Lymphatic vessel density and VEGF-C expression as independent predictors of melanoma metastases

In many patients clinical behaviour of cutaneous melanoma is very difficult to predict by traditional histologic and clinical parameters. The aim of this study was to examine the role of quantitative parameters of tumour lymphangiogenesis and vascular endothelial growth factor (VEGF)-C in predicting metastatic risk in patients with cutaneous melanoma.

http://ift.tt/2u2I1R7

Prenatal ultrasound detection of micrognathia and its association with Robin sequence

The antenatal diagnosis of cleft lip from second trimester ultrasound scans is well established1. However it is still not possible to routinely visualise an isolated cleft of the palate (Veau type 1 or 2). In approximately 20-30% of these infants with isolated cleft palate there is an association with Robin sequence. The term refers to the description by Dr Pierre Robin of a cleft of the palate associated with micrognathia, glossoptosis and airway difficulty2. This diagnosis has implications for the immediate management of breathing and feeding.

http://ift.tt/2uBtCs3

The “Nugget Design” – a Modified Segmental Gracilis Free Flap for Small-sized Defect Reconstruction on the Lower Extremity

Little attention has been given to the segmental free gracilis muscle flap supplied by secondary proximal pedicles. We introduce a technical refinement for small-sized three-dimensional defect reconstruction on the foot.

http://ift.tt/2u2zSMC

Sentinel lymph node biopsy for external ear melanoma: a 17 year experience with long term survival data

Melanoma of the external ear is an uncommon tumour, sparsely reported, with contrasting data regarding its prognosis.1 A recent letter from the Department of Plastic Surgery at St George's Hospital, London 2 has suggested that external ear melanoma has a lower rate of sentinel lymph node positivity which might correlate with a favourable outcome, but these data did not reach statistical significance. The study lacked long term survival data which the authors suggested was important to further interpret this result.

http://ift.tt/2uBJF95

The effectiveness of botulinum toxin A injection for the treatment of secondary axillary bromhidrosis

Surgical removal of apocrine glands is a valid treatment option for axillary bromhidrosis. However, malodor may recur after the operation. The value of botulinum toxin A (BTX-A) injection in the treatment of secondary axillary bromhidrosis was investigated in the present study. From July of 2012 to May of 2016, 53 patients with secondary axillary bromhidrosis were enrolled in our clinic. Various BTX-A injection strategies were applied depending on different types of previous surgery. None of the patients reported adverse side effects after the procedure.

http://ift.tt/2uBHhQ3

STAT6 Reliably Distinguishes Solitary Fibrous Tumors from Myofibromas

Abstract

Solitary fibrous tumors (SFT) and myofibromas (MF) historically have belonged to the same morphologic spectrum and have been lumped together under the nonspecific umbrella term, "hemangiopericytoma" along with other pericytic/myoid tumors. While current evidence shows clear distinction between the two entities, they frequently remain in the same histopathologic differential diagnosis. This diagnostic dilemma especially is common for smaller incisional biopsies from the oral cavity. STAT6 immunohistochemistry (IHC) recently was established as a reliable method to detect solitary fibrous tumor; however, the literature is sparse regarding STAT6 reactivity in MFs. The authors report ten new cases of oral solitary fibrous tumor, discuss histopathologic similarities and differences between the two tumors, and list respective STAT6 IHC expressivity. After IRB approval, 10 cases diagnosed as SFT and 24 cases of MF were collected from the University of Florida Oral and Maxillofacial Pathology Biopsy Service between the years 1994 and 2016. The original hematoxylin and eosin slides and related IHC were reviewed. IHC with STAT6 antibody was performed on all 34 samples, and the findings were analyzed. All cases were from the oral cavity or perioral regions. 10/10 SFTs expressed STAT6 nuclear reactivity, while no cases of MF showed nuclear expression of STAT6. STAT6 is a dependable marker to differentiate SFTs from MFs.

http://ift.tt/2tTg9hP

STAT6 Reliably Distinguishes Solitary Fibrous Tumors from Myofibromas

Abstract

Solitary fibrous tumors (SFT) and myofibromas (MF) historically have belonged to the same morphologic spectrum and have been lumped together under the nonspecific umbrella term, "hemangiopericytoma" along with other pericytic/myoid tumors. While current evidence shows clear distinction between the two entities, they frequently remain in the same histopathologic differential diagnosis. This diagnostic dilemma especially is common for smaller incisional biopsies from the oral cavity. STAT6 immunohistochemistry (IHC) recently was established as a reliable method to detect solitary fibrous tumor; however, the literature is sparse regarding STAT6 reactivity in MFs. The authors report ten new cases of oral solitary fibrous tumor, discuss histopathologic similarities and differences between the two tumors, and list respective STAT6 IHC expressivity. After IRB approval, 10 cases diagnosed as SFT and 24 cases of MF were collected from the University of Florida Oral and Maxillofacial Pathology Biopsy Service between the years 1994 and 2016. The original hematoxylin and eosin slides and related IHC were reviewed. IHC with STAT6 antibody was performed on all 34 samples, and the findings were analyzed. All cases were from the oral cavity or perioral regions. 10/10 SFTs expressed STAT6 nuclear reactivity, while no cases of MF showed nuclear expression of STAT6. STAT6 is a dependable marker to differentiate SFTs from MFs.

http://ift.tt/2tTg9hP