Oral peanut immunotherapy ‐ How much is too much? How much is enough?

Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2CAcRUH

Delayed granulomatous reaction and cutaneous fistula induced by retained electrodes from a cardiac pacemaker in a child

Pediatric Dermatology, EarlyView.


https://ift.tt/2PdLRkw

Cover Image

Head &Neck, Volume 40, Issue 10, Page C1-C1, October 2018.


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Issue Information

Head &Neck, Volume 40, Issue 10, Page 2117-2120, October 2018.


https://ift.tt/2AnNjIQ

Issue Information

Journal of Neuroendocrinology, Volume 30, Issue 11, November 2018.


https://ift.tt/2Sen0Mf

Autophagy and its potent modulators from phytochemicals in cancer treatment

Abstract

Autophagy is a ubiquitous catabolic process by which damaged or harmful intracellular components are delivered to the lysosomes for self-digestion and recycling. It is critical in cancer treatment. Therapy-induced autophagy predominantly acts as a pro-survival mechanism, but progressive autophagy can lead to non-apoptotic cell death, also known as autophagic cell death. Plants or herbs contain various natural compounds that are widely used in the treatment of many types of malignancies. Emerging evidence indicates that phytochemicals targeting the autophagic pathway are promising agents for cancer treatment. However, these compounds play different roles in autophagy. In this review, we discussed the role of autophagy in cancer development and therapy, and focussed on elucidating the anti-cancer activities of autophagic modulators, especially phytochemicals. Notably, we described a novel premise that the dynamic role of phytochemicals should be evaluated in regulation of autophagy in cancer.

https://ift.tt/2AnlK2s

Network meta‐analyses of systemic treatments for psoriasis: a critical appraisal

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2An72Zc