Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

Αρχειοθήκη ιστολογίου

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Η λίστα ιστολογίων μου

Κυριακή 2 Ιουνίου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


Nutrients to Protect Your Skin From Summer Sun Mercola Natural Health Articles - 1h ago Preview  ...
Nutrients to Protect Your Skin From Summer SunMercola Natural Health Articles - 1h ago Preview    AUTO POST  SAVE TO EVERNOTESummer and sunshine-filled days are upon us and, with that, increased calls for the use of sunscreen. Unfortunately, most sunscreens contain toxic ingredients that are easily absorbed through your skin and can jeopardize your health.The good news is you can support healthy skin and protect it from ultraviolet damage from the inside. Scientists have identified several nutrients...
Αλέξανδρος Γ. Σφακιανάκης
2m
Do Hair, Skin and Nail Supplements Work? Mercola Natural Health Articles - 1h ago Preview     AUTO...
Do Hair, Skin and Nail Supplements Work?Mercola Natural Health Articles - 1h ago Preview    AUTO POST  SAVE TO EVERNOTEStrong, shiny hair and fingernails (and toenails) that are smooth and uniform in color, and soft, glowing skin are typically viewed as some of the more visible signs of health. Most children have all of the above, but often with factors like stress hormones, oxidative stress and a less-than-healthy diet, your hair and nails can become dry and brittle, and your skin rough and blemished.If...
Αλέξανδρος Γ. Σφακιανάκης
3m
Bacteria, Agriculture and Cupping Mercola Natural Health Articles - 1h ago Preview     AUTO POST ...
Bacteria, Agriculture and CuppingMercola Natural Health Articles - 1h ago Preview    AUTO POST  SAVE TO EVERNOTE1 Research suggests the following herbicide and desiccant, when combined with lectin-rich foods such as peas, beans or potatoes, can trigger the neurological damage seen in patients with Parkinson's disease:GlyphosateDiquatDicambaParaquatResearch shows the desiccant paraquat can trigger Parkinson's disease when combined with plant lectins found in peas, beans, potatoes and many other foods,...
Αλέξανδρος Γ. Σφακιανάκης
4m
Fasting Prevents and Halts Diabetes Mercola Natural Health Articles - 1h ago Preview     AUTO POST ...
Fasting Prevents and Halts DiabetesMercola Natural Health Articles - 1h ago Preview    AUTO POST  SAVE TO EVERNOTEFasting has been practiced for centuries. In fact, science shows that, like animals, we have a fasting instinct that extends through the ages: Hippocrates prescribed and championed fasting while using apple cider vinegar.1Religions around the world developed fasting independently as a practice and the Greeks not only prescribed it for illness, but required it in preparation for many rituals...
Αλέξανδρος Γ. Σφακιανάκης
5m
The Benefits of Vacations for Your Mental Health What is psychology? by Wip - 1h ago Preview    ...
The Benefits of Vacations for Your Mental HealthWhat is psychology? by Wip - 1h ago Preview    AUTO POST  SAVE TO EVERNOTEHave you gone on a trip recently? If you've been doing nothing but work work work, then chances are, a vacation is something that can help you.  While getting therapy from different outlets, including Regain.us, is beneficial, sometimes taking a break and going on vacation can really help you feel better and kickstart your mental health once again. How? Well, read on to find out!Reduces...
Αλέξανδρος Γ. Σφακιανάκης
6m
Targeting Neuropathic Pain: Pathobiology, Current Treatment and Peptidomimetics as a New Therapeutic...
Targeting Neuropathic Pain: Pathobiology, Current Treatment and Peptidomimetics as a New Therapeutic Opportunity.pubmed curr med chem [jour..... - 1h ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesTargeting Neuropathic Pain: Pathobiology, Current Treatment and Peptidomimetics as a New Therapeutic Opportunity.Curr Med Chem. 2019 May 30;:Authors: Brizzi A, Caroleo MC, De Rosa M, Pandey A, Gallelli L, Badolato M, Carullo G, Cione EAbstractThere is a huge need for pharmaceutical agents for...
Αλέξανδρος Γ. Σφακιανάκης
6m
Radiochemistry; A useful tool in the ophthalmic drug discovery. pubmed curr med chem [jour..... -...
Radiochemistry; A useful tool in the ophthalmic drug discovery.pubmed curr med chem [jour..... - 1h ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesRadiochemistry; A useful tool in the ophthalmic drug discovery.Curr Med Chem. 2019 May 30;:Authors: Pulagam KR, Gómez-Vallejo V, Llop J, Rejc LAbstractPositron Emission Tomography (PET) and Single Photon Emission Computerized Tomography (SPECT) are ultra-sensitive, fully translational and minimally invasive nuclear imaging techniques capable...
Αλέξανδρος Γ. Σφακιανάκης
7m
Profile of trauma mortality and trauma care resources at rural emergency departments and urban trauma...
Profile of trauma mortality and trauma care resources at rural emergency departments and urban trauma centres in Quebec: a population-based, retrospective cohort studyBMJ Open Current Issue by Fleet, R., Lauzier, F., Tounkara, F.. - 32m ago Preview    AUTO POST  SAVE TO EVERNOTEObjectivesAs Canada's second largest province, the geography of Quebec poses unique challenges for trauma management. Our primary objective was to compare mortality rates between trauma patients treated at rural emergency...
Αλέξανδρος Γ. Σφακιανάκης
8m
Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration...
Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy [Research]Canadian Medical Association Journal - J.. by Sultan, A. A., Muller, S., Whittle,.. - 29m ago Preview    AUTO POST  SAVE TO EVERNOTEBACKGROUND:Systemic inflammatory diseases have been associated with increased risk of venous thromboembolism. We aimed to quantify the risk of venous thromboembolism in patients with gout, the most common inflammatory arthritis, and...
Αλέξανδρος Γ. Σφακιανάκης
10m
Características clínico-epidemiológicas del carcinoma de células de Merkel en una serie de 38 pacientes...
Características clínico-epidemiológicas del carcinoma de células de Merkel en una serie de 38 pacientesScienceDirect Publication: Actas Dermo-S.. - 28m ago Preview    AUTO POST  SAVE TO EVERNOTEPublication date: June 2019Source: Actas Dermo-Sifiliográficas, Volume 110, Issue 5Author(s): M. Dañino-García, J.J. Domínguez-Cruz, C. Pérez-Ruiz, J. Conejo-Mir, J.J. Pereyra-RodríguezResumenIntroducciónEl carcinoma de células de Merkel (CCM) es un tumor cutáneo muy agresivo y de mal pronóstico, aunque la...
Αλέξανδρος Γ. Σφακιανάκης
11m
Características epidemiológicas de la psoriasis. Un estudio poblacional ScienceDirect Publication:...
Características epidemiológicas de la psoriasis. Un estudio poblacionalScienceDirect Publication: Actas Dermo-S.. - 28m ago Preview    AUTO POST  SAVE TO EVERNOTEPublication date: June 2019Source: Actas Dermo-Sifiliográficas, Volume 110, Issue 5Author(s): J.M. Fernández-Armenteros, X. Gómez-Arbonés, M. Buti-Solé, A. Betriu-Bars, V. Sanmartin-Novell, M. Ortega-Bravo, M. Martínez-Alonso, J.M. Casanova-SeumaResumenAntecedentes y objetivoLa psoriasis es una enfermedad inmunoinflamatoria crónica de la...
Αλέξανδρος Γ. Σφακιανάκης
13m
Presentación atípica de infección por virus de herpes simple tipo ii (VHS II) refractaria a tratamiento...
Presentación atípica de infección por virus de herpes simple tipo ii (VHS II) refractaria a tratamiento con aciclovir en 2 pacientes hematológicosScienceDirect Publication: Actas Dermo-S.. - 26m ago Preview    AUTO POST  SAVE TO EVERNOTEPublication date: June 2019Source: Actas Dermo-Sifiliográficas, Volume 110, Issue 5Author(s): D. Nieto Rodríguez, E. Sendagorta Cudós, J.M. Rueda Carnero, P. Herranz PintoResumenLas infecciones por virus herpes presentan una frecuencia no desdeñable en pacientes hematológicos....
Αλέξανδρος Γ. Σφακιανάκης
13m
A four-year-old female was admitted for failure to thrive following recent sinusitis. Physical examination was positive for right sided facial pain, photophobia and right abducens nerve palsy
Gradenigo's syndrome in a four-year-old patient: a rare diagnosis in the modern antibiotic era.pubmed j laryngol otol [jo..... - 26m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesGradenigo's syndrome in a four-year-old patient: a rare diagnosis in the modern antibiotic era.J Laryngol Otol. 2019 May 28;:1-3Authors: Rossi N, Swonke ML, Reichert L, Young DAbstractOBJECTIVE: This study gives details of a rare case of petrous apicitis that presented as Gradenigo's syndrome and was managed...
Αλέξανδρος Γ. Σφακιανάκης
15m
A new technique of revision septoplasty using semi-penetrating straight and circular incisions of...
A new technique of revision septoplasty using semi-penetrating straight and circular incisions of the nasal septum.pubmed j laryngol otol [jo..... - 25m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesA new technique of revision septoplasty using semi-penetrating straight and circular incisions of the nasal septum.J Laryngol Otol. 2019 May 30;:1-7Authors: Wei L, Wang L, Lu W, Jiang T, Liu Z, Wang M, Wu X, Wang ZAbstractOBJECTIVE: This study aimed to investigate endoscopic revision septoplasty...
Αλέξανδρος Γ. Σφακιανάκης
16m
Role of Obesity in Otorhinolaryngologic Diseases Latest Results for Current Allergy and A.. - 25m...
Role of Obesity in Otorhinolaryngologic DiseasesLatest Results for Current Allergy and A.. - 25m ago Preview    AUTO POST  SAVE TO EVERNOTEAbstract Purpose of ReviewObesity is a major public health problem associated with various diseases. Improving obesity control and achieving greater patient satisfaction are critical unmet needs. Various otorhinolaryngologic diseases can have negative effects on quality of life or actual health status depending on their type. Over the past decade, the relationship...
Αλέξανδρος Γ. Σφακιανάκης
17m
Vitamin D and Otitis Media Latest Results for Current Allergy and A.. - 25m ago Preview     AUTO...
