Publication date: Available online 10 January 2018
Source:European Journal of Vascular and Endovascular Surgery
Author(s): Vladimir Makaloski, Konstantinos Spanos, Jürg Schmidli, Tilo Kölbel
http://ift.tt/2FseDWD
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- Surveillance After Endovascular Treatment for Blun...
- Endometrial Adenocarcinoma With Pulmonary Recurrence
- Cervical ganglioneuroma: clinical and radiological...
- Rare cause of pulmonary cavitation in a 75-year-ol...
- Intradiploic cephalocele: a rare entity at a rare ...
- Sternocleidomastoid tumour in neonate: fibromatosi...
- Ninety-year-old man with hypereosinophilia, lympha...
- Degradation of organics extracted from dewatered s...
- Response to ‘Serological diagnostics in the detect...
- Ticagrelor inhibits platelet–tumor cell interactio...
- Relationship between α-melanocyte stimulating horm...
- Relationship between α-melanocyte stimulating horm...
- Kompetenzbasierte Ausbildung im „geschützten Umfel...
- Behandlung im Voraus planen – Bedeutung für die In...
- Begünstigt Kaudalanästhesie postoperative Komplika...
- Hyperchlorämie ist mit akutem Nierenversagen nach ...
- Lernen im geschützten Umfeld
- Simulation als Fortbildungsmethode zur Professiona...
- The Same Procedure As Last Year?
- „Das Kind hat einen Fremdkörper verschluckt“ – was...
- Neurologischer Schaden nach Wirbelsäulen-OP
- Entwicklung neuer Antibiotika: Endpunkte klinische...
- Interventionen zur präoperativen Unterstützung ger...
- Therapiebegrenzung: DIVI empfiehlt neuen Dokumenta...
- Zervikale Plexusblockaden
- Warum und wie sollte ich Frailty erfassen? – ein A...
- Vielen Dank!
- Die meisten Todesbescheinigungen weisen Fehler auf
- Kompetenzbasierte Ausbildung im „geschützten Umfel...
- Behandlung im Voraus planen – Bedeutung für die In...
- Begünstigt Kaudalanästhesie postoperative Komplika...
- „Lernen im geschützten Umfeld“: Implementierung in...
- Hyperchlorämie ist mit akutem Nierenversagen nach ...
- Lernen im geschützten Umfeld
- Etomidat-Analogon mit verringerter Nebennierensupp...
- Simulation als Fortbildungsmethode zur Professiona...
- The Same Procedure As Last Year?
- „Das Kind hat einen Fremdkörper verschluckt“ – was...
- Neurologischer Schaden nach Wirbelsäulen-OP
- Atemübungen schützen ältere Patienten vor gefährli...
- Interventionen zur präoperativen Unterstützung ger...
- Therapiebegrenzung: DIVI empfiehlt neuen Dokumenta...
- Zervikale Plexusblockaden
- Warum und wie sollte ich Frailty erfassen? – ein A...
- Die meisten Todesbescheinigungen weisen Fehler auf
- Patienten mit Frailty: Anästhesiologie in der Vera...
- Laser treatment of primary axillary hyperhidrosis:...
- Necrotizing fasciitis. Possible profiles of profes...
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- Kartagener’s syndrome: a case report
- Editorial: Special Issue “Effect-related evaluatio...
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- Removal of cadmium in aqueous solution using wheat...
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- ‘Hidden’ occupational allergens such as additives
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- Association of cord blood ghrelin, leptin and insu...
- EAACI Guidelines on Allergen Immunotherapy – Out W...
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τετάρτη 10 Ιανουαρίου 2018
Surveillance After Endovascular Treatment for Blunt Thoracic Aortic Injury
Endometrial Adenocarcinoma With Pulmonary Recurrence
Description
We present the case of an 83-year-old woman with a history of grade 1 stage IB endometrial cancer (endometrial adenocarcinoma) (figure 1) involving the lower uterine segment. She underwent robotic hysterectomy with right salpingo-oophorectomy followed by brachytherapy. A year and a half later, she presented with difficulty in breathing. A chest X-ray showed 8 mm nodular density in the right lower lobe. The above finding was confirmed with CT. Given the concern for a malignant lesion, positron emission tomography/CT scan was performed, which revealed two metabolically active lung nodules, measuring 1.2 cm in the right middle lobe and other in the right lower lobe measuring 1.2 cm (figure 2). Video-assisted thoracoscopic wedge resection of the right lower lobe lung nodule was performed. The frozen section and histopathology revealed papillary adenocarcinoma (figures 3 and 4); nuclear staining was positive for oestrogen receptors and negative for thyroid...
http://ift.tt/2CQdR4i
Cervical ganglioneuroma: clinical and radiological features of a rare tumour
Description
Ganglioneuromas are rare benign tumours of neurogenic origin that most frequently develop in the cervical sympathetic chain,1 2 with genetic associations demonstrated with Neurofibromatosis type 1 (NF-1). We report the case of a 41-year-old woman with a history of cavum neoplasm at the age of 23. This tumour was classified after assessment of extension as T1N0M0 (tumour, node, metastases). Pathological examination of a biopsy concluded to a keratinising squamous cell carcinoma. The patient was then irradiated (2D Cobalt radiotherapy). The patient presented with gait trouble that appeared a few weeks ago. Clinical examination found a Brown-Séquard syndrome with paresis and loss of proprioception on the left side, and loss of pain and temperature sensation on the right side. Medullar MRI (figures 1 and 2) showed an intradural extramedullary well-circumscribed mass with an hourglass shape from C5 to C6 extending through the...
http://ift.tt/2DhvSJE
Rare cause of pulmonary cavitation in a 75-year-old man
A 75-year-old man of Asian descent presented to the acute medical unit with signs and symptoms suggestive of a community-acquired pneumonia. He had multiple comorbidities and was relatively immunocompromised as a result. Initial investigations supported the diagnosis of community-acquired pneumonia complicated by a cavitating lung lesion, and the patient was treated as per hospital guidelines. He continued to deteriorate despite appropriate therapy and developed a hydropneumothorax, requiring the insertion of a chest drain. A diagnosis of pulmonary mucormycosis (Rhizopus microsporus) was made based on microbiology results from pleural aspirate, and patient was treated with intravenous antifungals. The patient was referred to the thoracic team for consideration of surgical intervention but was not suitable due to his multiple comorbidities. This case highlighted the importance of early consideration of fungal infection in patients with multiple risk factors and the need for aggressive therapy to ensure the best outcome.
http://ift.tt/2CQGgac
Intradiploic cephalocele: a rare entity at a rare site
Description
A 52-year-old woman presented with complaints of non-specific headache. The patient had a history of head injury 1 year ago. Clinical neurological examination was nil significant. The skin over the occipital region is normal. No prior investigations were done immediately after the injury. MRI of the brain at present showed small intradiploic cerebrospinal fluid (CSF)-filled defect with herniation of foliae of the right cerebellar hemisphere (figure 1). The rest of the brain parenchyma revealed no abnormality and no skull fracture was seen. Features were suggestive of intradiploic cephalocele involving cerebellar foliae.
Figure 1
Axial Fluid attenuated inversion recovery (A), T2 (B), coronal T2 (C) and sagittal T1 (D) images at the level of the cerebellum showing small calvarial defect in the occipital bone on the right side with intradiploic herniation of the right cerebellar foliae (black arrows).
