Persistent primitive olfactory artery associated with early bifurcated accessory anterior cerebral artery

xlomafota13 shared this article with you from Inoreader Persistent primitive olfactory artery associated with early bifurcated accessory anterior cerebral artery Via radiol anat Surg Radiol Anat. 2021 Apr 6. doi: 10.1007/s00276-021-02744-3. Online ahead of print. ABSTRACT Five types of persistent primitive olfactory artery (PPOA), a rare variation of the proximal anterior cerebral artery (ACA), have been reported. Type 1 is most common, generally following an extreme anteroinferior course and taking a hairpin turn before continuing to the distal A2 segment of the ACA. Triple ACAs are a common variation of the A2 segment of the ACA, and a centrally l ocated artery is called an "accessory ACA" or "median artery of the corpus callosum". This artery usually does not bifurcate or else bifurcates distally and continues to the pericallosal artery. We herein report a 74-year-old woman with type 1 PPOA and early bifurcated accessory ACA, an extremely rare combination of ACA variations, that was diagnosed using magnetic resonance angiography. PMID:33825050 | DOI:10.1007/s00276-021-02744-3 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Esophageal Tuberculosis: A Systematic Review

xlomafota13 shared this article with you from Inoreader Esophageal Tuberculosis: A Systematic Review Via Otolaryngology Indian Abstract Involvement of esophagus with tuberculous infection is a rare form of extrapulmonary tuberculosis. Secondary esophageal tuberculosis is much more common than primary TB. The most common source of secondary esophageal involvement is tuberculous mediastinal lymphadenitis. Esophageal tuberculosis mimics carcinoma esophagus. Clinical features are same and it is difficult on imaging studies also to differentiate the two pathologies. Misdiagnosis is common. The disease is medically curable; therefore, it is essential to make all efforts to diagnose the pathology with non-surgical diagnostic modalities in suspected cases so as to save patients from the trauma of major surgical resection. Surgical intervention is indicated for failed medical therapy and complications. A total of 133 cases of esophageal TB have been reported till date. The authors encountered 4 cases of esophageal TB between April 2011 and March 2019. The aim of this article is to present our data and to provide comprehensive review of the available literature on this pathology in order to gain a better understanding of diagnostic methods and provide guidelines for the diagnosis and management of esophageal TB. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Endaural Over-Underlay Cartilage Tympanoplasty for Repair of Dry Subtotal Perforations

xlomafota13 shared this article with you from Inoreader Endaural Over-Underlay Cartilage Tympanoplasty for Repair of Dry Subtotal Perforations Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Apr 7:34894211007218. doi: 10.1177/00034894211007218. Online ahead of print. ABSTRACT OBJECTIVES: We explored the auditory and anatomical success of grafting when the cartilage perichondrium (CP) was prepared using two different methods. METHODS: Patients with subtotal or total perforation underwent tympanoplasty with a CP graft. A V-shaped groove for the handle of the malleus was prepared for CP grafts in patients in group 1. Pati ents in group 2 did not have a groove on the graft. The anatomical success of the graft was evaluated as success, partial success, or failure. Results of auditory evaluations were compared between the two groups. RESULTS: A total of 195 patients were included in the study. The total CP graft integration rate was 96% for both groups. Significant changes were detected in all hearing criteria evaluated 12 months after surgery compared to the preoperative period (P < .05). There were no significant differences between the groups in terms of the relationship between graft technique and postoperative hearing results. However, rates of partial success were significantly higher for group 1 than group 2 (P = .033). CONCLUSION: Cartilage slice support offers an extremely reliable method for reconstruction of tympanic membrane in cases of high-risk perforation. Partial failures are rare, but when they occur, they most often involved anterior graft medialization. Wh en a piece of cartilage is removed at the malleus interface there may be a higher rate of partial failure. PMID:33825491 | DOI:10.1177/00034894211007218 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Persistent mdx diaphragm alterations are accompanied by increased expression and activity of calcium and muscle-specific proteins

