatosis and fibrosis plus hepatic vessel Doppler indices in NAFLD patients were investigated. Patients and Methods: Fifty patients (20 males and 30 females) with NAFLD criteria were enrolled. Fatty liver was graded by sonography (SGFL) and FibroScan (FGFL). In addition, liver fibrosis was graded through FGLF. Damages to the portal, hepatic, and splenic veins were evaluated by color Doppler/dopplex. Serum liver enzymes and C-reactive protein (CRP) were also measured. Results: Significant association existed between SGFL and FGFL (P = 0.006). Portal vein pulsatility index (PI) and phasicity plus the triphasic and monophasic pattern of hepatic veins significantly associated with fatty liver grade evaluated by sonography. Splenic vein Peak systolic velocity and PI showed significant association with FGFL. Eventually, elevated liver enzymes and CRP significantly correlated with FGLF. Conclusion: We found that the severity of fatty liver is correlated with hepatic and portal veins damages; however, the degree of parenchymal fibrosis was independent to these indices and can be directly evaluated by FGFL. In addition, elevated liver enzymes and CRP correlated with the degree of fibrosis.
https://ift.tt/2H1yWPc
Journal of Clinical Imaging Science 2018 8(1):12-12
Objective: Determination of the amount of parenchymal damage in nonalcoholic fatty liver disease (NAFLD) is crucial to choose the best treatment and management. Aim: Here, the associations between laboratory data and severity of steatosis and fibrosis plus hepatic vessel Doppler indices in NAFLD patients were investigated. Patients and Methods: Fifty patients (20 males and 30 females) with NAFLD criteria were enrolled. Fatty liver was graded by sonography (SGFL) and FibroScan (FGFL). In addition, liver fibrosis was graded through FGLF. Damages to the portal, hepatic, and splenic veins were evaluated by color Doppler/dopplex. Serum liver enzymes and C-reactive protein (CRP) were also measured. Results: Significant association existed between SGFL and FGFL (P = 0.006). Portal vein pulsatility index (PI) and phasicity plus the triphasic and monophasic pattern of hepatic veins significantly associated with fatty liver grade evaluated by sonography. Splenic vein Peak systolic velocity and PI showed significant association with FGFL. Eventually, elevated liver enzymes and CRP significantly correlated with FGLF. Conclusion: We found that the severity of fatty liver is correlated with hepatic and portal veins damages; however, the degree of parenchymal fibrosis was independent to these indices and can be directly evaluated by FGFL. In addition, elevated liver enzymes and CRP correlated with the degree of fibrosis.
https://ift.tt/2H1yWPc
Functional and anatomical results of inside out approach for cholesteatoma surgery
To study the efficacy of inside-out approach in completely eradicating the cholesteatoma from middle ear and mastoid, preservation of hearing & and quality of life post mastoidectomy with regards to recurrent discharge, wax, granulations.
https://ift.tt/2IX3Gxy
Surgeon-performed ultrasound for the assessment of parotid masses
Studies on parotid gland ultrasound assessments performed specifically by surgeons are seldom reported.
https://ift.tt/2HsKwlW
Evaluation of anatomical and round breast implant aesthetics and preferences in Dutch young lay and plastic surgeon cohort
Literature remains inconclusive on the attractiveness and natural aspect of anatomical breast implants and, so far, studies have failed to demonstrate the visible difference in practice as compared to round ones. This study was undertaken to evaluate: (1) whether lay and professional participants can distinguish between breasts augmented with either round or anatomical breast implants, (2) their opinion with regard to naturalness and attractiveness of these augmented breasts.
https://ift.tt/2H3GbWY
Improved outcomes of scar revision with use of polydioxanone suture in comparison to polyglactin 910: A randomized controlled trial
Scars have multiple cosmetic and functional sequelae and revision surgeries are an attempt to ameliorate these effects. Reduction of spread of the revised scar is one of the main objectives of revision procedures. Provision of prolonged dermal support to wound can theoretically reduce spread of the scar. We carried out a randomized controlled trial and objectively evaluated the impact of two commonly used absorbable sutures, Polyglactin 910 and Polydioxanone on scar spread and quality. Sixty patients with post traumatic scars of one year duration were enrolled in the study and randomly divided into two groups of 30 each.
https://ift.tt/2qC3lbX
Masseter-to-facial nerve transfer: technique and outcomes utilizing a fibrin sealant for coaptation
BackgroundThis article describes the use of fibrin sealant for nerve coaptation without sutures in masseter-to-facial nerve transfer; and the results obtained utilizing this technique in a series of eleven patients.MethodsA retrospective review of eleven patients with facial paralysis grades V-VI was performed. All patients underwent masseter nerve transfer for facial reanimation utilizing a fibrin sealant, without utilizing sutures for coaptation.ResultsThe follow up period ranged from 10 to 52 months.
https://ift.tt/2H2suaB
Mollie lentaigne, the nurse who drew mcindoe's Guinea pigs: exploring the role of a medical artist at the queen victoria hospital, 1940-1945
Mollie Lentaigne was a medical artist who worked at the Queen Victoria Hospital in East Grinstead during the Second World War alongside Archibald McIndoe and his dedicated team. She drew hundreds of medical illustrations for McIndoe and his fellow surgeons during the years between 1940 and 1945. Her illustrations depict the plastic surgery that was carried out in that hospital on the badly burnt RAF servicemen injured during the war that took place in the skies over Europe, which included many aircrew injured during the Battle of Britain.
https://ift.tt/2qCgFNr
Management of laryngeal cleft in mechanically ventilated children with severe comorbidities
Laryngeal clefts are rare congenital malformations of the posterior part of the larynx. The severities are correlated with the downward extension of the cleft and can involve numerous clinical symptoms including dysphagia and respiratory distress. As significant comorbidities may be present, individual treatments depend on the child's general condition and type of cleft involved. Herein, we describe two cases of children with laryngeal clefts and severe comorbidities requiring mechanical ventilation.
https://ift.tt/2qBgHFt
Association between site‐specific bone mineral density and glucose homeostasis and anthropometric traits in healthy men and women
Clinical Endocrinology, EarlyView.
