Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway

Objective. Shikonin possesses anti-inflammatory effects. However, its function in concanavalin A-induced acute liver injury remains uncertain. The aim of the present study was to investigate the functions of shikonin and its mechanism of protection on ConA-induced acute liver injury. Materials and Methods. Balb/C mice were exposed to ConA (20 mg/kg) via tail vein injection to establish acute liver injury; shikonin (7.5 mg/kg and 12.5 mg/kg) was intraperitoneally administered 2 h before the ConA injection. The serum liver enzyme levels and the inflammatory cytokine levels were determined at 3, 6, and 24 h after ConA injection. Results. After the injection of ConA, inflammatory cytokines IL-1β, TNF-α, and IFN-γ were significantly increased. Shikonin significantly ameliorated liver injury and histopathological changes and suppressed the release of inflammatory cytokines. The expressions of Bcl-2 and Bax were markedly affected by shikonin pretreatment. LC3, Beclin-1, and p-JNK expression levels were decreased in the shikonin-pretreated groups compared with the ConA-treated groups. Shikonin attenuated ConA-induced liver injury by reducing apoptosis and autophagy through the inhibition of the JNK pathway. Conclusion. Our results indicated that shikonin pretreatment attenuates ConA-induced acute liver injury by inhibiting apoptosis and autophagy through the suppression of the JNK pathway.

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Coping with suicidal urges among youth seen in a psychiatric emergency department

Psychiatry Research

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Late Toxicities of Intensity-Modulated Radiation Therapy for Head and Neck Rhabdomyosarcoma

Purpose/objectives

To examine the late effects of intensity-modulated radiation therapy (IMRT) in pediatric patients with rhabdomyosarcoma of the head and neck.

Materials/methods

All 1-year survivors of pediatric head and neck rhabdomyosarcoma treated with IMRT at a single institution from 1999 to 2014 were assessed for long-term complications. Late toxicities were graded according to CTCAE version 4.03.

Results

Among 30 patients, median age at IMRT was 7.4 (1.5–20.8) years, median follow-up was 7.7 (1.2–14.4) years, and median IMRT dose was 50.4 (36–50.4) Gy. Tumor subsites included parameningeal (80%), orbit (13%), and other (7%). Common late toxicities were facial disfigurement (n = 23, 77%), growth hormone deficiency (n = 11, 37%), cataract (n = 10, 34%), and dental problems (n = 10, 33%). Twenty-two patients (73%) had ≥2 late toxicities and 14 patients (47%) had ≥3 late toxicities. Seventeen patients (57%) experienced grade 2 toxicity and 10 patients (33%) had grade 3 toxicity. Grade 3 toxicities included visual disturbance, cataract, facial disfigurement, chronic sinusitis/otitis, and hearing loss. Severe facial deformity was noted in nine patients (30%), and three patients underwent cosmetic surgery. Patients with severe facial deformity were treated at younger ages (median 6.0 years vs. 8.1 years for patients with no/nonsevere facial deformity) and more likely to have infratemporal fossa tumors. There were no secondary solid malignancies.

Conclusions

Late radiation toxicities are common in survivors of pediatric head and neck rhabdomyosarcoma treated with IMRT. While the majority of late effects are mild–moderate, they can significantly impact quality of life, particularly facial disfigurement.

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Is Extended Sedation Necessary for Young Children Receiving High-Dose 131I-MIBG Therapy?

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Coombs Positive Thrombotic Thrombocytopenic Purpura in a Male Pediatric Patient: An Urgent Diagnostic Challenge

Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy often caused by deficiency of von Willebrand (vW) factor cleaving protease, ADAMTS-13, leading to large vW multimers and intravascular platelet aggregation. Hemolysis in TTP is mechanical and nonimmune mediated, thus Coombs testing is usually negative. We report a case of an adolescent with thrombocytopenia and Coombs positive anemia, diagnosed with Evans syndrome, but ultimately found to have TTP. TTP should be considered in children with thrombocytopenia and Coombs positive anemia who are refractory to steroids or develop signs of microangiopathy.  Recognition of this presentation can lead to life-saving treatment with plasma exchange.

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Higher Gemcitabine Dose Was Associated With Better Outcome of Osteosarcoma Patients Receiving Gemcitabine-Docetaxel Chemotherapy

ABSTRACT

Background

Efficacy of gemcitabine and docetaxel (GEM + DOC) chemotherapy in patients with recurrent or refractory osteosarcoma was evaluated.

Methods

Data of 53 patients from 9 institutions, who received GEM (675 or 900 mg/m² on days 1 and 8) and DOC (100 mg/m² on day 8), were retrospectively reviewed.

Results

GEM + DOC was administered as adjuvant (n = 25) or palliative chemotherapy (n = 28). Patients received a median 3 courses (range, 1−10 courses). Objective response rate (CR + PR, where CR is complete response and PR is partial response) and disease control rate (CR+ PR + SD, where SD is stable disease) were 14.3% and 28.6%, respectively. Disease control rate was higher in patients receiving 900 mg/m² GEM than in patients receiving 675 mg/m² (50.0% vs. 12.5%, P = 0.03). Higher GEM dose was associated with better survival, both in adjuvant (1-year overall survival, 90.9 ± 8.7% vs. 38.5 ± 13.5%, P = 0.002) and palliative settings (50.0 ± 14.4% vs. 31.3 ± 11.6%, P = 0.04).

Conclusions

Further studies are necessary to investigate the efficacy of more aggressive and higher doses of GEM + DOC chemotherapy in osteosarcoma.

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Price and affordability of direct-acting antiviral regimens for hepatitis C virus in the United States

Abstract

Hepatitis C virus is a serious infection causing cirrhosis, liver cancer, and death. The recent development of direct-acting antivirals has dramatically improved tolerability of treatment and rates of cure. However, the high price of these medications has often limited access to care and resulted in rationing of medications in the United States to those with advanced liver disease, access to specialist care, and without active substance use. This review assesses the way pharmaceutical prices are established and how pricing of directly acting antiviral regimens in the United States has impacted access to treatment for hepatitis C virus.

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Cellular immune response to hepatitis-C-virus in subjects without viremia or seroconversion: is it important?

Abstract

Hepatitis C Virus (HCV) causes chronic infection and represents a global health burden. To date, there is no licensed vaccine for HCV. The high viral replication rate and the existence of several HCV genotypes and quasispecies hamper the development of an effective universal vaccine. In this regard, the current HCV vaccine candidates show genotype-specific protection or narrow cross reactivity against other genotypes. Importantly, HCV spontaneous clearance occurs in 15–50 % of infected subjects, indicating that natural resistance to chronic infection exists. This phenomenon was demonstrated among humans and chimpanzees and continues to motivate researchers attempting to develop an effective HCV vaccine. However, what constitutes a protective immune response or correlate of protection against HCV infection is still vague. Additionally, the mechanisms behind successful HCV clearance suggest the coordination of several arms of the immune system, with cell-mediated immunity (CMI) playing a crucial role in this process. By contrast, although neutralizing antibodies have been identified, they are isolate-specific and poorly correlate with viral clearance. Antigen-specific CD4 T cells, instead, correlate with transient decline in HCV viremia and long-lasting control of the infection. Unfortunately, HCV has been very successful in evading host immune mechanisms, leading to complications such as liver fibrosis, cirrhosis and hepatocellular carcinoma. Interestingly, CMI to HCV antigens were shown among exposed individuals without viremia or seroconversion, suggesting the clearance of prior HCV infection(s). These individuals include family members living with HCV-infected subjects, healthcare workers, IV drug users, and sexual contacts. The correlates of protection could be closely monitored among these individuals. This review provides a summary of HCV-specific immune responses in general and of CMI in particular in these cohorts. The importance of these CMI responses are discussed.

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Intimacy after prostate cancer: A brief couples' workshop is associated with improvements in relationship satisfaction

Abstract

Objective

Prostate cancer (PCa) treatments often leave men with erectile dysfunction (ED). Even when ED treatments are effective in restoring men's ability to have an erection sufficient for intercourse, couples continue to struggle sexually. Effective treatments to help couples recover sexually are needed.

Method

PCa patients and partners (N = 59 couples) attending a one-time couples' intimacy workshop, participated in an evaluation. The workshop, offered eight times over a 2-year period, emphasized a couples-based approach to treatment that enhances direct communication about sexuality and implementation of sexual recovery strategies that are consistent with the couple's values. Couples completed pre and post questionnaires (at baseline and 2 months later) assessing the primary outcome of relationship adjustment (Revised Dyadic Adjustment Scale) and secondary outcome of sexual function (Sexual Function Questionnaire). T-tests were employed to examine pre-post changes in scores. A small qualitative sub-study was conducted on the use of a Commitment to Change goal-setting exercise, completed during the workshop.

Results

Results provide insight into the specific nature of improvements. Patients and partners showed improvements in relationship satisfaction. Improvements with small-to-medium effect sizes were observed for patients and partners sexual function; however, after adjusting for multiple comparisons, these changes were no longer statistically significant. The specific goals set by couples, and their achievement status, are presented.

Conclusions

The workshop offers a comprehensive, one-session intervention to help couples implement a treatment plan to promote sexual recovery after PCa treatment. Given the observed improvements, progression to a randomized control trial is warranted. Copyright © 2016 John Wiley & Sons, Ltd.

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Assessing depression in a geriatric cancer population

Abstract

Objective

To examine the ability of three popular self-report measures of depression to assess depression in a geriatric cancer setting.

Method

Cancer patients 70 years or older and on active treatment completed the Geriatric Depression Scale-Short Form, the Hospital Anxiety and Depression Scale, and the Center for Epidemiological Studies Depression Scale—Revised, and were interviewed using the depression module of the Structured Clinical Interview for DSM disorders (SCID) as the 'gold standard.' Analyses included calculating internal consistency, ROC curves, and the sensitivity and specificity to detect major depression (MDD) or minor depression (i.e. subthreshold depression).

Results

In a sample of 201 cancer patients (85% White; 64% completed college degree or higher), all three of the self-report measures produced adequate internal consistency and predicted depression greater than chance. However, the published cutoff scores for detecting MDD produced inadequate sensitivity, suggesting these scores will miss as many as 33%–83% of geriatric cancer patients who are depressed. Revised cutoff scores were lower than published cutoff scores.

Conclusion

Although these measures produced good internal consistency and were better than chance at predicting depression in a geriatric cancer sample, the published cutoff scores for these measures did not perform well in predicting MDD nor minor depression. Of the three measures, the CES-D appeared to have the most utility. This data suggests that these popular screening measures may be inadequate for reliably identifying depression in a geriatric cancer population. Researchers and clinicians, therefore, should use caution when selecting depression measures for geriatric cancer patients and consider using the lower cut-off scores presented here. Copyright © 2016 John Wiley & Sons, Ltd.

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Spiritual well-being and spiritual distress predict adjustment in adolescent and young adult cancer survivors

Abstract

Objective

Spirituality is related to many aspects of cancer survivors' physical and psychological adjustment. Given their unique developmental issues, spiritual issues may be especially important to adolescent and young adult (AYA) survivors, yet little research has been conducted on spirituality with AYA survivors. The present study examines how two aspects of spirituality, spiritual well-being (comprising faith and meaning/peace), and spiritual struggle relate to later post-cancer adjustment.

Methods

At Time 1 (T1), 120 AYA survivors completed questionnaires on spirituality and adjustment (fear of recurrence, post-traumatic stress symptoms, perceived post-traumatic growth, psychological distress, and health-related quality of life). Eighty-three of these participants also completed these questionnaires at Time 2 (T2), one year later.

Results

Our sample reported fairly low spiritual well-being (meaning/peace, faith) and spiritual struggle. As expected, T1 spiritual well-being was positively correlated with some aspects of psychological adjustment at T2, whereas T1 spiritual struggle was inversely correlated with T2 psychological adjustment. Both dimensions of T1 spiritual well-being, but not struggle, were positively associated with perceived T2 posttraumatic growth. In general, T1 spiritual well-being and struggle correlated with T2 psychological adjustment even when demographics and cancer-related variables were controlled.

