Bullous complex regional pain syndrome: A description of the clinical and histopathologic features

Journal of Cutaneous Pathology, EarlyView.


https://ift.tt/2sg7uns

Effects of Progressive Additional Lenses on Binocular Vision in Children with Pseudophakia

Binocular vision may be compromised in children after unilateral cataract surgery because the distances at which clear vision is present are different for the two eyes. We believe that wearing progressive additional lenses can be effective in improving the binocular vision in children with pseudophakia.
Case Rep Ophthalmol 2018;9:304–309

https://ift.tt/2xnlalv

A reply to Sahle and Braun's reply to ‘The pattern of emergence of a Middle Stone Age tradition at Gademotta and Kulkuletti (Ethiopia) through convergent tool and point technologies’ [J. Hum. Evol. 91 (2016) 93–121]

Publication date: Available online 28 May 2018
Source:Journal of Human Evolution
Author(s): Katja Douze, Anne Delagnes, Veerle Rots, Brad Gravina
Sahle and Braun's (in press) recent comments on our identification (Douze and Delagnes, 2016) of diachronic trends in Middle Stone Age point traditions in several lithic assemblages from the sites of Gademotta and Kulkuletti (Ethiopia) focuses on pointed tool function rather than the gradual technological shifts we observed between sites. Here we address several of what we consider to be inaccuracies and misinterpretations concerning our work with the Gademotta and Kulkuletti lithic assemblages (Douze, 2012, 2014), more specifically, Sahle and Braun's (in press) interpretation of the tranchet blow technique. This discussion is inseparable from a critical review of the evidence advanced by Sahle and Braun to support projectile technology being present in the Gademotta Formation as early as >279 ka.



https://ift.tt/2IREahv

Establishment of adoptive cell therapy with tumor infiltrating lymphocytes for non-small cell lung cancer patients

Abstract

Adoptive cell therapy (ACT) of tumor infiltration lymphocytes (TIL) yields promising clinical results in metastatic melanoma patients, who failed standard treatments. Due to the fact that metastatic lung cancer has proven to be susceptible to immunotherapy and possesses a high mutation burden, which makes it responsive to T cell attack, we explored the feasibility of TIL ACT in non-small cell lung cancer (NSCLC) patients. Multiple TIL cultures were isolated from tumor specimens of five NSCLC patients undergoing thoracic surgery. We were able to successfully establish TIL cultures by various methods from all patients within an average of 14 days. Fifteen lung TIL cultures were further expanded to treatment levels under good manufacturing practice conditions and functionally and phenotypically characterized. Lung TIL expanded equally well as 103 melanoma TIL obtained from melanoma patients previously treated at our center, and had a similar phenotype regarding PD1, CD28, and 4-1BB expressions, but contained a higher percent of CD4 T cells. Lung carcinoma cell lines were established from three patients of which two possessed TIL cultures with specific in vitro anti-tumor reactivity. Here, we report the successful pre-clinical production of TIL for immunotherapy in the lung cancer setting, which may provide a new treatment modality for patients with metastatic NSCLC. The initiation of a clinical trial is planned for the near future.

https://ift.tt/2kvptSF

Caged nanoparticles boost catalytic power

Publication date: June 2018
Source:Nano Today, Volume 20





https://ift.tt/2IWTdCy

Editorial Board

Publication date: June 2018
Source:Nano Today, Volume 20





https://ift.tt/2LEYTCN

Impact of a static magnetic field on biodegradation of wastewater compounds and bacteria recombination

Abstract

The current study presents results concerning the effect of a static magnetic field (SMF) on synthetic wastewater biodegradation by activated sludge and on dehydrogenase activity of microorganisms of activated sludge. The highest process efficiency was obtained for a SMF of 0.0075 T among the tested magnetic flux density values of 0.005–0.14 T. Decrease in COD was 25% higher for the bioreactor exposed to SMF compared with control experiments. The positive effect of SMF 0.0075–0.0080 T was confirmed in experiments on the dehydrogenase activity of activated sludge. It was also shown that a SMF of 0.007 T increased p-nitroaniline removal from wastewater and influenced the recombination frequency in a streptomycin-resistant bacteria strain of Eschercihia coli.

https://ift.tt/2LDCkOQ