Head and Neck Diseases by Alexandros G.Sfakianakis: 07/12/16

Τρίτη 12 Ιουλίου 2016

Heavy metal contaminations in soil-rice system: source identification in relation to a sulfur-rich coal burning power plant in Northern Guangdong Province, China.

Heavy metal contaminations in soil-rice system: source identification in relation to a sulfur-rich coal burning power plant in Northern Guangdong Province, China.

Environ Monit Assess. 2016 Aug;188(8):460

Authors: Wang X, Zeng X, Chuanping L, Li F, Xu X, Lv Y

Abstract
Heavy metal contents (As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) in 99 pairs of soil-rice plant samples were evaluated from the downwind directions of a large thermal power plant in Shaoguan City, Guangdong Province, China. Results indicate that there is a substantial buildup of As, Cd, Cu, Pb, and Zn in the predominant wind direction of the power plant. The significant correlations between S and heavy metals in paddy soil suggest that the power plant represents a source of topsoil heavy metals in Shaoguan City due to sulfur-rich coal burning emissions. Elevated Cd concentrations were also found in rice plant tissues. Average Cd (0.69 mg kg(-1)) and Pb (0.39 mg kg(-1)) contents in rice grain had exceeded their maximum permissible limits (both were 0.2 mg kg(-1)) in foods of China (GB2762-2005). The enrichment of Cd and Pb in rice grain might pose a potential health risk to the local residents.

PMID: 27395361 [PubMed - as supplied by publisher]

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Microstimulation of the lumbar DRG recruits primary afferent neurons in localized regions of lower limb

Patterned microstimulation of the dorsal root ganglion (DRG) has been proposed as a method for delivering tactile and proprioceptive feedback to amputees. Previous studies demonstrated that large- and medium-diameter afferent neurons could be recruited separately, even several months after implantation. However, those studies did not examine the anatomical localization of sensory fibers recruited by microstimulation in the DRG. Achieving precise recruitment with respect to both modality and receptive field locations will likely be crucial to create a viable sensory neuroprosthesis. In this study, penetrating microelectrode arrays were implanted in the L5, L6, and L7 DRG of four isoflurane-anesthetized cats instrumented with nerve cuff electrodes around the proximal and distal branches of the sciatic and femoral nerves. A binary search was used to find the recruitment threshold for evoking a response in each nerve cuff. The selectivity of DRG stimulation was characterized by the ability to recruit individual distal branches to the exclusion of all others at threshold; 84.7% (n = 201) of the stimulation electrodes recruited a single nerve branch, with 9 of the 15 instrumented nerves recruited selectively. The median stimulation threshold was 0.68 nC/phase, and the median dynamic range (increase in charge while stimulation remained selective) was 0.36 nC/phase. These results demonstrate the ability of DRG microstimulation to achieve selective recruitment of the major nerve branches of the hindlimb, suggesting that this approach could be used to drive sensory input from localized regions of the limb. This sensory input might be useful for restoring tactile and proprioceptive feedback to a lower-limb amputee.

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Skeletal myofiber VEGF regulates contraction-induced perfusion and exercise capacity but not muscle capillarity in adult mice

A single bout of exhaustive exercise signals expression of vascular endothelial growth factor (VEGF) in the exercising muscle. Previous studies have reported that mice with life-long deletion of skeletal myofiber VEGF have fewer capillaries and a severe reduction in endurance exercise. However, in adult mice, VEGF gene deletion conditionally targeted to skeletal myofibers limits exercise capacity without evidence of capillary regression. To explain this, we hypothesized that adult skeletal myofiber VEGF acutely regulates skeletal muscle perfusion during muscle contraction. A tamoxifen-inducible skeletal myofiber-specific VEGF gene deletion mouse (skmVEGF–/–) was used to reduce skeletal muscle VEGF protein by 90% in adult mice. Three weeks after inducing deletion of the skeletal myofiber VEGF gene, skmVEGF–/– mice exhibited diminished maximum running speed (–10%, P < 0.05) and endurance capacity (–47%; P < 0.05), which did not persist after 8 wk. In skmVEGF–/– mice, gastrocnemius complex time to fatigue measured in situ was 71% lower than control mice. Contraction-induced perfusion measured by optical imaging during a period of electrically stimulated muscle contraction was 85% lower in skmVEGF–/– than control mice. No evidence of capillary rarefication was detected in the soleus, gastrocnemius, and extensor digitorum longus (EDL) up to 8 wk after tamoxifen-induced VEGF ablation, and contractility and fatigue resistance of the soleus measured ex vivo were also unchanged. The force-frequency of the EDL showed a small right shift, but fatigue resistance did not differ between EDL from control and skmVEGF–/– mice. These data suggest myofiber VEGF is required for regulating perfusion during periods of contraction and may in this manner affect endurance capacity.

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The role of the rectum in osmoregulation and the potential effect of renoguanylin on SLC26a6 transport activity in the Gulf toadfish (Opsanus beta)

Teleosts living in seawater continually absorb water across the intestine to compensate for branchial water loss to the environment. The present study reveals that the Gulf toadfish (Opsanus beta) rectum plays a comparable role to the posterior intestine in ion and water absorption. However, the posterior intestine appears to rely more on SLC26a6 (a HCO₃^–/Cl^– antiporter) and the rectum appears to rely on NKCC2 (SLC12a1) for the purposes of solute-coupled water absorption. The present study also demonstrates that the rectum responds to renoguanylin (RGN), a member of the guanylin family of peptides that alters the normal osmoregulatory processes of the distal intestine, by inhibited water absorption. RGN decreases rectal water absorption more greatly than in the posterior intestine and leads to net Na⁺ and Cl^– secretion, and a reversal of the absorptive short-circuit current (I_SC). It is hypothesized that maintaining a larger fluid volume within the distal segments of intestinal tract facilitates the removal of CaCO₃ precipitates and other solids from the intestine. Indeed, the expression of the components of the Cl^–-secretory response, apical CFTR, and basolateral NKCC1 (SLC12a2), are upregulated in the rectum of the Gulf toadfish after 96 h in 60 ppt, an exposure that increases CaCO₃ precipitate formation relative to 35 ppt. Moreover, the downstream intracellular effects of RGN appear to directly inhibit ion absorption by NKCC2 and anion exchange by SLC26a6. Overall, the present findings elucidate key electrophysiological differences between the posterior intestine and rectum of Gulf toadfish and the potent regulatory role renoguanylin plays in osmoregulation.