Vitamin D and Otitis MediaLatest Results for Current Allergy and A.. - 25m ago Preview    AUTO POST  SAVE TO EVERNOTEAbstract Purpose of ReviewTo examine the relationship between vitamin D and otitis media.Recent FindingsVitamin D deficiency has been associated with several respiratory diseases, including otitis media. Vitamin D supplementation may reduce the risk of otitis media. This relationship may be explained by vitamin D supporting the immune system by upregulating antimicrobial peptides which...
Αλέξανδρος Γ. Σφακιανάκης
17m
Xolair (Omalizumab) Significantly Reduced Nasal Polyps and Congestion Symptoms in Adults with Chronic...
Xolair (Omalizumab) Significantly Reduced Nasal Polyps and Congestion Symptoms in Adults with Chronic Rhinosinusitis with Nasal Polyps in Two Phase III StudiesBusiness Wire Health: Clinical Trials Ne.. - 14m ago Preview    AUTO POST  SAVE TO EVERNOTESOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced positive topline data from two Phase III multicenter studies evaluating Xolair® (omalizumab) for the treatment of adults...
Αλέξανδρος Γ. Σφακιανάκης
17m
Οι κρίσεις «πανικού» Ψυχο-γραφήματα by Ρεβέκκα Τσοχαντάρη - 10m ago Preview     AUTO POST  SAVE TO...
Οι κρίσεις «πανικού»Ψυχο-γραφήματα by Ρεβέκκα Τσοχαντάρη - 10m ago Preview    AUTO POST  SAVE TO EVERNOTEΑπό το Γιώργο Πιντέρη, ψυχολόγο, διδάκτορα Συμβουλευτικής Ψυχολογίαςwww.pinteris.grΜερικοί άνθρωποι παραπονιούνται ότι χωρίς καμία φανερή αιτία, τους πιάνει στα καλά καθούμενα μια κρίση που την ονομάζουν «κρίση πανικού». Η κρίση αυτή περιέχει κάποια ή  όλα από τα παρακάτω στοιχεία:Δύσπνοια (σαν ο αέρας να μην αρκετός)ΤαχυπαλμίαΕφίδρωσηΕπιθυμία φυγής (να το βάλεις στα πόδια)Ελαφρά σκοτοδίνηΣύντομη...
Αλέξανδρος Γ. Σφακιανάκης
18m
Does access to saltwater swimming pools reduce ear pathology and hearing loss in school children of...
Does access to saltwater swimming pools reduce ear pathology and hearing loss in school children of remote arid zone aboriginal communities? A prospective 3‐year cohort studyLinnett Sanchez  Andrew Simon Carney  Adrian Esterman  Karen Sparrow  David TurnerFirst published: 16 May 2019 https://doi.org/10.1111/coa.13364Read the full textePDFPDFTOOLS SHAREAbstractObjectiveTo assess whether access to saltwater chlorinated swimming pools in remote Aboriginal communities is beneficial in reducing levels...
Αλέξανδρος Γ. Σφακιανάκης
22m
Usefulness of ENT clinical examinations in hospitalised patients chronically addicted to alcohol and...
Usefulness of ENT clinical examinations in hospitalised patients chronically addicted to alcohol and tobacco to detect head and neck squamous cell carcinomas. A retrospective study of 159 patientsMaxime Baert  Caroline Pascual  Aurélie Biet‐Hornstein  Ritoungarte Nadjingar  Céline Haremza  Cyril PageFirst published: 02 May 2019 https://doi.org/10.1111/coa.13355Read the full textePDFPDFTOOLS SHAREAbstractObjectiveTo determine whether an ENT clinical screening examination done on all patients chronically...
Αλέξανδρος Γ. Σφακιανάκης
22m
Long term evaluation of sound localization in single sided deaf adults fitted with a BAHA device Nicolas‐Xavier...
Long term evaluation of sound localization in single sided deaf adults fitted with a BAHA deviceNicolas‐Xavier Bonne  Jean‐Noël Hanson  Fanny Gauvrit  Michaël Risoud  Christophe VincentFirst published: 28 May 2019 https://doi.org/10.1111/coa.13381This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please...
Αλέξανδρος Γ. Σφακιανάκης
23m
Optimal Wound Closure Techniques for Thyroid and Parathyroid Surgery: A Systematic Review of Cosmetic...
Optimal Wound Closure Techniques for Thyroid and Parathyroid Surgery: A Systematic Review of Cosmetic OutcomesKristina Lee  Nicholas Ward  Babatunde Oremule  Navin ManiFirst published: 30 May 2019 https://doi.org/10.1111/coa.13382This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article...
Αλέξανδρος Γ. Σφακιανάκης
23m
Increased Maternal Serum Placental Growth Hormone Variant in Pregnancies Complicated by Otosclerosis...
Increased Maternal Serum Placental Growth Hormone Variant in Pregnancies Complicated by OtosclerosisShutan Liao  Shan Lu  Guangliang Li  Ruiying ChenFirst published: 31 May 2019 https://doi.org/10.1111/coa.13385This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/coa.13385ePDFPDFTOOLS...
Αλέξανδρος Γ. Σφακιανάκης
24m
Does cartilage thickness affect hearing results in real life? long‐term results of cartilage and fascia...
Does cartilage thickness affect hearing results in real life? long‐term results of cartilage and fascia graft in type 1 tympanoplastyM. Tayyar Kalcioglu  Ozan Tuysuz  Muhammed Zeki Yalcın  Erkan KaratasFirst published: 31 May 2019 https://doi.org/10.1111/coa.13383This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version...
Αλέξανδρος Γ. Σφακιανάκης
25m
Cystic Fibrosis–Related Diabetes: Pathophysiology and Therapeutic Challenges Show all authors...
Cystic Fibrosis–Related Diabetes: Pathophysiology and Therapeutic ChallengesShow all authorsRyan Kelsey, Fiona N Manderson Koivula, Neville H McClenaghan, ...First Published May 28, 2019 Review Article https://doi.org/10.1177/1179551419851770Article information   AbstractCystic fibrosis–related diabetes (CFRD) is among the most common extrapulmonary co-morbidity associated with cystic fibrosis (CF), affecting an estimated 50% of adults with the condition. Cystic fibrosis is prevalent in 1 in every...
Αλέξανδρος Γ. Σφακιανάκης
27m
Tumor Size and Overall Survival in Patients With Platinum-Resistant Ovarian Cancer Treated With...
Tumor Size and Overall Survival in Patients With Platinum-Resistant Ovarian Cancer Treated With Chemotherapy and BevacizumabAlexandre Sostelly, François MercierFirst Published May 28, 2019 Research Article https://doi.org/10.1177/1179554919852071Article information   AbstractIntroduction:Ovarian cancer is now recognized as a constellation of distinct subtypes of neoplasia involving the ovary and related structures. As a consequence of this heterogeneity, the analysis of covariates influencing the...
Αλέξανδρος Γ. Σφακιανάκης
27m
Paediatric Cystic Fibrosis Paediatric interview schedule
Paediatric Cystic Fibrosis Paediatric interview scheduleIce Breakers Question's:• Thank you for taking part• What were your first thoughts when you were asked to take part in this research?• Did you have any hesitations about agreeing to take part?• So to begin with, can you describe what you do in a typical day?Weekday/weekend differenceSpare timeImpact of cystic fibrosis on the patient's personal life:• Could you tell me what it is like to live with cystic fibrosisDiscuss the challenges of living...
Αλέξανδρος Γ. Σφακιανάκης
28m
Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung...
Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis: A Retrospective Cohort StudyShow all authorsMasaya Aoki, Tadashi Umehara, Go Kamimura, ...First Published May 28, 2019 Research Article https://doi.org/10.1177/1179554919852087Article information   AbstractBackground:Bone morphogenetic protein-7 (BMP-7) is a signaling molecule belonging to the transforming growth factor-β superfamily. Recent studies have demonstrated that...
Αλέξανδρος Γ. Σφακιανάκης
28m
Paediatric Cystic Fibrosis Paediatric interview schedule
Ice Breakers Question's:• Thank you for taking part• What were your first thoughts when you were asked to take part in this research?• Did you have any hesitations about agreeing to take part?• So to begin with, can you describe what you do in a typical day?Weekday/weekend differenceSpare timeImpact of cystic fibrosis on the patient's personal life:• Could you tell me what it is like to live with cystic fibrosisDiscuss the challenges of living with cystic fibrosisHas it always been this or were other...
Αλέξανδρος Γ. Σφακιανάκης
31m
An Exploration Into Knowledge, Attitudes, and Beliefs Towards Risky Health Behaviours in a Paediatric...
An Exploration Into Knowledge, Attitudes, and Beliefs Towards Risky Health Behaviours in a Paediatric Cystic Fibrosis PopulationRebecca Keyte, Helen Egan, Michail MantziosFirst Published May 30, 2019 Research Article https://doi.org/10.1177/1179548419849427Article information   Article InformationVolume: 13Article first published online: May 30, 2019; Issue published: January 1, 2019Received: November 02, 2018; Accepted: April 13, 2019 Rebecca Keyte, Helen Egan,  Michail MantziosDepartment of Psychology,...
Αλέξανδρος Γ. Σφακιανάκης
33m
Assessing the location and degree of endolymphatic hydrops (EH) in definite Meniere's disease (MD)
Quantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere's disease.pubmed vestibular evoked my..... - 42m ago Preview  AUTO POST SAVE TO EVERNOTERelated ArticlesQuantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere's disease.Eur Arch Otorhinolaryngol. 2019 Apr;276(4):993-1000Authors: Guo P, Sun W, Shi S, Zhang F, Wang J, Wang...
Αλέξανδρος Γ. Σφακιανάκης
35m
Neuronal spiking in the pedunculopontine nucleus in progressive supranuclear palsy and in idiopathic...
Neuronal spiking in the pedunculopontine nucleus in progressive supranuclear palsy and in idiopathic Parkinson's diseaseLatest Results for Journal of Neurology - 42m ago Preview    AUTO POST  SAVE TO EVERNOTEAbstractThe pedunculopontine nucleus (PPN) is engaged in posture and gait control, and neuronal degeneration in the PPN has been associated with Parkinsonian disorders. Clinical outcomes of deep brain stimulation of the PPN in idiopathic Parkinson's disease (IPD) and progressive supranuclear...
Αλέξανδρος Γ. Σφακιανάκης
39m
Loss of ZNF750 in ocular and cutaneous sebaceous carcinomas. pubmed j cutan pathol [jou..... - 41m...
Loss of ZNF750 in ocular and cutaneous sebaceous carcinomas.pubmed j cutan pathol [jou..... - 41m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesLoss of ZNF750 in ocular and cutaneous sebaceous carcinomas.J Cutan Pathol. 2019 May 30;:Authors: North JP, Solomon DA, Golovato J, Bloomer M, Benz SC, Cho RJAbstractBACKGROUND: Sebaceous carcinoma (SeC) is an uncommon malignancy arising from sebaceous glands of the conjunctiva and skin. Recurrent mutations in the ZNF750 were recently identified...