A cephalocele is...
http://ift.tt/2DiQSjm
Sternocleidomastoid tumour in neonate: fibromatosis colli
Description
We report a case of a 4-week-old female neonate who was admitted to the hospital for a anterior right lump of the neck, perceived by his mother the day before. The mother also noticed a preferential tilting of the head towards right. He was an otherwise full-term healthy baby, with a history of instrumented delivery. There was no fever, trauma or respiratory symptoms/signs. Family history was irrelevant. On examination, the neck swelling was a small firm, partially mobile, no warm on touch and apparently painless mass, with approximately 1.5–2 cm soft tissue mass, attached to the right sternocleidomastoid muscle. There was no restriction of neck movements. Ultrasonography (USG) revealed a 13 mm fusiform thickening of the right sternocleidomastoid muscle, with maintained structure of muscle fibres (figures 1 and 2). No cervical lymphadenopathy, signs of infiltration or other anomalies were found (figures 1 and...
http://ift.tt/2CThuXb
Ninety-year-old man with hypereosinophilia, lymphadenopathies and pruritus
We report a case of a 90-year-old man with hypereosinophilia, lymphadenopathies and skin lesions, namely lichenification and pruritus. An aetiological investigation was performed, and a bone marrow (BM) biopsy and aspirate showed a hypercellular marrow with hypereosinophilia without dysmorphia or abnormal elements, and the BM and inguinal node's immunophenotyping denied any presence of abnormal lymphoid cell population. The inguinal node biopsy revealed a multinodular proliferation of large cells S100 and CD1a+, and a diagnosis of Langerhans cell histiocytosis was made. The hypereosinophilia and skin lesions were managed with corticotherapy with substantial improvement of cutaneous lesions and lymphadenopathies and normalisation of eosinophil count. Finally, to define if it is a single or multisystem disease, a skin biopsy will be necessary.
http://ift.tt/2DiXy0W
Degradation of organics extracted from dewatered sludge by alkaline pretreatment in microbial electrolysis cell
Abstract
Waste activated sludge in China are mostly subjected to dewatering process before final disposal without stabilization. This study investigated the feasibility of organics degradation and H2 production from non-stabilized dewatered sludge (DS) by microbial electrolysis cells (MECs). Alkaline pretreatment was used to disintegrate sludge matrix and solubilize organic matters in DS. Then, the treatment performance of DS supernatant in a single-chamber MEC at various applied voltages was investigated. The COD (chemical oxygen demand) removal rate increased with increasing voltage, which ranged from 26.35 to 44.92% at 0.5–0.9 V. The average coulombic efficiency was 75.6%, while the cathodic hydrogen recovery was not satisfied (15.56–20.05%) with H2 production rates of 0.027–0.038 m3 H2/(m3 day). The reasons could be ascribed to the complexity of the substrate, H2 loss, and the confinement of configuration in scale-up. The organic matter degradation was influenced by the composition of DS. The carbohydrates could be readily used; meanwhile, the major component of the DS supernatant, i.e. proteins, was difficult to be utilized, which resulted from the low biodegradability of the transphilic fractions during the MEC operation.
http://ift.tt/2mpJlrH
Response to ‘Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis': reply from authors
http://ift.tt/2CZHXX3
Ticagrelor inhibits platelet–tumor cell interactions and metastasis in human and murine breast cancer
Abstract
Activated platelets promote the proliferation and metastatic potential of cancer cells. Platelet activation is largely mediated through ADP engagement of purinergic P2Y12 receptors on platelets. We examined the potential of the reversible P2Y12 inhibitor ticagrelor, an agent used clinically to prevent cardiovascular and cerebrovascular events, to reduce tumor growth and metastasis. In vitro, MCF-7, MDA-MB-468, and MDA-MB-231 human mammary carcinoma cells exhibited decreased interaction with platelets treated with ticagrelor compared to untreated platelets. Prevention of tumor cell–platelet interactions through pretreatment of platelets with ticagrelor did not improve natural killer cell-mediated tumor cell killing of K562 myelogenous leukemia target cells. Additionally, ticagrelor had no effect on proliferation of 4T1 mouse mammary carcinoma cells co-cultured with platelets, or on primary 4T1 tumor growth. In an orthotopic 4T1 breast cancer model, ticagrelor (10 mg/kg), but not clopidogrel (10 mg/kg) or saline, resulted in reduced metastasis and improved survival. Ticagrelor treatment was associated with a marked reduction in tumor cell–platelet aggregates in the lungs at 10, 30 and 60 min post-intravenous inoculation. These findings suggest a role for P2Y12-mediated platelet activation in promoting metastasis, and provide support for the use of ticagrelor in the prevention of breast cancer spread.
http://ift.tt/2CQ01ii
Relationship between α-melanocyte stimulating hormone levels and therapeutic outcome of melanocyte transplantation and phototherapy in non-segmental patients with vitiligo: A prospective study
http://ift.tt/2DhfhWz
Relationship between α-melanocyte stimulating hormone levels and therapeutic outcome of melanocyte transplantation and phototherapy in non-segmental patients with vitiligo: A prospective study
http://ift.tt/2DhfhWz
Kompetenzbasierte Ausbildung im „geschützten Umfeld“: vom Schonraum zum Realraum
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 12-19
DOI: 10.1055/s-0043-105257
„Lernen im geschützten Umfeld" ist ein häufig gebrauchter, aber unklarer Begriff im Rahmen der anästhesiologischen postgradualen Weiterbildung. Dieser Artikel beleuchtet seine Bedeutung in der Anästhesiologie – einschließlich Lehr- und Lernstrategien, wie kompetenzorientierte und simulationsbasierte Ausbildung. Ein Versuch der Klassifikation von Simulatoren und Unterrichtsmethoden sowie deren Probleme bei der Umsetzung runden den Beitrag ab.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
http://ift.tt/2FqW0Tc
Behandlung im Voraus planen – Bedeutung für die Intensiv- und Notfallmedizin
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 62-70
DOI: 10.1055/s-0042-118690
Behandlung im Voraus planen (BVP) – im Englischen Advance Care Planning (ACP) – etabliert sich auch in Deutschland als ein neues Konzept zur Realisierung wirksamer Patientenverfügungen. Das Konzept beinhaltet Prozesse zur Ermittlung, Dokumentation und Umsetzung von Behandlungswünschen für den Fall, dass die Betroffenen nicht (mehr) selbst entscheiden können.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
http://ift.tt/2EwIFHs
Begünstigt Kaudalanästhesie postoperative Komplikationen nach Hypospadie-OP?
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 6-7
DOI: 10.1055/s-0043-123122
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FoN2Wn
Hyperchlorämie ist mit akutem Nierenversagen nach SAB verbunden
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 7-8
DOI: 10.1055/s-0043-123121
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FoN2pl
Lernen im geschützten Umfeld
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 10-11
DOI: 10.1055/s-0043-122170
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FqW2ui
Simulation als Fortbildungsmethode zur Professionalisierung von Teams
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 20-33
DOI: 10.1055/s-0043-105261
Simulation ist eine Methode, virtuelle Lernumgebungen zu erzeugen. Mittels Simulation können Technical Skills, aber auch Soft Skills wie die Funktionsfähigkeit von Teams sehr gut vermittelt werden. Dieser Team-Aspekt wird nachfolgend vor dem Hintergrund spezifischer Trainingsmethoden näher beleuchtet. Der Artikel bezieht sich dabei auf „Zwischenfalltrainings", die in den Zentren der Autoren einen großen Anteil des Kursangebotes einnehmen.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2EwJno6
The Same Procedure As Last Year?
