Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wyyBwc
Κυριακή 2 Σεπτεμβρίου 2018
A novel case of an aggressive superficial spindle cell sarcoma in an adult resembling fibrosarcomatous dermatofibrosarcoma protuberans and harboring an EML4‐NTRK3 fusion
Changes in plasma interleukin-8 and tumor necrosis factor-α levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma
Abstract
Purpose
This study aimed to identify a biomarker for predicting the response to sorafenib in patients with hepatocellular carcinoma (HCC).
Methods
Of 100 patients with unresectable HCC who received sorafenib treatment in our institute (Cohort A), 48 had stored plasma samples collected within 28 days before the start of treatment (Cohort B). Concentrations of 18 plasma cytokines were measured in plasma samples using a sandwich immunoassay with multiplexed fluorescent bead-based technology. Among 27 patients with follow-up plasma samples taken at 5–10 days of treatment (Cohort C), changes in the 18 cytokines were also evaluated.
Results
In Cohort A, progressive disease (PD) according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST) was associated with poor overall survival by multivariate analysis (p = 0.024). In Cohort B, no significant differences in baseline concentrations of α-fetoprotein, des-γ-carboxy prothrombin, or the 18 cytokines were found between patients with PD and those with stable disease (SD) or partial response (PR). In Cohort C, the increase in interleukin-8 and tumor necrosis factor-α (TNF-α) was significant in the PD group (p = 0.0063 and p < 0.001, respectively) but not in the SD + PR group (p = 0.67 and p = 0.15, respectively). In addition, the fold changes in interleukin-8 and in TNF-α were correlated (p < 0.001, r = 0.67).
Conclusions
Changes in plasma interleukin-8 and TNF-α levels during the first few days could predict the response to sorafenib therapy in HCC patients.
https://ift.tt/2Ndv146
Mycobacterium abscessus infection following penetrations through wetsuits
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2LScJ3I
Mycobacterium abscessus infection following penetrations through wetsuits
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2LScJ3I
Adjuvant treatment of chronic plaque psoriasis in adults by a herbal combination: Open German trial and review of the literature
Dermatologic Therapy, EarlyView.
https://ift.tt/2LQDiXb
Sudanese Association of Dermatologists Special Meeting, Khartoum, Sudan
Dermatologic Therapy, EarlyView.
https://ift.tt/2wBkWEG
Adjuvant treatment of chronic plaque psoriasis in adults by a herbal combination: Open German trial and review of the literature
Dermatologic Therapy, EarlyView.
https://ift.tt/2LQDiXb
Sudanese Association of Dermatologists Special Meeting, Khartoum, Sudan
Dermatologic Therapy, EarlyView.
https://ift.tt/2wBkWEG
Common allergies in urban adolescents and their relationships with asthma control and healthcare utilization
Urban adolescents suffer a disproportionate burden of asthma morbidity, often in association with allergies. Literature is limited on comparing various types of allergies regarding prevalence and associations ...
https://ift.tt/2PXRUXX
Hemolysis induced cross-matching difficulty with intravenous immunoglobulin: a case report
Intravenous immunoglobulin is one of the most common modalities of treatment for Guillain–Barré syndrome. Although minor complications are easily preventable with pre-medications, rare complications like hemol...
https://ift.tt/2NCXrS6
The use of a skin-stretching device combined with vacuum sealing drainage for closure of a large skin defect: a case report
This case report presents the treatment of a large infected skin defect, which was caused by an accidental explosion, through a skin-stretching device combined with vacuum sealing drainage. To the best of our ...
https://ift.tt/2Nceg9v
Ertapenem for the treatment of Hidradenitis suppurativa: how much do we need it?
