The role of the otolaryngologist in the evaluation and management of headaches

Publication date: Available online 7 July 2018

Source: American Journal of Otolaryngology

Author(s): Shirley Hu, Samuel Helman, Peter Filip, Jonathan Cabin, Patrick Colley

Abstract

Background

Headaches are commonly evaluated in otolaryngology and often represent a diagnostic dilemma. This review addresses rhinogenic headache as well as trigeminal neuralgia and migraine, both of which can masquerade as sinus headache and whose management increasingly involves otolaryngology intervention. Discussion considers diagnostic criteria and novel therapies and derives an algorithm for clinical decision-making.

Data sources

OVID MEDLINE, Cochrane Library, and Google Scholar databases.

Methods

A literature search was performed to identify relevant articles published in the past 10 years addressing the diagnosis and management of rhinogenic headache, trigeminal neuralgia and/or migraine.

Findings

Rhinogenic headache: Identification of the specific cause must be achieved before treatment. No studies have mentioned the effect of certain therapies on the amelioration of headache. New techniques of balloon dilation for sinusitis are controversial, and their use remains contingent on surgeon preference. Removal of mucosal contact points has been shown to benefit quality of life in patients with contact point headache. Trigeminal neuralgia: Microvascular decompression is considered the gold standard for treatment, but percutaneous therapies can be effective for achieving pain control. Migraine: Patients who report amelioration of symptoms after targeted botulinum toxin injection may benefit from definitive decompression or nerve avulsion. Patients with mucosal contact points may have less favorable outcomes with migraine surgery if they are not simultaneously addressed.

Conclusions

A comprehensive understanding of the diagnostic workup and therapeutic options available for common headache etiologies is key to the management of a patient presenting with headache attributed to a rhinogenic cause.

https://ift.tt/2J1KtKw

New challenges in the application of advanced oxidation processes

https://ift.tt/2KZb6S3

Preconceptional allergen immunization can induce offspring IL-17 secreting B cells (B17): do they share similarities with regulatory B10 cells?

Publication date: Available online 7 July 2018

Source: Allergologia et Immunopathologia

Author(s): Aline Aparecida de Lima Lira, Marília Garcia de-Oliveira, Amanda Harumi Sabô Inoue, Giovanna Rossi Beltrame, Alberto José da Silva Duarte, Jefferson Russo Victor

Abstract

Background

IL-17-producing B cells can be identified in both mice and human and were named B17 cells. The role of B17 cells still needs to be elucidated and its inflammatory or regulatory functions remain controversial.

Objective

We evaluate the effect of maternal immunization with OVA on offspring B cells that produces IL-17 and can show a regulatory potential by IL-10 production.

Methods

C57BL/6 WT, IL-10^−/− or CD28^−/− female mice were immunized or not with OVA in Alum, and immunized females were boosted after 10 and 20 days. Immunized and non-immunized females were mated, and pups from both groups were evaluated at 3 or 20 days old (d.o.). Some offspring from the aforementioned two groups were immunized with OVA at 3 d.o., boosted after 10 days and evaluated at 20 d.o.

Results

Maternal immunization with OVA induced offspring B cells to produce IL-17 at higher intensity compared to the control group of offspring at 3 d.o. This effect was maintained until 20 d.o. and even after neonatal immunization with OVA. The co-production of IL-10 on offspring IL-17 + B cells is up-regulated in response to maternal immunization with OVA. Maternal immunization with OVA on IL-10^−/− mice reveals reduced percentage and mean of fluorescence intensity of IL-17 on B cells of offspring.

Conclusion

Preconception OVA immunization can induce offspring B cells that produce IL-17 at higher intensity and co-produce mainly IL-10. This could be the reason why B17 cells had been described in the literature with controversial roles upon their regulatory function.

https://ift.tt/2tYmOpU

Salivary IgA Deficiency in a Patient with Cystic Fibrosis (genotype M470V/V520F)

Publication date: Available online 7 July 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Jessica Oh, David P McGarry, Nancy Joseph, Brian Peppers, Robert Hostoffer

https://ift.tt/2MYnra2

Pediatric Ambulatory Continuous Peripheral Nerve Blocks

Publication date: Available online 7 July 2018

Source: Anesthesiology Clinics

Author(s): Sible Antony, Harshad Gurnaney, Arjunan Ganesh

https://ift.tt/2lXVAuR

Regional Anesthesia and Analgesia for Acute Trauma Patients

Publication date: Available online 7 July 2018

Source: Anesthesiology Clinics

Author(s): Ian R. Slade, Ron E. Samet

https://ift.tt/2ub5j4U

What Can Regional Anesthesiology and Acute Pain Medicine Learn from “Big Data”?

Publication date: Available online 7 July 2018

Source: Anesthesiology Clinics

Author(s): Nabil M. Elkassabany, Stavros G. Memtsoudis, Edward R. Mariano

https://ift.tt/2lXQZZC

Prevention of Frey Syndrome

Publication date: Available online 7 July 2018

Source: Operative Techniques in Otolaryngology-Head and Neck Surgery

Author(s): Phillip K Pellitteri

Abstract

Frey syndrome (gustatory sweating) is a common and often times significant consequence of parotid gland surgery. The classic signs and symptoms include facial sweating, flushing, rubor and sensation of heat over the preauricular region during oral stimulation. These clinical findings may provoke quality of life changes, and thus, are considered significant. Both surgical and non- surgical treatment modalities have been advanced in the treatment of this disorder. Surgical treatment is aimed at prevention of the development of Frey syndrome and consists of a constellation of techniques which are designed to interpose tissue in the parotid surgical bed to act as a barrier to prevent aberrant parasympathetic fiber ingrowth and innervation to facial skin eccrine sweat glands. These techniques include: limiting the extent of parotid surgery when possible, use of local tissue as advancement or rotational flaps, autologous transfer of tissue, and use of allograft material.

https://ift.tt/2KUGuRK

Enhanced visualization of the surgical field in pediatric direct laryngoscopy using a three-dimensional endoscopic system

Publication date: Available online 6 July 2018

Source: American Journal of Otolaryngology

Author(s): Oshri Wasserzug, Gad Fishman, Anat Wengier, Yael Oestreicher-Kedem, Ophir Handzel, Dan M. Fliss, Nevo Margalit, Ahmad Safadi, Ari DeRowe

Abstract

Background

Direct laryngoscopy and rigid bronchoscopy are currently performed using 2-dimensional endoscopic systems. Our objective was to determine whether a 3-dimensional endoscopic system can enhance visualization of the surgical field in pediatric direct laryngoscopy and rigid bronchoscopy.

Methods

A prospective cohort study was conducted. Thirty three children who underwent direct laryngoscopies in a tertiary referral children's hospital were enrolled. Direct laryngoscopy was performed using both 2- and 3-dimensional endoscopic systems, after which the surgeons scored the quality of the images obtained with each system on a scale from 1 (low) to 5 (high). Comparison of the scores obtained with the 2 endoscopic systems was performed.

Results

The 33 study children (mean age 2.3 years, M:F ratio 1:1.6) underwent 47 direct laryngoscopies. The mean score for visualization of the glottis was 4.8 for the three-dimensional system compared to 4.0 for the two-dimensional system (P = .025), 4.7 vs. 3.8, respectively, (P = .019) for the subglottis, and 4.6 vs. 3.9, respectively (P = .031) for visualization of the proximal trachea. The mean score for visualization of the distal trachea was 3.0 vs. 3.7, respectively (P = .020). In a child with recurrent type 3 laryngotracheal cleft a residual tracheo-esophageal fistula could not be detected using the 2D system, but was immediately detected using the 3D system.

Conclusions

Visualization of the glottis, subglottis and proximal trachea during direct laryngoscopy using a 3-dimensional endoscopic system was rated by the surgeons as being superior to the conventional 2-dimensional technique. Further outcome studies that will demonstrate the clinical advantage of the 3D technology are highly required.

Level of evidence: 2b.

https://ift.tt/2uaURKA

Sleep study indices and early post-tonsillectomy outcomes

Publication date: Available online 6 July 2018

Source: American Journal of Otolaryngology

Author(s): Daniel C. O'Brien, Yuti Desai, Robert T. Swanson, Uma Parekh, Jane Schubart, Michele M. Carr

Abstract

Objectives

To investigate the relationships between preoperative sleep study findings of children undergoing adenotonsillectomy anesthesia emergence time, recovery room time, and length of stay.

Study design

Retrospective case series with chart review.

Setting

Tertiary care children's hospital.

Subjects and methods

All children aged 1–17 years who had undergone adenotonsillectomy between 2013 and 2016 were included. Apnea-hypopnea index (AHI), central apnea index (CAI), oxygen saturation nadir, and end-tidal carbon dioxide were compared with the in-operating room times, recovery room time, and length of stay.

Results

Three hundred and fourteen patients with a mean age of 6.67 (95% CI 6.25–7.09) years were included. Mean AHI was 9.14 (95% CI 7.33–10.95), mean CI was 0.88 (95% CI 0.50–1.26), mean oxygen saturation nadir was 82.9% (95% CI 81.41–84.32), mean end-tidal carbon dioxide was 50.3 (95% CI 49.39–51.15). Mean emergence time was 16 min (95% CI 15:11–17:13 min), recovery room time was 66 min (95% CI 1:00–1:11 h), and length of stay was 25.7 h (95% CI 21:43–30:00 h).

When controlled for age, gender and BMI, linear regression showed that children with a higher AHI had a significantly longer operating room and operative times (p < 0.001), emergence time (p < 0.001) and length of stay (p = 0.01). CAI was related to shorter total operating room times (p = 0.03). AHI, oxygen saturation nadir, CAI and end-tidal carbon dioxide were not associated with recovery room time.

Conclusion

Preoperative sleep study indices are associated with longer in-operating room times and length of stay, and can be useful in planning operating room and hospital flow.

https://ift.tt/2u02rbx

Impact of long-term androgen deprivation therapy on PSMA ligand PET/CT in patients with castration-sensitive prostate cancer

Abstract

Purpose

Since the introduction of PSMA PET/CT with ⁶⁸Ga-PSMA-11, this modality for imaging prostate cancer (PC) has spread worldwide. Preclinical studies have demonstrated that short-term androgen deprivation therapy (ADT) can significantly increase PSMA expression on PC cells. Additionally, retrospective clinical data in large patient cohorts suggest a positive association between ongoing ADT and a pathological PSMA PET/CT scan. The present evaluation was conducted to further analyse the influence of long-term ADT on PSMA PET/CT findings.

Methods

A retrospective analysis was performed of all 1,704 patients who underwent a ⁶⁸Ga-PSMA-11 PET/CT scan at our institution from 2011 to 2017 to detect PC. Of 306 patients scanned at least twice, 10 had started and continued ADT with a continuous clinical response between the two PSMA PET/CT scans. These ten patients were included in the current analysis which compared the tracer uptake intensity and volume of PC lesions on PSMA PET/CT before and during ongoing ADT.

Results

Overall, 31 PC lesions were visible in all ten patients before initiation of ADT. However, during ongoing ADT (duration 42–369 days, median 230 days), only 14 lesions were visible in eight of the ten patients. The average tracer uptake values decreased in 71% and increased in 12.9% of the PC lesions. Of all lesions, 33.3% were still visible in six patients with a complete PSA response (≤0.1 ng/ml).

