Oxidative stress in prelingual sensorineural hearing loss and the effects of cochlear implant application on serum oxidative stress levels

Publication date: Available online 31 January 2019

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Mustafa Celik, İsmail Koyuncu

Abstract

Objectives

The aim of this study is to investigate oxidative stress conditions in patients with prelingual profound sensorineural hearing loss (SNHL) and the effects of cochlear implant application on oxidative stress. In addition, we also aimed to evaluate the correlation between pre- and post-surgery oxidative stress markers and Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS), Meaningful Use of Speech Scale (MUSS) and Free-Field Audiometry (FFA).

Methods

This is a prospective controlled study of the Ear-Nose-Throat Department of the Harran University Faculty of Medicine between April 2017 and January 2018. The study included 25 patients with prelingual profound SNHL diagnosis and cochlear implant surgery and 25 healthy control groups. Total thiol, native thiol, disulphide levels and LOOH levels were studied in serum samples taken from the patient group 2 weeks before and 6 months after the cochlear implant surgery and the healthy control group. In addition, IT-MAIS, MUSS and FFA tests, which were used to evaluate the personal development of patients with cochlear implants, were performed at preoperative and postoperative 6th month.

Results

In our study, we found that the levels of native thiol (p<0.01) and total thiol (p <0.01) were significantly lower and LOOH (p<0.04) values were significantly higher in preoperative SNHL patients than control group. We found that native thiol, total thiol values increased and LOOH values decreased in the postoperative with respect to preoperative values. However, the difference between preoperative and post operative values was not statistically significant. The correlation between pre- and post-surgery biochemical data and IT-MAIS, MUSS and FFA tests were found not to be significant.

Conclusions

Our study suggests that patients with prelingual profound SNHL are under oxidative stress and post-CI surgery data show that there is no significant relief in patients. This study can shed light on the biologic mechanisms between prelingual profound SNHL and oxidative stress.

http://bit.ly/2SlLYMe

Stridor as initial presentation of Rolandic Epilepsy

Publication date: Available online 30 January 2019

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): José Ferreira Penêda, Sandra Alves, Francisco Monteiro, Inês Sousa Ribeiro, Nuno Barros Lima, Artur Condé

Abstract

The authors present the case of a 5-year-old girl referred to our institution due to several episodes of nocturnal stridor with ocular retroversion and parental notion of apnea. She has been previously submitted to adenotonsillectomy. Due to symptoms worsening she was referred to our hospital. Here, a nasal fiberoptic endoscopy evaluation was conducted and a diagnosis of laryngomalacia was done. The was submitted to CO2 laser ariepiglotoplasty with symptom improvement after surgery. During a follow-up appointment, parents reported self-limited clonic facial movements at sleep onset. The electroencephalogram (EEG) was compatible with benign childhood epileptiform discharges.

http://bit.ly/2HGnB7X

Pediatric Acute Unilateral Suppurative Lymphadenitis: The Role of Antibiotic Susceptibilities at a Large Tertiary Pediatric Care Center

Publication date: Available online 30 January 2019

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Nathan R. Lindquist, Ankita Patro, Sarah A. Gitomer, Karina T. Cañadas

http://bit.ly/2SiQtav

Thanks to reviewers

Publication date: February 2019

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 136, Issue 1

Author(s):

http://bit.ly/2sVIkdE

Contents

Publication date: February 2019

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 136, Issue 1

Author(s):

http://bit.ly/2MFMu2F

Serum-based metabolomics characterization of patients with reticular oral lichen planus

Publication date: Available online 30 January 2019

Source: Archives of Oral Biology

Author(s): Xu-zhao Li, Shuai-nan Zhang, Xu-yan Yang

Abstract

Objective

Oral lichen planus (OLP) is a chronic inflammatory mucosal lesion and systemic disease. In OLP, reticular type is the most common presentation of the disease. However, little is known about it. The aim of this study was to analyze the pathogenesis of reticular OLP and its possible associations with the pathological changes in other organ systems through serum-based metabolomics.

Methods

Blood samples were obtained from 16 reticular OLP patients and 24 control subjects. Liquid chromatography (LC)-mass spectrometry (MS) system was used to identify differentially expressed metabolites. The pathways analysis was performed by MetaboAnalyst. Pathological network was constructed by Cytoscape software.

Results

Totally, 31 modulated metabolites were identified, whose dysregulations affected 25 metabolic pathways and 7 pathological processes in the disease. Through an impact-value screen (impact-value＞0.1), 6 pathways were selected as the significantly dysregulated pathways. Pathological network showed that these metabolites participated in 7 pathological processes, that is, apoptosis process, DNA damage and repair disorder, oxidative stress injury, carbohydrate metabolism disorder, mood dysfunction, inflammatory lesion, and other pathological process.

Conclusion

The study demonstrated that reticular OLP could cause the dysregulations of the metabolites in serum, which might be also further linked to other organ and systemic diseases through the blood system, such as diabetes, sleep disorders, and depression, etc.

http://bit.ly/2sSVVCK

Influence of low-level laser therapy on orthodontically-induced inflammatory root resorption. A systematic review

Publication date: Available online 30 January 2019

Source: Archives of Oral Biology

Author(s): Dimitrios Michelogiannakis, Deema Al-Shammery, Zohaib Akram, P. Emile Rossouw, Fawad Javed, Georgios E. Romanos

Abstract

Objective

The aim was to assess the influence of low-level laser therapy (LLLT) on orthodontically-induced inflammatory root resorption (OIIRR).

Methods

A systematic search was conducted in indexed databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The eligibility criteria were as follows: (a) original clinical and animal/experimental studies; (b) prospective studies; (c) intervention: effect of LLLT on OIIRR; (d) control group (OIIRR without LLLT); (e) statistical analysis; and (f) tomographic or histologic assessment of OIIRR. Quality assessment of the experimental and clinical studies was performed following the Animal Research Reporting In-vivo Experiments (ARRIVE) and Consolidated Standards of Reporting Trials (CONSORT) guidelines, respectively. The risk of bias of the included studies was also determined.

Results

Nine (7 experimental and 2 clinical) of the initially identified 39 studies were included. One clinical and 2 experimental studies showed that LLLT during orthodontic tooth movement (OTM) significantly reduces OIIRR. One experimental study reported that LLLT during OTM in sockets treated with alloplastic materials significantly reduces OIIRR. One experimental study found that LLLT after OTM significantly repairs OIIRR, whereas one clinical study did not report a significant reparative affect. Three experimental studies showed that LLLT increases OIIRR during OTM, corticotomized-OTM, and OTM into grafted defects, respectively. The minimum, median and highest ARRIVE scores (out of 20) of the included experimental studies were 15, 17 and 19, respectively. The mean CONSORT score of the included clinical studies was 23 (out of 25).

Conclusions

In conclusion, the influence of LLLT on OIIRR remains debatable.

http://bit.ly/2MFNXFW