Conclusions

These results suggest that while spirituality is not important to all AYA survivors, both spiritual well-being and struggle have important associations with adjustment and may warrant clinical attention. Future research is needed to more fully understand the role of spirituality in AYA survivors' adjustment in more depth. Copyright © 2016 John Wiley & Sons, Ltd.

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Coping and resiliency enhancement program (CARE): a pilot study for interpreters in cancer care

Abstract

Objective

There is a growing demand for interpreters in the cancer setting. Interpreters, the link to quality care for limited English proficiency patients, face many psychosocial stressors in their work. This project assessed interpreters' experiences of stress and piloted a resiliency program to help interpreters cope with stressors.

Methods

From 2013 to 2014, we pilot tested a targeted resiliency program with interpreters from three Boston-based hospitals. In Phase 1, we conducted five focus groups (n = 31) to identify interpreters' psychosocial needs. In Phase 2, we developed and tested a 4-h group program with 29 interpreters (response rate = 90%; 69% female, 54% Hispanic, 85% born outside of the U.S.).

Results

Phase 1. Stressors were patient-based (seeing young patients decline), interactions with medical team (unsure of role), and systems-based (appointment unpredictability). Phase 2. At baseline interpreters reported low abilities to cope with stress (measured by the Measure of Current Status (MOCS-A)). At 4-week follow-up we found improvements in job satisfaction (p = .02; Cohen's d = .41) and declines in sick days (p = .08; Cohen's d = .38). Stress reactivity (MOCS-A) improved; specifically participants reported feeling more assertive about their needs (p = .10; Cohen's d = .30) and more able to relax at will (p = .10; Cohen's d = .35)—important mechanisms to lower distress.

Conclusions

We piloted a resiliency program for medical interpreters in cancer care. We found that interpreters experience distress and have low coping skills. This program resulted in improved work factors and stress reactivity. Future research should include further implementation and testing in a larger, randomized trial. Copyright © 2016 John Wiley & Sons, Ltd.

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Oncology and medical education—past, present and future

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Prevalence of obesity in Chambal region and predictors of risk factors

2016-05-16T04-45-42Z
Source: International Journal of Advances in Medicine
Sushma Trikha, Neelima Singh.
Background: The prevalence of obesity is alarmingly high, affecting both developed and developing countries of all socio-economic groups, irrespective of age, sex or ethnicity. As the prevalence of obesity increases so does the burden of its associated co-morbidities. The purpose of this study was to evaluate the prevalences of overweight and obesity in our region, study the association between family history of diabetes (FHD) and body mass index (BMI) and to assess the relationship between family history of obesity and body mass index (BMI). Methods: A cross sectional population based study of 1017 randomly selected individuals was conducted. Pregnant patients and those with hypothyroidism, severe disability or severe psychiatric disturbance were excluded. Study included school going children, college going students, employees of medical college GRMC Gwalior and attendants of indoor and outdoor patients. Weight and height were measured and body mass index calculated. Patients with BMI > 23 kg/m2 were defined as overweight and those with BMI 27.5 kg/m2 and above were labelled as obese as per the WHO recommendation for Asian population. Results: A total of 1017 patients were included in this study. There were 573 (56.34%) males and 444(43.66 %) females. Overall prevalence of overweight was 251(24.6%) and prevalence of obesity was (25) 2.4%. 93 (33.69%) of those with BMI >23 had family history of obesity while the figure was 81 (10.93%) in those with BMI 23 had family history of diabetes and 40 (5.39%) with BMI 23 consumed alcohol compared to 11 (7.5%) cases with BMI


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A role for loop G in the β1 strand in GABAA receptor activation

The GABA_A receptor α subunit β1 strand runs anti-parallel to the β2 strand, which contains loop D, known to participate in receptor activation and agonist binding. However, a role for the β1 strand has yet to be established. We used molecular dynamics simulation to quantify the solvent accessible surface area (SASA) of β1 strand residues in the GABA_A β3 homopentamer structure. Residues in the complementary interface equivalent to those between Asp43 and Thr47 in the a1 subunit have an alternating pattern of high and low SASA consistent with a β strand structure. We investigated the functional role of these β1 strand residues in the α1 subunit by individually replacing them with Cys residues. D43C and T47C substitutions reduced the apparent potency of GABA at α1β2γ2 receptors by around 50-fold and 8-fold, respectively, whereas the F45C substitution caused a biphasic GABA concentration-response relationship and increased spontaneous gating. Receptors with D43C or T47C substitutions were sensitive to MTSEA modification. However, GABA-evoked currents mediated by α1(F45C)β2γ2 receptors were unaffected by MTSEA, suggesting that this residue is inaccessible. Both GABA and the allosteric agonist propofol reduced MTSEA modification of α1(D43C)β2γ2 and α1(T47C)β2γ2 receptors indicating movement of the β1 strand even during allosteric activation. This is in contrast to α1(F64C)β2γ2 receptors where only GABA, but not propofol reduced MTSEA modification. These findings provide the first functional evidence for movement of the β1 strand during gating of the receptor and identify residues that are critical for maintaining GABA_A receptor function.

This article is protected by copyright. All rights reserved

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A Thermoresponsive Poly(Ionic Liquid) Membrane Enables Concentration of Proteins from Aqueous Media

Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6CC02703B, Communication

Yuki Kohno, Douglas Gin, Richard D Noble, Hiroyuki Ohno
A chemically cross-linked, sufficiently hydrated poly(ionic liquid) membrane shows switchable hydrated states via lower critical solution temperature-type phase behaviour. This enables concentration of a few water-soluble proteins from aqueous media...
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Cooperative Organocatalysis of Mukaiyama-Type Aldol Reactions by Thioureas and Nitro Compounds

Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6CC01984F, Communication

Konstantin Bukhryakov, Victor Desyatkin, Valentin Rodionov
A unique organocatalytic system for Mukaiyama-type aldol reactions based on the cooperative action of nitro compounds and thioureas has been identified. This system is compatible with a wide range of...
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Late Toxicities of Intensity-Modulated Radiation Therapy for Head and Neck Rhabdomyosarcoma

Purpose/objectives

To examine the late effects of intensity-modulated radiation therapy (IMRT) in pediatric patients with rhabdomyosarcoma of the head and neck.

Materials/methods

All 1-year survivors of pediatric head and neck rhabdomyosarcoma treated with IMRT at a single institution from 1999 to 2014 were assessed for long-term complications. Late toxicities were graded according to CTCAE version 4.03.

Results

Among 30 patients, median age at IMRT was 7.4 (1.5–20.8) years, median follow-up was 7.7 (1.2–14.4) years, and median IMRT dose was 50.4 (36–50.4) Gy. Tumor subsites included parameningeal (80%), orbit (13%), and other (7%). Common late toxicities were facial disfigurement (n = 23, 77%), growth hormone deficiency (n = 11, 37%), cataract (n = 10, 34%), and dental problems (n = 10, 33%). Twenty-two patients (73%) had ≥2 late toxicities and 14 patients (47%) had ≥3 late toxicities. Seventeen patients (57%) experienced grade 2 toxicity and 10 patients (33%) had grade 3 toxicity. Grade 3 toxicities included visual disturbance, cataract, facial disfigurement, chronic sinusitis/otitis, and hearing loss. Severe facial deformity was noted in nine patients (30%), and three patients underwent cosmetic surgery. Patients with severe facial deformity were treated at younger ages (median 6.0 years vs. 8.1 years for patients with no/nonsevere facial deformity) and more likely to have infratemporal fossa tumors. There were no secondary solid malignancies.

Conclusions

Late radiation toxicities are common in survivors of pediatric head and neck rhabdomyosarcoma treated with IMRT. While the majority of late effects are mild–moderate, they can significantly impact quality of life, particularly facial disfigurement.

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Is Extended Sedation Necessary for Young Children Receiving High-Dose 131I-MIBG Therapy?

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Coombs Positive Thrombotic Thrombocytopenic Purpura in a Male Pediatric Patient: An Urgent Diagnostic Challenge

Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy often caused by deficiency of von Willebrand (vW) factor cleaving protease, ADAMTS-13, leading to large vW multimers and intravascular platelet aggregation. Hemolysis in TTP is mechanical and nonimmune mediated, thus Coombs testing is usually negative. We report a case of an adolescent with thrombocytopenia and Coombs positive anemia, diagnosed with Evans syndrome, but ultimately found to have TTP. TTP should be considered in children with thrombocytopenia and Coombs positive anemia who are refractory to steroids or develop signs of microangiopathy.  Recognition of this presentation can lead to life-saving treatment with plasma exchange.

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Higher Gemcitabine Dose Was Associated With Better Outcome of Osteosarcoma Patients Receiving Gemcitabine-Docetaxel Chemotherapy

ABSTRACT

Background

Efficacy of gemcitabine and docetaxel (GEM + DOC) chemotherapy in patients with recurrent or refractory osteosarcoma was evaluated.

Methods

Data of 53 patients from 9 institutions, who received GEM (675 or 900 mg/m² on days 1 and 8) and DOC (100 mg/m² on day 8), were retrospectively reviewed.

Results

GEM + DOC was administered as adjuvant (n = 25) or palliative chemotherapy (n = 28). Patients received a median 3 courses (range, 1−10 courses). Objective response rate (CR + PR, where CR is complete response and PR is partial response) and disease control rate (CR+ PR + SD, where SD is stable disease) were 14.3% and 28.6%, respectively. Disease control rate was higher in patients receiving 900 mg/m² GEM than in patients receiving 675 mg/m² (50.0% vs. 12.5%, P = 0.03). Higher GEM dose was associated with better survival, both in adjuvant (1-year overall survival, 90.9 ± 8.7% vs. 38.5 ± 13.5%, P = 0.002) and palliative settings (50.0 ± 14.4% vs. 31.3 ± 11.6%, P = 0.04).

Conclusions

Further studies are necessary to investigate the efficacy of more aggressive and higher doses of GEM + DOC chemotherapy in osteosarcoma.

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Price and affordability of direct-acting antiviral regimens for hepatitis C virus in the United States

Abstract

Hepatitis C virus is a serious infection causing cirrhosis, liver cancer, and death. The recent development of direct-acting antivirals has dramatically improved tolerability of treatment and rates of cure. However, the high price of these medications has often limited access to care and resulted in rationing of medications in the United States to those with advanced liver disease, access to specialist care, and without active substance use. This review assesses the way pharmaceutical prices are established and how pricing of directly acting antiviral regimens in the United States has impacted access to treatment for hepatitis C virus.

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Cellular immune response to hepatitis-C-virus in subjects without viremia or seroconversion: is it important?

Abstract

Hepatitis C Virus (HCV) causes chronic infection and represents a global health burden. To date, there is no licensed vaccine for HCV. The high viral replication rate and the existence of several HCV genotypes and quasispecies hamper the development of an effective universal vaccine. In this regard, the current HCV vaccine candidates show genotype-specific protection or narrow cross reactivity against other genotypes. Importantly, HCV spontaneous clearance occurs in 15–50 % of infected subjects, indicating that natural resistance to chronic infection exists. This phenomenon was demonstrated among humans and chimpanzees and continues to motivate researchers attempting to develop an effective HCV vaccine. However, what constitutes a protective immune response or correlate of protection against HCV infection is still vague. Additionally, the mechanisms behind successful HCV clearance suggest the coordination of several arms of the immune system, with cell-mediated immunity (CMI) playing a crucial role in this process. By contrast, although neutralizing antibodies have been identified, they are isolate-specific and poorly correlate with viral clearance. Antigen-specific CD4 T cells, instead, correlate with transient decline in HCV viremia and long-lasting control of the infection. Unfortunately, HCV has been very successful in evading host immune mechanisms, leading to complications such as liver fibrosis, cirrhosis and hepatocellular carcinoma. Interestingly, CMI to HCV antigens were shown among exposed individuals without viremia or seroconversion, suggesting the clearance of prior HCV infection(s). These individuals include family members living with HCV-infected subjects, healthcare workers, IV drug users, and sexual contacts. The correlates of protection could be closely monitored among these individuals. This review provides a summary of HCV-specific immune responses in general and of CMI in particular in these cohorts. The importance of these CMI responses are discussed.