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Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep

Hepatic glucose production (HGP) normally begins just prior to birth. Prolonged fetal hypoglycemia, intrauterine growth restriction, and acute hypoxemia produce an early activation of fetal HGP. To test the hypothesis that prolonged hypoxemia increases factors which regulate HGP, studies were performed in fetuses that were bled to anemic conditions (anemic: n = 11) for 8.9 ± 0.4 days and compared with control fetuses (n = 7). Fetal arterial hematocrit and oxygen content were 32% and 50% lower, respectively, in anemic vs. controls (P < 0.005). Arterial plasma glucose was 15% higher in the anemic group (P < 0.05). Hepatic mRNA expression of phosphonenolpyruvate carboxykinase (PCK1) was twofold higher in the anemic group (P < 0.05). Arterial plasma glucagon concentrations were 70% higher in anemic fetuses compared with controls (P < 0.05), and they were positively associated with hepatic PCK1 mRNA expression (P < 0.05). Arterial plasma cortisol concentrations increased 90% in the anemic fetuses (P < 0.05), but fetal cortisol concentrations were not correlated with hepatic PCK1 mRNA expression. Hepatic glycogen content was 30% lower in anemic vs. control fetuses (P < 0.05) and was inversely correlated with fetal arterial plasma glucagon concentrations. In isolated primary fetal sheep hepatocytes, incubation in low oxygen (3%) increased PCK1 mRNA threefold compared with incubation in normal oxygen (21%). Together, these results demonstrate that glucagon and PCK1 may potentiate fetal HGP during chronic fetal anemic hypoxemia.

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Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity

The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic ATP production and is the only metabolic pathway with proteins encoded by both nuclear and mitochondrial genomes. In studies examining mitonuclear interactions among distant populations within a species or across species, the interactions between these two genomes can affect metabolism, growth, and fitness, depending on the environment. However, there is little data on whether these interactions impact natural populations within a single species. In an admixed Fundulus heteroclitus population with northern and southern mitochondrial haplotypes, there are significant differences in allele frequencies associated with mitochondrial haplotype. In this study, we investigate how mitochondrial haplotype and any associated nuclear differences affect six OxPhos parameters within a population. The data demonstrate significant OxPhos functional differences between the two mitochondrial genotypes. These differences are most apparent when individuals are acclimated to high temperatures with the southern mitochondrial genotype having a large acute response and the northern mitochondrial genotype having little, if any acute response. Furthermore, acute temperature effects and the relative contribution of Complex I and II depend on acclimation temperature: when individuals are acclimated to 12°C, the relative contribution of Complex I increases with higher acute temperatures, whereas at 28°C acclimation, the relative contribution of Complex I is unaffected by acute temperature change. These data demonstrate a complex gene by environmental interaction affecting the OxPhos pathway.

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Deletion of novel protein TMEM35 alters stress-related functions and impairs long-term memory in mice

The mounting of appropriate emotional and neuroendocrine responses to environmental stressors critically depends on the hypothalamic-pituitary-adrenal (HPA) axis and associated limbic circuitry. Although its function is currently unknown, the highly evolutionarily conserved transmembrane protein 35 (TMEM35) is prominently expressed in HPA circuitry and limbic areas, including the hippocampus and amygdala. To investigate the possible involvement of this protein in neuroendocrine function, we generated tmem35 knockout (KO) mice to characterize the endocrine, behavioral, electrophysiological, and proteomic alterations caused by deletion of the tmem35 gene. While capable of mounting a normal corticosterone response to restraint stress, KO mice showed elevated basal corticosterone accompanied by increased anxiety-like behavior. The KO mice also displayed impairment of hippocampus-dependent fear and spatial memories. Given the intact memory acquisition but a deficit in memory retention in the KO mice, TMEM35 is likely required for long-term memory consolidation. This conclusion is further supported by a loss of long-term potentiation in the Schaffer collateral-CA1 pathway in the KO mice. To identify putative molecular pathways underlying alterations in plasticity, proteomic analysis of synaptosomal proteins revealed lower levels of postsynaptic molecules important for synaptic plasticity in the KO hippocampus, including PSD95 and N-methyl-d-aspartate receptors. Pathway analysis (Ingenuity Pathway Analysis) of differentially expressed synaptic proteins in tmem35 KO hippocampus implicated molecular networks associated with specific cellular and behavioral functions, including decreased long-term potentiation, and increased startle reactivity and locomotion. Collectively, these data suggest that TMEM35 is a novel factor required for normal activity of the HPA axis and limbic circuitry.

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Assessing heavy metal sources in sugarcane Brazilian soils: an approach using multivariate analysis.

Assessing heavy metal sources in sugarcane Brazilian soils: an approach using multivariate analysis.

Environ Monit Assess. 2016 Aug;188(8):457

Authors: da Silva FB, do Nascimento CW, Araújo PR, da Silva LH, da Silva RF

Abstract
Brazil is the world's largest sugarcane producer and soils in the northeastern part of the country have been cultivated with the crop for over 450 years. However, so far, there has been no study on the status of heavy metal accumulation in these long-history cultivated soils. To fill the gap, we collect soil samples from 60 sugarcane fields in order to determine the contents of Cd, Cr, Cu, Ni, Pb, and Zn. We used multivariate analysis to distinguish between natural and anthropogenic sources of these metals in soils. Analytical determinations were performed in ICP-OES after microwave acid solution digestion. Mean concentrations of Cd, Cr, Cu, Ni, Pb, and Zn were 1.9, 18.8, 6.4, 4.9, 11.2, and 16.2 mg kg(-1), respectively. The principal component one was associated with lithogenic origin and comprised the metals Cr, Cu, Ni, and Zn. Cluster analysis confirmed that 68 % of the evaluated sites have soil heavy metal concentrations close to the natural background. The Cd concentration (principal component two) was clearly associated with anthropogenic sources with P fertilization being the most likely source of Cd to soils. On the other hand, the third component (Pb concentration) indicates a mixed origin for this metal (natural and anthropogenic); hence, Pb concentrations are probably related not only to the soil parent material but also to industrial emissions and urbanization in the vicinity of the agricultural areas.

