[Europe and Japan alliance for clinical research in oncology].

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[Europe and Japan alliance for clinical research in oncology].

Bull Cancer. 2018 Jan 20;:

Authors: Evrard S

PMID: 29366499 [PubMed - as supplied by publisher]

http://ift.tt/2EaEL8o

Forestier syndrome and obstructive sleep apnea: Surgical treatment.

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Forestier syndrome and obstructive sleep apnea: Surgical treatment.

Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Jan 20;:

Authors: Ribeiro DK, Pinto JA, Freitas GS

Abstract
INTRODUCTION: We report a case of obstructive sleep apnea that occurred as a result of Forestier disease and describe the surgical treatment that was performed.
SUMMARY: The patient is a 56-year-old man who presented dysphagia for solids and liquids, snoring (score 10) and excessive daytime sleepiness for 5 years. On fiber optic laryngoscopy examination, there was interarytenoid edema and protrusion of the posterior wall of the larynx. The cervical X-Ray showed protrusion of intervertebral disc between C3-C5 (skeletal hyperostosis) and the polysomnography revealed apnea-hypopnea index (AHI) of 56 events/h. Surgery was performed by the otorhinolaryngology and orthopedic teams. The patient evolved with complete symptom resolution and an AHI of 3,9 events/h on the control polysomnography.
DISCUSSIONS: This is the first reported case of Forestier Syndrome (FS) associated with Obstructive Sleep Apnea (OSA) that was proposed surgical treatment and the patient evolved with complete symptom improvement.

PMID: 29366867 [PubMed - as supplied by publisher]

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Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.

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Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.

Nature. 2017 08 30;548(7669):592-596

Authors: Kikuchi T, Morizane A, Doi D, Magotani H, Onoe H, Hayashi T, Mizuma H, Takara S, Takahashi R, Inoue H, Morita S, Yamamoto M, Okita K, Nakagawa M, Parmar M, Takahashi J

Abstract
Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to treat Parkinson's disease (PD), in which midbrain dopaminergic neurons progressively degenerate. However, long-term analysis of human iPS cell-derived dopaminergic neurons in primate PD models has never been performed to our knowledge. Here we show that human iPS cell-derived dopaminergic progenitor cells survived and functioned as midbrain dopaminergic neurons in a primate model of PD (Macaca fascicularis) treated with the neurotoxin MPTP. Score-based and video-recording analyses revealed an increase in spontaneous movement of the monkeys after transplantation. Histological studies showed that the mature dopaminergic neurons extended dense neurites into the host striatum; this effect was consistent regardless of whether the cells were derived from patients with PD or from healthy individuals. Cells sorted by the floor plate marker CORIN did not form any tumours in the brains for at least two years. Finally, magnetic resonance imaging and positron emission tomography were used to monitor the survival, expansion and function of the grafted cells as well as the immune response in the host brain. Thus, this preclinical study using a primate model indicates that human iPS cell-derived dopaminergic progenitors are clinically applicable for the treatment of patients with PD.

PMID: 28858313 [PubMed - indexed for MEDLINE]

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"Ann Plast Surg"[jour]; +26 new citations

26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

"Ann Plast Surg"[jour]

These pubmed results were generated on 2018/01/26

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

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"Int J Surg"[jour]; +18 new citations

18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

"Int J Surg"[jour]

These pubmed results were generated on 2018/01/26

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

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Rhizospheric effects on the microbial community of e-waste-contaminated soils using phospholipid fatty acid and isoprenoid glycerol dialkyl glycerol tetraether analyses

Abstract

We performed the study of rhizospheric effects on soil microbial community structure, including bacteria, fungi, actinomycete, and archaea, at an electronic waste (e-waste) recycling site by analyzing the phospholipid fatty acid (PLFA) and isoprenoid glycerol dialkyl glycerol tetraether (GDGT) contents. By comparing PLFA and isoprenoid GDGT profiles of rhizospheric and surrounding bulk soils of 11 crop species, we observed distinct microbial community structures. The total PLFA concentration was significantly higher in rhizospheric soils than in non-rhizospheric soils, whereas no obvious difference was found in the total isoprenoid GDGT concentrations. The microbial community structure was also different, with higher ratios of fungal-to-bacterial PLFAs (F/B) and lower relative abundance of Gram-positive bacteria in rhizospheric soils. The extent of rhizospheric effects varied among plant species, and Colocasia esculenta L. had the greatest positive effects on the total microbial biomass. Dissolved organic carbon and pH were the main environmental factors affecting the microbial community represented by PLFAs, while the archaeal community was influenced by copper and zinc in all soils. These results offer a comprehensive view of rhizospheric effects on microbes in heavy metal and persistent organic pollutant co-contaminated soil, and provide fundamental knowledge regarding microbial ecology in e-waste-contaminated soils.

http://ift.tt/2Bv8oyp

Two novel microRNA biomarkers related to β-cell damage and their potential values for early diagnosis of type 1 diabetes.

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Two novel microRNA biomarkers related to β-cell damage and their potential values for early diagnosis of type 1 diabetes.

J Clin Endocrinol Metab. 2018 Jan 23;:

Authors: Liu L, Yan J, Xu H, Zhu Y, Liang H, Pan W, Yao B, Han X, Ye J, Weng J

Abstract
Context: New strategies and biomarkers are needed in the early detection of β-cell damage in the progress of type 1 diabetes mellitus (T1DM).
Objective: To explore whether serum microRNAs should be served as biomarkers for T1DM.
Design, Settings and Patients: The serum microRNA profile was established with microRNA microarray in discovery phase (6 T1DM, 6 controls). A microRNA-based model for T1DM diagnosis was developed using logistic regression analysis in the training dataset (40 T1DM, 56 controls) and then validated with leave-one-out cross validation and another independent validation dataset (33 T1DM, 29 controls).
Main Outcome Measure(s): Quantitative RT-PCR was applied to confirm the differences of candidate microRNAs between T1DM and controls. Area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. INS-1 cells, streptozocin-treated mice (n=4) and NOD mice (n=12) were used to evaluate the association of microRNAs with β-cell damage.
Results: A microRNA-based model was established in the training dataset with high diagnostic accuracy for T1DM (AUC=0.817) based on six candidate differential expressed microRNAs identified in discovery phase. The validation dataset showed the model's satisfactory diagnostic performance (AUC=0.804). Secretions of miR-1225-5p and miR-320c were significantly increased in streptozocin-treated mice and INS-1 cells. Noteworthy, the elevation of these two microRNAs was observed before glucose elevation in the progress of diabetes in NOD mice.
Conclusions: Two microRNA biomarkers (miR-1225-5p and miR-320c) related to β-cell damage were identified in recent-onset T1DM patients. The microRNA-based model established in this study exhibited a good performance in diagnosis of T1DM.

PMID: 29370422 [PubMed - as supplied by publisher]

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