Conclusion

Continuous long-term ADT significantly reduces the visibility of castration-sensitive PC on PSMA PET/CT. If the objective is visualization of the maximum possible extent of disease, we recommend referring patients for PSMA PET/CT before starting ADT.

https://ift.tt/2J1G0aN

Probabilistic electrical stimulation mapping of human medial frontal cortex

Publication date: Available online 6 July 2018

Source: Cortex

Author(s): Gianluca Trevisi, Simon B. Eickhoff, Fahmida Chowdhury, Ashwani Jha, Roman Rodionov, Mark Nowell, Anna Miserocchi, Andrew W. McEvoy, Parashkev Nachev, Beate Diehl

Abstract

The medial frontal cortex remains functionally ill-understood; this is reflected by the heterogeneity of behavioural outcomes following damage to the region. We aim to use the rich information provided by extraoperative direct electrical cortical stimulation to enhance our understanding of its functional anatomy.

Examining a cohort of 38 epilepsy patients undergoing direct electrical cortical stimulation in the context of presurgical evaluation, we reviewed stimulation findings and classified them in a behavioural framework (positive motor, negative motor, somatosensory, speech disturbances, and "other"). The spatially discrete cortical stimulation-derived data points were then transformed into continuous probabilistic maps, thereby enabling the voxel-wise spatial inference widely used in the analysis of functional and structural imaging data.

A functional map of stimulation findings of the medial wall emerged. Positive motor responses occurred in 141 stimulations (31.2%), anatomically located on the paracentral lobule (threshold at p<0.05), extending no further than the vertical anterior commissure (VCA) line. Thirty negative motor responses were observed (6.6%), localised to the VCA line (at p<0.001 uncorrected).In 43 stimulations (9.5%) a somatosensory response localised to the caudal cingulate zone (at p<0.001 uncorrected), with a second region posterior to central sulcus. Speech disturbances were elicited in 38 stimulations (8.4%), more commonly but not exclusively from the language fMRI dominant side, just anterior to VCA (p<0.001 uncorrected). In only 2 stimulations, the patient experienced a subjective "urge" to move in the absence of overt movement.

Classifying motor behaviour along the dimensions of effector, and movement vs arrest, we derive a wholly data-driven stimulation map of the medial wall, powered by the largest number of stimulations of the region reported (n=452) in patients imaged with MRI. This model and the underlying data provide a robust framework for understanding the architecture of the region through the joint analysis of disruptive and correlative anatomical maps.

https://ift.tt/2tYIi5O

Ricardo Baroudi: an icon of plastic surgery and a dear friend

https://ift.tt/2KWG8dt

Effect of Sleep Deprivation on Hearing Levels in Rats

Publication date: Available online 6 July 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Jae Hyun Jung, Miryeong Kim, Seung Jae Lee, Eunsang Lee, Se A. Lee, Jong Dae Lee, Ji Ho Choi, Bo Gyung Kim

Abstract

Objectives

To our knowledge, the influence of sleep deprivation on hearing levels has yet to be assessed in animals. Therefore, we evaluated whether auditory function was affected by sleep deprivation in rats.

Methods

Male Wistar rats (aged 9 weeks, weighing 300-400 g) were used for the study and were randomly assigned to a control (n=15) or sleep deprivation group (n=12). Hearing levels were evaluated at baseline and 9 days after sleep deprivation using auditory evoked brainstem responses (ABRs) and distortion product otoacoustic emission (DPOAE) measurements. Blood was collected for the measurement of interleukin-1β and corticosterone levels.

Results

The ABR thresholds (at 8, 16, and 32 kHz) at 9 days were significantly elevated in the sleep deprivation group compared to the control group (p<0.05, respectively). The sleep deprivation group showed a defect in the function of outer hair cells, as evidenced by decreased levels of distortion product otoacoustic emission. IL-1β was significantly increased in the sleep deprivation group. Sleep-deprived rats exhibited rupture of Reissner's membrane and morphological damage to stereocilia.

Conclusion

These results suggest that sleep deprivation induces damage to the cochlea and results in hearing loss in Wistar rats.

https://ift.tt/2KHT62Q

The Wound Healing Capacity Of Undifferentiated And Differentiated Airway Epithelial Cells In Vitro

Publication date: Available online 6 July 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Cynthia M. Schwartz, Braedyn A. Dorn, Selam Habtemariam, Cynthia L. Hill, Tendy Chiang, Susan D. Reynolds

Abstract

Introduction

Congenital or acquired tracheal lesions alter airway epithelial structure and can lead to long-segment tracheal defects. Tissue engineered tracheal grafts (TETG) have the potential to cure such defects; however, clinical applications have been plagued with numerous complications including delayed graft epithelialization. The knowledge that epithelial cells migrate from native tissue to the TETG raises the possibility that TETG performance can be improved by increasing the rate of epithelialization.

Objectives

We developed a model that can be used quantify epithelial migration in clinically-relevant conditions.

Methods

Existing histological analyses determined the differentiation status of the normal and injured human tracheal epithelium and were used to identify in vitro culture conditions that mimic these parameters. The classical scratch assay was adapted to permit analysis of migratory velocity as a function of differentiation status. Migration of undifferentiated (UD), partially-differentiated (PD), and well-differentiated (WD) epithelia was quantified.

Results

The normal and injured epithelium can be modeled using human cells that are cultured using a modified air-liquid-interface culture system. PD cell cultures are similar to the remodeled epithelium; whereas; WD cultures are similar to the normal epithelium. Preliminary results indicate that PD cells migrate more rapidly than WD cells and that PD and WD cells migrate more rapidly than UD cells.

Conclusion

Pending verification of these results, we suggest that epithelial migration is significantly altered by differentiation status. Thus, efforts to improve TETG epithelialization should use model systems that faithfully-represent the differentiation state of the native tissue.

https://ift.tt/2MSMhIe

JSID's Fellowship Shiseido Research Grant

Publication date: August 2018

Source: Journal of Dermatological Science, Volume 91, Issue 2

Author(s):

https://ift.tt/2KVVv5R

The Editor's Choice

Publication date: August 2018

Source: Journal of Dermatological Science, Volume 91, Issue 2

Author(s):

https://ift.tt/2NwQfXX

Editorial board

Publication date: August 2018

Source: Journal of Dermatological Science, Volume 91, Issue 2

Author(s):

https://ift.tt/2J5788K

Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense

Jörn Coers | Hailey M Brown | Seungmin Hwang | Gregory A Taylor

https://ift.tt/2u0MamW

Contemporary considerations in concurrent endoscopic sinus surgery and rhinoplasty

Purpose of review Characterize indications, perioperative considerations, clinical outcomes and complications for concurrent endoscopic sinus surgery (ESS) and rhinoplasty. Recent findings Chronic rhinosinusitis and septal deviation with or without inferior turbinate hypertrophy independently impair patient-reported quality of life. Guidelines implore surgeons to include endoscopy to accurately evaluate patient symptoms. Complication rates parallel those of either surgery (ESS and rhinoplasty) alone and are not increased when performed concurrently. Operative time is generally longer for joint surgeries. Patient satisfaction rates are high. Summary Concurrent functional and/or cosmetic rhinoplasty and ESS is a safe endeavor to perform in a single operative setting and most outcomes data suggest excellent patient outcomes. Additional studies that include patient-reported outcome measures are needed.

https://ift.tt/2J0SuzA

Editorial introductions

No abstract available

https://ift.tt/2KS76WN

Management of obstructive sleep apnoea: an update on the role of distraction osteogenesis

Purpose of review This article reviews the current literature on the use of distraction osteogenesis as a treatment for patients with obstructive sleep apnoea (OSA). We reviewed the indications, surgical protocols and outcomes for distraction osteogenesis in paediatric and adult OSA cases described in the literature. Recent findings There is evidence that distraction osteogenesis is effective in treating children with OSA as a result of underdevelopment of jaws such as those with craniofacial syndromes. Distraction osteogenesis appears to be the only available treatment that prevents tracheostomy in some of these cases, or allows decannulation after distraction. For adult OSA patients, distraction osteogenesis is reported to be reserved for challenging cases such as OSA as a consequence of temporomandibular joint ankylosis. It is used where conventional orthognathic surgery is not feasible. The studies reported high success rate/cure rate of OSA after distraction osteogenesis. Technological advances such as three-dimensional printing assist the execution of an accurate distraction process. Summary Distraction osteogenesis appears to be an effective treatment for paediatric OSA patients with craniofacial anomalies, and is used in selected cases of adult with severe OSA. With the improvement in distraction device designs and computer technology, distraction osteogenesis may play a bigger role in the treatment of OSA.

https://ift.tt/2J1yE7b

Update on complications in cleft orthognathic surgery

Purpose of review To give an update on recent publications and tendencies concerning complications in cleft orthognathic surgery. Recent findings Cleft-specific changes after orthognathic surgery and their impact on surgical outcomes are discussed. Focus lays on the causes and mechanisms of cleft-related surgical complications and strategies to prevent or minimize these complications. Bimaxillary surgery is seen as a safe procedure for cleft patients. Maxillary distraction, total or segmental, is pointed out as an alternative method to improve outcomes. Different techniques for osteotomies and maxillary mobilization could decrease adverse events. Summary Cleft patients are more susceptible to the occurrence of complications because of peculiar presurgical conditions. Different surgical approaches and techniques are presented to overcome these difficulties, to achieve better results and to increase patient safety. The importance of communication between patient, family and cleft team members is emphasized.

https://ift.tt/2NwMRMJ

Blepharoptosis repair

Purpose of review To review recent advances on the mechanisms and management of acquired aponeurotic blepharoptosis. Recent findings Recent advances over the past year have focused on refining well known methods of ptosis repair, expanding and modifying techniques to treat difficult and more severe conditions, and uncovering the biomechanical and neurostimulatory mechanisms of ptosis and its repair. Summary Innovations in ptosis repair are discussed in the context of current treatment paradigms.

https://ift.tt/2KVE5Xd

Antibiotic use in facial plastic surgery

Purpose of review The aim of this study was to review and discuss recent literature regarding perioperative use of antibiotics in the context of facial plastic surgery. Recent findings Despite research efforts, there continues to be insufficient evidence in support of, or against, the use of antimicrobial prophylaxis. Summary Current available evidence regarding antibiotic use in facial plastic surgery procedures fails to demonstrate routine benefit. Therefore, the advantages accompanying administration of preoperative antibiotics should be weighed against any potential complications on a case-by-case basis. Future large-scale prospective studies will be beneficial in developing standardized criteria directing appropriate antibiotic use.