PMID: 27395358 [PubMed - as supplied by publisher]

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Multiscale entropy analysis of heart rate variability in heart failure, hypertensive, and sinoaortic-denervated rats: classical and refined approaches

The analysis of heart rate variability (HRV) by nonlinear methods has been gaining increasing interest due to their ability to quantify the complexity of cardiovascular regulation. In this study, multiscale entropy (MSE) and refined MSE (RMSE) were applied to track the complexity of HRV as a function of time scale in three pathological conscious animal models: rats with heart failure (HF), spontaneously hypertensive rats (SHR), and rats with sinoaortic denervation (SAD). Results showed that HF did not change HRV complexity, although there was a tendency to decrease the entropy in HF animals. On the other hand, SHR group was characterized by reduced complexity at long time scales, whereas SAD animals exhibited a smaller short- and long-term irregularity. We propose that short time scales (1 to 4), accounting for fast oscillations, are more related to vagal and respiratory control, whereas long time scales (5 to 20), accounting for slow oscillations, are more related to sympathetic control. The increased sympathetic modulation is probably the main reason for the lower entropy observed at high scales for both SHR and SAD groups, acting as a negative factor for the cardiovascular complexity. This study highlights the contribution of the multiscale complexity analysis of HRV for understanding the physiological mechanisms involved in cardiovascular regulation.

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Safety assessment of a traditionally used extract from leaves of Boldoa purpurascens.

Safety assessment of a traditionally used extract from leaves of Boldoa purpurascens.

J Ethnopharmacol. 2016 Jul 6;

Authors: Ortega YH, Mosquera DM, Galapththi S, Santos BT, González GS, Foubert K, Pieters L, Calderon PB, Apers S

Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Boldoa purpurascens Cav. (Nyctaginaceae) is a plant species used in traditional medicine in Cuba as a diuretic.
AIM OF THE STUDY: The aim of the present investigation was to evaluate the safety profile of a hydroalcoholic extract from leaves of Boldoa purpurascens.
MATERIALS AND METHODS: First, an experimental study to assess the oral acute toxicity at a dose of 2000mg/kg body weight of the extract was carried out. Potential genotoxicity of the extract was evaluated using the Ames test and the micronucleus induction assay in mouse bone marrow. In the Ames test a concentration range of 50, 100, 150, 300 and 500µg/plate was tested. In the micronucleus induction assay, doses of 500, 1000 and 2000mg/kg of body weight were tested. For completeness, since the extract contains saponins, the evaluation of the hemolytic activity, ocular and skin irritation were included.
RESULTS: No signs or symptoms of toxicity were observed in the oral acute toxicity test (body weight at baseline, seven days and end of the experiment of 236.41 ± 20.07, 256.81 ± 30.44 and 240.02± 26.16 respectively for the treated group). The hydroalcoholic extract from the leaves was not mutagenic in the Ames test, and no genotoxicity was observed in the micronucleus assay. A hemolysis test at concentration of 1mg/mL confirmed hemolytic activity, which is not a safety concern since saponins are not absorbed after oral administration. In order to evaluate the percentage of protein denaturation, the ocular irritability index was calculated. The extract was found to be irritating. Finally, skin irritability was evaluated and the irritation index was equal to zero.
CONCLUSIONS: Based on the toxicological evaluation of a traditionally used hydroalcoholic extract from the leaves of Boldoa purpurascens we can confirm the safety of its oral use.

PMID: 27394387 [PubMed - as supplied by publisher]

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Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases

Abstract

Salivary gland-type tumors have been rarely described in the thyroid gland. Mammary Analog Secretory Carcinoma (MASC) is a recently defined type of salivary gland carcinoma characterized by a t(12;15)(p13;q25) resulting in an ETV6-NTRK3 fusion gene. We report 3 cases of MASC involving the thyroid gland without clinical evidence of a salivary gland or breast primary; the clinico-pathologic characteristics are reviewed. Assessment for rearrangement of the ETV6 (12p13) locus was conducted by fluorescence in situ hybridization (FISH) on representative FFPE sections using an ETV6 break apart probe (Abbott Molecular, Des Plaines, IL, USA). The patients were two females (52 and 55 years-old) and 1 male (74 years-old). The tumors were poorly circumscribed solid white tan nodules involving the thyroid. Histologically, they were invasive and showed solid, microcystic, cribriform, and tubular growth patterns composed of variably bland polygonal eosinophilic cells with vesicular nuclear chromatin and conspicuous nucleoli. All three cases showed metastasis to lymph nodes; one case showed lateral neck involvement. The tumor cells were positive for S100 and mammaglobin. GATA-3 and PAX-8 were positive in 2 cases, one of which only focally so. All three cases were negative for TTF-1 and thyroglobulin. Rearrangement of the ETV6 locus was confirmed in all cases and a diagnosis of MASC rendered for each case. A site of origin distinct from the thyroid gland was not identified, with a median follow up of 24 months. MASC may rarely involve the thyroid gland. The origin of these lesions is unknown; while an origin from ectopic salivary gland-type cells is entertained, a metastatic origin from an occult primary cannot be definitively excluded at this time. Given the histologic (follicular-like microcystic pattern with colloid-like secretions and papillary pattern), immunophenotypic (PAX-8), and even molecular overlap, MASC can be mistaken for papillary thyroid carcinoma and should be considered in the differential diagnosis of a thyroid mass.

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Deposition of radiocesium on the river flood plains around Fukushima

Publication date: November 2016
Source:Journal of Environmental Radioactivity, Volume 164
Author(s): Hiromitsu Saegusa, Takuya Ohyama, Kazuki Iijima, Hironori Onoe, Ryuji Takeuchi, Hiroki Hagiwara
The environment in the area around Fukushima Daiichi Nuclear Power Plant has been contaminated by widely deposited significant amount of radioactive materials, which were released to the atmosphere caused by the Fukushima Daiichi Nuclear Power Plant accident due to the Great East Japan Earthquake, which occurred on March 11, 2011. The radiocesium released in the accident mainly affects radiation dose in the environment. Decontamination work in the contaminated area except a mountain forests has been conducted to decrease the radiation dose. However, there are concerns that the redistribution of this radiation due to water discharge will occur due to the resulting transport of radiocesium. In particular, the deposition of soil particles containing radiocesium on the flood plains in the downstream areas of Fukushima's rivers can potentially increase the local radiation dose. Therefore, it is important to understand the influence of the deposition behavior of radiocesium on the radiation dose.Investigations of rivers have been performed to enhance the understanding of the mechanisms by which radiocesium is deposited on these flood plains. It was found that the spatial distribution of the radiocesium concentration on the flood plain along the river is heterogeneous with a dependence on the depositional condition and that the number of points with high air dose rates is limited. In detail, the radiocesium concentration and air dose rates in flood channels are higher than those at the edges of the river channels. Based on these heterogeneity and hydrological events, the deposition and transport mechanisms of the radiocesium due to water discharge at rivers were also interpreted, and a conceptual model was constructed.