https://ift.tt/2ER0OzG
Extensive nevus comedonicus, complicated with recurrent abscesses, successfully treated with surgical resurfacing
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):33-37
Nevus comedonicus is a rare epidermal abnormality of the pilosebaceous unit, which is congenital in most patients but may also appear early in childhood. It may be localized or have an extensive involvement, the latter showing a unilateral predominance with only a few cases presenting bilaterally. Extensive nevus comedonicus can be associated with musculoskeletal defects, eye and neurological involvement, which constitutes nevus comedonicus syndrome. Uncomplicated nevus comedonicus can be treated with topical keratolytics, diode, erbium laser, and ultrapulse CO2 laser. Surgical excision can be performed to ensure complete removal and nonrecurrence. This case report refers to a young male patient with extensive nevus comedonicus present over left chest, left axilla, and left upper back without systemic involvement, treated with staged surgical excision and resurfacing.
https://ift.tt/2ESL538
Piercing ear keloid: Excision using loupe magnification and topical liquid silicone gel as adjuvant
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):7-12
Background: Keloid is an abnormal growth of scar at the site of skin injury, which usually does not regress. It proliferates beyond the original scar. The ear keloid usually develops after piercing injury to wear ornaments. A patient usually asks for removal of keloid, as it is aesthetically unpleasant. Patient may sometimes complain of itching and pain. Aim: The study was conducted to analyze results following excision of keloid with its tract and topical silicone gel as the postsurgical adjuvant. Materials and Methods: Ear keloids measuring less than 0.5cm or more than 5cm in maximum dimension were excluded from the study. Nonpiercing causes such as burns, trauma, and recurrent keloid were excluded from the study. The study was carried out on 22 patients who had keloid because of piercing injury, including 4 cases with both ear keloids. Of 26 ear keloids, 19 had the tract or connecting tissue. The lesion was excised under anesthesia using magnification. For all the operated cases, topical liquid silicone gel was used as postsurgical adjuvant therapy. The method of application of topical silicone gel was taught to each patient and was considered significant. Result: The magnification helped in identification of tract in 73% of the cases in this study. Twenty patients had successfully responded to proposed treatment, and two patients developed recurrence while using topical silicone gel as the adjuvant. These two patients were managed with conventional triamcinolone injection. Conclusion: The topical silicone gel as postsurgical adjuvant therapy avoided the use of painful postsurgical injection or radiotherapy for the 1–3cm primary ear keloids. The advantages of magnification were better clearance of keloid tissue, easier identification of tract and removal of keloid pseudopods, meticulous suturing, and comfortable elevation of a small local flap.
https://ift.tt/2EOKPlL
Suction blister epidermal grafting for vitiligo involving angles of lip: Experience of 112 patients
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):13-19
Background: Lip vitiligo is usually resistant to medical modalities of treatment, and in all these cases, surgery offers a hope. Suction blister grafting (SBG) has been tried since long for lip vitiligo with high rate of success. There have been no long-term follow-up studies of patients with SBG at a difficult-to-treat site like angles of lip, which prompted us to conduct this study. Aims and Objectives: To assess the pigmentation rate and patient satisfaction of SBG on vitiligo involving angles of lip. Materials and Methods: This is a prospective study conducted on 112 patients with stable vitiligo involving angles of lip. SBG was carried out in all the patients using the standard procedure. Patients were advised to apply topical psoralen followed by sun exposure (PUVASOL) for 8–12 weeks after operation. The patients were followed up at 3, 6, 12, 18, and 24 months for assessment of pigmentation and overall satisfaction. Results: We found a pigmentation success rate of 83.7%, 84.9%, 85.7%, 78.3%, and 77.8% in the patients who were followed up at 3, 6, 12, 18, and 24 months, respectively. A total of 77.8% of patients who came for follow-up at the end of 24 months were very happy with the treatment. Discussion: Our data show clearance of vitiligo and persistence of pigmentation gained through SBG in 77.8% of cases at the end of 2 years as well as excellent patient satisfaction in the cohort of patients who followed up with us. Conclusion: SBG is an easy and cost-effective way of repigmentation of vitiligo involving angles of lip.
https://ift.tt/2vjuztD
Carpal tunnel syndrome caused by intraneural lipoma of the median nerve and arteriovenous malformation
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):29-32
Carpal tunnel syndrome can be the result of a wide variety of etiologic factors. Compressive causes are rare and tumors causing compression are even rarer. We present a case with a carpal tunnel syndrome caused by an intraneural lipoma and an arteriovenous malformation concomitantly. The lesions were excised, and the patient recovered with full hand function and entire disappearance of acroparesthesia. To our knowledge, this is the first case report of carpal tunnel syndrome caused by an intraneural lipoma and an arteriovenous malformation concomitantly.
https://ift.tt/2HrciiJ
Resurfacing of facial acne scars with a new variable-pulsed Er:YAG laser in Fitzpatrick skin types IV and V
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):20-25
Introduction: The Er:YAG laser, considered to be less effective than CO2 laser in its traditional form, in its new modulated version has variable pulse technology that is claimed to be superior to the earlier versions of the laser. Aim: The aim of the study was to check efficacy and safety of the new variable square pulse (VSP) Er:YAG laser in the management of acne scar in patients with Fitzpatrick skin types IV and V. Materials and Methods: This retrospective study consisted of 80 patients (Fitzpatrick skin types IV and V) with atrophic and hypertrophic facial acne scars. Records of the patients who had undergone four treatment sessions with VSP technology equipped with Er:YAG laser were extracted. Each patient had undergone a minimum of four sessions. Fractional mode at medium laser pulse (SP) and long pulse (LP) was employed for the depressed center of the scars to stimulate neocollagenogenesis. Short laser pulse (MSP) in nonfractionated mode was used for ablating the raised scar border and hypertrophic scars. Goodman and Baron global scarring grading system was used for qualitative and quantitative assessments. Patient's satisfaction to the treatment and observer's assessment of improvement (based on photographs) was graded as poor (<25% improvement), fair (25–50% improvement), good (51–75% improvement), and excellent (>75% improvement). Results: At the end of the four sessions, the number of patients in grade IV postacne scarring reduced from 16 to 2 and that in grade III from 47 to 29. The mean score significantly dropped from 36.94 to 27.5. Subjective assessment revealed that 78 of 80 patients had noticed more than 25% improvement, with 50 of them showing more than 50% improvement at the end of four sessions. Eight patients perceived an excellent response and 42 reported a good response. This is notably higher than the observer's grading, which showed an excellent response in only 2 patients and a good response in 35. Adverse effects were limited to prolonged erythema (two patients), prolonged crusting (one patient), and postinflammatory hyperpigmentation (one patient). Conclusion: Ninety-seven percent of the subjects in our study perceived at least a fair improvement. We also saw a significant change in the objective score with a fall of the mean quantitative score from 36.94 to 27.15. This underscores the new variable-pulsed Er:YAG laser's effectiveness in the treatment of acne scars. It also has the added advantage of lesser adverse events and faster healing.
