Mixed Reality With Hololens® Exercise Protocol

Condition:   Healthy Volunteers
Interventions:   Other: Mixed reality;   Other: Conventional exercise group
Sponsor:   Centro Universitario La Salle
Not yet recruiting

https://ift.tt/2NCe4MX

Post-radiation Dental Disease Amongst Head and Neck Cancer Patients

Conditions:   Head and Neck Cancer;   Caries, Dental;   Periodontal Diseases;   Radiotherapy Side Effect
Intervention:   Radiation: Radiotherapy (curative) for head and neck cancer
Sponsors:   Belfast Health and Social Care Trust;   Queen's University, Belfast
Not yet recruiting

https://ift.tt/2OSrZDk

Mixed Reality With Hololens® Exercise Protocol

Condition:   Healthy Volunteers
Interventions:   Other: Mixed reality;   Other: Conventional exercise group
Sponsor:   Centro Universitario La Salle
Not yet recruiting

https://ift.tt/2NCe4MX

Post-radiation Dental Disease Amongst Head and Neck Cancer Patients

Conditions:   Head and Neck Cancer;   Caries, Dental;   Periodontal Diseases;   Radiotherapy Side Effect
Intervention:   Radiation: Radiotherapy (curative) for head and neck cancer
Sponsors:   Belfast Health and Social Care Trust;   Queen's University, Belfast
Not yet recruiting

https://ift.tt/2OSrZDk

Drilling and control of the internal auditory canal by fixed endoscope

Publication date: Available online 11 October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): X. Dubernard, J.-C. Kleiber, M. Makeieff, A. Bazin, A. Chays

Abstract

Preservation of vestibular structures, particularly the posterior semicircular canal, is essential to ensure hearing preservation in addition to complete tumour resection during retrosigmoid surgical resection of a vestibular schwannoma. Drilling of the internal auditory canal (IAC) is a delicate step, during which these structures can be accidentally perforated. The orientation of the IAC results in the formation of poorly visible zones that can predispose to perforation of these structures when drilling is performed with a microscope. Hand-held endoscopy exposes all of the operative field, but immobilizes one of the surgeon's hands, making this surgery even more delicate. Fixed endoscopy is a solution that gives the surgeon greater freedom of movement, while ensuring precise control of the surgical procedure. It allows identification and avoidance of vestibular structures, while allowing resection as close as possible to the tumour. The schwannoma can be entirely cleaved when the fundus of the IAC is correctly controlled, while sparing the facial and cochlear nerves.

https://ift.tt/2PwjZF0

French Society of Otorhinolaryngology and Head and Neck Surgery (SFORL) guidelines concerning the role of otorhinolaryngologists in the management of paediatric obstructive sleep apnoea syndrome: Follow-up protocol for treated children

Publication date: Available online 11 October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): M. Akkari, R. Marianowski, F. Chalumeau, P. Fayoux, N. Leboulanger, P.J. Monteyrol, M. Mondain, Groupe de Travail de la SFORL

Abstract

Objectives

The authors present the French Society of Oto-Rhino-Laryngology and Head and Neck Surgery (SFORL) clinical practice guidelines concerning the role of otorhinolaryngologists in the management of paediatric obstructive sleep apnoea syndrome (OSAS). This chapter is devoted to the follow-up protocol for children treated for OSAS.

Methods

A multidisciplinary task force was commissioned to carry out a review of the scientific literature on this topic. On the basis of the articles selected and the personal experience of each member of the task force, guidelines were drafted and graded as A, B or C or expert opinion according to a decreasing level of scientific evidence, and were then reviewed by a reading committee, independently of the task force. The final guidelines were established at a consensus meeting.

Results

Short-term, medium-term and long-term clinical follow-up and complementary investigations are necessary in view of the risk of residual OSAS, and the risk of recurrence of OSAS related to adenoid and tonsillar regrowth following adenotonsillectomy, the treatment most commonly performed. The modalities of follow-up after surgery, continuous positive airway pressure (CPAP) ventilation, orthodontic treatment, myofascial rehabilitation, and drug therapy are described. The indications for nasal endoscopy and sleep studies as part of follow-up are specified.

https://ift.tt/2yeptxE

Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade

Abstract

Myeloid-derived suppressor cells (MDSCs) are immature monocytes and granulocytes that impede immune-mediated clearance of malignant cells by multiple mechanisms, including the formation of immunosuppressive reactive oxygen species (ROS) via the myeloid cell NADPH oxidase (NOX2). Histamine dihydrochloride (HDC), a NOX2 inhibitor, exerts anti-cancer efficacy in experimental tumor models but the detailed mechanisms are insufficiently understood. To determine effects of HDC on the MDSC compartment we utilized three murine cancer models known to entail accumulation of MDSC, i.e. EL-4 lymphoma, MC-38 colorectal carcinoma, and 4T1 mammary carcinoma. In vivo treatment with HDC delayed EL-4 and 4T1 tumor growth and reduced the ROS formation by intratumoral MDSCs. HDC treatment of EL-4 bearing mice also reduced the accumulation of intratumoral MDSCs and reduced MDSC-induced suppression of T cells ex vivo. Experiments using GR1-depleted and Nox2 knock out mice supported that the anti-tumor efficacy of HDC required presence of NOX2⁺ GR1⁺ cells in vivo. In addition, treatment with HDC enhanced the anti-tumor efficacy of programmed cell death receptor 1 (PD-1) and PD-1 ligand checkpoint blockade in EL-4- and MC-38-bearing mice. Immunomodulatory effects of a HDC-containing regimen on MDSCs were further analyzed in a phase IV trial (Re:Mission Trial, ClinicalTrials.gov; NCT01347996) where patients with acute myeloid leukemia received HDC in conjunction with low-dose IL-2 (HDC/IL-2) for relapse prevention. Peripheral CD14⁺HLA-DR^−/low MDSCs (M-MDSCs) were reduced during cycles of HDC/IL-2 therapy and a pronounced reduction of M-MDSCs during HDC/IL-2 treatment heralded favorable clinical outcome. We propose that anti-tumor properties of HDC may comprise the targeting of MDSCs.

https://ift.tt/2OZm9QM