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Journal of Perioperative Echocardiography

Table of Contents

1. EDITORIAL

Editorial

Kathirvel Subramaniam

1-2

Full Text PDF | Abstract | 10.5005/jp-journals-10034-1043 |

2. REVIEW ARTICLE

Perioperative Ultrasonography Review

Nicholas J Schott, Christopher K Schott

3-9

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10034-1044 |

3. CASE REPORT

Echocardiographic Evaluation and Management of Right Ventricular Dysfunction during Cardiac Transplantation

Alok Kumar, VK Arya, Ajay Kumar, Goverdhan Dutt Puri, KST Shyam, Ajay Bahl

10-13

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10034-1045 |

4. CASE REPORT

Perioperative Transesophageal Echocardiographic Diagnosis of Membranous Interventricular Septal Aneurysm in Two Patients

Vikas Dutta, Sunder L Negi, Goverdhan Dutt Puri, Rana S Singh

14-16

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10034-1046 |

5. CASE REPORT

Pulmonary Artery Perforation: Rare reported Complication of Pericardiectomy for Chronic Constrictive Pericarditis recorded on Transesophageal Echocardiography

Neeti Makhija, Jitin Narula, Sanjay Kumar, Sameer Taneja, Milind P Hote

17-18

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10034-1047 |

6. CASE REPORT

Role of Perioperative Echocardiographic in Surgical Correction of the Pulmonary Venous Anomalies (with Invited Commentary by Professor Rupa Sreedhar)

Alok Kumar, Vikas Dutta, Sunder Negi, Goverdhan Dutt Puri

19-26

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10034-1048 |

7. CASE REPORT

Transesophageal Echocardiographic Evaluation of Crisscross Heart with Atrioventricular Valve Regurgitation for Fontan Procedure

Neeti Makhija, Vandana Bhardwaj, Anita Saxena, Sachin Talwar

27-29

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10034-1049 |

8. CASE REPORT

Unusual Attachment of Left Atrial Myxoma: Role of Transesophageal Echocardiography

Neeti Makhija, Kalpna Irpachi, Ujjwal K Chowdhury, Usha Kiran

30-33

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10034-1050 |

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Botanical Drugs in Ayurveda and Traditional Chinese Medicine.

Botanical Drugs in Ayurveda and Traditional Chinese Medicine.

J Ethnopharmacol. 2016 Jul 6;

Authors: Jaiswal Y, Liang Z, Zhao Z

Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: China and India have a long history in the therapeutic application of botanical drugs in traditional medicine. Traditional Chinese Medicine (TCM) and Ayurveda are considered as two of the most ancient systems of medicine, with history of more than two millennia. Medicinal plants are the principal medicinal materials used in both these systems.
AIM OF THE REVIEW: This review discusses about the histories of Ayurveda and TCM, the common medicinal plants species, the drug processing strategies used, and the current statuses of these traditional systems of medicine (TSM). Through the views presented in this article, we aim to provide a new perspective to herbal drug researchers for expanding and improving the utilization of botanical drugs and their therapeutic applications.
METHODS: A bibliographic investigation of Chinese and Indian pharmacopoeias, monographs and official websites was performed. Furthermore, information was obtained from scientific databases on ethnobotany and ethno medicines.
RESULTS: The review of Ayurveda and TCM ethno medicine indicates that both these systems have many medicinal materials in common. The studies carried out by the authors for comparison of plants from same genus from both these TSM's have been discussed to further bring focus to the utilization of "qualitatively" similar species which can be utilized and substituted for endangered or economically valued species. The overview of ancient literature and scientific findings for drugs in both these systems suggests that, the botanical drugs used in common and their processing methods can be explored further for extensive utilization in traditional medicine.
CONCLUSION: This review describes the histories, common medicinal plant species, their processing methods and therapeutic applications in Ayurveda and TCM. The insights provided through this article may be used by herbal drug researchers and pharmacologists for further exploration of botanical drugs from these two traditional systems of medicine.

PMID: 27394388 [PubMed - as supplied by publisher]

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Possible similarities between the folk medicine historically used by First Nations and American Indians in North America and the ethnoveterinary knowledge currently used in British Columbia, Canada.

Possible similarities between the folk medicine historically used by First Nations and American Indians in North America and the ethnoveterinary knowledge currently used in British Columbia, Canada.

J Ethnopharmacol. 2016 Jul 6;

Authors: Lans C

Abstract
AIMS OF THE STUDY: This paper compares sixty-four plants used as ethnoveterinary remedies in British Columbia with First Nations folk medicine.
MATERIALS AND METHODS: In 2003 I conducted semi-structured interviews with 60 participants obtained using a purposive sample. The data was then compared with historical documents on First Nations plant use.
RESULTS: Exact parallels between First Nations/ native American folk medicine and ethnoveterinary remedies used for farm animals and horses were Acer macrophyllum Pursh, Epilobium angustifolium L. and Lonicera involucrata (Richardson) Banks ex Spreng., used as stimulants and tonics for goats; Achlys tripylla DC. as a fly repellent in barns, Alnus rubra Bong., for rabbits' dental care, Berberis repens Lindl., Rumex crispus L., to treat sores and rashes on horses, Pinus ponderosa Douglas ex C. Lawson for stomach problems and Bovista pila Berk. & M.A. Curtis and Dolichousnea longissima (Ach.) Articus used on wounds.
CONCLUSION: This study revealed the parallel uses between sixty-four plants used as ethnoveterinary medicines in British Columbia and the folk medicines used by the First Nations peoples and by native American groups.

PMID: 27394389 [PubMed - as supplied by publisher]

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Water quality of the main tributaries of the Paraná Basin: glyphosate and AMPA in surface water and bottom sediments.

Water quality of the main tributaries of the Paraná Basin: glyphosate and AMPA in surface water and bottom sediments.