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Intimacy after prostate cancer: A brief couples' workshop is associated with improvements in relationship satisfaction

Abstract

Objective

Prostate cancer (PCa) treatments often leave men with erectile dysfunction (ED). Even when ED treatments are effective in restoring men's ability to have an erection sufficient for intercourse, couples continue to struggle sexually. Effective treatments to help couples recover sexually are needed.

Method

PCa patients and partners (N = 59 couples) attending a one-time couples' intimacy workshop, participated in an evaluation. The workshop, offered eight times over a 2-year period, emphasized a couples-based approach to treatment that enhances direct communication about sexuality and implementation of sexual recovery strategies that are consistent with the couple's values. Couples completed pre and post questionnaires (at baseline and 2 months later) assessing the primary outcome of relationship adjustment (Revised Dyadic Adjustment Scale) and secondary outcome of sexual function (Sexual Function Questionnaire). T-tests were employed to examine pre-post changes in scores. A small qualitative sub-study was conducted on the use of a Commitment to Change goal-setting exercise, completed during the workshop.

Results

Results provide insight into the specific nature of improvements. Patients and partners showed improvements in relationship satisfaction. Improvements with small-to-medium effect sizes were observed for patients and partners sexual function; however, after adjusting for multiple comparisons, these changes were no longer statistically significant. The specific goals set by couples, and their achievement status, are presented.

Conclusions

The workshop offers a comprehensive, one-session intervention to help couples implement a treatment plan to promote sexual recovery after PCa treatment. Given the observed improvements, progression to a randomized control trial is warranted. Copyright © 2016 John Wiley & Sons, Ltd.

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Assessing depression in a geriatric cancer population

Abstract

Objective

To examine the ability of three popular self-report measures of depression to assess depression in a geriatric cancer setting.

Method

Cancer patients 70 years or older and on active treatment completed the Geriatric Depression Scale-Short Form, the Hospital Anxiety and Depression Scale, and the Center for Epidemiological Studies Depression Scale—Revised, and were interviewed using the depression module of the Structured Clinical Interview for DSM disorders (SCID) as the 'gold standard.' Analyses included calculating internal consistency, ROC curves, and the sensitivity and specificity to detect major depression (MDD) or minor depression (i.e. subthreshold depression).

Results

In a sample of 201 cancer patients (85% White; 64% completed college degree or higher), all three of the self-report measures produced adequate internal consistency and predicted depression greater than chance. However, the published cutoff scores for detecting MDD produced inadequate sensitivity, suggesting these scores will miss as many as 33%–83% of geriatric cancer patients who are depressed. Revised cutoff scores were lower than published cutoff scores.

Conclusion

Although these measures produced good internal consistency and were better than chance at predicting depression in a geriatric cancer sample, the published cutoff scores for these measures did not perform well in predicting MDD nor minor depression. Of the three measures, the CES-D appeared to have the most utility. This data suggests that these popular screening measures may be inadequate for reliably identifying depression in a geriatric cancer population. Researchers and clinicians, therefore, should use caution when selecting depression measures for geriatric cancer patients and consider using the lower cut-off scores presented here. Copyright © 2016 John Wiley & Sons, Ltd.

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Spiritual well-being and spiritual distress predict adjustment in adolescent and young adult cancer survivors

Abstract

Objective

Spirituality is related to many aspects of cancer survivors' physical and psychological adjustment. Given their unique developmental issues, spiritual issues may be especially important to adolescent and young adult (AYA) survivors, yet little research has been conducted on spirituality with AYA survivors. The present study examines how two aspects of spirituality, spiritual well-being (comprising faith and meaning/peace), and spiritual struggle relate to later post-cancer adjustment.

Methods

At Time 1 (T1), 120 AYA survivors completed questionnaires on spirituality and adjustment (fear of recurrence, post-traumatic stress symptoms, perceived post-traumatic growth, psychological distress, and health-related quality of life). Eighty-three of these participants also completed these questionnaires at Time 2 (T2), one year later.

Results

Our sample reported fairly low spiritual well-being (meaning/peace, faith) and spiritual struggle. As expected, T1 spiritual well-being was positively correlated with some aspects of psychological adjustment at T2, whereas T1 spiritual struggle was inversely correlated with T2 psychological adjustment. Both dimensions of T1 spiritual well-being, but not struggle, were positively associated with perceived T2 posttraumatic growth. In general, T1 spiritual well-being and struggle correlated with T2 psychological adjustment even when demographics and cancer-related variables were controlled.

Conclusions

These results suggest that while spirituality is not important to all AYA survivors, both spiritual well-being and struggle have important associations with adjustment and may warrant clinical attention. Future research is needed to more fully understand the role of spirituality in AYA survivors' adjustment in more depth. Copyright © 2016 John Wiley & Sons, Ltd.

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Coping and resiliency enhancement program (CARE): a pilot study for interpreters in cancer care

Abstract

Objective

There is a growing demand for interpreters in the cancer setting. Interpreters, the link to quality care for limited English proficiency patients, face many psychosocial stressors in their work. This project assessed interpreters' experiences of stress and piloted a resiliency program to help interpreters cope with stressors.

Methods

From 2013 to 2014, we pilot tested a targeted resiliency program with interpreters from three Boston-based hospitals. In Phase 1, we conducted five focus groups (n = 31) to identify interpreters' psychosocial needs. In Phase 2, we developed and tested a 4-h group program with 29 interpreters (response rate = 90%; 69% female, 54% Hispanic, 85% born outside of the U.S.).

Results

Phase 1. Stressors were patient-based (seeing young patients decline), interactions with medical team (unsure of role), and systems-based (appointment unpredictability). Phase 2. At baseline interpreters reported low abilities to cope with stress (measured by the Measure of Current Status (MOCS-A)). At 4-week follow-up we found improvements in job satisfaction (p = .02; Cohen's d = .41) and declines in sick days (p = .08; Cohen's d = .38). Stress reactivity (MOCS-A) improved; specifically participants reported feeling more assertive about their needs (p = .10; Cohen's d = .30) and more able to relax at will (p = .10; Cohen's d = .35)—important mechanisms to lower distress.

Conclusions

We piloted a resiliency program for medical interpreters in cancer care. We found that interpreters experience distress and have low coping skills. This program resulted in improved work factors and stress reactivity. Future research should include further implementation and testing in a larger, randomized trial. Copyright © 2016 John Wiley & Sons, Ltd.

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Oncology and medical education—past, present and future

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Prevalence of obesity in Chambal region and predictors of risk factors

2016-05-16T04-45-42Z
Source: International Journal of Advances in Medicine
Sushma Trikha, Neelima Singh.
Background: The prevalence of obesity is alarmingly high, affecting both developed and developing countries of all socio-economic groups, irrespective of age, sex or ethnicity. As the prevalence of obesity increases so does the burden of its associated co-morbidities. The purpose of this study was to evaluate the prevalences of overweight and obesity in our region, study the association between family history of diabetes (FHD) and body mass index (BMI) and to assess the relationship between family history of obesity and body mass index (BMI). Methods: A cross sectional population based study of 1017 randomly selected individuals was conducted. Pregnant patients and those with hypothyroidism, severe disability or severe psychiatric disturbance were excluded. Study included school going children, college going students, employees of medical college GRMC Gwalior and attendants of indoor and outdoor patients. Weight and height were measured and body mass index calculated. Patients with BMI > 23 kg/m2 were defined as overweight and those with BMI 27.5 kg/m2 and above were labelled as obese as per the WHO recommendation for Asian population. Results: A total of 1017 patients were included in this study. There were 573 (56.34%) males and 444(43.66 %) females. Overall prevalence of overweight was 251(24.6%) and prevalence of obesity was (25) 2.4%. 93 (33.69%) of those with BMI >23 had family history of obesity while the figure was 81 (10.93%) in those with BMI 23 had family history of diabetes and 40 (5.39%) with BMI 23 consumed alcohol compared to 11 (7.5%) cases with BMI


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A role for loop G in the β1 strand in GABAA receptor activation

The GABA_A receptor α subunit β1 strand runs anti-parallel to the β2 strand, which contains loop D, known to participate in receptor activation and agonist binding. However, a role for the β1 strand has yet to be established. We used molecular dynamics simulation to quantify the solvent accessible surface area (SASA) of β1 strand residues in the GABA_A β3 homopentamer structure. Residues in the complementary interface equivalent to those between Asp43 and Thr47 in the a1 subunit have an alternating pattern of high and low SASA consistent with a β strand structure. We investigated the functional role of these β1 strand residues in the α1 subunit by individually replacing them with Cys residues. D43C and T47C substitutions reduced the apparent potency of GABA at α1β2γ2 receptors by around 50-fold and 8-fold, respectively, whereas the F45C substitution caused a biphasic GABA concentration-response relationship and increased spontaneous gating. Receptors with D43C or T47C substitutions were sensitive to MTSEA modification. However, GABA-evoked currents mediated by α1(F45C)β2γ2 receptors were unaffected by MTSEA, suggesting that this residue is inaccessible. Both GABA and the allosteric agonist propofol reduced MTSEA modification of α1(D43C)β2γ2 and α1(T47C)β2γ2 receptors indicating movement of the β1 strand even during allosteric activation. This is in contrast to α1(F64C)β2γ2 receptors where only GABA, but not propofol reduced MTSEA modification. These findings provide the first functional evidence for movement of the β1 strand during gating of the receptor and identify residues that are critical for maintaining GABA_A receptor function.

This article is protected by copyright. All rights reserved

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OtoRhinoLaryngology & Medicine,New Articles,May 16th,2016,a

Emergency primary care personnel's perception of professional-patient interaction in aggressive incidents -- a qualitative study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

BMC Family Practice from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1XeqZWk via IFTTT

The potential role of lung ultrasound B-lines for detection of lung radio-induced toxicity in breast cancer patients after radiation therapy

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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Decreased rate of hip fracture and consequent reduction in estimated medical costs in Japan

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

Journal of Bone and Mineral Metabolism from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1XeqI5X via IFTTT

Parallel transverse uterine incisions to control postpartum hemorrhage and preserve fertility during cesarean delivery for placenta previa and accreta

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

International Journal of Gynecology & Obstetrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1qn4ktZ via IFTTT

The impact of codeine re-scheduling on misuse: A retrospective review of calls to Australia's largest poisons centre

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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Pressure ulcers, indentation marks and pain from cervical spine immobilization with extrication collars and headblocks: An observational study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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Iris reconstruction combined with iris-claw intraocular lens implantation for the management of iris-lens injured patients

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

Indian Journal of Ophthalmology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1XeqUSy via IFTTT

The role of bias by emergency department providers in care for American Indian children

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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Coping with suicidal urges among youth seen in a psychiatric emergency department

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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Comparison of patient- and practitioner-reported toxic effects associated with chemoradiotherapy for head and neck cancer

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

JAMA Otolaryngology—Head & Neck Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1qn4rFU via IFTTT

Buckling up in Singapore: residency and other risk factors for seatbelt non-compliance – a cross-sectional study based on trauma registry data

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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Subacute posttraumatic complaints and psychological distress in trauma patients with or without mild traumatic brain injury

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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Botulinum toxin therapy for neurogenic detrusor hyperactivity versus augmentation enterocystoplasty: impact on the quality of life of patients with SCI

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

Spinal Cord from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1XeqFal via IFTTT

Association between body composition and hip fractures in older women with physical frailty

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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An electronic emergency triage system to improve patient distribution by critical outcomes

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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Prevalence of strangulation in survivors of sexual assault and domestic violence

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

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Risk factors for subsequent hemorrhage in patients with cerebellar arteriovenous malformations

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα

World Neurosurgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1XeqNGE via IFTTT

Provocative stimulation of the hypothalamic–pituitary–testicular axis in men with spinal cord injury

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

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Outcomes of acute care surgical cases performed at night

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

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Does the choice of mobile C-arms lead to a reduction of the intraoperative radiation dose?

