Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy: AbstractBackgroundThis study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning proton arc (SPArc) therapy for left-sided whole breast radiotherapy (WBRT) to further reduce radiation dose to healthy tissue and mitigate the probability of normal tissue complications compared to conventional intensity modulated proton therapy (IMPT).MethodsEight...
09:24
Endobronchial Ultrasound Elastography for Differentiating Benign and Malignant Lymph Nodes: Background: Endobronchial ultrasound elastography that provides information on tissue stiffness may help distinguish malignant from benign mediastinal and hilar lymph nodes. Objectives: In this prospective trial, we assessed the diagnostic value of elastographic images and the interobserver agreement in its evaluation. Method: Elastographic images from 77 lymph nodes in 65 patients were reviewed by 3 pneumologists....
09:22
Calvarial Melanotic Neuroectodermal Tumor of Infancy with Rhabdomyosarcomatous differentiation—A Rare Case: Publication date: January 2021Source: World Neurosurgery, Volume 145Author(s): Jeyaseelan Nadarajah, Ajay Garg, Sandeep Bohara, Kanwaljeet Garg, Leve Joseph Devaranjan Sebastian, Vaishali Suri, Sameer Bakhshi, Manmohan SinghFigures (8)Show all figuresTables (1)Table 1World NeurosurgeryVolume 145, January 2021, Pages 134-141Case ReportCalvarial Melanotic Neuroectodermal Tumor of Infancy with...
09:22
Middle segment-preserving pancreatectomy for multifocal pancreatic ductal adenocarcinoma located in the head and tail of the pancreas: a case report: AbstractA 77-year-old woman with a solitary existence was referred to our hospital for the treatment of pancreatic tumors. Computed tomography revealed an 18-mm mass in the pancreatic head that had invaded the right side of the superior mesenteric vein (SMV) and a 32-mm mass in the pancreatic tail. We performed middle segment-preserving pancreatectomy...
09:20
Massive bleeding of a jejunal gastrointestinal stromal tumour: a rare case of a life-threatening presentation: AbstractA jejunal gastrointestinal stromal tumour (GIST) is a rare neoplasm of the gastrointestinal tract. Massive bleeding due to a jejunal GIST is a diagnostic challenge and could present as a life-threatening situation needing urgent intervention. A 54-year-old woman presented with episodes of melaena and haematochezia for the previous 3 days. An oesophagoduodenoscopy was inconclusive....
09:19
Chronic pancreatitis with ductal stones in the pancreatic head treated by surgery: a case report: AbstractPancreatic duct stones are direct sequelae of chronic pancreatitis (CP) and can occur in ∼50% of patients. Selection of the appropriate treatment method for pancreatic duct stones depends on location, size and number of stones. We present a patient with upper abdominal pain and weight loss for the previous 3 months. Diagnostic workup detected a chronic inflammation of the pancreas with stone...
09:19
Selenium intracanal dressing: effects on the periapical immune response: AbstractObjectivesTo evaluate the selenium (Se) behavior when used as an endodontic dressing in teeth with pulp necrosis. Additionally, its effects was also compared with the calcium hydroxide (C.H.), which is used globally as a root canal dressing, and the combination of the C.H. with Se (C.H. + Se). Materials and methodsThe sample consisted of 60 patients requiring endodontic treatment who were divided...
09:18
Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California: AbstractBackground: Incidence rates of thyroid cancer in children and young adults (age 0–19 years) have nearly doubled over a recent 15-year period in the United States. Children with thyroid cancer may require long-term therapy and surveillance and are at greater risk for second primary malignancies. High-dose exposure to ionizing radiation is the only known nongenetic risk factor;...
09:18
Isolation of Cardiomyocytes from Fixed Hearts for Immunocytochemistry and Ploidy Analysis: The goal of this work is to develop a method to reproducibly isolate cardiomyocytes from the adult heart and measure DNA content and nucleation.
