Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

Αρχειοθήκη ιστολογίου

! # Ola via Alexandros G.Sfakianakis on Inoreader

Η λίστα ιστολογίων μου

Τρίτη 9 Μαρτίου 2021

The Axillary Flap/Trans‐agger Approach as a Supero‐lateral Conduit to the Effective Frontal Recess for Marsupialization of Fronto‐ethmoid Mucocele

xlomafota13 shared this article with you from Inoreader

Abstract

Frontal‐orbital‐ethmoid mucocele (henceforth, "the mucocele") is often slow‐growing and insidious, needing watchful observation. But when symptomatic, complete endoscopic marsupialization is the intervention of choice.2,3 The mucocele's free wall, generally seen occupying the frontal recess (FR) in the ethmoid infundibulum/third pass roof, has a convenient transmeatal endoscopic access. However, much of the dependent surface remains hidden supero‐lateral within the bony lateral nasal wall behind the agger nasi, and further posterior into the migrated, intercommunicating ethmoid airspaces along the skull‐base. Failure to address the mucocele completely by marsupializing only its visible, infero‐medial aspect through the transmeatal route alone results in limited sinus drainage, and subsequent recurrence. Here, understanding the concept of "effective FR" (eFR) is essential. The eFR is formed by considering the FR and the migrated ethmoid air� �cells as functional patho‐anatomic compartments for an expanding, space‐occupying lesion like mucocele. The surgical technique described here is based on eFR compartmentalization and the mucocele's preferential path of progress. This ensures complete marsupialization, a wider Draf IIa ventilation/drainage basin, and a safe, co‐planar, superiorly‐placed endoscopic vision ("endo‐vision") across the mucocele and the vascular structures of skull‐base.

View on the web

A novel method to objectively assess robotic assistance in laparoscopic colorectal surgery

xlomafota13 shared this article with you from Inoreader

Abstract

Objective

An objective assessment of robotic assistance in colorectal surgery.

Background

There is a lack of objective evidence behind the claims of superior optics and improved ergonomics with robotics. This study introduces a novel method of assessing how robotics facilitates colorectal surgery.

Methods

Operative videos of laparoscopic and robotic surgeries were reviewed. Two components were evaluated—scope‐holder performance was assessed using a transparent overlay to partition the video image and provide lines for measurement; assistant instrument performance was measured using a separate matrix of movement episodes and time.

Results

The views achieved in robotic surgery were superior and less dependent on the assistant. The degree of assistance provided by the robotic system was more than that of the human assistant.

Conclusions

The use of robotics allows a trained operator to project his skills threefold—as a scope holder, operator and assistant—providing superior visualization and dynamic assistance throughout surgery.

View on the web

The Feasibility of Gastroesophageal Manometry for Continuously Evaluating the Degree of Expiratory Effort During Successful Crescendo Phonation

xlomafota13 shared this article with you from Inoreader
Via Voice

1-s2.0-S0892199721X00021-cov150h.gif

Publication date: Available online 8 March 2021

Source: Journal of Voice

Author(s): Masanori Umatani, Makoto Ogawa, Kiyohito Hosokawa, Chieri Kato, Eri Okajima, Toshihiko Iwahashi, Hidenori Inohara

View on the web

Vocal Fold Steroid Injection for Benign Vocal Lesions in Professional Voice Users

xlomafota13 shared this article with you from Inoreader
Via Voice

1-s2.0-S0892199721X00021-cov150h.gif

Publication date: Available online 8 March 2021

Source: Journal of Voice

Author(s): Chien-Hao Wu, Wu-Chia Lo, Li-Jen Liao, Yi-Chia Kao, Chi-Te Wang

View on the web

Glandular Stem Cells in the Skin during Development, Homeostasis, Wound Repair and Regeneration

xlomafota13 shared this article with you from Inoreader

Abstract

Glands in the skin are essential for various physiological functions involving exocrine secretion. Like other tissues and organs, they possess the ability to repair injury and self‐renew during homeostasis. Progenitor cells in glands are mostly unipotent but include some multipotent stem cells that function when extensive remodeling or regeneration is required. In this review, using two glandular models in skin, mouse sweat gland and mammary gland, we discuss lineage restriction that develops during glandular morphogenesis, as well as the mechanisms regulating cell fate and plasticity during wound repair and regeneration. Understanding the intrinsic and extrinsic factors that control the behaviors of glandular stem cell and maintain glandular functions will provide insight into future prospects for glandular regeneration.