Αλέξανδρος Γ. Σφακιανάκης
39m
Review of genodermatoses with characteristic histopathology and potential diagnostic delay. pubmed...
Review of genodermatoses with characteristic histopathology and potential diagnostic delay.pubmed j cutan pathol [jou..... - 41m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesReview of genodermatoses with characteristic histopathology and potential diagnostic delay.J Cutan Pathol. 2019 May 30;:Authors: Ko CJ, Atzmony L, Lim Y, McNiff JM, Craiglow B, Antaya RJ, Choate KAAbstractAdvances in human genetics have enabled discovery of new genes for inherited skin diseases and cutaneous malformations...
Αλέξανδρος Γ. Σφακιανάκης
40m
Intradermal nevus with osteoclast-like giant cell melanocytes. pubmed j cutan pathol [jou..... -...
Intradermal nevus with osteoclast-like giant cell melanocytes.pubmed j cutan pathol [jou..... - 41m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesIntradermal nevus with osteoclast-like giant cell melanocytes.J Cutan Pathol. 2019 May 30;:Authors: Enos T, Vandergriff TAbstractMultinucleate osteoclast-like giant cells (OLGCs) are histologically distinct and have been described in several cutaneous and extracutaneous lesions.1-9 Notably, these cells are rarely reported to occur in melanoma,...
Αλέξανδρος Γ. Σφακιανάκης
40m
Primary cutaneous acral CD8 (+) T-cell lymphoma of the ear: a case report. pubmed j cutan pathol...
Primary cutaneous acral CD8 (+) T-cell lymphoma of the ear: a case report.pubmed j cutan pathol [jou..... - 41m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesPrimary cutaneous acral CD8 (+) T-cell lymphoma of the ear: a case report.J Cutan Pathol. 2019 May 30;:Authors: Ormerod E, Murigu T, Pawade J, Beasley M, Dunnill GAbstractPrimary cutaneous acral CD8 (+) T-cell lymphoma is a rare, distinct type of cutaneous T-cell lymphoma. Despite its worrisome histological appearance it has a benign...
Αλέξανδρος Γ. Σφακιανάκης
41m
Perianal and perineal keratoacanthoma: two cases demonstrating histologic similarity to subungual...
Perianal and perineal keratoacanthoma: two cases demonstrating histologic similarity to subungual keratoacanthoma.pubmed j cutan pathol [jou..... - 41m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesPerianal and perineal keratoacanthoma: two cases demonstrating histologic similarity to subungual keratoacanthoma.J Cutan Pathol. 2019 May 30;:Authors: Paulson N, Gibson J, Glusac EAbstractPerianal keratoacanthomas are rare, with ten cases reported to date. Perineal keratoacanthoma has not...
Αλέξανδρος Γ. Σφακιανάκης
43m
Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study. pubmed...
Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study.pubmed med oncol [jour].. - 39m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesEffectiveness of a genetic test panel designed for gynecological cancer: an exploratory study.Med Oncol. 2019 May 29;36(7):62Authors: Ida K, Miyamoto T, Higuchi S, Takeuchi H, Yamada S, Ono M, Nishihara H, Shiozawa TAbstractTo increase diagnostic efficiency and cost-effectiveness, we performed an exploratory genetic...
Αλέξανδρος Γ. Σφακιανάκης
43m
Expression of cellular apoptosis susceptibility (CAS) in the human testis and testicular germ cell...
Expression of cellular apoptosis susceptibility (CAS) in the human testis and testicular germ cell tumors.pubmed med oncol [jour].. - 39m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesExpression of cellular apoptosis susceptibility (CAS) in the human testis and testicular germ cell tumors.Med Oncol. 2019 May 29;36(7):61Authors: Liu J, Ye M, Han R, Gui Y, Li X, Zhang H, Wang X, Guo H, Li F, Zhao AZ, Guan K, Chen HAbstractTesticular germ cell tumors are the most frequent malignancies found...
Αλέξανδρος Γ. Σφακιανάκης
44m
THE SUBSTANTIA NIGRA IS PERMISSIVE AND GAINS INDUCTIVE SIGNALS WHEN LESIONED FOR DOPAMINERGIC DIFFERENTIATION...
THE SUBSTANTIA NIGRA IS PERMISSIVE AND GAINS INDUCTIVE SIGNALS WHEN LESIONED FOR DOPAMINERGIC DIFFERENTIATION OF EMBRYONIC STEM CELLS.pubmed stem cells dev [jou..... - 38m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesTHE SUBSTANTIA NIGRA IS PERMISSIVE AND GAINS INDUCTIVE SIGNALS WHEN LESIONED FOR DOPAMINERGIC DIFFERENTIATION OF EMBRYONIC STEM CELLS.Stem Cells Dev. 2019 May 29;:Authors: Collazo-Navarrete O, Hernández-García D, Guerrero-Flores G, Drucker-Colín R, Guerra-Crespo M, Covarrubias...
Αλέξανδρος Γ. Σφακιανάκης
44m
The effects of slow loaded breathing training on exercise blood pressure in isolated systolic hypertension....
The effects of slow loaded breathing training on exercise blood pressure in isolated systolic hypertension.pubmed physiother res int ..... - 38m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesThe effects of slow loaded breathing training on exercise blood pressure in isolated systolic hypertension.Physiother Res Int. 2019 May 29;:e1785Authors: Ubolsakka-Jones C, Tongdee P, Jones DAAbstractOBJECTIVES: Slow loaded breathing training has been shown to reduce resting blood pressure (BP) in...
Αλέξανδρος Γ. Σφακιανάκης
45m
Microvesicles derived from TGF-β1 stimulated hepatic stellate cells aggravate hepatocellular injury....
Microvesicles derived from TGF-β1 stimulated hepatic stellate cells aggravate hepatocellular injury.pubmed stem cells dev [jou..... - 38m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesMicrovesicles derived from TGF-β1 stimulated hepatic stellate cells aggravate hepatocellular injury.Stem Cells Dev. 2019 May 29;:Authors: Liang Y, Pan Q, Wang R, Ye Z, Li Z, Zeng L, Chen Y, Ma X, Li M, Miao HAbstractHepatic stellate cells (HSCs) are liver specific cells playing critical roles in liver physiological...
Αλέξανδρος Γ. Σφακιανάκης
45m
The atrioventricular junction - a potential niche region for progenitor cells in the adult human...
The atrioventricular junction - a potential niche region for progenitor cells in the adult human heart.pubmed stem cells dev [jou..... - 38m ago Preview    AUTO POST  SAVE TO EVERNOTERelated ArticlesThe atrioventricular junction - a potential niche region for progenitor cells in the adult human heart.Stem Cells Dev. 2019 May 31;:Authors: Vukusic K, Sandstedt M, Jonsson M, Jansson M, Oldfors A, Jeppson A, Dellgren G, Lindahl A, Sandstedt JAbstractA stem cell niche is a microenvironment where stem...
Αλέξανδρος Γ. Σφακιανάκης
46m
Πως να «νικήσετε» το άγχος των εξετάσεων Ψυχο-γραφήματα by Ρεβέκκα Τσοχαντάρη - 18m ago Preview  ...
Πως να «νικήσετε» το άγχος των εξετάσεωνΨυχο-γραφήματα by Ρεβέκκα Τσοχαντάρη - 18m ago Preview    AUTO POST  SAVE TO EVERNOTEΟι επιστημονικοί συνεργάτες της Γραμμής 115 25 του Μαζί για το Παιδί δίνουν συμβουλές σε εφήβους και γονείςΤη στιγμή των εξετάσεων η Κατερίνα παίρνει τα θέματα και παθαίνει μπλακ-αουτ.Προετοιμασία μηνών φαίνεται να πηγαίνει στράφι  λόγω του άγχους που την διακατέχει εκείνη τη στιγμή. Η κρίση πανικού είναι κοντά. Ο χρόνος που της δίνεται για να απαντήσει μοιάζει πιο πολύ να...
Αλέξανδρος Γ. Σφακιανάκης
1h
Listeria detected in sandwich Food Safety News » Food Recalls by News Desk - 8m ago Preview     AUTO...
Listeria detected in sandwichFood Safety News » Food Recalls by News Desk - 8m ago Preview    AUTO POST  SAVE TO EVERNOTEAir France has issued a warning after Listeria was detected in tuna sandwiches served on certain flights in May. Servair, the supplier of the airline's on-board catering service, reported the pathogen was found in the sandwiches from self-service on-board buffets.It was revealed during quality check procedures on foodstuffs distributed aboard Air France flights.The sandwich was...
Αλέξανδρος Γ. Σφακιανάκης
1h
Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory...
Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory symptoms of chemotherapy-induced peripheral neuropathy—a randomized controlled pilot trialAbstractChemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically relevant side effect of chemotherapy. The symptoms diminish patients' quality of life and represent a decisive limiting factor for medical therapy. To date, effective treatment options are lacking. Specific exercise interventions...
Αλέξανδρος Γ. Σφακιανάκης
1h
Are topical beta-blockers really effective "in real life" for targeted therapy-induced paronychia...
Are topical beta-blockers really effective "in real life" for targeted therapy-induced paronychiaAbstractParonychia and periungual pyogenic granuloma represent one of the most common and bothersome dermatologic toxicities observed with ErbB inhibitors. There is no standardized treatment, and management remains challenging. Moreover, conservative management with noninvasive treatment should be promoted for fragile patients in a metastatic setting. Over the last few years, the efficacy of topical blocking...
Αλέξανδρος Γ. Σφακιανάκης
1h
Supportive Care
Inter-rater reliability of the Oral Assessment Guide for oral cancer patients between nurses and dental hygienists: methodological issueAre topical beta-blockers really effective "in real life" for targeted therapy-induced paronychiaAbstractParonychia and periungual pyogenic granuloma represent one of the most common and bothersome dermatologic toxicities observed with ErbB inhibitors. There is no standardized treatment, and management remains challenging. Moreover, conservative management with noninvasive...
Αλέξανδρος Γ. Σφακιανάκης
1h
Genetics
Artificial Selection for Reduced Fitness in Panmictic Populations of Drosophila melanogasterAbstractWe investigated the evolution of the panmictic experimental populations of Drosophila melanogaster under the influence of artificial selection for reduced fitness. Slowly developing flies were selected among offspring from parents with low sexual activity and low fecundity. As result of this selection carried out for 16 generations, there was a strong decline in the various components of fitness. Our...
Αλέξανδρος Γ. Σφακιανάκης
1h
Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Paediatric Cystic Fibrosis Paediatric interview schedule