https://ift.tt/2KW15Iy

Improving aesthetic outcomes after head and neck reconstruction

Purpose of review Tremendous advancements have been made in head and neck reconstruction following oncologic resection. Despite this, many patients are left with disfiguring postoperative changes. The focus of this review highlights various techniques aimed at improving aesthetic outcomes following head and neck cancer therapy, with a focus on liposuction and fat augmentation. Recent findings Over the past decade, the use of liposuction in treating lymphedema after head and neck cancer therapy has showed promising results. Owing to great improvements in harvesting and purification techniques, fat augmentation has been effectively utilized in correcting a wide array of defects. Although free tissue transfer is frequently used in head and neck reconstruction, there is a scarcity of literature on the indications for flap revision procedures. Summary Head and neck reconstructive surgery can lead to significant cosmetic and functional morbidity. Several tools are available to help improve aesthetic outcomes in this patient population. A thorough understanding of the various techniques and their indications is essential for achieving optimal results. Video abstract available: See the Video Supplementary Digital Content 1, https://ift.tt/2IcL93h

https://ift.tt/2KUrmny

Modern management of osteoradionecrosis

Purpose of review Despite recent advances in radiotherapy, osteoradionecrosis (ORN) remains a common and difficult complication of radiation therapy in head and neck cancer patients. Available treatment options are complementary to its complex pathophysiology and the currently available theories of ORN development. The efficacy of hyperbaric oxygen therapy has recently been questioned, and therapies targeting the fibroatrophic process have become a focus of ORN treatment. The objective of this review is to evaluate the literature regarding ORN of the mandible, with a focus on available treatment options. Recent findings The recently proposed fibroatrophic theory has challenged the traditional hypovascular-hypoxic-hypocellular theory as the mechanism of ORN. Medical management targeting this fibroatrophic process offers promising results, but has yet to be confirmed with robust clinical trials. The routine use of hyperbaric oxygen therapy is not substantiated in the literature, but may be justified for select patients. Systemic steroids may also have a role, though data are limited. Summary The fibroatrophic process has gained acceptance as a main mechanism of ORN. No gold standard treatment or consensus guidelines exist, though a combination of therapeutic strategies should be considered, taking into account the severity of disease and individual patient characteristics.

https://ift.tt/2KZ5VS4

Multidisciplinary management of oculo-auriculo-vertebral spectrum

Purpose of review Oculo-auriculo-vertebral spectrum (OAVS) is a complex disorder that is represented by wide variations in phenotypic presentation. Recent publications and systematic reviews of the available literature are presented here. Recent findings Treatment strategies vary among craniofacial centers across the country. Advances in presurgical planning, virtual surgical planning, and computer-aided manufacturing have been incorporated in the treatment of patients. The psychosocial effect of OAVS with longitudinal follow-up is now being studied. Summary Optimal evaluation and management of the OAVS patient requires an awareness of the phenotypic and genetic differences and involves a multidisciplinary team in order to effectively and appropriately diagnose and treat such patients.

https://ift.tt/2NAf5qa

Blood loss mitigation and replacement in facial surgery: a review

Purpose of review To provide a comprehensive overview of the predisposing factors that contribute to a risk of excess bleeding for surgical therapy in the head and neck regions, provide a thorough overview of techniques and tools for managing blood loss complications, and provide intervention algorithms to help guide clinical decision making. Recent findings With the current landscape of medications and reversal agents, protocols for intervention in a variety of situations, and new tools for blood loss management all rapidly changing and being developed it is critical to stay up to date to provide patients the best care in the most critical of situations. Summary With the risk of blood loss complications in head and neck surgery ranging from minimal to extreme surgeons require a comprehensive understanding risk factors, patient evaluation tools, and proper management algorithms. The first opportunity to prevent unnecessary blood loss and blood loss complications is the health history and physical appointment where a clinician can identify any medications, conditions, or other predisposing factors that would elevate a patient's risk of excess bleeding and the necessity for treatment augmentation. Although not all complications can be prevented because of the natural physiological variation that occurs from patient to patient, despite proper and proper diagnostics, a full working knowledge of most likely complications, hemostatic tools, and concise communication with team members can prevent a lot of blood loss and the complications associated.

https://ift.tt/2J0wfJO

Acute catatonia on medical wards: a case series

Catatonia is a behavioral syndrome which presents with an inability to move normally. It is associated with mood disorders and schizophrenia, as well as with medical and neurological conditions. It is an expre...

https://ift.tt/2KUsJT7

Symptomatic bilateral pulmonary embolism without deep venous thrombosis in an adolescent following arthroscopic anterior cruciate ligament reconstruction: a case report and review of the literature

Venous thromboembolism, specifically pulmonary embolism, is a rare complication following elective pediatric orthopedic surgery. Bilateral pulmonary embolism with associated pulmonary hemorrhage/infarct withou...

https://ift.tt/2KPuLas

Appreciating the Intricacies of a Stuffy Nose

Common conditions occur commonly, but identifying the causes and optimizing treatment may be difficult. Nasal airway obstruction, one of the most common complaints related to Otolaryngology, is often reported to health care providers in various fields. These include pediatrics, family practice, internal medicine, geriatrics, obstetrics/gynecology, emergency medicine, and, of course, otolaryngology. Anyone who's spent a sleepless night due to a blocked nose or had difficulty speaking during the day or managing the secondary dry mouth/throat that comes with a significantly obstructed nasal cavity can appreciate the dramatic reduction in quality of life that results from this chronic condition.

https://ift.tt/2m0rMht

Omalizumab in chronic spontaneous urticaria: a real-life experience of dose and intervals adjustments in Belgium

Omalizumab was clearly shown to be effective and safe for treating refractory chronic spontaneous urticaria (CSU) not adequately controlled with H1-antihistamines (anti-H1). Supported by data of five randomized, placebo-controlled clinical trials,1 the recommended regimen is 300mg every four weeks, 38.1%/55.1% of patients being respectively completely/partially free of urticaria after 12 weeks with this regimen.

https://ift.tt/2NtyuJ7

Intraperitoneal sodium metavanadate exposure induced severe clinicopathological alterations, hepato-renal toxicity and cytogenotoxicity in African giant rats ( Cricetomys gambianus , Waterhouse, 1840)

Abstract

Pollution of environment due to increased exploitation of minerals has been on the rise, and vanadium, a metal in the first transition series essential for mammalian existence, is a major component of air pollution. This study investigated the clinico-pathological, hepato-renal toxicity, and cytogenotoxicity of intraperitoneal exposure of African giant rats (AGRs), a proposed model for ecotoxicological research to sodium metavanadate. A total of 27 adult male African giant rats weighing 975 ± 54.10 g were distributed into two major groups: sodium metavanadate (SMV) treated and control. They were observed daily for clinical signs of toxicity. Four rats from each group were randomly collected and sacrificed after 3, 7, and 14 days of SMV treatment. Liver, kidney, and bone marrow were analyzed for histopathology and micronucleated normochromated and polychromated erythrocytes (MNNCE and MNPCE), respectively. Clinical signs in treated AGR include sluggish and weak movements, un-groomed fur, and labored breathing. Histology of the kidney revealed severe glomerular atrophy, tubular ectasia, and vacuolar degeneration of tubular epithelium, while liver histology showed sinusoidal congestion and severe hepatocellular necrosis after 14 days SMV exposure. Also, MNNCE and MNPCE significantly increased with a decrease in PCE/NCE ratio in SMV-treated AGR, suggestive of alternations in bone marrow cell proliferation. Hence, SMV treatment to AGR resulted to severe clinicopathologic alterations, kidney, and liver dysfunction and cytogenotoxicity evident by somatic mutation induction which could be severe with prolonged exposure. This suggests African giant rat as an ecotoxicological model to measure major health risks to animals and human populations in highly polluted environment.

https://ift.tt/2MXI8mu

Enhanced visualization of the surgical field in pediatric direct laryngoscopy using a three-dimensional endoscopic system

Direct laryngoscopy and rigid bronchoscopy are currently performed using 2-dimensional endoscopic systems. Our objective was to determine whether a 3-dimensional endoscopic system can enhance visualization of the surgical field in pediatric direct laryngoscopy and rigid bronchoscopy.

https://ift.tt/2lXnt6h

Sleep study indices and early post-tonsillectomy outcomes

To investigate the relationships between preoperative sleep study findings of children undergoing adenotonsillectomy anesthesia emergence time, recovery room time, and length of stay.

https://ift.tt/2zrqSUP

The role of the otolaryngologist in the evaluation and management of headaches

Headaches are commonly evaluated in otolaryngology and often represent a diagnostic dilemma. This review addresses rhinogenic headache as well as trigeminal neuralgia and migraine, both of which can masquerade as sinus headache and whose management increasingly involves otolaryngology intervention. Discussion considers diagnostic criteria and novel therapies and derives an algorithm for clinical decision-making.

https://ift.tt/2lYgk5O

Status, sources and contamination levels of organochlorine pesticide residues in urban and agricultural areas: a preliminary review in central–southern Italian soils

Abstract

Organochlorine pesticides (OCPs) are synthetic chemicals commonly used in agricultural activities to kill pests and are persistent organic pollutants (POPs). They can be detected in different environmental media, but soil is considered an important reservoir due to its retention capacity. Many different types of OCPs exist, which can have different origins and pathways in the environment. It is therefore important to study their distribution and behaviour in the environment, starting to build a picture of the potential human health risk in different contexts. This study aimed at investigating the regional distribution, possible sources and contamination levels of 24 OCP compounds in urban and rural soils from central and southern Italy. One hundred and forty-eight topsoil samples (0–20 cm top layer) from 78 urban and 70 rural areas in 11 administrative regions were collected and analysed by gas chromatography–electron capture detector (GC–ECD). Total OCP residues in soils ranged from nd (no detected) to 1043 ng/g with a mean of 29.91 ng/g and from nd to 1914 ng/g with a mean of 60.16 ng/g in urban and rural area, respectively. Endosulfan was the prevailing OCP in urban areas, followed by DDTs, Drins, Methoxychlor, HCHs, Chlordane-related compounds and HCB. In rural areas, the order of concentrations was Drins > DDTs > Methoxychlor > Endosulfans > HCHs > Chlordanes > HCB. Diagnostic ratios and robust multivariate analyses revealed that DDT in soils could be related to historical application, whilst (illegal) use of technical DDT or dicofol may still occur in some urban areas. HCH residues could be related to both historical use and recent application, whilst there was evidence that modest (yet significant) application of commercial technical HCH may still be happening in urban areas. Drins and Chlordane compounds appeared to be mostly related to historical application, whilst Endosulfan presented a complex mix of results, indicating mainly historical origin in rural areas as well as potential recent applications on urban areas. Contamination levels were quantified by Soil Quality Index (SoQI), identifying high levels in rural areas of Campania and Apulia, possibly due to the intensive nature of some agricultural practices in those regions (e.g., vineyards and olive plantations). The results from this study (which is in progress in the remaining regions of Italy) will provide an invaluable baseline for OCP distribution in Italy and a powerful argument for follow-up studies in contaminated areas. It is also hoped that similar studies will eventually constitute enough evidence to push towards an institutional response for more adequate regulation as well as a full ratification of the Stockholm Convention.

https://ift.tt/2IZIczE

Branchial Cyst with Branchial Fistula: A Rare Association

Abstract

Branchial arch anomalies are the most common congenital neck masses. The second branchial arch anomalies followed by first arch anomalies are seen commonly in the descending order. They originate from remnants of branchial arches and clefts. They may present as cysts, sinus tracts, fistulae or cartilaginous remnants. They are mostly located in the lateral aspect of the neck anterior to the sternocleidomastoid, anterior to the hyoid bone, preauricular region or at the angle of the mandible. A complete fistula communicating with a branchial arch cyst is a very rare congenital anomaly of the branchial apparatus. These patients are generally asymptomatic but may present with mucoid discharge from the tract. Here we present a case of branchial fistula associated with a branchial cyst in a 11 year old child.