09:16
Evaluation of root and canal morphology of maxillary permanent first molars in an Emirati population; a cone-beam computed tomography study: AbstractBackgroundThe aim of this study was to analyze the root and canal morphology of the maxillary permanent first molars in an Emirati population using cone-beam computed tomography (CBCT). MethodsTwo hundred and sixty-one CBCT scans were acquired. The data were extracted and anonymized to remove all patient identifiers. Two observers...
09:16
Navigated Antral Bone Expansion (NABE): a prospective study on 35 patients with 4 months of follow-up post implant loading: AbstractBackgroundThe insertion of dental implants in the atrophic posterior maxilla can be a challenge. One option is to modify the residual native bone in preparation for proper, prosthetically-driven implant placement. The procedure presented in this study is called Navigated Antral Bone Expansion (N.A.B.E). This procedure employs the use of a navigation system to plan and...
09:15
Thrombectomy for acute ischemic stroke patients with isolated distal internal carotid artery occlusion: a retrospective observational study: AbstractPurposeAcute stroke patients presenting with a distal internal carotid artery occlusion and patent carotid terminus, allowing for collateral flow via the circle of Willis, may have a more favorable natural history. Therefore, benefit of endovascular treatment (EVT) is less evident. We performed an exploratory analysis of EVT results compared to conservative...
09:15
De novo variant in AMOTL1 in infant with cleft lip and palate, imperforate anus and dysmorphic features: AbstractAMOTL1 belongs to the Motin family of proteins that are involved in organogenesis and tumorigenesis through regulation of cellular migration, tube formation, and angiogenesis. While involvement of all AMOTs in development or suppression of cancers is relatively well described, little is known about the congenital phenotype of pathogenic variants in these genes in humans. Recently, a heterozygous...
09:12
Congenital hiatal hernia segregating with a duplication in 9q22.31q22.32 in two families: AbstractCongenital hiatal hernia (HH) is a rare congenital defect and is often described on a sporadic basis, but familial cases have also been reported. The mechanism of development is not well understood, and to our knowledge no specific genetic factors have been implicated to date. We report on seven individuals from two families with 9q22 duplication, who have variably associated features including congenital...
09:12
Outcome of 45,X fetuses with cystic hygroma: A systematic review: AbstractThis objective of this systematic review was to estimate live birth rate and explore prognostic indicators in fetuses with 45,X karyotype and a posterior cystic hygroma (CH). Electronic databases were searched and studies reporting pregnancy outcomes (termination, spontaneous abortion, demise, or live birth) for fetuses with 45,X karyotype and a CH diagnosed on ultrasound were included. For cases of survival, CH characteristics,...
09:10
Imaging endpoints of intracranial atherosclerosis using vessel wall MR imaging: a systematic review: AbstractPurposeThe vessel wall MR imaging (VWI) literature was systematically reviewed to assess the criteria and measurement methods of VWI-related imaging endpoints for symptomatic intracranial plaque in patients with ischemic events. MethodsPubMed, Scopus, Web of Science, EMBASE, and Cochrane databases were searched up to October 2019. Two independent reviewers extracted data...
09:07
Safety and Efficacy of Tattoo Removal Using a Dual‐Wavelength 1064/532‐nm Picosecond Laser in Patients With Fitzpatrick Skin Type III and IV: Background and ObjectivesTo investigate the safety and efficacy of a dual‐wavelength 1064/532‐nm picosecond‐domain laser for tattoo removal in Vietnamese patients.Study Design/Materials and MethodsThis prospective clinical study enrolled 30 subjects with 52 decorative tattoos treated with up to six treatments of laser removal at intervals of 6–8 weeks. Safety...
09:01
Nicotinamide inhibits melanoma in vitro and in vivo: Francesca Scatozza, Federica Moschella, Daniela D'Arcangelo, Stefania Rossi, Claudio Tabolacci, Claudia Giampietri, Enrico Proietti, Francesco Facchiano & Antonio Facchiano Journal of Experimental & Clinical Cancer Research volume 39, Article number: 211 (2020) Cite this articleMetricsdetailsAbstractBackgroundEven though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues....
09:00
Oral mucositis: the hidden side of cancer therapy: AbstractInflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated with chemotherapy develop mucositis; this percentage rises to about 90% for head and neck cancer patients (HNC) treated with both chemo- and radiotherapy. 19% of the latter will be hospitalized and will experience a delay in antineoplastic treatment for...