Paediatric Cystic Fibrosis Paediatric interview schedule



  • Ice Breakers Question's:
  • • Thank you for taking part
  • • What were your first thoughts when you were asked to take part in this research?
  • • Did you have any hesitations about agreeing to take part?
  • • So to begin with, can you describe what you do in a typical day?
    • Weekday/weekend difference
    • Spare time
  • Impact of cystic fibrosis on the patient's personal life:
  • • Could you tell me what it is like to live with cystic fibrosis
    • Discuss the challenges of living with cystic fibrosis
    • Has it always been this or were other aspects/things more difficult to cope with when you was younger?
  • Do you tell others about your cystic fibrosis?
    • Who do you tell?
    • What do you tell them?
    • How do you find telling others about your cystic fibrosis?
    • Why don't you tell others about your cystic fibrosis?
  • How do you find it sticking to your treatment regimen?
    • Does anyone help you stick to your regimen? (Who?)
    • Are there any aspects that are more difficult to stick to?
    • Has this changed over time?
    • Does it change depending on the situation/circumstances?
    • Are there any treatments you tend to 'miss out'?
    • Are there any treatments you wish you could 'miss out'?
    • How do you think it would make you feel if you did miss those treatments out?
  • Barriers to Adherence:
  • • What things make it difficult to stick to the regimen?
Areas for further elaboration may include:
  • Not enough time in the day with school, etc
  • The belief that the medical regimen is not benefitting them
  • Are they self-prescribing according to their symptoms?
  • Weekday/weekend difference
  • Are there any situations where you are less likely to take your medication/complete your, eg, physiotherapy?
Areas for further elaboration may include:
  • At school
  • At a friend's house
  • What makes it harder to complete your regimen in these situations?
  • An area for further exploration may include the identity the medical regimen provides them with
Risky Health Behaviours:
  • When I say 'risky behaviours', what does that make you think of?
  • Do you think that some things are more risky for you because of your cystic fibrosis?
  • What things would 'not be good' for your health?
Examples may include:
  • Smoking
  • Drugs
  • Drinking alcohol
  • Do you feel that these behaviours would have an impact on your cystic fibrosis?
  • Have you ever been told that any of these behaviours would be bad for your cystic fibrosis?
    • Who has provided you with this awareness?
    • How does it make you feel towards these behaviours?
  • Do you know anyone who takes part in these behaviours?
    • Who?
    • How does that make you feel?
  • Have you/would you ever be motivated to try one of these behaviours?
    • What would motivate you?
    • What would stop you?
  • Why do you think people do engage in these behaviours?
  • Do you think any cystic fibrosis patients engage in risky behaviours?
    • Why do you think a cystic fibrosis patient would engage in these behaviours?
    • Why do you think a cystic fibrosis patient would not engage in these behaviours?
  • Family and Friends:
  • • If you did (eg, smoke), would you be open with family and friends about your (eg, smoking?) What do you think they would think about it? What would their reaction be?
'Other' may include
  • Parents
  • Siblings
  • Partner
  • Who do you go to with any concerns regarding your cystic fibrosis?
Examples may be:
  • Consultants
  • Family
  • Friends
  • Online forums
  • Do you ever speak to any other cystic fibrosis patients?
    • Is this online?
    • Is this face to face?
  • Conclusion:
  • • What would you want to tell a younger patient with cystic fibrosis?
    • eg, about going to school with cystic fibrosis
    • eg, about telling others about their cystic fibrosis
  • What would you tell a family who had just had a child with cystic fibrosis?
  • Honestly if you were to have this discussion with another person (eg, someone who has cystic fibrosis), outside of this research, would this conversation be the same?
  • Do you have anything else to add?

