Penicillin and cephalosporin cross-reactivity: role of side chain and synthetic cefadroxil epitopes

pa.ythelady61 shared this article with you from Inoreader Penicillin and cephalosporin cross-reactivity: role of side chain and synthetic cefadroxil epitopes Via Allergy Analysis of cross-reactivity is necessary for prescribing safe cephalosporins for penicillin allergic patients. Amoxicillin (AX) is the betalactam most often involved in immediate hypersensitivity reactions (I... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Leukotriene D4 Paradoxically Limits LTC4 Driven Platelet Activation and Lung Immunopathology

pa.ythelady61 shared this article with you from Inoreader Leukotriene D4 Paradoxically Limits LTC4 Driven Platelet Activation and Lung Immunopathology Via Journal of Allergy and Clinical Immunology Capsule summary. LTD4, the conversion product of LTC4, potently elicits bronchoconstriction, but blocks LTC4-induced platelet activation, pulmonary eosinophilia, and IL-33 induction through CysLT2R. Conversion to LTD4 may limit the severity of allergic inflammation potentiated by LTC4 production. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Influence of Surface Electromyography Visual and Clinician Verbal Feedback on Swallow Effort Ratio at Different Bolus Volumes in a Healthy Population

pa.ythelady61 shared this article with you from Inoreader The Influence of Surface Electromyography Visual and Clinician Verbal Feedback on Swallow Effort Ratio at Different Bolus Volumes in a Healthy Population Via Folia Phoniatrica et Logopaedica Background/Aims: The effortful swallow is a common treatment intervention requiring increased intensity to facilitate adaptations and modify swallow kinematics. The type of feedback and bolus volume provided may influence the intensity of the effortful swallow. To determine the increased effortful swallow intensity, a clinician can collect the peak amplitude of an effortful swallow and a typical swallow and compute a "swallow effort ratio" (SER). Dividing the effortful swall ow surface electromyography (sEMG) peak amplitude by the typical swallow sEMG peak amplitude derives the SER. A higher SER suggests increased intensity. An increase in the SER may have clinical relevance in swallowing therapy as a threshold of intensity is required to elicit neuroplastic change. The purpose of this investigation was to determine whether sEMG visual and clinician verbal feedback increases the SER. Additionally, the investigation examined whether the SER is influenced by different liquid bolus volumes. Methods: Eighty-two nondysphagic, healthy adults were assigned at random to 2 groups. One group received no feedback, and the other received verbal and visual feedback while performing typical and effortful swallows at 3 liquid volumes. Results: An analysis of covariance compared the typical and effortful peak swallow amplitudes among 3 volumes in the 2 feedback groups. There was a significant effect on the peak amplitude values by feedback g roup F(2, 79) = 22.82, p #x3c; 0.001. There were no differences in peak amplitude by volume regardless of feedback F(2, 78) = 0.413, p = 0.663. Conclusion: It appears that sEMG visual and clinician verbal feedback increases the SER, which may be a surrogate for intensity. An increased SER may have a positive effect on swallow intervention as intensity is known to influence outcomes of exercise and elicit neuroplastic change. Folia Phoniatr Logop View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Perdida de peso involuntaria: causas

pa.ythelady61 shared this article with you from Inoreader Perdida de peso involuntaria: causas Via Cuida tu tiroides La pérdida de peso involuntaria y que no se explica por un cambio de hábitos es una preocupación que puede tener causas diferentes. Entre ellas están las alteraciones en el funcionamiento de la glándula tiroides.  La pérdida de peso involuntaria puede deberse a causas diversas: Efectos secundarios de algunos medicamentos (algunos de los que se emplean para tratar condiciones de la tiroides) Alteraciones de la salud mental o el estado de ánimo Alcoholismo Anorexia nerviosa Dificultad para tragar (un síntoma de diferentes enfermedades) Alteraciones de la salud bucodental Alteraciones cognitivas Problemas intestinales Cáncer  Hipertiroidismo, hipotiroidismo, hiperparatiroidismo, hipoadrenalismo Pérdida de peso y problemas de tiroides Los científicos han comprobado hace tiempo que la relación entre las enfermedades de la tiroides, el peso corporal y el metabolismo es estrecha, pero no necesariamente sencilla. Aunque las hormonas de la glándula tiroides son importantísimas para el peso corporal, no son ni mucho menos el único elemento que determina una posible pérdida de peso involuntaria. Hay otras hormonas, proteínas y procesos del organismo que pueden explicar por qué una persona pierde peso. Las hormonas tiroideas regulan el metabolismo. Si la medida del metabolismo se obtiene en reposo, el resultado se denomina tasa metabólica basal (TMB, o BMR por sus siglas en inglés).  Los expertos en endocrinología han investigado la relación entre TMB y han llegado a las siguientes conclusiones: La TMB en valores bajos está asociada con niveles bajos de hormonas tiroideas en el organismo La TMB en valores altos está asociada con niveles elevados de hormonas tiroideas (hipertiroidismo), una de las posibles causas de pérdida de peso involuntaria La TMB ya casi no se emplea debido a la complejidad de la prueba y a que hay más factores que causan pérdida de peso, pero su relación con la tiroides está establecida.  En cuanto a la relación entre TMB y condiciones de la tiroides, se ha documentado que los valores elevados en esta prueba en personas con hipertiroidismo llevan asociados en muchas ocasiones pérdida de peso involuntaria. Además, la pérdida de peso es mayor si el hipertiroidismo es severo. Por ejemplo, si la tiroides está extremadamente hiperactiva -produciendo hormonas en cantidades sustancialmente excesivas- la TMB del paciente se incrementa. Eso hace que el cuerpo necesite más calorías para mantener su actividad normal. Es una de las causas de pérdida de peso relacionada con la actividad de la tiroides. Puesto que el hipertiroidismo es un estado alterado del organismo, puede predecirse que la pérdida de peso se corregirá cuando la tiroides recupere la normalidad. De todas formas, los especialistas suelen recordar que los factores que controlan nuestro apetito, metabolismo y actividad son extremadamente complejos. Las hormonas de la glándula tiroides son únicamente uno de esos factores. Si sospechas que puedes padecer alguna enfermedad de la glándula tiroides debes hablar con tu médico. En el siguiente test te damos algunas pistas.   FUENTES American Thyroid Association. Thyroid and Weight FAQs. Torlinska B et al 2019 Patients treated for hyperthyroidism are at increased risk of becoming obese: findings from a large prospective secondary care cohort. Thyroid 29:1380–1389. PMID: 31375059. Gang L, et al. Abstract 11438: Thyroid Hormones and Changes in Body Weight and Metabolic Parameters in Response to Weight-Loss Diets: The POUNDS LOST Trial. Circulation. 2016;134:A11438 La entrada Perdida de peso involuntaria: causas se publicó primero en Cuida tu tiroides. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Rhinologic disease and its impact on sleep: a systematic review

