Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Δευτέρα 8 Φεβρουαρίου 2021

Differentiated Thyroid Cancer Patients with Increased Thyroglobulin and Negative Radioiodine Scintigraphy Have Similar Long-Term Survival Whether or Not 18F-FDG–PET Imaging Is Used in Long-Term Monitoring

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Clinical Thyroidology, Volume 33, Issue 2, Page 92-95, February 2021.
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The Incidence of Overt Hyperthyroidism After Exposure to Iodinated Radiologic Contrast Media Is Extremely Low

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Clinical Thyroidology, Volume 33, Issue 2, Page 77-79, February 2021.
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What Do Hürthle Cells Mean in Thyroid Nodule Aspirates?

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Clinical Thyroidology, Volume 33, Issue 2, Page 83-86, February 2021.
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Effect of a Single Injection of Basic Fibroblast Growth Factor into the Vocal Folds: A 36-Month Clinical Study

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A single injection of basic fibroblast growth factor (bFGF) into the vocal folds of patients with glottal insufficiency has been shown to be effective for a few years. However, the long-term therapeutic effect of a single injection of bFGF into the vocal folds has yet to be demonstrated. In this study, the therapeutic effect of a single injection of bFGF into the vocal folds was investigated over several years by monitoring patients for 36 months following this treatment.
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Sensitivity to Pulse Phase Duration as a Marker of Neural Health Across Cochlear Implant Recipients and Electrodes

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Abstract

In cochlear implants, loudness has been shown to grow more slowly with increasing pulse phase duration (PPD) than with pulse amplitude (PA), possibly due to "leaky" charge integration. This leakiness has been recently quantified in terms of "charge integration efficiency," defined as the log difference between the PPD dynamic range and PA dynamic range (both expressed in charge units), relative to a common threshold anchor. Such leakiness may differ across electrodes and/or test ears, and may reflect underlying neural health. In this study, we examined the across-site variation of charge integration in recipients of Cochlear© devices. PPD and PA dynamic ranges were measured relative to two threshold anchors with either a 25- or 50-microsecond PPD. Strength-duration functions, previously shown to relate to survival of spiral ganglion cells and peripheral processes, were compared to charge integration efficiency on selected electrodes. Results showed no si gnificant or systematic relationship between the across-site variation in charge integration efficiency and electrode position or threshold levels. Charge integration efficiency was poorer with the 50-μs threshold anchor, suggesting that greater leakiness was associated with larger PPD dynamic ranges. Poorer and more variable charge integration efficiency across electrodes was associated with longer duration of any hearing loss, consistent with the idea that poor integration is related to neural degeneration. More variable integration efficiency was also associated with poorer speech recognition performance across test ears. The slopes of the strength-duration functions at maximum acceptable loudness were significantly correlated with charge integration efficiency. However, the strength-duration slopes were not predictive of duration of any hearing loss or speech recognition performance in our participants. As such, charge integration efficiency may be a better candidate to measure leakiness in neural populations across the electrode array, as well as the general health of the auditory nerve in human cochlear implant recipients.

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Thyrotropin Receptor-Specific Lymphocytes in Adenovirus-TSHR-Immunized Native and Human Leukocyte Antigen-DR3-Transgenic Mice and in Graves' Disease Patient Blood

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Thyroid, Ahead of Print.
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Κυριακή 7 Φεβρουαρίου 2021

Role of Blood Investigations in Idiopathic Unilateral Sensorineural Hearing Loss

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Abstract

Majority of unilateral sensorineural hearing loss are idiopathic. Hence, outcome depends on factors which are associated with nature of disease and its treatment. These can be sudden or progressive. Various studies are done to evaluate the association in sudden variety, however causality still lacks evidence. There are limited studies regarding progressive variety and its outcome. A prospective study of 40 patients with idiopathic unilateral SNHL was carried out which attempts at identifying factors associated with either disease severity or its prognosis. A significant association was seen between distribution of random blood sugar and post treatment improvement in patients with sudden USNHL (p = 0.045). No significant association was seen with other blood parameters to treatment outcome in sudden SNHL, and severity of progressive SNHL to any blood parameters. Elevated blood sugar may affect a negative effect on treatment outcome in unilateral ISSNH L. There is scarcity of evidence in scientific literature related to "Unilateral Idiopathic Progressive Sensorineural Hearing Loss" for any association/correlation with nature of disease.

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