Environ Monit Assess. 2016 Aug;188(8):458

Authors: Ronco AE, Marino DJ, Abelando M, Almada P, Apartin CD

Abstract
The Paraná River, the sixth largest in the world, is the receptor of pollution loads from tributaries traversing urban and industrialized areas plus agricultural expanses, particularly so in the river's middle and lower reaches along the Argentine sector. In the present study, we analyzed and discussed the main water quality parameters, sediment compositions, and content of the herbicide glyphosate plus its metabolite aminomethylphosphonic acid (AMPA) in water and sediments. Samples were obtained from distal positions in the principal tributaries of the Paraná and the main watercourse during surveys conducted in 2011 and 2012 to monitor the basin. Only 15 % of the water samples contained detectable concentrations of glyphosate at an average concentration of 0.60 μg/L, while no detectable levels of AMPA were observed. The herbicide and metabolite were primarily present in sediments of the middle and lower stretch's tributaries, there occurring at a respective average of 37 and 17 % in samples. The mean detectable concentrations measured were 742 and 521 μg/kg at mean, maximum, and minimum glyphosate/AMPA ratios of 2.76, 7.80, and 0.06, respectively. The detection of both compounds was correlated with the presence of sulfides and copper in the sediment matrix.

PMID: 27395359 [PubMed - as supplied by publisher]

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Adverse effect of agroecosystem pond water on biological endpoints of common toad (Rhinella arenarum) tadpoles.

Adverse effect of agroecosystem pond water on biological endpoints of common toad (Rhinella arenarum) tadpoles.

Environ Monit Assess. 2016 Aug;188(8):459

Authors: Babini MS, Bionda CL, Salas NE, Martino AL

Abstract
Chemical prroducts used in farming and wastes from livestock can contaminate pond water in agroecosystems due to runoff. Amphibians using these ponds for breeding are probably exposed to pollutants, and serious consequences might be observed afterward at the population level. Assessment biological endpoints of anuran to water quality give a realistic estimate of the probability of occurrence of adverse effects and provide an early warning signal. In this study, the ecotoxicity of agroecosystem ponds from the south of Córdoba province, Argentina, was investigated. Ponds in four sites with different degrees of human disturbance were selected: three agroecosystems (A1, A2, A3) and a site without crops or livestock (SM). The effect of pond water quality on the biological endpoint of Rhinella arenarum tadpoles was examined using microcosms with pond water from sites. Biological endpoints assessed were as follows: mortality, growth, development, morphological abnormalities (in body shape, gut, and labial tooth row formula), behavior, and blood cell parameters (micronucleus and nuclear abnormalities). Results indicated that water from agroecosystems has adverse effect on early life stage of R. arenarum. High mortality and fewer metamorphs were recorded in the A1 and A3 treatments. Tadpoles and metamorphs from A1 and A2 treatments had lower body condition. Tadpoles from A1 and A3 showed the highest prevalence of morphological abnormalities. The lowest amount of tadpoles feeding and the highest percentage of tadpoles swimming on the surface were observed in treatments with agroecosystem pond water. The higher frequencies of micronuclei and nuclear abnormalities were recorded in tadpoles from A1, A2, and A3 treatments. We check the sensitivity of the biological endpoints of R. arenarum tadpoles like early warning indicators of water quality. We found that the poor water quality of agroecosystem ponds has impact on the health of the tadpoles, and this could affect the persistence of populations. We recommend implementation of management actions before the harmful effects of agroecosystem pond water on early life stage of anuran become evident in higher ecological levels.

PMID: 27395360 [PubMed - as supplied by publisher]

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Heavy metal contaminations in soil-rice system: source identification in relation to a sulfur-rich coal burning power plant in Northern Guangdong Province, China.

Heavy metal contaminations in soil-rice system: source identification in relation to a sulfur-rich coal burning power plant in Northern Guangdong Province, China.

Environ Monit Assess. 2016 Aug;188(8):460

Authors: Wang X, Zeng X, Chuanping L, Li F, Xu X, Lv Y

PMID: 27395361 [PubMed - as supplied by publisher]

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Assessing heavy metal sources in sugarcane Brazilian soils: an approach using multivariate analysis.

Assessing heavy metal sources in sugarcane Brazilian soils: an approach using multivariate analysis.

Environ Monit Assess. 2016 Aug;188(8):457

Authors: da Silva FB, do Nascimento CW, Araújo PR, da Silva LH, da Silva RF

PMID: 27395358 [PubMed - as supplied by publisher]

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Safety assessment of a traditionally used extract from leaves of Boldoa purpurascens.

Safety assessment of a traditionally used extract from leaves of Boldoa purpurascens.

J Ethnopharmacol. 2016 Jul 6;

Authors: Ortega YH, Mosquera DM, Galapththi S, Santos BT, González GS, Foubert K, Pieters L, Calderon PB, Apers S

PMID: 27394387 [PubMed - as supplied by publisher]

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Differential responses to vitamin D2 and vitamin D3 are associated with variations in free 25-hydroxyvitamin D

Rene F Chun, et al. | Endocrinology | Jul 11, 2016

Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW) and Their Receptors in Chickens: Evidence for NPW being a Novel Inhibitor of Pituitary Growth Hormone and Prolactin Secretion

Guixian Bu, et al. | Endocrinology | Jul 11, 2016

The NADPH oxidase Nox2 mediates Vitamin D-induced vascular regeneration in male mice

Matthias S. Leisegang, et al. | Endocrinology | Jul 11, 2016

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ACR Appropriateness Criteria Management of Recurrent Endometrial Cancer.

