Osteoneogenesis due to periosteal elevation with degradable and nondegradable devices in Göttingen Minipigs

Publication date: Available online 31 December 2015
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Dominik Dziewiecki, Sander van de Loo, Felix Gremse, Anita Kloss-Brandstätter, Frank Kloss, Vincent Offermanns, Kensuke Yamauchi, Peter Kessler, Bernd Lethaus
Periosteal distraction or elevation has been known as an experimental method to induce new bone formation. Although it uses the principles of distraction osteogenesis no further osteotomy is necessary. The purpose of this study was to test degradable PDLLA (poly-DL-lactide), PGA (polyglygolic acid) and non degradable (titanium) devices in a calvarian model in Göttingen Minipigs and to evaluate the point of origin of the new bone formation. All degradable devices collapsed to a certain extent within the observation time but osteoneogenesis took place in all materials after a consolidation time of 2, 4 and 6 weeks after implantation above and under the devices. No statistical significant differences between the materials were found. However, most bone formation took place in the space under the periosteum and above the devices (p<0.001). Periosteal elevation can produce new bone formation with degradable devices, which derives from the periosteum and the underlying bone. In this interaction the periosteum seems to contain the larger share.

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YouTube as a source of information on mouth (oral) cancer

Abstract

Objectives

We examined the content of YouTube ™ videos on mouth (oral) cancer, and evaluated their usefulness in promoting early detection of oral cancer.

Material and methods

A systematic search of YouTube ™ for videos containing information on mouth cancer was conducted using the keywords 'mouth cancer' and 'oral cancer'. Demographics of videos, including type, source, length, and viewers' interaction, were evaluated, and three researchers independently assessed the videos for usefulness in promoting early detection of oral cancer.

Results

A total of 188 You Tube ™ videos (152 patient- oriented educational videos and 36testimonial videos) were analyzed. The overall usefulness score ranged from 0 to 10 (mean=3.56 ±2.44). The most useful videos ranked late on the viewing list, and there was no significant correlation between video usefulness and viewing rate, viewers' interaction, and video length. Videos uploaded by individual users were less useful compared to videos uploaded by professional organizations or by health care professionals.

Conclusion

ealth care professionals, academic institutions and professional organizations have a responsibility for improving the content of YouTube ™ about mouth cancer by uploading useful videos, and directing patients to reliable information sources.

This article is protected by copyright. All rights reserved.

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Introducing a protocol to create Bisphosphonate-related osteonecrosis of the jaw in rat animal model

Publication date: Available online 31 December 2015
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Mohammad Zandi, Arash Dehghan, Hamid Malekzadeh, Pejman Janbaz, Khaled Ghadermarzi, Payam Amini
ObjectivePreviously published animal investigations on bisphosphonate-related osteonecrosis of the jaws (BRONJ) showed a variety of methods for BRONJ induction and inconsistent findings. The aim of present study was to develop a reliable protocol for BRONJ induction in rat animal model.Subjects and methodsIn a pilot study, 64 rats were randomly divided into 4 groups and 16 subgroups (each containing 2 experimental and 2 control rats) based on the timing of tooth extraction and euthanasia. The experimental and control rats received intraperitoneal injection of 0.06 mg/kg zoledronate and saline, respectively, once a week until sacrificed, and evaluated for presence of bone exposure clinically, and osteonecrosis and new bone formation histologically. The protocol that successfully produced BRONJ in pilot study was tested in a randomized controlled experimental investigation using 45 rats.ResultsIn pilot investigation, the highest rate of BRONJ was obtained after four weekly zoledronate injections, at least 4 weeks after tooth extraction. The randomized controlled experimental study verified this finding with a success rate of 83%, and also showed that more prolongation of zoledronate therapy did not increase the BRONJ rate.ConclusionThe protocol developed in the present study could be used reliably for future BRONJ investigations on rats.

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YouTube as a source of information on mouth (oral) cancer

Abstract

Objectives

We examined the content of YouTube ^™ videos on mouth (oral) cancer, and evaluated their usefulness in promoting early detection of oral cancer.