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

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Quinine-Induced Disseminated Intravascular Coagulation

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 20 δευτερόλεπτα

Every drug comes with some side effect. It is the benefit/risk ratio that determines the medical use of the drug. Quinine, a known antimalarial drug, has been used for nocturnal leg cramps since the 1930s; it is associated with severe life-threatening hematological and cardiovascular side effects. Disseminated intravascular coagulation (DIC), albeit rare, is a known coagulopathy associated with Quinine. It is imperative to inquire about the Quinine intake in medication history in patients with coagulopathy, as most patients still consider it a harmless home remedy for nocturnal leg... περισσότερα »

High viscosity to highly dispersed PtPd bimetallic nanocrystals for enhanced catalytic activity and stability

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα

[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC00912C, Communication Jie Ying, Zhi-Yi Hu, Xiao-Yu Yang, Hao Wei, Yu-Xuan Xiao, Christoph Janiak, Shichun Mu, Ge Tian, Mu Pan, Gustaaf Van Tendeloo, Bao-Lian Su A facile high-viscosity-solvent method is presented to synthesize PtPd bimetallic nanocrystals highly dispersed in different mesostructures (2D and 3D structures), porosities (large and small pore sizes), and compositions (silica and... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inore... περισσότερα »

Fluorescence enhancement through the formation of a single-layer two-dimensional supramolecular organic framework and its application in highly selective recognition of picric acid

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα

[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC03631G, Communication Xin Zhao, Ying Zhang, Tian-Guang Zhan, Tian-You Zhou, Qiao-Yan Qi, Xiao-Na Xu A two-dimensional (2D) supramolecular organic framework (SOF) has been constructed through the co-assembly of a triphenylamine-based building block and cucurbit[8]uril (CB[8]). Fluorescence turn-on of the non-emissive building block was observed... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1ZWrmEa via IFTTT

Improving the hydrogen selectivity of graphene oxide membranes by reducing non-selective pores with intergrown ZIF-8 crystals

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα

[image: GA?id=C6CC02013E] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC02013E, Communication Xuerui Wang, Chenglong Chi, Jifang Tao, Yongwu Peng, Shaoming Ying, Yuhong Qian, Jinqiao Dong, Zhigang Hu, Yuandong Gu, Dan Zhao The large defects of graphene oxide membranes were reduced by the intergrown ZIF-8 crystals, affording dramatically increased gas separation performance. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoread... περισσότερα »

Quantitative analysis of the modeled ATP hydrolysis in water by a colorimetric sensor array

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα

[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC02923J, Communication Tsuyoshi Minami, Fereshteh Emami, Ryuhei Nishiyabu, Yuji Kubo, Pavel Anzenbacher, Jr Self-assembled colorimetric sensors have been prepared from ZnII-DPA-attached phenylboronic acid (1[round bullet, filled]Zn) and catechol-type dyes. The 1[round bullet, filled]Zn-dye sensors display selectivity towards oligophosphate over monophosphates. The colorimetric sensor assay (1[round bullet, filled]Zn-dye) is utilized... The content of this RSS Feed (c) The Royal Society of Chemistry ...περισσότερα »

Sandwich phosphate complexes of macrocyclic tris(urea) ligands and their rotation around the anion

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα

[image: GA?id=C6CC03144G] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC03144G, Communication Liguo Ji, Zaiwen Yang, Yanxia Zhao, Meng Sun, Liping Cao, Xiao-Juan Yang, Yao-Yu Wang, Biao Wu Sandwich-type phosphate complexes were formed by macrocyclic ligands incorporating both anion- (tris-urea unit) and cation-binding sites (polyether), which display a reversible rotation around the anion upon protonation/deprotonation of phosphate and binding of the cation (Emim+). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of ... περισσότερα »

Small Molecule Recognition of Mephedrone using an Anthracene Molecular Clip

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 25 δευτερόλεπτα

[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC03404G, Communication kathryn kellett, Johnathan H Broome, Mire Zloh, Stewart B. Kirton, Suzanne Fergus, Ute Gerhard, Jacqueline Leslie Stair, Karl Wallace An anthracene molecular probe has been synthesised and shown to target mephedrone, a stimulant drug from the cathinone class of new psychoactive substances (NPS). A protocol has been developed to... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1ZWrhQU via IFTTT

miR-155 as a Biomarker in B-Cell Malignancies

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 25 δευτερόλεπτα

MicroRNAs have the potential to be useful biomarkers in the development of individualized treatment since they are easy to detect, are relatively stable during sample handling, and are important determinants of cellular processes controlling pathogenesis, progression, and response to treatment of several types of cancers including B-cell malignancies. miR-155 is an oncomiR with a crucial role in tumor initiation and development of several B-cell malignancies. The present review elucidates the potential of miR-155 as a diagnostic, prognostic, or predictive biomarker in B-cell malign... περισσότερα »

IJMS, Vol. 17, Pages 736: Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from 177Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

[image: ag] Radiolabeled antibodies (mAbs) provide efficient tools for cancer therapy. The combination of low energy β−-emissions (500 keVmax; 130 keVave) along with a γ-emission for imaging makes 177Lu (T1/2 = 6.7 day) a suitable radionuclide for radioimmunotherapy (RIT) of tumor burdens possibly too large to treat with α-particle radiation. RIT with 177Lu-trastuzumab has proven to be effective for treatment of disseminated HER2 positive peritoneal disease in a pre-clinical model. To elucidate mechanisms originating from this RIT therapy at the molecular level, tumor bearing mice...περισσότερα »

IJMS, Vol. 17, Pages 731: Key Developments in Ionic Liquid Crystals

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

[image: ag] Ionic liquid crystals are materials that combine the classes of liquid crystals and ionic liquids. The first one is based on the multi-billion-dollar flat panel display industry, whilst the latter quickly developed in the past decades into a family of highly-tunable non-volatile solvents. The combination yields materials with a unique set of properties, but also with many challenges ahead. In this review, we provide an overview of the key concepts in ionic liquid crystals, particularly from a molecular perspective. What are the important molecular parameters that determ... περισσότερα »

Laws, Vol. 5, Pages 23: Are Cutbacks to Personal Assistance Violating Sweden's Obligations under the UN Convention on the Rights of Persons with Disabilities?

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

Article 19 of the UN Convention on the Rights of Persons with Disabilities requires states to ensure that disabled people can choose where and with whom they live with access to a range of services including personal assistance. Based on qualitative research of the implementation of Article 19 in Nordic countries, this paper focuses on Sweden, which was at the forefront of implementing personal assistance law and policy and has been the inspiration for many European countries. Instead of strengthening access to personal assistance, this study found that since the Swedish governmen... περισσότερα »

IJMS, Vol. 17, Pages 736: Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from 177Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

[image: ag] Radiolabeled antibodies (mAbs) provide efficient tools for cancer therapy. The combination of low energy β−-emissions (500 keVmax; 130 keVave) along with a γ-emission for imaging makes 177Lu (T1/2 = 6.7 day) a suitable radionuclide for radioimmunotherapy (RIT) of tumor burdens possibly too large to treat with α-particle radiation. RIT with 177Lu-trastuzumab has proven to be effective for treatment of disseminated HER2 positive peritoneal disease in a pre-clinical model. To elucidate mechanisms originating from this RIT therapy at the molecular level, tumor bearing mice...περισσότερα »

IJMS, Vol. 17, Pages 742: Recent Progress in Treating Protein–Ligand Interactions with Quantum-Mechanical Methods

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

We review the first successes and failures of a "new wave" of quantum chemistry-based approaches to the treatment of protein/ligand interactions. These approaches share the use of "enhanced", dispersion (D), and/or hydrogen-bond (H) corrected density functional theory (DFT) or semi-empirical quantum mechanical (SQM) methods, in combination with ensemble weighting techniques of some form to capture entropic effects. Benchmark and model system calculations in comparison to high-level theoretical as well as experimental references have shown that both DFT-D (dispersion-corrected dens... περισσότερα »

Nutrients, Vol. 8, Pages 297: Persistent Inequalities in Child Undernutrition in Cambodia from 2000 until Today

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

The study assessed the trends of nutritional status of children under age five in Cambodia over four DHS surveys from 2000 to 2014 and the contribution of socioeconomic and demographic factors to its changes. Undernutrition was a public health problem in all surveys. Despite consistent improvement over the years, stunting still affected 32.5% of children in 2014. Wasting prevalence did not improve since 2005 and affected 9.6% of children under five in 2014. Low wealth and mother education; and rural residence contributed to undernutrition. In 2014; wealth status was the main socio... περισσότερα »

Applied Sciences, Vol. 6, Pages 150: State of the Art of Tactile Micro Coordinate Metrology

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

[image: ag] Micro parts are increasingly found in a number of industrial products. They often have complex geometrical features in the millimeter to micrometer range which are not accessible or difficult to measure by conventional coordinate measuring machines or by optical microscopy techniques. In the last years, several concepts of tactile micro coordinate measuring machines have been developed in research laboratories and were partly commercialized by industry. The major challenges were related to the development of innovative micro probes, to the requirements for traceability ... περισσότερα »

Sustainability, Vol. 8, Pages 482: ELV Recycling Service Provider Selection Using the Hybrid MCDM Method: A Case Application in China

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

With the rapid depletion of natural resources and undesired environmental changes globally, more interest has been shown in the research of green supply chain practices, including end-of-life vehicle (ELV) recycling. The ELV recycling is mandatory for auto-manufacturers by legislation for the purpose of minimizing potential environmental damages. The purpose of the present research is to determine the best choice of ELV recycling service provider by employing an integrating hybrid multi-criteria decision making (MCDM) method. In this research, economic, environmental and social fac... περισσότερα »

Sensors, Vol. 16, Pages 705: Xurography as a Rapid Fabrication Alternative for Point-of-Care Devices: Assessment of Passive Micromixers

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

Despite the copious amount of research on the design and operation of micromixers, there are few works regarding manufacture technology aimed at implementation beyond academic environments. This work evaluates the viability of xurography as a rapid fabrication tool for the development of ultra-low cost microfluidic technology for extreme Point-of-Care (POC) micromixing devices. By eschewing photolithographic processes and the bulkiness of pumping and enclosure systems for rapid fabrication and passively driven operation, xurography is introduced as a manufacturing alternative for ...περισσότερα »

Sensors, Vol. 16, Pages 704: Kinect-Based Virtual Game for the Elderly that Detects Incorrect Body Postures in Real Time

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

Poor posture can result in loss of physical function, which is necessary to preserving independence in later life. Its decline is often the determining factor for loss of independence in the elderly. To avoid this, a system to correct poor posture in the elderly, designed for Kinect-based indoor applications, is proposed in this paper. Due to the importance of maintaining a healthy life style in senior citizens, the system has been integrated into a game which focuses on their physical stimulation. The game encourages users to perform physical activities while the posture correcti... περισσότερα »

IJMS, Vol. 17, Pages 731: Key Developments in Ionic Liquid Crystals

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 33 δευτερόλεπτα

[image: ag] Ionic liquid crystals are materials that combine the classes of liquid crystals and ionic liquids. The first one is based on the multi-billion-dollar flat panel display industry, whilst the latter quickly developed in the past decades into a family of highly-tunable non-volatile solvents. The combination yields materials with a unique set of properties, but also with many challenges ahead. In this review, we provide an overview of the key concepts in ionic liquid crystals, particularly from a molecular perspective. What are the important molecular parameters that determ... περισσότερα »

Laws, Vol. 5, Pages 23: Are Cutbacks to Personal Assistance Violating Sweden's Obligations under the UN Convention on the Rights of Persons with Disabilities?