pa.ythelady61 shared this article with you from Inoreader Rhinologic disease and its impact on sleep: a systematic review Via International Forum of Allergy & Rhinology Background Rhinologic disease can be responsible for systemic symptoms affecting mood, cognition, and sleep. It is unclear whether sleep disturbance in specific rhinologic disorders (chronic rhinosinusitis [CRS], rhinitis, and nasal septal deviation [NSD]) is an obstructive phenomenon or due to other mechanisms. In this review we examine the impact of CRS, rhinitis, and NSD on objective and subjective sleep outcome metrics and draw comparisons to normal controls and patients with known obstructive sleep apnea (OSA). Methods A systematic review of 4 databases (PubMed, Scopus, Cochrane Library, and Web of Science) was performed. Studies reporting on objective (apnea‐hypopnea index [AHI], respiratory disturbance index [RDI], oxygen nadir) and subjective (Epworth Sleepiness Scale [EpSS], Pittsburgh Sleep Quality Index [PSQI], Fatigue Severity Scale [FSS]) sleep parameters and disease‐specific patient‐reported outcome measures (PROMs; 22‐item Sino‐Nasal Outcome Test [SNOT‐22], Rhinoconjunctivitis Quality of Life Questionnaire [RQLQ], Nasal Obstruction Symptom Evaluation [NOSE]) were included. Results The database search yielded 1414 unique articles, of which 103 were included for analysis. Baseline PROMs were at the high end of normal to abnormal for all 3 conditions: EpSS: CRS (9.8 ± 4.0), rhinitis (9.7 ± 4.3), and NSD (8.9 ± 4.6); and PSQI: CRS (11.0 ± 4.5), rhinitis (6.1 ± 3.7), and NSD (8.6 ± 3.5). Objective measures demonstrated a mild to moderate OSA in the studied diseases: AHI: CRS (10.4 ± 11.5), rhinitis (8.6 ± 8.8), and NSD (13.0 ± 6.9). There were significant differences when compared with reported norms in all measured outcomes (p < 0.001). Conclusion Sleep quality is impacted by rhinologic (CRS, rhinitis, NSD) disease. There is likely a mild obstructive component contributing to poor sleep, but other contributing factors may be involved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Risk factors for subsequent recurrence after surgical treatment of recurrent pleomorphic adenoma of the parotid gland

pa.ythelady61 shared this article with you from Inoreader Risk factors for subsequent recurrence after surgical treatment of recurrent pleomorphic adenoma of the parotid gland Via Head & Neck Abstract Background Recurrent pleomorphic adenoma (PA) can be a lifelong disease, and rates of subsequent recurrence are high. Methods Patients between 2000 and 2015 were identified. Primary outcome was subsequent recurrence after surgical salvage. Results Twenty‐seven of 84 patients developed a subsequent recurrence. Risk factors for subsequent recurrence included a higher number of previous recurrences (P < .01), worse preoperative facial nerve function (P < .01), and deep parotid lesion(s) (P < .01). Interval since last surgery was protective (P < .01), specifically >10 years since last surgery (P < .01). For patients with a >10‐year interval since their last surgery, the subsequent recurrence‐free rate at 10 years follow‐up was 80.2% vs 31.8%. Conclusions For patients presenting with a >10‐year interval since their last surgery, subsequent recurrence rates are low, which may allow for as needed surveillance recommendations. For patients presenting with recurrent PA and ≤10 years since their last surgery, a closer surveillance is warranted. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Smart needle to diagnose metastatic lymph node using electrical impedance spectroscopy

pa.ythelady61 shared this article with you from Inoreader Smart needle to diagnose metastatic lymph node using electrical impedance spectroscopy Via Auris Nasus Larynx The cause of cervical lymphadenopathy varies from inflammation to malignancy. Accurate and prompt diagnosis is crucial as delayed detection of malignant lymph node can lead to a worse prognosis. To improve the diagnostic accuracy of metastatic lymph node, electrical spectroscopy was employed to study human normal and metastatic lymph nodes using a hypodermic needle with fine interdigitated electrodes on its tip (EoN). View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.