Cervical-Cranial Dry Needling vs. Orthopedic Manual Therapy for Cervicogenic Headache

Condition:   Cervicogenic Headache
Interventions:   Other: Cervical-cranial dry needling;   Other: Orthopedic manual therapy;   Other: Thoracic Manipulation;   Other: Exercise;   Other: Patient Education
Sponsors:   Youngstown State University;   Franklin Pierce University
Not yet recruiting

https://ift.tt/2LbaKrE

Efficacy of Physiotherapy in Patients With Bruxism.

Condition:   Temporomandibular Dysfunction (TMD)
Interventions:   Other: Manual therapy;   Other: Regular treatment control.
Sponsor:   University of Valencia
Recruiting

https://ift.tt/2NKz6do

Cervical-Cranial Dry Needling vs. Orthopedic Manual Therapy for Cervicogenic Headache

Condition:   Cervicogenic Headache
Interventions:   Other: Cervical-cranial dry needling;   Other: Orthopedic manual therapy;   Other: Thoracic Manipulation;   Other: Exercise;   Other: Patient Education
Sponsors:   Youngstown State University;   Franklin Pierce University
Not yet recruiting

https://ift.tt/2LbaKrE

Efficacy of Physiotherapy in Patients With Bruxism.

Condition:   Temporomandibular Dysfunction (TMD)
Interventions:   Other: Manual therapy;   Other: Regular treatment control.
Sponsor:   University of Valencia
Recruiting

https://ift.tt/2NKz6do

Increased risk of incident psoriasis in end‐stage renal disease patients on chronic hemodialysis: A nationwide population‐based cohort study

The Journal of Dermatology, EarlyView.


https://ift.tt/2L8TUJW

Fulminant onset of insulin-dependent diabetes with positive anti-GAD antibody titers during treatment with nivolumab in a patient with NSCLC

Abstract

Programmed cell death-1 (PD-1) and programmed cell death-ligand-1 (PD-L1) inhibitors have been highlighted in the field of cancer treatment. The interaction between PD-1 and PD-L1 is thought to play an important role in the regulation of the self-immune tolerance mechanism, so blocking these molecules may cause serious immune-related adverse events (IrAE), including fulminant insulin-dependent (type 1) diabetes. Here, we describe a patient with fulminant type 1 diabetes induced by nivolumab, an anti-PD-1 antibody. The patient, a 78-year-old man, was being treated with nivolumab as a third-line treatment for squamous cell carcinoma of the lung. After three cycles, he experienced an abrupt flare-up of the blood glucose within half a day. His blood glucose further increased without clinical symptoms until his hospital visit. Laboratory data showed the complete exhaustion of intrinsic insulin and the elevation of serum antibody titer to glutamic acid decarboxylase (GAD). Although the patient was previously diagnosed with non-insulin-dependent (type 2) diabetes, his disease activity had been well controlled with oral medication and low-dose insulin therapy until just before the flare-up. Because of the laboratory findings and the extremely rapid onset of hyperglycemia, a diagnosis of fulminant, rather than the rapid onset, type 1 diabetes related to nivolumab therapy was strongly suspected. Our case study indicates that fulminant hyperglycemia can occur extremely rapidly. The blood glucose of patients receiving PD-1 antibody therapy should be closely monitored.

https://ift.tt/2N77L4a

ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis

Publication date: Available online 11 July 2018

Source: Autoimmunity Reviews

Author(s): Xiwen Dong, Zhaohui Zheng, Yue Zhai, Yan Zheng, Jin Ding, Jianli Jiang, Ping Zhu

Abstract

The production of anti-citrullinated peptide antibodies (ACPAs) requires the participation of both innate immunity and adaptive immunity. On the one hand, activated innate immunity is able to produce citrullinated auto-antigens that fuel autoimmunity and provide an inflammatory environment that facilitates the breach of self-tolerance, proliferation of self-reactive T/B cells and the production of ACPAs. On the other hand, after their production by plasma B cells, ACPAs are also able to interact with innate immunity to exacerbate the manifestation and chronicity of rheumatoid arthritis (RA). This article discusses the roles of citrullinated peptides and ACPA played in innate immunity and autoimmunity. In addition, we emphasise the relationships between environmental factors and innate immunity, as well as the pathogenic function of ACPAs per se. In doing so, we hope to provide fundamental knowledge of RA pathogenesis and reveal potential therapeutic targets in RA treatment.

https://ift.tt/2mbadeE