08:59
Dose-Response with Stereotactic Body Radiotherapy for Prostate Cancer: A Multi-Institutional Analysis of Prostate-Specific Antigen Kinetics and Biochemical Control: Publication date: Available online 7 October 2020Source: Radiotherapy and OncologyAuthor(s): Rebecca G. Levin-Epstein, Naomi Y. Jiang, Xiaoyan Wang, Shrinivasa K. Upadhyaya, Sean P. Collins, Simeng Suy, Nima Aghdam, Constantine Mantz, Alan J. Katz, Leszek Miszczyk, Aleksandra Napieralska, Agnieszka Namysl-Kaletka, Nicholas Prionas, Hilary...
08:56
Deep learning-enabled MRI-only photon and proton therapy treatment planning for paediatric abdominal tumours: Publication date: Available online 7 October 2020Source: Radiotherapy and OncologyAuthor(s): Mateusz C. Florkow, Filipa Guerreiro, Frank Zijlstra, Enrica Seravalli, Geert O. Janssens, John H. Maduro, Antje C. Knopf, René M. Castelein, Marijn van Stralen, Bas W. Raaymakers, Peter R. SeevinckHighlights•Satisfactory synthetic CT images were derived from planning T1w and T2w MR images.•Deep learning-based...
08:55
Successful treatment of pyopneumothorax secondary to Streptococcus constellatus infection with linezolid: a case report and review of the literature: AbstractBackgroundPyopneumothorax secondary to Streptococcus constellatus infection is a clinically rare event, and few cases have been reported.Case presentationWe report the case of a 55-year-old Han Chinese man with underlying diabetes who presented with fever of 17 days duration. A pulmonary computed tomography scan revealed right-sided massive...
08:50
Determination of the Voice Parameters in Adult Individuals With Rheumatoid Arthritis and the Relation of Voice With Depression and Inflammation: SummaryObjectivesTo assess, through both objective and subjective methods, the complaints of dysphonia among adults with rheumatoid arthritis (RA). The secondary purpose of the study is to determine whether complaints of dysphonia are related to depression and disease activity.Study DesignThis is a prospective cohort study.MethodsEighty subjects (38...
08:48
Evaluation of Voice After Definitive Radiotherapy in Patients of Early Stage Squamous Cell Carcinoma of Larynx (Glottis): A Prospective Observational Study: AbstractPost treatment voice quality is an important consideration in choosing the management option for laryngeal cancer. We assessed voice quality after radiotherapy in patients of early squamous cell carcinoma of glottis comprehensively using Videolaryngostroboscopy (VLS), Grade, Roughness, Breathiness, Asthenia and Strain (GRBAS) scores and...
08:46
Relation of serum hepcidin levels and restless legs syndrome in chronic hemodialysis patients: AbstractBackgroundIron deficiency anemia, pregnancy, and end-stage renal disease (ESRD) are common causes of secondary restless legs syndrome (RLS). Serum ferritin is considered the most specific test associated with the total amount of body iron stores. However, due to the increase of serum ferritin secondary to inflammation in chronic hemodialysis (HD) patients, serum ferritin test results do not fully...
08:45
The effect of intermittent hypoxia and fecal microbiota of OSAS on genes associated with colorectal cancer: AbstractPurposeColorectal cancer (CRC) is one of the common causes of cancer death worldwide. Obstructive sleep apnea syndrome (OSAS), sharing many risk factors in common with CRC, is prevalent among CRC patients. OSAS may promote the CRC development independently but the mechanism is still unknown. Intermittent hypoxia (IH) is one of the characteristics of OSAS, and hypoxia may influence the...
08:43
Characterization and wearability evaluation of a fully portable wrist exoskeleton for unsupervised training after stroke: Chronic hand and wrist impairment are frequently present following stroke and severely limit independence in everyday life. The wrist orientates and stabilizes the hand before and during grasping, and is there...