Objectives: In women with endometrial carcinoma (EC), tumor recurrences tend to occur in the 2- to 3-year period following surgical staging. Management of disease recurrence in EC poses significant challenges. These patients represent a heterogenous group where histologic subtypes, previous adjuvant management, interval since completion of adjuvant therapy, and size and site(s) of disease recurrence all have important implications on salvage therapies and prognosis. No randomized controlled trials have been published to determine optimal management in this group of patients. An expert panel was convened to reach consensus on the most appropriate management options in this group of patients. Methods: The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment. Results: Five clinical variants were developed to address common scenarios in the management of women with recurrent EC. Group members reached consensus on the appropriateness of specific evaluation and treatment approaches with numerical ratings. Conclusions: In combining available medical literature and expert opinions, this manuscript may serve as an aid for other practitioners in the appropriate management of women with recurrent EC. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

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Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice

Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice:

Abstract

The understanding of the molecular mechanisms of the immune tolerance induced by the tumoral microenvironment is fundamental to prevent cancer development or to treat cancer patients using immunotherapy. Actually, there are investigations about "addressed-drugs" against cancer cells without affecting normal cells. It could be ideal to find selective and specific compounds that only recognize and destroy tumor cells without damaging the host normal cells. For thousands of years, mushrooms have been used for medicinal purposes because of their curative properties. D-Fraction, an extract of Maitake (from the edible Grifola frondosa mushroom), rich in β-glucans, exert notable effects in the immune system. Until now, some published articles suggest that Maitake D-Fraction could have anti-tumoral activity, prevent oncogenesis and metastasis in some tumor types. However, there are no clear data about Maitake D-Fraction action on breast cancer prevention and its exact molecular mechanisms are not yet elucidated. The experiments were performed employing 25 female BALBc mice that were treated with and without Maitake D-Fraction Pro4X or Maitake Standard for 15 days by daily intraperitoneal injection. After treatment period, all mice were implanted with murine tumor cells LM3 to induce mammary tumorigenesis. Animals were checked weekly and killed after 46 days of LM3 transplant; percentage of cancer prevention, rate of tumor growing, and overall survival were determined. Under dissection, the internal organs were evaluated histologically and genetically by RT-PCR. We found that 5 mg/kg per day of Maitake D-Fraction Pro4X, administered dairy during 15 days to BALBc mice was able to block more than 60% breast cancer development. However, Maitake Standard prevents oncogenesis in 26% to respect control. In this work, we found that Maitake D-Fraction Pro4X, administered to BALBc mice, prevents breast carcinogenesis, block tumor invasiveness, reduce angiogenesis, and increase overall survival.

In this work, we found that Maitake D-Fraction, administered to BALBc mice, prevents breast carcinogenesis, block tumor invasiveness, reduce angiogenesis, and increase overall survival.

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SHP-1 promoter 2 methylation in cerebrospinal fluid for diagnosis of leptomeningeal epithelial-derived malignancy (carcinomatous meningitis)

SHP-1 promoter 2 methylation in cerebrospinal fluid for diagnosis of leptomeningeal epithelial-derived malignancy (carcinomatous meningitis):

Abstract

Current diagnostic methods for leptomeningeal metastasis (LM) from epithelial-derived malignancy (EDM) have limited sensitivity. Here, we explored SHP-1 promoter 2 methylation (SHP1P2)—an epithelial-specific methylation marker previously proven as risk stratification and potential diagnostic marker in non-small cell lung cancer—for EDM with LM. We prospectively recruited 136 patients who were diagnosed EDM with LM (n = 25), EDM without LM (n = 14), non-EDM with LM (n = 8), and benign meningeal diseases (n = 89). The primary cancer sites for EDM with LM were lung (n = 17), breast (n = 5), and colon (n = 3). We performed quantitative analyses of cell-free (cfSHP1P2) and whole fraction (wSHP1P2) from cerebrospinal fluid (CSF); results were correlated with the clinicopathological data, including CSF cytology. Median cfSHP1P2 and wSHP1P2 were 3.08 [range: 0–163.5] and 9.35 [0.69–91.63] ng/ml, respectively, in EDM with LM; 0 [0–0.08] and 0.23 [0–7.84] ng/ml in EDM without LM; and were undetectable in most cases of benign meningeal diseases and non-EDM with LM. The cut-off values of 0.22 ng/ml for methylated cfSHP1P2 and 0.59 ng/ml for wSHP1P2 were the best to discriminate EDM with LM from EDM without LM (sensitivity: 79–100 %; specificity: 83–100 %), as well as from other benign conditions (sensitivity: 85–100 % specificity: 78–100 %). CSF cytology yielded 76 % sensitivity for diagnosing EDM with LM. Further validation of CSF SHP1P2 methylation detection as a role of adjunctive tool for LM from EDM should be interested based on our study.

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Impact of gross total resection in patients with WHO grade III glioma harboring the IDH 1/2 mutation without the 1p/19q co-deletion

Impact of gross total resection in patients with WHO grade III glioma harboring the IDH ½ mutation without the 1p/19q co-deletion:

Abstract

The prognosis of patients with WHO grade III gliomas is highly dependent on their genomic status such as the isocitrate dehydrogenase (IDH) ½ mutation and1p/19q co-deletion. However, difficulties have been associated with determining which tumors have certain genomic profiles by preoperative radiographical modalities, and the role of surgical resection in achieving better outcomes remains unclear. This retrospective study included 124 consecutive patients with newly diagnosed grade III gliomas. The genomic status of IDH1/2 and 1p/19q was analyzed in these patients. Tumors were then divided into 3 subgroups based on their genomic status; the IDH ½ mutation with the 1p/19q co-deletion (1p/19q co-del), the IDH ½ mutation without the 1p/19q co-deletion (non-1p/19q co-del), and the IDH ½ wild type (IDH wt). Survival times were compared between patients who underwent gross total resection and those who did not (GTR versus non-GTR). The relationships between genomic statuses and MR imaging characteristics such as ring-like or nodular enhancements by gadolinium, and very low intensity on T1-weighted images with blurry enhancements (T1VL) were also examined. Among all patients with grade III gliomas, GTR patients had longer median survival and progression-free times than those of non-GTR patients (undefined versus 87 months, p = 0.097, and 124 versus 34 months, p = 0.059, respectively). No significant differences were observed in survival between GTR and non-GTR patients in the 1p/19q co-del group (p = 0.14), or between GTR and non-GTR patients in the IDH wt group (26 and 27 months, p = 0.29). On the other hand, in non-1p/19q co-del group, survival was significantly longer in GTR patients than in non-GTR patients (undefined versus 77 months, p = 0.005). Radiographically, T1VL was detected in most tumors in the non-1p/19q co-del group (78.2 %), but only 6 (21.4 %) and 17 (41.5 %) tumors in the 1p/19q co-del and IDH wt groups, respectively. A correlation was not found between other genomic subgroups and MR imaging findings. Strict surgical removal is important to improve the prognosis of patients with grade III gliomas, especially for tumors with the IDH ½ mutation without the 1p/19q co-deletion. The MR finding of T1VL can be used to select candidates for more radical resection.