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 9-9
DOI: 10.1055/s-0043-123165
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FoN1lh
„Das Kind hat einen Fremdkörper verschluckt“ – was tun?
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 48-60
DOI: 10.1055/s-0042-120991
Sowohl Ingestions- als auch Aspirationsunfälle sind häufige Ereignisse bei Kindern. Sie können unmittelbar lebensbedrohlich sein oder bei fehlender direkter Bedrohung dennoch erhebliche langfristige Beeinträchtigungen für die Kinder verursachen. Der Beitrag zeigt die diagnostischen und therapeutischen Möglichkeiten und Notwendigkeiten auf, durch die eine bestmögliche Sicherheit und möglichst geringe Folgeschäden zu gewährleisten sind.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2EwIHPA
Neurologischer Schaden nach Wirbelsäulen-OP
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 71-75
DOI: 10.1055/s-0043-122628
Schlichtungsstellen für Arzthaftpflichtfragen bieten Patienten, Ärzten und Versicherern eine Möglichkeit, Arzthaftungsstreitigkeiten außergerichtlich zu klären. In der Rubrik „Fälle der Schlichtungsstelle" stellen wir abgeschlossene Fälle aus der Schlichtungsstelle für Arzthaftpflichtfragen der norddeutschen Ärztekammern vor.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FqVPHw
Entwicklung neuer Antibiotika: Endpunkte klinischer Studien teils ungeeignet
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 5-6
DOI: 10.1055/s-0043-117062
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FqW7OC
Interventionen zur präoperativen Unterstützung geriatrischer Patienten mit Frailty
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 777-783
DOI: 10.1055/s-0043-104684
Der stetig zu beobachtende demografische Wandel geht mit veränderten Anforderungen an die Patientenbetreuung einher. Ältere Patienten weisen häufig einen erhöhten Behandlungsbedarf und eine höhere Komplexität des klinischen Gesamtbildes auf. Dieser Umstand ist – abgesehen von der Routineversorgung – besonders dann zu beachten, wenn eine angedachte Intervention zu schweren und potenziell lebensbedrohlichen Komplikationen führen kann.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
http://ift.tt/2D1zvqv
Therapiebegrenzung: DIVI empfiehlt neuen Dokumentationsbogen
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 752-753
DOI: 10.1055/s-0043-119947
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
http://ift.tt/2CZufUd
Zervikale Plexusblockaden
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 806-813
DOI: 10.1055/s-0043-115204
Eine vollständige Blockade des Plexus cervicalis ist weder erwünscht noch ausreichend für eine chirurgische Anästhesie in der vorderen Halsregion. Supplementierungen durch Opioide oder topische Lokalanästhetika sind daher häufig. Die Blockade beteiligter Hirnnerven und des Truncus sympathicus verbessert möglicherweise die Anästhesiequalität, führt aber auch zu typischen Nebenwirkungen. Dieser Beitrag liefert anatomisches Hintergrundwissen und stellt Indikationen vor – auch außerhalb der Karotischirurgie.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2D0SMs5
Warum und wie sollte ich Frailty erfassen? – ein Ansatz für die Anästhesieambulanz
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 765-776
DOI: 10.1055/s-0043-104682
Frailty (Gebrechlichkeit) ist eine Einschränkung der physiologischen Reserve bei älteren Patienten mit schwerwiegenden individuellen und sozioökonomischen Folgen. Multiple Aspekte der Patientenbehandlung sowie das Outcome werden durch Frailty nachhaltig beeinflusst. Obwohl mehr als 60 Messinstrumente existieren, sind die Erfassung und Berücksichtigung funktioneller Assessments in der klinischen Routine unzureichend umgesetzt. Das interdisziplinäre und interprofessionelle Verständnis, warum und wie Frailty beurteilt werden sollte, ist die Grundlage für die dauerhafte Implementierung. Der Artikel zeigt die Auswirkungen von Frailty und Vorteile einer Früherkennung auf und gibt einen Überblick über die wichtigsten Instrumente, die in der Frailty-Erkennung und -Bewertung verwendet werden können. Die frühe präoperative Detektion bietet ein vielfältiges Optimierungspotenzial für die peri- und intraoperative Versorgung. Verschiedene Frailty-Assessment-Tools körperlicher, kognitiver und psychosozialer Domänen werden vorgestellt und diskutiert. Frailty-Assessments variieren immens in Bezug auf die erforderliche Zeit, die Ausrüstung und das Fachwissen zur Durchführung. Wir empfehlen mindestens einen Test für die einzelnen Dimensionen von Frailty, um ein holistisches Bild der geriatrischen Patienten zu erhalten. Die Bewertung von Frailty sollte übergreifend in die interdisziplinären Strukturen der klinischen Routine implementiert werden, um die Patientensicherheit sowie das kurz- und langfristige Outcome zu verbessern.
[...]
Georg Thieme Verlag KG Stuttgart · New York
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http://ift.tt/2D22nik
Vielen Dank!
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 754-754
DOI: 10.1055/s-0043-121256
Georg Thieme Verlag KG Stuttgart · New York
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http://ift.tt/2D22kTG
Die meisten Todesbescheinigungen weisen Fehler auf
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 752-752
DOI: 10.1055/s-0043-121621
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
http://ift.tt/2CZLFQy
Kompetenzbasierte Ausbildung im „geschützten Umfeld“: vom Schonraum zum Realraum
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 12-19
DOI: 10.1055/s-0043-105257
„Lernen im geschützten Umfeld" ist ein häufig gebrauchter, aber unklarer Begriff im Rahmen der anästhesiologischen postgradualen Weiterbildung. Dieser Artikel beleuchtet seine Bedeutung in der Anästhesiologie – einschließlich Lehr- und Lernstrategien, wie kompetenzorientierte und simulationsbasierte Ausbildung. Ein Versuch der Klassifikation von Simulatoren und Unterrichtsmethoden sowie deren Probleme bei der Umsetzung runden den Beitrag ab.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
http://ift.tt/2FqW0Tc
Behandlung im Voraus planen – Bedeutung für die Intensiv- und Notfallmedizin
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 62-70
DOI: 10.1055/s-0042-118690
Behandlung im Voraus planen (BVP) – im Englischen Advance Care Planning (ACP) – etabliert sich auch in Deutschland als ein neues Konzept zur Realisierung wirksamer Patientenverfügungen. Das Konzept beinhaltet Prozesse zur Ermittlung, Dokumentation und Umsetzung von Behandlungswünschen für den Fall, dass die Betroffenen nicht (mehr) selbst entscheiden können.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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Begünstigt Kaudalanästhesie postoperative Komplikationen nach Hypospadie-OP?