08:43
Adjuvant Trastuzumab Emtansine (T-DM1) and Concurrent Radiotherapy for Residual Invasive HER2-positive Breast Cancer: Single-center Preliminary Results: Objectives: The treatment of nonmetastatic HER2-positive breast cancer with residual invasive disease using concurrent Trastuzumab emtansine (T-DM1) and radiotherapy appears to be an effective option. Our aim was to evaluate the acute side effects of this treatment regime. Methods: Fourteen patients were treated between March 2019 and April...
08:42
Expression status of PD‐L1 and B7‐H3 in mesothelioma: Mesothelioma is a rare, aggressive malignancy with poor outcome, and has limited treatment options. The aim of this study was to perform a comprehensive analysis of programmed death ligand 1 (PD‐L1) and B7 homolog 3 (B7‐H3) expression in mesothelioma. We investigated the protein expression of PD‐L1 and B7‐H3 and their potential correlation with histological subtype, which might help to develop new therapies targeting these immune checkpoint molecules....
08:41
Simulation of proximal catheter occlusion and design of a shunt tap aspiration system: AbstractPurposeTotal and partial proximal catheter occlusions are well-known complications of ventriculoperitoneal shunts (VPS). When this occurs, surgeons often attempt to perform a shunt tap. However, the degree of obstruction in a proximal catheter that ultimately leads to shunt malfunction is unknown. MethodsWe developed a benchtop model to simulate proximal catheter occlusion with two...
08:41
Growing skull fractures of the orbital roof: a multicentric experience with 28 patients: AbstractBackgroundGrowing skull fracture (GSF) is a rare condition that may complicate pediatric head trauma. Patients may present with delayed-onset neurological manifestations. AimThis study aims to highlight the different presentations, methods of evaluation, treatment modalities, and outcomes in patients with orbital roof GSF. MethodsThis retrospective multicentric...
08:40
Effects of estrogen and progesterone on the neurogenic inflammatory neuropeptides: implications for gender differences in migraine: AbstractNeurogenic inflammation including calcitonin gene-related peptide (CGRP) and substance-P (SP) release plays a pivotal role in migraine pathogenesis. Prevalence of migraine is ~ 3 folds higher in women than in men, but its underlying mechanisms remained unclear. We investigated the effects of female sex hormones estrogen and progesterone on CGRP and SP in in-vivo...
08:38
Neck rotation modulates motor-evoked potential duration of proximal muscle cortical representations in healthy adults: AbstractTranscranial magnetic stimulation (TMS) produces motor-evoked potentials (MEP) used to infer changes in corticomotor excitability. In humans, neck rotation can probe reticulospinal input on corticomotor output. This study investigated the effect of neck rotation on MEP duration in a proximal and distal upper limb muscle and compared responses between rest and preactivation....
08:38
Is it better to sit down, stand up or walk when performing memory and arithmetic activities?: AbstractIt is now accepted that performing a cognitive task impacts postural control (Polskaia and Lajoie 2016; Vuillerme et al. Neurosci Lett 291: 77–80, 2000). However, the reverse impact of posture on cognitive performance is less documented. The present study investigated performance in two cognitive activities (memory and arithmetic) performed in three different postural conditions (sitting, standing,...
08:37
Pupil diameter as a biomarker of effort in goal-directed gait: AbstractSubjects' eye movement behavior related to cognitive effort during gait was measured as subjects walked to perform low and high cognitive load tasks. We found that all pupil diameter measures, fixation durations, and the proportion of blink duration changed significantly during gait as a function of task load. In contrast, the number of fixations, saccade durations and travel time did not change significantly as a function of...
08:37
Collagen hydrogels loaded with fibroblast growth factor-2 as a bridge to repair brain vessels in organotypic brain slices: AbstractVessel damage is a general pathological process in many neurodegenerative disorders, as well as spinal cord injury, stroke, or trauma. Biomaterials can present novel tools to repair and regenerate damaged vessels. The aim of the present study is to test collagen hydrogels loaded with different angiogenic factors to study vessel repair in organotypic brain slice cultures....
