Head and Neck Diseases by Alexandros G.Sfakianakis: Απριλίου 2016

Κυριακή 24 Απριλίου 2016

ApolipoproteinL1 is expressed in papillary thyroid carcinomas

Publication date: Available online 24 April 2016
Source:Pathology - Research and Practice
Author(s): Mounia Chidiac, Mohammad Fayyad-Kazan, Jalil Daher, Philippe Poelvoorde, Isabelle Bar, Carine Maenhaut, Paul Delrée, Bassam Badran, Luc Vanhamme
The apolipoprotein L (apoL) family has not yet been ascribed any definite patho-physiological function although the conserved BH3 protein domain suggests a role in programmed cell death. As repression of the regular apoptotic program is considered a hallmark of tumor progression, we investigated apoL expression in cancer. We show that the levels of one member of the family, apolipoprotein L1 (apoL1) is higher in papillary thyroid carcinoma compared to normal tissue. A combination of qRTPCR, immunohistochemistry and in situ hybridization allowed us to ascribe this increase to endogenous overexpression in carcinoma cells. Whether apoL1 plays an instrumental role in refraining cell death is the subject of ongoing molecular biology experiments.

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Tooth color change caused by photosensitizers after photodynamic therapy: An in vitro study

Publication date: July 2016
Source:Journal of Photochemistry and Photobiology B: Biology, Volume 160
Author(s): Larissa Menezes Costa, Felipe de Souza Matos, Ayla Macyelle de Oliveira Correia, Nayane Chagas Carvalho, André Luís Faria-e-Silva, Luiz Renato Paranhos, Maria Amália Gonzaga Ribeiro
This study aimed to perform an in vitro evaluation of the effect of photosensitizers used in photodynamic therapy (PDT) on tooth color change when used in combination with conventional endodontic treatment. Forty extracted human mandibular premolars were accessed and underwent root canal therapy and PDT. Photosensitizers were used in accordance with the experimental groups: MB (n=10) — PDT with Methylene Blue at 0.01%; TB (n=10) — PDT with Toluidine Blue at 0.01%; MG (n=10) — PDT with Malachite Green at 0.01%, at the concentration of 0.1mg/mL; and PC (n=10) — positive control, PDT with Endo-PTC cream stained with Methylene Blue at 25%. The samples were irradiated with 660-nm diode laser by means of a 330-μm-diameter optical fiber cable at a power density of 40mW for 120s. After light curing, the photosensitizers were removed from the specimens with 10mL sodium hypochlorite at 1%. A reflectance spectrometer was used for evaluation of color prior to and 60days after the experimental procedure based on the CIE L*a*b* system. According to ANOVA test, there were statistically significant differences between the experimental groups (p=0.003). Tukey's test showed a significant difference between PC and TB (p=0.008), as well as between MG and TB (p=0.009). However, there was no statistically significant difference between PC, MG (p=0.957) and MB (p=0.103). It was concluded that the use of PDT as an adjuvant to root canal therapy, using different photosensitizers, led to color change in tooth structure.

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Synthesis, characterization of new copper (ii) Schiff base and 1,10 phenanthroline complexes and study of their bioproperties

Publication date: July 2016
Source:Journal of Photochemistry and Photobiology B: Biology, Volume 160
Author(s): Pulimamidi Rabindra Reddy, Suryam Rajeshwar, Battu Satyanarayana
Three mononuclear Cu(II) complexes [Cu(naph-phe)phen] (1), [Cu(naph-tyr)(phen)] (2) and [Cu(naph-trp)(phen)] (3) were synthesized, characterized and their biological properties were studied. Complexes 1, 2, 3 exhibit square pyramidal geometry where Schiff base acts as a binegative tridentate ONO donor ligand and phen acts as NN donor ligand. CT-DNA binding studies revealed that the complexes bind through intercalative mode and show good binding propensity. The hydrolytic DNA cleavage activity of these complexes has been studied using gel electrophoresis. The DNA binding and cleavage affinities decrease in the order of 3>2>1. The in-vitro antimicrobial activities of the complexes were also studied.