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 6-7
DOI: 10.1055/s-0043-123122
Georg Thieme Verlag KG Stuttgart · New York
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„Lernen im geschützten Umfeld“: Implementierung in die Fort- und Weiterbildung
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 35-46
DOI: 10.1055/s-0043-105259
Aktuelle Aus- und Fortbildungskonzepte in der Akut- oder Notfallmedizin beinhalten Simulations- und Skill-Trainings unter Berücksichtigung von Methoden und Mechanismen der Fehler- und Zwischenfallprävention wie Human Factors, Shared mental Models und Closed-Loop-Communication. Immer noch ungeklärt ist die Frage nach der optimalen Kombination der einzelnen Methoden und Inhalte eines Fortbildungsprogramms in Abhängigkeit von individuellen Abteilungen eines Krankenhauses und dem einzelnen Mitarbeiter bzw. seinem individuellen Ausbildungsstand. Ein von uns angebotenes Konzept ist das „Lernen im geschützten Umfeld": Hier werden Teilnehmer und Patient vor den negativen Auswirkungen einer konventionellen klinisch-praktischen Ausbildungssituation beschützt. Gleichzeitig profitieren die Teilnehmer in unserem Fortbildungsprogramm von standardisierten Kursmodellen. Das Ziel der optimalen Vorbereitung auf die klinische Tätigkeit und einer möglichst praktischen bzw. wirklichkeitsnahen Aus- und Fortbildung wird durch eine ständige Re-Evaluation der Inhalte und Methoden komplettiert. Die Implementierung eines solchen multimodalen Teamtrainings ist für jede Institution individuell anzupassen. Die Methoden zur Implementierung sollten standardisiert angewendet werden. Wir empfehlen eine Curriculumsentwicklung auf Grundlage des „Kern-Zyklus". Auf dieser Basis gelingt die Kombination aus „Lernen im geschützten Umfeld" und Zwischenfalltraining zur optimalen Vorbereitung auf eine akutmedizinische, klinische Tätigkeit mit dem Ziel einer höchstmöglichen Patientensicherheit.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FoMVKr
Hyperchlorämie ist mit akutem Nierenversagen nach SAB verbunden
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 7-8
DOI: 10.1055/s-0043-123121
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FoN2pl
Lernen im geschützten Umfeld
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 10-11
DOI: 10.1055/s-0043-122170
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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Etomidat-Analogon mit verringerter Nebennierensuppression
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 8-8
DOI: 10.1055/s-0043-117029
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FqW45o
Simulation als Fortbildungsmethode zur Professionalisierung von Teams
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 20-33
DOI: 10.1055/s-0043-105261
Simulation ist eine Methode, virtuelle Lernumgebungen zu erzeugen. Mittels Simulation können Technical Skills, aber auch Soft Skills wie die Funktionsfähigkeit von Teams sehr gut vermittelt werden. Dieser Team-Aspekt wird nachfolgend vor dem Hintergrund spezifischer Trainingsmethoden näher beleuchtet. Der Artikel bezieht sich dabei auf „Zwischenfalltrainings", die in den Zentren der Autoren einen großen Anteil des Kursangebotes einnehmen.
[...]
Georg Thieme Verlag KG Stuttgart · New York
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The Same Procedure As Last Year?
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 9-9
DOI: 10.1055/s-0043-123165
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FoN1lh
„Das Kind hat einen Fremdkörper verschluckt“ – was tun?
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 48-60
DOI: 10.1055/s-0042-120991
Sowohl Ingestions- als auch Aspirationsunfälle sind häufige Ereignisse bei Kindern. Sie können unmittelbar lebensbedrohlich sein oder bei fehlender direkter Bedrohung dennoch erhebliche langfristige Beeinträchtigungen für die Kinder verursachen. Der Beitrag zeigt die diagnostischen und therapeutischen Möglichkeiten und Notwendigkeiten auf, durch die eine bestmögliche Sicherheit und möglichst geringe Folgeschäden zu gewährleisten sind.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2EwIHPA
Neurologischer Schaden nach Wirbelsäulen-OP
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 71-75
DOI: 10.1055/s-0043-122628
Schlichtungsstellen für Arzthaftpflichtfragen bieten Patienten, Ärzten und Versicherern eine Möglichkeit, Arzthaftungsstreitigkeiten außergerichtlich zu klären. In der Rubrik „Fälle der Schlichtungsstelle" stellen wir abgeschlossene Fälle aus der Schlichtungsstelle für Arzthaftpflichtfragen der norddeutschen Ärztekammern vor.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2FqVPHw
Atemübungen schützen ältere Patienten vor gefährlichen Lungenentzündungen
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 753-753
DOI: 10.1055/s-0043-121213
Georg Thieme Verlag KG Stuttgart · New York
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http://ift.tt/2D2sTbq
Interventionen zur präoperativen Unterstützung geriatrischer Patienten mit Frailty
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 777-783
DOI: 10.1055/s-0043-104684
Der stetig zu beobachtende demografische Wandel geht mit veränderten Anforderungen an die Patientenbetreuung einher. Ältere Patienten weisen häufig einen erhöhten Behandlungsbedarf und eine höhere Komplexität des klinischen Gesamtbildes auf. Dieser Umstand ist – abgesehen von der Routineversorgung – besonders dann zu beachten, wenn eine angedachte Intervention zu schweren und potenziell lebensbedrohlichen Komplikationen führen kann.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2D1zvqv
Therapiebegrenzung: DIVI empfiehlt neuen Dokumentationsbogen
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 752-753
DOI: 10.1055/s-0043-119947
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2CZufUd
Zervikale Plexusblockaden
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 806-813
DOI: 10.1055/s-0043-115204
Eine vollständige Blockade des Plexus cervicalis ist weder erwünscht noch ausreichend für eine chirurgische Anästhesie in der vorderen Halsregion. Supplementierungen durch Opioide oder topische Lokalanästhetika sind daher häufig. Die Blockade beteiligter Hirnnerven und des Truncus sympathicus verbessert möglicherweise die Anästhesiequalität, führt aber auch zu typischen Nebenwirkungen. Dieser Beitrag liefert anatomisches Hintergrundwissen und stellt Indikationen vor – auch außerhalb der Karotischirurgie.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2D0SMs5
Warum und wie sollte ich Frailty erfassen? – ein Ansatz für die Anästhesieambulanz
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 765-776
DOI: 10.1055/s-0043-104682
Frailty (Gebrechlichkeit) ist eine Einschränkung der physiologischen Reserve bei älteren Patienten mit schwerwiegenden individuellen und sozioökonomischen Folgen. Multiple Aspekte der Patientenbehandlung sowie das Outcome werden durch Frailty nachhaltig beeinflusst. Obwohl mehr als 60 Messinstrumente existieren, sind die Erfassung und Berücksichtigung funktioneller Assessments in der klinischen Routine unzureichend umgesetzt. Das interdisziplinäre und interprofessionelle Verständnis, warum und wie Frailty beurteilt werden sollte, ist die Grundlage für die dauerhafte Implementierung. Der Artikel zeigt die Auswirkungen von Frailty und Vorteile einer Früherkennung auf und gibt einen Überblick über die wichtigsten Instrumente, die in der Frailty-Erkennung und -Bewertung verwendet werden können. Die frühe präoperative Detektion bietet ein vielfältiges Optimierungspotenzial für die peri- und intraoperative Versorgung. Verschiedene Frailty-Assessment-Tools körperlicher, kognitiver und psychosozialer Domänen werden vorgestellt und diskutiert. Frailty-Assessments variieren immens in Bezug auf die erforderliche Zeit, die Ausrüstung und das Fachwissen zur Durchführung. Wir empfehlen mindestens einen Test für die einzelnen Dimensionen von Frailty, um ein holistisches Bild der geriatrischen Patienten zu erhalten. Die Bewertung von Frailty sollte übergreifend in die interdisziplinären Strukturen der klinischen Routine implementiert werden, um die Patientensicherheit sowie das kurz- und langfristige Outcome zu verbessern.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2D22nik