https://ift.tt/2KVNnSM

Sutureless Tragal Cartilage Island Tympanoplasty: Our Experience

Abstract

To evaluate graft take up and hearing improvement using the technique of tragal cartilage island in COM-mucosal type. Prospective study. A total of 258 type 1 tympanoplasty surgeries were done using tragal cartilage island graft from December 2013, to December 2015; in Jubilee Mission Medical College and Research Institute with a follow up of 1 year. Inclusion criteria—all the patients undergoing type 1 tympanoplasty for chronic otitis media (mucosal type, inactive) with an intact ossicular chain by the senior author. The youngest patient was 6 years old and the oldest was 64 years. This pattern was selected for getting a uniform pattern even though cartilage tympanoplasty can be done in other forms of COM also. Graft take up in our study was found to be 96.12% in 1 year of follow up. Closure of tympanic membrane was achieved in 248 of 258 cases. None of the patients showed retraction pockets or cholesteatoma during follow up. The average pre-op AB gap was 21.62 dB which was lowered to 4.22 dB post op. The mean gain in hearing was 17.37 dB. It is worthwhile to consider tragal cartilage island graft as an alternative to temporalis fascia.

https://ift.tt/2NulEKV

Ivermectin: A Novel Method of Treatment of Nasal and Nasopharyngeal Myiasis

Abstract

To evaluate the efficacy of oral Ivermectin, in patients suffering from nasal and nasopharyngeal myiasis. This was a prospective study, comprising 80 patients of nasal and nasopharyngeal myiasis. Patients underwent clinical examination and nasal endoscopy at the time of presentation and findings were recorded. The patients were randomly divided in two groups. In group-I the patients underwent manual extraction of the maggots after instillation of chloroform and turpentine oil mixture, whereas the group-II patients underwent manual extraction with administration of two doses (24 h apart) of oral Ivermectin (6 mg each). The patients were instructed to record the time when they noticed shedding of maggots, and evaluated for the clearance of maggots by endoscopy after 24, 48 h and 7 days after the initial examination. The mean maggot shedding time (by t test) in Group-I was 41.23 ± 4.23 h and in Group-II was 24.60 ± 3.15 h. The difference being highly significant statistically, (p = 0.0001). The endoscopic clearance of maggots (by Chi square test) between the two group of patients was also statistically significant at 24 and 48 h with p value of (p = 0.002) and (p = 0.006) respectively. Oral Ivermectin was effective in treating nasal and nasopharyngeal myiasis, in terms of early clearance, decreased morbidity and less hospital stay. We conclude that oral Ivermectin can be used as a safe and effective method for the treatment of nasal & nasopharyngeal myiasis.

https://ift.tt/2KTlHhk

Vallecular Neurofibroma Successfully Managed with Endoscopic Assisted Coblation: A Novel Technique

Abstract

Although solitary neurofibroma can affect the various subsites of the head and neck region, oropharyngeal neurofibroma is very rare and total five cases (four in the soft palate and one in the palatine tonsil) have been reported. Here we present a 42-year old female patient presented to the out patient department with respiratory obstruction and voice change for 3 months. Complete excision of the mass was achieved by endoscopic coablation and which was confirmed to be a neurofibroma.

https://ift.tt/2KT8gRO

Omalizumab in chronic spontaneous urticaria: a real-life experience of dose and intervals adjustments in Belgium

Publication date: Available online 6 July 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): de Montjoye Laurence, Herman Anne, Dumoutier Laure, Lambert Michel, Tromme Isabelle, Baeck Marie

https://ift.tt/2lXpa3N

FDA-approved peanut allergy treatment: the first wave is about to crest

Publication date: Available online 6 July 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Stephen A. Tilles, Daniel Petroni

https://ift.tt/2ucN1QD

Rosmarinic acid affects immunological and inflammatory mediator levels and restores lung pathological features in asthmatic rats

Publication date: Available online 6 July 2018

Source: Allergologia et Immunopathologia

Author(s): F. Shakeri, N. Eftekhar, N. Mohammadian Roshan, R. Rezaee, A. Moghimi, M.H. Boskabady

Abstract

Background

The effects of rosmarinic acid (RA) on immunological and inflammatory mediator levels in bronchoalveolar lavage fluid (BALF) as well as lung pathological changes in asthmatic rats were investigated.

Methods

The levels of IFN-γ, IL-4, IFN-γ/IL-4 ratio, IgE, PLA₂, and total protein (TP) in BALF and pathological changes in the lung were evaluated in control group (C), asthma group (sensitized to ovalbumin) (A), asthma groups treated with RA and dexamethasone.

Results

Compared to the control group, asthmatic rats showed increased levels of IL-4, IgE, PLA2, and TP as well as all pathological scores with decreased levels of IFN-γ and IFN-γ/IL-4 ratio (P < 0.05 to P < 0.001). The levels of IL-4, IgE, PLA₂, and TP significantly reduced in groups treated with all concentrations of RA compared to asthma group (P < 0.001 for all cases). IFN-γ was significantly decreased in groups treated with two lower concentrations of RA but IFN-γ/IL-4 ratio was increased in groups treated with two higher concentrations of RA compared to asthma group (P < 0.05 to P < 0.001). Treatment with all doses of RA led to significant improvement in pathological scores in asthmatic animals (P < 0.05 to P < 0.001). Most measured parameters were also significantly improved in dexamethasone-treated animals (P < 0.01 to P < 0.001) but IFN-γ/IL-4 ratio and the scores of interstitial fibrosis, bleeding and epithelial damage did not change in this group.

Conclusion

The results indicated a preventive effect for RA on immunological and inflammatory mediators as well as lung pathological changes in asthmatic rats which were comparable or even more potent than that of dexamethasone.

https://ift.tt/2lYIZHN

What do we know about cancer immunotherapy? Long-term survival and immune-related adverse events

Publication date: Available online 6 July 2018

Source: Allergologia et Immunopathologia

Author(s): Jesus Miranda Poma, Lorena Ostios Garcia, Julia Villamayor Sanchez, Gabriele D'errico

Abstract

Immunotherapy delivered a new therapeutic option to the oncologist: Ipilimumab (anti-CTLA-4), Nivolumab and Pembrolizumab (anti-PD1), and Atezolizumab (anti-PD-L1) increase overall survival and show a better safety profile compared to chemotherapy in patients with metastatic melanoma, lung, renal cancer among others. But all that glitters is not gold and there is an increasing number of reports of adverse effects while using immune-checkpoint inhibitors. While chemotherapy could weaken the immune system, this novel immunotherapy could hyper-activate it, resulting in a unique and distinct spectrum of adverse events, called immune-related adverse events (IRAEs). IRAEs, ranging from mild to potentially life-threatening events, can involve many systems, and their management is radically different from that of cytotoxic drugs: immunosuppressive treatments, such as corticoids, infliximab or mycophenolate mofetil, usually result in complete reversibility, but failing to do so can lead to severe toxicity or even death. Patient selection is an indirect way to reduce adverse events minimizing the number of subjects exposed to this drugs: unfortunately PDL-1, the actual predictive biomarker, would not allow clinicians select or exclude patients for treatment with checkpoint inhibitors.

https://ift.tt/2zi9NMF

Novel Bacillus cereus strain from electrokinetically remediated saline soil towards the remediation of crude oil

Abstract

A new strain SWH-15 was successfully isolated after initial electrokinetic remediation experiment using the same saline soil sampled from Shengli Oilfield, China. Four methods (morphological and biochemical characteristics, whole-cell fatty acid methyl esters (FAMEs) analysis, 16S rRNA sequence analysis and DNA G + C content and DNA–DNA hybridization analysis) were used to identify the taxonomic status of SWH-15 and confirmed that SWH-15 was a novel species of the Bacillus (B.) cereus group. Then, we assessed the degrading ability of the novel strain SWH-15 to crude oil through a microcosm experiment with four treatments, including control (CK), bioremediation using SWH-15 (Bio), electrokinetic remediation (EK), and combined bioremediation and electrokinetic remediation (Bio + EK). The results showed that the Bio + EK combined remediation treatment was more effective than the CK, Bio, and EK treatments in degrading crude oil contaminants. Bioaugmentation, by addition of the strain SWH-15 had synergistic effect with EK in Bio + EK treatment. Bacterial community analysis showed that electrokinetic remediation alone significantly altered the bacterial community of the saline soil. The addition of the strain SWH-15 alone had a weak effect on the bacterial community. However, the strain SWH-15 boosted the growth of other bacterial species in the metabolic network and weakened the impact of electrical field on the whole bacterial community structure in the Bio + EK treatment.

https://ift.tt/2uaIy13

Inflammatory immune response in rabbits with Staphylococcus aureus biofilm–associated sinusitis

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2Nxu97S

A multi‐institutional review of outcomes in biopsy‐proven acute invasive fungal sinusitis

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2IZl5Fp

Total intravenous anesthesia improves intraoperative visualization during surgery for high‐grade chronic rhinosinusitis: a double‐blind randomized controlled trial

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2KRsviR

Incorporation of antibiotics and systemic steroids by sinus surgeons: is there widespread consensus?

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2IZkWBR

The lamina push test: an alternative to the globe push test for identifying the medial orbit during endoscopic sinus surgery

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2KOKMgO

Association between allergic rhinitis and poor sleep parameters in U.S. adults

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2J4A0OI

The effect of urban particulate matter on cultured human nasal fibroblasts

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2NuNaYo

Comparative study of the effect of Er:YAG and Er:Cr;YSGG lasers on porcelain: etching for the bonding of orthodontic brackets

Abstract

This study investigated the effect of Er:YAG (smart 2940 Dplus, DEKA, Italy) and Er:CrYSGG (Waterlase iPlus, Biolase, USA) lasers on the shear bond strength (SBS) between the orthodontic brackets and dental porcelain in comparison with conventional acid etching with 9% hydrofluoric acid (HF, Ultradent, USA). A total of 60 specimens of maxillary incisor crown were prepared and randomly assigned to five groups; each group was subjected to a different porcelain surface conditioning: (1) etching with the 9% HF for 2 min; (2) etching with the 9% HF for 2 min followed by irradiation with the Er:CrYSGG laser (3-W power, 10-Hz frequency for 10 s); (3) etching with the 9% HF for 2 min followed by irradiation with the Er:YAG laser (3-W power, 10-Hz frequency for 10 s); (4) Irradiation with the Er:CrYSGG laser (3-W power, 10-Hz frequency for 10 s without acid etching) and (5) irradiation with the Er:YAG laser (3-W power,10-Hz frequency for 10 s without acid etching). After using Transbond XT primer and Transbond XT adhesive, the metal brackets (Dentaurum, Germany equilibrium 2, optimal design) bonded to the conditioned porcelain surface. Subsequently, the specimens were thermocycled for 5000 cycles and then debonded using the Universal Testing Machine (Zwick). In each group, one specimen was not bonded to brackets to allow further examination with electron microscopy. After debonding, the specimens were examined by stereomicroscope to determine their adhesive remnant index (ARI). The average SBS [Mean (SD)] values in the five groups were as follows: HF (32.58 ± 9.21 MPa), Er:CrYSGG + HF (27.81 ± 7.66 MPa), Er:YAG + HF (23.08 ± 9.55 MPa), Er:CrYSGG (14.11 ± 9.35 MPa), and Er:YAG (6.30 ± 3.09 MPa). A statistically significant difference in SBS existed between the first three groups and the two laser groups (df = 4, F = 18.555, p < 0.001). Evaluation of ARI values showed that bond failures in the first three groups were mostly of cohesive and mixed types, but in the laser groups, they were mostly adhesive. Chi-square was not significant between groups (p = 0.219). The Er:YAG laser with the stated specifications is not a suitable alternative to HF etching. In the case of Er:CrYSGG laser, although the conditioning outcome met the bond strength requirement for orthodontic brackets (that is, 6–8 MPa). Therefore, the bond strength must be further improved by fine-tuning the irradiation details.