Prevention and treatment of tuberculosis infection in candidates for biologic therapy: A multidisciplinary consensus statement adapted to the dermatology patient
P. Rodríguez-Jiménez, I. Mir-Viladrich, P. Chicharro, G. Solano-López, F.J. López-Longo, C. Taxonera, P. Sánchez-Martínez, X. Martínez-Lacasa, M. García-Gasalla, J. Dorca, M. Arias-Guillén, J.M. García-García, E. Dauden
Actas Dermosifiliogr.2018;109:584-601
Abstract - Full text - PDF
https://ift.tt/2oA1tj6
Allergic Contact Dermatitis Due to Paraphenylenediamine: An Update
The First Year of the AEVD Primary Cutaneous Lymphoma Registry
Y. Peñate, O. Servitje, S. Machan, R. Fernández-de-Misa, M.T. Estrach, E. Acebo, J. Mitxelena, M.D. Ramón, A. Flórez, M. Blanes, M. Morillo, S. Medina, J. Bassas, A. Zayas, P. Espinosa, A. Pérez, N. Gónzalez-Romero, J.D. Domínguez, C. Muniesa, J. López Robles, A. Combalia, I. Yanguas, H. Suh, I. Polo-Rodríguez, I. Bielsa, A. Mateu, B. Ferrer, M.A. Descalzo, I. García-Doval, P.L. Ortiz-Romero
Actas Dermosifiliogr.2018;109:610-6
Abstract - Full text - PDF
https://ift.tt/2oxKWMD
Description of Patients Treated with Biologic Drugs as First-Line Systemic Therapy in the BIOBADADERM Registry Between 2008 and 2016
G. Carretero Hernández, C. Ferrándiz, R. Rivera Díaz, E. Daudén Tello, P. de la Cueva-Dobao, F.J. Gómez-García, E. Herrera-Ceballos, I. Belinchón Romero, J.L. López-Estebaranz, M. Alsina Gibert, J.L. Sánchez-Carazo, M. Ferrán Farrés, A. González Quesada, J.M. Carrascosa Carrillo, M. Llamas-Velasco, M.V. Mendiola Fernández, D. Ruiz Genao, C. Muñoz Santos, I. García-Doval, M.A. Descalzo
Actas Dermosifiliogr.2018;109:617-23
Abstract - Full text - PDF
https://ift.tt/2CdDeB2
Practice Models in Teledermatology in Spain: Longitudinal Study, 2009-2014
Management of Moderate to Severe Psoriasis in Routine Clinical Practice in Spanish Hospitals
Idiopathic Facial Aseptic Granuloma: Clinical and Ultrasound Findings in 3 Cases
Pityriasis Lichenoides et Varioliformis Acuta Associated With Human Herpesvirus 7
Ulcerated Penile Lesion
Máculas evanescentes en tronco y extremidades
Tumor Collision Over Sebaceous Nevus: Clues for Dermoscopic Diagnosis
Quality of Life in Nonmelanoma Skin Cancer
Rare Tongue Compromising of Mucocutaneous Leishmaniasis by Leishmania Subgenus Viannia
Cervical Cellulitis of Odontogenic Origin
Agminated Dermal Melanocytosis in the Territory of Ota's Nevus
Enfermedad de Rosai-Dorfman cutánea: una nueva presentación clínica
A Wilms’ Tumor with Spinal Cord Compression: An Extrarenal Origin?
Spinal cord compression in Wilms' tumor (WT) is an extremely rare event that can have a very poor prognosis if not taken care of rapidly. Most cases reported in the literature involve widely metastatic patient with bone or paraspinal metastases or occasionally intradural metastasis. Here, we present the case of a 3-year-old girl of WT confirmed by biopsy, with spinal cord compression due to the direct contiguous spread of a tumor through 2 vertebral foramina. Abdominal ultrasonography and magnetic resonance imaging performed for an abdominal mass revealed a large heterogeneous tumor near the upper pole of the left kidney. A nodular infiltration extended through the T11-L1 and L1-L2 neural foramina, forming an intraspinal mass that compressed the spinal cord. Major paresthesia subsequently occurred, requiring urgent treatment with corticosteroids and chemotherapy. The evolution was rapidly satisfying. After six courses of chemotherapy, a left nephrectomy was performed. Macroscopic examination identified a large tumor attached to the kidney without renal infiltration. Microscopical examination concluded to a nephroblastoma with regressive changes, of intermediate risk. Evolution at 6 months is satisfactory, with no neurological deficit. The histological aspect of the tumor and the clinical outcome suggest that she had an extrarenal WT that spread through the vertebral foramina and was secondarily attached to the kidney.