Graphical abstract

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Editorial Board

Publication date: May 2016
Source:Pathology - Research and Practice, Volume 212, Issue 5

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Editorial Board

Publication date: April 2016
Source:Pathology - Research and Practice, Volume 212, Issue 4

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Monosomy 22 and partial loss of INI1 expression in a biphasic synovial sarcoma with an Ewing sarcoma-like poorly differentiated component: Report of a case

Publication date: Available online 13 April 2016
Source:Pathology - Research and Practice
Author(s): Jasper Bruyneel, Jo Van Dorpe, Marleen Praet, Bart Matthys, Nadine Van Roy, Liesbeth Ferdinande, David Creytens
Poorly differentiated synovial sarcoma (PDSS) is a less common subtype of synovial sarcoma (SS) associated with a poor prognosis. We present a case of a SS with a poorly differentiated component that resembles Ewing sarcoma (ES). Initial immunohistochemical staining revealed a characteristic and strong expression of transducin-like enhancer of split 1 (TLE1) and weak to absent expression of integrase integrator 1 (INI1) staining. Stainings for keratin and epithelial membrane antigen (EMA) were negative in the tumoral lesion. Fluorescence In Situ Hybridization (FISH) analysis showed a rearrangement of the synaptotagmin (SYT) gene, confirming the diagnosis of SS.FISH analysis for the EWS RNA-binding protein 1 (EWSR1) gene revealed monoallelic loss of EWSR1. This finding was confirmed by an array comparative genomic hybridization (aCGH), showing complete loss of chromosome 22.Based on literature review, showing only a handful of cases of cytogenetically studied SS with loss of chromosome 22, this is probably a rare event in SS. Therefore, we assume that monoallelic loss of chromosome 22 cannot fully elaborate the underlying mechanism of the INI1 staining pattern in all SS, but it could account for the weak to absent INI1 staining in at least some cases.

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ApolipoproteinL1 is expressed in papillary thyroid carcinomas

Publication date: Available online 24 April 2016
Source:Pathology - Research and Practice
Author(s): Mounia Chidiac, Mohammad Fayyad-Kazan, Jalil Daher, Philippe Poelvoorde, Isabelle Bar, Carine Maenhaut, Paul Delrée, Bassam Badran, Luc Vanhamme
The apolipoprotein L (apoL) family has not yet been ascribed any definite patho-physiological function although the conserved BH3 protein domain suggests a role in programmed cell death. As repression of the regular apoptotic program is considered a hallmark of tumor progression, we investigated apoL expression in cancer. We show that the levels of one member of the family, apolipoprotein L1 (apoL1) is higher in papillary thyroid carcinoma compared to normal tissue. A combination of qRTPCR, immunohistochemistry and in situ hybridization allowed us to ascribe this increase to endogenous overexpression in carcinoma cells. Whether apoL1 plays an instrumental role in refraining cell death is the subject of ongoing molecular biology experiments.

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The clinical pathological significance of Thy1 and CD49f expression in chondrosarcomas

Publication date: Available online 22 April 2016
Source:Pathology - Research and Practice
Author(s): Lile He, Zhulin Yang, Zhihong Li
ObjectiveThis study investigated the protein expression and clinicopathological significance of Thy1 and CD49f in chondrosarcomas.MethodsThy1 and CD49f protein expression in 59 chondrosarcomas and 33 osteochondromas were measured by immunohistochemical staining.ResultsThe percentage of positive Thy1 and CD49f expression was significantly higher in patients with chondrosarcoma than in patients with osteochondroma (P<0.01). The percentage of positive Thy1 and CD49f expression was significantly lower in patients with histological grade Ⅰ, Enneking stage Ⅰ, AJCC stage Ⅰ/Ⅱ stage, non-metastatic and non-invasive chondrosarcoma than in patients with histological grade Ⅲ, Enneking stage Ⅱ+Ⅲ, AJCC stage Ⅲ/Ⅳ, metastatic and invasive chondrosarcoma (P<0.05 or P<0.01). Thy1 expression was positively correlated with CD49f expression in chondrosarcoma. Kaplan-Meier survival analysis showed that histological grade, AJCC stage, Enneking stage, metastasis, invasion, and Thy1 and CD49f expression significantly correlated with shorter mean survival time in chondrosarcoma patients (P<0.05 or P <0.01). Cox multivariate analysis showed that positive Thy1 and CD49f expression was an independent prognostic factor that negatively correlated with overall postoperative survival.ConclusionPositive Thy1 and CD49f expression is significantly associated with the progression and poor prognosis of chondrosarcoma.