Die meisten Todesbescheinigungen weisen Fehler auf
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 752-752
DOI: 10.1055/s-0043-121621
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2CZLFQy
Patienten mit Frailty: Anästhesiologie in der Verantwortung
Anästhesiol Intensivmed Notfallmed Schmerzther 2017; 52: 756-757
DOI: 10.1055/s-0043-117836
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
http://ift.tt/2CZUV77
Laser treatment of primary axillary hyperhidrosis: a review of the literature
Abstract
Hyperhidrosis o`ccurs when the body produces sweat beyond what is essential to maintain thermal homeostasis. The condition tends to occur in areas marked by high-eccrine density such as the axillae, palms, and soles and less commonly in the craniofacial area. The current standard of care is topical aluminum chloride hexahydrate antiperspirant (10–20%), but other treatments such as anticholinergics, clonidine, propranolol, antiadrenergics, injections with attenuated botulinum toxin, microwave technology, and surgery have been therapeutically implicated as well. Yet, many of these treatments have limited efficacy, systemic side effects, and may be linked with significant surgical morbidity, creating need for the development of new and effective therapies for controlling excessive sweating. In this literature review, we examined the use of lasers, particularly the Neodynium:Yttrium-Aluminum-Garnet (Nd:YAG) and diode lasers, in treating hyperhidrosis. Due to its demonstrated effectiveness and limited side effect profile, our review suggests that Nd:YAG laser may be a promising treatment modality for hyperhidrosis. Nevertheless, additional large, randomized controlled trials are necessary to confirm the safety and efficacy of this treatment option.
http://ift.tt/2qSQhSL
Necrotizing fasciitis. Possible profiles of professional liability with reference to two cases.
Related Articles |
Necrotizing fasciitis. Possible profiles of professional liability with reference to two cases.
Ann Ital Chir. 2017 Dec 18;6:
Authors: Marella GL, De Dominicis E, Paliani GB, Santeusanio G, Marsella LT, Potenza S
Abstract
Necrotizing fasciitis is one of the most dangerous complication of an abscess and it is still a disease with a high mortality. In this work, we decided to consider two cases: the first one concerns a male subject, aged 66, deceased because of a fatal necrotizing fasciitis associated to a cervical descending mediastinitis, which evolved from a primary peritonsillar abscess; the second is about a 50-year-old woman with a perineal abscess, then evolved into necrotizing fasciitis associated to a fatal septis shock. After a systematic consideration of necrotizing fasciitis as pathology and an analysis of the possible related risks to a diagnostic or therapeutic delay, we analyzed the particular history of both cases to underline the possible critical issues in professional behavior of the medical staff intervened.
KEY WORDS: Abscess, Medical malpractice, Mortality, Necrotizing fasciitis, Professional liability.
PMID: 29311423 [PubMed - as supplied by publisher]
http://ift.tt/2FrvBEz
Narrow band imaging versus laryngovideostroboscopy in precancerous and malignant vocal fold lesions
Abstract
Background
This is a comparative analysis of the diagnostic accuracy of narrow band imaging (NBI) and laryngovideostroboscopy (LVS) in the assessment of premalignant and malignant vocal fold lesions.
Methods
A prospective analysis was performed on 105 consecutive patients with vocal fold lesions. The NBI and LVS were obtained before the microsurgery.
Results
The NBI and LVS showed no significant differences in identifying premalignant and malignant pathologies. However, in analysis restricted to identification of only malignant lesions, the specificity (88.9% vs 20.6%), accuracy (90.5% vs 51.4%), and positive predictive value (PPV; 84.8% vs 45.1%) were significantly higher for NBI (P value < .001; .015; and .045, respectively). A comparison of LVS scored results relative to each NBI type revealed statistically significant differences (P < .001). A moderate positive correlation between NBI and LVS was demonstrated (P = .54).
Conclusion
The NBI and LVS are useful, complementary tools in evaluating early potential vocal fold malignancies. The NBI was superior to LVS on several statistical analyses.
http://ift.tt/2D36uK7
Unilaterale Halsschwellung – eine überraschende Differentialdiagnose
Laryngo-Rhino-Otol
DOI: 10.1055/s-0043-123651
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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http://ift.tt/2COuhdw
Kartagener’s syndrome: a case report
Kartagener's syndrome is a subset of primary ciliary dyskinesia, an autosomal recessive inherited disorder characterized by the clinical triad of chronic sinusitis, bronchiectasis, and situs inversus. Abnormal...
http://ift.tt/2mqwSE4
Editorial: Special Issue “Effect-related evaluation of anthropogenic trace substances—concepts for genotoxicity, neurotoxicity and endocrine effects”
http://ift.tt/2mg1XcM
Thirty-day readmissions following parathyroidectomy: Evidence from the National Readmissions Database, 2013–2014
Parathyroidectomy is one of the most common procedures performed in the United States, and are increasingly being performed safely in the outpatient setting. However, complications from surgery can be life-threatening, and thus an understanding of who may be at risk is essential. We analyzed and compared the risk factors for patients readmitted within 30 days following inpatient parathyroidectomy for primary or secondary hyperparathyroidism.
http://ift.tt/2EvvTci
Removal of cadmium in aqueous solution using wheat straw biochar: effect of minerals and mechanism
Abstract
The biochars were produced from wheat straw (WSBC) at different pyrolytic temperatures. Biochars were characterized by multiple instrumental techniques and were applied to remove Cd from aqueous solution. The removal mechanism was explored, and the quantitative information regarding the relative contribution of related mechanisms to Cd sorption on biochars was provided. The results showed that pseudo-second-order kinetic model, TC (two-compartment) model, and Freundlich isotherm could well fit the process of Cd sorption on biochars. The sorption could be divided into fast and slow adsorption stages. The order of the Cd removal capacity by biochar was WSBC700 > WSBC500 > WSBC300. Adsorption amount of Cd by biochar reduced when the biochar was rinsed with 1.0 M HCl, which indicated that acid-soluble minerals in biochar played an important role during the Cd removal process, especially for the biochar obtained at high pyrolytic temperature. Various equipments were used to investigate the interaction mechanism between biochar and Cd. Mineral precipitation, surface complexation, and cation-π interaction were the main mechanisms of Cd sorption on the biochars. The contribution of cation-π mechanism was in the range of 25.42–48.58%, 2.18–19.30% for surface complexation and 32.12–72.41% for mineral precipitation, respectively. The pyrolytic temperature significantly influenced the removal capacity and mechanism of Cd on biochars. The cation-π mechanism was predominant for biochar obtained at lower pyrolytic temperature. However, mineral precipitation mechanism played a crucial role for biochar obtained at high pyrolytic temperature. These results are helpful for the design or screening of "engineered biochar" to act as sorbents to remove or immobilized Cd in polluted soil or water.