https://ift.tt/2PA5pfB
Issue Information
The Journal of Dermatology, Volume 45, Issue 9, Page 1147-1147, September 2018.
https://ift.tt/2ozlAxY
Possible contribution of autophagy in pyogenic granuloma
The Journal of Dermatology, Volume 45, Issue 9, Page 1145-1146, September 2018.
https://ift.tt/2Pxrjju
Issue Information
The Journal of Dermatology, Volume 45, Issue 9, Page i, 1029-1030, September 2018.
https://ift.tt/2ozHZLL
Growth of patients with congenital adrenal hyperplasia due to 21-hydroxylase in infancy, glucocorticoid requirement and the role of mineralocorticoid therapy
Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print
https://ift.tt/2NcNU7g
Brain network connectivity associated with anticipatory postural control in children and adults
Publication date: Available online 1 September 2018
Source: Cortex
Author(s): Fabien Cignetti, Marianne Vaugoyeau, Leslie M. Decker, Marie-Hélène Grosbras, Nadine Girard, Yves Chaix, Patrice Péran, Christine Assaiante
Abstract
Internal models provide a coherent framework for understanding motor behavior. Examples for the use of internal models include anticipatory postural adjustments (APAs), where the individual anticipates and cancels out the destabilizing effect of movement on body posture. Yet little is known about the functional changes in the brain supporting the development of APAs. Here, we addressed this issue by relating individual differences in APAs as assessed during bimanual load lifting to interindividual variation in brain network interactions at rest. We showed that the strength of the connectivity between three main canonical brain networks, namely the cingulo-opercular, the fronto-parietal and the somatosensory-motor networks, is an index of the ability to implement APAs from late childhood (9- to 11-year-old children). We also found an effect of age on the relationship between APAs and coupling strength between these networks, consistent with the notion that APAs are near but not yet fully mature in children. We discuss the implications of these findings for our understanding of learning disorders with impairment in predictive motor control.
https://ift.tt/2NF9MoX
Trauma exposure acutely alters neural function during Pavlovian fear conditioning
Publication date: Available online 1 September 2018
Source: Cortex
Author(s): Nathaniel G. Harnett, Edward W. Ference, Kimberly H. Wood, Muriah D. Wheelock, Amy J. Knight, David C. Knight
Abstract
Posttraumatic stress disorder (PTSD) is associated with dysfunction of the neural circuitry that supports fear learning and memory processes. However, much of what is known about neural dysfunction in PTSD is based on research in chronic PTSD populations. Less is known about neural function that supports fear learning acutely following trauma exposure. Determining the acute effects of trauma exposure on brain function would provide new insight into the neural processes that mediate the cognitive-affective dysfunction associated with PTSD. Therefore, the present study investigated neural activity that supports fear learning and memory processes in recently Trauma-Exposed (TE) and Non-Trauma-Exposed (NTE) participants. Participants completed a Pavlovian fear conditioning procedure during functional magnetic resonance imaging (fMRI). During fMRI, participants' threat expectancy was continuously monitored. NTE participants showed greater threat expectancy during warning than safety cues, while no difference was observed in the TE group. This finding suggests TE participants overgeneralized the fear association to the safety cue. Further, only the TE group showed a negative relationship between fMRI signal responses within dorsomedial prefrontal cortex (PFC) and threat expectancy during safety cues. These results suggest the dorsomedial PFC mediates overgeneralization of learned fear as an acute result of trauma exposure. Finally, neural activity within the PFC and inferior parietal lobule showed a negative relationship with PTSD symptom severity assessed three months posttrauma. Thus, neural activity measured acutely following trauma exposure predicted future PTSD symptom severity. The present findings elucidate the acute effects of trauma exposure on cognitive-affective function and provide new insight into the neural mechanisms of PTSD.