xlomafota13 shared this article with you from Inoreader Persistent mdx diaphragm alterations are accompanied by increased expression and activity of calcium and muscle-specific proteins Via Cellular and Molecular Biology Histol Histopathol. 2021 Apr 7:18334. doi: 10.14670/HH-18-334. Online ahead of print. ABSTRACT The mdx mouse model of Duchenne Muscular Dystrophy (DMD) presents sarcolemma instability and develops a mild multi-stage dystrophinopathy characterized by intense myonecrosis with inflammatory infiltrate at 4-weeks; muscular regeneration at 12-weeks and persistent fibrosis onwards. Mdx diaphragm muscle has a more severe phenotype with structural and functional deterioration that closely resembles the diaphragm impairment responsible for DMD human patients' morbidity. Herein, we compared calcium deposits, activity of calcium-related proteases, and expression of muscle-specific proteins in mdx diaphragm at 4-weeks and 12-weeks. We found increased calcium deposits mainly at 12-weeks, concomitant with high activity of calpains and matrix metaloprotease-9, but decreased expression of Myhc4 (Myhc IIb) and Atpa2a1 (SERCA1), and high expression of th e myogenic regulatory factors Myod1 and Myog. Our results suggest that increased calcium deposits and persistent activity of calcium dependent proteases throughout the disease are involved in the degeneration and regeneration processes in the mdx diaphragm. PMID:33825181 | DOI:10.14670/HH-18-334 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Robot‐Assisted Versus Open Radical Cystectomy: A Cohort Study on Perioperative Outcomes Accounting for Stage Selection Bias and Surgical Experience

xlomafota13 shared this article with you from Inoreader Robot‐Assisted Versus Open Radical Cystectomy: A Cohort Study on Perioperative Outcomes Accounting for Stage Selection Bias and Surgical Experience Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background Most comparisons of robot‐assisted (RARC) versus open radical cystectomy (ORC) for urothelial carcinoma do not factor the inherent stage selection bias or surgical experience. Methods We compared the perioperative outcomes of 229 RARC and 335 ORC at a single tertiary referral center with propensity score matching and multiple regression models, when controlling for tumor and patient characteristics, surgeon's experience and type of urinary diversion. Results RARC had less major complications (19.8% vs. 34.1%) and ICU admissions (6.6% vs. 19.8%), with lower blood loss (400 vs. 500ml) and transfusion rates. The operating time was longer (336 vs. 286min), but decreased with surgeon's experience. RARC had less PSMs (3% vs. 8.4%) and a higher lymph node count (14 vs. 11). Conclusions In this large single center series comparing RARC with ORC controlling for stage selection bias and surgical experience, RARC proved significantly better outcomes, especially with intracorporeal urinary diversion. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Rare Case of Sphenoid Sinus Mucocele Presenting with Lateral Rectus Palsy

xlomafota13 shared this article with you from Inoreader A Rare Case of Sphenoid Sinus Mucocele Presenting with Lateral Rectus Palsy Via Otolaryngology Indian Abstract The sphenoid sinus mucoceles are rare and have an incidence of 1%, when sufficiently large they can compress optic canal, superior orbital fissure and vital structures causing optic neuropathy, ptosis, ophthalmoplegia and diplopia. We herein report a 73 year old male who presented with headache and left lateral rectus palsy secondary to sphenoid sinus mucocele which was confirmed on MRI and successfully treated with endoscopic marsupialization. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prevalence and predictors of obesity-related cancers among racial/ethnic groups with metabolic syndrome

