Combined Unilateral Posteroventral Pallidotomy and Ventral Intermediate Nucleus Thalamotomy in Tremor-Dominant Parkinson's Disease versus Posteroventral Pallidotomy Alone: A Prospective Comparative Study

Background: The optimum target in surgery for Parkinson's disease (PD) is still controversial, especially in patients with tremor-dominant PD. We aim to compare results in tremor-dominant patients undergoing pallidotomy vs. those undergoing simultaneous posteroventral pallidotomy (PVP) and ventral intermediate nucleus (VIM) thalamotomy. Methods: Twenty-four patients with tremor-dominant PD were included in this study. Twelve patients received unilateral PVP contralateral to the most affected side. The other 12 patients received simultaneous unilateral PVP and VIM thalamotomy contralateral to the most affected side. Assessment of results in both groups was achieved using both UPDRS "off" motor scores and UPDRS rest tremor subscores. Results: The mean UPDRS off motor score improved in the pallidotomy group from 61.3 preoperatively to 36.8 at 12 months. In the combined group, it improved from 59.6 to 35.2 at 12 months, with no statistically significant difference between both groups. On the other hand, while the mean tremor subscore in the pallidotomy group improved from a mean of 2.3–0.8, the tremors were abolished in all of the patients in the combined group except for 1 patient who showed slight infrequent tremors at 12 months. Conclusion: Patients with tremor-dominant PD achieve more improvement in tremor control after combined PVP and VIM thalamotomy.
Stereotact Funct Neurosurg 2018;96:1–6

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Effects and parameters of the photobiomodulation in experimental models of third-degree burn: systematic review

Abstract

This systematic review was performed to identify the role of photobiomodulation therapy in experimental models of third-degree burns used to induce oxidative stress. EMBASE, PubMed, and CINAHL databases were searched for studies published between January 2003 and January 2018 on the topics of photobiomodulation therapy and third-degree burns. Any study that assessed the effects of photobiomodulation therapy in animal models of third-degree burns was included in the analysis. A total of 17 studies were selected from 1182 original articles targeted on photobiomodulation therapy and third-degree burns. Two independent raters with a structured tool for rating the research quality critically assessed the articles. Although the small number of studies limits the conclusions, the current literature research indicates that photobiomodulation therapy can be an effective short-term approach to accelerate the healing process of third-degree burns, to increase and modulate the inflammatory process, to accelerate the proliferation of fibroblasts, and to enhance the quality of the collagen network. However, differences still exist in the terminology used to describe the parameters and the dose of photobiomodulation therapy.

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Status of Superficial Esophageal Cancers Treated by Endoscopy "OESOFARE"

Condition:   Superficial Esophageal Cancers
Intervention:  
Sponsor:   Nantes University Hospital
Not yet recruiting

https://ift.tt/2PKx1yw

Assessing Timing of Enteral Feeding Support in Esophageal Cancer Patients on Muscle functTion and Survival

Conditions:   Esophageal Cancer;   Nutrition Aspect of Cancer;   Postoperative Complications;   Muscle Weakness;   Sarcopenia;   Jejunostomy; Complications
Intervention:   Other: delayed start enteral support @ POD5
Sponsor:   University Hospital, Gasthuisberg
Not yet recruiting

https://ift.tt/2xju7Kr

HRQOL in Thyroid Cancer and Thyroid Tumours

Conditions:   Thyroid Nodule;   Thyroid Cancer;   Quality of Life
Intervention:  
Sponsor:   Oslo University Hospital
Recruiting

https://ift.tt/2PLTZ8j

Status of Superficial Esophageal Cancers Treated by Endoscopy "OESOFARE"

Condition:   Superficial Esophageal Cancers
Intervention:  
Sponsor:   Nantes University Hospital
Not yet recruiting

https://ift.tt/2PKx1yw

Assessing Timing of Enteral Feeding Support in Esophageal Cancer Patients on Muscle functTion and Survival

Conditions:   Esophageal Cancer;   Nutrition Aspect of Cancer;   Postoperative Complications;   Muscle Weakness;   Sarcopenia;   Jejunostomy; Complications
Intervention:   Other: delayed start enteral support @ POD5
Sponsor:   University Hospital, Gasthuisberg
Not yet recruiting

https://ift.tt/2xju7Kr