https://ift.tt/2oyxk3G
Polarity-Dependent Modulation of Multi-Spectral Neuronal Activity by Transcranial Direct Current Stimulation
Publication date: Available online 1 September 2018
Source: Cortex
Author(s): Alex I. Wiesman, Mackenzie S. Mills, Timothy J. McDermott, Rachel K. Spooner, Nathan M. Coolidge, Tony W. Wilson
Abstract
The ability to preferentially deploy neural resources to the visual space is an important component of normative cognitive function, however, the population-level cortical dynamics that sub-serve this ability are not fully understood. Specifically, rhythmic activity in the occipital cortices (e.g., theta, alpha, and gamma oscillations) has been strongly implicated in this cognitive process, but these neural responses are difficult to non-invasively manipulate in a systematic manner. In this study, transcranial direct-current stimulation (tDCS) was used to modulate brain activity, while high-density magnetoencephalography (MEG) was employed to quantify changes in rhythm-specific neural activity in the occipital cortices of 57 adults performing a visuospatial processing paradigm. All MEG data was analyzed using advanced source reconstruction and oscillatory analysis methods. Our results indicated that basal levels of occipital alpha activity were increased by an occipital-anodal/supraorbital-cathodal tDCS montage, while basal gamma levels in the same cortices were decreased by tDCS using the same montage with its polarity reversed (occipital-cathodal/supraorbital-anodal). In other words, stimulation with the occipital-anodal montage increased local spontaneous alpha (10-16 Hz) activity, while stimulation with the occipital-cathodal montage selectively decreased local gamma (64-90 Hz) activity. Neither polarity affected stimulus-induced oscillations in the alpha or gamma range. Additionally, these modulations strongly predicted the subsequent formation of fronto-visual functional connectivity within distinct oscillatory rhythms, as well as behavior on the visuospatial discrimination task. These findings provide insight into the multifaceted effects of tDCS on cortical activity, as well as the dynamic oscillatory coding of salient information in the human brain.
https://ift.tt/2NJrxnf
Morphological processing in the brain: the good (inflection), the bad (derivation) and the ugly (compounding)
Publication date: Available online 1 September 2018
Source: Cortex
Author(s): A. Leminen, E. Smolka, J.A. Duñabeitia, C. Pliatsikas
Abstract
There is considerable behavioral evidence that morphologically complex words such as 'tax-able' and 'kiss-es' are processed and represented combinatorially. In other words, they are decomposed into their constituents 'tax' and '-able' during comprehension (reading or listening), and producing them might also involve on-the-spot combination of these constituents (especially for inflections). However, despite increasing amount of neurocognitive research, the neural mechanisms underlying these processes are still not fully understood. The purpose of this critical review is to offer a comprehensive overview on the state-of-the-art of the research on the neural mechanisms of morphological processing. In order to take into account all types of complex words, we include findings on inflected, derived, and compound words presented both visually and aurally. More specifically, we cover a wide range of electro- and magnetoencephalography (EEG and MEG, respectively) as well as structural/functional magnetic resonance imaging (s/fMRI) studies that focus on morphological processing. We present the findings with respect to the temporal course and localization of morphologically complex word processing. We summarize the observed findings, their interpretations with respect to current psycholinguistic models, and discuss methodological approaches as well as their possible limitations.
https://ift.tt/2N7pDzz
Kératodermie acrale symétrique : responsabilité de mutations d’un facteur de transcription
Publication date: Available online 1 September 2018
Source: Annales de Dermatologie et de Vénéréologie
Author(s): O. Dereure
https://ift.tt/2wvICKH
Altered expression of microRNA-23a in psoriatic arthritis modulates synovial fibroblast pro-inflammatory mechanisms via phosphodiesterase 4B
Publication date: Available online 1 September 2018
Source: Journal of Autoimmunity
Author(s): Sarah M. Wade, Michelle Trenkmann, Trudy McGarry, Mary Canavan, Viviana Marzaioli, Siobhan C. Wade, Douglas J. Veale, Ursula Fearon
Abstract
Objectives
To investigate the functional role of miR-23a in synovial fibroblasts (SFC) activation in psoriatic arthritis (PsA).
