Your subscribed feeds are not being updated automatically because this setting is turned off.
You've successfully subscribed to this feed!
Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List.
Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List.
You've successfully subscribed to this feed!
You are viewing a feed that contains frequently updated content. When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in Internet Explorer and other programs. Learn more about feeds.
Today, 23 Ιουνίου 2016, 5 hours ago
OtoRhinoLaryngology & Medicine,New Articles,June 23rd,2016
Journal of the American Academy of Child & Adolescent Psychiatry Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of the American Academy of Child & Adolescent Psychiatry *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downlo… περισσότερα » Journal of the American College of Cardiology Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of the American College of Cardiology Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded … περισσότερα » Journal of Trauma and Acute Care Surgery Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Trauma and Acute Care Surgery - Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to … περισσότερα » Journal of Wound, Ostomy & Continence Nursing Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Wound, Ostomy & Continence Nursing. Volume 43(3) May/June 2016 *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatical… περισσότερα » PLOS Pathogens Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* PLOS Pathogens: New Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be vi… περισσότερα » The Journal of Cell Biology Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* [image: Feed image] The Journal of Cell Biology current issue Untangling Topo IIs function at mitotic centromeres Δευτέρα, 20 Ιουνίου 2016, 4:00:36 μμ | Short, B.[image: Go to full article] Sister chromatids get tangled up during DNA replication and … περισσότερα » Topic-specific mini collections : Immunology (prepared for the 2016 AAI meeting) (HTML) (PDF) Cancer (prepared for the 2016 AACR meeting) 24th Annual Henry Kunkel Society Meeting Neuroscience (PDF) (HTML) Innate Immunity (PDF) Cancer (PDF) T Cells (PDF) Dendritic Cells and Macrophages (PDF) B Cell Immunity/HIV (PDF) Stem Cells and Cancer (PDF) Immunity and Cancer (PDF) Neurodegeneration (PDF) Viral Immunity Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *The Journal of Experimental Medicine* now prints topic-specific mini collections to showcase a handful of our recent publications. Click the links below to download a PDF version of our latest special issues. *Immunology (prepared for the 2016 AAI meeting) (HTML)* *(PDF)* *Cancer (prepared for the 2016 AACR meeting) * *24th Annual Henry Kunkel Society Meeting * *Neuroscience (PDF)* *(HTML)* *Innate Immunity (PDF)* *Cancer (PDF)* *T Cells (PDF)* *Dendritic Cells and Macrophages (PDF)* *B Cell Immunity/HIV (PDF)* *Stem Cells and Cancer (PDF)* *Immunity and Cancer (PDF)* *Neurodegenerat… περισσότερα » The Journal of Experimental Medicine Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in Inter… περισσότερα » Anti-Cancer Agents in Medicinal Chemistry Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Issue of Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Upda… περισσότερα » Climatic Change Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Climatic Change *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can… περισσότερα » Journal for General Philosophy of Science Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Journal for General Philosophy of Science *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded… περισσότερα » Mitigation and Adaptation Strategies for Global Change Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Mitigation and Adaptation Strategies for Global Change *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatical… περισσότερα » Medicine & Science in Sports & Exercise Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Medicine & Science in Sports & Exercise - Featured Articles - Featured Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is auto… περισσότερα » Nature Medicine Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Nature Medicine - Issue - nature.com science feeds *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your c… περισσότερα » NEJM Journal Watch: Physician's First Watch Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* NEJM Journal Watch: Physician's First Watch RSS Feed *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your… περισσότερα » New England Journal of Medicine Interviews Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* New England Journal of Medicine Interviews *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer … περισσότερα » Otology & Neurotology - Current Issue Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Otology & Neurotology - Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and … περισσότερα » Pediatric Allergy, Immunology, and Pulmonology Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Pediatric Allergy, Immunology, and Pulmonology - Table of Contents *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically down… περισσότερα » Clinics in Plastic Surgery Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Clinics in Plastic Surgery *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to you… περισσότερα » British Journal of Cancer Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* British Journal of Cancer - AOP - nature.com science feeds *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded t… περισσότερα » Cancer News Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cancer News – ScienceDaily *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be vie… περισσότερα » Case Reports in Oncology Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* CRO : Last 10 articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed i… περισσότερα » Hellenic Anticancer Research Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Anticancer Research current issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can … περισσότερα » Paralleled comparison of vectors for the generation of CAR-T cells. Alexandros G. SfakianakisστοΘεραπείαΠριν από 22 δευτερόλεπτα T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into T-lymphocytes, equipping CAR-modified T cells with a property of recognizing and attacking antigen-expressing tumor cells in a major histocompatibility complex-independent manner. Here, we summarize the … περισσότερα » Minerals, Vol. 6, Pages 58: Mineralogical and Geochemical Characteristics of the Early Permian Upper No. 3 Coal from Southwestern Shandong, China Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The Upper No. 3 coal of the Early Permian age is a major workable seam in the southwestern Shandong coalfield, which is located in the eastern part of North China. From Early Jurassic to Neogene, the coalfield was subjected to intensive tectonic processes, leading to a significant rearrangement in depth of coal seams. In this paper, three Upper No. 3 coals occurring at −228, −670 and −938 m in the Luxi, Liangbaosi, and Tangkou mines, respectively, were collected to investigate their mineralogical and geochemical characteristics, with emphasis on modes of occurrence and origin of e… περισσότερα » Religions, Vol. 7, Pages 81: "Show Us Your God": Marilla Baker Ingalls and the Power of Religious Objects in Nineteenth-Century Burma Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This essay examines the unusual evangelical work of Marilla Baker Ingalls, an American Baptist missionary to Burma from 1851–1902. By the time of her death in Burma at the age of 75, Ingalls was known as one of the most successful Baptist evangelists among Burmese Buddhists. To understand the extraordinary dynamic of Ingalls' expanding Christian community, this essay focuses on two prominent objects at the Baptist mission: A life-sized dog statue that Ingalls kept chained at the edge of her property and a massive banyan tree covered with biblical illustrations and revered by locals… περισσότερα » Information, Vol. 7, Pages 36: Standard Compliant Hazard and Threat Analysis for the Automotive Domain Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The automotive industry has successfully collaborated to release the ISO 26262 standard for developing safe software for cars. The standard describes in detail how to conduct hazard analysis and risk assessments to determine the necessary safety measures for each feature. However, the standard does not concern threat analysis for malicious attackers or how to select appropriate security countermeasures. We propose the application of ISO 27001 for this purpose and show how it can be applied together with ISO 26262. We show how ISO 26262 documentation can be re-used and enhanced to … περισσότερα » Energies, Vol. 9, Pages 481: A Review of CO2-Enhanced Oil Recovery with a Simulated Sensitivity Analysis Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This paper reports on a comprehensive study of the CO2-EOR (Enhanced oil recovery) process, a detailed literature review and a numerical modelling study. According to past studies, CO2 injection can recover additional oil from reservoirs by reservoir pressure increment, oil swelling, the reduction of oil viscosity and density and the vaporization of oil hydrocarbons. Therefore, CO2-EOR can be used to enhance the two major oil recovery mechanisms in the field: miscible and immiscible oil recovery, which can be further increased by increasing the amount of CO2 injected, applying inn… περισσότερα » Religions, Vol. 7, Pages 80: Speculating the Subject of Money: Georg Simmel on Human Value Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This article initiates an inquiry into the sources and frameworks of value used to denote human subjects in modernity. In particular, I consider the conflation of monetary, legal, and theological registers employed to demarcate human worth. Drawing on Simmel's speculative genealogy of the money equivalent of human values, I consider the spectrum of ascriptions from specifically quantified to infinite human value. I suggest that predications of infinite human value require and imply quantified—and specifically monetary-economic—human value. Cost and worth, economically and legally … περισσότερα » Sensors, Vol. 16, Pages 947: Electronic Noses for Well-Being: Breath Analysis and Energy Expenditure Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The wealth of information concealed in a single human breath has been of interest for many years, promising not only disease detection, but also the monitoring of our general well-being. Recent developments in the fields of nano-sensor arrays and MEMS have enabled once bulky artificial olfactory sensor systems, or so-called "electronic noses", to become smaller, lower power and portable devices. At the same time, wearable health monitoring devices are now available, although reliable breath sensing equipment is somewhat missing from the market of physical, rather than chemical sens… περισσότερα » IJGI, Vol. 5, Pages 102: Exploring the Influence of Neighborhood Characteristics on Burglary Risks: A Bayesian Random Effects Modeling Approach Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα A Bayesian random effects modeling approach was used to examine the influence of neighborhood characteristics on burglary risks in Jianghan District, Wuhan, China. This random effects model is essentially spatial; a spatially structured random effects term and an unstructured random effects term are added to the traditional non-spatial Poisson regression model. Based on social disorganization and routine activity theories, five covariates extracted from the available data at the neighborhood level were used in the modeling. Three regression models were fitted and compared by the d… περισσότερα » Sensors, Vol. 16, Pages 950: The β-Lactamase Assay: Harnessing a FRET Biosensor to Analyse Viral Fusion Mechanisms Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The β-lactamase (BlaM) assay was first revealed in 1998 and was demonstrated to be a robust Förster resonance energy transfer (FRET)-based reporter system that was compatible with a range of commonly-used cell lines. Today, the BlaM assay is available commercially as a kit and can be utilised readily and inexpensively for an array of experimental procedures that require a fluorescence-based readout. One frequent application of the BlaM assay is the measurement of viral fusion—the moment at which the genetic material harboured within virus particles is released into the cytosol fol… περισσότερα » Sensors, Vol. 16, Pages 945: An Efficient Implementation of Fixed Failure-Rate Ratio Test for GNSS Ambiguity Resolution Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Ambiguity Resolution (AR) plays a vital role in precise GNSS positioning. Correctly-fixed integer ambiguities can significantly improve the positioning solution, while incorrectly-fixed integer ambiguities can bring large positioning errors and, therefore, should be avoided. The ratio test is an extensively used test to validate the fixed integer ambiguities. To choose proper critical values of the ratio test, the Fixed Failure-rate Ratio Test (FFRT) has been proposed, which generates critical values according to user-defined tolerable failure rates. This contribution provides eas… περισσότερα » Humanities, Vol. 5, Pages 48: Zombies and Refugees: Variations on the "Post-human" and the "Non-human" in Robin Campillo's Les Revenants (2004) and Fabrice Gobert's Les Revenants (2012–2015) Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This article examines the use of the zombie (or the "returned," the literal translation of the French term "revenant") in Fabrice Gobert's French series Les Revenants (2012–2015) as a narrative trope that evokes the recent wave of migration from Syria into Europe. In parallel, this article addresses Robin Campillo's 2004 original feature Les Revenants as it served as an inspiration for Gobert's work in 2012. Campillo's work, like Gobert's, is rooted in the treatment of refugees in France. Following the forceful closing of the Sangatte refugee camp in Calais in 2002, the Moroccan-b… περισσότερα » Toxins, Vol. 8, Pages 193: Tempo and Mode of the Evolution of Venom and Poison in Tetrapods Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Toxic weaponry in the form of venom and poison has evolved in most groups of animals, including all four major lineages of tetrapods. Moreover, the evolution of such traits has been linked to several key aspects of the biology of toxic animals including life-history and diversification. Despite this, attempts to investigate the macroevolutionary patterns underlying such weaponry are lacking. In this study we analyse patterns of venom and poison evolution across reptiles, amphibians, mammals, and birds using a suite of phylogenetic comparative methods. We find that each major linea… περισσότερα » Low-Dose Carotid Computed Tomography Angiography Using Pure Iterative Reconstruction. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The aim of this study was to assess if a low-dose carotid computed tomography angiography (CTA) performed with pure iterative reconstruction (IR) is comparable to a conventional dose CTA protocol. Methods: Twenty patients were included. Radiation dose was divided into a low-dose acquisition reconstructed with pure IR and a conventional dose acquisition reconstructed with 40% hybrid IR. Dose, image noise, contrast resolution, spatial resolution, and carotid artery stenosis were measured. Results: Mean effective dose was significantly lower for low-dose than conventional do… περισσότερα » Computed Tomography Imaging of a Hip Prosthesis Using Iterative Model-Based Reconstruction and Orthopaedic Metal Artefact Reduction: A Quantitative Analysis. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objectives: To quantify the combined use of iterative model-based reconstruction (IMR) and orthopaedic metal artefact reduction (O-MAR) in reducing metal artefacts and improving image quality in a total hip arthroplasty phantom. Methods: Scans acquired at several dose levels and kVps were reconstructed with filtered back-projection (FBP), iterative reconstruction (iDose4) and IMR, with and without O-MAR. Computed tomography (CT) numbers, noise levels, signal-to-noise-ratios and contrast-to-noise-ratios were analysed. Results: Iterative model-based reconstruction results in overall i… περισσότερα » Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI). Methods: A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR i… περισσότερα » Active Surveillance of Small Renal Masses: A Review on the Role of Imaging With a Focus on Growth Rate. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: This study aimed to systematically summarize the current literature in the field of active surveillance for small renal masses, with the primary focus being the role of imaging in the primary decision-making and subsequent follow-up. Materials: A systematic review of the electronic databases PubMed and Web of Knowledge was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analysis statement guidelines. Variables were extracted from the data set and included the following: (1) patient demographics, (2) tumor characteristics, and (3) study des… περισσότερα » Renal Cell Carcinoma: Accuracy of Multidetector Computed Tomography in the Assessment of Renal Sinus Fat Invasion. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Purpose: The purpose of this study was to evaluate the accuracy of multidetector computed tomography (MDCT) in the preoperative assessment of renal sinus fat invasion (RSFI) in patients with renal cell carcinoma (RCC) and to assess imaging features that improve detection of RSFI on CT. Methods: This is a single-institution retrospective review of 53 consecutive patients with histologically proven RCC who underwent triple-phase preoperative contrast MDCT prior to partial or radical nephrectomy. Two experienced radiologists (R1 and R2), blinded to the final histology result, independe… περισσότερα » Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα We present a case of a 30-year-old woman who, while undergoing infertility evaluation, was found to have a large cystic cervical mass, shown to be cystic cervicitis on cervical cone biopsy. Differential diagnosis for benign cystic cervical lesions includes Nabothian cysts, tunnel cluster, endocervical hyperplasia, and cervicitis, whereas cystic cervical malignancies include adenocarcinoma and adenoma malignum. While it is crucial to differentiate benign from malignant lesions, imaging characteristics often overlap and may not provide a specific diagnosis. In difficult cases, definit… περισσότερα » Contrast-Enhanced Dixon Fat-Water Separation Imaging of the Spine: Added Value of Fat, In-Phase and Opposed-Phase Imaging in Marrow Lesion Detection. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: Beyond fat suppression (FS), the efficacy of (fat-water separation or Dixon [FWD]) Dixon imaging in gadolinium-enhanced spine imaging has yet to be validated. This study evaluated enhanced opposed-phase (OP) and fat-only (FO) images along with water-only (WO; FS) images against traditional unenhanced techniques and rated the incremental value of in-phase imaging in patients with presumed neoplastic focal spine lesions. Methods: A retrospective cohort study of 36 subjects with focal spine lesions imaged with FWD was evaluated qualitatively and quantitatively. Results: Enha… περισσότερα » Comparison of Knowledge-based Iterative Model Reconstruction and Hybrid Reconstruction Techniques for Liver CT Evaluation of Hypervascular Hepatocellular Carcinoma. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The purpose of this work was to evaluate the image quality, lesion conspicuity, and dose reduction provided by knowledge-based iterative model reconstruction (IMR) in computed tomography (CT) of the liver compared with hybrid iterative reconstruction (IR) and filtered back projection (FBP) in patients with hepatocellular carcinoma (HCC). Methods: Fifty-six patients with 61 HCCs who underwent multiphasic reduced-dose CT (RDCT; n = 33) or standard-dose CT (SDCT; n = 28) were retrospectively evaluated. Reconstructed images with FBP, hybrid IR (iDose4), IMR were evaluated for… περισσότερα » Periprosthetic Artifact Reduction Using Virtual Monochromatic Imaging Derived From Gemstone Dual-Energy Computed Tomography and Dedicated Software. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The aim of this study was to explore the usefulness of combined virtual monochromatic imaging and metal artifact reduction software (MARS) for the evaluation of musculoskeletal periprosthetic tissue. Methods: Measurements were performed in periprosthetic and remote regions in 80 patients using a high-definition scanner. Polychromatic images with and without MARS and virtual monochromatic images were obtained. Results: Periprosthetic polychromatic imaging (PI) showed significant differences compared with remote areas among the 3 tissues explored (P from #Medicine via ola K… περισσότερα » Volumetric Single-Beat Coronary Computed Tomography Angiography: Relationship of Image Quality, Heart Rate, and Body Mass Index. Initial Patient Experience With a New Computed Tomography Scanner. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Background: Cardiac computed tomography (CT) image quality (IQ) is very important for accurate diagnosis. We propose to evaluate IQ expressed as Likert scale, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) from coronary CT angiography images acquired with a new volumetric single-beat CT scanner on consecutive patients and assess the IQ dependence on heart rate (HR) and body mass index (BMI). Methods: We retrospectively analyzed the data of the first 439 consecutive patients (mean age, 55.13 [SD, 12.1] years; 51.47% male), who underwent noninvasive coronary CT angiogr… περισσότερα » Cell Host & Microbe Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 31 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Host & Microbe *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your compu… περισσότερα » Current Opinion in Immunology Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 31 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Current Opinion in Immunology *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to … περισσότερα » Cell Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cell via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can … περισσότερα » Cell Reports Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Reports *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and… περισσότερα » Cell Metabolism Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Metabolism *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer … περισσότερα » Behavioral and Psychological Symptoms and Caregiver Burden in Mexican Alzheimer's Disease Patients sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
The post Behavioral and Psychological Symptoms and Caregiver Burden in Mexican Alzheimer's Disease Patients appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28REb3W via IFTTT περισσότερα » The Havoc of a Giant Spleen sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
The post The Havoc of a Giant Spleen appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28NGUaO via IFTTT περισσότερα » Economic Approaches to Understanding Change in Happiness sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Are people condemned to an inherent level of experienced happiness? A review of the economic research on subjective well-being gives reason to the assessment that happiness can change. First, empirical findings clearly indicate that people are not indifferent to adverse living conditions when reporting their subjective well-being as observed for limited freedom of choice, low […] περισσότερα » Proteomic analysis of docetaxel resistance in human nasopharyngeal carcinoma cells using the two-dimensional gel electrophoresis method. sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months. Two-dimensional gel electrophoresis and ESI-Q-TOF-MS were used to compare the differential expression of docetaxel-resistance-associated […] περισσότερα » Paralleled comparison of vectors for the generation of CAR-T cells. sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into […] περισσότερα » Flipping a Dental Anatomy Course: A Retrospective Study Over Four Years sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Flipped classrooms have been successfully used to increase student engagement and support student learning in a range of educational fields, including health education. These advantages for student learning supported implementation of the flipped classroom in introductory sciences and preclinical courses in dental education. We report on a 4-year retrospective study which compared two methods of […] περισσότερα » Experimental Study on Detection of Deterioration in Concrete Using Infrared Thermography Technique sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Concrete is certainly prone to internal deteriorations or defects during the construction and operating periods. Compared with other nondestructive techniques, infrared thermography can easily detect the subsurface delamination in a very short period of time, but accurately identifying its size and depth in concrete is a very challenging task. In this study, experimental testing was […] περισσότερα » Quiz: 5 common summer injuries and how to prevent and treat them – KSL.com sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Quiz: 5 common summer injuries and how to prevent and treat them KSL.com If you find yourself paying the price of some summer sun-worshipping, The Skin Cancer Foundation recommends cooling your skin down as soon as possible, moisturizing the skin while damp, take or use an anti-inflammatory medication like ibuprofen or … and more » […] περισσότερα » A Decade of Becoming — Saying Goodbye To My Thirties – Huffington Post sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Huffington Post A Decade of Becoming — Saying Goodbye To My Thirties Huffington Post At 31 and at 34 I've lost two very important people in my life to cancer. After burying my head in the sand for long … I've stopped making excuses at 36 and started writing in a language that wasn't my […] περισσότερα » No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα 
Abstract In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph-angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two-stage analysis: First, 381 polymorphisms from 30 genes (eight Vascular Endothelial Growth Factor (VEGF) and 22 Matrix Metalloproteinase [MMP] genes) […] περισσότερα » Effect of Toothbrushing Frequency on Incidence and Increment of Dental Caries: A Systematic Review and Meta-Analysis Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Toothbrushing is considered fundamental self-care behavior for maintenance of oral health, and brushing twice a day has become a social norm, but the evidence base for this frequency is weak. This systematic review and meta-analysis aims to assess the effect of toothbrushing frequency on the incidence and increment of carious lesions. Medline, Embase, Cinahl, and Cochrane databases were searched. Screening and quality assessment were performed by 2 independent reviewers. Three different meta-analyses were conducted: 2 based on the caries outcome reported in the studies (incidence … περισσότερα » Patient-related outcome measures with implant therapy after 5 years Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objective To analyze patients' perception of implant therapy in partial edentulism, after 5 years with implant-supported reconstructions. Material and methods Patients who received dental implants at the National Dental Centre, Singapore 3–9 years earlier (mean: 5.2 years) were invited to participate in the study. Responders were examined clinically, and asked to answer a questionnaire with 13 statements. Results Of the 880 patients, 206 patients, with 329 implants, agreed to participate. Of the implants, 82% supported single crowns, while 18% were reconstructed with splin… περισσότερα » Five-year retrospective study on success, survival and incidence of complications of single crowns supported by dental implants Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objective To determine the survival and the incidence of biologic and technical complications of implant-supported single crowns after 5 years of function. Material and methods Patients treated with dental implants at the National Dental Centre, Singapore, from 2006 to 2010 were recruited from the Implant Registry and evaluated by two clinicians. One hundred and ninety-four patients, with 266 implant single crowns (SCs), were examined clinically for biologic and technical parameters. Digital radiographs were also obtained. Failure and complication rates were calculated base… περισσότερα » Radiographic and histological evaluation of deproteinized bovine bone mineral vs. deproteinized bovine bone mineral with 10% collagen in ridge preservation. A randomized controlled clinical trial Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objectives The aims of this randomized clinical trial were to compare the dimensional changes and the histological composition after using deproteinized bovine bone mineral (DBBM) or deproteinized bovine bone mineral with 10% collagen (DBBM-C) and a collagen membrane in ridge preservation procedures. Material and methods Patients who required an extraction and a subsequent implant-supported rehabilitation at a non-molar site were recruited. After extraction, a cone beam computed tomography (CBCT) was performed and sites were randomly treated either with DBBM or DBBM-C plus … περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα *Background:* Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. *Methods:* Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated… περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα *Background:* Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. *Methods:* Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated… περισσότερα » Mentoring Early-Career Faculty Researchers Is Important-But First «Train the Trainer». medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
It has long been known that mentoring is critical to the success of junior faculty researchers. The controlled intervention study by Libby et al published in this issue of Academic Medicine demonstrates that institutional investment in a mentored research career development program for early-career faculty investigators provided significant long-term gains in grant productivity. Academic institutions […] περισσότερα » The Teachers of Quality Academy: A Learning Community Approach to Preparing Faculty to Teach Health Systems Science. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Problem: Although efforts to integrate health systems science (HSS) topics, such as patient safety, quality improvement (QI), interprofessionalism, and population health, into health professions curricula are increasing, the rate of change has been slow. Approach: The Teachers of Quality Academy (TQA), Brody School of Medicine at East Carolina University, was established in January 2014 with […] περισσότερα » Targeting TOPK in ovarian cancer medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Background; We aimed to clarify the clinical significance of TOPK (T-lymphokine-activated killer cell-originated protein kinase) expression in ovarian cancer and evaluate the possible effect of TOPK inhibitors, OTS514 and OTS964, on ovarian cancer cells. Methods; TOPK expression was examined by immunohistochemistry using 163 samples with epithelial ovarian cancer (EOC). TOPK protein level and FOXM1 transcriptional […] περισσότερα » Genomic alterations in salivary adenocarcinoma medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Purpose: We sought to identify genomic alterations (GAs) in salivary gland adenocarcinomas, not otherwise specified (NOS), salivary duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca ex PA), and salivary carcinoma, NOS. Experimental design: DNA was extracted from 149 tumors. Comprehensive genomic profiling (CGP) was performed on hybridization-captured adaptor ligation-based libraries of 182 or 315 cancer-related […] περισσότερα » Mutational analysis of cfDNA and single CTCs in MBC medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Purpose: The purpose of this study was to directly compare mutation profiles in multiple single CTCs and cfDNA isolated from the same blood samples taken from patients with metastaic breast cancer (MBC). We aimed to determine whether cell-free DNA would reflect the heterogeneity observed in 40 single CTCs. Experimental design: CTCs were enumerated by Cellsearch. […] περισσότερα » Tumor Microenvironment in Gene Expression Signatures medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
The tumor microenvironment contributes important information in gene expression signatures but may be susceptible to sampling variance. Mesenchymal signatures in particular may be influenced by sampling of non-representative regions with high stromal content. Appropriate pathology quality control is required to ensure reproducibility of gene expression signatures. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Pgw0K via IFTTT […] περισσότερα » CSF-1R and NLC in CLL medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Purpose:Monocytes and their progeny are abundant constituents of the tumor microenvironment in lymphoproliferative disorders, including chronic lymphocytic leukemia (CLL). Monocyte-derived cells, including nurse-like cells (NLC) in CLL, promote lymphocyte proliferation and survival, confer resistance to chemotherapy, and are associated with more rapid disease progression. Colony-stimulating factor-1 receptor (CSF-1R) regulates the homeostatic survival of tissue-resident macrophages. […] περισσότερα » Past participle formation in specific language impairment. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
CONCLUSIONS & IMPLICATIONS: In contrast to earlier findings, the present results demonstrate that regular participle formation is problematic for German children with SLI. PMID: 27321811 [PubMed – as supplied by publisher] (Source: International Journal of Language and Communication Disorders) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28NGaCL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete […] περισσότερα » Oxford Handbook of Anaesthesia, 4th ed. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
No abstract available from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Rykvb via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα » The Biomechanical Effects of Resuscitation Colloids on the Compromised Lung Endothelial Glycocalyx. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
BACKGROUND: The endothelial glycocalyx is an important component of the vascular permeability barrier, forming a scaffold that allows serum proteins to create a gel-like layer on the endothelial surface and transmitting mechanosensing and mechanotransduction information that influences permeability. During acute inflammation, the glycocalyx is degraded, changing how it interacts with serum proteins and colloids used […] περισσότερα » First case of Currarino Syndrome and Trimethylaminuria: two rare diseases for a complex clinical presentation otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/28X47ao via IFTTT http://ift.tt/28RoF7N περισσότερα » First case of Currarino Syndrome and Trimethylaminuria: two rare diseases for a complex clinical presentation Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/28X47ao via IFTTT περισσότερα » No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph-angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two-stage analysis: First, 381 polymorphisms from 30 genes (eight Vascular Endothelial Growth Factor (VEGF) and 22 Matrix Metalloproteinase [MMP] genes) […] περισσότερα » Genetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract RAD51B plays a central role in homologous recombinational repair (HRR) of DNA double-strand breaks (DSBs), which is important to prevent genomic instability, a hallmark of cancer. Recent studies suggested that common genetic variants of RAD51B may contribute to cancer susceptibility. In this study, we aimed to investigate whether potentially functional variants within miRNA-binding sites […] περισσότερα » Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract The carboxyl terminus of the Hsc70-interacting protein (CHIP) is considered to induce the ubiquitination and degradation of several oncogenic proteins, and play a role in the inhibition of tumor progression and invasion under experimental conditions. However, the impact of CHIP expression on the prognosis of breast cancer patients has not yet been established. In […] περισσότερα » Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain […] περισσότερα » RRM1 *151A>T, RRM1 -756T>C, and RRM1 -585T>Gis associated with increased susceptibility of lung cancer in Chinese patients alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract Ribonucleotide reductase M1 (RRM1) is a crucial gene in DNA repair. Recent studies have shown that RRM1 expression can be a powerful predictor of survival or chemotherapy sensitivity in patients presenting with carcinomas who are treated with adjuvant gemcitabine-based chemotherapy including lung cancer. However, the relationship between the single nucleotide polymorphisms (SNP) of RRM1 […] περισσότερα » TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract Transforming acidic coiled-coil protein 2 (TACC2) belongs to TACC family proteins and involved in a variety of cellular processes through interactions with some molecules involved in centrosomes/microtubules dynamics. Mounting evidence suggests that TACCs is implicated in the progression of some human malignancies, but significance of TACC2 protein in breast carcinoma is still unknown. Therefore, […] περισσότερα » Closer adherence to cancer prevention recommendations more effective alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