Graphical abstract
http://ift.tt/2DeEK2F
Lead, zinc, and cadmium uptake, accumulation, and phytoremediation by plants growing around Tang-e Douzan lead–zinc mine, Iran
Abstract
In the current study, soils of Tang-e Douzan mine, located in Isfahan, Iran, were collected and analyzed for soluble, exchangeable, and total amounts of Pb, Zn, Cd, Ca, and Mg. The maximum Pb, Zn, Cd, Ca, and Mg concentrations in soils were 2500, 1100, 59, 43,800, and 1320 mg/kg for total metals, 86, 83, 6.3, 4650, and 48 mg/kg for their exchangeable fractions, and 59, 3.7, 0.53, 430, and 6.4 mg/kg for their soluble fractions, respectively. All specimens collected, including 69 plant species, were analyzed for Pb, Zn, and Cd. Moreover, their phytoremediation potential was investigated by calculating bioconcentration factors (BCF), translocation factors (TF), and extraction factors (EF) for each heavy metal. Analysis of the leaves for heavy metals showed no metal hyperaccumulation. The highest shoot concentrations of Pb (298 mg/kg) and Zn (740 mg/kg) were found in Roemeria hybrida subsp. dodecandra and Cd (43 mg/kg) in Chenopodium foliosum. Plants having BCFs and TFs > 1 are capable of phytoextraction. Among the analyzed species, four had both TFs and BCFs > 1 for Zn, 13 for Cd, and none for Pb. R. hybrida, Bromus squarrosus, Descurainia sophia, and Poa bulbosa seem to be the best choices for phytoextraction of Zn. Aegilops columnaris, Allium ampeloprasum subsp. iranicum, B. squarrosus, and Cousinia piptocephala are the best choices for phytoextraction of Cd. Plants with BCF > 1 and TF < 1, including Cerastium dichotomum and Muscari neglectum for Pb, Ceratocephala falcata, M. neglectum, Ornithogalum orthophyllum, and Ranunculus arvensis for Zn and C. falcata, M. neglectum, O. orthophyllum, and R. hybrida subsp. dodecandra for Cd, are proposed to be the most efficient species for metal phytostabilization.
http://ift.tt/2DgAW0P
‘Hidden’ occupational allergens such as additives
http://ift.tt/2CMjaS7
Feet in danger: short exposure to contaminated soil causing health damage—an experimental study
Abstract
In this study, hematological and behavioral changes in Wistar rats exposed to soil collected from urban areas next to an industrial complex were investigated. Animals were exposed to soil samples placed at the bottom of cages for 4 days. After this period, behavioral parameters were measured by the open field test and the elevated plus-maze. Blood was collected to measure hematological parameters. The soil from the vicinity of the oil refining industry caused changes in hematological parameters and altered behavioral parameters in both tests. The soil from the vicinity of the petroleum refining industry and fertilizer industries increased the density of white blood cells and decreased exploratory activity in the exposed animals. The results demonstrate that contact with contaminated soils, even for short periods, can cause physiological damage in organisms and that special attention should be given to people who live under constant exposure to these soils.
http://ift.tt/2CYznrA
Contribution of ammonia-oxidizing archaea and ammonia-oxidizing bacteria to ammonia oxidation in two nitrifying reactors
Abstract
In this study, two laboratory nitrifying reactors (NRI and NRII), which were seeded by sludge from different sources and operated under different operating conditions, were found to possess distinct dominant ammonia-oxidizing microorganisms. Ammonia-oxidizing archaeal (AOA) amoA genes outnumbered ammonia-oxidizing bacterial (AOB) amoA genes in reactor NRI, while only AOB amoA genes were detectable in reactor NRII. The AOA amoA gene sequences retrieved from NRI were characterized within the Nitrososphaera sister cluster of the group 1.1b Thaumarchaeota. Two inhibitors for ammonia oxidation, allylthiourea (ATU) and 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO), were applied individually and as a mixture to observe the ammonia-oxidizing activity of both microorganisms in the reactors' sludge. The results indicated that AOA and AOB jointly oxidized ammonia in NRI, while AOB played the main role in ammonia oxidation in NRII. DNA-stable isotope probing with labeled 13C–HCO3− was performed on NRI sludge. Incorporation of 13C into AOA and AOB implied that both microorganisms may perform autotrophy during ammonia oxidation. Taken together, the results from this study provide direct evidence demonstrating the contribution of AOA and AOB to ammonia oxidation in the nitrifying reactors.
http://ift.tt/2ANLSQP
Effect of inorganic and organic solutes on zero-valent aluminum-activated hydrogen peroxide and persulfate oxidation of bisphenol A
Abstract
The effect of varying inorganic (chloride, nitrate, sulfate, and phosphate) and organic (represented by humic acid) solutes on the removal of aqueous micropollutant bisphenol A (BPA; 8.8 μM; 2 mg/L) with the oxidizing agents hydrogen peroxide (HP; 0.25 mM) and persulfate (PS; 0.25 mM) activated using zero-valent aluminum (ZVA) nanoparticles (1 g/L) was investigated at a pH of 3. In the absence of the solutes, the PS/ZVA treatment system was superior to the HP/ZVA system in terms of BPA removal rates and kinetics. Further, the HP/ZVA process was not affected by nitrate (50 mg/L) addition, whereas chloride (250 mg/L) exhibited no effect on the PS/ZVA process. The negative effect of inorganic anions on BPA removal generally speaking increased with increasing charge in the following order: NO3− (no inhibition) < Cl− (250 mg/L) = SO42− < PO43− for HP/ZVA and Cl− (250 mg/L; no inhibition) < NO3− < SO42− < PO43− for PS/ZVA. Upon addition of 20 mg/L humic acid representing natural organic matter, BPA removals decreased from 72 and 100% in the absence of solutes to 24 and 57% for HP/ZVA and PS/ZVA treatments, respectively. The solute mixture containing all inorganic and organic solutes together partly suppressed the inhibitory effects of phosphate and humic acid on BPA removals decreasing to 46 and 43% after HP/ZVA and PS/ZVA treatments, respectively. Dissolved organic carbon removals were obtained in the range of 30 and 47% (the HP/ZVA process), as well as 47 and 57% (the PS/ZVA process) for the experiments in the presence of 20 mg/L humic acid and solute mixture, respectively. The relative Vibrio fischeri photoluminescence inhibition decreased particularly for the PS/ZVA treatment system, which exhibited a higher treatment performance than the HP/ZVA treatment system.
http://ift.tt/2D1oHIU
Association of cord blood ghrelin, leptin and insulin concentrations in term newborns with anthropometric parameters at birth
Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print
http://ift.tt/2ANGXza
EAACI Guidelines on Allergen Immunotherapy – Out With the Old and In With the New
Abstract
Occurring in both developed and developing countries and across all ethnic groups and ages allergic diseases represent a global health problem. During the last few decades, there has been an increase in the prevalence of allergic diseases and it has been predicted that by 2025 half of the entire EU population will be affected [1]. The three major management strategies are avoidance, symptom control by pharmacotherapy and allergen immunotherapy (AIT). By contrast with symptom control by pharmacotherapy AIT aims to modify the immune system via tolerance induction [2] and is potentially able to alter the course of allergic diseases [3]. The potential preventive effect of AIT is currently being explored for pollen [4].