https://ift.tt/2zhnBqX

Effectiveness of low concentration of sodium hypochlorite activated by Er,Cr:YSGG laser against Enterococcus faecalis biofilm

Abstract

Bacteria living in biofilms exhibit altered growth phenotypes, while the biofilm provides benefits, the foremost of which is a certain protection against both immune system and killing effect by antimicrobials. Laser-activated irrigation (LAI) and passive ultrasonic irrigation (PUI) have been proposed as alternative methods for cleaning and disinfecting the root canal, as an adjuvant to conventional chemo-mechanical preparation in order to improve debridement and disinfection. Nevertheless, the potential antibacterial effect of LAI using 0.5% of sodium hypochlorite (NaOCl) has received little attention. Glass Pasteur pipettes were used to mimic single-tooth root canal and to build Enterococcus faecalis biofilm. Several irrigants and treatments were assayed for 60 s including (I) Saline, (II) NaOCl 0.5%, (III) NaOCl 5%, (IV) Er,Cr:YSGG, (V) Saline + LAI, (VI) NaOCl 0.5% + LAI, (VII) Saline + PUI, and (VIII) NaOCl 0.5% + PUI. Bacterial reduction was measured by counting the colony-forming units (CFUs). Additionally, AFM visualization and measurement of nano-roughness parameters were used to evaluate LAI effect on bacteria. NaOCl 5% unpowered and NaOCl 0.5% + LAI were capable of eliminating all bacteria, whereas non-activated saline solution and NaOCl 0.5% failed to eliminate E. faecalis. Lower efficiencies were achieved by PUI. Surface analysis by AFM revealed apparent alterations in NaOCl + LAI-treated cells. The Er,Cr:YSGG laser-activated irrigation (LAI) increased the bactericidal efficiency of 0.5% NaOCl against E. faecalis biofilm.

https://ift.tt/2KSu7sO

Effects of pasireotide treatment on coagulative profile: a prospective study in patients with Cushing’s disease

Abstract

Introduction

Cushing's disease (CD) is characterized by procoagulative profile. Treatment with cortisol-reducing medications might normalize the coagulation impairment potentially eliminating the risk of thromboembolic complications.

Aim

The aim of this prospective study is to evaluate the effectiveness of 6–12 months of treatment with pasireotide (Signifor®, Novartis) 600 µg twice daily on coagulative factors in 21 patients (16 females, mean age 46 ± 12.2 years) with CD. Biochemical, hormonal (urinary free cortisol, UFC; late night salivary cortisol, LNSC; ACTH) and coagulative parameters as Protrombin time (PT), aPTT, factors VIII, IX and XI, antithrombin III, protein C, protein S, fibrinogen, were evaluated at baseline and during therapy.

Results

UFC showed a significant reduction from baseline (3.2 ± 1.8 vs. 1.0 ± 0.8, p < 0.0001) with normalization in 13/21 (61.9%) and in 7/16 (43.8%) at 6 and 12 months, respectively. On the same way LNSC returned to normal in 5/11 at 6 months, showing a trend to reduction (8.6 ± 5 vs. 4.1 ± 2.9), even though without statistical significance (p = 0.07). Throughout the treatment period there was an increase in serum glycaemia (5.5 ± 2.3 vs. 6.8 ± 2.3 mmol/L, p = 0.09), with a concomitant significant increase in HbA1c after 6 months (40.7 ± 8.4 vs. 50.7 ± 12.3 mmol/mol, p = 0.006). Regarding coagulative parameters, no differences were found neither in clotting nor in anticoagulant factors during therapy. No patients developed thrombotic complication during treatment.

Conclusions

Pasireotide resulted an effective treatment in controlling hypercortisolism in more than half of CD patients with partial restoration also of circadian cortisol secretion. No significant improvements were observed on clotting factors; this fact might depend on persistence of typical alteration of CD, such as obesity and hypertension, and reflects also on the worsening in glucide metabolism induced by the drug. Clinical implications of persistent procoagulative impairment while on medical therapy should be considered.

https://ift.tt/2tYDDRq

Waiting List Mortality and Transplant Rates for NASH Cirrhosis When Compared to Cryptogenic, Alcoholic or AIH Cirrhosis

Background Patients with NASH cirrhosis have excellent post liver transplant (LT) survival despite having many co-morbidities. We hypothesized that this could be due to a selection bias. Methods We analyzed the UNOS data from 2002 to 2016 and compared post-LT survival of NASH (n=7,935) patients with cryptogenic (CC, n= 6,087), alcoholic AC, n=16,810) and autoimmune hepatitis (AIH, n= 2,734) cirrhosis. Results By 3 years of listing, the cumulative incidence (CI) of death or deterioration was 29% for NASH, 28% for CC and AC, and 24% for AIH, but when adjusted for risk factors, the CI was similar for NASH and AIH. The factors that increased the risk of waiting list removal due to death/deterioration were poor performance status, encephalopathy, diabetes, high MELD, Hispanic race, older age and a low serum albumin. Most patients were transplanted within the first year [median 2 months (1-7 IQR] of listing and by 5 years, the unadjusted CI of transplantation was 54% for NASH, 52% for CC, 51% for AIH and 48% for AC. The adjusted CI of transplantation within 2 months of listing was higher for AC (SHR 1.17), AIH (SHR 1.17) and CC (SHR 1.13) when compared to NASH, but after 2 months adjusted transplantation rates decreased in AC (SHR =0.6), AIH (0.78) and CC (SHR 0.95). The negative predictors of receiving a transplant were dialysis, female gender, non-White race, high albumin and creatinine. Conclusions Patients with NASH cirrhosis are not disadvantaged by higher waitlist removal or lower transplantation rates. Address for correspondence: Paul J. Thuluvath, MD, FAASLD, FRCP, Institute of Digestive Health & Liver Diseases, Mercy Medical Center, Baltimore, MD 21202. Tel: 410 332 9308; Fax: 410 659 1178; Email: thuluvath@gmail.com Conflicts of interest: None; Financial support: None Contributions: PJT and SH contributed to the idea, YS did the statistical analysis, PJT wrote the manuscript, SH and YS reviewed the final manuscript Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2IZP7Zo

To Investigate the Molecular Mechanism of Traditional Chinese Medicine Constitution Using Next-generation Sequencing in Nasopharyngeal Carcinoma

Condition:   Nasopharyngeal Carcinoma
Interventions:   Drug: Danggui Buxue Tang;   Drug: Placebo
Sponsor:   China Medical University Hospital
Recruiting

https://ift.tt/2KVgoS9

Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy

Conditions:   Salivary Gland Dysfunction;   Xerostomia;   Head and Neck Cancer
Interventions:   Drug: Everolimus;   Other: Laboratory Biomarker Analysis;   Other: Survey Administration
Sponsors:   University of Arizona;   National Cancer Institute (NCI)
Recruiting

https://ift.tt/2MVsmbN

Contrast-Enhanced Ultrasound Identification of Sentinel Nodes in Esophageal Cancer

Condition:   Esophagus
Interventions:   Procedure: Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA);   Procedure: Contrast-Enhanced Ultrasound;   Procedure: Fine-Needle Aspiration;   Drug: Sonazoid (Perflubutane)
Sponsors:   Sidney Kimmel Cancer Center at Thomas Jefferson University;   National Cancer Institute (NCI)
Not yet recruiting

https://ift.tt/2KEY6ow

Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer

Conditions:   Esophageal Neoplasms;   Squamous Cell Carcinoma;   Concurrent Chemoradiotherapy
Interventions:   Drug: Paclitaxel;   Drug: Cisplatin;   Drug: Fluorouracil;   Radiation: chemoradiotherapy;   Procedure: Ivor Lewis esophagogastrectomy
Sponsor:   Mona Frolova
Recruiting

https://ift.tt/2MVRAq7

HPV-E6-Specific TCR-T Cells in the Treatment of HPV-Positive NHSCC or Cervical Cancer

Conditions:   Cervical Cancer;   Head and Neck Squamous Cell Carcinoma
Intervention:   Drug: HPV E6-specific TCR-T cells
Sponsors:   Xinqiao Hospital of Chongqing;   TCRCure Biotech Co., Ltd
Not yet recruiting

https://ift.tt/2KGssr6

To Investigate the Molecular Mechanism of Traditional Chinese Medicine Constitution Using Next-generation Sequencing in Nasopharyngeal Carcinoma

Condition:   Nasopharyngeal Carcinoma
Interventions:   Drug: Danggui Buxue Tang;   Drug: Placebo
Sponsor:   China Medical University Hospital
Recruiting

https://ift.tt/2KVgoS9

Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy

Conditions:   Salivary Gland Dysfunction;   Xerostomia;   Head and Neck Cancer
Interventions:   Drug: Everolimus;   Other: Laboratory Biomarker Analysis;   Other: Survey Administration
Sponsors:   University of Arizona;   National Cancer Institute (NCI)
Recruiting

https://ift.tt/2MVsmbN

Contrast-Enhanced Ultrasound Identification of Sentinel Nodes in Esophageal Cancer

Condition:   Esophagus
Interventions:   Procedure: Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA);   Procedure: Contrast-Enhanced Ultrasound;   Procedure: Fine-Needle Aspiration;   Drug: Sonazoid (Perflubutane)
Sponsors:   Sidney Kimmel Cancer Center at Thomas Jefferson University;   National Cancer Institute (NCI)
Not yet recruiting

https://ift.tt/2KEY6ow

Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer

Conditions:   Esophageal Neoplasms;   Squamous Cell Carcinoma;   Concurrent Chemoradiotherapy
Interventions:   Drug: Paclitaxel;   Drug: Cisplatin;   Drug: Fluorouracil;   Radiation: chemoradiotherapy;   Procedure: Ivor Lewis esophagogastrectomy
Sponsor:   Mona Frolova
Recruiting

https://ift.tt/2MVRAq7

HPV-E6-Specific TCR-T Cells in the Treatment of HPV-Positive NHSCC or Cervical Cancer

Conditions:   Cervical Cancer;   Head and Neck Squamous Cell Carcinoma
Intervention:   Drug: HPV E6-specific TCR-T cells
Sponsors:   Xinqiao Hospital of Chongqing;   TCRCure Biotech Co., Ltd
Not yet recruiting

https://ift.tt/2KGssr6

Antibiotics alter the window of competence for natural transformation in streptococci

Molecular Oral Microbiology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2u0lfHN

Neuroendocrine correlates of the critical day length response in the Soay sheep

Journal of Neuroendocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2uc5Raw

The Effect of Lithium on the Progression Free and Overall Survival in Patients with Metastatic Differentiated Thyroid Cancer Undergoing Radioactive Iodine Therapy