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O-GlcNAcylation is associated with the development and progression of gastric carcinoma

Publication date: Available online 14 April 2016
Source:Pathology - Research and Practice
Author(s): Tae Jung Jang, Ui Jung Kim
IntroductionO-GlcNAcylation occurs via an O-linked β-N-acetylglucosamine (O-GlcNAc) moiety linked to the side chain hydroxyl of a serine or threonine residue on nucleocytoplasmic proteins. This reaction, which is catalyzed by O-GlcNAc-transferase (OGT), is involved in a variety of human cancers; however, its clinical significance in gastric carcinomas (GC) has been poorly investigated in vivo.Materials and methodsImmunohistochemical staining for O-GlcNAcylation and OGT was performed in 64 primary GCs, 40 gastric adenomas and nonneoplastic tissues adjacent to GCs, including 31 tissues of intestinal metaplasia and 24 normal gastric tissues. Their expressions were also studied in 20 tissues of chronic gastritis according to Helicobacter pylori (H. pylori) infection.ResultsO-GlcNAcylation was expressed in the nucleus and both the nuclear rim and cytoplasm. OGT was strongly expressed in the nucleus and weakly expressed in the cytoplasm. O-GlcNAcylation expression levels were significantly correlated with those of OGT. Their expression levels were progressively increased during the carcinogenesis of GC. O-GlcNAcylation expression was higher in GC with intestinal type, higher pT stage and nodal metastasis, while OGT expression was higher in GC with nodal metastasis. Nuclear O-GlcNAcylation expression was more frequently observed in tumors including GC and adenoma than in nonneoplastic tissues including intestinal metaplasia and normal tissue. Nuclear O-GlcNAcylation expression in GC was closely associated with large size, moderate and poor differentiation, higher pT stage, nodal metastasis and higher clinical stage. In addition, the expression of O-GlcNAcylation and OGT was more elevated in H. pylori-infected chronic gastritis than in chronic gastritis without H. pylori infection.ConclusionsO-GlcNAcylation expression and its nuclear expression were associated with the carcinogenesis and progression of GC.

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TWiV 386: The dolphins did it

Hosts: Vincent Racaniello, Rich Condit, and

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Papillary Endothelial Hyperplasia affecting the irradiated breast: A diagnostic dilemma

Publication date: Available online 19 April 2016
Source:Pathology - Research and Practice
Author(s): Laila Khazai, Alec Chau, Susan Hoover, Marilin Rosa
Papillary endothelial hyperplasia (PEH) is a benign proliferative lesion that may occur in any site of the body, but most commonly affects the skin and subcutaneous tissues. In the breast, PEH has been documented but is rare. PEH is notorious for being misdiagnosed as angiosarcoma due to its complex growth pattern, papillary processes and interlacing vascular channels. The occurrence of PEH years after breast irradiation constitutes a pathological and clinical diagnostic challenge because angiosarcoma is far more common in this setting. The most important features that differentiate papillary endothelial hyperplasia from angiosarcoma are its presentation as a round nodule without infiltrative borders, its localization inside a vessel or in association with thrombus, and the lack of significant cytologic atypia or areas of solid growth, even in the presence of a complex architecture. Clinical history and site of involvement (cutaneous versus parenchymal) are usually of help to establish a correct diagnosis. Herein, we described two cases of PEH presenting in patients with history of breast carcinoma and breast radiation therapy. The clinical and morphological features as well as the differential diagnoses are discussed. To our knowledge, no other cases of PEH of the breast occurring in the post-radiation setting have been described in the literature.

