Bimatoprost ophthalmic solution in facial vitiligo

Summary

Background

Vitiligo is one of the commonest pigmentary disorders characterized by destruction of melanocytes.

Aim

To evaluate the efficacy of topical bimatoprost ophthalmic solution in stable facial vitiligo.

Material and methods

Eight cases of stable facial vitiligo were treated with bimatoprost 0.03% ophthalmic solution once daily for 12 weeks. Photographic records were taken at 2 weeks follow-up along with dermoscopic (Polarized, 10×) evaluation.

Results

Four cases had excellent repigmentation, two cases had partial repigmentation and two cases had poor response.

Conclusion

Bimatoprost seems to be promising in treating stable vitiligo but large-scale studies are required.

http://ift.tt/2yrn8QR

Bimatoprost ophthalmic solution in facial vitiligo

Summary

Background

Vitiligo is one of the commonest pigmentary disorders characterized by destruction of melanocytes.

Aim

To evaluate the efficacy of topical bimatoprost ophthalmic solution in stable facial vitiligo.

Material and methods

Eight cases of stable facial vitiligo were treated with bimatoprost 0.03% ophthalmic solution once daily for 12 weeks. Photographic records were taken at 2 weeks follow-up along with dermoscopic (Polarized, 10×) evaluation.

Results

Four cases had excellent repigmentation, two cases had partial repigmentation and two cases had poor response.

Conclusion

Bimatoprost seems to be promising in treating stable vitiligo but large-scale studies are required.

http://ift.tt/2yrn8QR

Two case reports of desensitization in patients with hypersensitivity to iron

Iron deficiency anemia is a disease that can significantly compromise a patient's quality of life. Desensitization is a safe and effective treatment option for iron-deficient anemic patients who require intrav...

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Checklist for a complete chronic urticaria medical history: an easy tool

Existing guidelines do not offer a quick, efficient alternative to the patient's recollection of relevant clinical features during anamnesis and physical examination for chronic urticaria (CU). This study aime...

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Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future

In today's clinical practice patients' skin is used as screening organ for diagnosing type 1 allergy. According to European guidelines skin prick testing with a panel of 18 allergen extracts is recommended, in...

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Debates in Allergy Medicine: Allergy skin testing cannot be replaced by molecular diagnosis in the near future

Percutaneous skin prick tests (SPT) have been considered the preferred method for confirming IgE-mediated sensitization. This reliable and minimally invasive technique correlates with in vivo challenges, has g...

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Review: Diagnosing Common Variable Immunodeficiency Disorder in the Era of Genome Sequencing

Abstract

Common variable immunodeficiency disorders (CVID) are an enigmatic group of often heritable conditions, which may manifest for the first time in early childhood or as late as the eighth decade of life. In the last 5 years, next generation sequencing (NGS) has revolutionised identification of genetic disorders. However, despite the best efforts of researchers around the globe, CVID conditions have been slow to yield their molecular secrets. We have previously described the many clinical advantages of identifying the genetic basis of primary immunodeficiency disorders (PIDs). In a minority of CVID patients, monogenic defects have now been identified. If a causative mutation is identified, these conditions are reclassified as CVID-like disorders. Here we discuss recent advances in the genetics of CVID and discuss how NGS can be optimally deployed to identify the causal mutations responsible for the protean clinical manifestations of these conditions. Diagnostic criteria such as the Ameratunga et al. criteria will continue to play an important role in patient management as well as case selection and sequencing strategy design until the genetic conundrum of CVID is solved.

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