xlomafota13 shared this article with you from Inoreader Prevalence and predictors of obesity-related cancers among racial/ethnic groups with metabolic syndrome Via Head and neck cancers by Shanada Monestime, Bettina Beech, Dulcie Kermah, Keith Norris Background Obesity-related cancer (ORC) is associated with higher amounts of body fat, which could increase the risk of developing cardiovascular disease (CVD). A significant factor associated with CVD is metabolic syndrome (MetS), and MetS prevalence differs by race/ethnicity. The purpose of this study was to compare the prevalence and predictors of ORCs by race/ethnicity among adults (>18) with MetS. Methods This was a retrospective, cross-sectional study using data from the 1999–2014 National Health and Nutrition Examination Survey (NHANES). A chi-square test was performed to determine differences in ORC prevalence between non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic participants with MetS. A multivariate logistic regression was used to evaluate predictors (race, sex, income, insurance, education, marital status, and smoking status) of ORC among adults with MetS. Results Of the 1,554 adults, the prevalence of ORC was 30.6% among NHWs, 51.3 % in NHBs, and 54.1% in Hispanics (p = Conclusions Among NHANES participants with MetS, the prevalence of ORCs was significantly higher in NHBs and Hispanics, females, and older adults with MetS. Future studies, by race/ethnicity, are warranted on mortality risk of persons with MetS and ORC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Long Noncoding RNA NEAT1: A Potential Biomarker in the Progression of Laryngeal Squamous Cell Carcinoma

xlomafota13 shared this article with you from Inoreader Long Noncoding RNA NEAT1: A Potential Biomarker in the Progression of Laryngeal Squamous Cell Carcinoma Via O.R.L. Journal for oto-rhino-laryngology and its borderlands Introduction: Laryngeal squamous cell carcinoma (LSCC) is diverse in its natural history and responsiveness to treatments. There is an urgent need to generate candidate biomarkers for the stratification and individualization of treatment to avoid overtreatment or inadequate treatment. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been identified as an oncogenic gene in multiple human tumors entitles, and dysregulation of NEAT1 was tightly linked to carc inogenesis and cancer progression. Methods: One hundred two paraffin samples of LSCC patients were collected. Furthermore, in situ hybridization (ISH), Kaplan-Meier, and MTT were used to analyze the relationship between NEAT1 and the progress of LSCC. Results: In this study, ISH revealed that NEAT1 was strongly expressed in the nucleus. The increased expression of NEAT1 was correlated with T grade, neck nodal metastasis, clinical stage, drinking history, or smoking history of LSCC. The Kaplan-Meier analysis indicated that patients with higher NEAT1 expression had a worse overall survival in LSCC patients. In addition, NEAT1 knockdown significantly inhibited the growth of LSCC cells. Conclusion: Together, these results suggested that NEAT1 involved in the progress of LSCC and might act as a tumor oncogenic gene. This study provides a potential new marker and target for gene therapy in the treatment of LSCC. ORL View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Povidone Iodine (PVP-I) Oro-Nasal Spray: An Effective Shield for COVID-19 Protection for Health Care Worker (HCW), for all

xlomafota13 shared this article with you from Inoreader Povidone Iodine (PVP-I) Oro-Nasal Spray: An Effective Shield for COVID-19 Protection for Health Care Worker (HCW), for all Via Otolaryngology Indian Abstract SARS- CoV-2 or novel coronavirus enters in human body through nose and mouth, stays there for a while. Then binds with ACE2 receptor, enters inside cell, multiply there and manifests. Again, Polyvinyl Pyrrolidone or Povidone Iodine (PVP-I) is a strong microbicidal agent having 99.99% virucidal efficacy in its only 0.23% concentration, irrespective of all known viruses, even in SARS- CoV-2 (in vitro). An oro-nasal spray is designed to apply the PVP-I in nose and oral cavity to gain a protective layer or coating over nasal and oral mucosa, so that SARS-CoV-2 can't bind with the ACE-2 receptor and prevent their entry inside. So, it will be effective for prevention of COVID-19. Moreover, as PVP-I has the ability for destruction of SARS-CoV-2, transmission of SARS- CoV-2 from patient will be reduced also. Thus PVP-I oro-nasal spray can act as an effective shield for COVID-19 protection for healthcare workers, for all. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Relative Topography of Laryngeal Nerves for Surgical Cruciality: An Observational Cadaveric Study