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MQkN5U

Abnormal irisin level in serum and endometrium is associated with metabolic dysfunction in polycystic ovary syndrome patients

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KCHr5i

Extensive Clinical Experience: Hypothalamic‐Pituitary‐Adrenal Axis Recovery after Adrenalectomy for Corticotropin‐Independent Cortisol Excess

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MSIpXG

Anti‐inflammatory effects of the GAG‐binding CXCL9(74‐103) peptide in dinitrofluorobenzene‐induced contact hypersensitivity in mice

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2m1iykJ

Identification of Peptides with Tolerogenic Potential in a Hydrolyzed Whey‐Based Infant Formula

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ubpgZn

High ambient levels of grass, weed and other pollens are associated with asthma admissions in children and adolescents: A large 5‐year case‐crossover study

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2lZ7ynW

Towards complete identification of allergens in Jack Jumper (Myrmecia pilosula) ant venom and their clinical relevance: An immunoproteomic approach

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2zcqY2s

Prevalence of allergy to human seminal fluid among women with allergy to male dog and sensitization to Can f 5

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2lWjUNR

Threshold‐Stimulated Kallikrein Activity Distinguishes Bradykinin‐ From Histamine‐Mediated Angioedema

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2uagH0D

Cover Image

Clinical &Experimental Allergy, Volume 48, Issue 7, Page i-i, July 2018.


https://ift.tt/2lYWV4C

Best of the Other Journals

Clinical &Experimental Allergy, Volume 48, Issue 7, Page 906-906, July 2018.


https://ift.tt/2zhuVCS

Forthcoming Meetings

Clinical &Experimental Allergy, Volume 48, Issue 7, Page 905-905, July 2018.


https://ift.tt/2lYKhCV

Airway granulocytes in severe preschool wheeze: Predictive of school‐age asthma attacks or disease protection

Clinical &Experimental Allergy, Volume 48, Issue 7, Page 760-761, July 2018.


https://ift.tt/2zi4pJC

Issue Information

Clinical &Experimental Allergy, Volume 48, Issue 7, Page 755-757, July 2018.


https://ift.tt/2lZI7CY

A new approach to oral allergen immunotherapy for food allergy?

Clinical &Experimental Allergy, Volume 48, Issue 7, Page 758-759, July 2018.


https://ift.tt/2zhuMiO

Endoscopic smartphone adaptors in Otolaryngology: How do they compare?

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2IYzH7V

Contrast‐enhanced 18F‐FDG‐PET/CT for Differentiating Tumor and Radionecrosis in Head and Neck Cancer: Our experience in 37 Patients

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KF8BIR

Laryngeal Dysplasia and narrow band imaging: secondary analysis of published data supports the role in patient follow up

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KPHu9P

Unilateral versus bilateral sphenopalatine artery ligation in adult unilateral epistaxis: a comparative retrospective study of 83 cases

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KPQM8T

Revision stapes surgery: A review of 102 cases

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2IYeET1

Endoscopic endonasal surgery to correct congenital obstruction of the lacrimal pathway

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KAMaEC

Minimum clinically important difference for the 22‐item Sinonasal Outcome Test in medically managed patients with chronic rhinosinusitis

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2IYeA5J

Low recurrence rate of head and neck basal cell carcinoma treated with Mohs micrographic surgery: A retrospective study of 1021 cases

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KNXPPD

Patterns of hospital admission in 54, 501 patients with epistaxis over a 20‐year period in Scotland, UK

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KSC11X

Diagnosis of anti‐laminin γ‐1 pemphigoid by immunoblot analysis

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KPQUFp

Physicochemical characterization of inorganic deposits associated with granulomas in cutaneous sarcoidosis

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KSxyfO

A unique presentation of ‘petrified ears’ with pain due to fracture

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KBiQxA

Identifying key components for a psychological intervention for people with vitiligo ‐ a quantitative and qualitative study in the United Kingdom using web‐based questionnaires of people with vitiligo and healthcare professionals

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KPHDdn

A randomized, double‐blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil versus 3% minoxidil solution in the treatment of male androgenetic alopecia

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KCCtFp

Rosacea‐like demodicosis and papulopustular rosacea may be two phenotypes of the same disease, and pityriasis folliculorum may be their precursor. Response to the comment of Tatu

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2IZjLm1

Reliability of the hidradenitis suppurativa clinical response (HiSCR) in the assessment of patients with hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KV0SFT

Dermatology: More than an outpatient specialty

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KV2coW

Real‐life efficacy and safety of secukinumab: Results from a tertiary hospital in Greece

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KO23Xr

Titanium dioxide nanoparticles and frontal fibrosing alopecia: cause or consequence ?

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KU0P9R

Rosacea‐like demodicosis (but not primary demodicosis) and papulo pustular rosacea may be two phenotypes of the same disease‐a microbioma,therapeutic and diagnostic tools perspective

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KzLpeI

Anti‐TNFα therapy modulates mTORC1signalling in hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2J3aaua

Tattooing and psoriasis: dermatologists’ knowledge, attitudes and practices. An international study

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KzX3pX

Severe hypocalcemia‐related pustular psoriasis in an 83‐year‐old woman with Fahr's syndrome: a case report

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2IWzQsw

Psoriasis, metabolic syndrome and cardiovascular risk factors. A population‐based study

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KKnrNp

Photoonycholysis: new findings

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KTF8a2

Dermoscopy in disseminated sporotrichosis

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KLCk1X

Paradoxical Eczematous Reaction to Ixekizumab

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KPHx5v

Prevalence, Predictors and Comorbidity of Dry Skin in the General Population

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KDZnMP

The role of dermoscopy in the diagnosis of deep mycoses and systemic mycoses with cutaneous involvement Comment on “Dermoscopy in disseminated sporotrichosis”

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2IZN6MP

Response to ‘Considering the chemopreventive potential of nicotinamide in Gilmore's Bayesian analysis’

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2u0lgeJ

Pigmented purpura masquerading as acral melanoma

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2ubwBrJ

The effectiveness of combination therapy with 308‐nm excimer laser in vitiligo in Han Chinese People

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2NuFi9t

Vulvo‐vaginal lichen planus: A focussed review for the clinician

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2zdr5L9

Biting down on the truth: A case of a delayed hypersensitivity reaction to lidocaine

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2NwoTkL

Reflectance Confocal Microscopy Features of Melanomas on the Body and Non‐Glabrous Chronically Sun‐Damaged Skin

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NwoPBG

Eruptive poromatosis in a patient with breast cancer

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2IYm2h4

Pediatric CD8+/CD56+ mycosis fungoides with cytotoxic marker expression: a variant with indolent course

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2tZXAHz

p63 and smooth muscle actin expression in low grade spiradenocarcinomas in a case of CYLD cutaneous syndrome

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KRdzhn

Hyperplastic sensory corpuscles in nevus sebaceous of labia minora pudendi. A case report

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2tZVyqN

Prevalence and clinicopathological characteristics of lipomatous neurofibromas in Neurofibromatosis 1: an investigation of 229 cutaneous neurofibromas and a systematic review of the literature

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KQ8NAL

Giant Aneurysmal Benign Fibrous Histiocytoma (Dermatofibroma)

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2u0GRUt

A survey of Australian prosthodontists: the use of posts in endodontically treated teeth

Australian Dental Journal, EarlyView.


https://ift.tt/2uaOFlR

Dento‐maxillofacial Radiology in Australia and Dentist satisfaction with radiology reports

Australian Dental Journal, Volume 0, Issue ja, -Not available-.


https://ift.tt/2lWkoU7

Pregnancy, parity and periodontal disease

Australian Dental Journal, EarlyView.


https://ift.tt/2uaOzuv

Traumatic Optic Neuropathy and Monocular Blindness following Transnasal Penetrating Optic Canal Injury by a Wooden Foreign Body

Purpose: To report a case of right eye blindness due to a penetrating injury in the contralateral nostril. Methods: This is a case report of a 67-year-old patient who presented to the emergency room complaining of transient blurred vision in his right eye after falling on a small branch with no apparent injury besides minor lacerations. The following day, the patient experienced blindness in the right eye. Physical examination revealed small lacerations on his left forehead and optic neuropathy on the right side with no other obvious discerning physical or imaging abnormalities. Results: After elevated suspicion and reassessment of the neuroimaging findings, a radiolucent track was observed in the nasal cavity, continuing up from the left nostril to the right optic nerve. Transnasal endoscopic surgery was performed and a long wooden branch was removed from the nasal cavity. Conclusion: A nasally penetrating wooden foreign body can cause traumatic optic neuropathy and vision loss on the unaffected side and can be very difficult to locate and image without any clear external evidence as to its presence. This case highlights the importance of maintaining a high level of suspicion in these types of cases.
Case Rep Ophthalmol 2018;9:341–347

https://ift.tt/2KDVZBB

Nuclear nonmetastatic protein 23‐H1 expression and epithelial‐mesenchymal transition in laryngeal carcinoma: A pilot investigation

Head &Neck, EarlyView.


https://ift.tt/2KPMMFp

AHNS Series: Do you know your guidelines? Principles for treatment of cancer of the paranasal sinuses: A review of the National Comprehensive Cancer Network guidelines

Head &Neck, EarlyView.


https://ift.tt/2MP61wj

Visualization of nerve fibers around the carotid bifurcation with use of a 9.4 Tesla microscopic magnetic resonance diffusion tensor imaging with tractography

Head &Neck, EarlyView.


https://ift.tt/2KPMLkP

Compartmentalized endoscopic resection of the olfactory cleft for nasal intestinal adenocarcinomas

Head &Neck, EarlyView.


https://ift.tt/2MSCLEY

Survival benefits of adjuvant radiation in the management of early tongue cancer with depth of invasion as the indication

Head &Neck, EarlyView.


https://ift.tt/2KLz46J

Immune sensitization during one year in the Antarctic high altitude Concordia Environment

Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KNVhkt

Human milk oligosaccharide profiles and food sensitization among infants in the CHILD Study

Allergy, EarlyView.


https://ift.tt/2KCx7KA

Three patients with advanced cutaneous angiosarcoma treated with eribulin: investigation of serum soluble CD163 and chemokine (C‐X‐C motif) ligand 10 as possible biomarkers predicting the biological behaviour of angiosarcoma

British Journal of Dermatology, EarlyView.


https://ift.tt/2lWj83h

MUC1 deficiency mediates corticosteroid insensitivity in asthma

Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MVWp34

Prospective study in bullous pemphigoid: association of high serum anti‐BP180 IgG levels with increased mortality and reduced Karnofsky score

British Journal of Dermatology, EarlyView.


https://ift.tt/2u93RQj

A smartphone application supporting patients with psoriasis improves adherence to topical treatment: a randomized controlled trial

British Journal of Dermatology, EarlyView.


https://ift.tt/2lYFtNT

Omalizumab normalizes the gene expression signature of lesional skin in patients with chronic spontaneous urticaria: a randomized, double‐blind, placebo‐controlled study

Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MS0Onn

Does Lindioil (indirubin) treatment affect the composition of Malassezia species on psoriatic skin?

British Journal of Dermatology, EarlyView.


https://ift.tt/2zcp9Ck

Are high‐ and low‐molecular‐weight sensitizing agents associated with different clinical phenotypes of occupational asthma?

Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MTPIyo

A re‐audit of cervical screening uptake in a dermatology cohort on immunosuppressive medications

British Journal of Dermatology, EarlyView.


https://ift.tt/2lYYKif

A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process

British Journal of Dermatology, EarlyView.


https://ift.tt/2zcp4P2

Reduction in pain following treatment with ranolazine in primary erythromelalgia: a case report

British Journal of Dermatology, EarlyView.


https://ift.tt/2lVe53b

Lipidomics reveals skin surface lipid abnormity in acne in young men

British Journal of Dermatology, EarlyView.


https://ift.tt/2ubnMOL

SunSmart schools: a New Zealand skin cancer primary prevention intervention blueprint for primary school settings

British Journal of Dermatology, EarlyView.


https://ift.tt/2lYExsR

Peripheral eosinophilia in bullous pemphigoid: prevalence and influence on the clinical manifestation

British Journal of Dermatology, EarlyView.


https://ift.tt/2u6Z16h

Safety of tildrakizumab for moderate‐to‐severe plaque psoriasis: pooled analysis of three randomized controlled trials

British Journal of Dermatology, EarlyView.


https://ift.tt/2lZCGny

Skin microbiome changes in patients with interdigital tinea pedis

British Journal of Dermatology, EarlyView.


https://ift.tt/2zgFEgJ

Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor‐γ agonist trifarotene

British Journal of Dermatology, EarlyView.


https://ift.tt/2lVp9NA

A traditional Chinese remedy points to a natural skin habitat: indirubin (indigo naturalis) for psoriasis and the Malassezia metabolome

British Journal of Dermatology, EarlyView.


https://ift.tt/2u72Fx5

‘Post‐finasteride syndrome’: what to tell our female patients?

British Journal of Dermatology, EarlyView.


https://ift.tt/2lX6AZF

Cardiovascular disease and atopic dermatitis: epidemiological strengths and limitations

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ubnlnB

Atopic dermatitis: the skin barrier and beyond

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2lZ2S1m

British Teledermatology Society

British Journal of Dermatology, Volume 179, Issue S1, Page 183-186, July 2018.


https://ift.tt/2ubndED

Author Index

British Journal of Dermatology, Volume 179, Issue S1, Page 212-217, July 2018.


https://ift.tt/2lWdzlx

Historical Abstracts

British Journal of Dermatology, Volume 179, Issue S1, Page 187-197, July 2018.


https://ift.tt/2zbiOqS

Combination of 5‐aminolaevulinic acid and iron prevents skin fibrosis in murine sclerodermatous grafts‐versus‐host disease

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2zpU7r5

X‐linked ichthyosis: Clinical and molecular findings in 35 Italian patients

Experimental Dermatology, EarlyView.


https://ift.tt/2NrYpRo

FAM83G/Fam83g genetic variants affect canine and murine hair formation

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2u6Zbup

A proposed mechanism for central centrifugal cicatricial alopecia

Experimental Dermatology, EarlyView.


https://ift.tt/2NrYepc

Peptidylarginine deiminases and deiminated proteins at the epidermal barrier

Experimental Dermatology, EarlyView.


https://ift.tt/2zfWdcS

Red grape (Vitis vinifera L.) flavonoids down‐regulate collagen type III expression after UV‐A in primary human dermal blood endothelial cells

Experimental Dermatology, EarlyView.


https://ift.tt/2tZ7ppj

Inherited epidermolysis bullosa: New diagnostics and new clinical phenotypes

Experimental Dermatology, EarlyView.


https://ift.tt/2zfW35g

Heparinoid suppresses Der p‐induced IL‐1β production by inhibiting ERK and p38 MAPK pathways in keratinocytes

Experimental Dermatology, EarlyView.


https://ift.tt/2tYOQkS

New insights into the roles of myofibroblasts and innervation during skin healing and innovative therapies to improve scar innervation

Experimental Dermatology, EarlyView.


https://ift.tt/2u6DI4M

A bald statement — Current approaches to manipulate miniaturisation focus only on promoting hair growth

Experimental Dermatology, EarlyView.


https://ift.tt/2tUV45p

UVA, metabolism and melanoma: UVA makes melanoma hungry for metastasis

Experimental Dermatology, EarlyView.


https://ift.tt/2zggHSH

Texture analysis of second‐harmonic‐generation images for quantitative analysis of reticular dermal collagen fibre in vivo in human facial cheek skin

Experimental Dermatology, EarlyView.


https://ift.tt/2Nvuw2U

Construction of low contracted 3D skin equivalents by genipin crosslinking

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2u8XFbe

Serum VEGFR‐3 as a potential biomarker in psoriasis

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NrYwfM

In vitro models of dermatophyte infection to investigate epidermal barrier alterations

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2zf5EcF

Physical properties of the photodamaged human skin dermis: rougher collagen surface and stiffer/harder mechanical properties

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NxCLLw

Recent evolution of the human skin barrier

Experimental Dermatology, EarlyView.


https://ift.tt/2zeIV02

Life before and beyond blistering: The role of collagen XVII in epidermal physiology

Experimental Dermatology, EarlyView.


https://ift.tt/2NuaK7S

Tiled array‐based sequencing identifies enrichment of loss‐of‐function variants in the highly homologous filaggrin gene in African‐American children with severe atopic dermatitis

Experimental Dermatology, EarlyView.


https://ift.tt/2zbjGf8

ATP6V0A2‐related cutis laxa in ten novel patients: focus on clinical variability and expansion of the phenotype

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Ns8A8B

Clinical, dermoscopic and histopathological features of a rare cutaneous neural tumour

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KBGjii

Clinical, histological and high‐frequency ultrasonographic evaluation (50 MHz) of morphoea treated with ultraviolet A1 phototherapy

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KPVsbI

Identification and interaction analysis of key genes and microRNAs in atopic dermatitis by bioinformatics analysis

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KBc7Um

Atypical variant of trigeminal trophic syndrome successfully treated with pregabalin: a case report series

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KUUUS6

Squamous cell carcinomas in linear epidermal naevi

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KythBY

The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KUV0Js

Diagnostic features of acquired dermal melanocytosis of the face and extremities

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KCGpWZ

Identification of a novel splice site mutation in the LIPH gene in a Japanese family with autosomal recessive woolly hair

The Journal of Dermatology, EarlyView.


https://ift.tt/2u91E7t

Usefulness of dual‐energy computed tomography for the evaluation of psoriatic arthritis accompanied by knee osteoarthritis

The Journal of Dermatology, EarlyView.


https://ift.tt/2tYc9eN

Microbiome analysis of forehead skin in patients with atopic dermatitis and healthy subjects: Implication of Staphylococcus and Corynebacterium

The Journal of Dermatology, Volume 45, Issue 7, Page 876-877, July 2018.


https://ift.tt/2uaKTsH

Issue Information

The Journal of Dermatology, Volume 45, Issue 7, Page 878-878, July 2018.


https://ift.tt/2Nu65mc

Carboplatin and epirubicin combination therapy for advanced malignant epithelial skin tumors: Retrospective study of six patients

The Journal of Dermatology, Volume 45, Issue 7, Page 874-875, July 2018.


https://ift.tt/2zhu8C2

Issue Information

The Journal of Dermatology, Volume 45, Issue 7, Page i, 753-754, July 2018.


https://ift.tt/2NwT0bR

Long‐term survival of a patient with neurofibromatosis type 1 diagnosed with multiple malignant peripheral nerve sheath tumors

The Journal of Dermatology, EarlyView.


https://ift.tt/2u6DdaU

Chronological clinicopathological characterization of rapidly progressive alopecia areata resistant to multiple i.v. corticosteroid pulse therapies: An implication for improving the efficacy

The Journal of Dermatology, EarlyView.


https://ift.tt/2u24DiQ

Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and a review of Japanese patients

The Journal of Dermatology, EarlyView.


https://ift.tt/2uaDPfA

Incidence of Stevens–Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case–control study

The Journal of Dermatology, EarlyView.


https://ift.tt/2NwhBOe

Germline BRCA1‐associated protein 1 mutation presenting as BAP1 inactivated melanocytic nevi in a child of a father with fatal paraganglioma

Pediatric Dermatology, EarlyView.


https://ift.tt/2zfmAQ4

Clinical algorithm to manage anemia in epidermolysis bullosa

Pediatric Dermatology, EarlyView.


https://ift.tt/2NxBBzE

Guidelines for pediatric anogenital examination: Insights from our vulvar dermatology clinic

Pediatric Dermatology, EarlyView.


https://ift.tt/2uaD85T

Clinical, dermoscopic and histopathological features of a rare cutaneous neural tumour

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KBGjii

Clinical, histological and high‐frequency ultrasonographic evaluation (50 MHz) of morphoea treated with ultraviolet A1 phototherapy

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KPVsbI

Identification and interaction analysis of key genes and microRNAs in atopic dermatitis by bioinformatics analysis

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KBc7Um

Atypical variant of trigeminal trophic syndrome successfully treated with pregabalin: a case report series

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KUUUS6

Squamous cell carcinomas in linear epidermal naevi

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KythBY

The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KUV0Js

Diagnostic features of acquired dermal melanocytosis of the face and extremities

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2KCGpWZ

Assessment of hepato-renal damage and genotoxicity induced by long-term exposure to five permitted food additives in rats

Abstract

The present study assessed the long-term daily administration of benzoic acid (BA), potassium sorbate (PS), chlorophyll (CPL), tartrazine (TAZ), and butylated hydroxyanisole (BHA) on hepato-renal changes and DNA damage in rats. Animals were orally administered with the 10 times of the acceptable daily intake (ADI) from each tested substance daily for 60 consecutive days. Blood, liver, and kidney samples were collected to evaluate hematological, biochemical, histopathological, and genotoxic alterations. The extent of liver and kidney damage was evaluated by comet assay and histopathologically. Significant reduction of leukocyte numbers and lymphocytes % in CPL- and TAZ-treated rats. However, significant increases in platelet count in all treated groups after 60 days were detected. The levels of serum transaminases enzymes (ALT, AST), alkaline phosphatase (ALP), and creatinine were significantly increased in all treatments except with BHA group, but no substantial differences were found in urea after 60 days. Aside from BHA, results of DNA damage revealed significant increases in tailed nuclei, tail moment, DNA% in the tail, and tail length in liver and kidney at different degrees. Moreover, the histopathological figures of liver and kidneys affirmed destructive and degenerative changes. The study indicates that most of the tested food additives may provoke genotoxicity and hepato-nephropathy, which could be serious for human health. Therefore, it is necessary to be informed about the hazardous effects of food additives and more attention should be focused towards using natural substitutes.

https://ift.tt/2KWkK8l

Fractional 532‐nm KTP diode laser and 595‐nm pulsed dye laser in treatment of facial telangiectatic erythema

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2KUqG4C

Fractional 532‐nm KTP diode laser and 595‐nm pulsed dye laser in treatment of facial telangiectatic erythema

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2KUqG4C

Effective permeation of 2.5 and 5% lidocaine hydrochloride in human skin using iontophoresis technique

International Journal of Dermatology, EarlyView.


https://ift.tt/2MTZJvg

Psoriasis in Israel: demographic, epidemiology, and healthcare services utilization

International Journal of Dermatology, EarlyView.


https://ift.tt/2KyHBdT

Acne prevalence in 9 to 14‐year‐old old patients attending pediatric ambulatory clinics in Italy

International Journal of Dermatology, EarlyView.


https://ift.tt/2MQXwAQ

Direct‐acting antiviral drugs are triggers for psoriasis: report of three cases

International Journal of Dermatology, EarlyView.


https://ift.tt/2KOJeDC

Early psoriatic arthritis in psoriatic patients: risk factors and screening for rheumatological evaluation

International Journal of Dermatology, EarlyView.


https://ift.tt/2MSoJD9

Skin bacterial colonizations and superinfections in immunocompetent patients with scabies

International Journal of Dermatology, EarlyView.


https://ift.tt/2KBblqq

Recurrent deep venous thrombosis in a leprosy patient on Sofosbuvir regimen for HCV: a lepra reaction?