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Assessing the location and degree of endolymphatic hydrops (EH) in definite Meniere's disease (MD)

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Quantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere's disease.

Eur Arch Otorhinolaryngol. 2019 Apr;276(4):993-1000

Authors: Guo P, Sun W, Shi S, Zhang F, Wang J, Wang W

Abstract
PURPOSE: To help clinicians to further understand the significance of vestibular-evoked myogenic potential (VEMP) examinations to diagnose MD and the quantitative relationship between VEMP and MRI in assessing the location and degree of endolymphatic hydrops (EH) in definite Meniere's disease (MD) patients.
METHODS: Fifty-six patients with unilateral definite MD participated in this study, which used MRIs through intravenous gadolinium administration (IV-Gd), audiometry, caloric tests and VEMP tests. The VEMP results of 26 healthy volunteers were used as a normal reference value.
RESULTS: The participants were found through MRI to have differing degrees of vestibular and cochlear EH. Quantitative comparison of MRI and VEMP results found that the response rates of oVEMP decreased with cochlear EH increasing; the asymmetry ratio (AR) of oVEMP can be used to find whether cochlear EH or not, and the P1-N1 amplitude was lower in the extreme cochlear EH group (P < 0.01). The AR of cVEMP was larger in severe vestibular EH group than that of the mild or no vestibular EH group (P < 0.01). The correlation between the degree of cochlear EH and the mean PTA threshold was statistically significant (P < 0.05). The duration of MD correlated positively with vestibular EH (P < 0.05). The abnormal rate of caloric tests was higher in severe vestibular EH group than that of the mild or no vestibular EH group (P < 0.05).
CONCLUSIONS: The advantages of MRIs by IV-Gd administration were obvious in assessing the location and degree of EH. oVEMP and PTA can be indirectly used to evaluate the extent of cochlear EH, cVEMP and caloric tests can be used to assess the extent of vestibular EH on the condition of absent MRIs.

PMID: 30694377 [PubMed - indexed for MEDLINE]

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Supportive Care

Inter-rater reliability of the Oral Assessment Guide for oral cancer patients between nurses and dental hygienists: methodological issue


Are topical beta-blockers really effective "in real life" for targeted therapy-induced paronychia

Abstract

Paronychia and periungual pyogenic granuloma represent one of the most common and bothersome dermatologic toxicities observed with ErbB inhibitors. There is no standardized treatment, and management remains challenging. Moreover, conservative management with noninvasive treatment should be promoted for fragile patients in a metastatic setting. Over the last few years, the efficacy of topical blocking agents has been considered for managing cutaneous or mucosal pyogenic granulomas. Very recently, the use of topical propranolol or of timolol has been reported in several patients undergoing treatment with EGFR inhibitors and developing pyogenic granulomas of the nail. We performed a retrospective single-center review of patients with targeted therapy-related paronychia/periungual pyogenic granulomas who had been treated with topical timolol, either alone or in combination with other topical treatments. Nearly two thirds of patients showed at least a partial response after 1 month of therapy, and the use of a topical beta-blocker in our population was associated with a favorable safety profile. Finally, topical timolol may represent a promising treatment option for the management of cancer patients suffering from painful periungual lesions. Comparative clinical trials, however, are still needed.



Social support buffers against anxiety and depressive symptoms in patients with cancer only if support is wanted: a large sample replication


Combined exercise and nutritional rehabilitation in outpatients with incurable cancer: a systematic review

Abstract

Purpose

The optimal components for rehabilitation in patients with incurable cancer are unclear. However, principles of exercise and nutrition-based interventions used in cancer cachexia may be applied usefully to this population of cancer patients. This systematic review examines current evidence for rehabilitation combining exercise and nutritional support in patients with incurable cancer.

Methods

MEDLINE, EMBASE and Cochrane databases were searched. Eligible studies included patients with incurable cancer and rehabilitation programmes combining exercise and nutritional interventions. Studies of cancer survivors, curative treatments, reviews, case note reviews, protocols and abstracts were excluded. Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria were applied to patient-important outcomes.

Results

Of the 2424 search results, 67 abstracts were reviewed and 24 full texts examined. Eight studies (n = 685) were included comprising two randomised control trials, three prospective, one exploratory and two secondary analyses. All examined multi-modal outpatient programmes. GRADE analysis revealed moderate evidence (B) for improvements in depression and physical endurance, low-quality evidence (C) for quality of life and fatigue and very low–quality evidence (D) for overall function and nutritional status.

Conclusion

There are limited data for multi-modal rehabilitation programmes combining exercise and nutritional interventions in patients with incurable cancer. However, studies to date report improvements in multiple domains, most notably physical endurance and depression scores. This supports the concept that multi-modal rehabilitation incorporating principles of cachexia management may be appropriate for the wider group of patients with incurable cancer. Further, high-quality studies are needed to define the optimal approach and outcome measures.



Toward the development of a comprehensive cancer experience measurement framework

Abstract

A diagnosis of cancer and its treatment often have a profound impact on an individual's health-related quality of life—affecting physical, psychological, social, occupational, and financial domains. Person-centered care (PCC)—defined as a respectful, responsive, and tailored approach that meets patients' needs, values, and preferences—is becoming an integral part of comprehensive cancer care. The implementation of PCC into clinical practice provides benefits such as improvement in the quality of patient care, enhanced health-related outcomes, and significantly higher satisfaction with care. However, to guide and document more precisely the effects of PCC, various authors have argued that a more comprehensive measurement framework is needed. The primary goal of this paper is to present such an evolving framework based on extant evidence and developed in the context of a series of expert stakeholder meetings spearheaded by the Canadian Partnership Against Cancer (CPAC) that began in 2012. Developed collaboratively, the Cancer Experience Measurement Framework goes beyond existing patient experience frameworks by focusing on four key elements and related measures: the patient perspective, the family perspective, the combined patient-family perspective, and interactions with the healthcare system. In light of current healthcare trends promoting cancer self-management, patients as partners, and patient and family engagement in care, it is imperative that we conduct ongoing assessments using shared and psychometrically sound measures to ensure sound comparisons across settings, as well as better cancer-related processes and outcomes for indivduals affected by cancer.



Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory symptoms of chemotherapy-induced peripheral neuropathy—a randomized controlled pilot trial

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically relevant side effect of chemotherapy. The symptoms diminish patients' quality of life and represent a decisive limiting factor for medical therapy. To date, effective treatment options are lacking. Specific exercise interventions have proven promising to target relevant symptoms. We conducted a prospective, four-armed, randomized, controlled trial, to evaluate the effects of sensorimotor training (SMT) and whole-body vibration training (WBV) on patients with CIPN. Participants (N = 40) were randomized to either one of two intervention groups (SMT N = 10 or WBV N = 10) or oncological control group (N = 10) and matched by gender and age with a healthy control (N = 10). The intervention groups exercised twice a week for 6 weeks. Primary endpoint was the reduction of CIPN-related symptoms (improve peripheral deep sensitivity, Achilles tendon reflex (ASR) and patellar tendon reflex (PSR), light-touch perception, sense of position, and lower leg strength). Secondary endpoints were nerve conduction velocity and amplitude, balance control, quality of life, and CIPN-related pain. Patients exercising improved sensory and associated motor symptoms. Significant intergroup differences were found for the tendon reflexes (ASR P = .017 and PSR P = .020), peripheral deep sensitivity (P = .010), and pain (P = .043). Furthermore, tendencies were found regarding the subjective improvement of symptoms (P = .075) and two subscales of the EORTC-QLQ-C30 questionnaire: pain (P = .054) and dyspnea (P = .054). The results for the SMT group were superior regarding the tendon reflexes, and a tendency regarding the subjective report of symptoms, while WBV was superior regarding pain. SMT and WBV behold a large potential to reduce CIPN-related symptoms and can be considered feasible and safe for patients with CIPN (compliance 97.5%, no adverse events).

