LA-ICP-MS U-Pb zircon geochronology data of the Early to Mid-Miocene syn-extensional massive silicic volcanism in the Pannonian Basin (East-Central Europe)

Publication date: August 2018
Source:Data in Brief, Volume 19
Author(s): Réka Lukács, Marcel Guillong, Jakub Sliwinski, István Dunkl, Olivier Bachmann, Szabolcs Harangi
This article provides LA-ICP-MS in-situ U-Pb zircon dates performed on single crystals from dacitic to rhyolitic ignimbrites of the Bükkalja Volcanic Field (Hungary, East-Central Europe) temporally covering the main period of the Neogene silicic volcanic activity in the Pannonian Basin. The data include drift-corrected, alpha dose-corrected, Th-disequilibrium-corrected, and filtered data for geochronological use. The data presented in this article are interpreted and discussed in the research article entitled "Early to Mid-Miocene syn-extensional massive silicic volcanism in the Pannonian Basin (East-Central Europe): eruption chronology, correlation potential and geodynamic implications" by Lukács et al. (2018) [1].



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Metagenomic data on Anadara granosa associated bacterial communities using culture dependent approaches and 16S rRNA sequencing

Publication date: August 2018
Source:Data in Brief, Volume 19
Author(s): Kamarul Zaman Zarkasi, Mardani Abdul Halim, Teh Faridah Nazari, Feizal Daud
This article contains data on the bacterial communities and its diversity associated with Anadara granosa. The A. granosa samples were obtained from two major estuaries in Penang, Malaysia using a culture dependent and 16S rRNA Illumina sequencing approaches. A. granosa, a commercial blood cockles and popular seafoods, is fragile to the surrounding environments. Thus, our research focused to better understand the bacterial communities and it diversity in the A. granosa, as well as on the generation of a metagenomic library from A. granosa to further understanding on it diversity. The bacteria Vibrionaceae (34.1%) was predominant in the A. granosa from both environments followed by Enterobacteriaceae (33.3%) and Bacillaceae (16.75%). Vibrio sp., Klebsiella sp., and Bacillus subtilis were the most abundant species present. The data generated in this research is the first metagenomic examination of A. granosa and will provide as a baseline to understand the bacterial communities associated with A. granosa and its surrounding natural environments.



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Dataset and analysis of editorial board composition of 165 Hindawi journals indexed and abstracted in PubMed based on affiliations

Publication date: August 2018
Source:Data in Brief, Volume 19
Author(s): Hilary I. Okagbue, Aderemi A. Atayero, Muminu O. Adamu, Pelumi E. Oguntunde, Abiodun A. Opanuga, Sheila A. Bishop
This article explores the editorial board composition (across the six continents) of Hindawi journals indexed in PubMed. The dataset used is the official affiliation of the board members available at the various webpages of Hindawi journal website and not the countries of origin of the editorial board members. Summary statistics were presented and the raw dataset was provided for further analysis by interested scholars. The percentage of the editorial board composition across the continents was presented, the dataset of Hindawi journals indexed in both Hindawi and Scopus were also presented and measured in terms of Citescore and percentiles. The dataset can be used in journal evaluation, auditing, bibliometric analysis, management of smart campus; ranking and the analysis can be extended to other journal indexations.



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Microbes and Infection turns 20

Publication date: Available online 30 May 2018
Source:Microbes and Infection
Author(s): Sophia J. Häfner, David M. Ojcius
The journal Microbes and Infection is celebrating its vigintennial anniversary and has reunited for this occasion two dozen reviews illustrating achievements of the past as well as future challenges in the field of infectious diseases. From top-notch vaccine development strategies, to high-throughput powered analysis of complex host-pathogen interactions, to innovative therapeutic designs, this issue covers the entire spectrum of pathogens and areas of their confrontation with the host.



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Emerging Trends in Biomarker Discovery: Ease of Prognosis and Prediction in Cancer

Publication date: Available online 29 May 2018
Source:Seminars in Cancer Biology
Author(s): Anil K. Sharma




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Implementing Precision Cancer Medicine in the Genomic Era

Publication date: Available online 30 May 2018
Source:Seminars in Cancer Biology
Author(s): Hui-Zi Chen, Russell Bonneville, Sameek Roychowdhury
The utilization of genomic data to direct treatment for cancer patients represents the central tenet in precision oncology, in which a patient is matched to a specific drug or therapy based on the genetic drivers detected in his or her tumor rather than the tumor's histologic classification. The expected but not always realized outcomes of molecularly matched therapies include increased response rates, more durable responses, deeper responses, and decreased number of therapy-related side effects. In this review, we will discuss different facets of utilizing genomic data to direct the increasingly complex care of cancer patients. We discuss the enlarging compendium of actionable genomic alterations and the development of novel molecular diagnostic assays for clinical application. Finally, we present an overview of the growing number of genomics-driven clinical trials and conclude with a discussion of future challenges in the implementation of precision oncology.



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Highly sensitive electrochemiluminescence immunosensor based on ABEI/H2O2 system with PFO dots as enhancer for detection of kidney injury molecule-1

Publication date: 30 September 2018
Source:Biosensors and Bioelectronics, Volume 116
Author(s): Huiyun Yang, Haijun Wang, Chengyi Xiong, Yaqin Chai, Ruo Yuan
In this work, poly[9,9-dioctylfluorenyl-2,7-diyl] (PFO) dots is discovered to display an appealing dual enhancement effect for the electrochemiluminescence (ECL) system of N-(aminobutyl)-N-(ethylisoluminol)/hydrogen peroxide (ABEI/H2O2), which not only enhances the ECL intensity of ABEI but also catalyzes decomposition of H2O2 to further amplify the ECL signal of ABEI. Owing to the electronegative property of PFO dots, electropositive ABEI-PEI as ECL reagent could be adsorbed on their surface and thus form a novel luminescence emitter (ABEI-PEI-PFO dots) with high ECL efficiency based on electrostatic attraction. Meanwhile, the water solubility and stability of this emitter are improved in virtue of the amine-rich property of ECL reagent (ABEI-PEI), which could increase the luminous efficiency of ECL reaction in aqueous solution. To increase the electron transfer efficiency, Pt nanoparticles (PtNPs) supported on reduced graphene oxide nanosheets (RGOs) via a onepot synthetic strategy are chosen as immobilizing platform for the ECL emitter (ABEI-PEI-PFO dots). Herein, the obtained dual-amplifed ABEI-PEI-PFO dots-RGOs/PtNPs complex is served as an ideal nanocarrier to capture detection antibody (Ab2). According to sandwiched immunoreaction, a highly sensitive ECL immunosensor is constructed for the detection of kidney injury molecule-1 (KIM-1) with a linearity from 50 fg mL⁻¹ to 1 ng mL⁻¹ and a detection limit of 16.7 fg mL⁻¹. The developed ECL emitter combining dual amplified property for signal enhancement purpose would provide new thought and potential for sensitive bioanalysis and clinical application.



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