xlomafota13 shared this article with you from Inoreader Relative Topography of Laryngeal Nerves for Surgical Cruciality: An Observational Cadaveric Study Via Otolaryngology Indian Abstract To observe and evaluate the intricrate relationship of recurrent laryngeal nerve (RLN) and external branch of superior laryngeal nerve (EBSLN) to various anatomical structures in the neck like the inferior thyroid artery (ITA), Berry's ligament (LB), Zuckerkandl's tubercle (ZT) and with the superior thyroid artery (STA) for the knowledge of surgical cruciality during surgeries for thyroid gland diseases. This cadaveric observational study was conducted in the department of Otorhinolaryngology and Head and Neck Surgery with logistic support from Department of Anatomy. Total of 40 fresh frozen latex injected cadavers neck dissection was performed to study anatomical variations of thyroid gland and its related vessels and nerves. All measurements were recorded using digital caliper sensitive to 0.01 mm and photographs were documented. Topography of RLN was studied in relation to ITA, LB and ZT. The RLN was predominantly a posterior relation of the ITA in 86.2 5%, was deep to LB in 46.25% and was related posterior to ZT in 80% of cadaver dissected. The EBSLN has a variable relation with STA which was observed to lie at a distance of < 1 cm from STA in 66.25%. The difference between left and right side was not found to be statistically significant in all parameters (p > 0.05). The awareness and appreciation of the intricate topographical relations and its variations reinforce the surgeons to be careful when performing surgical procedures in the central compartment of the neck which avoid complications. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Combined Karapandzic and radial forearm free flap with dual palmaris longus tendons for complex lip reconstruction

xlomafota13 shared this article with you from Inoreader Combined Karapandzic and radial forearm free flap with dual palmaris longus tendons for complex lip reconstruction Via Otolaryngology-Head and Neck Surgery Publication date: Available online 7 April 2021 Source: Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): Taylor Freeman, Ryan Ivancic, Amit Agrawal, Enver Ozer, Stephen Y. Kang, Matthew O. Old, Nolan B. Seim View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Short‐Term Exposure to Air Pollution and Epiglottitis: A Nested Case–Control Study

xlomafota13 shared this article with you from Inoreader Short‐Term Exposure to Air Pollution and Epiglottitis: A Nested Case–Control Study Via The Laryngoscope Objectives/Hypothesis This study investigated the impacts of air pollution and meteorological factors on the occurrence of epiglottitis. Study Design A nested case‐control study. Methods Participants ≥40 years old in the Korean National Health Insurance Service‐Health Screening Cohort were analyzed. A total of 2,615 epiglottitis patients and 10,460 matched control participants were analyzed. The odds ratios (ORs) for epiglottitis associated with meteorological and air pollution factors, including sulfur dioxide (SO2, ppb), nitrogen dioxide (NO2, ppb), ozone (O3, ppb), and carbon monoxide (CO, ppm), after 3, 7, 15, and 30 days of exposure were analyzed using conditional logistic regression adjusted for total cholesterol, blood pressure, fasting blood glucose, obesity, smoking, alcohol consumption, prior upper respiratory infection, tonsillectomy, immunocompromise, autoimmune disease, and the Charlson comorbidity index. Results The daily temperature range and NO2 exposure after 3 days were associated with increased rates of epiglottitis (OR = 1.03, 95% confidence interval [CI] = 1.02–1.05 for temperature range and OR = 1.78, 95% CI = 1.14–2.77 for NO2, respectively). These results were generally consistent at 7, 15, and 30 days. Conclusions The temperature range and NO2 exposure for 3, 7, 15, and 30 days were positively related to the occurrence of adult epiglottitis. Level of Evidence 3 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.