Registration: DRKS00013027



Sexual desire of French representative prostate cancer survivors 2 years after diagnosis (the VICAN survey)

Abstract

Purpose

The prostate cancer impacts on the future life of survivors. The complexity of sexual health problems in prostate cancer survivors is underestimated or often reduced to the erectile dysfunction. Especially, factors influencing sexual desire of patients have to be more explored. This study aims to describe the therapeutic management of patients with prostate cancer and assess their sexual desire 2 years after diagnosis.

Methods

This study is part of the National VICAN survey (Vie après le CANcer) implemented in France in 2012. This analysis was performed on a population of 414 men who had prostate cancer. The questionnaire dealt with several topics including socioeconomic status, treatments received, and sexual desire.

Results

Prostatectomy (42.8%), radiotherapy + hormonotherapy (17.6%), and radiotherapy alone (12.8%) were the main treatments used. 41.3% of men stated that their sexual desire was all gone since disease. The "satisfying" perceived financial situation was significantly associated to a sexual desire loss (p = 0.008). Radiotherapy + hormonotherapy treatment only is significantly associated with a loss of sexual desire (P = 0.003).

Conclusions

Two years after diagnosis, the sexual desire of prostate cancer survivors is deteriorated with the cancer experience. However, clinical characteristics do not seem to be decisive unlike a "satisfying" financial situation. Research about the impact of socio economics characteristics on sexual health should probably be engaged. Programs have to be developed in France to have personalized sexual support progressed for survivors and take spouses into consideration in this context.



Early 7-day supplemental parenteral nutrition improves body composition and muscle strength in hypophagic cancer patients at nutritional risk

Abstract

Purpose

The international guidelines recommend the use of supplemental parenteral nutrition (SPN) in cancer patients when they are malnourished and hypophagic and where enteral nutrition is not feasible. However, there are limited data on the short-term effects of SPN in this patient population.

Methods

The aim of this bicentric single-arm clinical trial (NCT02828150) was to evaluate the effects of early 7-day SPN on bioimpedance vectorial analysis (BIVA)–derived body composition, handgrip strength (HG), and serum prealbumin (PAB) in 131 hypophagic, hospitalized cancer patients at nutritional risk, with contraindications for enteral nutrition.

Results

One hundred eighteen patients (90.1%) completed the 7-day SPN support regimen and 102 of them (86.4%) were in advanced disease stage.

SPN induced a significant improvement of phase angle (PhA, + 0.25 [95% CI 0.11, 0.39]; p = 0.001), standardized phase angle (SPA, + 0.33 [95% CI 0.13, 0.53]; p = 0.002), HG (+ 2.1 kg -95% CI 1.30, 2.81]; p < 0.001), and PAB (+ 3.8 mg/dL [95% CI 2.1, 5.6]; p < 0.001).

In multivariable analysis, the effects on BIVA parameters were more pronounced in patients (N = 90, 76.3%) in whom estimated protein and calorie requirements were both satisfied (adjusted difference: PhA, + 0.39 [95% CI 0.04, 0.73]; p = 0.030; SPA, + 0.62 [95% CI 0.16, 1.09]; p = 0.009).

No significant changes in hydration status were detected and no severe metabolic or other complications occurred.

Conclusions

Early 7-day SPN resulted in improved body composition, HG and PAB levels in hypophagic, and hospitalized cancer patients at nutritional risk in the absence of any relevant clinical complications. Further trials, aimed at verifying the efficacy of this early nutritional intervention on mid- and long-term primary clinical endpoints in specific cancer types, are warranted.



Early Skeletal Muscle Loss in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation and Relationship to Survival

Abstract

Purpose

Sarcopenia is associated with reduced survival in cancer. Currently, data on sarcopenia at presentation and muscle loss throughout treatment are unknown in patients receiving chemoradiation therapy (CRT) for non-small cell lung cancer (NSCLC). This study evaluated skeletal muscle changes in NSCLC patients receiving CRT and relationship with survival.

Methods

Secondary analysis of 41 patients with NSCLC treated with CRT assessed for skeletal muscle area and muscle density by computed tomography pre-treatment and 3 months post-treatment. Images at week 4 of treatment were available for 32 (78%) patients. Linear mixed models were applied to determine changes in skeletal muscle over time and related to overall survival using Kaplan-Meier plots.

Results

Muscle area and muscle density decreased significantly by week 4 of CRT (− 6.6 cm2, 95% CI − 9.7 to − 3.1, p < 0.001; − 1.3 HU, 95% CI − 1.9 to − 0.64, p < 0.001, respectively), with minimal change between week 4 of CRT and 3 months post-CRT follow-up (− 0.2 cm2, 95% CI − 3.6–3.1, p = 0.91; − 0.27, 95% CI − 0.91–0.36, p = 0.36, respectively). Sarcopenia was present in 25 (61%) and sarcopenic obesity in 6 (14%) of patients prior to CRT, but not associated with poorer survival. Median survival was shorter in patients with low muscle density prior to treatment although not statistically significant (25 months + 8.3 vs 53 months + 13.0, log-rank p = 0.17).

Conclusion

Significant loss of muscle area and muscle density occurs in NSCLC patients early during CRT. A high proportion of patients are sarcopenic prior to CRT; however, this was not significantly associated with poorer survival.



Factors influencing neck and shoulder function after oral oncology treatment: a five-year prospective cohort study in 113 patients

Abstract

Background

The aim of this study was to identify factors influencing shoulder and/or neck function in patients up to five years after treatment.

Materials and methods

Lateral flexion of the neck, ipsilateral forward flexion, and abduction of the shoulder were measured. Potential factors were entered into a linear mixed model analysis to create a multivariate model for describing the results.

Results

Predicted neck and shoulder function was negatively influenced by higher age before intervention. Contralateral flexion of the neck was lower for patients undergoing surgery and radiotherapy compared to surgery. Ipsilateral flexion of the neck is influenced by a higher age at baseline. Ipsilateral shoulder abduction is lower for female gender, bone graft/flap reconstruction, and more extensive neck dissection. Ipsilateral forward flexion of the shoulder is lower for bone graft/flap reconstruction and better for patients with a T2 tumor in comparison to T3 and T4 tumors, as predicted.

Conclusion

By our five-year follow-up outcomes of this study, neck and/or shoulder impairments can be found for high-risk patients by physiotherapists.



Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Genetics

Artificial Selection for Reduced Fitness in Panmictic Populations of Drosophila melanogaster

Abstract

We investigated the evolution of the panmictic experimental populations of Drosophila melanogaster under the influence of artificial selection for reduced fitness. Slowly developing flies were selected among offspring from parents with low sexual activity and low fecundity. As result of this selection carried out for 16 generations, there was a strong decline in the various components of fitness. Our results confirm the results of the experiments by Kaidanov and his staff. The more rapid decrease in fitness observed by us seems to be due to the use of panmictic populations instead of inbred lines. Thus, the resulting fly selection observed in our studies likely reflects a preexisting genetic variation, rather than new mutations.



Mutations in the Insulin Signaling Pathway Genes Affect Carbohydrate Level under Heat Stress in Drosophila melanogaster Females

Abstract

The effect of the following insulin signaling pathway genes on carbohydrate content under normal and heat stress conditions in Drosophila melanogaster females is studied: transcription factor Forkhead box class O (dfoxo) and insulin-like peptide DILP6 (dilp6), which is synthesized in the fat body. The hypomorphic mutations dilp641 and foxoBG01018 are shown to result in an increase in glucose and trehalose levels under normal conditions. For the first time, a sharp decline in the expression level of dilp6 and dfoxo genes caused by these mutations is demonstrated not to prevent the increase in the levels of both sugars under heat stress, but reduce the intensity of this response.