08:36
Early Alteration in Apparent Diffusion Coefficient and Tumor Volume in Cervical Cancer Treated with Chemoradiotherapy or Radiotherapy: Incremental Prognostic Value over Pretreatment Assessments: Concurrent chemoradiotherapy (CCRT) is the established recommended treatment for patients with locally advanced uterine cervical cancer [1–4]. However, approximately 30% of cervical cancer patients receiving CCRT will develop local recurrence or distant metastasis [5]. Therefore, early identification of patients...
08:36
Development and Validation of a Deep Learning Algorithm for Auto-delineation of Clinical Target Volume and Organs at Risk in Cervical Cancer Radiotherapy: Cervical cancer is the second most common cancer in women aged 15 to 44 years worldwide [1,2]. Intensity-modulated radiation therapy (IMRT) has become the preferred radiotherapy method for locally advanced cervical cancer treatment [3]. Accurate delineation of the clinical target volume (CTV) and organ-at-risk (OAR) is one of the essential steps...
08:35
Accuracy of dwell-position detection with a combined electromagnetic tracking brachytherapy system for treatment verification in pelvic brachytherapy: High dose-rate (HDR) brachytherapy (BT) is commonly used to treat prostate and cervical cancer by irradiating the target volume using dedicated applicators and/or catheters. BT offers sharp dose gradients which may lead to decreased dose to organs at risk compared to external beam radiotherapy.[1,2] Image-guided implant reconstruction has become standard...
08:35
TMT-Based Proteomic Analysis of Plasma from Children with Rolandic Epilepsy: Rolandic epilepsy is one of the most common epileptic syndromes in childhood. We used TMT-based proteomics and bioinformatics analysis to identify the differentially expressed proteins in plasma of children with Rolandic epilepsy. Our aim was to provide a molecular basis for exploring possible mechanisms underlying the pathogenesis of epilepsy. Subjects were divided into two groups (five in each): patients with Rolandic...
08:33
Targeted Therapies in the Management of Well-Differentiated Digestive and Lung Neuroendocrine Neoplasms: Opinion statementOngoing advances in our understanding of neuroendocrine tumor (NET) biology, genetics, and immunology, will continue to expand the availability of targeted therapies, thus improving the outcomes of patients. Well-differentiated neuroendocrine tumors (NETs) are grouped into pancreatic and non-pancreatic NETs (includes GI and thoracic NETs) for treatment considerations (Fig. 1)....
08:33
Bilateral Traumatic Facial Paralysis with Hearing Impairment and Abducens Palsy: The temporal bone is often affected in basilar skull fractures. Fractures involving the petrous portion are particularly significant, as they may be associated with neurovascular sequelae. Bilateral facial paralysis secondary to bilateral temporal bone fracture is a rare clinical entity, even more so when associated with other cranial nerve damage such as abducens nerve paralysis and hearing impairment. Only 4 similar...
08:32
Antimicrobial activities of plasma-functionalized liquids against foodborne pathogens on grass carp ( Ctenopharyngodon Idella ): AbstractPlasma-functionalized liquids (PFL) emerge as an effective sanitizer with great potential to be against a variety of microorganisms but their applications on seafood products are limited. In the current study, the physicochemical properties of plasma-functionalized water (PFW) and plasma-functionalized buffer (PFB), and their antimicrobial activities on grass carp,...
08:31
In-depth clinical and biological exploration of DNA Damage Immune Response (DDIR) as a biomarker for oxaliplatin use in colorectal cancer: Purpose: The DNA Damage Immune Response (DDIR) assay was developed in breast cancer (BC) based on biology associated with deficiencies in homologous recombination and Fanconi Anemia (HR/FA) pathways. A positive DDIR call identifies patients likely to respond to platinum-based chemotherapies in breast and oesophageal cancers. In colorectal cancer (CRC) there is...
08:30
CD19-Specific CAR-T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor is Effective in Patients with PD-L1 Positive B-Cell Lymphoma: Purpose: CD19-specific chimeric antigen receptor (CAR)-T cell therapy is effective against refractory or relapsed (R/R) B-cell lymphoma, but the efficacy is hindered by the existence of PD-1/PD-L1 pathway. Experimental Design: Here we generated a novel anti-CD19 CAR expressing PD-1/CD28 chimeric switch-receptor (CD19-PD-1/CD28-CAR). We then conducted a phase 1b...