https://ift.tt/2EQ55DF
Wooden spatula for pain reduction in upper lip laser hair removal
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):38-39
https://ift.tt/2Huiu9M
Scalp defect reconstruction with triple rotation flap: A case report
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):26-28
Scalp surgeries are some of the surgeries frequently performed in dermatosurgery department. These surgical procedures may leave large defects, especially when performed for malignant condition in which wide margin has to be excised. Such large defects are difficult to close primarily when reconstruction with local flap is essential. Here we report a case of epithelioid angiosarcoma of the scalp in a 24-year-old man where excision and reconstruction were performed using triple rotation flap.
https://ift.tt/2viwsqd
Reconstruction of an anterior auricular defect through a tunnelized preauricular transposition flap
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):42-44
https://ift.tt/2Huimai
Comparison of tear proteome in allergic rhinoconjunctivitis patients and controls with respect to pollen season
Allergy, EarlyView.
https://ift.tt/2IWU0De
Ethnic differences in the association between maternal vitamin D status and offspring asthma and wheeze: Findings from the Born in Bradford cohort study
Allergy, EarlyView.
https://ift.tt/2HsOJWJ
The expression and distribution of a leptin receptor in the central nervous system, digestive organs, and gonads of the giant freshwater prawn, Macrobrachium rosenbergii.
| Related Articles |
The expression and distribution of a leptin receptor in the central nervous system, digestive organs, and gonads of the giant freshwater prawn, Macrobrachium rosenbergii.
Acta Histochem. 2018 Apr 11;:
Authors: Poljaroen J, Tinikul R, Anuracpreeda P, Sobhon P, Tinikul Y
Abstract
In the present study, the presence and distribution of leptin receptor (LEP-R) in central nervous system, digestive organs, gonads of giant freshwater prawn, Macrobrachium rosenbergii, were investigated with Western blot and immunohistochemistry. By Western blot a LEP-R with a molecular weight (MW) of 100 kDa was detected in the brain, thoracic ganglia, abdominal ganglia, hepatopancreas, all parts of the gastrointestinal tract, ovaries, and testes. In hepatopancreas and foregut, another intense positive band was detected at molecular weight of 30 kDa, which could be an isotype of LEP-R. By immunohistochemistry, LEP-R-ir was detected in the neurons, and neuropils in the brain, thoracic ganglia, and abdominal ganglia. In the gastrointestinal tract, there was intense LEP-R-ir in the apical part of the epithelial cells of the foregut, midgut, and hindgut. In addition, LEP-R-ir was found in the Restzellen(R)cells and Fibrillenzellen(F) cells in the hepatopancreas. In the ovary, LEP-R-ir was detected in early stage of oocytes and mature oocytes. Intense LEP-R-ir was observed in spermatogonia and spermatocytes of the small and orange claw male prawns. In addition, LEP-R was seen in the high epithelium of spermatic ducts from all male morphotypes. In summary, the detection of the LEP-R-ir suggests the existence of a LEP-R in several organs of M. rosenbergii. Through binding with leptin peptide, LEP-R may be an important signaling molecule that has critical functions in modulating and controlling food intake, energy expenditure, and reproduction in this prawn.
PMID: 29655854 [PubMed - as supplied by publisher]
https://ift.tt/2Hmgald
Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma—author's reply
Helicobacter, EarlyView.
https://ift.tt/2qDJLwE
Geographic Variation in the Treatment of U.S. Adult Heart Transplant Candidates
AbstractBackground
The current U.S. priority ranking for heart candidates is based on treatment intensity, not objective markers of severity of illness. This system may encourage centers to overtreat candidates.
ObjectivesThis study sought to describe national variation in the intensity of treatment of adult heart transplantation candidates and identify center-level predictors of potential overtreatment.
MethodsThe registrations of all U.S. adult heart transplantation candidates from 2010 to 2015 were collected from the SRTR (Scientific Registry of Transplant Recipients). "Potential overtreatment" was defined as treatment of a candidate who did not meet American Heart Association cardiogenic shock criteria with either high-dose inotropes or an intra-aortic balloon pump. Multilevel logistic regression and propensity score models were used to adjust for candidate variability at each center. Center-level variables associated with potential overtreatment were identified.
ResultsFrom 2010 to 2015, 108 centers listed 12,762 adult candidates who were not in cardiogenic shock for heart transplantation. Of these, 1,471 (11.6%) were potentially overtreated with high-dose inotropes or intra-aortic balloon pumps. In the bottom quartile of centers, only 2.1% of candidates were potentially overtreated compared with 27.6% at top quartile centers, an interquartile difference of 25.5% (95% confidence interval: 21% to 30%). Adjusting for candidate differences did not significantly alter the interquartile difference. Local competition with 2 or more centers increased the odds of potential overtreatment by 50% (adjusted odds ratio: 1.50; 95% confidence interval: 1.07 to 2.11).
ConclusionsThere is wide variation in the treatment practices of adult heart transplantation centers. Competition for transplantable donor hearts is associated with the potential overtreatment of hemodynamically stable candidates. Overtreatment may compromise the fair and efficient allocation of scarce deceased donor hearts.
https://ift.tt/2HEUHRU
Sex Differences in High-Intensity Statin Use Following Myocardial Infarction in the United States
AbstractBackground
Historically, women have been less likely than men to receive guideline-recommended statin therapy for the secondary prevention of myocardial infarction (MI).