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Recurrence and Treatment after Renal Transplantation in Children with FSGS

Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage renal disease and a common pathologic diagnosis of idiopathic nephrotic syndrome (NS), especially in steroid-resistant cases. FSGS is known to recur after kidney transplantation, frequently followed by graft loss. However, not all patients with FSGS suffer from recurrence after kidney transplantation, and genetic and secondary FSGS have a negligible risk of recurrence. Furthermore, many cases of recurrence achieve remission with the current management of recurrence (intensive plasmapheresis/immunosuppression, including rituximab), and other promising agents are being evaluated. Therefore, a pathologic diagnosis of FSGS itself should not cause postponement of allograft kidney transplantation. For patients with a high risk of recurrence who presented with classical symptoms of NS, that is, severe edema, proteinuria, and hypoalbuminemia, close monitoring of proteinuria is necessary, followed by immediate, intensive treatment for recurrence.

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CNS Drugs, Vol. 30, Issue 4 - New Issue Alert

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New Issue Alert

04/24/2016

Dear Alexandros Sfakianakis,

We are pleased to deliver your requested table of contents alert for CNS Drugs. Volume 30 Number 4 is now available online.

In this issue

Leading Article

Targeting Retinoid Receptors to Treat Schizophrenia: Rationale and Progress to Date

Vladimir Lerner, Peter J. A. McCaffery & Michael S. Ritsner

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Review Article

A Review of Pharmacologic Treatment for Compulsive Buying Disorder

Célia Soares, Natália Fernandes & Pedro Morgado

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Review Article

Unexplained Painful Physical Symptoms in Patients with Major Depressive Disorder: Prevalence, Pathophysiology and Management

Jan Jaracz, Karolina Gattner, Krystyna Jaracz & Krystyna Górna

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Original Research Article

The Effect of Gabapentin Enacarbil on Quality of Life and Mood Outcomes in a Pooled Population of Adult Patients with Moderate-to-Severe Primary Restless Legs Syndrome

Alon Y. Avidan, Daniel Lee, Margaret Park, Mark J. Jaros, Gwendoline Shang & Richard Kim

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Original Research Article

Post Hoc Analysis of Potential Predictors of Response to Atomoxetine for the Treatment of Adults with Attention-Deficit/Hyperactivity Disorder using an Integrated Database

Chris Bushe, Esther Sobanski, David Coghill, Lovisa Berggren, Katrien De Bruyckere & Sami Leppämäki

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Adis Drug Evaluation

Brexpiprazole: A Review in Schizophrenia

Karly P. Garnock-Jones

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Adis Drug Evaluation

Lisdexamfetamine: A Review in ADHD in Adults

James E. Frampton

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Erratum

Erratum to: Targeting CGRP: A New Era for Migraine Treatment

Stephanie Wrobel Goldberg & Stephen David Silberstein

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GI stem cells – new insights into roles in physiology and pathophysiology

Abstract

This overview gives a brief historical summary of key discoveries regarding stem cells of the small intestine. The current concept is that there are two pools of intestinal stem cells (ISCs): an actively cycling pool that is marked by Lgr5, is relatively homogeneous and is responsible for daily turnover of the epithelium; and a slowly cycling or quiescent pool that functions as reserve ISCs. The latter pool appears to be quite heterogeneous and may include partially differentiated epithelial lineages that can reacquire stem cell characteristics following injury to the intestine. Markers and methods of isolation for active and quiescent ISC populations are described as well as the numerous important advances that have been made in approaches to the in vitro culture of ISCs and crypts. Factors regulating ISC biology are briefly summarized and both known and unknown aspects of the ISC niche are discussed. Although most of our current knowledge regarding ISC physiology and pathophysiology has come from studies with mice, recent work with human tissue highlights the potential translational applications arising from this field of research. Many of these topics are further elaborated in the following articles.

