Case 23-2018: A 36-Year-Old Man with Episodes of Confusion and Hypoglycemia

Presentation of Case. Ms. Sarah J. Grzybinski (Emergency Medicine): A 36-year-old man was admitted to this hospital because of episodes of altered mental status. The patient had been well until 6 years before admission, when his wife observed an episode of unusual behavior. During the episode, the…

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The continuing effect of the discovery of IgE by Kimishige Ishizaka

Publication date: Available online 1 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Thomas A.E. Platts-Mills

Sadly, Kimi Ishizaka died on July 6, 2018. I would like to take the opportunity to consider his role in the discovery of IgE and the effect of that discovery. All of us owe an enormous debt to those who established the relevance of IgE and the importance of its receptor on basophils and mast cells. In my own case, I owe a special debt for the pleasure and extraordinary education of working with him at Hopkins between September 1971 and October 1974.

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Cosmetics, Vol. 5, Pages 48: Cosmetic Formulation Based on an Açai Extract

Cosmetics, Vol. 5, Pages 48: Cosmetic Formulation Based on an Açai Extract

Cosmetics doi: 10.3390/cosmetics5030048

Authors: Roberta Censi Dolores Vargas Peregrina Giovanna Lacava Dimitrios Agas Giulio Lupidi Maria Giovanna Sabbieti Piera Di Martino

(1) Background: Açai berry extract is known for its high content in polyphenols and thus is a promising ingredient for cosmetic antiaging formulations; (2) Methods: In this study, the açai extract was firstly evaluated for its total phenol content (Folin Ciocalteau essay) and antioxidant activity (radical scavenging activity—DPPH; radical cation scavenging capacity—ABTS; ferric reducing antioxidant capacity—FRAP). Next, the açai extract was included in an O/W formulation and again was evaluated for its polyphenol content and antioxidant capacity. The formulation was tested for general characteristics, physicochemical properties and microbial stability. The proliferative effect on human immortalized fibroblasts was evaluated by the MTT essay, while TAC assay served to confirm that fibroblasts are protected from UV irradiation. The irritant potential was verified on 20 volunteers. The study concluded with the assessment of the sensorial characteristics of the cosmetic formulation; (3) Results: The pure açai extract exhibited high polyphenol content and antioxidant activity, and these characteristics were preserved in the O/W formulation as well. The O/W cosmetic formulation proved to be stable under accelerated and normal conditions, and the preservatives were successful in challenging the resistance against microbial contamination. The mean irritant potential was zero in all volunteers, and the cosmetic formulation showed a good sensorial profile; (4) Conclusions: Açai extract is an interesting ingredient for cosmetic antiaging formulations.

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RE: “DESIGN STRATEGY OF THE SABES STUDY: DIAGNOSIS AND TREATMENT OF EARLY HIV INFECTION AMONG MEN WHO HAVE SEX WITH MEN AND TRANSGENDER WOMEN IN LIMA, PERU, 2013–2017”

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Allergic Contact Dermatitis Evaluation: Strategies for the Preschooler

Abstract

Purpose of Review

The environment for the developing children is complex as they are exposed to a variety of activities and settings where potential environmental allergens may be encountered. Recent evidence supports the clinical benefit of patch testing young children suffering from recalcitrant dermatitis. While patch testing has been recently approved by the Food and Drug Administration in children ages 6–18 years old, patch testing strategies for young children of preschool age (between 2 and 6 years old) have yet to be defined.

Recent Findings

Allergic contact dermatitis is underdiagnosed among pediatric patients, particularly those suffering from concomitant atopic dermatitis as the interplay between the two diseases is complex. Recent reports in literature supported the clinical value, safety, and efficacy of patch testing pediatric patients.

Summary

This review provides an overview of specific pediatric allergens, special considerations, practical modifications, and systematic exposure-driven guidance approaches toward patch testing preschoolers.

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Periodontitis may modulate long-non coding RNA expression

Publication date: Available online 1 August 2018

Source: Archives of Oral Biology

Author(s): Fausto Sánchez-Muñoz, Gustavo Martínez-Coronilla, Ana Gabriela Leija-Montoya, Ulises Rieke-Campoy, Rosa Angelina Lopez-Carrasco, María de Lourdes Montaño-Pérez, Ernesto Beltrán-Partida, Yolanda Bojórquez-Anaya, Nicolas Serafin-Higuera, Javier González-Ramírez

Abstract

Periodontitis is a chronic inflammatory disease that compromises the integrity of the periodontium. Despite extensive research involving periodontitis, the detailed mechanisms underlying periodontal inflammation remain unclear. However, new important expression regulators have been emerging, such as non-coding RNAs, which are important determinants in the molecular control of the inflammatory process. Taking into consideration the vital role of non-coding RNAs, we determined for the first time the expression profiles of different long non-coding RNAs (lncRNAs) that are implicated in inflammation. In this study, we take periodontal samples of healthy subjects, patients with gingivitis and with periodontitis. In both disease groups, the lncRNA OIP5-AS1 expression levels were lower than levels in healthy subjects (P < 0.05). This study reveals new insights into the relative levels of OIP5-AS1 lncRNA in healthy, gingivitis and periodontal tissue, which may have important applications as a potential biomarker with protagonist activity in the development and manifestation of destructive periodontitis.

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Long-Term Therapy with Corticosteroids in Nasal Polyposis: A Bone Metabolism Assessment

Abstract

Chronic rhinosinusitis associated with nasal polyposis (RSCwNP) affects 4% of the general population. As chronic condition, it requires chronic pharmacological treatment, whereas the surgical approach becomes necessary in obstructive and/or complicated cases. Intranasal and systemic corticosteroids (CS) represent the "Gold Standard" treatment for RSCwNP. The present study aimed to evaluate the side effects of prednisone in a group of patients with RSCwNP treated with long-term CS. In particular, attention was focused on bone disorders (osteopenia and osteoporosis) and prospective fracture risk increase. Forty patients (26 females, mean age 55.70 ± 14.03 years) affected by RSCwNP have been enrolled. Control group included 40 healthy subjects (17 females, mean age 56.37 ± 13.03 years). Nasal endoscopy, skin prick tests, nasal cytology, and bone densitometry were evaluated in all subjects. The likelihood of impaired bone metabolism (osteopenia or osteoporosis) was superimposable in both groups. Within RSCwNP group, no parameter was statistically significant in predicting a metabolism alteration.

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