As part of their cancer prevention efforts, leading cancer organisations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) have published recommendations on diet and physical… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/28OUZUe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we […] περισσότερα » Patient-related outcome measures with implant therapy after 5 years alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract Objective To analyze patients' perception of implant therapy in partial edentulism, after 5 years with implant-supported reconstructions. Material and methods Patients who received dental implants at the National Dental Centre, Singapore 3–9 years earlier (mean: 5.2 years) were invited to participate in the study. Responders were examined clinically, and asked to answer a questionnaire […] περισσότερα » Five-year retrospective study on success, survival and incidence of complications of single crowns supported by dental implants alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα 
Abstract Objective To determine the survival and the incidence of biologic and technical complications of implant-supported single crowns after 5 years of function. Material and methods Patients treated with dental implants at the National Dental Centre, Singapore, from 2006 to 2010 were recruited from the Implant Registry and evaluated by two clinicians. One hundred and […] περισσότερα » Anatomy Pathology Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Anatomy Pathology via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your compu… περισσότερα » Surgical and Radiologic Anatomy Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Surgical and Radiologic Anatomy *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your c… περισσότερα » Indian Journal of Radiology and Imaging Alexandros G. SfakianakisστοΑπεικονιστικήΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Indian Journal of Radiology and Imaging : 2016 - 26(2) *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to yo… περισσότερα » Nanomaterials, Vol. 6, Pages 122: Plasma Nanoengineering and Nanofabrication Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα With the recent advances in nanotechnology, plasma nanofabrication has become an exciting new niche because plasma-based approaches can deliver unique structures at the nanoscale that cannot be achieved by other techniques and/or in a more economical and environmentally friendly manner.[…] from #Medicine via ola Kala on Inoreader http://ift.tt/28RzmYq via IFTTT περισσότερα » Highly educated men are more likely to be diagnosed with a brain tumour Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα A new study from Karolinska Institutet published in The Journal of Epidemiology and Community Health shows that people of a higher socioeconomic position are more commonly diagnosed with glioma, the most common form of adult brain tumour. The results are particularly salient for men. The paper is based on a large population study including 4.3 million people born in Sweden between 1911 and 1961 who studied during the period from 1993 to 2010. The results show a correlation between socioeconomic position and the likelihood of being diagnosed with glioma that although found in both … περισσότερα » Returning to KI with the bigger picture Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα During his postdoc period at Harvard University, Ninib Baryawno has learnt to think big, and when he returns to KI next year, he'll be bringing with him a broader view of research. It might sound mad for someone to switch to another research field when about to do their postdoc period overseas. For Ninib Baryawno, however, it was a deliberate choice. As a doctoral student, he studied medulloblastoma, a form of cancer that creates brain tumours in children and that scientists now believe to be a stem cell disease. Ninib knew even then that he wanted to learn more about stem cells, a… περισσότερα » Low-Cost Simulation to Teach Anesthetists' Non-Technical Skills in Rwanda. AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα BACKGROUND: Safe anesthesia care is challenging in developing countries where there are shortages of personnel, drugs, equipment, and training. Anesthetists' Non-technical Skills (ANTS)-task management, team working, situation awareness, and decision making-are difficult to practice well in this context. Cesarean delivery is the most common surgical procedure in sub-Saharan Africa. This pilot study investigates whether a low-cost simulation model, with good psychological fidelity, can be used effectively to teach ANTS during cesarean delivery in Rwanda. METHODS: Study participants w… περισσότερα » Impact of On-Bypass Red Blood Cell Transfusion on Severe Postoperative Morbidity or Mortality in Children. AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα BACKGROUND: Children undergoing cardiac surgery are frequently exposed to red blood cell (RBC) transfusions mainly in the case of hemorrhage or low oxygen transport. However, in this population, RBCs are sometimes added to the cardiopulmonary bypass (CPB) priming solution to maintain a predefined hematocrit on bypass. In this study, we investigated the impact of RBCs added to the CPB on severe postoperative morbidity or mortality. METHODS: This retrospective cohort study was conducted between 2006 and 2012 in a tertiary care level, children's hospital. Children receiving red cells on… περισσότερα » Impact of On-Bypass Red Blood Cell Transfusion on Severe Postoperative Morbidity or Mortality in Children. Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα BACKGROUND: Children undergoing cardiac surgery are frequently exposed to red blood cell (RBC) transfusions mainly in the case of hemorrhage or low oxygen transport. However, in this population, RBCs are sometimes added to the cardiopulmonary bypass (CPB) priming solution to maintain a predefined hematocrit on bypass. In this study, we investigated the impact of RBCs added to the CPB on severe postoperative morbidity or mortality. METHODS: This retrospective cohort study was conducted between 2006 and 2012 in a tertiary care level, children's hospital. Children receiving red cells on… περισσότερα » TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Abstract Transforming acidic coiled-coil protein 2 (TACC2) belongs to TACC family proteins and involved in a variety of cellular processes through interactions with some molecules involved in centrosomes/microtubules dynamics. Mounting evidence suggests that TACCs is implicated in the progression of some human malignancies, but significance of TACC2 protein in breast carcinoma is still unknown. Therefore, […] περισσότερα » Closer adherence to cancer prevention recommendations more effective sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
As part of their cancer prevention efforts, leading cancer organisations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) have published recommendations on diet and physical… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28OUZUe via IFTTT περισσότερα » What Explains Differences in Availability of Community Health-Related Services for Seniors in the United States? sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Objective: This study analyzes the links between planning, the built environment, and availability of health-related community services across U.S. urban and rural communities. Method: We analyze the first national survey of health-related community services for seniors (2010 Maturing of America), covering 1,459 U.S. cities and counties. We tested the influence of morbidity (diabetes and obesity), […] περισσότερα » Off-label and unlicensed medicines to hospitalised children in Norway Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives The aim of this study was to investigate the use of off-label (OL) and unlicensed (UL) medicines to hospitalised children in Norway, to add to the current knowledge on use of medicines in this vulnerable patient group. Methods The study was performed as a cross-sectional prospective study. Medication was classified as on- or off-label based on the comparison with the SmPC regarding age, indication, dosage, route of administration and handling of the product. UL products were classified as imported or pharmacy produced. Key findings More than 90% of children r… περισσότερα » Safe implementation of standard concentration infusions in paediatric intensive care Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objective To evaluate safety, following introduction of standard concentrations of morphine infusions in paediatric critical care. Methods *Implementation*: A multidisciplinary team was convened, and several workstreams designated, including derivation of concentrations, manufacturing, supply, prescribing, administration using smart pump technology, training and evaluation. *Safety Evaluation*: Retrieval of all existing data on medication errors linked to morphine use using our hospital incident reporting system and risk assessment of errors in relation to standard conc… περισσότερα » Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives To investigate the apoptosis-inducing effect and underlying mechanisms of luteolin in cholangiocarcinoma (CCA) cells. Methods Cell viability was determined by sulphorhodamine B. Apoptosis was detected using acridine orange/ethidium bromide dye staining and annexin V/PI staining followed by flow cytometry. The effect of luteolin on the oxidative status of CCA cells was evaluated by measuring intracellular reactive oxygen species (ROS) levels using the dihydroethidium method and quantifying glutathione levels. The mitochondria transmembrane potential (ΔΨm) was … περισσότερα » Synergistic analgesic effect of propofol–alfentanil combination through detecting the inhibition of cAMP signal pathway Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objective The study aims to investigate the possible mechanism of the synergistic analgesic effect of propofol–alfentanil combination. Methods The synergistic analgesic effects of propofol–alfentanil combination in Sprague–Dawley (SD) rats were analysed through the von Frey test. Then, we examined the activity of phospholipase C (PLC) and the intracellular levels of Ca2+ and adenosine 3′, 5′cyclic monophosphate (cAMP) in primary neuronal cells of fetal SD rats. We detected the intracellular Ca2+ concentration by fluorescence and flow cytometry. The PLC activity of the pr… περισσότερα » Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives Carvacrol, a monoterpene widely present in nature, is commonly used in the food industry and in cosmetics, besides to possess a plethora of pharmacological properties, among these also *in vitro* vasorelaxing effects and *in vivo* hypotensive responses. Although in rat aortic rings carvacrol evoked a vasodilatation both in the presence and in the absence of endothelium, in preparations with intact endothelial layer its vasoactive response markedly improved. Methods This study aimed at investigating the mechanism of action responsible for the endothelial compo… περισσότερα » Thyroid Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* thyroid2 via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and … περισσότερα » Cephalalgia Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cephalalgia RSS feed – Preview Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer an… περισσότερα » Thyroid Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* thyroid via Alexandros G.Sfakianakis on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your co… περισσότερα » Spine Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Spine via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can… περισσότερα » Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic post-traumatic neuropathic pain in the ankle and foot: the PREPLANS study Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 2 ώρες Introduction Peripheral neuropathic pain (PNP) associated with trauma is often refractory to treatment. Administration of local anaesthetics (LA) and steroids around injured nerves has been proposed as an option for patients unresponsive to conventional treatments for refractory PNP following trauma. There is insufficient evidence to support a large, potentially expensive, full-scale randomised controlled trial (RCT) that involves comparison of effects of perineural steroids and LA against LA or saline injections on analgesia, physical and psychological functioning, and quality … περισσότερα » What Explains Differences in Availability of Community Health-Related Services for Seniors in the United States? medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Objective: This study analyzes the links between planning, the built environment, and availability of health-related community services across U.S. urban and rural communities. Method: We analyze the first national survey of health-related community services for seniors (2010 Maturing of America), covering 1,459 U.S. cities and counties. We tested the influence of morbidity (diabetes and obesity), […] περισσότερα » Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Uptake and integration of exogenous DNA into the bacterial genome play an important role in the evolution of the pathogen Helicobacter pylori . Here, the authors describe a bimodal pattern of chromosomal integration and show how restriction-modification systems limit the import of heterologous DNA. Nature Communications doi: 10.1038/ncomms11995 Authors: Sebastian Bubendorfer, Juliane Krebes, Ines […] περισσότερα » ASC filament formation serves as a signal amplification mechanism for inflammasomes medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome regulatory pathways. Nature Communications doi: 10.1038/ncomms11929 Authors: Mathias S. Dick, Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller, Petr Broz from #Medicine-SfakianakisAlexandros […] περισσότερα » Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal amplifications as a driving force in progression. Nature Communications doi: 10.1038/ncomms12008 Authors: Peter Ulz, Jelena Belic, […] περισσότερα » Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling. Nature Communications doi: 10.1038/ncomms12047 Authors: Fatemeh Mirzamohammadi, Garyfallia […] περισσότερα » The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article The activation of bacterial mechanosensitive channels is still not fully understood. Here, Bavi et al . show that the N-terminal helix of MscL dynamically couples membrane tension to channel gating, suggesting a conserved mechanism underlying the mechanosensitivity of ion channels of higher organisms. Nature Communications doi: 10.1038/ncomms11984 Authors: Navid Bavi, D. Marien Cortes, Charles […] περισσότερα » Experimental demonstration of the microscopic origin of circular dichroism in two-dimensional metamaterials medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article The effect of Ohmic dissipation in two-dimensional chiral materials has never been experimentally verified. Here, Khanikaev et al . demonstrate that the circular dichroism in a nanostructured metasurface occurs due to handedness-dependent Ohmic heating. Nature Communications doi: 10.1038/ncomms12045 Authors: A. B. Khanikaev, N. Arju, Z. Fan, D. Purtseladze, F. Lu, J. Lee, P. Sarriugarte, […] περισσότερα » Demographic routes to variability and regulation in bird populations medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Why does population variability differ? Sæther et al . show that the magnitude of temporal variation of avian population fluctuations is mainly determined by environmental fluctuations affecting recruitment, whereas regulation of mean population size occurs through density-dependent mortality. Nature Communications doi: 10.1038/ncomms12001 Authors: Bernt-Erik Sæther, Vidar Grøtan, Steinar Engen, Tim Coulson, Peter R. Grant, […] περισσότερα » Influence of orbital symmetry on diffraction imaging with rescattering electron wave packets medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article Laser-induced electron diffraction possesses sufficient resolution to resolve nuclear dynamics in molecules, but imaging was thought to depend on the orbital symmetries for the backscattering electrons. Here, the authors image the structure of randomly oriented O 2 and C 2 H 2 molecules and prove the contrary. Nature Communications doi: 10.1038/ncomms11922 Authors: M. G. […] περισσότερα » The biogeography of red snow microbiomes and their role in melting arctic glaciers medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες 
Article The Arctic is melting at an unprecedented rate and key drivers are changes in snow and ice albedo. Here, the authors show that red pigmented snow algae play a crucial role in decreasing surface albedo and their patterns for diversity, pigmentation, and consequently albedo, are ubiquitous across the Arctic. Nature Communications doi: 10.1038/ncomms11968 Authors: […]from Medicine by Alexandros G. Sfakianakis http://ift.tt/28TDi9r
via IFTTT
OtoRhinoLaryngology & Medicine,New Articles,June 23rd,2016