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Association between Tumor Size and Bilateral Involvement in Papillary Thyroid Carcinoma

Background. Tumor multifocality and bilaterality of papillary thyroid carcinoma (PTC) are important factors when selecting the most appropriate surgical procedure. The aim of this study was to assess the bilaterality rate in PTC and the relationship between the tumor size and bilaterality. Materials and Methods. Thyroidectomy specimens with a diagnosis of PTC were retrospectively reviewed in the Pathology Department of a tertiary care medical center. Specimens were divided into three groups according to the size of the primary and contralateral tumor foci. Tumors less than or equal to 1 cm in each lobe were included in group 1. Group 2 consisted of tumors greater than 1 cm in one lobe and less than 1 cm in the other lobe. Tumors greater than 1 cm in each lobe were included in group 3. Results. We identified 868 total thyroidectomy specimens with a diagnosis of PTC between 2001 and 2011. Of these cases, both thyroid lobes were involved in 262 cases (32%). There were 109 (42%), 121 (46%), and 32 cases (12%) in group 1, group 2, and group 3, respectively. Conclusion. Bilaterality is frequent in PTC and is not related to tumor size. Accordingly, the high frequency of bilateral disease in PTC should be kept in mind when determining the extent of the surgical procedure.

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A Protocol for Bioinspired Design: A Ground Sampler Based on Sea Urchin Jaws

A protocol for bioinspired design is described for a sampling device based on the jaws of a sea urchin. The bioinspiration process includes observing the sea urchins, characterizing the mouthpiece, 3D printing of the teeth and their assembly, and bioexploring the tooth structure.

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GI stem cells – new insights into roles in physiology and pathophysiology

Abstract

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Prevention Science, Vol. 17, Issue 4 - New Issue Alert

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New Issue Alert

04/24/2016

Dear Alexandros Sfakianakis,

We are pleased to deliver your requested table of contents alert for Prevention Science. Volume 17 Number 4 is now available online.

Important news

Adolescent Research Review

Synthesizes and analyzes important contributions to the understanding of youth and adolescence, spanning many allied disciplines. The journal is especially interested in receiving manuscripts that bridge gaps between disciplines or focus on topics that transcend traditional disciplinary boundaries.
» Learn more

In this issue

Technical Assistance to Enhance Prevention Capacity: a Research Synthesis of the Evidence Base

Jason Katz & Abraham Wandersman

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Adaptation and Fidelity: a Recipe Analogy for Achieving Both in Population Scale Implementation

Lynn Kemp

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Understanding and Measuring Coach–Teacher Alliance: A Glimpse Inside the 'Black Box'

Stacy R. Johnson, Elise T. Pas & Catherine P. Bradshaw

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A Test of Outreach and Drop-in Linkage Versus Shelter Linkage for Connecting Homeless Youth to Services

Natasha Slesnick, Xin Feng, Xiamei Guo, Brittany Brakenhoff, Jasmin Carmona, Aaron Murnan, Scottye Cash & Annie-Laurie McRee

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Derivation and Evaluation of a Risk-Scoring Tool to Predict Participant Attrition in a Lifestyle Intervention Project

Luohua Jiang, Jing Yang, Haixiao Huang, Ann Johnson, Edward J. Dill, Janette Beals, Spero M. Manson & Yvette Roubideaux

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Men's Behavior Predicts Women's Risks for HIV/AIDS: Multilevel Analysis of Alcohol-Serving Venues in South Africa

Eileen V. Pitpitan, Seth C. Kalichman, Lisa A. Eaton, Kathleen J. Sikkema, Melissa H. Watt, Donald Skinner & Desiree Pieterse

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Associations Among Excess Weight Status and Tobacco, Alcohol, and Illicit Drug Use in a Large National Sample of Early Adolescent Youth

Meg H. Zeller, Jennifer Becnel, Jennifer Reiter-Purtill, James Peugh & Yelena P. Wu

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Evaluation of the Environmental Supports Scale with a Community Sample of Adolescents

Cristina M. Risco, Anahi D. Collado, Elizabeth K. Reynolds, Carl W. Lejuez & Laura MacPherson

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Development of an Empirically Based Preventive Intervention for Depression in Preadolescent African American Girls

Sophia Duffy, Tasha M. Brown, Tiamo Katsonga-Phiri, Alida Bouris, Kathryn E. Grant & Kate Keenan

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Understanding Associations Between Neighborhood Socioeconomic Status and Negative Consequences of Drinking: a Moderated Mediation Analysis

Katherine J. Karriker-Jaffe, HuiGuo Liu & Lauren M. Kaplan

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Research that Guides Practice: Outcome Research in Swedish PhD Theses Across Seven Disciplines 1997–2012

