Successful treatment of metastatic extramammary Paget's disease with pemetrexed monotherapy systemically and 5-fluorouracil topically

Kexu Chen, Hanlin Liang, Jiewen Peng, Yanfang Zheng

Indian Journal of Dermatology, Venereology, and Leprology 2019 85(1):56-59

Advanced extramammary Paget's disease does not have a standardized treatment guideline as its incidence is low and has been rarely reported in literature. Here we describe a case of metastatic extramammary Paget's disease successfully treated with topical 5-fluorouracil (5-FU) and systemic pemetrexed. The therapy was safe without any appreciable adverse effects like diarrhea, rash, neutropenia or fatigue; maintaining remission for more than 6 months. Thus, we propose 5-FU and pemetrexed as the first-line therapy for advanced extramammary Paget's disease, especially for aged patients with unresectable skin lesions.

http://bit.ly/2VlYZUV

Everything is in the name: Macular hyperpigmentation of uncertain etiology or acquired dermal macular hyperpigmentation of varied etiologies?

Anuradha Bishnoi, Keshavamurthy Vinay, Sendhil Muthu Kumaran, Davinder Parsad

Indian Journal of Dermatology, Venereology, and Leprology 2019 85(1):85-87



http://bit.ly/2QbCdvf

“Hereditary Angioedema and Inducible Urticaria: Not Mutually Exclusive.”

A 33-year-old Hispanic woman presented to the allergy and immunology clinic for recurrent angioedema. She was previously healthy until she began to experience intermittent, infrequent episodes of angioedema at age 25. Prior to evaluation, she had experienced seven episodes of angioedema affecting the extremities with no oropharyngeal or abdominal involvement. The angioedema was non-pruritic and was not associated with urticaria, trauma, foods, medication, infections, or menstruation. She did not take any medications, including angiotensin-converting enzyme inhibitors or hormonal therapies.

http://bit.ly/2GLSXcZ

Collodion baby treated at a tertiary hospital in Tanzania: a case report

The term "collodion baby" is used to describe a newborn covered with a translucent, parchment-like skin sheet. It is an extremely rare condition with an estimated incidence of 1 in 300,000 live births. Clinica...

http://bit.ly/2SuXj9M

Lung cancer masquerading as fungus-associated mucoid impaction

http://bit.ly/2SstZAM

Correction: Acute subretinal abscess in Staphylococcus aureus septicaemia with endophthalmitis showcased by multimodal retinal imaging and with 2-year follow-up

http://bit.ly/2Ai9KyH

Rheumatoid meningitis: successful remission with rituximab

A 53-year-old male with rheumatoid arthritis presented with recurrent headaches, seizures and right-sided lower extremity paralysis while on antiepileptic medications. Work up revealed pachymeningeal and leptomeningeal enhancement on brain MRI. Differential diagnosis included a variety of infections, neoplasm and vasculitis. Histopathology showed findings consistent with rheumatoid meningitis (RM). Ultimately based on symptoms, MRI findings and tissue pathology, he was diagnosed with RM. Intravenous pulse dose steroids were initiated followed by rituximab every 6 months, resulting in significant improvement of the brain MRI findings. Patient has remained seizure free.

http://bit.ly/2Sz5ZMw