This article is protected by copyright. All rights reserved.
http://ift.tt/2CXX16W
Necessity of interrupted time series analysis in evaluating the impact of PHS risk identification and introduction of direct-acting antiviral therapy and Share 35 implementation
Design, Synthesis and Fungicidal Evaluation of Novel Pyraclostrobin Analogues
Publication date: Available online 10 January 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Lili Wang, Shuangshuang Zhao, Xiaotian Kong, Lingling Cao, Sheng Tian, Yonghao Ye, Chunhua Qiao
A series of novel pyraclostrobin derivatives were designed and prepared as antifungal agents. Their antifungal activities were tested in vitro with five important phytopathogenic fungi, namely, Batrylis cinerea, Phytophthora capsici, Fusarium sulphureum, Gloeosporium pestis and Sclerotinia sclerotiorum using the mycelium growth inhibition method. Among these compounds, 5s displayed IC50 value of 0.57 μg/mL against Batrylis cinerea and 5k-II displayed IC50 value of 0.43 μg/mL against Sclerotinia sclerotiorum, which were close to that of the positive control pyraclostrobin (0.18 μg/mL and 0.15 μg/mL). Other compounds 5f, 5k-II, 5j, 5m and 5s also exhibited strong antifungal activity. Further enzymatic assay demonstrated compound 5s inhibited porcine bc1 complex with IC50 value of 0.95 μM. The statistical results from an integrated computational pipeline demonstrated the predicted total binding free energy for compound 5s is the highest. Consequently, compound 5s with the biphenyl-4-methoxyl side chain could serve as a new motif as inhibitors of bc1 complex and deserve to be further investigated.
Graphical abstract
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Clinical and Pathological Features of Plasma Cell-Rich Acute Rejection after Kidney Transplantation
http://ift.tt/2ALH5zw
Effect of Conversion to CTLA4Ig Treatment on Tacrolimus-Induced Diabetic Rats
http://ift.tt/2D2MF6w
History of marijuana use does not affect outcomes on the liver transplant waitlist
http://ift.tt/2ANGMnJ
Liver transplantation for NASH-related hepatocellular carcinoma versus non-NASH etiologies of hepatocellular carcinoma
http://ift.tt/2CYXqGW
Selective CD28 inhibition modulates alloimmunity and cardiac allograft vasculopathy in anti-CD154-treated monkeys
http://ift.tt/2AObSeL
A high portal venous pressure gradient increases gut-related bacteremia and consequent early mortality after living donor liver transplantation
http://ift.tt/2D2MlEQ
Publication Rates of Oral Abstract Presentations at the 2014 International Congress of the Transplantation Society
Heart Transplantation in a Left Ventricular Assist Device Recipient Following Donor's Extracorporeal Membrane Oxygenation Support: Is it safe?
Patterns of Discordance Between Pretransplant Imaging Stage of Hepatocellular Carcinoma and Posttransplant Pathologic Stage: A Contemporary Appraisal of the Milan Criteria
http://ift.tt/2AMbX2V
The European Society of Regional Anaesthesia and Pain Therapy/American Society of Regional Anesthesia and Pain Medicine Recommendations on Local Anesthetics and Adjuvants Dosage in Pediatric Regional Anesthesia
http://ift.tt/2ANylJd
Epidural Hematoma Following Interlaminar Epidural Injection in Patient Taking Aspirin
http://ift.tt/2CYY4Ed
Macular Ganglion Cell Complex Reduction Preceding Visual Field Loss in a Patient With Chiasmal Compression With a 21-Month Follow-up: Comment
An Evaluation of Educational Neurological Eye Movement Disorder Video Posted on Internet Video Sharing Sites: Comment
Macular Ganglion Cell Complex Reduction Preceding Visual Field Loss in a Patient With Chiasmal Compression With a 21-Month Follow-Up: Response
HINTS in the Acute Vestibular Syndrome: Pearls and Pitfalls
http://ift.tt/2EuYDlD
Management of Morgellons Disease With Low-Dose Trifluoperazine
http://ift.tt/2DhpHpb
Diagnosis of Neurofibromatosis Type 2 From Congenital Skin Plaques
http://ift.tt/2CMAtT3
Intertriginous Condyloma-like Plaques and Ulcers
http://ift.tt/2DgS7j4
Human Herpesvirus 8–Associated Inflammatory Cytokine Syndrome
http://ift.tt/2CRluYd
Comorbidity Development in Children With Psoriasis
http://ift.tt/2Dfuk2O
Allergen Concerns and Popular Skin Care Products
http://ift.tt/2njj9lE
Dermatology Practice Consolidation Fueled by Private Equity Investment
http://ift.tt/2zVEF4m
Dermatology’s Grandest Piano
http://ift.tt/2Dk3XsR
The Importance of Population-Based Estimates of Melanocytic Pathology
http://ift.tt/2z4T1zp
Hair Repigmentation With Anti–PD-1 and Anti–PD-L1 Immunotherapy
http://ift.tt/2jMSX1k
Spanish Fly—Cantharidin’s Alter Ego
http://ift.tt/2DfvWJR
Geographic Distribution of Nonphysicians Who Billed Medicare for Dermatologic Services
http://ift.tt/2jRq9ox
Topical Timolol for Paronychia and Pseudopyogenic Granuloma
http://ift.tt/2yIqD72
Probiotic Strains for Children With Moderate Atopic Dermatitis
http://ift.tt/2m5oMDc
Treatment of Refractory Mycosis Fungoides With Brentuximab Vedotin
http://ift.tt/2jMkkZj
Factors Associated With Remission of Skin Disease in Dermatomyositis
http://ift.tt/2AgVAeH
Hair Repigmentation With Anti–PD-1 and Anti–PD-L1 Immunotherapy—Reply
http://ift.tt/2hU43AZ
Preference-Based QOL Measures for Economic Evaluations in Early Melanoma
http://ift.tt/2zBoM03
Error in Figure Legend
http://ift.tt/2DjIznu
Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients
http://ift.tt/2hW3C9v
Sporty Spots
http://ift.tt/2DjImkc
Operative Behandlungsoptionen bei Hidradenitis suppurativa/Acne inversa
Zusammenfassung
Hidradenitis suppurativa/Acne inversa (HS/AI) ist eine chronisch inflammatorische Hauterkrankung, für deren Behandlung konservative und operative Therapieoptionen zur Verfügung stehen. Im Hurley-Stadium II und III stellt die operative Sanierung von irreversibel destruiertem Gewebe die Methode der Wahl dar. Resektionstechniken unterschiedlicher Invasivität werden in der Literatur beschrieben. Bisher herrscht kein allgemein akzeptierter Konsens über den Einsatz verschiedener Resektions- und Rekonstruktionstechniken sowie die postoperative Nachbehandlung. Die Beurteilung von Rezidiven nach chirurgischer Intervention wird durch fehlende Rezidivdefinitionen sowie eine heterogene Studienlage erschwert.