Tina M. Olsson & Knut Sundell

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ApolipoproteinL1 is expressed in papillary thyroid carcinomas

Tooth color change caused by photosensitizers after photodynamic therapy: An in vitro study

Synthesis, characterization of new copper (ii) Schiff base and 1,10 phenanthroline complexes and study of their bioproperties

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Editorial Board

Publication date: May 2016
Source:Pathology - Research and Practice, Volume 212, Issue 5

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Editorial Board

Publication date: April 2016
Source:Pathology - Research and Practice, Volume 212, Issue 4

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Monosomy 22 and partial loss of INI1 expression in a biphasic synovial sarcoma with an Ewing sarcoma-like poorly differentiated component: Report of a case

ApolipoproteinL1 is expressed in papillary thyroid carcinomas

Publication date: Available online 24 April 2016
Source:Pathology - Research and Practice
Author(s): Mounia Chidiac, Mohammad Fayyad-Kazan, Jalil Daher, Philippe Poelvoorde, Isabelle Bar, Carine Maenhaut, Paul Delrée, Bassam Badran, Luc Vanhamme
The apolipoprotein L (apoL) family has not yet been ascribed any definite patho-physiological function although the conserved BH3 protein domain suggests a role in programmed cell death. As repression of the regular apoptotic program is considered a hallmark of tumor progression, we investigated apoL expression in cancer. We show that the levels of one member of the family, apolipoprotein L1 (apoL1) is higher in papillary thyroid carcinoma compared to normal tissue. A combination of qRTPCR, immunohistochemistry and in situ hybridization allowed us to ascribe this increase to endogenous overexpression in carcinoma cells. Whether apoL1 plays an instrumental role in refraining cell death is the subject of ongoing molecular biology experiments.

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The clinical pathological significance of Thy1 and CD49f expression in chondrosarcomas

Papillary Endothelial Hyperplasia affecting the irradiated breast: A diagnostic dilemma

O-GlcNAcylation is associated with the development and progression of gastric carcinoma

TWiV 386: The dolphins did it

Hosts: Vincent Racaniello, Rich Condit, and

Recurrence and Treatment after Renal Transplantation in Children with FSGS

CNS Drugs, Vol. 30, Issue 4 - New Issue Alert

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New Issue Alert

04/24/2016

Dear Alexandros Sfakianakis,

We are pleased to deliver your requested table of contents alert for CNS Drugs. Volume 30 Number 4 is now available online.

In this issue

Leading Article

Targeting Retinoid Receptors to Treat Schizophrenia: Rationale and Progress to Date

Vladimir Lerner, Peter J. A. McCaffery & Michael S. Ritsner

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Review Article

A Review of Pharmacologic Treatment for Compulsive Buying Disorder

Célia Soares, Natália Fernandes & Pedro Morgado

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Review Article

Unexplained Painful Physical Symptoms in Patients with Major Depressive Disorder: Prevalence, Pathophysiology and Management

Jan Jaracz, Karolina Gattner, Krystyna Jaracz & Krystyna Górna

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Original Research Article

The Effect of Gabapentin Enacarbil on Quality of Life and Mood Outcomes in a Pooled Population of Adult Patients with Moderate-to-Severe Primary Restless Legs Syndrome

Alon Y. Avidan, Daniel Lee, Margaret Park, Mark J. Jaros, Gwendoline Shang & Richard Kim

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Original Research Article

Post Hoc Analysis of Potential Predictors of Response to Atomoxetine for the Treatment of Adults with Attention-Deficit/Hyperactivity Disorder using an Integrated Database

Chris Bushe, Esther Sobanski, David Coghill, Lovisa Berggren, Katrien De Bruyckere & Sami Leppämäki

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Adis Drug Evaluation

Brexpiprazole: A Review in Schizophrenia

Karly P. Garnock-Jones

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Adis Drug Evaluation

Lisdexamfetamine: A Review in ADHD in Adults

James E. Frampton

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Erratum

Erratum to: Targeting CGRP: A New Era for Migraine Treatment

Stephanie Wrobel Goldberg & Stephen David Silberstein

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Impact Factor: 5.113 (2014)
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