Methods
Differential expression of the miR-23a-27a-24-2 cluster was identified by real-time quantitative PCR in PsA synovial tissue and peripheral blood mononuclear cells (PBMC) compared to osteoarthritis (OA) and correlated with disease activity. For regulation experiments, PsA synovial fibroblasts (SFC) were cultured with Toll-like receptor (TLR) ligands and pro-inflammatory cytokines. PsA SFC were transfected with a miR-23a inhibitor to assess the functional effect on migration, invasion and expression of pro-inflammatory meditators. The direct interaction between miR-23a and predicted target mRNA, phosphodiesterase 4B (PDE4B), was examined by luciferase reporter gene assay, with the expression and regulation confirmed by RT-PCR and western blot. A PDE4 inhibitor was used to analyse the function of PDE4B signalling in both miR-23a and Poly(I:C)-induced PsA SFC activation.
Results
Synovial tissue expression of miR-23a was lower in PsA compared to OA and correlated inversely with disease activity and synovitis. TLR activation via Poly(I:C) and LPS, but not Pam3CSK4, significantly decreased miR-23a expression, with no significant effect observed in reponse to stimulation with pro-inflammatory cytokines. Decreased miR-23a expression enhanced PsA SFC migration, invasion and secretion of IL-6, IL-8, MCP-1, RANTES and VEGF. We identified PDE4B as a direct target of miR-23a and demonstrated enhanced mRNA and protein expression of PDE4B in anti-miR-23a transfected PsA SFC. Poly(I:C) and/or miR-23a-induced migration and enhanced cytokine expression was suppressed by the blockade of PDE4 signalling.
Conclusions
In PsA, dysregulated miR-23a expression contributes to synovial inflammation through enhanced SFC activation, via PDE4B signalling, and identifies a novel anti-inflammatory mechanism of PDE4 blockade.
https://ift.tt/2N7keZj
Early auditory skills development in Mandarin speaking Children after bilateral cochlear implantation
Publication date: Available online 1 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Yue Long, Haihong Liu, Ying Li, Xin Jin, Yi Zhou, Jing Li, Zhipeng Zheng, Peng Liu, Yawen Zhao, Jun Zheng, Jie Zhang, Min Chen, Jinsheng Hao, Yang Yang, Wei Liu
Abstract
Objectives
The purpose of the present study was: (1) to investigate the early auditory preverbal behaviors of infants/toddlers with bilateral cochlear implants (BCI), and to compare their performance with that of unilateral cochlear implant (UCI) peers; (2) to investigate effects of age of implantation, education level of caregivers, living environment, and unaided behavioral threshold before operation on early auditory preverbal development.
Methods
The evaluation material of the present study was the Mandarin version of the LittlEARS® Auditory Questionnaire (LEAQ). Assessments were administrated at 0, 1, 2, 3, 6, 9, 12 and 24 months after cochlear implants (CIs) were switched on. A one-way ANOVA was used to analyze the differences of early auditory preverbal performance between each two contiguous test intervals. A two-sample t test was used to analyze the difference of behaviors between infants/toddlers with BCI and UCI. Non-parametric tests were used to analyze the effects of potential affecting factors on auditory preverbal skills.
Results
Nineteen subjects aging from 9 to 54 months (Mean=22.7, SD=13.7) were recruited in the study. At each evaluation time, the average scores of LEAQ were 4.58, 9.00, 16.00, 18.56, 22.00, 31.50, 29.67, and 34.35 respectively. The total score and semantic auditory behavior score increased significantly during the second months after CIs activation (the total score: LSD-t=3.157, p=0.030; semantic auditory behavior score: LSD-t=1.972, p=0.034). The score of BCI group was significantly higher than UCI group after 1, 3 and 6 months of CI use (1 month: t=3.257, p=0.002; 3 months: t=5.042, p=0.000, 6 months: t=4.054, p=0.000). Education level of caregivers had a positive effect on receptive auditory behavior (H=6.538, p=0.035) after CIs switched on for 3 months. The LEAQ performance was not significantly correlated with pre-operative behavioral threshold although they showed a trend of negative correlation in the first 3 months after activation.