ObjectivesThe authors examined contemporary sex differences in prescription fills for high-intensity statin therapy following an MI, overall and across population subgroups, and assessed whether sex differences were attenuated following recent efforts to reduce sex disparities in the use of cardiovascular disease preventive therapies.
MethodsThe authors studied 16,898 (26% women) U.S. adults <65 years of age with commercial health insurance in the MarketScan database, and 71,358 (49% women) U.S. adults ≥66 years of age with government health insurance through Medicare who filled statin prescriptions within 30 days after hospital discharge for MI in 2014 to 2015. The authors calculated adjusted women-to-men risk ratios and 95% confidence intervals (CIs) for filling a high-intensity statin prescription (i.e., atorvastatin 40 to 80 mg, and rosuvastatin 20 to 40 mg) following hospital discharge for MI.
ResultsIn 2014 to 2015, 56% of men and 47% of women filled a high-intensity statin following hospital discharge for MI. Adjusted risk ratios for filling a high-intensity statin comparing women with men were 0.91 (95% CI: 0.90 to 0.92) in the total population, 0.91 (95% CI: 0.89 to 0.92) among those with no prior statin use, and 0.87 (95% CI: 0.85 to 0.90) and 0.98 (95% CI: 0.97 to 1.00) for those taking low/moderate-intensity and high-intensity statins prior to their MI, respectively. Women were less likely than men to fill high-intensity statins within all subgroups analyzed, and the disparity was largest in the youngest and oldest adults and for those without prevalent comorbid conditions.
ConclusionsDespite recent efforts to reduce sex differences in guideline-recommended therapy, women continue to be less likely than men to fill a prescription for high-intensity statins following hospitalization for MI.
https://ift.tt/2HEUG0i
Transition Intervention for Adolescents With Congenital Heart Disease
AbstractBackground
There is little evidence regarding the efficacy of interventions to prepare adolescents with congenital heart disease (CHD) to enter adult care.
ObjectivesThe goal of this study was to evaluate the impact of a nurse-led transition intervention on lapses between pediatric and adult care.
MethodsA cluster randomized clinical trial was conducted of a nurse-led transition intervention for 16- to 17-year-olds with moderate or complex CHD versus usual care. The intervention group received two 1-h individualized sessions targeting CHD education and self-management skills. The primary outcome was excess time to adult CHD care, defined as the interval between the final pediatric and first adult cardiology appointments, minus the recommended time interval, analyzed by using Cox proportional hazards regression accounting for clustering. Secondary outcomes included scores on the MyHeart CHD knowledge survey and the Transition Readiness Assessment Questionnaire.
ResultsA total of 121 participants were randomized to receive the intervention (n = 58) or usual care (n = 63). At the recommended time of first adult appointment (excess time = 0), intervention participants were 1.8 times more likely to have their appointment within 1 month (95% confidence interval: 1.1 to 2.9; Cox regression, p = 0.018). This hazard increased with time; at an excess time of 6 months, intervention participants were 3.0 times more likely to have an appointment within 1 month (95% confidence interval: 1.1 to 8.3). The intervention group had higher scores at 1, 6, 12, and 18 months on the MyHeart knowledge survey (mixed models, p < 0.001) and the Transition Readiness Assessment Questionnaire self-management index (mixed models, p = 0.032).
ConclusionsA nurse-led intervention reduced the likelihood of a delay in adult CHD care and improved CHD knowledge and self-management skills. (Congenital Heart Adolescents Participating in Transition Evaluation Research [CHAPTER 2]; NCT01723332)
https://ift.tt/2HF7vIi
Effect of Aspirin Coadministration on the Safety of Celecoxib, Naproxen, or Ibuprofen
AbstractBackground
The safety of nonsteroidal anti-inflammatory drug (NSAID) and aspirin coadministration is uncertain.
ObjectivesThe aim of this study was to compare the safety of combining NSAIDs with low-dose aspirin.
MethodsThis analysis of the PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen) trial included 23,953 patients with osteoarthritis or rheumatoid arthritis at increased cardiovascular risk randomized to celecoxib, ibuprofen, or naproxen. The on-treatment population was used for this study. Outcomes included composite major adverse cardiovascular events, noncardiovascular death, gastrointestinal or renal events, and components of the composite. Cox proportional hazards models compared outcomes among NSAIDs stratified by aspirin use following propensity score adjustment. Kaplan-Meier analysis was used to compare the cumulative probability of events.
ResultsWhen taken without aspirin, naproxen or ibuprofen had greater risk for the primary composite endpoint compared with celecoxib (hazard ratio [HR]: 1.52; 95% confidence interval [CI]: 1.22 to 1.90, p <0.001; and HR: 1.81; 95% CI: 1.46 to 2.26; p <0.001, respectively). Compared with celecoxib, ibuprofen had more major adverse cardiovascular events (p < 0.05), and both ibuprofen and naproxen had more gastrointestinal (p < 0.001) and renal (p < 0.05) events. Taken with aspirin, ibuprofen had greater risk for the primary composite endpoint compared with celecoxib (HR: 1.27; 95% CI: 1.06 to 1.51; p < 0.01); this was not significantly higher with naproxen (HR: 1.18; 95% CI: 0.98 to 1.41; p = 0.08). Among patients on aspirin, major adverse cardiovascular events were similar among NSAIDs, and compared with celecoxib, ibuprofen had more gastrointestinal and renal events (p < 0.05), while naproxen had more gastrointestinal events (p < 0.05), without a difference in renal events. Similar results were seen on adjusted Kaplan-Meier analysis.