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Utilization and impact of adjuvant therapy in anaplastic oligodendroglioma: an analysis on 1692 patients

Utilization and impact of adjuvant therapy in anaplastic oligodendroglioma: an analysis on 1692 patients:

Abstract

The aim of this study was to determine the utilization rates and impact of adjuvant therapy on overall survival (OS) for anaplastic oligodendroglioma (AO). Data were extracted from the National Cancer Data Base (NCDB). Chi square test, Kaplan–Meier method, and Cox regression models were employed in SPSS 22.0 (Armonk, NY: IBM Corp.) for data analyses. 1692 patients with AO who underwent surgery were identified. 945 (55.9 %) received adjuvant radiotherapy with concomitant chemotherapy (chemoRT), 102 (6.0 %) adjuvant radiotherapy (RT) sequentially followed by chemotherapy, 244 (14.4 %) adjuvant RT alone, and 401 (23.7 %) received no adjuvant therapy. Patients were more likely to receive adjuvant chemoRT if they were diagnosed in 2009-2013 vs. 2004–2008 (p 70 vs.

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Anaplastic astrocytoma: prognostic factors and survival in 4807 patients with emphasis on receipt and impact of adjuvant therapy

Anaplastic astrocytoma: prognostic factors and survival in 4807 patients with emphasis on receipt and impact of adjuvant therapy:

Abstract

To determine the receipt and impact of adjuvant therapy on overall survival (OS) for anaplastic astrocytoma (AA). Data were extracted from the National Cancer Data Base (NCDB). Chi square test, Kaplan–Meier method, and Cox regression models were employed in SPSS 22.0 (Armonk, NY: IBM Corp.) for data analyses. 4807 patients with AA diagnosed from 2004 to 2013 who underwent surgery were identified. 3243 (67.5 %) received adjuvant chemoRT, 525 (10.9 %) adjuvant radiotherapy (RT) alone, 176 (3.7 %) adjuvant chemotherapy alone and 863 (18.0 %) received no adjuvant therapy. Patients were more likely to receive adjuvant chemoRT if they were diagnosed in 2009-2013 (p = 0.022), were ≤ 50 years (p

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Composition chimique et activité antibactérienne de l’huile essentielle de Teucrium polium L. du mont de Tessala (Algérie occidentale)

Résumé

L'extraction de l'huile essentielle de Teucrium polium L. par hydrodistillation a permis d'obtenir un rendement moyen de 1,66 ± 0,12 %. Sa caractérisation par chromatographie en phase gazeuse couplée à la spectrométrie de masse montre une dominance des composés hydrocarbonés (77,85 %), avec 43,41 % de carbures monoterpéniques et 34,44 de carbures sesquiterpéniques. Les monoterpènes et les sesquiterpènes oxygénés révèlent un taux global de 20,31 %. L'activité antibactérienne montre une importante efficacité vis-à-vis des souches testées (75 % de sensibilité). Staphylococcus aureus enregistre le plus haut taux de sensibilité (100 %); Escherichia coli, Proteus mirabilis et Pseudomonas aeruginosa exhibent une résistance (33,33 %) visà- vis de l'huile essentielle. La concentration minimale inhibitrice est de 31,5 μl/ml, notée pour la souche Staphylococcus aureus. Cette inhibition est considérée comme très forte.

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Differential responses to vitamin D2 and vitamin D3 are associated with variations in free 25-hydroxyvitamin D

Rene F Chun, et al. | Endocrinology | Jul 11, 2016

Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW) and Their Receptors in Chickens: Evidence for NPW being a Novel Inhibitor of Pituitary Growth Hormone and Prolactin Secretion

Guixian Bu, et al. | Endocrinology | Jul 11, 2016

The NADPH oxidase Nox2 mediates Vitamin D-induced vascular regeneration in male mice

Matthias S. Leisegang, et al. | Endocrinology | Jul 11, 2016

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ACR Appropriateness Criteria Management of Recurrent Endometrial Cancer.

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Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice

Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice:

Abstract

In this work, we found that Maitake D-Fraction, administered to BALBc mice, prevents breast carcinogenesis, block tumor invasiveness, reduce angiogenesis, and increase overall survival.

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SHP-1 promoter 2 methylation in cerebrospinal fluid for diagnosis of leptomeningeal epithelial-derived malignancy (carcinomatous meningitis)

SHP-1 promoter 2 methylation in cerebrospinal fluid for diagnosis of leptomeningeal epithelial-derived malignancy (carcinomatous meningitis):

Abstract

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Impact of gross total resection in patients with WHO grade III glioma harboring the IDH 1/2 mutation without the 1p/19q co-deletion

Impact of gross total resection in patients with WHO grade III glioma harboring the IDH ½ mutation without the 1p/19q co-deletion:

Abstract

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Utilization and impact of adjuvant therapy in anaplastic oligodendroglioma: an analysis on 1692 patients

Utilization and impact of adjuvant therapy in anaplastic oligodendroglioma: an analysis on 1692 patients:

Abstract

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Anaplastic astrocytoma: prognostic factors and survival in 4807 patients with emphasis on receipt and impact of adjuvant therapy

Anaplastic astrocytoma: prognostic factors and survival in 4807 patients with emphasis on receipt and impact of adjuvant therapy:

Abstract

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Composition chimique et activité antibactérienne de l’huile essentielle de Teucrium polium L. du mont de Tessala (Algérie occidentale)

Résumé

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Évaluation des propriétés antioxydantes, anti-inflammatoires et photoprotectrices des lipides de Lawsonia inermis

Résumé

Dans cette étude, nous nous sommes intéressés à évaluer les propriétés cosmétiques des lipides des feuilles de Lawsonia inermis. L'étude de l'activité photoprotectrice des lipides a été évaluée par le test d'absorbance en UV en utilisant le spectrophotomètre UV-visible. Nous avons montré que l'extrait lipidique et l'extrait d'acétate d'éthyle de Lawsonia inermis présentent une absorbance en UV qui est plus forte en UVB. L'effet antioxydant de l'extrait lipidique a été réalisé par le test utilisant le radical libre DPPH (2,2'-diphényl-1-picrylhydrazyle). Les résultats obtenus ont montré que l'extrait lipidique est doué d'activité antioxydante importante avec un IC50 de 0,019 mg/ml, comparé à 0,07 mg/ml pour le butylhydroxytoluène. L'activité anti-inflammatoire d'extrait lipidique de Lawsonia inermis a été évaluée chez les lapins par le test d'inflammation provoquée par injection de la carragénine. Les résultats ont révélé que l'extrait lipidique réduit l'inflammation de façon très significative, l'inhibition maximale de l'inflammation a atteint 90,30 % pour les lipides de Lawsonia inermis. Cette valeur a été supérieure à celle obtenue pour le diclofénac qui est de 78,5 %.