08:30
Preclinical comparison of the blood brain barrier (BBB) permeability of osimertinib with other EGFR TKIs: Purpose Osimertinib is a potent and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) of both sensitizing and T790M resistance mutations. To treat metastatic brain disease, blood brain barrier (BBB) permeability is considered desirable for increasing clinical efficacy. Experimental Design We examined the level of brain penetration for 16 irreversible and reversible...
08:29
Effect of germline mutations in homologous recombination repair genes on overall survival of patients with pancreatic adenocarcinoma: Purpose: To compare the clinical characteristics and overall survival (OS) of germline mutation carriers in homologous recombination repair (HRR) genes and non-carriers with pancreatic ductal adenocarcinoma (PDAC). Methods: Germline DNA from 3,078 patients with PDAC enrolled in a prospective registry at Mayo Clinic between 2000 and 2017 was analyzed for mutations in...
08:28
Spatiotemporal Heterogeneity in Multiparametric Physiologic MRI Are Associated with Patient Outcomes in IDH-wildtype Glioblastoma: Purpose: Heterogeneity in glioblastomas is associated with poorer outcomes, and physiologic heterogeneity can be quantified with non-invasive imaging. We developed spatial habitats based on multiparametric physiologic magnetic resonance imaging (MRI) and evaluated associations between temporal changes in these habitats and progression-free survival (PFS) after concurrent...
08:28
Improved survival associated with local tumor response following multi-site radiotherapy and pembrolizumab: secondary analysis of a phase I trial: Purpose: Multi-site stereotactic body radiotherapy followed by pembrolizumab (SBRT+P) has demonstrated safety in advanced solid tumors (AST). However, no studies have examined the relationships between irradiated tumor response, SBRT-induced tumor gene expression, and overall survival (OS). Experimental Design: Patients with AST received SBRT (30-50...
08:27
Development and validation of a next-generation sequencing-based multigene assay to predict the prognosis of estrogen receptor-positive, HER2-negative breast cancer: Purpose: Multigene assays provide useful prognostic information regarding hormone receptor (HR)-positive breast cancer. Next-generation sequencing (NGS)-based platforms have numerous advantages including reproducibility and adaptability in local laboratories. This study aimed to develop and validate an NGS-based multigene assay to predict...
08:26
Novel Methylated DNA Markers in the Surveillance of Colorectal Cancer Recurrence: Purpose: We aimed to assess the concordance of colorectal cancer (CRC)-associated methylated DNA markers (MDMs) in primary and metastatic CRC for feasibility in detection of distantly recurrent/metastatic CRC in plasma. Experimental Design: A panel of previously discovered CRC-associated MDMs was selected. MDMs from primary and paired metastatic CRC tissue were assayed with quantitative methylation-specific PCR. Plasma...
08:20
General first-order target registration error model considering a coordinate reference frame in an image-guided surgical system: AbstractPoint-based rigid registration (PBRR) techniques are widely used in many aspects of image-guided surgery (IGS). Accurately estimating target registration error (TRE) statistics is of essential value for medical applications such as optically surgical tool-tip tracking and image registration. For example, knowing the TRE distribution statistics of surgical tool tip...
08:19
The Virtual Circular Genome Model for Primordial RNA Replication [Hypothesis]: We propose a model for the replication of primordial protocell genomes that builds upon recent advances in the nonenzymatic copying of RNA. We suggest that the original genomes consisted of collections of oligonucleotides beginning and ending at all possible positions on both strands of one or more virtual circular sequences. Replication is driven by feeding with activated monomers and by the activation of monomers and...
08:19
SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction: Undifferentiated carcinoma of the esophagus and gastroesophageal junction is a recently recognized entity in the fifth edition of the World Health Organization Classification of Digestive Tumors and is diagnostically challenging, particularly on small biopsies. SMARCA4 and SMARCA2 are chromatin remodeling genes with key roles in oncogenesis. We retrieved 14 cases of SMARCA4/SMARCA2-deficient undifferentiated carcinoma...