ConclusionsCelecoxib has a more favorable overall safety profile than naproxen or ibuprofen when taken without aspirin. Adding aspirin attenuates the safety advantage of celecoxib, although celecoxib is still associated with fewer gastrointestinal events than ibuprofen or naproxen and fewer renal events than ibuprofen. (Prospective Randomized Evaluation of Celecoxib Integrated Safety vs Ibuprofen or Naproxen [PRECISION]; NCT00346216)
https://ift.tt/2HDuZNM
Thyroid Hormones and Cardiovascular Function and Diseases
Abstract
Thyroid hormone (TH) receptors are present in the myocardium and vascular tissue, and minor alterations in TH concentration can affect cardiovascular (CV) physiology. The potential mechanisms that link CV disease with thyroid dysfunction are endothelial dysfunction, changes in blood pressure, myocardial systolic and diastolic dysfunction, and dyslipidemia. In addition, cardiac disease itself may lead to alterations in TH concentrations (notably, low triiodothyronine syndrome) that are associated with higher morbidity and mortality. Experimental data and small clinical trials have suggested a beneficial role of TH in ameliorating CV disease. The aim of this review is to provide clinicians dealing with CV conditions with an overview of the current knowledge of TH perturbations in CV disease.
https://ift.tt/2HDuZxg
Myocarditis in Patients Treated With Immune Checkpoint Inhibitors
AbstractBackground
Myocarditis is an uncommon, but potentially fatal, toxicity of immune checkpoint inhibitors (ICI). Myocarditis after ICI has not been well characterized.
ObjectivesThe authors sought to understand the presentation and clinical course of ICI-associated myocarditis.
MethodsAfter observation of sporadic ICI-associated myocarditis cases, the authors created a multicenter registry with 8 sites. From November 2013 to July 2017, there were 35 patients with ICI-associated myocarditis, who were compared to a random sample of 105 ICI-treated patients without myocarditis. Covariates of interest were extracted from medical records including the occurrence of major adverse cardiac events (MACE), defined as the composite of cardiovascular death, cardiogenic shock, cardiac arrest, and hemodynamically significant complete heart block.
ResultsThe prevalence of myocarditis was 1.14% with a median time of onset of 34 days after starting ICI (interquartile range: 21 to 75 days). Cases were 65 ± 13 years of age, 29% were female, and 54% had no other immune-related side effects. Relative to controls, combination ICI (34% vs. 2%; p < 0.001) and diabetes (34% vs. 13%; p = 0.01) were more common in cases. Over 102 days (interquartile range: 62 to 214 days) of median follow-up, 16 (46%) developed MACE; 38% of MACE occurred with normal ejection fraction. There was a 4-fold increased risk of MACE with troponin T of ≥1.5 ng/ml (hazard ratio: 4.0; 95% confidence interval: 1.5 to 10.9; p = 0.003). Steroids were administered in 89%, and lower steroids doses were associated with higher residual troponin and higher MACE rates.
ConclusionsMyocarditis after ICI therapy may be more common than appreciated, occurs early after starting treatment, has a malignant course, and responds to higher steroid doses.
https://ift.tt/2HHOYLq
Helicobacter pylori infection‐induced H3Ser10 phosphorylation in stepwise gastric carcinogenesis and its clinical implications
Helicobacter, EarlyView.
https://ift.tt/2IWHl3a
Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma—author's reply
Helicobacter, EarlyView.
https://ift.tt/2qDJLwE
Sentinel lymph node biopsy in 33 non‐melanoma skin cancers of the head and neck: A twelve‐year experience with long‐term follow‐up
Clinical Otolaryngology, EarlyView.
https://ift.tt/2HFnC8C
Hearing aids in patients with vestibular schwannoma: Interest of the auditory brainstem responses
Clinical Otolaryngology, EarlyView.
https://ift.tt/2H6XN09
Is routine histological tissue sampling during endoscopic dacryocystorhinostomy advantageous? A retrospective analysis of 213 patients
Clinical Otolaryngology, EarlyView.
https://ift.tt/2HHOpkM
Reliable sonographic features for nodal thyroglobulin to diagnose recurrent lymph node metastasis from papillary thyroid carcinoma
Clinical Otolaryngology, EarlyView.
https://ift.tt/2IY2zgS
The price of pain in chronic rhinosinusitis
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2EOpHff
Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2JOxnlu
Endoscopic and external approaches for orbital decompression: an analysis of trends from a U.S. perspective
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2vj7vLz
Factor analysis of the questionnaire of olfactory disorders in patients with chronic rhinosinusitis
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2JOxbTi
Partial resection of the middle turbinate during endoscopic sinus surgery for chronic rhinosinusitis does not lead to an increased risk of empty nose syndrome: a cohort study of a tertiary practice
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2EOpskl
High‐intensity focused ultrasound treatment after cryolipolysis may be used to reduce pain: Two case report
Dermatologic Therapy, EarlyView.
https://ift.tt/2H7iMUM
Exploring the combination of SSKI and topical heparin in a case of erythema nodosum migrans
Dermatologic Therapy, EarlyView.
https://ift.tt/2qBE7KJ
Efficacy and tolerability of a lotion containing triethyl citrate, ethyl linoleate, and GT peptide‐10 in the adjuvant treatment of hidradenitis suppurativa: Real‐life data
Dermatologic Therapy, EarlyView.
https://ift.tt/2H3D4OX
The expression change of RORγt, BATF, and IL‐17 in Chinese vitiligo patients with 308 nanometers excimer laser treatment
Dermatologic Therapy, EarlyView.
https://ift.tt/2qBs2oO
Radiotherapy in the management of classic Kaposi's sarcoma: A single institution experience from Northeast Turkey
Dermatologic Therapy, EarlyView.
https://ift.tt/2H4pI4Z
Two cases of large cell acanthoma successfully treated with photodynamic therapy
Dermatologic Therapy, EarlyView.
https://ift.tt/2qD58gN
Secukinumab: A positive outcome in a patient with severe psoriasis and HBV‐HCV co‐infection
Dermatologic Therapy, EarlyView.
https://ift.tt/2H7oR3a
Successful treatment with interleukin‐17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations
The Journal of Dermatology, EarlyView.
https://ift.tt/2qB0eks
Dacryocystitis mimicking erysipelas due to a giant dacryolith
The Journal of Dermatology, EarlyView.
https://ift.tt/2H3i9LJ
Pediatric case of generalized pustular psoriasis developing acute pancreatitis
The Journal of Dermatology, EarlyView.
https://ift.tt/2qD6IiJ
Linear immunoglobulin A bullous dermatosis limited to oral mucosa associated with ulcerative colitis
The Journal of Dermatology, EarlyView.
https://ift.tt/2H3CCQB
Efficacy and toxicity of ipilimumab used after nivolumab in patients with melanoma
The Journal of Dermatology, EarlyView.
