For both men and women worldwide, colorectal cancer is among the leading causes of cancer-related death. This study aimed to assess the mortality trends of colorectal cancer in Serbia between 1991 and 2010, pr…
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Underwater sound of rigid-hulled inflatable boats was recorded 142 times in total, over 3 sites: 2 in southern British Columbia, Canada, and 1 off Western Australia. Underwater sound peaked between 70 and 400 Hz, exhibiting strong tones in this frequency range related to engine and propeller rotation. Sound propagation models were applied to compute monopole source levels, with the source assumed 1 m below the sea surface. Broadband source levels (10–48 000 Hz) increased from 134 to 171 dB re 1 μPa @ 1 m with speed from 3 to 16 m/s (10–56 km/h). Source power spectral density percentile levels and 1/3 octave band levels are given for use in predictive modeling of underwater sound of these boats as part of environmental impact assessments.
A stochastic model is presented for nanoparticle transport in a biofilm to explain how the combination of acoustic oscillations and intermittent retention due to interaction with the pore walls of the biofilm leads to diffusion enhancement. An expression for the effective diffusion coefficient was derived that varies with the square of the oscillation velocity amplitude. This expression was validated by comparison of an analytical diffusion solution to the stochastic model prediction. The stochastic model was applied to an example problem associated with liposome penetration into a hydrogel, and it was found to yield solutions in which liposome concentration varied exponentially with distance into the biofilm.
This study tested American preschoolers' ability to use phrasal prosody to constrain their syntactic analysis of locally ambiguous sentences containing noun/verb homophones (e.g., [The baby flies] [hide in the shadows] vs [The baby] [flies his kite], brackets indicate prosodic boundaries). The words following the homophone were masked, such that prosodic cues were the only disambiguating information. In an oral completion task, 4- to 5-year-olds successfully exploited the sentence's prosodic structure to assign the appropriate syntactic category to the target word, mirroring previous results in French (but challenging previous English-language results) and providing cross-linguistic evidence for the role of phrasal prosody in children's syntactic analysis.
The current investigation contributes to a perceptual similarity-based approach to dysarthria characterization by utilizing an innovative statistical approach, multinomial logistic regression with sparsity constraints, to identify acoustic features underlying each listener's impressions of speaker similarity. The data-driven approach also permitted an examination of the effect of clinical experience on listeners' impressions of similarity. Listeners, irrespective of level of clinical experience, were found to rely on similar acoustic features during the perceptual sorting task, known as free classification. Overall, the results support the continued advancement of a similarity-based approach to characterizing the communication disorders associated with dysarthria.
Audiology patient fall statistics and risk factors compared to non-audiology patients.
Int J Audiol. 2016 Jun 22;:1-7
Authors: Criter RE, Honaker JA
Abstract
OBJECTIVE: To compare fall statistics (e.g. incidence, prevalence), fall risks, and characteristics of patients who seek hearing healthcare from an audiologist to individuals who have not sought such services.
DESIGN: Case-control study.
STUDY SAMPLE: Two groups of community-dwelling older adult patients: 25 audiology patients aged 60 years or older (M age: 69.2 years, SD: 4.5, range: 61-77) and a control group (gender- and age-matched ±2 years) of 25 non-audiology patients (M age: 69.6, SD: 4.7, range: 60-77).
RESULTS: Annual incidence of falls (most recent 12 months) was higher in audiology patients (68.0%) than non-audiology patients (28.0%; p = .005). Audiology patients reported a higher incidence of multiple recent falls (p =.025) and more chronic health conditions (p = .028) than non-audiology patients.
CONCLUSIONS: Significantly more audiology patients fall on an annual basis than non-audiology patients, suggesting that falls are a pervasive issue in general hearing clinics. Further action on the part of healthcare professionals providing audiologic services may be necessary to identify individuals at risk for falling.
PMID: 27329486 [PubMed - as supplied by publisher]
Cochlear implantation: Optimizing outcomes through evidence-based clinical decisions.
Int J Audiol. 2016;55 Suppl 2:S1-2
Authors: Dowell R, Galvin K, Cowan R
PMID: 27329573 [PubMed - in process]
Hearing thresholds, tinnitus, and headphone listening habits in nine-year-old children.
Int J Audiol. 2016 Jun 22;:1-10
Authors: Båsjö S, Möller C, Widén S, Jutengren G, Kähäri K
Abstract
OBJECTIVE: Investigate hearing function and headphone listening habits in nine-year-old Swedish children.
DESIGN: A cross-sectional study was conducted and included otoscopy, tympanometry, pure-tone audiometry, and spontaneous otoacoustic emissions (SOAE). A questionnaire was used to evaluate headphone listening habits, tinnitus, and hyperacusis.
STUDY SAMPLE: A total of 415 children aged nine years.
RESULTS: The prevalence of a hearing threshold ≥20 dB HL at one or several frequencies was 53%, and the hearing thresholds at 6 and 8 kHz were higher than those at the low and mid frequencies. SOAEs were observed in 35% of the children, and the prevalence of tinnitus was 5.3%. No significant relationship between SOAE and tinnitus was found. Pure-tone audiometry showed poorer hearing thresholds in children with tinnitus and in children who regularly listened with headphones.
CONCLUSION: The present study of hearing, listening habits, and tinnitus in nine-year old children is, to our knowledge, the largest study so far. The main findings were that hearing thresholds in the right ear were poorer in children who used headphones than in children not using them, which could be interpreted as headphone listening may have negative consequences to children's hearing. Children with tinnitus showed poorer hearing thresholds compared to children without tinnitus.
PMID: 27329351 [PubMed - as supplied by publisher]
Audiology patient fall statistics and risk factors compared to non-audiology patients.
Int J Audiol. 2016 Jun 22;:1-7
Authors: Criter RE, Honaker JA
Abstract
OBJECTIVE: To compare fall statistics (e.g. incidence, prevalence), fall risks, and characteristics of patients who seek hearing healthcare from an audiologist to individuals who have not sought such services.
DESIGN: Case-control study.
STUDY SAMPLE: Two groups of community-dwelling older adult patients: 25 audiology patients aged 60 years or older (M age: 69.2 years, SD: 4.5, range: 61-77) and a control group (gender- and age-matched ±2 years) of 25 non-audiology patients (M age: 69.6, SD: 4.7, range: 60-77).
RESULTS: Annual incidence of falls (most recent 12 months) was higher in audiology patients (68.0%) than non-audiology patients (28.0%; p = .005). Audiology patients reported a higher incidence of multiple recent falls (p =.025) and more chronic health conditions (p = .028) than non-audiology patients.
CONCLUSIONS: Significantly more audiology patients fall on an annual basis than non-audiology patients, suggesting that falls are a pervasive issue in general hearing clinics. Further action on the part of healthcare professionals providing audiologic services may be necessary to identify individuals at risk for falling.
PMID: 27329486 [PubMed - as supplied by publisher]
Results using the OPAL strategy in Mandarin speaking cochlear implant recipients.
Int J Audiol. 2016 Jun 22;:1-12
Authors: Vandali AE, Dawson PW, Arora K
Abstract
OBJECTIVE: To evaluate the effectiveness of an experimental pitch-coding strategy for improving recognition of Mandarin lexical tone in cochlear implant (CI) recipients.