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Cystite et conseil officinal : intérêt d’un produit de phytothérapie associant des extraits de piloselle, de canneberge et d’orthosiphon

Résumé

La cystite est une inflammation de la vessie souvent provoquée par une infection et généralement traitée par antibiothérapie. Ses symptômes sont gênants et doivent être traités le plus précocement possible. Cette étude observationnelle réalisée en pharmacie a évalué l'intérêt d'un produit associant des extraits de piloselle (Hieracium pilosella L.), de canneberge (Vaccinium macrocarpon Aiton) et d'orthosiphon (Orthosiphon stamineus Benth synonyme d'Orthosiphon aristatus [Blume] Miq.) dans la prise en charge des symptômes de cystite. Au total, 65 questionnaires complétés par des femmes ayant pris le produit pendant trois jours en raison de symptômes évocateurs d'une cystite depuis moins de 48 heures ont été analysés. Après trois jours de prise (J4), une disparition totale de tous les symptômes (brûlures mictionnelles, envie fréquente d'uriner en quantité faible, urines troubles et/ou malodorantes et douleur dans le bas-ventre) a été observée chez 72 % (47/65) des femmes; quelques symptômes persistaient (à moindre score) chez 28 % (18/65) des participantes. Une diminution significative de 90 % du score global de l'intensité des symptômes a été observée entre J1 et J4 (p < 0,001). Le retentissement des symptômes sur la vie quotidienne des femmes était significativement moindre à J4. Ces résultats montrent l'intérêt d'une prise en charge des symptômes de cystite par l'association de piloselle, canneberge et orthosiphon. Cette association pourrait soulager efficacement les symptômes de cystite tout en préservant la flore commensale.

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Effet hypotenseur d’un extrait aqueux de Combretum micranthum G. Don (Combretaceae)

Résumé

L'analyse phytochimique de l'extrait aqueux de Combretum micranthum (COM) [Combretaceae], couramment utilisé par la population sous forme de décoction, révèle la présence de stérols et polyterpènes, de polyphénols, de saponosides, de flavonoïdes, de tanins catéchiques, de quinones et ainsi que d'alcaloïdes. La présence de tous ces composés chimiques pourrait être à l'origine des différentes vertus thérapeutiques attribuées à cette plante médicinale. L'étude toxicologique de COMa permis de déterminer par la méthode graphique de Miller et Tainter et par la méthode par calcul de Dragsted et Lang respectivement une dose létale 50 % égale à 1 258 ± 72,84 mg/kg de poids corporel et 1 500 ± 89,12 mg/ kg de PC. Ces valeurs indiquent que cet extrait aqueux d'origine naturelle est modérément toxique par voie intrapéritonéale. Aux doses comprises entre 1,66.10^–3 et 6.10^–1 g/kg de PC, cet extrait aqueux induit une hypotension soutenue, dose-dépendante semblable à celle induite par l'acétylcholine de 5,6.10^–7 à 5,5.10^–4 g/kg de PC. Il réduit fortement l'hypertension induite par l'adrénaline à 2,5.10^–5 g/kg de PC. Ces résultats indiquent que l'extrait aqueux de COM est un hypotenseur. Ils justifient l'utilisation traditionnelle de cette plante pour traiter l'hypertension artérielle. L'inhibition de l'effet hypotensif de COM par l'atropine, antagoniste compétitif des récepteurs cholinergiques de type muscarinique, suggère la présence dans cet extrait aqueux de principes actifs cholinomimétiques de type muscarinique.

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Euroasian Journal of Hepato-Gastroenterology

Table of Contents

1. EDITORIAL

Editorial

Rauf M Aghayev

v-vi

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2. ORIGINAL ARTICLE

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1-4

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3. ORIGINAL ARTICLE

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Madhusudan Saha, Irin Parveen, Bimal Chandra Shil, Shasanka Kumar Saha, Ranjit Kumar Banik, Monojit Majumder, Mahjuba Umme Salam, ASM Nazmul Islam

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4. ORIGINAL ARTICLE

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Forhad Hossain Md Shahed, Mamun-Al-Mahtab, Salimur Rahman

8-9

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5. ORIGINAL ARTICLE

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Md Nasirul Islam, Mobin Khan, Nooruddin Ahmad, Mamun-Al-Mahtab, Md Fazal Karim

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6. ORIGINAL ARTICLE

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Makoto Irie, Tetsuro Sohda, Akira Anan, Atsushi Fukunaga, Kazuhide Takata, Takashi Tanaka, Keiji Yokoyama, Daisuke Morihara, Yasuaki Takeyama, Satoshi Shakado, Shotaro Sakisaka

13-18

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10018-1159 |Free

7. RESEARCH ARTICLE

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Jorge Aguiar, Gerardo García, Yamila León, Eduardo Canales, José Angel Silva, Omar Gell, Regla Estrada, Ivis Morán, Verena Muzio, Gerardo Guillén, Eduardo Pentón, Julio Cesar Aguilar

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8. RESEARCH ARTICLE

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Freya M Freyre Almeida, Aracelys Blanco, Heidy Trujillo, Dunia Hernández, Daymir García, José S Alba, Matilde López Abad, Nelson Merino, Yadira Lobaina, Julio C Aguilar Rubido

25-30

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10018-1161 |Free

9. RESEARCH ARTICLE

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Necati Örmeci, Xheni Deda, Çagdas Kalkan, Ali Emrehan Tüzün, Fatih Albayrak, Abdulkadir Dökmeci, D Kadir Bahar, Hasan Özkan, Ramazan Idilman, Kubilay Çinar

31-34

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10. REVIEW ARTICLE

Tackling HCV-3 in Asia: Breakthroughs for Efficient and Cost-effective Treatment Strategies

Naba Saeed, Ahmet Gurakar

35-42

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11. MINI REVIEW

Past, Present, and Future of Viral Hepatitis in Bangladesh

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43-44

Full Text PDF | Abstract </ a> | 10.5005/jp-journals-10018-1164 |Free