https://ift.tt/2qCdWn6
Alteration of serum thymus and activation‐regulated chemokine level during biologic therapy for psoriasis: Possibility as a marker reflecting favorable response to anti‐interleukin‐17A agents
The Journal of Dermatology, EarlyView.
https://ift.tt/2H4qZch
Pilomatricoma with bullous‐like/anetodermic appearance: Possibly associated with matrix metalloproteinases
The Journal of Dermatology, Volume 45, Issue 4, Page 505-506, April 2018.
https://ift.tt/2qCVCKv
Issue Information
The Journal of Dermatology, Volume 45, Issue 4, Page 509-512, April 2018.
https://ift.tt/2H765sY
Expression of aurora kinase A expression in dermatofibrosarcoma protuberans
The Journal of Dermatology, Volume 45, Issue 4, Page 507-508, April 2018.
https://ift.tt/2qDVHxA
Issue Information
The Journal of Dermatology, Volume 45, Issue 4, Page i, 383-384, April 2018.
https://ift.tt/2H54Ydr
High‐intensity focused ultrasound treatment after cryolipolysis may be used to reduce pain: Two case report
Dermatologic Therapy, EarlyView.
https://ift.tt/2H7iMUM
Exploring the combination of SSKI and topical heparin in a case of erythema nodosum migrans
Dermatologic Therapy, EarlyView.
https://ift.tt/2qBE7KJ
Efficacy and tolerability of a lotion containing triethyl citrate, ethyl linoleate, and GT peptide‐10 in the adjuvant treatment of hidradenitis suppurativa: Real‐life data
Dermatologic Therapy, EarlyView.
https://ift.tt/2H3D4OX
The expression change of RORγt, BATF, and IL‐17 in Chinese vitiligo patients with 308 nanometers excimer laser treatment
Dermatologic Therapy, EarlyView.
https://ift.tt/2qBs2oO
Radiotherapy in the management of classic Kaposi's sarcoma: A single institution experience from Northeast Turkey
Dermatologic Therapy, EarlyView.
https://ift.tt/2H4pI4Z
Two cases of large cell acanthoma successfully treated with photodynamic therapy
Dermatologic Therapy, EarlyView.
https://ift.tt/2qD58gN
Secukinumab: A positive outcome in a patient with severe psoriasis and HBV‐HCV co‐infection
Dermatologic Therapy, EarlyView.
https://ift.tt/2H7oR3a
Malleostapedotomy in stapes revision surgery: Is an endoscopic approach possible?
The Laryngoscope, EarlyView.
https://ift.tt/2HDs8Vb
Has the management of pediatric mucoepidermoid carcinoma of the parotid gland changed?
The Laryngoscope, EarlyView.
https://ift.tt/2H4Q7vk
Acute sialadenitis associated with 2017–2018 influenza A infection: A case series
The Laryngoscope, EarlyView.
https://ift.tt/2HGduME
Earfold: A New Technique for Correction of the Shape of the Antihelix
The Laryngoscope, EarlyView.
https://ift.tt/2H1ImWT
The influential factors on the morphological changes of upper airway associated with mouth opening
The Laryngoscope, EarlyView.
https://ift.tt/2HEOsNY
Comparison of the seventh and eighth edition american joint committee on cancer oral cavity staging systems
The Laryngoscope, EarlyView.
https://ift.tt/2IZEcQ4
Merkel cell carcinoma in a patient treated with infliximab: Beware of the subcutaneous nodule
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2Hslnrv
Clinical features and repair options for nonmelanoma skin cancers of the eyebrow
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2vkoltb
A retrospective clinico‐pathological study comparing lichen planus pigmentosus with ashy dermatosis
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2Hsli7b
Maculopapular drug eruption induced by linagliptin
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2ER6HNj
Lymphocytic thrombophilic arteritis complicated by systemic involvement
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2qwSGA7
Merkel cell carcinoma in a patient treated with infliximab: Beware of the subcutaneous nodule
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2Hslnrv
Clinical features and repair options for nonmelanoma skin cancers of the eyebrow
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2vkoltb
A retrospective clinico‐pathological study comparing lichen planus pigmentosus with ashy dermatosis
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2Hsli7b
Maculopapular drug eruption induced by linagliptin
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2ER6HNj
Lymphocytic thrombophilic arteritis complicated by systemic involvement
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2qwSGA7
Cutis tricolor parvimaculata in ring chromosome 15 syndrome: A case report
Pediatric Dermatology, EarlyView.
https://ift.tt/2JOgBD0
Bibbidi bobbidi bald: Two “hairowing” tales of Princess Package hairstyles
Pediatric Dermatology, EarlyView.
https://ift.tt/2vjpcKM
Atypical aluminium patch tests in children with persistent itching postvaccinal nodules
Pediatric Dermatology, EarlyView.
https://ift.tt/2Hp5ySu
Pyoderma gangrenosum in an infant: A case report and review of the literature
Pediatric Dermatology, EarlyView.
https://ift.tt/2vgzE5P
Colchicine may be of therapeutic benefit in prurigo pigmentosa
Pediatric Dermatology, EarlyView.
https://ift.tt/2qB52af
Perinuclear antineutrophil cytoplasmic antibody–positive vasculitis, oligoarthritis, tendinitis, and myositis associated with isotretinoin in a 15‐year‐old boy: Case report and review of literature
Pediatric Dermatology, EarlyView.
https://ift.tt/2EQ6R7K
Chromhidrosis due to exogenous oxidizing heavy metals: Clinical and laboratory findings
Pediatric Dermatology, EarlyView.
https://ift.tt/2HoIFyr
Efficacy and safety of a new 5% minoxidil formulation in male androgenetic alopecia: A randomized, placebo‐controlled, double‐blind, noninferiority study
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H39YPv
Absence of human skin irritation and allergenic potential after repeated patch applications of a lamellar moisturizer
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qEk2U3
Comparative thermographic analysis at pre‐ and postcryolipolysis treatment: Clinical case report
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H4YxHd
Oleic acid enhances keratinocytes differentiation via the upregulation of miR‐203 in human epidermal keratinocytes
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qDa45v
Granulomatous tattoo reactions in permanent makeup of the eyebrows
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H0NvCC
Use of cosmetic products for treating certain diseases—Know the science
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qD9TqR
Literary reading and eating disorders: survey evidence of therapeutic help and harm
Abstract
Background
There is growing evidence for the efficacy of self-help bibliotherapy as a treatment for eating disorders, although little understanding of how specific linguistic characteristics may enhance or constrain its effects. Meanwhile, 'creative bibliotherapy' (the therapeutic use of fiction, poetry, or sometimes film, rather than self-help books) is widely practised, but even more poorly understood than the self-help variety: although a range of theoretical models exist, claims of the healing power of literature are far more commonly made than tested.