Journal of the American Academy of Child & Adolescent Psychiatry Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of the American Academy of Child & Adolescent Psychiatry *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downlo… περισσότερα » Journal of the American College of Cardiology Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of the American College of Cardiology Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded … περισσότερα » Journal of Trauma and Acute Care Surgery Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Trauma and Acute Care Surgery - Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to … περισσότερα » Journal of Wound, Ostomy & Continence Nursing Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Wound, Ostomy & Continence Nursing. Volume 43(3) May/June 2016 *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatical… περισσότερα » PLOS Pathogens Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* PLOS Pathogens: New Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be vi… περισσότερα » The Journal of Cell Biology Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* [image: Feed image] The Journal of Cell Biology current issue Untangling Topo IIs function at mitotic centromeres Δευτέρα, 20 Ιουνίου 2016, 4:00:36 μμ | Short, B.[image: Go to full article] Sister chromatids get tangled up during DNA replication and … περισσότερα » Topic-specific mini collections : Immunology (prepared for the 2016 AAI meeting) (HTML) (PDF) Cancer (prepared for the 2016 AACR meeting) 24th Annual Henry Kunkel Society Meeting Neuroscience (PDF) (HTML) Innate Immunity (PDF) Cancer (PDF) T Cells (PDF) Dendritic Cells and Macrophages (PDF) B Cell Immunity/HIV (PDF) Stem Cells and Cancer (PDF) Immunity and Cancer (PDF) Neurodegeneration (PDF) Viral Immunity Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *The Journal of Experimental Medicine* now prints topic-specific mini collections to showcase a handful of our recent publications. Click the links below to download a PDF version of our latest special issues. *Immunology (prepared for the 2016 AAI meeting) (HTML)* *(PDF)* *Cancer (prepared for the 2016 AACR meeting) * *24th Annual Henry Kunkel Society Meeting * *Neuroscience (PDF)* *(HTML)* *Innate Immunity (PDF)* *Cancer (PDF)* *T Cells (PDF)* *Dendritic Cells and Macrophages (PDF)* *B Cell Immunity/HIV (PDF)* *Stem Cells and Cancer (PDF)* *Immunity and Cancer (PDF)* *Neurodegenerat… περισσότερα » The Journal of Experimental Medicine Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in Inter… περισσότερα » Anti-Cancer Agents in Medicinal Chemistry Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Issue of Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Upda… περισσότερα » Climatic Change Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Climatic Change *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can… περισσότερα » Journal for General Philosophy of Science Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Journal for General Philosophy of Science *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded… περισσότερα » Mitigation and Adaptation Strategies for Global Change Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Mitigation and Adaptation Strategies for Global Change *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatical… περισσότερα » Medicine & Science in Sports & Exercise Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Medicine & Science in Sports & Exercise - Featured Articles - Featured Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is auto… περισσότερα » Nature Medicine Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Nature Medicine - Issue - nature.com science feeds *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your c… περισσότερα » NEJM Journal Watch: Physician's First Watch Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* NEJM Journal Watch: Physician's First Watch RSS Feed *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your… περισσότερα » New England Journal of Medicine Interviews Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* New England Journal of Medicine Interviews *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer … περισσότερα » Otology & Neurotology - Current Issue Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Otology & Neurotology - Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and … περισσότερα » Pediatric Allergy, Immunology, and Pulmonology Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Pediatric Allergy, Immunology, and Pulmonology - Table of Contents *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically down… περισσότερα » Clinics in Plastic Surgery Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Clinics in Plastic Surgery *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to you… περισσότερα » British Journal of Cancer Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* British Journal of Cancer - AOP - nature.com science feeds *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded t… περισσότερα » Cancer News Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cancer News – ScienceDaily *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be vie… περισσότερα » Case Reports in Oncology Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* CRO : Last 10 articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed i… περισσότερα » Hellenic Anticancer Research Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Anticancer Research current issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can … περισσότερα » Paralleled comparison of vectors for the generation of CAR-T cells. Alexandros G. SfakianakisστοΘεραπείαΠριν από 22 δευτερόλεπτα T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into T-lymphocytes, equipping CAR-modified T cells with a property of recognizing and attacking antigen-expressing tumor cells in a major histocompatibility complex-independent manner. Here, we summarize the … περισσότερα » Minerals, Vol. 6, Pages 58: Mineralogical and Geochemical Characteristics of the Early Permian Upper No. 3 Coal from Southwestern Shandong, China Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The Upper No. 3 coal of the Early Permian age is a major workable seam in the southwestern Shandong coalfield, which is located in the eastern part of North China. From Early Jurassic to Neogene, the coalfield was subjected to intensive tectonic processes, leading to a significant rearrangement in depth of coal seams. In this paper, three Upper No. 3 coals occurring at −228, −670 and −938 m in the Luxi, Liangbaosi, and Tangkou mines, respectively, were collected to investigate their mineralogical and geochemical characteristics, with emphasis on modes of occurrence and origin of e… περισσότερα » Religions, Vol. 7, Pages 81: "Show Us Your God": Marilla Baker Ingalls and the Power of Religious Objects in Nineteenth-Century Burma Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This essay examines the unusual evangelical work of Marilla Baker Ingalls, an American Baptist missionary to Burma from 1851–1902. By the time of her death in Burma at the age of 75, Ingalls was known as one of the most successful Baptist evangelists among Burmese Buddhists. To understand the extraordinary dynamic of Ingalls' expanding Christian community, this essay focuses on two prominent objects at the Baptist mission: A life-sized dog statue that Ingalls kept chained at the edge of her property and a massive banyan tree covered with biblical illustrations and revered by locals… περισσότερα » Information, Vol. 7, Pages 36: Standard Compliant Hazard and Threat Analysis for the Automotive Domain Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The automotive industry has successfully collaborated to release the ISO 26262 standard for developing safe software for cars. The standard describes in detail how to conduct hazard analysis and risk assessments to determine the necessary safety measures for each feature. However, the standard does not concern threat analysis for malicious attackers or how to select appropriate security countermeasures. We propose the application of ISO 27001 for this purpose and show how it can be applied together with ISO 26262. We show how ISO 26262 documentation can be re-used and enhanced to … περισσότερα » Energies, Vol. 9, Pages 481: A Review of CO2-Enhanced Oil Recovery with a Simulated Sensitivity Analysis Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This paper reports on a comprehensive study of the CO2-EOR (Enhanced oil recovery) process, a detailed literature review and a numerical modelling study. According to past studies, CO2 injection can recover additional oil from reservoirs by reservoir pressure increment, oil swelling, the reduction of oil viscosity and density and the vaporization of oil hydrocarbons. Therefore, CO2-EOR can be used to enhance the two major oil recovery mechanisms in the field: miscible and immiscible oil recovery, which can be further increased by increasing the amount of CO2 injected, applying inn… περισσότερα » Religions, Vol. 7, Pages 80: Speculating the Subject of Money: Georg Simmel on Human Value Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This article initiates an inquiry into the sources and frameworks of value used to denote human subjects in modernity. In particular, I consider the conflation of monetary, legal, and theological registers employed to demarcate human worth. Drawing on Simmel's speculative genealogy of the money equivalent of human values, I consider the spectrum of ascriptions from specifically quantified to infinite human value. I suggest that predications of infinite human value require and imply quantified—and specifically monetary-economic—human value. Cost and worth, economically and legally … περισσότερα » Sensors, Vol. 16, Pages 947: Electronic Noses for Well-Being: Breath Analysis and Energy Expenditure Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The wealth of information concealed in a single human breath has been of interest for many years, promising not only disease detection, but also the monitoring of our general well-being. Recent developments in the fields of nano-sensor arrays and MEMS have enabled once bulky artificial olfactory sensor systems, or so-called "electronic noses", to become smaller, lower power and portable devices. At the same time, wearable health monitoring devices are now available, although reliable breath sensing equipment is somewhat missing from the market of physical, rather than chemical sens… περισσότερα » IJGI, Vol. 5, Pages 102: Exploring the Influence of Neighborhood Characteristics on Burglary Risks: A Bayesian Random Effects Modeling Approach Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα A Bayesian random effects modeling approach was used to examine the influence of neighborhood characteristics on burglary risks in Jianghan District, Wuhan, China. This random effects model is essentially spatial; a spatially structured random effects term and an unstructured random effects term are added to the traditional non-spatial Poisson regression model. Based on social disorganization and routine activity theories, five covariates extracted from the available data at the neighborhood level were used in the modeling. Three regression models were fitted and compared by the d… περισσότερα » Sensors, Vol. 16, Pages 950: The β-Lactamase Assay: Harnessing a FRET Biosensor to Analyse Viral Fusion Mechanisms Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The β-lactamase (BlaM) assay was first revealed in 1998 and was demonstrated to be a robust Förster resonance energy transfer (FRET)-based reporter system that was compatible with a range of commonly-used cell lines. Today, the BlaM assay is available commercially as a kit and can be utilised readily and inexpensively for an array of experimental procedures that require a fluorescence-based readout. One frequent application of the BlaM assay is the measurement of viral fusion—the moment at which the genetic material harboured within virus particles is released into the cytosol fol… περισσότερα » Sensors, Vol. 16, Pages 945: An Efficient Implementation of Fixed Failure-Rate Ratio Test for GNSS Ambiguity Resolution Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Ambiguity Resolution (AR) plays a vital role in precise GNSS positioning. Correctly-fixed integer ambiguities can significantly improve the positioning solution, while incorrectly-fixed integer ambiguities can bring large positioning errors and, therefore, should be avoided. The ratio test is an extensively used test to validate the fixed integer ambiguities. To choose proper critical values of the ratio test, the Fixed Failure-rate Ratio Test (FFRT) has been proposed, which generates critical values according to user-defined tolerable failure rates. This contribution provides eas… περισσότερα » Humanities, Vol. 5, Pages 48: Zombies and Refugees: Variations on the "Post-human" and the "Non-human" in Robin Campillo's Les Revenants (2004) and Fabrice Gobert's Les Revenants (2012–2015) Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This article examines the use of the zombie (or the "returned," the literal translation of the French term "revenant") in Fabrice Gobert's French series Les Revenants (2012–2015) as a narrative trope that evokes the recent wave of migration from Syria into Europe. In parallel, this article addresses Robin Campillo's 2004 original feature Les Revenants as it served as an inspiration for Gobert's work in 2012. Campillo's work, like Gobert's, is rooted in the treatment of refugees in France. Following the forceful closing of the Sangatte refugee camp in Calais in 2002, the Moroccan-b… περισσότερα » Toxins, Vol. 8, Pages 193: Tempo and Mode of the Evolution of Venom and Poison in Tetrapods Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Toxic weaponry in the form of venom and poison has evolved in most groups of animals, including all four major lineages of tetrapods. Moreover, the evolution of such traits has been linked to several key aspects of the biology of toxic animals including life-history and diversification. Despite this, attempts to investigate the macroevolutionary patterns underlying such weaponry are lacking. In this study we analyse patterns of venom and poison evolution across reptiles, amphibians, mammals, and birds using a suite of phylogenetic comparative methods. We find that each major linea… περισσότερα » Low-Dose Carotid Computed Tomography Angiography Using Pure Iterative Reconstruction. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The aim of this study was to assess if a low-dose carotid computed tomography angiography (CTA) performed with pure iterative reconstruction (IR) is comparable to a conventional dose CTA protocol. Methods: Twenty patients were included. Radiation dose was divided into a low-dose acquisition reconstructed with pure IR and a conventional dose acquisition reconstructed with 40% hybrid IR. Dose, image noise, contrast resolution, spatial resolution, and carotid artery stenosis were measured. Results: Mean effective dose was significantly lower for low-dose than conventional do… περισσότερα » Computed Tomography Imaging of a Hip Prosthesis Using Iterative Model-Based Reconstruction and Orthopaedic Metal Artefact Reduction: A Quantitative Analysis. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objectives: To quantify the combined use of iterative model-based reconstruction (IMR) and orthopaedic metal artefact reduction (O-MAR) in reducing metal artefacts and improving image quality in a total hip arthroplasty phantom. Methods: Scans acquired at several dose levels and kVps were reconstructed with filtered back-projection (FBP), iterative reconstruction (iDose4) and IMR, with and without O-MAR. Computed tomography (CT) numbers, noise levels, signal-to-noise-ratios and contrast-to-noise-ratios were analysed. Results: Iterative model-based reconstruction results in overall i… περισσότερα » Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI). Methods: A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR i… περισσότερα » Active Surveillance of Small Renal Masses: A Review on the Role of Imaging With a Focus on Growth Rate. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: This study aimed to systematically summarize the current literature in the field of active surveillance for small renal masses, with the primary focus being the role of imaging in the primary decision-making and subsequent follow-up. Materials: A systematic review of the electronic databases PubMed and Web of Knowledge was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analysis statement guidelines. Variables were extracted from the data set and included the following: (1) patient demographics, (2) tumor characteristics, and (3) study des… περισσότερα » Renal Cell Carcinoma: Accuracy of Multidetector Computed Tomography in the Assessment of Renal Sinus Fat Invasion. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Purpose: The purpose of this study was to evaluate the accuracy of multidetector computed tomography (MDCT) in the preoperative assessment of renal sinus fat invasion (RSFI) in patients with renal cell carcinoma (RCC) and to assess imaging features that improve detection of RSFI on CT. Methods: This is a single-institution retrospective review of 53 consecutive patients with histologically proven RCC who underwent triple-phase preoperative contrast MDCT prior to partial or radical nephrectomy. Two experienced radiologists (R1 and R2), blinded to the final histology result, independe… περισσότερα » Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα We present a case of a 30-year-old woman who, while undergoing infertility evaluation, was found to have a large cystic cervical mass, shown to be cystic cervicitis on cervical cone biopsy. Differential diagnosis for benign cystic cervical lesions includes Nabothian cysts, tunnel cluster, endocervical hyperplasia, and cervicitis, whereas cystic cervical malignancies include adenocarcinoma and adenoma malignum. While it is crucial to differentiate benign from malignant lesions, imaging characteristics often overlap and may not provide a specific diagnosis. In difficult cases, definit… περισσότερα » Contrast-Enhanced Dixon Fat-Water Separation Imaging of the Spine: Added Value of Fat, In-Phase and Opposed-Phase Imaging in Marrow Lesion Detection. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: Beyond fat suppression (FS), the efficacy of (fat-water separation or Dixon [FWD]) Dixon imaging in gadolinium-enhanced spine imaging has yet to be validated. This study evaluated enhanced opposed-phase (OP) and fat-only (FO) images along with water-only (WO; FS) images against traditional unenhanced techniques and rated the incremental value of in-phase imaging in patients with presumed neoplastic focal spine lesions. Methods: A retrospective cohort study of 36 subjects with focal spine lesions imaged with FWD was evaluated qualitatively and quantitatively. Results: Enha… περισσότερα » Comparison of Knowledge-based Iterative Model Reconstruction and Hybrid Reconstruction Techniques for Liver CT Evaluation of Hypervascular Hepatocellular Carcinoma. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The purpose of this work was to evaluate the image quality, lesion conspicuity, and dose reduction provided by knowledge-based iterative model reconstruction (IMR) in computed tomography (CT) of the liver compared with hybrid iterative reconstruction (IR) and filtered back projection (FBP) in patients with hepatocellular carcinoma (HCC). Methods: Fifty-six patients with 61 HCCs who underwent multiphasic reduced-dose CT (RDCT; n = 33) or standard-dose CT (SDCT; n = 28) were retrospectively evaluated. Reconstructed images with FBP, hybrid IR (iDose4), IMR were evaluated for… περισσότερα » Periprosthetic Artifact Reduction Using Virtual Monochromatic Imaging Derived From Gemstone Dual-Energy Computed Tomography and Dedicated Software. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The aim of this study was to explore the usefulness of combined virtual monochromatic imaging and metal artifact reduction software (MARS) for the evaluation of musculoskeletal periprosthetic tissue. Methods: Measurements were performed in periprosthetic and remote regions in 80 patients using a high-definition scanner. Polychromatic images with and without MARS and virtual monochromatic images were obtained. Results: Periprosthetic polychromatic imaging (PI) showed significant differences compared with remote areas among the 3 tissues explored (P from #Medicine via ola K… περισσότερα » Volumetric Single-Beat Coronary Computed Tomography Angiography: Relationship of Image Quality, Heart Rate, and Body Mass Index. Initial Patient Experience With a New Computed Tomography Scanner. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Background: Cardiac computed tomography (CT) image quality (IQ) is very important for accurate diagnosis. We propose to evaluate IQ expressed as Likert scale, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) from coronary CT angiography images acquired with a new volumetric single-beat CT scanner on consecutive patients and assess the IQ dependence on heart rate (HR) and body mass index (BMI). Methods: We retrospectively analyzed the data of the first 439 consecutive patients (mean age, 55.13 [SD, 12.1] years; 51.47% male), who underwent noninvasive coronary CT angiogr… περισσότερα » Cell Host & Microbe Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 31 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Host & Microbe *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your compu… περισσότερα » Current Opinion in Immunology Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 31 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Current Opinion in Immunology *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to … περισσότερα » Cell Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cell via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can … περισσότερα » Cell Reports Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Reports *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and… περισσότερα » Cell Metabolism Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Metabolism *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer … περισσότερα » Behavioral and Psychological Symptoms and Caregiver Burden in Mexican Alzheimer's Disease Patients sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
The post Behavioral and Psychological Symptoms and Caregiver Burden in Mexican Alzheimer's Disease Patients appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28REb3W via IFTTT περισσότερα » The Havoc of a Giant Spleen sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα The post The Havoc of a Giant Spleen appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28NGUaO via IFTTT περισσότερα » Economic Approaches to Understanding Change in Happiness sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Are people condemned to an inherent level of experienced happiness? A review of the economic research on subjective well-being gives reason to the assessment that happiness can change. First, empirical findings clearly indicate that people are not indifferent to adverse living conditions when reporting their subjective well-being as observed for limited freedom of choice, low […] περισσότερα » Proteomic analysis of docetaxel resistance in human nasopharyngeal carcinoma cells using the two-dimensional gel electrophoresis method. sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months. Two-dimensional gel electrophoresis and ESI-Q-TOF-MS were used to compare the differential expression of docetaxel-resistance-associated […] περισσότερα » Paralleled comparison of vectors for the generation of CAR-T cells. sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into […] περισσότερα » Flipping a Dental Anatomy Course: A Retrospective Study Over Four Years sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Flipped classrooms have been successfully used to increase student engagement and support student learning in a range of educational fields, including health education. These advantages for student learning supported implementation of the flipped classroom in introductory sciences and preclinical courses in dental education. We report on a 4-year retrospective study which compared two methods of […] περισσότερα » Experimental Study on Detection of Deterioration in Concrete Using Infrared Thermography Technique sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Concrete is certainly prone to internal deteriorations or defects during the construction and operating periods. Compared with other nondestructive techniques, infrared thermography can easily detect the subsurface delamination in a very short period of time, but accurately identifying its size and depth in concrete is a very challenging task. In this study, experimental testing was […] περισσότερα » Quiz: 5 common summer injuries and how to prevent and treat them – KSL.com sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Quiz: 5 common summer injuries and how to prevent and treat them KSL.com If you find yourself paying the price of some summer sun-worshipping, The Skin Cancer Foundation recommends cooling your skin down as soon as possible, moisturizing the skin while damp, take or use an anti-inflammatory medication like ibuprofen or … and more » […] περισσότερα » A Decade of Becoming — Saying Goodbye To My Thirties – Huffington Post sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Huffington Post A Decade of Becoming — Saying Goodbye To My Thirties Huffington Post At 31 and at 34 I've lost two very important people in my life to cancer. After burying my head in the sand for long … I've stopped making excuses at 36 and started writing in a language that wasn't my […] περισσότερα » No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα Abstract In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph-angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two-stage analysis: First, 381 polymorphisms from 30 genes (eight Vascular Endothelial Growth Factor (VEGF) and 22 Matrix Metalloproteinase [MMP] genes) […] περισσότερα » Effect of Toothbrushing Frequency on Incidence and Increment of Dental Caries: A Systematic Review and Meta-Analysis Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Toothbrushing is considered fundamental self-care behavior for maintenance of oral health, and brushing twice a day has become a social norm, but the evidence base for this frequency is weak. This systematic review and meta-analysis aims to assess the effect of toothbrushing frequency on the incidence and increment of carious lesions. Medline, Embase, Cinahl, and Cochrane databases were searched. Screening and quality assessment were performed by 2 independent reviewers. Three different meta-analyses were conducted: 2 based on the caries outcome reported in the studies (incidence … περισσότερα » Patient-related outcome measures with implant therapy after 5 years Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objective To analyze patients' perception of implant therapy in partial edentulism, after 5 years with implant-supported reconstructions. Material and methods Patients who received dental implants at the National Dental Centre, Singapore 3–9 years earlier (mean: 5.2 years) were invited to participate in the study. Responders were examined clinically, and asked to answer a questionnaire with 13 statements. Results Of the 880 patients, 206 patients, with 329 implants, agreed to participate. Of the implants, 82% supported single crowns, while 18% were reconstructed with splin… περισσότερα » Five-year retrospective study on success, survival and incidence of complications of single crowns supported by dental implants Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objective To determine the survival and the incidence of biologic and technical complications of implant-supported single crowns after 5 years of function. Material and methods Patients treated with dental implants at the National Dental Centre, Singapore, from 2006 to 2010 were recruited from the Implant Registry and evaluated by two clinicians. One hundred and ninety-four patients, with 266 implant single crowns (SCs), were examined clinically for biologic and technical parameters. Digital radiographs were also obtained. Failure and complication rates were calculated base… περισσότερα » Radiographic and histological evaluation of deproteinized bovine bone mineral vs. deproteinized bovine bone mineral with 10% collagen in ridge preservation. A randomized controlled clinical trial Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα Abstract Objectives The aims of this randomized clinical trial were to compare the dimensional changes and the histological composition after using deproteinized bovine bone mineral (DBBM) or deproteinized bovine bone mineral with 10% collagen (DBBM-C) and a collagen membrane in ridge preservation procedures. Material and methods Patients who required an extraction and a subsequent implant-supported rehabilitation at a non-molar site were recruited. After extraction, a cone beam computed tomography (CBCT) was performed and sites were randomly treated either with DBBM or DBBM-C plus … περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα *Background:* Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. *Methods:* Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated… περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα *Background:* Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. *Methods:* Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated… περισσότερα » Mentoring Early-Career Faculty Researchers Is Important-But First «Train the Trainer». medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα It has long been known that mentoring is critical to the success of junior faculty researchers. The controlled intervention study by Libby et al published in this issue of Academic Medicine demonstrates that institutional investment in a mentored research career development program for early-career faculty investigators provided significant long-term gains in grant productivity. Academic institutions […] περισσότερα » The Teachers of Quality Academy: A Learning Community Approach to Preparing Faculty to Teach Health Systems Science. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Problem: Although efforts to integrate health systems science (HSS) topics, such as patient safety, quality improvement (QI), interprofessionalism, and population health, into health professions curricula are increasing, the rate of change has been slow. Approach: The Teachers of Quality Academy (TQA), Brody School of Medicine at East Carolina University, was established in January 2014 with […] περισσότερα » Targeting TOPK in ovarian cancer medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Background; We aimed to clarify the clinical significance of TOPK (T-lymphokine-activated killer cell-originated protein kinase) expression in ovarian cancer and evaluate the possible effect of TOPK inhibitors, OTS514 and OTS964, on ovarian cancer cells. Methods; TOPK expression was examined by immunohistochemistry using 163 samples with epithelial ovarian cancer (EOC). TOPK protein level and FOXM1 transcriptional […] περισσότερα » Genomic alterations in salivary adenocarcinoma medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Purpose: We sought to identify genomic alterations (GAs) in salivary gland adenocarcinomas, not otherwise specified (NOS), salivary duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca ex PA), and salivary carcinoma, NOS. Experimental design: DNA was extracted from 149 tumors. Comprehensive genomic profiling (CGP) was performed on hybridization-captured adaptor ligation-based libraries of 182 or 315 cancer-related […] περισσότερα » Mutational analysis of cfDNA and single CTCs in MBC medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Purpose: The purpose of this study was to directly compare mutation profiles in multiple single CTCs and cfDNA isolated from the same blood samples taken from patients with metastaic breast cancer (MBC). We aimed to determine whether cell-free DNA would reflect the heterogeneity observed in 40 single CTCs. Experimental design: CTCs were enumerated by Cellsearch. […] περισσότερα » Tumor Microenvironment in Gene Expression Signatures medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα The tumor microenvironment contributes important information in gene expression signatures but may be susceptible to sampling variance. Mesenchymal signatures in particular may be influenced by sampling of non-representative regions with high stromal content. Appropriate pathology quality control is required to ensure reproducibility of gene expression signatures. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Pgw0K via IFTTT […] περισσότερα » CSF-1R and NLC in CLL medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Purpose:Monocytes and their progeny are abundant constituents of the tumor microenvironment in lymphoproliferative disorders, including chronic lymphocytic leukemia (CLL). Monocyte-derived cells, including nurse-like cells (NLC) in CLL, promote lymphocyte proliferation and survival, confer resistance to chemotherapy, and are associated with more rapid disease progression. Colony-stimulating factor-1 receptor (CSF-1R) regulates the homeostatic survival of tissue-resident macrophages. […] περισσότερα » Past participle formation in specific language impairment. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα CONCLUSIONS & IMPLICATIONS: In contrast to earlier findings, the present results demonstrate that regular participle formation is problematic for German children with SLI. PMID: 27321811 [PubMed – as supplied by publisher] (Source: International Journal of Language and Communication Disorders) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28NGaCL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete […] περισσότερα » Oxford Handbook of Anaesthesia, 4th ed. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα No abstract available from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/28Rykvb via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα » The Biomechanical Effects of Resuscitation Colloids on the Compromised Lung Endothelial Glycocalyx. medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα BACKGROUND: The endothelial glycocalyx is an important component of the vascular permeability barrier, forming a scaffold that allows serum proteins to create a gel-like layer on the endothelial surface and transmitting mechanosensing and mechanotransduction information that influences permeability. During acute inflammation, the glycocalyx is degraded, changing how it interacts with serum proteins and colloids used […] περισσότερα » First case of Currarino Syndrome and Trimethylaminuria: two rare diseases for a complex clinical presentation otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/28X47ao via IFTTT http://ift.tt/28RoF7N περισσότερα » First case of Currarino Syndrome and Trimethylaminuria: two rare diseases for a complex clinical presentation Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/28X47ao via IFTTT περισσότερα » No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph-angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two-stage analysis: First, 381 polymorphisms from 30 genes (eight Vascular Endothelial Growth Factor (VEGF) and 22 Matrix Metalloproteinase [MMP] genes) […] περισσότερα » Genetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract RAD51B plays a central role in homologous recombinational repair (HRR) of DNA double-strand breaks (DSBs), which is important to prevent genomic instability, a hallmark of cancer. Recent studies suggested that common genetic variants of RAD51B may contribute to cancer susceptibility. In this study, we aimed to investigate whether potentially functional variants within miRNA-binding sites […] περισσότερα » Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract The carboxyl terminus of the Hsc70-interacting protein (CHIP) is considered to induce the ubiquitination and degradation of several oncogenic proteins, and play a role in the inhibition of tumor progression and invasion under experimental conditions. However, the impact of CHIP expression on the prognosis of breast cancer patients has not yet been established. In […] περισσότερα » Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain […] περισσότερα » RRM1 *151A>T, RRM1 -756T>C, and RRM1 -585T>Gis associated with increased susceptibility of lung cancer in Chinese patients alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract Ribonucleotide reductase M1 (RRM1) is a crucial gene in DNA repair. Recent studies have shown that RRM1 expression can be a powerful predictor of survival or chemotherapy sensitivity in patients presenting with carcinomas who are treated with adjuvant gemcitabine-based chemotherapy including lung cancer. However, the relationship between the single nucleotide polymorphisms (SNP) of RRM1 […] περισσότερα » TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract Transforming acidic coiled-coil protein 2 (TACC2) belongs to TACC family proteins and involved in a variety of cellular processes through interactions with some molecules involved in centrosomes/microtubules dynamics. Mounting evidence suggests that TACCs is implicated in the progression of some human malignancies, but significance of TACC2 protein in breast carcinoma is still unknown. Therefore, […] περισσότερα » Closer adherence to cancer prevention recommendations more effective alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα As part of their cancer prevention efforts, leading cancer organisations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) have published recommendations on diet and physical… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/28OUZUe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 περισσότερα » Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear. Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we […] περισσότερα » Patient-related outcome measures with implant therapy after 5 years alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract Objective To analyze patients' perception of implant therapy in partial edentulism, after 5 years with implant-supported reconstructions. Material and methods Patients who received dental implants at the National Dental Centre, Singapore 3–9 years earlier (mean: 5.2 years) were invited to participate in the study. Responders were examined clinically, and asked to answer a questionnaire […] περισσότερα » Five-year retrospective study on success, survival and incidence of complications of single crowns supported by dental implants alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα Abstract Objective To determine the survival and the incidence of biologic and technical complications of implant-supported single crowns after 5 years of function. Material and methods Patients treated with dental implants at the National Dental Centre, Singapore, from 2006 to 2010 were recruited from the Implant Registry and evaluated by two clinicians. One hundred and […] περισσότερα » Anatomy Pathology Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Anatomy Pathology via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your compu… περισσότερα » Surgical and Radiologic Anatomy Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Surgical and Radiologic Anatomy *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your c… περισσότερα » Indian Journal of Radiology and Imaging Alexandros G. SfakianakisστοΑπεικονιστικήΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Indian Journal of Radiology and Imaging : 2016 - 26(2) *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to yo… περισσότερα » Nanomaterials, Vol. 6, Pages 122: Plasma Nanoengineering and Nanofabrication Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα With the recent advances in nanotechnology, plasma nanofabrication has become an exciting new niche because plasma-based approaches can deliver unique structures at the nanoscale that cannot be achieved by other techniques and/or in a more economical and environmentally friendly manner.[…] from #Medicine via ola Kala on Inoreader http://ift.tt/28RzmYq via IFTTT περισσότερα » Highly educated men are more likely to be diagnosed with a brain tumour Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα A new study from Karolinska Institutet published in The Journal of Epidemiology and Community Health shows that people of a higher socioeconomic position are more commonly diagnosed with glioma, the most common form of adult brain tumour. The results are particularly salient for men. The paper is based on a large population study including 4.3 million people born in Sweden between 1911 and 1961 who studied during the period from 1993 to 2010. The results show a correlation between socioeconomic position and the likelihood of being diagnosed with glioma that although found in both … περισσότερα » Returning to KI with the bigger picture Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα During his postdoc period at Harvard University, Ninib Baryawno has learnt to think big, and when he returns to KI next year, he'll be bringing with him a broader view of research. It might sound mad for someone to switch to another research field when about to do their postdoc period overseas. For Ninib Baryawno, however, it was a deliberate choice. As a doctoral student, he studied medulloblastoma, a form of cancer that creates brain tumours in children and that scientists now believe to be a stem cell disease. Ninib knew even then that he wanted to learn more about stem cells, a… περισσότερα » Low-Cost Simulation to Teach Anesthetists' Non-Technical Skills in Rwanda. AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα BACKGROUND: Safe anesthesia care is challenging in developing countries where there are shortages of personnel, drugs, equipment, and training. Anesthetists' Non-technical Skills (ANTS)-task management, team working, situation awareness, and decision making-are difficult to practice well in this context. Cesarean delivery is the most common surgical procedure in sub-Saharan Africa. This pilot study investigates whether a low-cost simulation model, with good psychological fidelity, can be used effectively to teach ANTS during cesarean delivery in Rwanda. METHODS: Study participants w… περισσότερα » Impact of On-Bypass Red Blood Cell Transfusion on Severe Postoperative Morbidity or Mortality in Children. AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα BACKGROUND: Children undergoing cardiac surgery are frequently exposed to red blood cell (RBC) transfusions mainly in the case of hemorrhage or low oxygen transport. However, in this population, RBCs are sometimes added to the cardiopulmonary bypass (CPB) priming solution to maintain a predefined hematocrit on bypass. In this study, we investigated the impact of RBCs added to the CPB on severe postoperative morbidity or mortality. METHODS: This retrospective cohort study was conducted between 2006 and 2012 in a tertiary care level, children's hospital. Children receiving red cells on… περισσότερα » Impact of On-Bypass Red Blood Cell Transfusion on Severe Postoperative Morbidity or Mortality in Children. Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα BACKGROUND: Children undergoing cardiac surgery are frequently exposed to red blood cell (RBC) transfusions mainly in the case of hemorrhage or low oxygen transport. However, in this population, RBCs are sometimes added to the cardiopulmonary bypass (CPB) priming solution to maintain a predefined hematocrit on bypass. In this study, we investigated the impact of RBCs added to the CPB on severe postoperative morbidity or mortality. METHODS: This retrospective cohort study was conducted between 2006 and 2012 in a tertiary care level, children's hospital. Children receiving red cells on… περισσότερα » TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Abstract Transforming acidic coiled-coil protein 2 (TACC2) belongs to TACC family proteins and involved in a variety of cellular processes through interactions with some molecules involved in centrosomes/microtubules dynamics. Mounting evidence suggests that TACCs is implicated in the progression of some human malignancies, but significance of TACC2 protein in breast carcinoma is still unknown. Therefore, […] περισσότερα » Closer adherence to cancer prevention recommendations more effective sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα As part of their cancer prevention efforts, leading cancer organisations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) have published recommendations on diet and physical… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28OUZUe via IFTTT περισσότερα » What Explains Differences in Availability of Community Health-Related Services for Seniors in the United States? sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Objective: This study analyzes the links between planning, the built environment, and availability of health-related community services across U.S. urban and rural communities. Method: We analyze the first national survey of health-related community services for seniors (2010 Maturing of America), covering 1,459 U.S. cities and counties. We tested the influence of morbidity (diabetes and obesity), […] περισσότερα » Off-label and unlicensed medicines to hospitalised children in Norway Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives The aim of this study was to investigate the use of off-label (OL) and unlicensed (UL) medicines to hospitalised children in Norway, to add to the current knowledge on use of medicines in this vulnerable patient group. Methods The study was performed as a cross-sectional prospective study. Medication was classified as on- or off-label based on the comparison with the SmPC regarding age, indication, dosage, route of administration and handling of the product. UL products were classified as imported or pharmacy produced. Key findings More than 90% of children r… περισσότερα » Safe implementation of standard concentration infusions in paediatric intensive care Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objective To evaluate safety, following introduction of standard concentrations of morphine infusions in paediatric critical care. Methods *Implementation*: A multidisciplinary team was convened, and several workstreams designated, including derivation of concentrations, manufacturing, supply, prescribing, administration using smart pump technology, training and evaluation. *Safety Evaluation*: Retrieval of all existing data on medication errors linked to morphine use using our hospital incident reporting system and risk assessment of errors in relation to standard conc… περισσότερα » Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives To investigate the apoptosis-inducing effect and underlying mechanisms of luteolin in cholangiocarcinoma (CCA) cells. Methods Cell viability was determined by sulphorhodamine B. Apoptosis was detected using acridine orange/ethidium bromide dye staining and annexin V/PI staining followed by flow cytometry. The effect of luteolin on the oxidative status of CCA cells was evaluated by measuring intracellular reactive oxygen species (ROS) levels using the dihydroethidium method and quantifying glutathione levels. The mitochondria transmembrane potential (ΔΨm) was … περισσότερα » Synergistic analgesic effect of propofol–alfentanil combination through detecting the inhibition of cAMP signal pathway Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objective The study aims to investigate the possible mechanism of the synergistic analgesic effect of propofol–alfentanil combination. Methods The synergistic analgesic effects of propofol–alfentanil combination in Sprague–Dawley (SD) rats were analysed through the von Frey test. Then, we examined the activity of phospholipase C (PLC) and the intracellular levels of Ca2+ and adenosine 3′, 5′cyclic monophosphate (cAMP) in primary neuronal cells of fetal SD rats. We detected the intracellular Ca2+ concentration by fluorescence and flow cytometry. The PLC activity of the pr… περισσότερα » Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα Abstract Objectives Carvacrol, a monoterpene widely present in nature, is commonly used in the food industry and in cosmetics, besides to possess a plethora of pharmacological properties, among these also *in vitro* vasorelaxing effects and *in vivo* hypotensive responses. Although in rat aortic rings carvacrol evoked a vasodilatation both in the presence and in the absence of endothelium, in preparations with intact endothelial layer its vasoactive response markedly improved. Methods This study aimed at investigating the mechanism of action responsible for the endothelial compo… περισσότερα » Thyroid Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* thyroid2 via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and … περισσότερα » Cephalalgia Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cephalalgia RSS feed – Preview Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer an… περισσότερα » Thyroid Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* thyroid via Alexandros G.Sfakianakis on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your co… περισσότερα » Spine Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Spine via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can… περισσότερα » Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic post-traumatic neuropathic pain in the ankle and foot: the PREPLANS study Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 2 ώρες Introduction Peripheral neuropathic pain (PNP) associated with trauma is often refractory to treatment. Administration of local anaesthetics (LA) and steroids around injured nerves has been proposed as an option for patients unresponsive to conventional treatments for refractory PNP following trauma. There is insufficient evidence to support a large, potentially expensive, full-scale randomised controlled trial (RCT) that involves comparison of effects of perineural steroids and LA against LA or saline injections on analgesia, physical and psychological functioning, and quality … περισσότερα » What Explains Differences in Availability of Community Health-Related Services for Seniors in the United States? medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Objective: This study analyzes the links between planning, the built environment, and availability of health-related community services across U.S. urban and rural communities. Method: We analyze the first national survey of health-related community services for seniors (2010 Maturing of America), covering 1,459 U.S. cities and counties. We tested the influence of morbidity (diabetes and obesity), […] περισσότερα » Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Uptake and integration of exogenous DNA into the bacterial genome play an important role in the evolution of the pathogen Helicobacter pylori . Here, the authors describe a bimodal pattern of chromosomal integration and show how restriction-modification systems limit the import of heterologous DNA. Nature Communications doi: 10.1038/ncomms11995 Authors: Sebastian Bubendorfer, Juliane Krebes, Ines […] περισσότερα » ASC filament formation serves as a signal amplification mechanism for inflammasomes medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome regulatory pathways. Nature Communications doi: 10.1038/ncomms11929 Authors: Mathias S. Dick, Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller, Petr Broz from #Medicine-SfakianakisAlexandros […] περισσότερα » Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal amplifications as a driving force in progression. Nature Communications doi: 10.1038/ncomms12008 Authors: Peter Ulz, Jelena Belic, […] περισσότερα » Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling. Nature Communications doi: 10.1038/ncomms12047 Authors: Fatemeh Mirzamohammadi, Garyfallia […] περισσότερα » The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article The activation of bacterial mechanosensitive channels is still not fully understood. Here, Bavi et al . show that the N-terminal helix of MscL dynamically couples membrane tension to channel gating, suggesting a conserved mechanism underlying the mechanosensitivity of ion channels of higher organisms. Nature Communications doi: 10.1038/ncomms11984 Authors: Navid Bavi, D. Marien Cortes, Charles […] περισσότερα » Experimental demonstration of the microscopic origin of circular dichroism in two-dimensional metamaterials medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article The effect of Ohmic dissipation in two-dimensional chiral materials has never been experimentally verified. Here, Khanikaev et al . demonstrate that the circular dichroism in a nanostructured metasurface occurs due to handedness-dependent Ohmic heating. Nature Communications doi: 10.1038/ncomms12045 Authors: A. B. Khanikaev, N. Arju, Z. Fan, D. Purtseladze, F. Lu, J. Lee, P. Sarriugarte, […] περισσότερα » Demographic routes to variability and regulation in bird populations medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Why does population variability differ? Sæther et al . show that the magnitude of temporal variation of avian population fluctuations is mainly determined by environmental fluctuations affecting recruitment, whereas regulation of mean population size occurs through density-dependent mortality. Nature Communications doi: 10.1038/ncomms12001 Authors: Bernt-Erik Sæther, Vidar Grøtan, Steinar Engen, Tim Coulson, Peter R. Grant, […] περισσότερα » Influence of orbital symmetry on diffraction imaging with rescattering electron wave packets medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article Laser-induced electron diffraction possesses sufficient resolution to resolve nuclear dynamics in molecules, but imaging was thought to depend on the orbital symmetries for the backscattering electrons. Here, the authors image the structure of randomly oriented O 2 and C 2 H 2 molecules and prove the contrary. Nature Communications doi: 10.1038/ncomms11922 Authors: M. G. […] περισσότερα » The biogeography of red snow microbiomes and their role in melting arctic glaciers medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες Article The Arctic is melting at an unprecedented rate and key drivers are changes in snow and ice albedo. Here, the authors show that red pigmented snow algae play a crucial role in decreasing surface albedo and their patterns for diversity, pigmentation, and consequently albedo, are ubiquitous across the Arctic. Nature Communications doi: 10.1038/ncomms11968 Authors: […]from Medicine by Alexandros G. Sfakianakis http://ift.tt/28TDi9r
via IFTTT
Myelin Oligodendrocyte Glycoprotein induces incomplete tolerance of CD4+ T cells specific for both a myelin and a neuronal self antigen in mice
T-cell polyspecificity, predicting that individual T cells recognize a continuum of related ligands, implies that multiple antigens can tolerize T cells specific for a given self-antigen. We previously showed in C57BL/6 mice that part of the CD4+ T-cell repertoire specific for myelin oligodendrocyte glycoprotein (MOG) 35–55 also recognizes the neuronal antigen neurofilament medium (NF-M) 15–35. Such bi-specific CD4+ T cells are frequent and produce inflammatory cytokines after stimulation. Since T cells recognizing two self-antigens would be expected to be tolerized more efficiently, this finding prompted us to study how polyspecificity impacts tolerance. We found that similar to MOG, NF-M is expressed in the thymus by medullary thymic epithelial cells, a tolerogenic population. Nevertheless, the frequency, phenotype, and capacity to transfer experimental encephalomyelitis (EAE) of MOG35-55-reactive CD4+ T cells were increased in MOG-deficient but not in NF-M-deficient mice. We found that presentation of NF-M15-35 by I-Ab on dendritic cells is of short duration, suggesting unstable MHC class II binding. Consistently, introducing an MHC-anchoring residue into NF-M15-35 (NF-M15-35T20Y) increased its immunogenicity, activating a repertoire able to induce EAE. Our results show that in C57BL/6 mice bi-specific encephalitogenic T cells manage to escape tolerization due to inefficient exposure to two self-antigens.