DESIGN: Adult CI recipients were tested on recognition of Mandarin tones in quiet and speech-shaped noise at a signal-to-noise ratio of +10 dB; Mandarin sentence speech-reception threshold (SRT) in speech-shaped noise; and pitch discrimination of synthetic complex-harmonic tones in quiet. Two versions of the experimental strategy were examined: (OPAL) linear (1:1) mapping of fundamental frequency (F0) to the coded modulation rate; and (OPAL+) transposed mapping of high F0s to a lower coded rate. Outcomes were compared to results using the clinical ACE™ strategy.
STUDY SAMPLE: Five Mandarin speaking users of Nucleus® cochlear implants.
RESULTS: A small but significant benefit in recognition of lexical tones was observed using OPAL compared to ACE in noise, but not in quiet, and not for OPAL+ compared to ACE or OPAL in quiet or noise. Sentence SRTs were significantly better using OPAL+ and comparable using OPAL to those using ACE. No differences in pitch discrimination thresholds were observed across strategies.
CONCLUSIONS: OPAL can provide benefits to Mandarin lexical tone recognition in moderately noisy conditions and preserve perception of Mandarin sentences in challenging noise conditions.
PMID: 27329178 [PubMed - as supplied by publisher]
Sudden sensorineural hearing loss with positional vertigo: Initial findings of positional nystagmus and hearing outcomes.
Int J Audiol. 2016 Jun 22;:1-6
Authors: Kim CH, Shin JE, Yang YS, Im D
Abstract
OBJECTIVES: To investigate the initial findings of positional nystagmus in patients with sudden sensorineural hearing loss (SSNHL) and positional vertigo, and to compare hearing improvement among patients with different types of positional nystagmus.
DESIGN: The characteristics of positional nystagmus upon initial examination were analysed, and the initial mean pure-tone audiometry (PTA) threshold was compared with that at three months after treatment.
STUDY SAMPLE: Forty-four SSNHL patients with concomitant positional vertigo were included.
RESULTS: Positional nystagmus was classified into five subgroups; persistent geotropic direction-changing positional nystagmus (DCPN) in head-roll test (HRT) and negative Dix-Hallpike test (DHT), persistent apogeotropic DCPN in HRT and negative DHT, positive DHT and negative HRT, persistent geotropic DCPN in HRT and positive DHT, and persistent apogeotropic DCPN in HRT and positive DHT. PTA threshold improvement was significantly greater in SSNHL patients with negative DHT than with positive DHT (p = 0.027).
CONCLUSIONS: When geotropic DCPN was elicited by HRT, the nystagmus was persistent, which suggests that alteration of specific gravity of the endolymph, rather than the lateral canal canalolithiasis, may be a cause of this characteristic positional nystagmus. Positive DTH may be a prognostic factor for worse hearing recovery among patients with SSNHL and positional vertigo.
PMID: 27329283 [PubMed - as supplied by publisher]
Cochlear implantation: Optimizing outcomes through evidence-based clinical decisions.
Int J Audiol. 2016;55 Suppl 2:S1-2
Authors: Dowell R, Galvin K, Cowan R
PMID: 27329573 [PubMed - in process]
Locally advanced non-small cell lung cancer (NSCLC) continues to be a challenging disease to treat. With high rates of both local and distant failures, there is significant interest in finding more biologicall…
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For both men and women worldwide, colorectal cancer is among the leading causes of cancer-related death. This study aimed to assess the mortality trends of colorectal cancer in Serbia between 1991 and 2010, pr…
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The post Behavioral and Psychological Symptoms and Caregiver Burden in Mexican Alzheimer's Disease Patients appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28REb3W via IFTTT περισσότερα » The Havoc of a Giant Spleen sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
The post The Havoc of a Giant Spleen appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28NGUaO via IFTTT περισσότερα » Economic Approaches to Understanding Change in Happiness sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Are people condemned to an inherent level of experienced happiness? A review of the economic research on subjective well-being gives reason to the assessment that happiness can change. First, empirical findings clearly indicate that people are not indifferent to adverse living conditions when reporting their subjective well-being as observed for limited freedom of choice, low […] περισσότερα » Proteomic analysis of docetaxel resistance in human nasopharyngeal carcinoma cells using the two-dimensional gel electrophoresis method. sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months. Two-dimensional gel electrophoresis and ESI-Q-TOF-MS were used to compare the differential expression of docetaxel-resistance-associated […] περισσότερα » Paralleled comparison of vectors for the generation of CAR-T cells. sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into […] περισσότερα » Flipping a Dental Anatomy Course: A Retrospective Study Over Four Years sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Flipped classrooms have been successfully used to increase student engagement and support student learning in a range of educational fields, including health education. These advantages for student learning supported implementation of the flipped classroom in introductory sciences and preclinical courses in dental education. We report on a 4-year retrospective study which compared two methods of […] περισσότερα » Experimental Study on Detection of Deterioration in Concrete Using Infrared Thermography Technique sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Concrete is certainly prone to internal deteriorations or defects during the construction and operating periods. Compared with other nondestructive techniques, infrared thermography can easily detect the subsurface delamination in a very short period of time, but accurately identifying its size and depth in concrete is a very challenging task. In this study, experimental testing was […] περισσότερα » Quiz: 5 common summer injuries and how to prevent and treat them – KSL.com sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Quiz: 5 common summer injuries and how to prevent and treat them KSL.com If you find yourself paying the price of some summer sun-worshipping, The Skin Cancer Foundation recommends cooling your skin down as soon as possible, moisturizing the skin while damp, take or use an anti-inflammatory medication like ibuprofen or … and more » […] περισσότερα » A Decade of Becoming — Saying Goodbye To My Thirties – Huffington Post sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Huffington Post A Decade of Becoming — Saying Goodbye To My Thirties Huffington Post At 31 and at 34 I've lost two very important people in my life to cancer. After burying my head in the sand for long … I've stopped making excuses at 36 and started writing in a language that wasn't my […] περισσότερα » No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Abstract In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph-angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two-stage analysis: First, 381 polymorphisms from 30 genes (eight Vascular Endothelial Growth Factor (VEGF) and 22 Matrix Metalloproteinase [MMP] genes) […] περισσότερα » Effect of Toothbrushing Frequency on Incidence and Increment of Dental Caries: A Systematic Review and Meta-Analysis Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Toothbrushing is considered fundamental self-care behavior for maintenance of oral health, and brushing twice a day has become a social norm, but the evidence base for this frequency is weak. This systematic review and meta-analysis aims to assess the effect of toothbrushing frequency on the incidence and increment of carious lesions. Medline, Embase, Cinahl, and Cochrane databases were searched. Screening and quality assessment were performed by 2 independent reviewers. Three different meta-analyses were conducted: 2 based on the caries outcome reported in the studies (incidence … περισσότερα » Patient-related outcome measures with implant therapy after 5 years Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objective To analyze patients' perception of implant therapy in partial edentulism, after 5 years with implant-supported reconstructions. Material and methods Patients who received dental implants at the National Dental Centre, Singapore 3–9 years earlier (mean: 5.2 years) were invited to participate in the study. Responders were examined clinically, and asked to answer a questionnaire with 13 statements. Results Of the 880 patients, 206 patients, with 329 implants, agreed to participate. Of the implants, 82% supported single crowns, while 18% were reconstructed with splin… περισσότερα » Five-year retrospective study on success, survival and incidence of complications of single crowns supported by dental implants Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objective To determine the survival and the incidence of biologic and technical complications of implant-supported single crowns after 5 years of function. Material and methods Patients treated with dental implants at the National Dental Centre, Singapore, from 2006 to 2010 were recruited from the Implant Registry and evaluated by two clinicians. One hundred and ninety-four patients, with 266 implant single crowns (SCs), were examined clinically for biologic and technical parameters. Digital radiographs were also obtained. Failure and complication rates were calculated base… περισσότερα » Radiographic and histological evaluation of deproteinized bovine bone mineral vs. deproteinized bovine bone mineral with 10% collagen in ridge preservation. A randomized controlled clinical trial Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objectives The aims of this randomized clinical trial were to compare the dimensional changes and the histological composition after using deproteinized bovine bone mineral (DBBM) or deproteinized bovine bone mineral with 10% collagen (DBBM-C) and a collagen membrane in ridge preservation procedures. Material and methods Patients who required an extraction and a subsequent implant-supported rehabilitation at a non-molar site were recruited. After extraction, a cone beam computed tomography (CBCT) was performed and sites were randomly treated either with DBBM or DBBM-C plus … περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα *Background:* Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. *Methods:* Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated… περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα *Background:* Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. *Methods:* Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated… περισσότερα » Mentoring Early-Career Faculty Researchers Is Important-But First «Train the Trainer». medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
It has long been known that mentoring is critical to the success of junior faculty researchers. The controlled intervention study by Libby et al published in this issue of Academic Medicine demonstrates that institutional investment in a mentored research career development program for early-career faculty investigators provided significant long-term gains in grant productivity. Academic institutions […] περισσότερα » The Teachers of Quality Academy: A Learning Community Approach to Preparing Faculty to Teach Health Systems Science. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Problem: Although efforts to integrate health systems science (HSS) topics, such as patient safety, quality improvement (QI), interprofessionalism, and population health, into health professions curricula are increasing, the rate of change has been slow. Approach: The Teachers of Quality Academy (TQA), Brody School of Medicine at East Carolina University, was established in January 2014 with […] περισσότερα » Targeting TOPK in ovarian cancer medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Background; We aimed to clarify the clinical significance of TOPK (T-lymphokine-activated killer cell-originated protein kinase) expression in ovarian cancer and evaluate the possible effect of TOPK inhibitors, OTS514 and OTS964, on ovarian cancer cells. Methods; TOPK expression was examined by immunohistochemistry using 163 samples with epithelial ovarian cancer (EOC). TOPK protein level and FOXM1 transcriptional […] περισσότερα » Genomic alterations in salivary adenocarcinoma medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Purpose: We sought to identify genomic alterations (GAs) in salivary gland adenocarcinomas, not otherwise specified (NOS), salivary duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca ex PA), and salivary carcinoma, NOS. Experimental design: DNA was extracted from 149 tumors. Comprehensive genomic profiling (CGP) was performed on hybridization-captured adaptor ligation-based libraries of 182 or 315 cancer-related […] περισσότερα » Mutational analysis of cfDNA and single CTCs in MBC medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Purpose: The purpose of this study was to directly compare mutation profiles in multiple single CTCs and cfDNA isolated from the same blood samples taken from patients with metastaic breast cancer (MBC). We aimed to determine whether cell-free DNA would reflect the heterogeneity observed in 40 single CTCs. Experimental design: CTCs were enumerated by Cellsearch. […] περισσότερα » Tumor Microenvironment in Gene Expression Signatures medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
The tumor microenvironment contributes important information in gene expression signatures but may be susceptible to sampling variance. Mesenchymal signatures in particular may be influenced by sampling of non-representative regions with high stromal content. Appropriate pathology quality control is required to ensure reproducibility of gene expression signatures. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Pgw0K via IFTTT […] περισσότερα » CSF-1R and NLC in CLL medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Purpose:Monocytes and their progeny are abundant constituents of the tumor microenvironment in lymphoproliferative disorders, including chronic lymphocytic leukemia (CLL). Monocyte-derived cells, including nurse-like cells (NLC) in CLL, promote lymphocyte proliferation and survival, confer resistance to chemotherapy, and are associated with more rapid disease progression. Colony-stimulating factor-1 receptor (CSF-1R) regulates the homeostatic survival of tissue-resident macrophages. […] περισσότερα » Past participle formation in specific language impairment. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
CONCLUSIONS & IMPLICATIONS: In contrast to earlier findings, the present results demonstrate that regular participle formation is problematic for German children with SLI. PMID: 27321811 [PubMed – as supplied by publisher] (Source: International Journal of Language and Communication Disorders) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28NGaCL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete […] περισσότερα » Oxford Handbook of Anaesthesia, 4th ed. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
No abstract available from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Rykvb via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα » The Biomechanical Effects of Resuscitation Colloids on the Compromised Lung Endothelial Glycocalyx. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
BACKGROUND: The endothelial glycocalyx is an important component of the vascular permeability barrier, forming a scaffold that allows serum proteins to create a gel-like layer on the endothelial surface and transmitting mechanosensing and mechanotransduction information that influences permeability. During acute inflammation, the glycocalyx is degraded, changing how it interacts with serum proteins and colloids used […] περισσότερα » First case of Currarino Syndrome and Trimethylaminuria: two rare diseases for a complex clinical presentation otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/28X47ao via IFTTT http://ift.tt/28RoF7N περισσότερα » First case of Currarino Syndrome and Trimethylaminuria: two rare diseases for a complex clinical presentation Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/28X47ao via IFTTT περισσότερα » No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph-angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two-stage analysis: First, 381 polymorphisms from 30 genes (eight Vascular Endothelial Growth Factor (VEGF) and 22 Matrix Metalloproteinase [MMP] genes) […] περισσότερα » Genetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract RAD51B plays a central role in homologous recombinational repair (HRR) of DNA double-strand breaks (DSBs), which is important to prevent genomic instability, a hallmark of cancer. Recent studies suggested that common genetic variants of RAD51B may contribute to cancer susceptibility. In this study, we aimed to investigate whether potentially functional variants within miRNA-binding sites […] περισσότερα » Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract The carboxyl terminus of the Hsc70-interacting protein (CHIP) is considered to induce the ubiquitination and degradation of several oncogenic proteins, and play a role in the inhibition of tumor progression and invasion under experimental conditions. However, the impact of CHIP expression on the prognosis of breast cancer patients has not yet been established. In […] περισσότερα » Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain […] περισσότερα » RRM1 *151A>T, RRM1 -756T>C, and RRM1 -585T>Gis associated with increased susceptibility of lung cancer in Chinese patients alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract Ribonucleotide reductase M1 (RRM1) is a crucial gene in DNA repair. Recent studies have shown that RRM1 expression can be a powerful predictor of survival or chemotherapy sensitivity in patients presenting with carcinomas who are treated with adjuvant gemcitabine-based chemotherapy including lung cancer. However, the relationship between the single nucleotide polymorphisms (SNP) of RRM1 […] περισσότερα » TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract Transforming acidic coiled-coil protein 2 (TACC2) belongs to TACC family proteins and involved in a variety of cellular processes through interactions with some molecules involved in centrosomes/microtubules dynamics. Mounting evidence suggests that TACCs is implicated in the progression of some human malignancies, but significance of TACC2 protein in breast carcinoma is still unknown. Therefore, […] περισσότερα » Closer adherence to cancer prevention recommendations more effective alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
As part of their cancer prevention efforts, leading cancer organisations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) have published recommendations on diet and physical… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/28OUZUe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we […] περισσότερα » Patient-related outcome measures with implant therapy after 5 years alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract Objective To analyze patients' perception of implant therapy in partial edentulism, after 5 years with implant-supported reconstructions. Material and methods Patients who received dental implants at the National Dental Centre, Singapore 3–9 years earlier (mean: 5.2 years) were invited to participate in the study. Responders were examined clinically, and asked to answer a questionnaire […] περισσότερα » Five-year retrospective study on success, survival and incidence of complications of single crowns supported by dental implants alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract Objective To determine the survival and the incidence of biologic and technical complications of implant-supported single crowns after 5 years of function. Material and methods Patients treated with dental implants at the National Dental Centre, Singapore, from 2006 to 2010 were recruited from the Implant Registry and evaluated by two clinicians. One hundred and […] περισσότερα » Anatomy Pathology Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Anatomy Pathology via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your compu… περισσότερα » Surgical and Radiologic Anatomy Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Surgical and Radiologic Anatomy *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your c… περισσότερα » Indian Journal of Radiology and Imaging Alexandros G. SfakianakisστοΑπεικονιστικήΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Indian Journal of Radiology and Imaging : 2016 - 26(2) *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to yo… περισσότερα » Nanomaterials, Vol. 6, Pages 122: Plasma Nanoengineering and Nanofabrication Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα With the recent advances in nanotechnology, plasma nanofabrication has become an exciting new niche because plasma-based approaches can deliver unique structures at the nanoscale that cannot be achieved by other techniques and/or in a more economical and environmentally friendly manner.[…] from #Medicine via ola Kala on Inoreader http://ift.tt/28RzmYq via IFTTT περισσότερα » Highly educated men are more likely to be diagnosed with a brain tumour Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα A new study from Karolinska Institutet published in The Journal of Epidemiology and Community Health shows that people of a higher socioeconomic position are more commonly diagnosed with glioma, the most common form of adult brain tumour. The results are particularly salient for men. The paper is based on a large population study including 4.3 million people born in Sweden between 1911 and 1961 who studied during the period from 1993 to 2010. The results show a correlation between socioeconomic position and the likelihood of being diagnosed with glioma that although found in both … περισσότερα » Returning to KI with the bigger picture Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα During his postdoc period at Harvard University, Ninib Baryawno has learnt to think big, and when he returns to KI next year, he'll be bringing with him a broader view of research. It might sound mad for someone to switch to another research field when about to do their postdoc period overseas. For Ninib Baryawno, however, it was a deliberate choice. As a doctoral student, he studied medulloblastoma, a form of cancer that creates brain tumours in children and that scientists now believe to be a stem cell disease. Ninib knew even then that he wanted to learn more about stem cells, a… περισσότερα » Low-Cost Simulation to Teach Anesthetists' Non-Technical Skills in Rwanda. AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα BACKGROUND: Safe anesthesia care is challenging in developing countries where there are shortages of personnel, drugs, equipment, and training. Anesthetists' Non-technical Skills (ANTS)-task management, team working, situation awareness, and decision making-are difficult to practice well in this context. Cesarean delivery is the most common surgical procedure in sub-Saharan Africa. This pilot study investigates whether a low-cost simulation model, with good psychological fidelity, can be used effectively to teach ANTS during cesarean delivery in Rwanda. METHODS: Study participants w… περισσότερα » Impact of On-Bypass Red Blood Cell Transfusion on Severe Postoperative Morbidity or Mortality in Children. AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα BACKGROUND: Children undergoing cardiac surgery are frequently exposed to red blood cell (RBC) transfusions mainly in the case of hemorrhage or low oxygen transport. However, in this population, RBCs are sometimes added to the cardiopulmonary bypass (CPB) priming solution to maintain a predefined hematocrit on bypass. In this study, we investigated the impact of RBCs added to the CPB on severe postoperative morbidity or mortality. METHODS: This retrospective cohort study was conducted between 2006 and 2012 in a tertiary care level, children's hospital. Children receiving red cells on… περισσότερα » Impact of On-Bypass Red Blood Cell Transfusion on Severe Postoperative Morbidity or Mortality in Children. Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα BACKGROUND: Children undergoing cardiac surgery are frequently exposed to red blood cell (RBC) transfusions mainly in the case of hemorrhage or low oxygen transport. However, in this population, RBCs are sometimes added to the cardiopulmonary bypass (CPB) priming solution to maintain a predefined hematocrit on bypass. In this study, we investigated the impact of RBCs added to the CPB on severe postoperative morbidity or mortality. METHODS: This retrospective cohort study was conducted between 2006 and 2012 in a tertiary care level, children's hospital. Children receiving red cells on… περισσότερα » TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Abstract Transforming acidic coiled-coil protein 2 (TACC2) belongs to TACC family proteins and involved in a variety of cellular processes through interactions with some molecules involved in centrosomes/microtubules dynamics. Mounting evidence suggests that TACCs is implicated in the progression of some human malignancies, but significance of TACC2 protein in breast carcinoma is still unknown. Therefore, […] περισσότερα » Closer adherence to cancer prevention recommendations more effective sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
As part of their cancer prevention efforts, leading cancer organisations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) have published recommendations on diet and physical… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28OUZUe via IFTTT περισσότερα » What Explains Differences in Availability of Community Health-Related Services for Seniors in the United States? sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Objective: This study analyzes the links between planning, the built environment, and availability of health-related community services across U.S. urban and rural communities. Method: We analyze the first national survey of health-related community services for seniors (2010 Maturing of America), covering 1,459 U.S. cities and counties. We tested the influence of morbidity (diabetes and obesity), […] περισσότερα » Off-label and unlicensed medicines to hospitalised children in Norway Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives The aim of this study was to investigate the use of off-label (OL) and unlicensed (UL) medicines to hospitalised children in Norway, to add to the current knowledge on use of medicines in this vulnerable patient group. Methods The study was performed as a cross-sectional prospective study. Medication was classified as on- or off-label based on the comparison with the SmPC regarding age, indication, dosage, route of administration and handling of the product. UL products were classified as imported or pharmacy produced. Key findings More than 90% of children r… περισσότερα » Safe implementation of standard concentration infusions in paediatric intensive care Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objective To evaluate safety, following introduction of standard concentrations of morphine infusions in paediatric critical care. Methods *Implementation*: A multidisciplinary team was convened, and several workstreams designated, including derivation of concentrations, manufacturing, supply, prescribing, administration using smart pump technology, training and evaluation. *Safety Evaluation*: Retrieval of all existing data on medication errors linked to morphine use using our hospital incident reporting system and risk assessment of errors in relation to standard conc… περισσότερα » Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives To investigate the apoptosis-inducing effect and underlying mechanisms of luteolin in cholangiocarcinoma (CCA) cells. Methods Cell viability was determined by sulphorhodamine B. Apoptosis was detected using acridine orange/ethidium bromide dye staining and annexin V/PI staining followed by flow cytometry. The effect of luteolin on the oxidative status of CCA cells was evaluated by measuring intracellular reactive oxygen species (ROS) levels using the dihydroethidium method and quantifying glutathione levels. The mitochondria transmembrane potential (ΔΨm) was … περισσότερα » Synergistic analgesic effect of propofol–alfentanil combination through detecting the inhibition of cAMP signal pathway Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objective The study aims to investigate the possible mechanism of the synergistic analgesic effect of propofol–alfentanil combination. Methods The synergistic analgesic effects of propofol–alfentanil combination in Sprague–Dawley (SD) rats were analysed through the von Frey test. Then, we examined the activity of phospholipase C (PLC) and the intracellular levels of Ca2+ and adenosine 3′, 5′cyclic monophosphate (cAMP) in primary neuronal cells of fetal SD rats. We detected the intracellular Ca2+ concentration by fluorescence and flow cytometry. The PLC activity of the pr… περισσότερα » Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives Carvacrol, a monoterpene widely present in nature, is commonly used in the food industry and in cosmetics, besides to possess a plethora of pharmacological properties, among these also *in vitro* vasorelaxing effects and *in vivo* hypotensive responses. Although in rat aortic rings carvacrol evoked a vasodilatation both in the presence and in the absence of endothelium, in preparations with intact endothelial layer its vasoactive response markedly improved. Methods This study aimed at investigating the mechanism of action responsible for the endothelial compo… περισσότερα » Thyroid Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* thyroid2 via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and … περισσότερα » Cephalalgia Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cephalalgia RSS feed – Preview Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer an… περισσότερα » Thyroid Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* thyroid via Alexandros G.Sfakianakis on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your co… περισσότερα » Spine Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Spine via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can… περισσότερα » Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic post-traumatic neuropathic pain in the ankle and foot: the PREPLANS study Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 2 ώρες Introduction Peripheral neuropathic pain (PNP) associated with trauma is often refractory to treatment. Administration of local anaesthetics (LA) and steroids around injured nerves has been proposed as an option for patients unresponsive to conventional treatments for refractory PNP following trauma. There is insufficient evidence to support a large, potentially expensive, full-scale randomised controlled trial (RCT) that involves comparison of effects of perineural steroids and LA against LA or saline injections on analgesia, physical and psychological functioning, and quality … περισσότερα » What Explains Differences in Availability of Community Health-Related Services for Seniors in the United States? medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Objective: This study analyzes the links between planning, the built environment, and availability of health-related community services across U.S. urban and rural communities. Method: We analyze the first national survey of health-related community services for seniors (2010 Maturing of America), covering 1,459 U.S. cities and counties. We tested the influence of morbidity (diabetes and obesity), […] περισσότερα » Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Uptake and integration of exogenous DNA into the bacterial genome play an important role in the evolution of the pathogen Helicobacter pylori . Here, the authors describe a bimodal pattern of chromosomal integration and show how restriction-modification systems limit the import of heterologous DNA. Nature Communications doi: 10.1038/ncomms11995 Authors: Sebastian Bubendorfer, Juliane Krebes, Ines […] περισσότερα » ASC filament formation serves as a signal amplification mechanism for inflammasomes medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome regulatory pathways. Nature Communications doi: 10.1038/ncomms11929 Authors: Mathias S. Dick, Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller, Petr Broz from #Medicine-SfakianakisAlexandros […] περισσότερα » Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal amplifications as a driving force in progression. Nature Communications doi: 10.1038/ncomms12008 Authors: Peter Ulz, Jelena Belic, […] περισσότερα » Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling. Nature Communications doi: 10.1038/ncomms12047 Authors: Fatemeh Mirzamohammadi, Garyfallia […] περισσότερα » The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article The activation of bacterial mechanosensitive channels is still not fully understood. Here, Bavi et al . show that the N-terminal helix of MscL dynamically couples membrane tension to channel gating, suggesting a conserved mechanism underlying the mechanosensitivity of ion channels of higher organisms. Nature Communications doi: 10.1038/ncomms11984 Authors: Navid Bavi, D. Marien Cortes, Charles […] περισσότερα » Experimental demonstration of the microscopic origin of circular dichroism in two-dimensional metamaterials medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article The effect of Ohmic dissipation in two-dimensional chiral materials has never been experimentally verified. Here, Khanikaev et al . demonstrate that the circular dichroism in a nanostructured metasurface occurs due to handedness-dependent Ohmic heating. Nature Communications doi: 10.1038/ncomms12045 Authors: A. B. Khanikaev, N. Arju, Z. Fan, D. Purtseladze, F. Lu, J. Lee, P. Sarriugarte, […] περισσότερα » Demographic routes to variability and regulation in bird populations medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Why does population variability differ? Sæther et al . show that the magnitude of temporal variation of avian population fluctuations is mainly determined by environmental fluctuations affecting recruitment, whereas regulation of mean population size occurs through density-dependent mortality. Nature Communications doi: 10.1038/ncomms12001 Authors: Bernt-Erik Sæther, Vidar Grøtan, Steinar Engen, Tim Coulson, Peter R. Grant, […] περισσότερα » Influence of orbital symmetry on diffraction imaging with rescattering electron wave packets medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Laser-induced electron diffraction possesses sufficient resolution to resolve nuclear dynamics in molecules, but imaging was thought to depend on the orbital symmetries for the backscattering electrons. Here, the authors image the structure of randomly oriented O 2 and C 2 H 2 molecules and prove the contrary. Nature Communications doi: 10.1038/ncomms11922 Authors: M. G. […] περισσότερα » The biogeography of red snow microbiomes and their role in melting arctic glaciers medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article The Arctic is melting at an unprecedented rate and key drivers are changes in snow and ice albedo. Here, the authors show that red pigmented snow algae play a crucial role in decreasing surface albedo and their patterns for diversity, pigmentation, and consequently albedo, are ubiquitous across the Arctic. Nature Communications doi: 10.1038/ncomms11968 Authors: […]The post Behavioral and Psychological Symptoms and Caregiver Burden in Mexican Alzheimer's Disease Patients appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28REb3W via IFTTT περισσότερα » The Havoc of a Giant Spleen sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα The post The Havoc of a Giant Spleen appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28NGUaO via IFTTT περισσότερα » Economic Approaches to Understanding Change in Happiness sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Are people condemned to an inherent level of experienced happiness? A review of the economic research on subjective well-being gives reason to the assessment that happiness can change. First, empirical findings clearly indicate that people are not indifferent to adverse living conditions when reporting their subjective well-being as observed for limited freedom of choice, low […] περισσότερα » Proteomic analysis of docetaxel resistance in human nasopharyngeal carcinoma cells using the two-dimensional gel electrophoresis method. sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months. Two-dimensional gel electrophoresis and ESI-Q-TOF-MS were used to compare the differential expression of docetaxel-resistance-associated […] περισσότερα » Paralleled comparison of vectors for the generation of CAR-T cells. sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into […] περισσότερα » Flipping a Dental Anatomy Course: A Retrospective Study Over Four Years sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Flipped classrooms have been successfully used to increase student engagement and support student learning in a range of educational fields, including health education. These advantages for student learning supported implementation of the flipped classroom in introductory sciences and preclinical courses in dental education. We report on a 4-year retrospective study which compared two methods of […] περισσότερα » Experimental Study on Detection of Deterioration in Concrete Using Infrared Thermography Technique sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Concrete is certainly prone to internal deteriorations or defects during the construction and operating periods. Compared with other nondestructive techniques, infrared thermography can easily detect the subsurface delamination in a very short period of time, but accurately identifying its size and depth in concrete is a very challenging task. In this study, experimental testing was […] περισσότερα » Quiz: 5 common summer injuries and how to prevent and treat them – KSL.com sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Quiz: 5 common summer injuries and how to prevent and treat them KSL.com If you find yourself paying the price of some summer sun-worshipping, The Skin Cancer Foundation recommends cooling your skin down as soon as possible, moisturizing the skin while damp, take or use an anti-inflammatory medication like ibuprofen or … and more » […] περισσότερα » A Decade of Becoming — Saying Goodbye To My Thirties – Huffington Post sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Huffington Post A Decade of Becoming — Saying Goodbye To My Thirties Huffington Post At 31 and at 34 I've lost two very important people in my life to cancer. After burying my head in the sand for long … I've stopped making excuses at 36 and started writing in a language that wasn't my […] περισσότερα » No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Abstract In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph-angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two-stage analysis: First, 381 polymorphisms from 30 genes (eight Vascular Endothelial Growth Factor (VEGF) and 22 Matrix Metalloproteinase [MMP] genes) […] περισσότερα » Effect of Toothbrushing Frequency on Incidence and Increment of Dental Caries: A Systematic Review and Meta-Analysis Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Toothbrushing is considered fundamental self-care behavior for maintenance of oral health, and brushing twice a day has become a social norm, but the evidence base for this frequency is weak. This systematic review and meta-analysis aims to assess the effect of toothbrushing frequency on the incidence and increment of carious lesions. Medline, Embase, Cinahl, and Cochrane databases were searched. Screening and quality assessment were performed by 2 independent reviewers. Three different meta-analyses were conducted: 2 based on the caries outcome reported in the studies (incidence … περισσότερα » Patient-related outcome measures with implant therapy after 5 years Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objective To analyze patients' perception of implant therapy in partial edentulism, after 5 years with implant-supported reconstructions. Material and methods Patients who received dental implants at the National Dental Centre, Singapore 3–9 years earlier (mean: 5.2 years) were invited to participate in the study. Responders were examined clinically, and asked to answer a questionnaire with 13 statements. Results Of the 880 patients, 206 patients, with 329 implants, agreed to participate. Of the implants, 82% supported single crowns, while 18% were reconstructed with splin… περισσότερα » Five-year retrospective study on success, survival and incidence of complications of single crowns supported by dental implants Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objective To determine the survival and the incidence of biologic and technical complications of implant-supported single crowns after 5 years of function. Material and methods Patients treated with dental implants at the National Dental Centre, Singapore, from 2006 to 2010 were recruited from the Implant Registry and evaluated by two clinicians. One hundred and ninety-four patients, with 266 implant single crowns (SCs), were examined clinically for biologic and technical parameters. Digital radiographs were also obtained. Failure and complication rates were calculated base… περισσότερα » Radiographic and histological evaluation of deproteinized bovine bone mineral vs. deproteinized bovine bone mineral with 10% collagen in ridge preservation. A randomized controlled clinical trial Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objectives The aims of this randomized clinical trial were to compare the dimensional changes and the histological composition after using deproteinized bovine bone mineral (DBBM) or deproteinized bovine bone mineral with 10% collagen (DBBM-C) and a collagen membrane in ridge preservation procedures. Material and methods Patients who required an extraction and a subsequent implant-supported rehabilitation at a non-molar site were recruited. After extraction, a cone beam computed tomography (CBCT) was performed and sites were randomly treated either with DBBM or DBBM-C plus … περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα *Background:* Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. *Methods:* Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated… περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα *Background:* Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. *Methods:* Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated… περισσότερα » Mentoring Early-Career Faculty Researchers Is Important-But First «Train the Trainer». medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα It has long been known that mentoring is critical to the success of junior faculty researchers. The controlled intervention study by Libby et al published in this issue of Academic Medicine demonstrates that institutional investment in a mentored research career development program for early-career faculty investigators provided significant long-term gains in grant productivity. Academic institutions […] περισσότερα » The Teachers of Quality Academy: A Learning Community Approach to Preparing Faculty to Teach Health Systems Science. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Problem: Although efforts to integrate health systems science (HSS) topics, such as patient safety, quality improvement (QI), interprofessionalism, and population health, into health professions curricula are increasing, the rate of change has been slow. Approach: The Teachers of Quality Academy (TQA), Brody School of Medicine at East Carolina University, was established in January 2014 with […] περισσότερα » Targeting TOPK in ovarian cancer medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Background; We aimed to clarify the clinical significance of TOPK (T-lymphokine-activated killer cell-originated protein kinase) expression in ovarian cancer and evaluate the possible effect of TOPK inhibitors, OTS514 and OTS964, on ovarian cancer cells. Methods; TOPK expression was examined by immunohistochemistry using 163 samples with epithelial ovarian cancer (EOC). TOPK protein level and FOXM1 transcriptional […] περισσότερα » Genomic alterations in salivary adenocarcinoma medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Purpose: We sought to identify genomic alterations (GAs) in salivary gland adenocarcinomas, not otherwise specified (NOS), salivary duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca ex PA), and salivary carcinoma, NOS. Experimental design: DNA was extracted from 149 tumors. Comprehensive genomic profiling (CGP) was performed on hybridization-captured adaptor ligation-based libraries of 182 or 315 cancer-related […] περισσότερα » Mutational analysis of cfDNA and single CTCs in MBC medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Purpose: The purpose of this study was to directly compare mutation profiles in multiple single CTCs and cfDNA isolated from the same blood samples taken from patients with metastaic breast cancer (MBC). We aimed to determine whether cell-free DNA would reflect the heterogeneity observed in 40 single CTCs. Experimental design: CTCs were enumerated by Cellsearch. […] περισσότερα » Tumor Microenvironment in Gene Expression Signatures medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα The tumor microenvironment contributes important information in gene expression signatures but may be susceptible to sampling variance. Mesenchymal signatures in particular may be influenced by sampling of non-representative regions with high stromal content. Appropriate pathology quality control is required to ensure reproducibility of gene expression signatures. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Pgw0K via IFTTT […] περισσότερα » CSF-1R and NLC in CLL medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Purpose:Monocytes and their progeny are abundant constituents of the tumor microenvironment in lymphoproliferative disorders, including chronic lymphocytic leukemia (CLL). Monocyte-derived cells, including nurse-like cells (NLC) in CLL, promote lymphocyte proliferation and survival, confer resistance to chemotherapy, and are associated with more rapid disease progression. Colony-stimulating factor-1 receptor (CSF-1R) regulates the homeostatic survival of tissue-resident macrophages. […] περισσότερα » Past participle formation in specific language impairment. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα CONCLUSIONS & IMPLICATIONS: In contrast to earlier findings, the present results demonstrate that regular participle formation is problematic for German children with SLI. PMID: 27321811 [PubMed – as supplied by publisher] (Source: International Journal of Language and Communication Disorders) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28NGaCL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete […] περισσότερα » Oxford Handbook of Anaesthesia, 4th ed. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα No abstract available from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Rykvb via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα » The Biomechanical Effects of Resuscitation Colloids on the Compromised Lung Endothelial Glycocalyx. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα BACKGROUND: The endothelial glycocalyx is an important component of the vascular permeability barrier, forming a scaffold that allows serum proteins to create a gel-like layer on the endothelial surface and transmitting mechanosensing and mechanotransduction information that influences permeability. During acute inflammation, the glycocalyx is degraded, changing how it interacts with serum proteins and colloids used […] περισσότερα » First case of Currarino Syndrome and Trimethylaminuria: two rare diseases for a complex clinical presentation otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/28X47ao via IFTTT http://ift.tt/28RoF7N περισσότερα » First case of Currarino Syndrome and Trimethylaminuria: two rare diseases for a complex clinical presentation Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/28X47ao via IFTTT περισσότερα » No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph-angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two-stage analysis: First, 381 polymorphisms from 30 genes (eight Vascular Endothelial Growth Factor (VEGF) and 22 Matrix Metalloproteinase [MMP] genes) […] περισσότερα » Genetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract RAD51B plays a central role in homologous recombinational repair (HRR) of DNA double-strand breaks (DSBs), which is important to prevent genomic instability, a hallmark of cancer. Recent studies suggested that common genetic variants of RAD51B may contribute to cancer susceptibility. In this study, we aimed to investigate whether potentially functional variants within miRNA-binding sites […] περισσότερα » Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract The carboxyl terminus of the Hsc70-interacting protein (CHIP) is considered to induce the ubiquitination and degradation of several oncogenic proteins, and play a role in the inhibition of tumor progression and invasion under experimental conditions. However, the impact of CHIP expression on the prognosis of breast cancer patients has not yet been established. In […] περισσότερα » Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain […] περισσότερα » RRM1 *151A>T, RRM1 -756T>C, and RRM1 -585T>Gis associated with increased susceptibility of lung cancer in Chinese patients alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract Ribonucleotide reductase M1 (RRM1) is a crucial gene in DNA repair. Recent studies have shown that RRM1 expression can be a powerful predictor of survival or chemotherapy sensitivity in patients presenting with carcinomas who are treated with adjuvant gemcitabine-based chemotherapy including lung cancer. However, the relationship between the single nucleotide polymorphisms (SNP) of RRM1 […] περισσότερα » TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract Transforming acidic coiled-coil protein 2 (TACC2) belongs to TACC family proteins and involved in a variety of cellular processes through interactions with some molecules involved in centrosomes/microtubules dynamics. Mounting evidence suggests that TACCs is implicated in the progression of some human malignancies, but significance of TACC2 protein in breast carcinoma is still unknown. Therefore, […] περισσότερα » Closer adherence to cancer prevention recommendations more effective alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα As part of their cancer prevention efforts, leading cancer organisations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) have published recommendations on diet and physical… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/28OUZUe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we […] περισσότερα » Patient-related outcome measures with implant therapy after 5 years alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract Objective To analyze patients' perception of implant therapy in partial edentulism, after 5 years with implant-supported reconstructions. Material and methods Patients who received dental implants at the National Dental Centre, Singapore 3–9 years earlier (mean: 5.2 years) were invited to participate in the study. Responders were examined clinically, and asked to answer a questionnaire […] περισσότερα » Five-year retrospective study on success, survival and incidence of complications of single crowns supported by dental implants alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract Objective To determine the survival and the incidence of biologic and technical complications of implant-supported single crowns after 5 years of function. Material and methods Patients treated with dental implants at the National Dental Centre, Singapore, from 2006 to 2010 were recruited from the Implant Registry and evaluated by two clinicians. One hundred and […] περισσότερα » Anatomy Pathology Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Anatomy Pathology via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your compu… περισσότερα » Surgical and Radiologic Anatomy Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Surgical and Radiologic Anatomy *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your c… περισσότερα » Indian Journal of Radiology and Imaging Alexandros G. SfakianakisστοΑπεικονιστικήΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Indian Journal of Radiology and Imaging : 2016 - 26(2) *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to yo… περισσότερα » Nanomaterials, Vol. 6, Pages 122: Plasma Nanoengineering and Nanofabrication Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα With the recent advances in nanotechnology, plasma nanofabrication has become an exciting new niche because plasma-based approaches can deliver unique structures at the nanoscale that cannot be achieved by other techniques and/or in a more economical and environmentally friendly manner.[…] from #Medicine via ola Kala on Inoreader http://ift.tt/28RzmYq via IFTTT περισσότερα » Highly educated men are more likely to be diagnosed with a brain tumour Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα A new study from Karolinska Institutet published in The Journal of Epidemiology and Community Health shows that people of a higher socioeconomic position are more commonly diagnosed with glioma, the most common form of adult brain tumour. The results are particularly salient for men. The paper is based on a large population study including 4.3 million people born in Sweden between 1911 and 1961 who studied during the period from 1993 to 2010. The results show a correlation between socioeconomic position and the likelihood of being diagnosed with glioma that although found in both … περισσότερα » Returning to KI with the bigger picture Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα During his postdoc period at Harvard University, Ninib Baryawno has learnt to think big, and when he returns to KI next year, he'll be bringing with him a broader view of research. It might sound mad for someone to switch to another research field when about to do their postdoc period overseas. For Ninib Baryawno, however, it was a deliberate choice. As a doctoral student, he studied medulloblastoma, a form of cancer that creates brain tumours in children and that scientists now believe to be a stem cell disease. Ninib knew even then that he wanted to learn more about stem cells, a… περισσότερα » Low-Cost Simulation to Teach Anesthetists' Non-Technical Skills in Rwanda. AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα BACKGROUND: Safe anesthesia care is challenging in developing countries where there are shortages of personnel, drugs, equipment, and training. Anesthetists' Non-technical Skills (ANTS)-task management, team working, situation awareness, and decision making-are difficult to practice well in this context. Cesarean delivery is the most common surgical procedure in sub-Saharan Africa. This pilot study investigates whether a low-cost simulation model, with good psychological fidelity, can be used effectively to teach ANTS during cesarean delivery in Rwanda. METHODS: Study participants w… περισσότερα » Impact of On-Bypass Red Blood Cell Transfusion on Severe Postoperative Morbidity or Mortality in Children. AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα BACKGROUND: Children undergoing cardiac surgery are frequently exposed to red blood cell (RBC) transfusions mainly in the case of hemorrhage or low oxygen transport. However, in this population, RBCs are sometimes added to the cardiopulmonary bypass (CPB) priming solution to maintain a predefined hematocrit on bypass. In this study, we investigated the impact of RBCs added to the CPB on severe postoperative morbidity or mortality. METHODS: This retrospective cohort study was conducted between 2006 and 2012 in a tertiary care level, children's hospital. Children receiving red cells on… περισσότερα » Impact of On-Bypass Red Blood Cell Transfusion on Severe Postoperative Morbidity or Mortality in Children. Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα BACKGROUND: Children undergoing cardiac surgery are frequently exposed to red blood cell (RBC) transfusions mainly in the case of hemorrhage or low oxygen transport. However, in this population, RBCs are sometimes added to the cardiopulmonary bypass (CPB) priming solution to maintain a predefined hematocrit on bypass. In this study, we investigated the impact of RBCs added to the CPB on severe postoperative morbidity or mortality. METHODS: This retrospective cohort study was conducted between 2006 and 2012 in a tertiary care level, children's hospital. Children receiving red cells on… περισσότερα » TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Abstract Transforming acidic coiled-coil protein 2 (TACC2) belongs to TACC family proteins and involved in a variety of cellular processes through interactions with some molecules involved in centrosomes/microtubules dynamics. Mounting evidence suggests that TACCs is implicated in the progression of some human malignancies, but significance of TACC2 protein in breast carcinoma is still unknown. Therefore, […] περισσότερα » Closer adherence to cancer prevention recommendations more effective sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα As part of their cancer prevention efforts, leading cancer organisations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) have published recommendations on diet and physical… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28OUZUe via IFTTT περισσότερα » What Explains Differences in Availability of Community Health-Related Services for Seniors in the United States? sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Objective: This study analyzes the links between planning, the built environment, and availability of health-related community services across U.S. urban and rural communities. Method: We analyze the first national survey of health-related community services for seniors (2010 Maturing of America), covering 1,459 U.S. cities and counties. We tested the influence of morbidity (diabetes and obesity), […] περισσότερα » Off-label and unlicensed medicines to hospitalised children in Norway Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives The aim of this study was to investigate the use of off-label (OL) and unlicensed (UL) medicines to hospitalised children in Norway, to add to the current knowledge on use of medicines in this vulnerable patient group. Methods The study was performed as a cross-sectional prospective study. Medication was classified as on- or off-label based on the comparison with the SmPC regarding age, indication, dosage, route of administration and handling of the product. UL products were classified as imported or pharmacy produced. Key findings More than 90% of children r… περισσότερα » Safe implementation of standard concentration infusions in paediatric intensive care Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objective To evaluate safety, following introduction of standard concentrations of morphine infusions in paediatric critical care. Methods *Implementation*: A multidisciplinary team was convened, and several workstreams designated, including derivation of concentrations, manufacturing, supply, prescribing, administration using smart pump technology, training and evaluation. *Safety Evaluation*: Retrieval of all existing data on medication errors linked to morphine use using our hospital incident reporting system and risk assessment of errors in relation to standard conc… περισσότερα » Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives To investigate the apoptosis-inducing effect and underlying mechanisms of luteolin in cholangiocarcinoma (CCA) cells. Methods Cell viability was determined by sulphorhodamine B. Apoptosis was detected using acridine orange/ethidium bromide dye staining and annexin V/PI staining followed by flow cytometry. The effect of luteolin on the oxidative status of CCA cells was evaluated by measuring intracellular reactive oxygen species (ROS) levels using the dihydroethidium method and quantifying glutathione levels. The mitochondria transmembrane potential (ΔΨm) was … περισσότερα » Synergistic analgesic effect of propofol–alfentanil combination through detecting the inhibition of cAMP signal pathway Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objective The study aims to investigate the possible mechanism of the synergistic analgesic effect of propofol–alfentanil combination. Methods The synergistic analgesic effects of propofol–alfentanil combination in Sprague–Dawley (SD) rats were analysed through the von Frey test. Then, we examined the activity of phospholipase C (PLC) and the intracellular levels of Ca2+ and adenosine 3′, 5′cyclic monophosphate (cAMP) in primary neuronal cells of fetal SD rats. We detected the intracellular Ca2+ concentration by fluorescence and flow cytometry. The PLC activity of the pr… περισσότερα » Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives Carvacrol, a monoterpene widely present in nature, is commonly used in the food industry and in cosmetics, besides to possess a plethora of pharmacological properties, among these also *in vitro* vasorelaxing effects and *in vivo* hypotensive responses. Although in rat aortic rings carvacrol evoked a vasodilatation both in the presence and in the absence of endothelium, in preparations with intact endothelial layer its vasoactive response markedly improved. Methods This study aimed at investigating the mechanism of action responsible for the endothelial compo… περισσότερα » Thyroid Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* thyroid2 via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and … περισσότερα » Cephalalgia Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cephalalgia RSS feed – Preview Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer an… περισσότερα » Thyroid Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* thyroid via Alexandros G.Sfakianakis on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your co… περισσότερα » Spine Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Spine via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can… περισσότερα » Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic post-traumatic neuropathic pain in the ankle and foot: the PREPLANS study Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 2 ώρες Introduction Peripheral neuropathic pain (PNP) associated with trauma is often refractory to treatment. Administration of local anaesthetics (LA) and steroids around injured nerves has been proposed as an option for patients unresponsive to conventional treatments for refractory PNP following trauma. There is insufficient evidence to support a large, potentially expensive, full-scale randomised controlled trial (RCT) that involves comparison of effects of perineural steroids and LA against LA or saline injections on analgesia, physical and psychological functioning, and quality … περισσότερα » What Explains Differences in Availability of Community Health-Related Services for Seniors in the United States? medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Objective: This study analyzes the links between planning, the built environment, and availability of health-related community services across U.S. urban and rural communities. Method: We analyze the first national survey of health-related community services for seniors (2010 Maturing of America), covering 1,459 U.S. cities and counties. We tested the influence of morbidity (diabetes and obesity), […] περισσότερα » Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Uptake and integration of exogenous DNA into the bacterial genome play an important role in the evolution of the pathogen Helicobacter pylori . Here, the authors describe a bimodal pattern of chromosomal integration and show how restriction-modification systems limit the import of heterologous DNA. Nature Communications doi: 10.1038/ncomms11995 Authors: Sebastian Bubendorfer, Juliane Krebes, Ines […] περισσότερα » ASC filament formation serves as a signal amplification mechanism for inflammasomes medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome regulatory pathways. Nature Communications doi: 10.1038/ncomms11929 Authors: Mathias S. Dick, Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller, Petr Broz from #Medicine-SfakianakisAlexandros […] περισσότερα » Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal amplifications as a driving force in progression. Nature Communications doi: 10.1038/ncomms12008 Authors: Peter Ulz, Jelena Belic, […] περισσότερα » Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling. Nature Communications doi: 10.1038/ncomms12047 Authors: Fatemeh Mirzamohammadi, Garyfallia […] περισσότερα » The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article The activation of bacterial mechanosensitive channels is still not fully understood. Here, Bavi et al . show that the N-terminal helix of MscL dynamically couples membrane tension to channel gating, suggesting a conserved mechanism underlying the mechanosensitivity of ion channels of higher organisms. Nature Communications doi: 10.1038/ncomms11984 Authors: Navid Bavi, D. Marien Cortes, Charles […] περισσότερα » Experimental demonstration of the microscopic origin of circular dichroism in two-dimensional metamaterials medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article The effect of Ohmic dissipation in two-dimensional chiral materials has never been experimentally verified. Here, Khanikaev et al . demonstrate that the circular dichroism in a nanostructured metasurface occurs due to handedness-dependent Ohmic heating. Nature Communications doi: 10.1038/ncomms12045 Authors: A. B. Khanikaev, N. Arju, Z. Fan, D. Purtseladze, F. Lu, J. Lee, P. Sarriugarte, […] περισσότερα » Demographic routes to variability and regulation in bird populations medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Why does population variability differ? Sæther et al . show that the magnitude of temporal variation of avian population fluctuations is mainly determined by environmental fluctuations affecting recruitment, whereas regulation of mean population size occurs through density-dependent mortality. Nature Communications doi: 10.1038/ncomms12001 Authors: Bernt-Erik Sæther, Vidar Grøtan, Steinar Engen, Tim Coulson, Peter R. Grant, […] περισσότερα » Influence of orbital symmetry on diffraction imaging with rescattering electron wave packets medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Laser-induced electron diffraction possesses sufficient resolution to resolve nuclear dynamics in molecules, but imaging was thought to depend on the orbital symmetries for the backscattering electrons. Here, the authors image the structure of randomly oriented O 2 and C 2 H 2 molecules and prove the contrary. Nature Communications doi: 10.1038/ncomms11922 Authors: M. G. […] περισσότερα » The biogeography of red snow microbiomes and their role in melting arctic glaciers medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article The Arctic is melting at an unprecedented rate and key drivers are changes in snow and ice albedo. Here, the authors show that red pigmented snow algae play a crucial role in decreasing surface albedo and their patterns for diversity, pigmentation, and consequently albedo, are ubiquitous across the Arctic. Nature Communications doi: 10.1038/ncomms11968 Authors: […]
Summary: The Treacher Collins syndrome is characterized by both soft and hard tissue deficiencies. To reconstruct malar hypoplasia with both soft and hard tissues, we designed a new method using cartilage grafts, Y-V advancement flaps, and Z plasty with tissue expansion.