08:18
Molecular Profiling of Clear Cell Myoepithelial Carcinoma of Salivary Glands With EWSR1 Rearrangement Identifies Frequent PLAG1 Gene Fusions But No EWSR1 Fusion Transcripts: Myoepithelial carcinoma of salivary glands is an underrecognized and challenging entity with a broad morphologic spectrum, including an EWSR1-rearranged clear cell variant. Myoepithelial carcinoma is generally aggressive with largely unknown genetic features. A retrospective review of Salivary Gland Tumor Registry in Pilsen searching...
08:18
Should we stick with surgical glues? The incidence of dermatitis after 2-octyl cyanoacrylate exposure in 102 consecutive breast cases.: No abstract available
08:17
The "3P" maneuver: a simple technique to improve vascular safety in nonsurgical rhinoplasty: No abstract available SURGICAL TECHNIQUEAnesthetic cream (EMLA; AstraZeneca, Basiglio, MI, Italy) is applied 20 minutes before the procedure. Meticulous disinfection is performed with chlorhexidine gluconate 2%.DorsumWith the patient lying down, the lowest point of the dorsum is visualized and injected. To reduce the risk for intravascular injection and HA displacement, the author performs the "pinch,...
08:15
A Ray of Optimism in Treatment of Ring Avulsion Injury: No abstract available Related ArticlesThe Impact of Microsurgery on the Treatment of Ring Avulsion InjuriesPLASTIC AND RECONSTRUCTIVE SURGERYDecember 2019Comment on "The Impact of Microsurgery on the Treatment of Ring Avulsion Injuries"PLASTIC AND RECONSTRUCTIVE SURGERYOctober 2020Discussion: Appropriateness of the Use of Magnetic Resonance Imaging in the Diagnosis and Treatment of Wrist Soft Tissue InjuryPLASTIC AND RECONSTRUCTIVE SURGERYFebruary...
08:09
Evaluation of sleep quality and restless legs syndrome in adult patients with sickle cell anemia: AbstractPurposeTo determine the prevalence of poor sleep quality and RLS in adult patients with sickle cell anemia (SCA). The second aim was to identify the risk factors for RLS and impairment of sleep quality in SCA patients. Materials and methodsPatients at least 18 years old, with hemoglobin electrophoresis confirmation of sickle cell disease, were included. Restless legs syndrome...
08:08
A rare case of atypical spinal neurocytoma with EGFR mutation in a 12-year-old boy: AbstractSpinal neurocytoma (SN), although frequently reportedly as tumors of the central nervous system (CNS), are a distinct class of tumors, which can achieve a better prognosis following subtotal or gross total tumor resection. Nonetheless, even with the premise of successful treatment after tumor resection, poor prognosis after treatment due to the SN high proliferation index (typically known as atypical SN) have...
08:07
Interferon Beta-1b and Lopinavir–Ritonavir for Middle East Respiratory Syndrome: Over the past two decades, emerging coronaviruses (CoVs) have caused three major outbreaks — severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (Covid-19). Since MERS was reported in Saudi Arabia in 2012, at least 2494 cases and 858…
08:06
Allergy to Peanuts imPacting Emotions And Life (APPEAL): the impact of peanut allergy on children, adolescents, adults and caregivers in France: Peanut allergy (PA) has increased in developed countries and can have a dramatic effect on quality of life but data surrounding this is limited in France. Allergy to Peanuts imPacting Emotions And Life study (...
08:05
Protective effect of 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione, isolated from Averrhoa carambola L., against Aβ1–42-induced apoptosis in SH-SY5Y cells by reversing Bcl-2/Bax ratio: AbstractBackground and purposeAβ1–42-induced neurotoxicity has been considered as a possible mechanism to aggravate the onset and progression of Alzheimer's disease (AD). In this study, we aim to determine the protective effect of DMDD on the apoptosis of SH-SY5Y cells induced by Aβ1–42 and elucidate potential...
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International Journal of Environmental Research...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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