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 33 δευτερόλεπτα

Article 19 of the UN Convention on the Rights of Persons with Disabilities requires states to ensure that disabled people can choose where and with whom they live with access to a range of services including personal assistance. Based on qualitative research of the implementation of Article 19 in Nordic countries, this paper focuses on Sweden, which was at the forefront of implementing personal assistance law and policy and has been the inspiration for many European countries. Instead of strengthening access to personal assistance, this study found that since the Swedish governmen... περισσότερα »

IJMS, Vol. 17, Pages 736: Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from 177Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 33 δευτερόλεπτα

[image: ag] Radiolabeled antibodies (mAbs) provide efficient tools for cancer therapy. The combination of low energy β−-emissions (500 keVmax; 130 keVave) along with a γ-emission for imaging makes 177Lu (T1/2 = 6.7 day) a suitable radionuclide for radioimmunotherapy (RIT) of tumor burdens possibly too large to treat with α-particle radiation. RIT with 177Lu-trastuzumab has proven to be effective for treatment of disseminated HER2 positive peritoneal disease in a pre-clinical model. To elucidate mechanisms originating from this RIT therapy at the molecular level, tumor bearing mice...περισσότερα »

IJMS, Vol. 17, Pages 742: Recent Progress in Treating Protein–Ligand Interactions with Quantum-Mechanical Methods

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 33 δευτερόλεπτα

We review the first successes and failures of a "new wave" of quantum chemistry-based approaches to the treatment of protein/ligand interactions. These approaches share the use of "enhanced", dispersion (D), and/or hydrogen-bond (H) corrected density functional theory (DFT) or semi-empirical quantum mechanical (SQM) methods, in combination with ensemble weighting techniques of some form to capture entropic effects. Benchmark and model system calculations in comparison to high-level theoretical as well as experimental references have shown that both DFT-D (dispersion-corrected dens... περισσότερα »

Nutrients, Vol. 8, Pages 297: Persistent Inequalities in Child Undernutrition in Cambodia from 2000 until Today

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 33 δευτερόλεπτα

The study assessed the trends of nutritional status of children under age five in Cambodia over four DHS surveys from 2000 to 2014 and the contribution of socioeconomic and demographic factors to its changes. Undernutrition was a public health problem in all surveys. Despite consistent improvement over the years, stunting still affected 32.5% of children in 2014. Wasting prevalence did not improve since 2005 and affected 9.6% of children under five in 2014. Low wealth and mother education; and rural residence contributed to undernutrition. In 2014; wealth status was the main socio... περισσότερα »

Applied Sciences, Vol. 6, Pages 150: State of the Art of Tactile Micro Coordinate Metrology

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 33 δευτερόλεπτα

[image: ag] Micro parts are increasingly found in a number of industrial products. They often have complex geometrical features in the millimeter to micrometer range which are not accessible or difficult to measure by conventional coordinate measuring machines or by optical microscopy techniques. In the last years, several concepts of tactile micro coordinate measuring machines have been developed in research laboratories and were partly commercialized by industry. The major challenges were related to the development of innovative micro probes, to the requirements for traceability ... περισσότερα »

Sustainability, Vol. 8, Pages 482: ELV Recycling Service Provider Selection Using the Hybrid MCDM Method: A Case Application in China

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 33 δευτερόλεπτα

With the rapid depletion of natural resources and undesired environmental changes globally, more interest has been shown in the research of green supply chain practices, including end-of-life vehicle (ELV) recycling. The ELV recycling is mandatory for auto-manufacturers by legislation for the purpose of minimizing potential environmental damages. The purpose of the present research is to determine the best choice of ELV recycling service provider by employing an integrating hybrid multi-criteria decision making (MCDM) method. In this research, economic, environmental and social fac... περισσότερα »

Sensors, Vol. 16, Pages 705: Xurography as a Rapid Fabrication Alternative for Point-of-Care Devices: Assessment of Passive Micromixers

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 33 δευτερόλεπτα

Despite the copious amount of research on the design and operation of micromixers, there are few works regarding manufacture technology aimed at implementation beyond academic environments. This work evaluates the viability of xurography as a rapid fabrication tool for the development of ultra-low cost microfluidic technology for extreme Point-of-Care (POC) micromixing devices. By eschewing photolithographic processes and the bulkiness of pumping and enclosure systems for rapid fabrication and passively driven operation, xurography is introduced as a manufacturing alternative for ...περισσότερα »

Arenediazonium salts as electrophiles for the oxidative addition of gold(I)

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 40 δευτερόλεπτα

[image: GA?id=C6CC03105F] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC03105F, Communication Eric Omar Asomoza-Solis, Jonathan Rojas-Ocampo, Ruben Alfredo Toscano, Susana Porcel Arenediazonium salts have been found to behave as efficient electrophiles for the oxidation of gold(I). Starting from anilines, a one pot cross-coupling reaction of anilines with silver acetylides mediated by gold has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from Bi...περισσότερα »

Coping with stress: Workplace tips

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1sgRDlJ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Humidifiers: Air moisture eases skin, breathing symptoms

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1sgRAGx via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Toxins, Vol. 8, Pages 145: Degradation of Swainsonine by the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp. HW08

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα

Swainsonine is an indolizidine alkaloid that has been found in locoweeds and some fungi. Our previous study demonstrated that Arthrobacter sp. HW08 or its crude enzyme extract could degrade swainsonie efficiently. However, the mechanism of swainsonine degradation in bacteria remains unclear. In this study, we used label-free quantitative proteomics method based on liquid chromatography-electrospray ionization-tandem […]

CME: Was Sie über moderne Schwangerenvorsorge wissen müssen

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα

Mutterschafts-Richtlinien Geburtshilfe beruht auf dem Konzept der Schwangerenvorsorge. Frauenärztinnen und -ärzte müssen ihr Vorgehen immer wieder überprüfen und an aktuelle Gegebenheiten und Vorgaben anpassen. Ein Überblick zum jetzigen Stand. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Th4D5m via IFTTT

Entropy, Vol. 18, Pages 184: Selection of Entropy Based Features for Automatic Analysis of Essential Tremor

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Biomedical systems produce biosignals that arise from interaction mechanisms. In a general form, those mechanisms occur across multiple scales, both spatial and temporal, and contain linear and non-linear information. In this framework, entropy measures are good candidates in order provide useful evidence about disorder in the system, lack of information in time-series and/or irregularity of the signals. The most common movement disorder is essential tremor (ET), which occurs 20 times more than Parkinson's disease. Interestingly, about 50%–70% of the cases of ET have a genetic ori...περισσότερα »

Remote Sensing, Vol. 8, Pages 417: Retrieval of Aerosol Fine-Mode Fraction from Intensity and Polarization Measurements by PARASOL over East Asia

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

[image: ag] The fine-mode fraction (FMF) of aerosol optical depth (AOD) is a key optical parameter that represents the proportion of fine particles relative to total aerosols in the atmosphere. However, in comparison to ground-based measurements, the FMF is still difficult to retrieve from satellite observations, as attempted by a Moderate-resolution Imaging Spectroradiometer (MODIS) algorithm. In this paper, we introduce the retrieval of FMF based on Polarization and Anisotropy of Reflectances for Atmospheric Science coupled with Observations from a Lidar (PARASOL) data. This met...περισσότερα »

Societies, Vol. 6, Pages 18: The Portrayal of Occupational Therapy and Occupational Science in Canadian Newspapers: A Content Analysis

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

The primary goal of occupational therapy is to enable people to participate in the activities of everyday life. The demand for occupational therapists in Canada is expected to grow sharply at an annual growth rate of 3.2%, compared to 0.7% for all occupations. At the same time, it is believed by occupational therapists in Canada that the Canadian public does not understand the role of occupational therapy. Occupational science is an emerging basic science field that supports the practice of occupational therapy. Given that newspapers are one source the public uses to obtain inform... περισσότερα »

Nutrients, Vol. 8, Pages 298: Adequate Iodine Status in New Zealand School Children Post-Fortification of Bread with Iodised Salt

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Iodine deficiency re-emerged in New Zealand in the 1990s, prompting the mandatory fortification of bread with iodised salt from 2009. This study aimed to determine the iodine status of New Zealand children when the fortification of bread was well established. A cross-sectional survey of children aged 8–10 years was conducted in the cities of Auckland and Christchurch, New Zealand, from March to May 2015. Children provided a spot urine sample for the determination of urinary iodine concentration (UIC), a fingerpick blood sample for Thyroglobulin (Tg) concentration, and completed a ... περισσότερα »

miR-155 as a Biomarker in B-Cell Malignancies

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

MicroRNAs have the potential to be useful biomarkers in the development of individualized treatment since they are easy to detect, are relatively stable during sample handling, and are important determinants of cellular processes controlling pathogenesis, progression, and response to treatment of several types of cancers including B-cell malignancies. miR-155 is an oncomiR with a crucial role in tumor initiation and development of several B-cell malignancies. The present review elucidates the potential of miR-155 as a diagnostic, prognostic, or predictive biomarker in B-cell malign... περισσότερα »

Long-term Follow-up Data from Pivotal Studies of Adjuvant Trastuzumab in Early Breast Cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 45 δευτερόλεπτα

Abstract The addition of adjuvant trastuzumab therapy for 1 year to standard chemotherapy significantly improved disease-free survival and overall survival versus chemotherapy alone in a number of pivotal early breast cancer studies. Here we review long-term follow-up data on the efficacy, cardiac safety, and general safety of trastuzumab in these pivotal studies. We also evaluate ongoing phase II/III adjuvant trials with newer HER2-targeted agents and the efficacy and safety of the recently developed subcutaneous (SC) formulation of trastuzumab in early breast cancer. Long-term f... περισσότερα »

Sensors, Vol. 16, Pages 704: Kinect-Based Virtual Game for the Elderly that Detects Incorrect Body Postures in Real Time

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα

Poor posture can result in loss of physical function, which is necessary to preserving independence in later life. Its decline is often the determining factor for loss of independence in the elderly. To avoid this, a system to correct poor posture in the elderly, designed for Kinect-based indoor applications, is proposed in this paper. Due to the importance of maintaining a healthy life style in senior citizens, the system has been integrated into a game which focuses on their physical stimulation. The game encourages users to perform physical activities while the posture correcti... περισσότερα »

Entropy, Vol. 18, Pages 184: Selection of Entropy Based Features for Automatic Analysis of Essential Tremor

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα

Biomedical systems produce biosignals that arise from interaction mechanisms. In a general form, those mechanisms occur across multiple scales, both spatial and temporal, and contain linear and non-linear information. In this framework, entropy measures are good candidates in order provide useful evidence about disorder in the system, lack of information in time-series and/or irregularity of the signals. The most common movement disorder is essential tremor (ET), which occurs 20 times more than Parkinson's disease. Interestingly, about 50%–70% of the cases of ET have a genetic ori...περισσότερα »

Remote Sensing, Vol. 8, Pages 417: Retrieval of Aerosol Fine-Mode Fraction from Intensity and Polarization Measurements by PARASOL over East Asia

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα

[image: ag] The fine-mode fraction (FMF) of aerosol optical depth (AOD) is a key optical parameter that represents the proportion of fine particles relative to total aerosols in the atmosphere. However, in comparison to ground-based measurements, the FMF is still difficult to retrieve from satellite observations, as attempted by a Moderate-resolution Imaging Spectroradiometer (MODIS) algorithm. In this paper, we introduce the retrieval of FMF based on Polarization and Anisotropy of Reflectances for Atmospheric Science coupled with Observations from a Lidar (PARASOL) data. This met...περισσότερα »

Societies, Vol. 6, Pages 18: The Portrayal of Occupational Therapy and Occupational Science in Canadian Newspapers: A Content Analysis

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα

The primary goal of occupational therapy is to enable people to participate in the activities of everyday life. The demand for occupational therapists in Canada is expected to grow sharply at an annual growth rate of 3.2%, compared to 0.7% for all occupations. At the same time, it is believed by occupational therapists in Canada that the Canadian public does not understand the role of occupational therapy. Occupational science is an emerging basic science field that supports the practice of occupational therapy. Given that newspapers are one source the public uses to obtain inform... περισσότερα »

Nutrients, Vol. 8, Pages 298: Adequate Iodine Status in New Zealand School Children Post-Fortification of Bread with Iodised Salt

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα

Iodine deficiency re-emerged in New Zealand in the 1990s, prompting the mandatory fortification of bread with iodised salt from 2009. This study aimed to determine the iodine status of New Zealand children when the fortification of bread was well established. A cross-sectional survey of children aged 8–10 years was conducted in the cities of Auckland and Christchurch, New Zealand, from March to May 2015. Children provided a spot urine sample for the determination of urinary iodine concentration (UIC), a fingerpick blood sample for Thyroglobulin (Tg) concentration, and completed a ... περισσότερα »

miR-155 as a Biomarker in B-Cell Malignancies

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα

MicroRNAs have the potential to be useful biomarkers in the development of individualized treatment since they are easy to detect, are relatively stable during sample handling, and are important determinants of cellular processes controlling pathogenesis, progression, and response to treatment of several types of cancers including B-cell malignancies. miR-155 is an oncomiR with a crucial role in tumor initiation and development of several B-cell malignancies. The present review elucidates the potential of miR-155 as a diagnostic, prognostic, or predictive biomarker in B-cell malign... περισσότερα »

Energies, Vol. 9, Pages 372: Black Start Strategy for PV-ESS Multi-Microgrids with Three-Phase/Single-Phase Architecture

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

With the rapid development of microgrids (MGs) in recent years, it is anticipated that combinations of multiple microgrids—multi-microgrids (MMGs)—will gradually become a new form of power grid. A safe and efficient black start strategy for MMGs is in urgent demand because of their complicated structure and control systems. In this paper, first, we analyze the… Continue reading Energies, Vol. 9, Pages 372: Black Start Strategy for PV-ESS Multi-Microgrids with Three-Phase/Single-Phase Architecture

Energies, Vol. 9, Pages 368: Assessment of the Variability of Biogas Production from Sugar Beet Silage as Affected by Movement and Loss of the Produced Alcohols and Organic Acids

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

The biochemical methane potential and composition of sugar beet pulp silage were investigated using samples taken from six different depths in both open and closed silos (height 3.6 m). The biochemical methane potential (BMP) of pulp silage in open silos ranged from 337 to 420 normal litre (NL) CH4/kg volatile solids (VS), while the BMP… Continue reading Energies, Vol. 9, Pages 368: Assessment of the Variability of Biogas Production from Sugar Beet Silage as Affected by Movement and Loss of the Produced Alcohols and Organic Acids

IJMS, Vol. 17, Pages 736: Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from 177Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Radiolabeled antibodies (mAbs) provide efficient tools for cancer therapy. The combination of low energy β−-emissions (500 keVmax; 130 keVave) along with a γ-emission for imaging makes 177Lu (T1/2 = 6.7 day) a suitable radionuclide for radioimmunotherapy (RIT) of tumor burdens possibly too large to treat with α-particle radiation. RIT with 177Lu-trastuzumab has proven to be… Continue reading IJMS, Vol. 17, Pages 736: Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from 177Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tum... περισσότερα »

IJERPH, Vol. 13, Pages 502: Prevalence and Factors Associated with Substance Use and Misuse among Kosovar Adolescents; Cross Sectional Study of Scholastic, Familial-, and Sports-Related Factors of Influence

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Adolescence is considered to be the most important period for the prevention of substance use and misuse (SUM). The aim of this study was to investigate the problem of SUM and to establish potentially important factors associated with SUM in Kosovar adolescents. Multi-stage simple random sampling was used to select participants. At the end of… Continue reading IJERPH, Vol. 13, Pages 502: Prevalence and Factors Associated with Substance Use and Misuse among Kosovar Adolescents; Cross Sectional Study of Scholastic, Familial-, and Sports-Related Factors of Influence

IJMS, Vol. 17, Pages 742: Recent Progress in Treating Protein–Ligand Interactions with Quantum-Mechanical Methods

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

We review the first successes and failures of a "new wave" of quantum chemistry-based approaches to the treatment of protein/ligand interactions. These approaches share the use of "enhanced", dispersion (D), and/or hydrogen-bond (H) corrected density functional theory (DFT) or semi-empirical quantum mechanical (SQM) methods, in combination with ensemble weighting techniques of some form to capture… Continue reading IJMS, Vol. 17, Pages 742: Recent Progress in Treating Protein–Ligand Interactions with Quantum-Mechanical Methods

Applied Sciences, Vol. 6, Pages 152: Superhydrophobic Surfaces Created by Elastic Instability of PDMS

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Lotus flowers, rose petals, some plant leaves and insects have a naturally super-hydrophobic surface. In fact, the surface of a Lotus leaf is covered by micro and nano structures mixed with wax, which makes its surface superhydrophobic. In microfluidics, superhydrophobicity is an important factor in the rheometers on a chip. It is also sought in… Continue reading Applied Sciences, Vol. 6, Pages 152: Superhydrophobic Surfaces Created by Elastic Instability of PDMS

Nobel laureate Tomas Lindahl explains the science behind his life's work for #ecancertv: https://t.co/PUytxGRvo2 https://t.co/ZLctz41A0j

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Nobel laureate Tomas Lindahl explains the science behind his life's work for #ecancertv: https://t.co/PUytxGRvo2 https://t.co/ZLctz41A0j from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/732129765411434496 via IFTTT

Sensors, Vol. 16, Pages 703: Anchoring of FRET Sensors—A Requirement for Spatiotemporal Resolution

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

FRET biosensors have become a routine tool for investigating mechanisms and components of cell signaling. Strategies for improving them for particular applications are continuously sought. One important aspect to consider when designing FRET probes is the dynamic distribution and propagation of signals within living cells. We have addressed this issue by directly comparing an anchored… Continue reading Sensors, Vol. 16, Pages 703: Anchoring of FRET Sensors—A Requirement for Spatiotemporal Resolution

New biomarker identifies colorectal cancer paitents likely to benefit most from cetuximab: https://t.co/udxVWP4pYE

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

New biomarker identifies colorectal cancer paitents likely to benefit most from cetuximab: https://t.co/udxVWP4pYE from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/732122434959212544 via IFTTT

Gene therapy against brain cancer: https://t.co/YzSpi3SObQ

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Gene therapy against brain cancer: https://t.co/YzSpi3SObQ from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/732118261882605568 via IFTTT

Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

Journal of Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1XebcqO Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Full title: a meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

Pancreatology from #Medicine via ola Kala on Inoreader http://ift.tt/23UxpKy Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Multiple hepatitis B virus (HBV) quasispecies and immune-escape mutations are present in HBV surface antigen and reverse transcriptase of patients with acute hepatitis B

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

The Journal of Infectious Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1XebnlS Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Biologic therapies and risk of infection and malignancy in patients with inflammatory bowel disease: A systematic review and network meta-analysis

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

Clinical Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1XeaN7K Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

International Journal of Cancer from #Medicine via ola Kala on Inoreader http://ift.tt/1XeaPfP Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Plasma renin concentration represents an independent risk factor for mortality and is associated with liver dysfunction in patients with cirrhosis

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

Journal of Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW8g1c Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Invasive Fusobacterium nucleatum may play a role in the carcinogenesis of proximal colon cancer through the serrated neoplasia pathway

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

International Journal of Cancer from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW8buf Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Prevalence of QT interval prolongation in inflammatory bowel disease

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

The Turkish Journal of Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW83Lq Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Long-term Follow-up Data from Pivotal Studies of Adjuvant Trastuzumab in Early Breast Cancer

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Abstract The addition of adjuvant trastuzumab therapy for 1 year to standard chemotherapy significantly improved disease-free survival and overall survival versus chemotherapy alone in a number of pivotal early breast cancer studies. Here we review long-term follow-up data on the efficacy, cardiac safety, and general safety of trastuzumab in these pivotal studies. We also evaluate […]

«Analysis of Clostridium difficile infections in patients hospitalized at the nephrological ward in Poland»

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Background: Few studies have evaluated the incidence and risk factors of Clostridium difficile infection (CDI) in the adult Polish population, in particular in solid organ recipients hospitalized at the nephrological ward. Aim: The aim of this study was to analyze Clostridium difficile infections (CDI) among patients hospitalized in the Department of Nephrology, Transplantation and Internal […]

«Carbamylation of proteins – mechanism, causes and consequences»

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Carbamylation (carbamoylation) is a post-translational modification resulting from the nonenzymatic reaction between isocyanic acid and free functional groups of proteins, in particular with the free amino groups. This reaction alters structural and functional properties of proteins and results in faster aging of proteins. Urea present in the body can be transformed into cyanate and its […]

Toxins, Vol. 8, Pages 145: Degradation of Swainsonine by the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp. HW08

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Swainsonine is an indolizidine alkaloid that has been found in locoweeds and some fungi. Our previous study demonstrated that Arthrobacter sp. HW08 or its crude enzyme extract could degrade swainsonie efficiently. However, the mechanism of swainsonine degradation in bacteria remains unclear. In this study, we used label-free quantitative proteomics method based on liquid chromatography-electrospray ionization-tandem […]

CME: Was Sie über moderne Schwangerenvorsorge wissen müssen

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Mutterschafts-Richtlinien Geburtshilfe beruht auf dem Konzept der Schwangerenvorsorge. Frauenärztinnen und -ärzte müssen ihr Vorgehen immer wieder überprüfen und an aktuelle Gegebenheiten und Vorgaben anpassen. Ein Überblick zum jetzigen Stand. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Th4D5m via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Predictors of renal histopathology in antineutrophil cytoplasmic antibody associated glomerulonephritis

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Publication date: Available online 15 May 2016 Source:Journal of Autoimmunity Author(s): Sophia Lionaki, Clio P. Mavragani, Alexandre Karras, George Liapis, George Somarakis, John N. Boletis, Alexandros Drosos, Athanasios G. Tzioufas, Loic Guillevin, Haralampos M. Moutsopoulos ObjectivesPrompt, aggressive therapy is vital for anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. In this regard, we aimed to identify predictors of […]

Predictors of renal histopathology in antineutrophil cytoplasmic antibody associated glomerulonephritis

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Publication date: Available online 15 May 2016 Source:Journal of Autoimmunity Author(s): Sophia Lionaki, Clio P. Mavragani, Alexandre Karras, George Liapis, George Somarakis, John N. Boletis, Alexandros Drosos, Athanasios G. Tzioufas, Loic Guillevin, Haralampos M. Moutsopoulos ObjectivesPrompt, aggressive therapy is vital for anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. In this regard, we aimed to identify predictors of […]

Viruses, Vol. 8, Pages 136: The Effect of MicroRNA bantam on Baculovirus AcMNPV Infection in Vitro and in Vivo

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

The role of microRNA bantam, one of the most abundant microRNAs in Sf9 cells, was studied for its role in baculovirus infection in vitro and in vivo. The expression level of bantam was increased after AcMNPV infection in Sf9 cells and in Spodoptera litura larvae. In Sf9 cells, application of bantam inhibitor or mimic altered […]

IJGI, Vol. 5, Pages 69: Assessment on the Impact of Arable Land Protection Policies in a Rapidly Developing Region

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

To investigate the effect of arable land protection policies in China, a practical framework that integrates geographic information systems (GIS), soil quality assessment and landscape metrics analysis was employed to track and analyze arable land transformations and landscape changes in response to rampant urbanization within the Ningbo region (China) from 2005 to 2013. The results showed that arable land loss and degradation have continued, despite the development of a comprehensive legal framework for arable land protection. The implementation of arable land protection policies...περισσότερα »

Water, Vol. 8, Pages 204: Stakeholder Engagement for Inclusive Water Governance: "Practicing What We Preach" with the OECD Water Governance Initiative

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

A cursory glance at the literature on water governance reveals that stakeholder engagement has long been considered an integral part of sound governance processes. However, a closer look at the literature reveals that, beyond this general assertion, there is a lack of evidence-based assessment on how engagement processes contribute to water governance objectives. This article addresses this research gap by presenting key findings and policy guidance from a study by the Organisation for Economic Co-operation and Development (OECD) on "Stakeholder Engagement for Inclusive Water Gove...περισσότερα »

Systems, Vol. 4, Pages 21: A Knowledge Comparison Environment for Supporting Meaningful Learning of E-Book Users

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

In this paper, we present an ontology-based visualization support system which can provide a meaningful learning environment to help e-book learners to effectively construct their knowledge frameworks. In this personalized visualization support system, learners are encouraged to actively locate new knowledge in their own knowledge framework and check the logical consistency of their ideas for clearing up misunderstandings; on the other hand, instructors will be able to decide the group distribution for collaborative learning activities based on the knowledge structure of learners.... περισσότερα »

JLPEA, Vol. 6, Pages 7: A 36 nW, 7 ppm/°C on-Chip Clock Source Platform for Near-Human-Body Temperature Applications

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

We propose a fully on-chip clock-source system in which an ultra-low-power diode-based temperature-uncompensated oscillator (OSCdiode) serves as the main clock source and frequency locks to a higher-power temperature-compensated oscillator (OSCcmp) that is disabled after each locking event to save power. The locking allows the stability of the uncompensated oscillator to stay within the stability bound of the compensated design. This paper demonstrates the functionality of a locking controller that uses a periodic (counter-based) scheme implemented on-chip and a prediction (temper... περισσότερα »