Methods
An online survey including quantitative (forced-choice) and qualitative (free-response) items was designed and administered in collaboration with the charity Beat to investigate the connections between respondents' reading habits and their mental health, with a focus on eating disorders, and attracted 885 respondents. Responses to two sequences of questions, exploring the differential effects of fiction about eating disorders versus respondents' preferred genre of other fiction on the dimensions of mood, self-esteem, feelings about one's body, and diet and exercise habits, were analysed using a 2 × 2 repeat measures factorial ANOVA design for each of the four dependent variables.
Results
Surprisingly, fiction about eating disorders was perceived by respondents as broadly detrimental to mood, self-esteem, feelings about their bodies, and diet and exercise habits, while respondents' preferred genre of other fiction was experienced as beneficial to mood and broadly neutral on the other three dimensions. The free-response data added detail to these core findings, as well as suggesting numerous other possible effects and mechanisms, drawing attention to the roles of positive and negative feedback structures and of highly selective interpretive filtering, and highlighting the dangers of 'self-triggering': using books to deliberately exacerbate an eating disorder.
Conclusions
The findings directly challenge existing theoretical models of creative-bibliotherapeutic mechanisms, which tend to insist on the importance of a close match between the reader's and the protagonist's situations. They point the way forward for a new programme of clinical research and practice by suggesting other ways to conceive of how embodied cognitive acts of textually cued interpretation may intervene in the psychopathology of an eating disorder – for good and for ill.
https://ift.tt/2qDRkma
Efficacy and safety of a new 5% minoxidil formulation in male androgenetic alopecia: A randomized, placebo‐controlled, double‐blind, noninferiority study
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H39YPv
Absence of human skin irritation and allergenic potential after repeated patch applications of a lamellar moisturizer
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qEk2U3
Comparative thermographic analysis at pre‐ and postcryolipolysis treatment: Clinical case report
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H4YxHd
Oleic acid enhances keratinocytes differentiation via the upregulation of miR‐203 in human epidermal keratinocytes
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qDa45v
Granulomatous tattoo reactions in permanent makeup of the eyebrows
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H0NvCC
Use of cosmetic products for treating certain diseases—Know the science
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qD9TqR
Modified maxillary reconstruction technique for Brown's class III defects by subdividing a rhomboid shaped iliac crest into 2 subunits
Head &Neck, EarlyView.
https://ift.tt/2J0A42a
Efficacy of a clinical pathway for patients with thyroid cancer
Head &Neck, EarlyView.
https://ift.tt/2HqJPd0
Endoscopic Sinonasal Dissection Guide Roy R. Casiano Thieme Medical Publishers, New York, NY, 2012, USD $64.07, 128 pages
Head &Neck, EarlyView.
https://ift.tt/2H2j4YN
MR lymphography for sentinel lymph node detection in patients with oral cavity cancer: Preliminary clinical study
Head &Neck, EarlyView.
https://ift.tt/2HrcuOU
Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival
Head &Neck, EarlyView.
https://ift.tt/2H4KEoi
Management of leaking tracheoesophageal puncture with hyaluronic acid injection
Head &Neck, EarlyView.
https://ift.tt/2Hs0qgd
Tongue cancer epidemiology in Brazil: incidence, morbidity and mortality
Head &Neck, EarlyView.
https://ift.tt/2J1MzKR
Patient with mediastinitis caused by delayed mucosal damage after peroral endoscopic myotomy.
Patient with mediastinitis caused by delayed mucosal damage after peroral endoscopic myotomy.
Asian J Endosc Surg. 2018 Apr 15;:
Authors: Okada H, Shiwaku H, Yamashita K, Ohmiya T, Inoue H, Hasegawa S
Abstract
Peroral endoscopic myotomy (POEM) is a groundbreaking procedure for treating esophageal achalasia, and many reports from various facilities have described its safety and efficacy. However, there have been few reports on adverse events. Here, we report a case of a patient with mediastinitis caused by delayed mucosal damage after POEM. This case was the most severe among all POEM cases at our hospital. A 58-year-old man had experienced dysphagia and chest tightness since he was around 50 years old. At a previous hospital, he had been diagnosed with nonerosive reflux disease and had undergone fundoplication. As his symptoms did not improve, he was referred to our department. POEM was able to be finished but a stable visual field could not be maintained throughout procedure because of strong esophageal contractions. From findings of endoscopy and esophagography after POEM, the patient was diagnosed mediastinitis caused by delayed esophageal perforation. In this case, conservative treatment (fasting, antibiotic therapy, and enteral feeding) was successful. However, the option to administer surgical treatment, such as drainage, must not be overlooked.
PMID: 29656451 [PubMed - as supplied by publisher]
https://ift.tt/2JPTXdI
In vivo reflectance confocal microscopy combined with the ‘spaghetti technique’ for the identification of surgical margins of lentigo maligna: experience in 70 patients
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2H4JysG
Generalized pustular psoriasis: a review and update on treatment
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2HqGydz
Who will treat inflammatory skin diseases in the year 2020?
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2H3il9z
Oral psoriasis and SIBO: is there a link?