Conclusion
The study indicated that infants and toddlers who underwent BCI had better auditory preverbal skills than their UCI peers. Higher caregivers' education level positively correlated with the early development of auditory preverbal skills. Better pre-operative behavioral threshold might also benefit early auditory preverbal skills development for BCI children.
https://ift.tt/2Nc0R18
A Multidisciplinary International Collaborative Implementing Low Cost, High Fidelity 3D Printed Airway Models To Enhance Ethiopian Anesthesia Resident Emergency Cricothyroidotomy Skills
Publication date: Available online 1 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Virginia T. Gauger, Deborah Rooney, Kevin J. Kovatch, Lauren Richey, Allison Powell, Hailesllassie Berhe, David A. Zopf
Abstract
Background
Similar to other sub-Saharan countries, Ethiopia suffers from a severe shortage of adequately trained health professionals. Academic partnerships can support sustainable training programs and build capacity for low-resource settings. 3D modeling and simulation-based training provide necessary tools, especially for rarely-encountered clinical situations, such as needle cricothyroidotomy.
Methods
Departments of Anesthesiology, Otolaryngology, and Learning Health Sciences collaborated to develop a low-cost, high-fidelity simulator and Cricothryoidotomy Skills Maintenance Program (CSMP). Twelve anesthesia residents at St. Paul's Hospital Medical Millennium College in Addis Ababa, Ethiopia participated in CSMP. The program consisted of a didactic session with presentation and demonstration and an immersive CICO scenario. Program evaluation was performed using pre/post-training knowledge and 2 procedural performance assessments-the CSMP Global Rating Scale and the Checklist. With consent, performances were videotaped and rated independently by 3 University of Michigan faculty.
Results
Improvements were identified in all areas, including residents' knowledge, measured by mean summed test scores, (Mpre=3.31,Mpost=4.46, p=0.003), time to perform cricothyroidotomy (Mpre=96.64,Mpost=72.82,p=0.12), residents' performance quality, measured by overall mean Global ratings, (Mpre=0.20;Mpost=0.70) with improvements identified at the item-level, p=0.001 with moderate-large effect sizes, and residents' ability to complete tasks, measured by mean Checklist ratings (Mpre=0.51,Mpost=0.90, with item-level improvements observed, p≤0.01, with small-large effect sizes. Residents' self-reported confidence also improved, (Mpre=1.69, Mpost=3.08,p=0.001.
Conclusion
Our work shows that cricothyroidotomy skills taught to anesthesia residents at SPHMMC with a 3D printed laryngotracheal model improves knowledge, skills, and confidence. The creation of a low-cost, high-fidelity simulator and a CSMP has the potential to impact patient care and safety world-wide.
https://ift.tt/2CbfTA6
House dust mite‐driven neutrophilic airway inflammation in mice with TNFAIP3‐deficient myeloid cells is IL‐17‐independent
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NFcRFB
Neutrophils induce smooth muscle hyperplasia via neutrophil elastase–induced FGF‐2 in a mouse model of asthma with mixed inflammation
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
https://ift.tt/2oyOIWe
Sweat is a most efficient natural moisturizer providing protective immunity at points of allergen entry
Publication date: Available online 1 September 2018
Source: Allergology International
Author(s): Tetsuo Shiohara, Yoshiko Mizukawa, Yurie Shimoda-Komatsu, Yumi Aoyama
Abstract
Although there is a growing acceptance that sweat could play a detrimental role in various allergic skin diseases, the possibility that sweat is also involved in maintenance of skin hydration and skin-specific immune responses has not been acknowledged. We initially describe physiological role of sweat in both maintaining skin hydration and thermoregulation. The purpose of this article is to provide the reader with objective evidence that sweating is intimately linked to vital stratum corneum barrier function and usefulness of application of moisturizers in clinical care of allergic skin diseases. This review also covers how sweating disturbance would leave the skin vulnerable to the development of various allergic skin diseases, such as atopic dermatitis. New therapeutic approaches would specifically target such sweating disturbance in these allergic skin diseases.