Entropy, Vol. 18, Pages 186: Quantum Thermodynamics in Strong Coupling: Heat Transport and Refrigeration

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

[image: ag] The performance characteristics of a heat rectifier and a heat pump are studied in a non-Markovian framework. The device is constructed from a molecule connected to a hot and cold reservoir. The heat baths are modelled using the stochastic surrogate Hamiltonian method. The molecule is modelled by an asymmetric double-well potential. Each well is semi-locally connected to a heat bath composed of spins. The dynamics are driven by a combined system–bath Hamiltonian. The temperature of the baths is regulated by a secondary spin bath composed of identical spins in thermal eq... περισσότερα »

Energies, Vol. 9, Pages 374: Chemical Analysis of Different Parts of Date Palm (Phoenix dactylifera L.) Using Ultimate, Proximate and Thermo-Gravimetric Techniques for Energy Production

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

The objective of the study was to analyze chemical structure of date palm (Phoenix dactylifera L.) by employing ultimate, proximate and thermo-gravimetric techniques. Samples from different anatomical parts of date palm, namely trunk, frond base, frond midrib, leaflets, coir, fruit stem, date stone, and fruit empty bunches were considered for the experiments. Based on the findings in this work palm leaflet samples gave the highest amount of extractives content (32.9%), followed by date palm stone specimens with 31.5%. Cellulose content values of 32.8% and 47.5% were obtained for d... περισσότερα »

Energies, Vol. 9, Pages 372: Black Start Strategy for PV-ESS Multi-Microgrids with Three-Phase/Single-Phase Architecture

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

[image: ag] With the rapid development of microgrids (MGs) in recent years, it is anticipated that combinations of multiple microgrids—multi-microgrids (MMGs)—will gradually become a new form of power grid. A safe and efficient black start strategy for MMGs is in urgent demand because of their complicated structure and control systems. In this paper, first, we analyze the topology and control system of residential-type MMGs with three-phase/single-phase (TP/SP) architecture. Second, a black start strategy based on a hierarchical control scheme is presented, including the selection... περισσότερα »

Energies, Vol. 9, Pages 368: Assessment of the Variability of Biogas Production from Sugar Beet Silage as Affected by Movement and Loss of the Produced Alcohols and Organic Acids

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

The biochemical methane potential and composition of sugar beet pulp silage were investigated using samples taken from six different depths in both open and closed silos (height 3.6 m). The biochemical methane potential (BMP) of pulp silage in open silos ranged from 337 to 420 normal litre (NL) CH4/kg volatile solids (VS), while the BMP of pulp silage in closed silos varied between 411 and 451 NL CH4/kg VS. The biochemical methane potential peaked at a depth of 1.45 m with 420 NL CH4/kg VS for open silos and 451 NL CH4/kg VS for closed silos. The ethanol concentration and biochemic... περισσότερα »

IJERPH, Vol. 13, Pages 502: Prevalence and Factors Associated with Substance Use and Misuse among Kosovar Adolescents; Cross Sectional Study of Scholastic, Familial-, and Sports-Related Factors of Influence

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Adolescence is considered to be the most important period for the prevention of substance use and misuse (SUM). The aim of this study was to investigate the problem of SUM and to establish potentially important factors associated with SUM in Kosovar adolescents. Multi-stage simple random sampling was used to select participants. At the end of their high school education, 980 adolescents (623 females) ages 17 to 19 years old were enrolled in the study. The prevalence of smoking, alcohol consumption (measured by Alcohol Use Disorder Identification Test–AUDIT), and illegal drug use (... περισσότερα »

Applied Sciences, Vol. 6, Pages 152: Superhydrophobic Surfaces Created by Elastic Instability of PDMS

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

[image: ag] Lotus flowers, rose petals, some plant leaves and insects have a naturally super-hydrophobic surface. In fact, the surface of a Lotus leaf is covered by micro and nano structures mixed with wax, which makes its surface superhydrophobic. In microfluidics, superhydrophobicity is an important factor in the rheometers on a chip. It is also sought in other complex fluids applications like the self-cleaning and the antibacterial materials. The wettability of the surface of solid support can be modified by altering its chemical composition. This means functionalizing the inter... περισσότερα »

Sensors, Vol. 16, Pages 703: Anchoring of FRET Sensors—A Requirement for Spatiotemporal Resolution

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

FRET biosensors have become a routine tool for investigating mechanisms and components of cell signaling. Strategies for improving them for particular applications are continuously sought. One important aspect to consider when designing FRET probes is the dynamic distribution and propagation of signals within living cells. We have addressed this issue by directly comparing an anchored (taFS) to a non-anchored (naFS) cleavable FRET sensor. We chose a microtubule-associated protein tau as an anchor, as microtubules are abundant throughout the cytosol of cells. We show that tau-ancho...περισσότερα »

Hepatitis C virus genotype 4 replication in the hepatocellular carcinoma cell line HepG2/C3A

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Saudi Journal of Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1Xebrls via IFTTT

FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

The Lancet Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1Xebqy4 via IFTTT

The Hippo pathway in intestinal regeneration and disease

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Nature Reviews Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1XebvBO via IFTTT

Parallel declines in HIV and hepatitis C virus prevalence, but not in herpes simplex virus type 2 infection: A 10-year, serial cross-sectional study in an inner-city emergency department

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Journal of Clinical Virology from #Medicine via ola Kala on Inoreader http://ift.tt/1XebgXt via IFTTT

Factors predicting adverse events associated with therapeutic colonoscopy for colorectal neoplasia: a retrospective nationwide study in Japan

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Gastrointestinal Endoscopy from #Medicine via ola Kala on Inoreader http://ift.tt/1Xeb4Hy via IFTTT

Effect of fibre supplementation on chronic idiopathic constipation in adults

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Alimentary Pharmacology and Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW8aGS via IFTTT

Immunologic and metabolic features of pancreatic ductal adenocarcinoma define prognostic subtypes of disease

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Clinical Cancer Research from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW7TDR via IFTTT

Effectiveness of add-on therapy with domperidone vs alginic acid in proton pump inhibitor partial response gastro-oesophageal reflux disease in systemic sclerosis: Randomized placebo-controlled trial

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Rheumatology from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW8160 via IFTTT

Allele-specific transcriptional activity of the variable number of tandem repeats of the inducible nitric oxide synthase gene is associated with idiopathic achalasia

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

United European Gastroenterology Journal from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW80Px via IFTTT

IJGI, Vol. 5, Pages 69: Assessment on the Impact of Arable Land Protection Policies in a Rapidly Developing Region

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

To investigate the effect of arable land protection policies in China, a practical framework that integrates geographic information systems (GIS), soil quality assessment and landscape metrics analysis was employed to track and analyze arable land transformations and landscape changes in response to rampant urbanization within the Ningbo region (China) from 2005 to 2013. The results showed that arable land loss and degradation have continued, despite the development of a comprehensive legal framework for arable land protection. The implementation of arable land protection policies...περισσότερα »

Water, Vol. 8, Pages 204: Stakeholder Engagement for Inclusive Water Governance: "Practicing What We Preach" with the OECD Water Governance Initiative

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

A cursory glance at the literature on water governance reveals that stakeholder engagement has long been considered an integral part of sound governance processes. However, a closer look at the literature reveals that, beyond this general assertion, there is a lack of evidence-based assessment on how engagement processes contribute to water governance objectives. This article addresses this research gap by presenting key findings and policy guidance from a study by the Organisation for Economic Co-operation and Development (OECD) on "Stakeholder Engagement for Inclusive Water Gove...περισσότερα »

Systems, Vol. 4, Pages 21: A Knowledge Comparison Environment for Supporting Meaningful Learning of E-Book Users

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

In this paper, we present an ontology-based visualization support system which can provide a meaningful learning environment to help e-book learners to effectively construct their knowledge frameworks. In this personalized visualization support system, learners are encouraged to actively locate new knowledge in their own knowledge framework and check the logical consistency of their ideas for clearing up misunderstandings; on the other hand, instructors will be able to decide the group distribution for collaborative learning activities based on the knowledge structure of learners.... περισσότερα »

JLPEA, Vol. 6, Pages 7: A 36 nW, 7 ppm/°C on-Chip Clock Source Platform for Near-Human-Body Temperature Applications

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

We propose a fully on-chip clock-source system in which an ultra-low-power diode-based temperature-uncompensated oscillator (OSCdiode) serves as the main clock source and frequency locks to a higher-power temperature-compensated oscillator (OSCcmp) that is disabled after each locking event to save power. The locking allows the stability of the uncompensated oscillator to stay within the stability bound of the compensated design. This paper demonstrates the functionality of a locking controller that uses a periodic (counter-based) scheme implemented on-chip and a prediction (temper... περισσότερα »

Entropy, Vol. 18, Pages 186: Quantum Thermodynamics in Strong Coupling: Heat Transport and Refrigeration

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

[image: ag] The performance characteristics of a heat rectifier and a heat pump are studied in a non-Markovian framework. The device is constructed from a molecule connected to a hot and cold reservoir. The heat baths are modelled using the stochastic surrogate Hamiltonian method. The molecule is modelled by an asymmetric double-well potential. Each well is semi-locally connected to a heat bath composed of spins. The dynamics are driven by a combined system–bath Hamiltonian. The temperature of the baths is regulated by a secondary spin bath composed of identical spins in thermal eq... περισσότερα »

Energies, Vol. 9, Pages 374: Chemical Analysis of Different Parts of Date Palm (Phoenix dactylifera L.) Using Ultimate, Proximate and Thermo-Gravimetric Techniques for Energy Production

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

The objective of the study was to analyze chemical structure of date palm (Phoenix dactylifera L.) by employing ultimate, proximate and thermo-gravimetric techniques. Samples from different anatomical parts of date palm, namely trunk, frond base, frond midrib, leaflets, coir, fruit stem, date stone, and fruit empty bunches were considered for the experiments. Based on the findings in this work palm leaflet samples gave the highest amount of extractives content (32.9%), followed by date palm stone specimens with 31.5%. Cellulose content values of 32.8% and 47.5% were obtained for d... περισσότερα »

Energies, Vol. 9, Pages 372: Black Start Strategy for PV-ESS Multi-Microgrids with Three-Phase/Single-Phase Architecture

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

[image: ag] With the rapid development of microgrids (MGs) in recent years, it is anticipated that combinations of multiple microgrids—multi-microgrids (MMGs)—will gradually become a new form of power grid. A safe and efficient black start strategy for MMGs is in urgent demand because of their complicated structure and control systems. In this paper, first, we analyze the topology and control system of residential-type MMGs with three-phase/single-phase (TP/SP) architecture. Second, a black start strategy based on a hierarchical control scheme is presented, including the selection... περισσότερα »

Energies, Vol. 9, Pages 368: Assessment of the Variability of Biogas Production from Sugar Beet Silage as Affected by Movement and Loss of the Produced Alcohols and Organic Acids

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

The biochemical methane potential and composition of sugar beet pulp silage were investigated using samples taken from six different depths in both open and closed silos (height 3.6 m). The biochemical methane potential (BMP) of pulp silage in open silos ranged from 337 to 420 normal litre (NL) CH4/kg volatile solids (VS), while the BMP of pulp silage in closed silos varied between 411 and 451 NL CH4/kg VS. The biochemical methane potential peaked at a depth of 1.45 m with 420 NL CH4/kg VS for open silos and 451 NL CH4/kg VS for closed silos. The ethanol concentration and biochemic... περισσότερα »

IJERPH, Vol. 13, Pages 502: Prevalence and Factors Associated with Substance Use and Misuse among Kosovar Adolescents; Cross Sectional Study of Scholastic, Familial-, and Sports-Related Factors of Influence

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Adolescence is considered to be the most important period for the prevention of substance use and misuse (SUM). The aim of this study was to investigate the problem of SUM and to establish potentially important factors associated with SUM in Kosovar adolescents. Multi-stage simple random sampling was used to select participants. At the end of their high school education, 980 adolescents (623 females) ages 17 to 19 years old were enrolled in the study. The prevalence of smoking, alcohol consumption (measured by Alcohol Use Disorder Identification Test–AUDIT), and illegal drug use (... περισσότερα »

Applied Sciences, Vol. 6, Pages 152: Superhydrophobic Surfaces Created by Elastic Instability of PDMS

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

[image: ag] Lotus flowers, rose petals, some plant leaves and insects have a naturally super-hydrophobic surface. In fact, the surface of a Lotus leaf is covered by micro and nano structures mixed with wax, which makes its surface superhydrophobic. In microfluidics, superhydrophobicity is an important factor in the rheometers on a chip. It is also sought in other complex fluids applications like the self-cleaning and the antibacterial materials. The wettability of the surface of solid support can be modified by altering its chemical composition. This means functionalizing the inter... περισσότερα »

Sensors, Vol. 16, Pages 703: Anchoring of FRET Sensors—A Requirement for Spatiotemporal Resolution

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

FRET biosensors have become a routine tool for investigating mechanisms and components of cell signaling. Strategies for improving them for particular applications are continuously sought. One important aspect to consider when designing FRET probes is the dynamic distribution and propagation of signals within living cells. We have addressed this issue by directly comparing an anchored (taFS) to a non-anchored (naFS) cleavable FRET sensor. We chose a microtubule-associated protein tau as an anchor, as microtubules are abundant throughout the cytosol of cells. We show that tau-ancho...περισσότερα »

Hepatitis C virus genotype 4 replication in the hepatocellular carcinoma cell line HepG2/C3A

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Saudi Journal of Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1Xebrls via IFTTT

FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

The Lancet Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1Xebqy4 via IFTTT

The Hippo pathway in intestinal regeneration and disease

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Nature Reviews Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1XebvBO via IFTTT

Parallel declines in HIV and hepatitis C virus prevalence, but not in herpes simplex virus type 2 infection: A 10-year, serial cross-sectional study in an inner-city emergency department

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Journal of Clinical Virology from #Medicine via ola Kala on Inoreader http://ift.tt/1XebgXt via IFTTT

Factors predicting adverse events associated with therapeutic colonoscopy for colorectal neoplasia: a retrospective nationwide study in Japan

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Gastrointestinal Endoscopy from #Medicine via ola Kala on Inoreader http://ift.tt/1Xeb4Hy via IFTTT

Effect of fibre supplementation on chronic idiopathic constipation in adults

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Alimentary Pharmacology and Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW8aGS via IFTTT

Immunologic and metabolic features of pancreatic ductal adenocarcinoma define prognostic subtypes of disease

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Clinical Cancer Research from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW7TDR via IFTTT

Effectiveness of add-on therapy with domperidone vs alginic acid in proton pump inhibitor partial response gastro-oesophageal reflux disease in systemic sclerosis: Randomized placebo-controlled trial

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Rheumatology from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW8160 via IFTTT

Allele-specific transcriptional activity of the variable number of tandem repeats of the inducible nitric oxide synthase gene is associated with idiopathic achalasia

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

United European Gastroenterology Journal from #Medicine via ola Kala on Inoreader http://ift.tt/1ZW80Px via IFTTT

IJERPH, Vol. 13, Pages 502: Prevalence and Factors Associated with Substance Use and Misuse among Kosovar Adolescents; Cross Sectional Study of Scholastic, Familial-, and Sports-Related Factors of Influence

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Adolescence is considered to be the most important period for the prevention of substance use and misuse (SUM). The aim of this study was to investigate the problem of SUM and to establish potentially important factors associated with SUM in Kosovar adolescents. Multi-stage simple random sampling was used to select participants. At the end of […]

Why You Should Go Part-Time Vegetarian – Coach

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Coach Why You Should Go Part-Time Vegetarian Coach Research published in May 2016 by the tongue-twisty Journal Of The American Osteopathic Association found that a vegetarian diet increased life expectancy. Collating the data accrued in six different studies across 28 years, the authors found that … and more » from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader […]

Meet the hormone that can make you feel calmer and look younger – Daily Mail

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Daily Mail Meet the hormone that can make you feel calmer and look younger Daily Mail Whether it's running around after children or tearing your hair out at work, stress has increasingly become a part of our busy lives. But while you've probably heard about the stress hormones cortisol and adrenaline, the one that busts […]

Viruses, Vol. 8, Pages 136: The Effect of MicroRNA bantam on Baculovirus AcMNPV Infection in Vitro and in Vivo

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

The role of microRNA bantam, one of the most abundant microRNAs in Sf9 cells, was studied for its role in baculovirus infection in vitro and in vivo. The expression level of bantam was increased after AcMNPV infection in Sf9 cells and in Spodoptera litura larvae. In Sf9 cells, application of bantam inhibitor or mimic altered […]

Physical activity increases after bariatric surgery, review finds

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Physical activity increases in the 12 months after bariatric surgery, shows a systematic review that found that people walked more after undergoing this type of procedure.1A higher level of physical… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/24Ue92a via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Father's age and lifestyle link to birth defects in offspring, review finds

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

A father's age, alcohol use, and exposure to environmental factors have been linked by increasing research evidence to birth defects in his offspring, a review has found, suggesting that these… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1WzX3pp via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

X-ray software delivers 4 bone health measures

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

New software that analyzes bone age and health from hand radiography has revealed… Read more on AuntMinnieEurope.com Related Reading: Lower limb DEXA analysis can boost bone densitometry from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1WBg2PM via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Blepharoplasty with a Buried Double Twisted Suture Technique to Correct Upper Eyelid Epiblepharon

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Background: The authors evaluated the clinical efficacy of blepharoplasty using a newly developed, buried double twisted suture (BDTS) technique to correct upper eyelid epiblepharon. Methods: This retrospective study was conducted from October 2013 to July 2015 at the Oculoplastic Clinic, Bundang CHA Medical Center, CHA University, Seongnam, Korea. A total of 122 eyes from 61 […]

Decompression–Avulsion of the Auriculotemporal Nerve for Treatment of Migraines and Chronic Headaches

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Summary: Surgical decompression of peripheral branches of the trigeminal and occipital nerves has been shown to alleviate migraine symptoms. Site II surgery involves decompression of the zygomaticotemporal branch of the trigeminal nerve by the technique developed by Guyuron. Failure of site II surgery may occur secondary to an inability to recognize a second temporal trigger: […]

BacterioFiles 251 – Mycophagous Myrmicinae Mutualist Microbes

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

This episode: Gut bacteria seem to help ants with very restrictive diets flourish more! (10.6 MB, 11.5 minutes) Show notes: Journal Paper from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Yulguj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Inhibition of fibrous dysplasia via blocking Gs[small alpha] with suramin sodium loaded with an alendronate-conjugated polymeric drug delivery system

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

[image: GA?id=C6BM00091F] *Biomater. Sci.*, 2016, Advance Article *DOI*: 10.1039/C6BM00091F, Paper Mingming Lv, Xiao Li, Yu Huang, Nan Wang, Xinyuan Zhu, Jian Sun A bone-targeted polymeric drug delivery system was constructed to inhibit fibrous dysplasia efficiently *via* blocking Gs[small alpha] with suramin sodium. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/24Uf9TY via IFTTT

OtoRhinoLaryngology & Medicine,New Articles,May 16th,2016

Αλέξανδρος ΣφακιανάκηςστοOtolaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Field treatment of actinic keratosis with ingenol mebutate 0.015 % gel *orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 21 δευτερόλεπτα* *Efficacy, safety and tolerability of field treatment of actinic keratosis with ingenol mebutate 0.015 % gel: a single center case series: Abstract Introduction Actinic keratosis (AK) is a cutaneous intraepithelial neoplasm appearing within areas referred as 'fields of cancerization'. AK can progress to invasive squamous cell carcinoma. Treatments that target both clinically visible and subclinical… Continue reading Field tre... περισσότερα »

OtoRhinoLaryngology,New Articles,May 16th,2016

Αλέξανδρος ΣφακιανάκηςστοOtolaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

09:12 OtoRhinoLaryngology - Alexandros G. Sfakianakis Leptomeningeal metastases from epithelial tumors EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors: BackgroundModerate diagnostic accuracy of MRI and initial cerebrospinal fluid (CSF) cytology analysis results in at least 10%–15% false negative diagnoses of leptomeningeal... 09:12 OtoRhinoLaryngology - Alexandros G. Sfakianakis Differentiating brain tumor progression from radiation injury after cranial irradiation A prospective trial of dyn...περισσότερα »

OtoRhinoLaryngology,New Articles,May 16th,2016

Αλέξανδρος ΣφακιανάκηςστοOtolaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

09:12 OtoRhinoLaryngology - Alexandros G. Sfakianakis Leptomeningeal metastases from epithelial tumors EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors: BackgroundModerate diagnostic accuracy of MRI and initial cerebrospinal fluid (CSF) cytology analysis results in at least 10%–15% false negative diagnoses of leptomeningeal... 09:12 OtoRhinoLaryngology - Alexandros G. Sfakianakis Differentiating brain tumor progression from radiation injury after cranial irradiation A prospective trial of dyn...περισσότερα »

Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Journal of Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1XebcqO via IFTTT

Full title: a meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Pancreatology from #Medicine via ola Kala on Inoreader http://ift.tt/23UxpKy via IFTTT

Multiple hepatitis B virus (HBV) quasispecies and immune-escape mutations are present in HBV surface antigen and reverse transcriptase of patients with acute hepatitis B

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

The Journal of Infectious Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1XebnlS via IFTTT

Biologic therapies and risk of infection and malignancy in patients with inflammatory bowel disease: A systematic review and network meta-analysis

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Clinical Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1XeaN7K via IFTTT

Inflammation to Pulmonary Diseases

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

from Infection via ola Kala on Inoreader http://ift.tt/22dgoMu via IFTTT

Prenatal diagnosis of congenital myopathies and muscular dystrophies

Alexandros G. SfakianakisστοEvolution of a geneΠριν από 1 ώρα

Abstract Congenital myopathies and muscular dystrophies constitute a genetically and phenotypically heterogeneous group of rare inherited diseases characterized by muscle weakness and atrophy, motor delay and respiratory insufficiency. To date, curative care is not available for these diseases, which may severely affect both life-span and quality of life. We discuss prenatal diagnosis and genetic counseling for families at risk, as well as diagnostic possibilities in sporadic cases. [image: Thumbnail image of graphical abstract] Graphical Abstract from Genes via ola Kala on Inorea... περισσότερα »

Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Journal of Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1XebcqO via IFTTT

Full title: a meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Pancreatology from #Medicine via ola Kala on Inoreader http://ift.tt/23UxpKy via IFTTT

Multiple hepatitis B virus (HBV) quasispecies and immune-escape mutations are present in HBV surface antigen and reverse transcriptase of patients with acute hepatitis B

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

The Journal of Infectious Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1XebnlS via IFTTT

Biologic therapies and risk of infection and malignancy in patients with inflammatory bowel disease: A systematic review and network meta-analysis

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα

Clinical Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1XeaN7K via IFTTT

Viruses, Vol. 8, Pages 136: The Effect of MicroRNA bantam on Baculovirus AcMNPV Infection in Vitro and in Vivo

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

The role of microRNA bantam, one of the most abundant microRNAs in Sf9 cells, was studied for its role in baculovirus infection in vitro and in vivo. The expression level of bantam was increased after AcMNPV infection in Sf9 cells and in Spodoptera litura larvae. In Sf9 cells, application of bantam inhibitor or mimic altered […]

Prenatal diagnosis of congenital myopathies and muscular dystrophies

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες

Abstract Congenital myopathies and muscular dystrophies constitute a genetically and phenotypically heterogeneous group of rare inherited diseases characterized by muscle weakness and atrophy, motor delay and respiratory insufficiency. To date, curative care is not available for these diseases, which may severely affect both life-span and quality of life. We discuss prenatal diagnosis and genetic counseling for families at risk, as well as diagnostic possibilities in sporadic cases. [image: Thumbnail image of graphical abstract] Graphical Abstract from Genetics via xlomafota13 on ... περισσότερα »

Hepatitis C virus genotype 4 replication in the hepatocellular carcinoma cell line HepG2/C3A

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες

Saudi Journal of Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Xebrls via IFTTT

FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες

The Lancet Oncology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Xebqy4 via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZWywZh
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