Phylogenetic Analysis of Yersinia pestis Strains of the Caucasian Subspecies from the Foci of the Caucasus and Transcaucasia according to the Whole Genome Sequencing Data

Abstract

We have investigated the population structure of Yersinia pestis spp. caucasica strains from natural plague foci located in the Caucasus and Transcaucasia. According to the data of a whole genome SNP analysis of 28 strains of the Caucasian subspecies, seven of which are sequenced by us, and taking into account 1625 identified core SNPs, the presence of several phylogenetic lines and populations of Yersinia pestis ssp. caucasicacorresponding to the geographical distribution of the strains has been determined. Strains of Y. pestis Caucasian subspecies include three separate clusters, the first of which is represented by strains from the East Caucasian high-mountain plague focus. Their genome has revealed 80 unique SNPs, which indicates their greatest antiquity and the long-standing divergence of this branch from the common stem of the evolution of Caucasian strains. The genomes of strains of two other clusters also differ in a large number of individual SNPs, 32 and 36, respectively. One of them includes strains from the Pre-Sevan mountain, Zangezur-Karabakh mountain, and Pre-Araks low-mountain foci with the grouping within the cluster of three separate subclusters: Pre-Sevan (IIa), Zangezur-Karabakh (IIb), and Zangezur-Karabakh-Pre-Araks (IIc). Another one, the third cluster of the Caucasian subspecies, consists of strains from the northwestern part of the Caucasus highlands (Gyumri and Javakheti-Akhalkalaki foci). Using PCR with hybridization-fluorescent registration of results and whole genome sequencing, two clinical strains of Y. pestis were shown to belong to the Caucasian subtype, which confirms the ability of this subspecies to cause plague in humans.



Relationship of Bovine Lymphocyte Antigen Genes with Clinical Mastitis Disease Using SSCP Technique

Abstract

BoLA-A and BoLA-DRB3 are in class I and II genes of bovine lymphocyte antigen of immune system respectively which cattle express per haplotype. The aim of this study was to evaluate relationship of BoLA-A and BoLA-DRB3 polymorphisms with clinical mastitis disease using SSCP technique. In the current study, blood sampling was carried out from Holstein cattle (n = 50 susceptible and n = 50 resistant to clinical mastitis) and a random sampling was conducted from Iranian native cattle (Sarabi; n = 50). Amplification of exon 2 of BoLA-DRB3 and BoLA-A genes by specific primers was used for SSCP technique. SSCP technique successfully able to detect some pattern is related to clinical mastitis disease in BoLA-DRB3.2 region as well as genotype pattern of C was observed significantly (P < 0.05) in susceptible Holstein cattle in compared to others pattern. Also, B and Q genotypes patterns of SSCP were detected only in susceptible cattle. Also, SSCP results were showed 17 genotypes pattern in Holstein and 17 different genotypes pattern in Sarabi cattle in BoLA-DRB3.2 gene. Thus, our finding indicated that Sarabi breed comprises completely different allelic in the BoLA-DRB3.2 region compared to Holstein breed. Moreover, results of this study revealed that exon 2 of BoLA-A showed lack of polymorphism in both studied breed. This is the first study on characterization of exon 2 of BoLA-A‎gene using SSCP technique in bovine.‎



Quasi Linkage Equilibrium under Weak Two-Locus Viability Selection: I. Haploid Population with Diallelic Loci

Abstract

A model of weak viability selection at two diallelic loci with standardization of approaches through the use of perturbation theory is examined. The estimate of the quasi-equilibrium value for the linkage disequilibrium coefficient D is analyzed, and results in terms of average effects in quantitative genetics and in terms of the theory of singular perturbations in mathematics are obtained. The approximation of a discrete-time model of a random mating population with non-overlapping generations under weak selection by ordinary differential equations is considered. Weak selection is considered as a perturbation of the model without selection. The resulting model is singularly perturbed; that is, fast (D) and slow (allele frequencies) variables can be distinguished. The first approximation equation for quasi-equilibrium of D is obtained using the first terms of the Taylor series expansion of the model functions. It coincides with the corresponding part of the system of the first approximation of the asymptotic series for solving singularly perturbed equations. The first approximation for quasi-equilibrium of D is D* = ε(p) \(\frac{\mu }{r}\) x(1 – xy(1 – y), ε(p) ≡ v11(p) – v12(p) – v21(p) + v22(p), where μ is the intensity of selection, r is the recombination coefficient, ε(p) is the index of epistasis nonadditivity for the viabilities \({{{v}}_{{{{i}_{{\text{1}}}}{{i}_{{\text{2}}}}}}}\) x and y are the allele frequencies of the first and second locus, respectively. The evolution of a nonequilibrium state of the population actually takes place at quasi-equilibrium (as the result of the stage of fast variable D dynamics) and current values of slow xy.



A Study on the Effect of Prolactin Gene Variants on Milk Production Traits of Holstein Cattle

Abstract

Recent studies aiming to improve the daily milk production of cattle using both genetic and environmental factors are extremely important. The aim of this study is to determine the possible relationships between daily milk production and polymorphic distribution of exon 3 region of the prolactin (PRL) gene, which is an important marker for selection. With this purpose, 155 Holstein cows were included in the study, and the demographic data of the cattle were recorded. Venous blood was collected from the jugular vein of cows in 2 tubes of 2 mL each containing EDTA for DNA isolation. Genomic DNA were isolated from these whole blood samples. The prolactin gene region of the cattle were identified using PCR/RFLP and Sanger DNA sequencing method. The genotype, allele frequencies and Hardy–Weinberg equilibrium were calculated using Arlequin version 3.5.1.3 package software. Accordingly, it was found that cows with genotype AA had statistically higher milk yield as compared to those with genotype AB and BB. Missense mutation, frameshift and silent mutations were detected in the prolactin gene exon 3. It was also found that cows with missense mutation had statistically lower milk fat percentage as compared to the others. Consequently, the effects of genotypic distribution and mutation in the prolactin gene on the milk production of Holstein cows, which is a special breed in terms of milk productivity, have been revealed.



Molecular-Genetic Polymorphism of Puccinia triticina in Southern Dagestan Relating to the Center of the Common Evolution between Agent Causing Leaf Rust and Wheat

Abstract

Intraspecific genetic polymorphism of leaf rust caused by Puccinia triticina Erikss. was evaluated on the basis of the virulence, microsatellite loci (SSR), and single nucleotide polymorphism (SNP) of isolates collected in Southern Dagestan from species of Triticum L. sp. and Aegilops L. sp. Existence of pathogen population differentiation according to the results of virulence and microsatellite analysis indicates the existence of several genetically differing groups of isolates within the Derbent population. Derbent isolates and reference isolates of P. triticina from durum and common wheat that originated from different countries were characterized by a high degree of phylogenetic relationship by SNP markers. Ethiopian durum isolates in contrast were separated in a single clade.



Association between Allelic Variants of IL2 , IL2RA , and IL7R Genes and Multiple Sclerosis

Abstract

Multiple sclerosis is a chronic progressive disease of nervous system caused by a combination of genetic and environmental factors leading to the development of a complex of autoimmune and neurodegenerative processes. We performed the analysis of association between multiple sclerosis and polymorphic markers of interleukin-2 (IL2), interleukin-2 receptor alpha chain (IL2A) and interleukin-7 receptor alpha chain (IL7R) in the group of Russians, Tatars, and Bashkirs from the Republic of Bashkortostan (N = 1620). In the total study group, we detected the association of IL7R rs10624573*I (OR = 0.79, PBonf = 0.018) and rs1494558*T (OR = 1.44, PBonf = 2.33 × 10–4) variants with multiple sclerosis. When analyzed separately according to the ethnic origin, the association with IL7R rs1494558*T (OR = 1.49, PBonf = 0.005) remained significant in the group of Russians, and the association of IL7R rs10624573*I remained significant in the group of Bashkirs (OR = 0.56, PBonf = 0.02). We performed the multilocus analysis of association using the APSampler algorithm, and found seven combinations of the alleles and/or genotypes of the studied polymorphic loci, significantly associated with multiple sclerosis, most frequently including IL7R rs1494558 and IL7R rs10624573 allelic variants.



Development of Nuclear Microsatellite Markers with Long (Tri-, Tetra-, Penta-, and Hexanucleotide) Motifs for Three Larch Species Based on the de novo Whole Genome Sequencing of Siberian Larch ( Larix sibirica Ledeb.)

Abstract

Siberian larch (Larix sibirica Ledeb.) is one of the major boreal tree species in Eurasia and has a considerable economic and ecological value. Despite that importance, the development and use of microsatellite markers in this species remain limited. Microsatellite markers are considered to be a valuable tool for estimation of population diversity and structure. Availability of a draft reference assembly of the Siberian larch genome allowed us to identify 1015 microsatellite loci or simple sequence repeats (SSRs) with tri-, tetra-, penta-, and hexanucleotide motifs. For 60 of them PCR primers were designed and tested for amplification in L. sibirica and for their within-genus transferability to L. gmelinii (Rupr.) Rupr. and L. cajanderi Mayr. Here, we present a set of 14 reliable and polymorphic new nuclear SSR markers that can be used for further population genetic studies, breeding programs, and timber origin identification.