International Journal of Dermatology, EarlyView.


https://ift.tt/2MRXCbn

Tracing the origins of active amide group‐positive drug‐induced pemphigus vulgaris along the Silk Road: a case report of candesartan‐induced pemphigus vulgaris and review of nonthiol drug‐induced pemphigus

International Journal of Dermatology, EarlyView.


https://ift.tt/2KQMGNK

An acute acral papulovesicular eruption

International Journal of Dermatology, EarlyView.


https://ift.tt/2MQAUAy

Novel mutation in MBTPS2 causes keratosis follicularis spinulosa decalvans in a large Chinese family

International Journal of Dermatology, EarlyView.


https://ift.tt/2KB5yB3

Metals in fish of different trophic levels in the area of influence of the AHE Foz do Chapecó reservoir, Brazil

Abstract

In regions where there is intense polluting activity, a greater availability of metals in water impounded by dams increases the availability and contamination of the fauna and flora. Thus, we assessed the accumulation of metals in muscle and gills of fish of different trophic levels in the area of influence of Foz do Chapecó hydroelectric plant on the Uruguai river. We analyzed the metals Pb, Cd, Cu, Cr, Mn, Zn, and Fe in Hypostomus isbrueckeri (cascudo), Pimelodus maculatus (mandi), and Salminus brasiliensis (dourado). We collected specimens from both upstream and downstream of the reservoir in February and March 2014. We also measured the allometric condition factor of the fish to determine their physiological status. Physical and chemical variables of the water were measured to determine the influence of these abiotic variables on the bioavailability of metals and on the condition factor of the fish. Gills had a higher concentration of metals than muscle. Hypostomus isbrueckeri and Pimelodus maculatus possessed high concentrations of metals, indicating greater bioaccumulation in benthic species. Only chromium in muscle varied significantly between upstream and downstream, with higher concentrations in H. isbrueckeri and P. maculatus upstream. Chromium contamination, however, did not change the condition factor, which did not vary between upstream and downstream for any of the studied species. We found no influence of abiotic variables of the water on the bioavailability of the metals in the environment. Although the data do not indicate trophic magnification, the different species react differently to environmental changes and their trophic plasticity makes it difficult to assign them to specific guilds.

https://ift.tt/2KO88Tz

Cortical Neuron Migration and Dendrite Morphology are Regulated by Carboxypeptidase E

Abstract

Higher brain function relies on proper development of the cerebral cortex, including correct positioning of neurons and dendrite morphology. Disruptions in these processes may result in various neurocognitive disorders. Mutations in the CPE gene, which encodes carboxypeptidase E (CPE), have been linked to depression and intellectual disability. However, it remains unclear whether CPE is involved in early brain development and in turn contributes to the pathophysiology of neurocognitive disorders. Here, we investigate the effects of CPE knockdown on early brain development and explore the functional significance of the interaction between CPE and its binding partner p150^Glued. We demonstrate that CPE is required for cortical neuron migration and dendrite arborization. Furthermore, we show that expression of CPE-C10 redistributes p150^Glued from the centrosome and that disruption of CPE interaction with p150^Glued leads to abnormal neuronal migration and dendrite morphology, suggesting that a complex between CPE and p150^Glued is necessary for proper neurodevelopment.

https://ift.tt/2lYSdUM

Sparse Labeling and Neural Tracing in Brain Circuits by STARS Strategy: Revealing Morphological Development of Type II Spiral Ganglion Neurons

Abstract

Elucidating axonal and dendritic projection patterns of individual neurons is a key for understanding the cytoarchitecture of neural circuits in the brain. This requires genetic approaches to achieve Golgi-like sparse labeling of desired types of neurons. Here, we explored a novel strategy of stochastic gene activation with regulated sparseness (STARS), in which the stochastic choice between 2 competing Cre-lox recombination events is controlled by varying the lox efficiency and cassette length. In a created STARS transgenic mouse crossed with various Cre driver lines, sparse neuronal labeling with a relatively uniform level of sparseness was achieved across different brain regions and cell types in both central and peripheral nervous systems. Tracing of individual type II peripheral auditory fibers revealed for the first time that they undergo experience-dependent developmental refinement, which is impaired by attenuating external sound input. Our results suggest that STARS strategy can be applied for circuit mapping and sparse gene manipulation.

https://ift.tt/2NsUGDr

Neural Basis of Sensorimotor Plasticity in Speech Motor Adaptation

Abstract

When we speak, we get correlated sensory feedback from speech sounds and from the muscles and soft tissues of the vocal tract. Here we dissociate the contributions of auditory and somatosensory feedback to identify brain networks that underlie the somatic contribution to speech motor learning. The technique uses a robotic device that selectively alters somatosensory inputs in combination with resting-state fMRI scans that reveal learning-related changes in functional connectivity. A partial correlation analysis is used to identify connectivity changes that are not explained by the time course of activity in any other learning-related areas. This analysis revealed changes related to behavioral improvements in movement and separately, to changes in auditory perception: Speech motor adaptation itself was associated with connectivity changes that were primarily in non-motor areas of brain, specifically, to a strengthening of connectivity between auditory and somatosensory cortex and between presupplementary motor area and the inferior parietal lobule. In contrast, connectively changes associated with alterations to auditory perception were restricted to speech motor areas, specifically, primary motor cortex and inferior frontal gyrus. Overall, our findings show that during adaptation, somatosensory inputs result in a broad range of changes in connectivity in areas associated with speech motor control and learning.

https://ift.tt/2u6oRr2

Neuronal Mechanisms Recording the Stream of Consciousness–A Reappraisal of Wilder Penfield’s (1891–1976) Concept of Experiential Phenomena Elicited by Electrical Stimulation of the Human Cortex

Abstract

Research on memory has been a major focus in the neurosciences over the past decades. An important advance was achieved by Wilder Penfield at the Montreal Neurological Institute, who reported from the 1930s to the 1950s about experiential phenomena induced by electrical brain stimulation in humans, implying neuronal causation of memory. Since then, neuroscientists have addressed the topic of memory from a range of subdisciplines; however, these reports by Penfield and his group as well as those on patient H. M. by Brenda Milner at the same institution continue to be referenced as groundbreaking. Further experimental work by Nobel laureates Eric Kandel and John O'Keefe, as well as by Edvard and May-Britt Moser related Penfield's patient documentation to experiential phenomena. However, our reassessment of Penfield's original patient documentation questions the stance that he had uncovered the "storehouse of memories." Human memory must be regarded more as context sensitive and as representative of an active reconstructive process, than as a simple recording of events. Hence, strategies aiming at naturalizing all phenomena of mind (including memory) to cellular and molecular mechanisms cannot convincingly refer to Penfield's electrophysiological studies alone as evidence that memories are solely caused by neuronal firing patterns.

https://ift.tt/2tZ0fRQ

G9a/GLP Complex Acts as a Bidirectional Switch to Regulate Metabotropic Glutamate Receptor-Dependent Plasticity in Hippocampal CA1 Pyramidal Neurons

Abstract

Metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) is conventionally considered to be solely dependent on local protein synthesis. Given the impact of epigenetics on memory, the intriguing question is whether epigenetic regulation influences mGluR-LTD as well. G9a/GLP histone lysine methyltransferase complex is crucial for brain development and goal-directed learning as well as for drug-addiction. In this study, we analyzed whether the epigenetic regulation by G9a/GLP complex affects mGluR-LTD in CA1 hippocampal pyramidal neurons of 5–7 weeks old male Wistar rats. In hippocampal slices with intact CA1 dendritic regions, inhibition of G9a/GLP activity abolished mGluR-LTD. The inhibition of this complex upregulated the expression of plasticity proteins like PKMζ, which mediated the prevention of mGluR-LTD expression by regulating the NSF-GluA2-mediated trafficking of AMPA receptors towards the postsynaptic site. G9a/GLP inhibition during the induction of mGluR-LTD also downregulated the protein levels of phosphorylated-GluA2 and Arc. Interestingly, G9a/GLP inhibition could not impede the mGluR-LTD when the cell-body was severed. Our study highlights the role of G9a/GLP complex in intact neuronal network as a bidirectional switch; when turned on, it facilitates the expression of mGluR-LTD, and when turned off, it promotes the expression of long-term potentiation.

https://ift.tt/2u9j2cx

Qualitative evaluation of ferritin in serum samples by Raman spectroscopy and principal component analysis

Abstract

Iron molecule is of great importance in the synthesis of hemoglobin which is essential for oxygen transport. Iron levels are quantified by accurately high sensitivity tests, such as serum ferritin (SF). However, common studies to quantify SF are long and strenuous (~ 5 h), for example enzyme-linked immunosorbent assay (ELISA). In this paper, blood serum samples were analyzed by Raman spectroscopy (RS), and a computational analysis of spectra is proposed to detect differences in SF as an alternative procedure. Serum samples were obtained from 22 patients, 9 who were clinically diagnosed with anemia and 13 controls. Patients with anemia had low levels of SF (< 30 ng/ml), and a control group had levels between 30 and 500 ng/ml. The spectra obtained were conditioned with a baseline correction and smoothing, then evaluated by principal component analysis (PCA), and a predictive model was estimated by lineal discrimination analysis (LDA). The results showed a clear differentiation of the study groups by PCA, also 99.69% sensitivity and 100% specificity by LDA. This study suggest that Raman spectroscopy is a fast (~ 5 min) and a powerful tool capable to qualitative differentiate ferritin concentrations.

https://ift.tt/2zlNupI

Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition

Publication date: Available online 5 July 2018

Source: Trends in Endocrinology & Metabolism

Author(s): Dongxing Zhu, Xiaosa Li, Vicky E. Macrae, Tommaso Simoncini, Xiaodong Fu

The risk of osteoporosis and cardiovascular disease increases significantly in postmenopausal women. Until recently, the underlying mechanisms have been primarily attributed to estrogen decline following menopause. However, follicle-stimulating hormone (FSH) levels rise sharply during menopausal transition and are maintained at elevated levels for many years. FSH receptor has been detected in various extragonadal sites, including osteoclasts and endothelial cells. Recent advances suggest FSH may contribute to postmenopausal osteoporosis and cardiovascular disease. Here, we review the key actions through which FSH contributes to the risk of osteoporosis and cardiovascular disease in women as they transition through menopause. Advancing our understanding of the precise mechanisms through which FSH promotes osteoporosis and cardiovascular disease may provide new opportunities for improving health-span for postmenopausal women.

https://ift.tt/2zfVbNV