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2HqGtGN
Circular RNA expression profile analysis of severe acne by RNA‐Seq and bioinformatics
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2H4Jfy2
Google search trends in psoriasis: a pilot evaluation of global population interests
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2qBAAgt
Efficacy of suplatast tosilate in a case of recurrent eosinophilic annular erythema
International Journal of Dermatology, EarlyView.
https://ift.tt/2H1KuSt
Lichen striatus following scarlet fever in a 3‐year‐old female patient
International Journal of Dermatology, EarlyView.
https://ift.tt/2qH0nTJ
Granulocyte colony‐stimulating factor‐producing melanoma treated with the combination of dabrafenib and trametinib
International Journal of Dermatology, EarlyView.
https://ift.tt/2H35wAi
Vedolizumab‐induced acne in inflammatory bowel disease
International Journal of Dermatology, EarlyView.
https://ift.tt/2qH02jV
Concentric targetoid scaly plaques in a patient with severe rheumatoid arthritis
International Journal of Dermatology, EarlyView.
https://ift.tt/2H4U1sl
Heavily pigmented fibroepithelioma of Pinkus mimicking melanoma
International Journal of Dermatology, EarlyView.
https://ift.tt/2qC6isU
Gray‐bluish cutaneous pigmentation and ice‐pick scars induced by vandetanib therapy
International Journal of Dermatology, EarlyView.
https://ift.tt/2H4n5zQ
Transient improvement of skin symptoms in an adult patient with pediatric‐onset cutaneous mastocytosis treated with interferon‐α
International Journal of Dermatology, EarlyView.
https://ift.tt/2qGZnir
A review of bullous pemphigoid associated with PD‐1 and PD‐L1 inhibitors
International Journal of Dermatology, EarlyView.
https://ift.tt/2H30804
Issue Information
International Journal of Dermatology, Volume 57, Issue 5, Page i-iii,503-504, May 2018.
https://ift.tt/2qEieKL
Teaching & Learning Tips 7: small‐group discussion
International Journal of Dermatology, Volume 57, Issue 5, Page 583-586, May 2018.
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A case of pigmentary mosaicism associated with diploid/triploid mixoploidy
International Journal of Dermatology, EarlyView.
https://ift.tt/2qBjRsM
Religious stigmata: a dermato‐psychiatric approach and differential diagnosis
International Journal of Dermatology, EarlyView.
https://ift.tt/2H37517
Lichen planus pigmentosus – An appraisal
International Journal of Dermatology, EarlyView.
https://ift.tt/2qCIbdz
Polyfunctionality of CD4 + T lymphocytes is increased after chemoradiotherapy of head and neck squamous cell carcinoma
Abstract
Background
For head and neck squamous cell cancer (HNSCC), standard therapy consists of surgery, radiation, and/or chemotherapy. Antineoplastic immunotherapy could be an option in an adjuvant setting and is already in palliation. A functional immune system is a prerequisite for successful immunotherapy. However, effects of the standard-of-care therapy on the patients' immune system are not fully understood.
Methods
Peripheral blood mononuclear cells (PBMC) were collected from patients with HNSCC (n = 37) and healthy controls (n = 10). PBMC were stimulated with staphylococcal enterotoxin B (SEB). Simultaneous expression of various cytokines was measured in CD4+ and CD8+ T cells by multicolor flow cytometry, and polyfunctional cytokine expression profiles were determined on a single-cell basis.
Results
Expression levels of all measured cytokines in CD4+ T cells were higher in patients after chemoradiotherapy (CRT) as compared to untreated HNSCC patients or normal controls. After CRT, the frequency of polyfunctional CD4+ T cells, which simultaneously expressed multiple cytokines, was significantly increased as compared to untreated patients (p < 0.01).
Conclusion
CRT increases polyfunctionality of CD4+ T cells in HNSCC patients, suggesting that standard-of-care therapy can promote immune activity in immune cells. These polyfunctional CD4+ T cells in the blood of treated HNSCC patients are expected to be responsive to subsequent immunotherapeutic approaches.
https://ift.tt/2qANWcJ
Molecular interactions at the surface of extracellular vesicles
Abstract
Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large oncosomes have been shown to participate in a wide variety of biological processes and are currently under intense investigation in many different fields of biomedicine. One of the key features of extracellular vesicles is that they have relatively large surface compared to their volume. Some extracellular vesicle surface molecules are shared with those of the plasma membrane of the releasing cell, while other molecules are characteristic for extracellular vesicular surfaces. Besides proteins, lipids, glycans, and nucleic acids are also players of extracellular vesicle surface interactions. Being secreted and present in high number in biological samples, collectively extracellular vesicles represent a uniquely large interactive surface area which can establish contacts both with cells and with molecules in the extracellular microenvironment. Here, we provide a brief overview of known components of the extracellular vesicle surface interactome and highlight some already established roles of the extracellular vesicle surface interactions in different biological processes in health and disease.
https://ift.tt/2qABJob
A multi-omic study reveals BTG2 as a reliable prognostic marker for early-stage non-small cell lung cancer.
A multi-omic study reveals BTG2 as a reliable prognostic marker for early-stage non-small cell lung cancer.
Mol Oncol. 2018 Apr 15;:
Authors: Shen S, Zhang R, Guo Y, Loehrer E, Wei Y, Zhu Y, Yuan Q, Moran S, Fleischer T, Bjaanaes MM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, Su L, Chen F, Christiani DC
Abstract
B-cell translocation gene 2 (BTG2) is a tumor suppressor protein and is known to be downregulated in several types of cancer. In this study, we investigated a potential role for BTG2 in early-stage non-small cell lung cancer (NSCLC) survival. We analysed BTG2 methylation data from 1,230 early-stage NSCLC patients from five international cohorts, as well as gene expression data from 3,038 lung cancer cases from multiple cohorts. Three CpG probes (cg01798157, cg06373167, cg23371584) that detected BTG2 hypermethylation in tumor tissues were associated with lower overall survival. The prognostic model based on methylation could distinguish patient survival in the four cohorts [hazard ratio (HR) range, 1.51 to 2.21] and the independent validation set (HR = 1.85). In the expression analysis, BTG2 expression positively correlated with survival in each cohort (HR range, 0.28 to 0.68), which we confirmed with meta-analysis (HR = 0.61, 95%CI: 0.54-0.68). The three CpG probes all negatively correlated with BTG2 expression. Importantly, an integrative model of BTG2 methylation, expression and clinical information showed better predictive ability in the training set and validation set. In conclusion, the methylation and integrated prognostic signatures based on BTG2 are stable and reliable biomarkers for early-stage NSCLC. They may have new applications for appropriate clinical adjuvant trials and personalized treatments in the future.
PMID: 29656435 [PubMed - as supplied by publisher]
https://ift.tt/2IZAKVo
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