Efficacy of neurokinin-1 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting in patients receiving carboplatin-based chemotherapy: A systematic review and meta-analysis

Publication date: April 2018
Source:Critical Reviews in Oncology/Hematology, Volume 124
Author(s): Massimo Di Maio, Chiara Baratelli, Paolo Bironzo, Francesca Vignani, Emilio Bria, Elisa Sperti, Maddalena Marcato, Fausto Roila
According to current ESMO – MASCC guidelines, a combination of a neurokinin-1 receptor antagonist (NK1RA), dexamethasone and a 5-HT3 receptor antagonist (5-HT3RA) is recommended to prevent carboplatin-induced emesis, albeit with moderate level of confidence and not unanimous consensus. We performed a meta-analysis of randomized trials (RCTs) comparing NK1RA + dexamethasone + 5-HT3RA vs. dexamethasone + 5-HT3RA in patients receiving the first cycle of carboplatin-based chemotherapy. Primary outcome was complete response (CR), defined as no emesis and no use of rescue medication. 9 trials were eligible, and data of CR were available from 8 trials (1598 patients). Addition of NK1RA improves CR in all phases: acute phase, 94.5% vs. 90.1%; delayed phase, 76.4% vs. 61.7%; overall period, 75.3% vs. 60.4%. There was no significant heterogeneity among trials. In patients receiving carboplatin-based chemotherapy, the addition of NK1RA to dexamethasone and 5-HT3RA is associated with a statistically significant and clinically relevant improvement in CR.



http://ift.tt/2H5f22g

Dataset on predictive compressive strength model for self-compacting concrete

Publication date: Available online 9 February 2018
Source:Data in Brief
Author(s): O.M. Ofuyatan, S.O. Edeki
The determination of compressive strength is affected by many variables such as the water cement (WC) ratio, the superplasticizer (SP), the aggregate combination, and the binder combination. In this dataset article, 7, 28, and 90-day compressive strength models are derived using statistical analysis. The response surface methodology is used toinvestigate the effect of the parameters: Varying percentages of ash, cement, WC, and SP on hardened properties-compressive strengthat 7,28 and 90 days. Thelevels of independent parameters are determinedbased on preliminary experiments. The experimental values for compressive strengthat 7, 28 and 90 days and modulus of elasticity underdifferent treatment conditions arealso discussed and presented.These dataset can effectively be used for modelling and prediction in concrete production settings.



http://ift.tt/2Ee49ct

Measured and Estimated data of Non-linear BRAN Channels Using HOS in 4G Wireless Communications

Publication date: Available online 10 February 2018
Source:Data in Brief
Author(s): Mohammed Zidane, Said Safi, Mohamed Sabri
The aim of this research is to develop a non-linear blind estimator able to represents a Broadband Radio Access Networks (BRAN) channels. In the one hand, we have used Higher Order Statistics (HOS) theory to build our algorithm. Indeed, we develop a non-linear method based only on fourth order cumulants for identifying the diagonal parameters of quadratic systems. In the other hand, the developed approach is applied to estimate the experimental channels, BRAN A, C and E data normalized for MC-CDMA, in non-linear case. However, the estimated data will be used in the blind equalization. The simulation results in noisy environment and for different signal to noise ratio (SNR) show the accuracy of develop estimator blindly (i.e., without any information about the input) with non-Gaussian signal input. Furthermore, in part of blind equalization problem the obtained results, using Zero forcing (ZF) and Minimum Mean Square Error (MMSE) equalizers, demonstrate that the proposed algorithm is very adequate to correct channel distortion in term the Bit Error Rate (BER). Finally, these estimated data present a necessary asset for conducting validation experiments, and can be also used as a baseline.



http://ift.tt/2EXfVcJ

Survey datasets on Women participation in Green jobs in the Construction Industry

Publication date: Available online 9 February 2018
Source:Data in Brief
Author(s): Adedeji O. Afolabi, Rapheal A. Ojelabi, Patience F. Tunji-Olayeni, Olabosipo I. Fagbenle, Timothy O. Mosaku
The unique qualities of women can make them bearers of solutions towards achieving sustainability and dealing with the dangers attributed to climate change. The attitudinal study utilized a questionnaire instrument to obtain perception of female construction professionals. By using a well-structured questionnaire, data was obtained on women participating in green jobs in the construction Industry. Descriptive statistics is performed on the collected data and presented in tables and mean scores (MS). In addition, inferential statistics of categorical regression was performed on the data to determine the level of influence (beta factor) the identified barriers had on the level of participation in green jobs. Barriers and the socio-economic benefits which can guide policies and actions on attracting, retaining and exploring the capabilities of women in green jobs can be obtained from the survey data when analyzed.



http://ift.tt/2EgzRG5

Immunology of the Uterine and Vaginal Mucosae

Publication date: Available online 9 February 2018
Source:Trends in Immunology
Author(s): Jordan Z. Zhou, Sing Sing Way, Kang Chen
Along with the maintenance of symbiotic mutualism with commensal microbes and protection against invasive infections common to all mucosal barrier tissues, female reproductive tissues have additional, unique tasks that include dynamic cyclic cellular turnover in menstruation and immunological tolerance to genetically foreign fetal antigens in pregnancy. Here we review current knowledge on distinct features of the immune cells in female reproductive tissue with regard to antimicrobial host defense and adaptations to accommodate the fetus during pregnancy. Outstanding areas for future research to obtain new functional insights on this enigmatic mucosal barrier are also highlighted.



http://ift.tt/2EV957y

Editorial Board

Publication date: February 2018
Source:Clinical Therapeutics, Volume 40, Issue 2





http://ift.tt/2H58RLM

Table of Contents

Publication date: February 2018
Source:Clinical Therapeutics, Volume 40, Issue 2





http://ift.tt/2G4qJon