An Analysis of the Associations of Polymorphic Variants of the LEPR (rs1137100), LRP5 (rs3736228), and LPL (rs320) Genes with the Risk of Developing Type 2 Diabetes Mellitus

Abstract

Diabetes mellitus is a hereditary predisposed multifactorial disease. However, the genetic mechanisms of its development have not been fully revealed yet. We conducted a search for associations of polymorphic variants of the LEPR (rs1137100), LRP5 (rs3736228), and LPL (rs320) genes involved in the development of obesity with the development of type 2 diabetes mellitus. The association with development of the disease was established for the T allele of the LRP5 locus (rs3736228) (p = 0.029, OR = 1.46). The rs1137100 locus (p = 0.032) of the LEPR gene was shown to be associated with the body mass index (BMI), but it was not connected with the presence of type 2 diabetes mellitus. Risk markers of development of type 2 diabetes included the T allele of the rs3736228 locus of the LRP5 gene (OR = 1.74, p = 0.012) and the G allele of the rs320 locus of the LPLgene (OR = 1.39, p = 0.027). Statistically significant association was only found in the group of nonobese patients. A decrease in the level of low-density lipoprotein was observed in individuals with the TT genotype of the LPL locus (rs320) (p = 0.04). Individuals with the GT and GG genotypes of this locus had a lower cholesterol level (p = 0.027). A decrease in the level of BMI (p = 0.012) and a decrease in the concentration of triglycerides in the blood (p = 0.00000004) were detected in carriers of the CC genotype of the LRP5 rs3736228 locus.



Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

CardioVascular and Interventional Radiology

Correction to: Impact of Patient and Lesion Characteristics on Drug-Coated Balloon Angioplasty in the Femoropopliteal Artery: A Pooled Analysis of Four Randomized Controlled Multicenter Trials

In their recently published pooled analysis of four drug-coated balloon (DCB) studies, which focused on the impact of patient and lesion characteristics on LLL at 6 months (Albrecht T et al. Cardiovasc Intervent Radiol. 2018 Dec 11. https://doi.org/10.1007/s00270-018-2137-3), the authors reported slightly inaccurate 2-year mortality rates.



Bariatric Arterial Embolization for Overweight Patients: A New Exploration for Ideal Patients?


A Very Unlucky Intraoperative Event During a Chimney Technique for Juxtarenal Aneurysm Exclusion

Abstract

A two-vessel Ch-EVAR procedure was scheduled within the instructions for use of the devices. After deploying, it appeared that the long sheath inserted through an arm access was discovered to be trapped behind the aortic stentgraft barbs. Trying to remove the sheath, the graft was displaced upward and the procedure was converted for a three-vessel Ch-EVAR incorporating the superior mesenteric artery. Simultaneous ballooning of the target vessels and the stentgraft permitted to exert a strong pullback traction on the blocked sheath, allowing its removal. A segment of the sheath distal end was left trapped in the aortic stentgraft. At 12 months follow-up, the patient is free of any complications and there are no occlusions of the abdominal visceral branches or embolic events in peripheral arteries.



Fluoroscopic Guided Transluminal Biopsy of the Oesophagus and Ureter with a Biliary Biopsy Forceps Kit


Neuroendocrine Liver Metastases


Monomelic Ischemic Neuropathy of the Tibial and Peroneal Nerve After Onyx Embolization of Vasa Nervorum Supplying a Surgically Excluded Popliteal Artery Aneurysm

Abstract

Ischemic neuropathy is an exceedingly rare complication after peripheral artery embolization. We report a case of ischemic damage to the tibial and peroneal nerve after embolization of the vasa nervorum that served as feeding collaterals to a surgically excluded popliteal artery aneurysm.



Stenting the Upper/Cervical Oesophagus with a Proximal Deployment Cervical Oesophageal Stent: Technique and Outcomes

Abstract

Introduction

Proximal oesophageal stent deployment continues to provide challenges due to the proximity of the upper oesophageal sphincter and the associated subsequent complications such as globus sensation and stent migration. Patients with cervical oesophageal cancer have previously had limited stenting options available to them with a paucity of the literature describing the radiological technique for successfully placing these high-risk stents. In this paper, we present our experience using the Taewoong Niti-S CERVICAL Oesophageal Stent.

Materials and Methods

We describe our method for stent deployment highlighting the importance of pre-procedural planning in ensuring an adequate proximal landing zone for the short proximal flare of the stent. Furthermore, we outline how we have adapted our placement technique to incorporate a routine pre-dilatation stage which has optimised retrieval of the proximal to distal deployment system.

Results

We have placed eight cervical oesophageal stents within our institution. Contrast swallows in all the patients following stent deployment have demonstrated free flow of contrast to the stomach with all patients reporting symptomatic relief and no foreign body/globus sensation. There has been one episode of stent migration but no incidence of oesophageal perforation or haemorrhage.

Discussion

Evolution of stenting technique and the properties of the stents themselves are improving accuracy of stent placement in relation to the important landmark of the upper oesophageal sphincter.

Conclusion

Stenting of cervical oesophageal malignancy has proved successful in our institution and provided symptom relief for a subset of palliative patients who were previously unable to benefit from oesophageal stenting.



The Truth on Paclitaxel and the Mysterious Ways of Data Interpretation?


Onyx Embolization for Occlusion of the Proximal Internal Iliac Artery During EVAR in Patients with Unsuitable Landing Zones in the Common Iliac Artery

Abstract

Background

Twenty percent of the patients with AAA have an aneurysm involving the common iliac arteries. Large common iliac diameter can be treated with an iliac branched device or extension of the stent graft to the external iliac artery with occlusion of the ipsilateral internal iliac artery (IIA) to prevent type 2 endoleaks. This study describes and evaluates a embolization technique using Onyx in conjunction with EVAR in aneurysms with poor landing zones in the common iliac arteries.

Methods

Patients with Onyx IIA embolization during EVAR, identified from the hospital operating code database, constitute the study population. Onyx embolization was performed by injection at the IIA origin. Peri- and postoperative complications were collected from the medical records. Thin-sliced CT scan was performed 1 month and 1 year after the procedure.

Results

Thirty-six patients with complex iliac anatomy and insufficient landing zones (without sealing possibility for standard stent grafts) were identified out of 243 consecutive EVAR treatments during a 13-year period. In seventeen patients (7%), the IIA was embolized with Onyx. Technical success was obtained in all 17 patients, without adverse event or procedural complication. No complication related to the embolization procedure was noted during follow-up.

Conclusions

During EVAR treatment of patients with aneurysm involving the common iliac artery, Onyx embolization of IIA is a feasible option without need of selective catheterization of the IIA orifice, potentially preserving important branches of the IIA and simplifying emergency procedures.



Transarterial Chemoembolisation of Colorectal Liver Metastases with Irinotecan-Loaded Beads: A Bi-institutional Analysis of 125 Treatments in 53 Patients

Abstract

Purpose

To retrospectively review outcomes in patients treated for colorectal liver metastases with DEBIRI.

Materials and Methods

A retrospective analysis of patients with CRLM treated with DEBIRI was performed between 2008 and 2017 between two tertiary centres. Outcome parameters were overall survival and hepatic progression-free survival, as well as safety. Subgroup analyses were performed to assess the impact on outcomes of hepatic tumour burden at time of treatment, the presence of extrahepatic disease, prior systemic chemotherapy and the prior administration of systemic irinotecan-containing chemotherapy.

Results

Fifty-three patients received 125 treatments with DEBIRI over the study period. Median age of patients was 71 (range 41–88). Patients previously received a median of 1 line of chemotherapy (range 1–5). Median number of DEBIRI treatments was 2 (range 1–6). The median survival from first treatment was 14.5 months (range 1–107). Median hepatic progression-free survival was 5 months (0–86.5 months). The presence of extrahepatic disease (seen in 45% of patients) correlated with lower OS. Prolonged OS was seen in patients who received previous ablation and systemic chemotherapy. Technical success rate was found to be 99%. Post-procedural complication rate was 6%.

Conclusion

Our findings add to the growing body of literature to support the safety profile of DEBIRI in the treatment of CRLM. Further studies will be necessary to help establish the optimum berth of DEBIRI in the treatment algorithm for colorectal liver metastases.



Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

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