Material and methods

A systematic search of YouTube ^™ for videos containing information on mouth cancer was conducted using the keywords 'mouth cancer' and 'oral cancer'. Demographics of videos, including type, source, length, and viewers' interaction, were evaluated, and three researchers independently assessed the videos for usefulness in promoting early detection of oral cancer.

Results

A total of 188 You Tube ^™ videos (152 patient- oriented educational videos and 36testimonial videos) were analyzed. The overall usefulness score ranged from 0 to 10 (mean=3.56 ±2.44). The most useful videos ranked late on the viewing list, and there was no significant correlation between video usefulness and viewing rate, viewers' interaction, and video length. Videos uploaded by individual users were less useful compared to videos uploaded by professional organizations or by health care professionals.

Conclusion

ealth care professionals, academic institutions and professional organizations have a responsibility for improving the content of YouTube ^™ about mouth cancer by uploading useful videos, and directing patients to reliable information sources.

This article is protected by copyright. All rights reserved.

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Osteoneogenesis due to periosteal elevation with degradable and nondegradable devices in Göttingen Minipigs

Publication date: Available online 31 December 2015
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Dominik Dziewiecki, Sander van de Loo, Felix Gremse, Anita Kloss-Brandstätter, Frank Kloss, Vincent Offermanns, Kensuke Yamauchi, Peter Kessler, Bernd Lethaus
Periosteal distraction or elevation has been known as an experimental method to induce new bone formation. Although it uses the principles of distraction osteogenesis no further osteotomy is necessary. The purpose of this study was to test degradable PDLLA (poly-DL-lactide), PGA (polyglygolic acid) and non degradable (titanium) devices in a calvarian model in Göttingen Minipigs and to evaluate the point of origin of the new bone formation. All degradable devices collapsed to a certain extent within the observation time but osteoneogenesis took place in all materials after a consolidation time of 2, 4 and 6 weeks after implantation above and under the devices. No statistical significant differences between the materials were found. However, most bone formation took place in the space under the periosteum and above the devices (p<0.001). Periosteal elevation can produce new bone formation with degradable devices, which derives from the periosteum and the underlying bone. In this interaction the periosteum seems to contain the larger share.



from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1mrsuSD
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

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Introducing a protocol to create Bisphosphonate-related osteonecrosis of the jaw in rat animal model

Publication date: Available online 31 December 2015
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Mohammad Zandi, Arash Dehghan, Hamid Malekzadeh, Pejman Janbaz, Khaled Ghadermarzi, Payam Amini
ObjectivePreviously published animal investigations on bisphosphonate-related osteonecrosis of the jaws (BRONJ) showed a variety of methods for BRONJ induction and inconsistent findings. The aim of present study was to develop a reliable protocol for BRONJ induction in rat animal model.Subjects and methodsIn a pilot study, 64 rats were randomly divided into 4 groups and 16 subgroups (each containing 2 experimental and 2 control rats) based on the timing of tooth extraction and euthanasia. The experimental and control rats received intraperitoneal injection of 0.06 mg/kg zoledronate and saline, respectively, once a week until sacrificed, and evaluated for presence of bone exposure clinically, and osteonecrosis and new bone formation histologically. The protocol that successfully produced BRONJ in pilot study was tested in a randomized controlled experimental investigation using 45 rats.ResultsIn pilot investigation, the highest rate of BRONJ was obtained after four weekly zoledronate injections, at least 4 weeks after tooth extraction. The randomized controlled experimental study verified this finding with a success rate of 83%, and also showed that more prolongation of zoledronate therapy did not increase the BRONJ rate.ConclusionThe protocol developed in the present study could be used reliably for future BRONJ investigations on rats.



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Silent Cancer Therapeutic Market: Segmented By – Type- Tumors, brain, mouth … – Medgadget.com (blog)

Silent Cancer Therapeutic Market: Segmented By – Type- Tumors, brain, mouth … Medgadget.com (blog) logo422 Silent cancer refers to those types of cancer which are undiagnosed in early stages. This is due to asymptomatic nature of the disease which makes it difficult to identify the disease till it progresses to advanced stages. Major silent types of …

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