http://ift.tt/2mnl6u9
Performance of ceramic ultrafiltration and reverse osmosis membranes in treating car wash wastewater for reuse
Abstract
Reusing treated effluents in industries is a great option to conserve freshwater resources. For example, car wash centres all over Australia are estimated to use 17.5 billion litres of water and discharge it as wastewater and spend $75 million a year for both purchasing fresh water and for treating and/or discharging the wastewater. Therefore, it is important to develop simple but reliable systems that can help to treat and reuse car wash wastewater. Significant savings could also be associated with the implementation of such systems. This study evaluates the performance of granular and membrane filtration systems with coagulation/flocculation and sedimentation in treating car wash wastewater for the purpose of reuse. Overall, 99.9% of turbidity, 100% of suspended solids and 96% of COD were removed from the car wash wastewater after treating by coagulation, flocculation, sedimentation, sand filtration, ceramic ultrafiltration and reverse osmosis and the treated water meets the standards required for class A recycled water in Australia and standards imposed in Belgium and China. The treated water can be reused. However, optimisation is required to reduce the sludge produced by this system.
http://ift.tt/2ANAfJx
Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example
Abstract
Toxicological studies use "specialty chemicals" and, thus, should assess and report both identity and degree of purity (homogeneity) of the chemicals (or toxicants) under investigation to ensure that other scientists can replicate experimental results. Although detailed reporting criteria for the synthesis and characterization of organic compounds have been established by organic chemistry journals, such criteria are inconsistently applied to the chemicals used in toxicological studies. Biologically active trace impurities may lead to incorrect conclusions about the chemical entity responsible for a biological response, which in turn may confound risk assessment. Based on our experience with the synthesis of PCBs and their metabolites, we herein propose guidelines for the "authentication" of synthetic PCBs and, by extension, other organic toxicants, and provide a checklist for documenting the authentication of toxicants reported in the peer-reviewed literature. The objective is to expand guidelines proposed for different types of biomedical and preclinical studies to include a thorough authentication of specialty chemicals, such as PCBs and their derivatives, with the goal of ensuring transparent and open reporting of scientific results in toxicology and the environmental health sciences.
http://ift.tt/2CNifko
Identification and functional characterization of type II toxin/antitoxin systems in Aggregatibacter actinomycetemcomitans
Summary
Type II toxin/antitoxin (TA) systems contribute to the formation of persister cells and biofilm formation for many organisms. A. actinomycetemcomitans thrives in the complex oral microbial community subjected to continual environmental flux. Little is known regarding the presence and function of type II TA systems in this organism or their contribution to adaptation and persistence in the biofilm. We identified 11 TA systems that are conserved across all seven serotypes of A. actinomycetemcomitans and represent the RelBE, MazEF and HipAB families of type II TA systems. The systems selectively responded to various environmental conditions that exist in the oral cavity. Two putative RelBE-like TA systems, D11S_1194-1195 and D11S_1718-1719 were induced in response to low pH and deletion of D11S_1718-1719 significantly reduced metabolic activity of stationary phase A. actinomycetemcomitans cells upon prolonged exposure to acidic conditions. The deletion mutant also exhibited reduced biofilm biomass when cultured under acidic conditions. The D11S_1194 and D11S_1718 toxin proteins inhibited in vitro translation of dihydrofolate reductase (DHFR) and degraded ribosome-associated but not free MS2 virus RNA. In contrast, the corresponding antitoxins (D11S_1195 and D11S_1719), or equimolar mixtures of toxin and antitoxin had no effect on DHFR production or RNA degradation. Together, these results suggest that D11S_1194-1195 and D11S_1718-1719 are RelBE-like type II TA systems that are activated under acidic conditions and may function to cleave ribosome-associated mRNA to inhibit translation in A. actinomycetemcomitans. In vivo, these systems may facilitate A. actinomycetemcomitans adaptation and persistence in acidic local environments in the dental biofilm.
This article is protected by copyright. All rights reserved.
http://ift.tt/2mgfEZb
Evaluation of the Thyroid Volume After Radiofrequency Ablation of Thyroid Nodules and Recurrent Thyroid
Intervention: Device: Celon Pro Surge
Sponsor: Olympus Surgical Technologies Europe
Recruiting
http://ift.tt/2AM3H2N
Avenir® Cemented Hip Stem - PMCF
Intervention:
Sponsor: Zimmer Biomet
Recruiting
http://ift.tt/2D0EYNY
Evaluation of the Thyroid Volume After Radiofrequency Ablation of Thyroid Nodules and Recurrent Thyroid
Intervention: Device: Celon Pro Surge
Sponsor: Olympus Surgical Technologies Europe
Recruiting
http://ift.tt/2AM3H2N
Avenir® Cemented Hip Stem - PMCF
Intervention:
Sponsor: Zimmer Biomet
Recruiting
http://ift.tt/2D0EYNY
The Association Between Serum Vaspin and Omentin-1 Levels in Obese Children with Metabolic Syndrome
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0.
http://ift.tt/2D0KHTc
In Vivo and Ex Vivo Inflammatory Markers of Common Metabolic Phenotypes in Humans
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0.
http://ift.tt/2mgRL3T
Interaction of Metabolic Health and Obesity on Subclinical Target Organ Damage
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0.
http://ift.tt/2D0p9Gn
Head circumference - a useful single parameter for skull volume development in cranial growth analysis?
Abstract
Background
The measurement of maximal head circumference is a standard procedure in the examination of childrens' cranial growth and brain development. The objective of the study was to evaluate the validity of maximal head circumference to cranial volume in the first year of life using a new method which includes ear-to-ear over the head distance and maximal cranial length measurement.
Methods
3D surface scans for cranial volume assessment were conducted in this method comparison study of 44 healthy Caucasian children (29 male, 15 female) at the ages of 4 and 12 months.
Results
Cranial volume increased from measurements made at 4 months to 12 months of age by an average of 1174 ± 106 to 1579 ± 79 ml. Maximal cranial circumference increased from 43.4 ± 9 cm to 46.9 ± 7 cm and the ear-to ear measurement increased from 26.3 ± 21 cm to 31.6 ± 18 cm at the same time points. There was a monotone association between maximal head circumference (HC) and increase in volume, yet a backwards inference from maximal circumference to the volume had a predictive value of only 78% (adjusted R2). Including the additional measurement of distance from ear to ear strengthened the ability of the model to predict the true value attained to 90%. The addition of the parameter skull length appeared to be negligible.
Conclusion
The results demonstrate that for a distinct improvement in the evaluation of a physiological cranial volume development, the additional measurement of the ear-to ear distance using a measuring tape is expedient, and, especially for cases with pathological skull changes, such as craniosynostosis, ought to be conducted.
http://ift.tt/2CVnRwp
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- Diagnosis of Neurofibromatosis Type 2 From Congeni...
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- Comorbidity Development in Children With Psoriasis
- Allergen Concerns and Popular Skin Care Products
- Dermatology Practice Consolidation Fueled by Priva...
- Dermatology’s Grandest Piano
- The Importance of Population-Based Estimates of Me...
- Hair Repigmentation With Anti–PD-1 and Anti–PD-L1 ...
- Spanish Fly—Cantharidin’s Alter Ego
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- Probiotic Strains for Children With Moderate Atopi...
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