View on the web

NKG2D and its ligands as cytotoxic factors in cutaneous lupus erythematosus

xlomafota13 shared this article with you from Inoreader

Abstract

Cutaneous lupus erythematosus (CLE) is an autoimmune skin disorder that is characterized by an anti‐epidermal lymphocytic infiltrate invading the dermo‐epidermal junction, causing an interface dermatitis (ID). Pathogenesis of CLE has been linked to activation of innate immunity. NKG2D is an innate immune receptor on NK cells and distinct T‐cell populations. The NKG2D ligands MHC class I polypeptide‐related sequence A and B (MICA, MICB) have been associated to CLE susceptibility. Our gene microarray analyses of chronic discoid lupus erythematosus (CDLE) skin lesions, separated in epidermal, junctional and dermal skin areas via laser microdissection, revealed a high expression of NKG2D in the lymphocytic infiltrate and led us to further investigate the role of NKG2D in CLE. Pathway analyses showed a strong "interferon (IFN) signature" and vast activation of innate immune response pathways (TLR, RIG‐I, cytosolic DNA sensing, JAK/STAT) in CDLE, that expressed the high NK G2D signal. Immunohistochemistry (IHC) confirmed the presence of NKG2D and its ligand MICB in CDLE and subacute cutaneous lupus erythematosus (SCLE) lesions. Finally, HaCaT cells were stimulated with nucleic acids and extracted RNA was sequenced with Illumina HiSeq and showed that stressed keratinocytes express typical NKG2D ligands MICA/B and ULBP2. This study provides first evidence that NKG2D is present in CDLE and SCLE skin lesions and could be relevant for cytotoxicity in IFN‐driven skin lesions with upregulated innate immune response pathways present in CLE. It could furthermore play a role in CLE inflammation promoted by keratinocytes under cell stress.

View on the web

Exclusive Two Handed Endoscopic Cartilage Type 3 Tympanoplasty with Endoscope Holders

xlomafota13 shared this article with you from Inoreader

12070.jpg

Abstract

In present world of contemporary techniques of microscopic ear surgery and single handed endoscopic ear surgery, we propose the technique of two handed endoscopic tympanoplasty using endoscope holders. The aim of the study  is to evaluate the functional and anatomical results of our technique of endoscopic type 3 cartilage tympanoplasty using endoscope holder. It is a Retrospective Non Randomized Clinical Study. A total of 67 endoscope holder assisted exclusively two handed endoscopic type 3 cartilage tympanoplasties performed from December 2014 to March 2017 with our technique were included in the study. Patients with pars tensa retractions and perforations with absent incus were included in the study. Those with cholesteatoma were excluded from the study. Full thickness tragal cartilage disc of 3 × 3 mm dimensions with a circular slot of 1 mm to fit onto the head of the stapes was used for reconstruction. Tympanic membrane reconstr uction was done along with attic reconstruction, using sliced tragal cartilage of 0.5 mm thickness. Patients were assessed at 6, 12 and 24 months for graft status. In early follow up period ranging from 24 to 52 months, the graft take up was seen in 64 ears with three perforations giving a success rate of 95.52%. The pre-operative air-bone gap was 42.6 ± 3.26 dB and the post-operative air-bone gap at 6 months, 1 and 2 years was 18.36 ± 3.46 dB, 19.42 ± 4.32 dB and 19.53 ± 4.33 dB respectively. The study reports good air-bone closure to 20 dB postoperatively following type 3 endoscopic tympanoplasty using endoscope holder. Slotted cartilage graft is definitely an excellent option for ossiculoplasty in cases of absent incus providing a stable assembly.

Level of evidence: Level 4.

View on the web

Αρχειοθήκη ιστολογίου