https://ift.tt/2oyis5K
A case of human seminal plasma allergy sensitized with dog prostatic kallikrein, Can f 5
Publication date: Available online 1 September 2018
Source: Allergology International
Author(s): Mari Tanaka, Yukinobu Nakagawa, Yorihisa Kotobuki, Ichiro Katayama
https://ift.tt/2Psvf4K
Differential Cellular Composition of Human Palatine and Pharyngeal Tonsils
Publication date: Available online 1 September 2018
Source: Archives of Oral Biology
Author(s): Luke Stanisce, Etty Sims, Cheryl Hou, Yekaterina Koshkareva, John P. Gaughan, Igor Kuzin, Andrea Bottaro
Abstract
Objective
The goal of this study was to gain a better understanding of the potential functional specialization of palatine and pharyngeal tonsils, by comparing their cellular composition in paired specimens from a large cohort of adenotonsillectomy patients.
Design
Resident B cell, T cell, dendritic cell, and stromal cell subsets were characterized using multicolor flow cytometry in palatine and pharyngeal tonsil specimens from 27 patients, age 2-34 years.
Results
Paired comparisons showed highly significant intra-individual differences in resident cell subsets of palatine and pharyngeal tonsils. Palatine tonsils harbored higher fractions of germinal center B cells/plasmablasts and IgD- CD27- double-negative B cells, and conversely lower fractions of IgD + CD38- resting naïve B cells compared to pharyngeal tonsils. Palatine tonsils also showed lower fractions of plasmacytoid dendritic cells, and higher percentages of two subsets of stromal cells - fibroblastic reticular cells and lymphatic endothelial cells - compared to pharyngeal tonsils from the same individual.
Conclusions
Despite their physical proximity and histological similarities, palatine and pharyngeal tonsils display marked intra-individual differences in their cellular composition with regard to functionally important immune and stromal subsets. These differences are likely to have immunologic, pathologic, and physiologic significance.
https://ift.tt/2Cc388u
Granuloma Annulare’s Triangular Association with Malignancy
Publication date: Available online 1 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Warren R. Heymann
https://ift.tt/2oxrfEK
Diagnostic heuristics in dermatology, Part 2: Metacognition and other fixes
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2LOXusj
Topical resiquimod dosing regimens in patients with multiple actinic keratosis: a multi‐centre, partly placebo‐controlled, double‐blind, clinical trial
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wy5hWI
Assessing the Severity of Pyoderma Gangrenosum – A Need for Validated Measurement Tools
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NDtpxy
Lack of Confidence Interval Reporting in Dermatology: A Call to Action
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wC31xw
Protection of glucotoxicity by a tripeptide derivative of α‐melanocyte‐stimulating hormone in human epidermal keratinocytes
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2LNYBZt
To what extent do disease severity and illness perceptions explain depression, anxiety and quality of life in Hidradenitis Suppurativa
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wy72mQ
Autoantibodies undetectable by chemiluminescent enzyme immunoassay require extended antigen‐antibody reaction time for detection
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2LRhLO9
Diagnostic heuristics in dermatology, Part 2: Metacognition and other fixes
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2LOXusj
Topical resiquimod dosing regimens in patients with multiple actinic keratosis: a multi‐centre, partly placebo‐controlled, double‐blind, clinical trial
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wy5hWI
Assessing the Severity of Pyoderma Gangrenosum – A Need for Validated Measurement Tools
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NDtpxy
Lack of Confidence Interval Reporting in Dermatology: A Call to Action
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wC31xw
Protection of glucotoxicity by a tripeptide derivative of α‐melanocyte‐stimulating hormone in human epidermal keratinocytes
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2LNYBZt
To what extent do disease severity and illness perceptions explain depression, anxiety and quality of life in Hidradenitis Suppurativa
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wy72mQ
Autoantibodies undetectable by chemiluminescent enzyme immunoassay require extended antigen‐antibody reaction time for detection
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2LRhLO9
Reliability of clonidine testing for the diagnosis of growth hormone deficiency in children and adolescents
Clinical Endocrinology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2LPG9zl
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