This article is protected by copyright. All rights reserved
from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/28Px87g
Proteomic analysis of docetaxel resistance in human nasopharyngeal carcinoma cells using the two-dimensional gel electrophoresis method.
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months. Two-dimensional gel electrophoresis and ESI-Q-TOF-MS were used to compare the differential expression of docetaxel-resistance-associated proteins between human NPC CNE-2 cells and docetaxel-resistant CNE-2R cells. As a result, 24 differentially expressed proteins were identified, including 11 proteins with increased expression and 13 proteins with decreased expression. These proteins function in diverse biological processes such as metabolism, signal transduction, calcium ion binding, immune response, proteolysis, and so on. Among these, [alpha]-enolase (ENO1), significantly upregulated in CNE-2R, was selected for detailed analysis. Inhibition of ENO1 by shRNA restored CNE-2R cells' sensitivity to docetaxel. Moreover, overexpression of ENO1 could facilitate the development of acquired resistance of docetaxel in CNE-2 cells. Western blot and reverse-transcription PCR data of clinical samples confirmed that [alpha]-enolase was upregulated in docetaxel-resistant human NPC tissues. Finding such proteins might improve interpretation of the molecular mechanisms leading to the acquisition of docetaxel chemoresistance. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
from Cancer via xlomafota13 on Inoreader http://ift.tt/28OIyKy
via IFTTT
http://ift.tt/28XiHys
from Cancer via xlomafota13 on Inoreader http://ift.tt/28OIyKy
via IFTTT
http://ift.tt/28XiHys
Paralleled comparison of vectors for the generation of CAR-T cells.
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into T-lymphocytes, equipping CAR-modified T cells with a property of recognizing and attacking antigen-expressing tumor cells in a major histocompatibility complex-independent manner. Here, we summarize the gene-transfer vectors commonly used in the generation of CAR-T cell, including retrovirus vectors, lentivirus vectors, the transposon/transposase system, the plasmid-based system, and the messenger RNA electroporation system. The following aspects were compared in parallel: efficiency of gene transfer, the integration methods in the modified T cells, foreground of scale-up production, and application and development in clinical trials. These aspects should be taken into account to generate the optimal CAR-gene vector that may be suitable for future clinical application. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
from Cancer via xlomafota13 on Inoreader http://ift.tt/28X1C7W
via IFTTT
http://ift.tt/28RvuGk
from Cancer via xlomafota13 on Inoreader http://ift.tt/28X1C7W
via IFTTT
http://ift.tt/28RvuGk
Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types
Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear.
Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated clonal diversity of B-cell infiltrates through calculating B-cell receptor (BCR) repertoire sequence diversity. All statistical tests were two-sided.
Results: High expression of T-cell and B-cell signatures predicted improved overall survival across many tumor types including breast, lung, and melanoma (breast CD8_T_Cells hazard ratio [HR] = 0.36, 95% confidence interval [CI] = 0.16 to 0.81, P = .01; lung adenocarcinoma B_Cell_60gene HR = 0.71, 95% CI = 0.58 to 0.87, P = 7.80E-04; melanoma LCK HR = 0.86, 95% CI = 0.79 to 0.94, P = 6.75E-04). Macrophage signatures predicted worse survival in GBM, as did B-cell signatures in renal tumors (Glioblastoma Multiforme [GBM]: macrophages HR = 1.62, 95% CI = 1.17 to 2.26, P = .004; renal: B_Cell_60gene HR = 1.17, 95% CI = 1.04 to 1.32, P = .009). BCR diversity was associated with survival beyond gene segment expression in melanoma (HR = 2.67, 95% CI = 1.32 to 5.40, P = .02) and renal cell carcinoma (HR = 0.36, 95% CI = 0.15 to 0.87, P = .006).
Conclusions: These data support existing studies suggesting that in diverse tissue types, heterogeneous immune infiltrates are present and typically portend an improved prognosis. In some tumor types, BCR diversity was also associated with survival. Quantitative genomic signatures of immune cells warrant further testing as prognostic markers and potential biomarkers of response to cancer immunotherapy.
from Melanoma via xlomafota13 on Inoreader http://ift.tt/28RgWX4
Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated clonal diversity of B-cell infiltrates through calculating B-cell receptor (BCR) repertoire sequence diversity. All statistical tests were two-sided.
Results: High expression of T-cell and B-cell signatures predicted improved overall survival across many tumor types including breast, lung, and melanoma (breast CD8_T_Cells hazard ratio [HR] = 0.36, 95% confidence interval [CI] = 0.16 to 0.81, P = .01; lung adenocarcinoma B_Cell_60gene HR = 0.71, 95% CI = 0.58 to 0.87, P = 7.80E-04; melanoma LCK HR = 0.86, 95% CI = 0.79 to 0.94, P = 6.75E-04). Macrophage signatures predicted worse survival in GBM, as did B-cell signatures in renal tumors (Glioblastoma Multiforme [GBM]: macrophages HR = 1.62, 95% CI = 1.17 to 2.26, P = .004; renal: B_Cell_60gene HR = 1.17, 95% CI = 1.04 to 1.32, P = .009). BCR diversity was associated with survival beyond gene segment expression in melanoma (HR = 2.67, 95% CI = 1.32 to 5.40, P = .02) and renal cell carcinoma (HR = 0.36, 95% CI = 0.15 to 0.87, P = .006).
Conclusions: These data support existing studies suggesting that in diverse tissue types, heterogeneous immune infiltrates are present and typically portend an improved prognosis. In some tumor types, BCR diversity was also associated with survival. Quantitative genomic signatures of immune cells warrant further testing as prognostic markers and potential biomarkers of response to cancer immunotherapy.
from Melanoma via xlomafota13 on Inoreader http://ift.tt/28RgWX4
Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types
Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear.
Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated clonal diversity of B-cell infiltrates through calculating B-cell receptor (BCR) repertoire sequence diversity. All statistical tests were two-sided.
Results: High expression of T-cell and B-cell signatures predicted improved overall survival across many tumor types including breast, lung, and melanoma (breast CD8_T_Cells hazard ratio [HR] = 0.36, 95% confidence interval [CI] = 0.16 to 0.81, P = .01; lung adenocarcinoma B_Cell_60gene HR = 0.71, 95% CI = 0.58 to 0.87, P = 7.80E-04; melanoma LCK HR = 0.86, 95% CI = 0.79 to 0.94, P = 6.75E-04). Macrophage signatures predicted worse survival in GBM, as did B-cell signatures in renal tumors (Glioblastoma Multiforme [GBM]: macrophages HR = 1.62, 95% CI = 1.17 to 2.26, P = .004; renal: B_Cell_60gene HR = 1.17, 95% CI = 1.04 to 1.32, P = .009). BCR diversity was associated with survival beyond gene segment expression in melanoma (HR = 2.67, 95% CI = 1.32 to 5.40, P = .02) and renal cell carcinoma (HR = 0.36, 95% CI = 0.15 to 0.87, P = .006).
Conclusions: These data support existing studies suggesting that in diverse tissue types, heterogeneous immune infiltrates are present and typically portend an improved prognosis. In some tumor types, BCR diversity was also associated with survival. Quantitative genomic signatures of immune cells warrant further testing as prognostic markers and potential biomarkers of response to cancer immunotherapy.
from Melanoma via xlomafota13 on Inoreader http://ift.tt/28RgWX4
Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated clonal diversity of B-cell infiltrates through calculating B-cell receptor (BCR) repertoire sequence diversity. All statistical tests were two-sided.
Results: High expression of T-cell and B-cell signatures predicted improved overall survival across many tumor types including breast, lung, and melanoma (breast CD8_T_Cells hazard ratio [HR] = 0.36, 95% confidence interval [CI] = 0.16 to 0.81, P = .01; lung adenocarcinoma B_Cell_60gene HR = 0.71, 95% CI = 0.58 to 0.87, P = 7.80E-04; melanoma LCK HR = 0.86, 95% CI = 0.79 to 0.94, P = 6.75E-04). Macrophage signatures predicted worse survival in GBM, as did B-cell signatures in renal tumors (Glioblastoma Multiforme [GBM]: macrophages HR = 1.62, 95% CI = 1.17 to 2.26, P = .004; renal: B_Cell_60gene HR = 1.17, 95% CI = 1.04 to 1.32, P = .009). BCR diversity was associated with survival beyond gene segment expression in melanoma (HR = 2.67, 95% CI = 1.32 to 5.40, P = .02) and renal cell carcinoma (HR = 0.36, 95% CI = 0.15 to 0.87, P = .006).
Conclusions: These data support existing studies suggesting that in diverse tissue types, heterogeneous immune infiltrates are present and typically portend an improved prognosis. In some tumor types, BCR diversity was also associated with survival. Quantitative genomic signatures of immune cells warrant further testing as prognostic markers and potential biomarkers of response to cancer immunotherapy.
from Melanoma via xlomafota13 on Inoreader http://ift.tt/28RgWX4
Orbital Recurrence of Ethmoid Sinus Malignant Meningioma: Case Study and Literature Review.
The authors describe a case of a recurrent World Health Organization grade III extradural, sinonasal meningioma that presented with epiphoria. Primary extradural meningiomas are rare, comprising only 1% to 2% of all meningiomas.1 These tumors are diagnosed and graded histologically according to the World Health Organization criteria.2 Grade III tumors are very malignant with high recurrence and death rates.3 This case highlights the rarity of sinonasal tract meningiomas involving the orbit. In addition, it shows the poor prognosis of such malignant disease and the need for a multidisciplinary approach. Collection and evaluation of protected patient health information for this report was in compliance with the Health Insurance Portability and Accountability Act and approved by the Institutional Review Board of Northwestern University Feinberg School of Medicine. Research adhered to the tenets of the Declaration of Helsinki. (C) 2016 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.
from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XenPz
via IFTTT
from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28XenPz
via IFTTT
Malar Reconstruction Using Y-V Advancement Flaps after Tissue Expansion in Treacher Collins Syndrome
Summary: The Treacher Collins syndrome is characterized by both soft and hard tissue deficiencies. To reconstruct malar hypoplasia with both soft and hard tissues, we designed a new method using cartilage grafts, Y-V advancement flaps, and Z plasty with tissue expansion.from Aesthetics via xlomafota13 on Inoreader http://ift.tt/1tbJ4JF
Color Atlas and Synopsis of Pediatric Dermatology, 3rd edn. Sandipan Dhar, ed. Delhi: Jaypee Brothers Medical Publishers, 2015. ISBN: 978-935-152632-2. Price £116.
from Dermatology via xlomafota13 on Inoreader http://ift.tt/28QD84v
Sequential incremental doses of bisacodyl increase the diagnostic accuracy of colonic manometry
Abstract
Background
Colonic manometry is the standard diagnostic modality for evaluating colonic motility in children. Intraluminal bisacodyl is routinely used to trigger high-amplitude propagating contractions (HAPCs), a feature of normal colonic motility. Usually, only a single dose (0.2 mg/kg) is suggested. We retrospectively explored whether the use of an additional higher (0.4 mg/kg) dose of bisacodyl increases the yield of colonic manometry.
Methods
In 103 children (median age: 8.8 years, range 3.2–15.7 years) with a diagnosis of slow transit constipation, colonic motility was recorded for 1 h before and 1 h after each of two incremental doses of bisacodyl (low, L, dose: 0.2 mg/kg, max 10 mg; high, H, dose: 0.4 mg/kg, max 20 mg) and the characteristics of HAPCs analyzed.
Key Results
High-amplitude propagating contractions were seen in 85 children. H dose significantly increased the proportion of patients with fully propagated HAPCs (H dose: 57/103 [55%], L dose: 27/103 [26%], p < 0.001), paralleling the significant decrease in the proportion with partially propagated HAPCs (H dose: 29/103 [28%], L dose: 47/103 [46%], p < 0.01). Mean HAPC number significantly increased throughout the colon at H compared to L dose (7.2 ± 5.05 vs 5.6 ± 5.1, p < 0.05). Finally, the proportion of patients with normal pressure wave morphology of HAPCs significantly increased with higher dose (H dose: 55/85 [65%], L dose: 27/85 [32%], p < 0.001).
Conclusions & Interferences
An additional higher dose of bisacodyl during colonic manometry improves colonic neuromuscular function suggesting its use might improve interpretation and decision making in children with slow transit constipation.
We retrospectively explored whether the use of sequential incremental dose of bisacodyl given during the colonic manometry increases the yield of the test. An additional high dose of bisacodyl improves colonic neuromuscular function by increasing the proportion of patients with fully propagated high-amplitude propagating contractions (HAPCs) and their morphology. Our data suggest that the use of sequential incremental dose of bisacodyl during colonic manometry might significantly impact the management of children with refractory slow transit constipation.
from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/28NIslj
Orbital Recurrence of Ethmoid Sinus Malignant Meningioma: Case Study and Literature Review.
The authors describe a case of a recurrent World Health Organization grade III extradural, sinonasal meningioma that presented with epiphoria. Primary extradural meningiomas are rare, comprising only 1% to 2% of all meningiomas.1 These tumors are diagnosed and graded histologically according to the World Health Organization criteria.2 Grade III tumors are very malignant with high recurrence and death rates.3 This case highlights the rarity of sinonasal tract meningiomas involving the orbit. In addition, it shows the poor prognosis of such malignant disease and the need for a multidisciplinary approach. Collection and evaluation of protected patient health information for this report was in compliance with the Health Insurance Portability and Accountability Act and approved by the Institutional Review Board of Northwestern University Feinberg School of Medicine. Research adhered to the tenets of the Declaration of Helsinki. © 2016 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.
from Aesthetics via xlomafota13 on Inoreader http://ift.tt/28XenPz
from Aesthetics via xlomafota13 on Inoreader http://ift.tt/28XenPz
Sequential incremental doses of bisacodyl increase the diagnostic accuracy of colonic manometry
Abstract
Background
Colonic manometry is the standard diagnostic modality for evaluating colonic motility in children. Intraluminal bisacodyl is routinely used to trigger high-amplitude propagating contractions (HAPCs), a feature of normal colonic motility. Usually, only a single dose (0.2 mg/kg) is suggested. We retrospectively explored whether the use of an additional higher (0.4 mg/kg) dose of bisacodyl increases the yield of colonic manometry.
Methods
In 103 children (median age: 8.8 years, range 3.2–15.7 years) with a diagnosis of slow transit constipation, colonic motility was recorded for 1 h before and 1 h after each of two incremental doses of bisacodyl (low, L, dose: 0.2 mg/kg, max 10 mg; high, H, dose: 0.4 mg/kg, max 20 mg) and the characteristics of HAPCs analyzed.
Key Results
High-amplitude propagating contractions were seen in 85 children. H dose significantly increased the proportion of patients with fully propagated HAPCs (H dose: 57/103 [55%], L dose: 27/103 [26%], p < 0.001), paralleling the significant decrease in the proportion with partially propagated HAPCs (H dose: 29/103 [28%], L dose: 47/103 [46%], p < 0.01). Mean HAPC number significantly increased throughout the colon at H compared to L dose (7.2 ± 5.05 vs 5.6 ± 5.1, p < 0.05). Finally, the proportion of patients with normal pressure wave morphology of HAPCs significantly increased with higher dose (H dose: 55/85 [65%], L dose: 27/85 [32%], p < 0.001).
Conclusions & Interferences
An additional higher dose of bisacodyl during colonic manometry improves colonic neuromuscular function suggesting its use might improve interpretation and decision making in children with slow transit constipation.
We retrospectively explored whether the use of sequential incremental dose of bisacodyl given during the colonic manometry increases the yield of the test. An additional high dose of bisacodyl improves colonic neuromuscular function by increasing the proportion of patients with fully propagated high-amplitude propagating contractions (HAPCs) and their morphology. Our data suggest that the use of sequential incremental dose of bisacodyl during colonic manometry might significantly impact the management of children with refractory slow transit constipation.
from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/28NIslj
Low-Dose Carotid Computed Tomography Angiography Using Pure Iterative Reconstruction.
Low-Dose Carotid Computed Tomography Angiography Using Pure Iterative Reconstruction.: Objective: The aim of this study was to assess if a low-dose carotid computed tomography angiography (CTA) performed with pure iterative reconstruction (IR) is comparable to a conventional dose CTA protocol. Methods: Twenty patients were included. Radiation dose was divided into a low-dose acquisition reconstructed with pure IR and a conventional dose acquisition reconstructed with 40% hybrid IR. Dose, image noise, contrast resolution, spatial resolution, and carotid artery stenosis were measured. Results: Mean effective dose was significantly lower for low-dose than conventional dose studies (1.84 versus 3.71 mSv; P
from Imaging via xlomafota13 on Inoreader
via IFTTT
from Imaging via xlomafota13 on Inoreader
via IFTTT
Computed Tomography Imaging of a Hip Prosthesis Using Iterative Model-Based Reconstruction and Orthopaedic Metal Artefact Reduction: A Quantitative Analysis.
Computed Tomography Imaging of a Hip Prosthesis Using Iterative Model-Based Reconstruction and Orthopaedic Metal Artefact Reduction: A Quantitative Analysis.: Objectives: To quantify the combined use of iterative model-based reconstruction (IMR) and orthopaedic metal artefact reduction (O-MAR) in reducing metal artefacts and improving image quality in a total hip arthroplasty phantom. Methods: Scans acquired at several dose levels and kVps were reconstructed with filtered back-projection (FBP), iterative reconstruction (iDose4) and IMR, with and without O-MAR. Computed tomography (CT) numbers, noise levels, signal-to-noise-ratios and contrast-to-noise-ratios were analysed. Results: Iterative model-based reconstruction results in overall improved image quality compared to iDose4 and FBP (P
from Imaging via xlomafota13 on Inoreader
via IFTTT
from Imaging via xlomafota13 on Inoreader
via IFTTT
Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging.
Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging.: Objective: We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI). Methods: A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR images of patients with lung fibrosis; 4D MR ventilation maps were compared with corresponding diagnostic 3D CT images of the patients and 4D CT maps of subjects without impaired lung function (serving as reference). Results: Comparison between the computed patient-specific 4D MR regional ventilation maps and diagnostic CT images shows good correlation in conspicuous regions. Comparison to 4D CT-derived ventilation maps supports the plausibility of the 4D MR maps. Dynamic MRI-based flow-volume loops and spirograms further visualize the free-breathing behavior. Conclusions: The proposed methods allow for 4D MR-based regional analysis of tissue dynamics and ventilation in spontaneous breathing and comparison of patient data. The proposed atlas-based reference coordinate system provides an automated manner of annotating and comparing multimodal lung image data. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
from Imaging via xlomafota13 on Inoreader
via IFTTT
from Imaging via xlomafota13 on Inoreader
via IFTTT
Active Surveillance of Small Renal Masses: A Review on the Role of Imaging With a Focus on Growth Rate.
Active Surveillance of Small Renal Masses: A Review on the Role of Imaging With a Focus on Growth Rate.: Objective: This study aimed to systematically summarize the current literature in the field of active surveillance for small renal masses, with the primary focus being the role of imaging in the primary decision-making and subsequent follow-up. Materials: A systematic review of the electronic databases PubMed and Web of Knowledge was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analysis statement guidelines. Variables were extracted from the data set and included the following: (1) patient demographics, (2) tumor characteristics, and (3) study design. Results: Twenty-one articles studying imaging in active surveillance of small renal masses were selected. Seventy-two percent (15/21) of studies were retrospective; 19% (4/21) were prospective; and 9% (2/21) studies were bidirectional. Mean age of patients was 69 years (range, 57-81 years). A total of 1386 patients were in the study; 59% of patients were men. Mean follow-up was 39 months (range, 18.8-91.5 months). Sixty-seven percent of masses discussed in this review were followed up using more than one imaging modality; 19% consistently used computed tomography for follow-up whereas the remaining 14% did not specify what imaging modality was used. Imaging studies were reviewed by the investigators centrally in 86% (18/21). In 14% of the studies, only imaging report was reviewed. Biopsy was performed in 24% of masses. Mean growth rate for all tumors was 0.27 cm/y (range, 0.06-0.7 cm/y). For studies where growth rate of benign and malignant masses were differentiated, mean growth rate for benign masses was 0.3 cm/y and mean growth rate for malignant masses was 0.35 cm/y. Conclusions: Growth rate is often used as a discriminant in following up a small renal mass in patients undergoing active surveillance. However, there is great variability in growth rate and it alone is not an adequate marker for determining whether the tumor is malignant. Because very few studies specified radiological characteristics of small renal masses, future studies can be done to better characterize masses. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
from Imaging via xlomafota13 on Inoreader
via IFTTT
from Imaging via xlomafota13 on Inoreader
via IFTTT
Renal Cell Carcinoma: Accuracy of Multidetector Computed Tomography in the Assessment of Renal Sinus Fat Invasion.
Renal Cell Carcinoma: Accuracy of Multidetector Computed Tomography in the Assessment of Renal Sinus Fat Invasion.: Purpose: The purpose of this study was to evaluate the accuracy of multidetector computed tomography (MDCT) in the preoperative assessment of renal sinus fat invasion (RSFI) in patients with renal cell carcinoma (RCC) and to assess imaging features that improve detection of RSFI on CT. Methods: This is a single-institution retrospective review of 53 consecutive patients with histologically proven RCC who underwent triple-phase preoperative contrast MDCT prior to partial or radical nephrectomy. Two experienced radiologists (R1 and R2), blinded to the final histology result, independently reviewed the preoperative MDCT studies to assess for RSFI. Histopathology was used as the gold standard for the presence of RSFI. Results: Of 55 surgically resected RCCs that were evaluated with contrast-enhanced MDCT, 34.5% (19/55) of RCCs had RSFI on final histopathology. Multidetector CT demonstrated high sensitivity (R1, 100%; R2, 93.7%) for the detection of RSFI, but a low positive predictive value (R1, 40%; R2, 53%) and specificity (R1, 38.4%; R2, 66.6%). Interreader agreement for RSFI was moderate ([kappa] = 0.56). Renal tumors were significantly larger in cases with RSFI (6.3 +/- 3.219 cm) than tumors without RSFI (4.1 +/- 2.9 cm) (P = 0.0275). Renal sinus fat invasion was more commonly associated to an irregular tumor margin at the tumor renal sinus fat interface (P
from Imaging via xlomafota13 on Inoreader
via IFTTT
from Imaging via xlomafota13 on Inoreader
via IFTTT
Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions.
Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions.: We present a case of a 30-year-old woman who, while undergoing infertility evaluation, was found to have a large cystic cervical mass, shown to be cystic cervicitis on cervical cone biopsy. Differential diagnosis for benign cystic cervical lesions includes Nabothian cysts, tunnel cluster, endocervical hyperplasia, and cervicitis, whereas cystic cervical malignancies include adenocarcinoma and adenoma malignum. While it is crucial to differentiate benign from malignant lesions, imaging characteristics often overlap and may not provide a specific diagnosis. In difficult cases, definitive diagnosis should be based on clinical presentation and cervical biopsy. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
from Imaging via xlomafota13 on Inoreader
via IFTTT
from Imaging via xlomafota13 on Inoreader
via IFTTT
Filter by category:
22
3
12
from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28YP282
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου