Drug-drug interactions of tyrosine kinase inhibitors in treatment of non-small-cell lung carcinoma

xlomafota13 shared this article with you from Inoreader Drug-drug interactions of tyrosine kinase inhibitors in treatment of non-small-cell lung carcinoma Via Association française pour l'étude du cancer Bull Cancer. 2022 Jan 29:S0007-4551(22)00010-8. doi: 10.1016/j.bulcan.2021.11.019. Online ahead of print. ABSTRACT The development of tyrosine kinase inhibitors has revolutionized the treatment strategy in patients with non-small cell lung cancer with activating EGFR mutations, ALK or ROS-1 gene rearrangements. The Food and Drug Administration and European Medicines Agency have approved several inhibitors for the treatment of non-small cell lung cancer : five tyrosine kinase inhibitors targeting EGFR (erlotinib, gefitinib, afatinib, osimertinib and dacomitinib) and six tyrosine kinase inhibitors targeting ALK (crizotinib, céritinib, alectinib, brigatinib, lorlatinib and entrectinib). Interestingly, these tyrosine kinase inhibitor treatments are administered orally. While this route of administration improves the treatment flexibility and provides a comfortable and preferable option for patients, it also increases the risk of drug-drug interactions. The latter may result in changes in pharmacokinetics or pharmacodynamics of the tyrosine kinase inhibitors or their concomitant treatments, with subsequent risks of increasing their toxicity and/or reducing their effectiveness. This review provides an overview of drug-drug interactions with tyrosine kinase inhibitors targeting EGFR and ALK, as well as practical recommendations to guide oncologists and clinical pharmacists in the process of managing drug-drug interactions during the treatment of non-small cell lung cancer with tyrosine kinase inhibitors. PMID:35105467 | DOI:10.1016/j.bulcan.2021.11.019 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effects of transfusion of stored blood in patients with transfusion-dependent thalassemia

xlomafota13 shared this article with you from Inoreader Effects of transfusion of stored blood in patients with transfusion-dependent thalassemia Via American Journal of Blood Research Am J Blood Res. 2021 Dec 15;11(6):592-599. eCollection 2021. ABSTRACT OBJECTIVES: The aim of this study was to investigate the hematological and biochemical effects of stored blood transfusion on patients with transfusion-dependent thalassemia (TDT). METHODS: In this quasi-experimental study, 20-patients with TDT were enrolled. Each participant received on first visit, freshly collected red cell concentrate (RCC) (<2-days storage) and 15-days later on second visit, 7-days stored blood. Blood samples were obtained immediately before and 24-hours after each transfusion. Differences in the Complete blood counts, bilirubin, LDH, C-Reactive protein, ferritin, and iron levels in the pre- and post-transfusion samples were compared between the first and second transfusion. RESULTS: Fresh blood transfusion resulted in a higher (but non-significant) increase in hemoglobin and other red cell parameters. Notably, a significant incre ase in white cell counts (WCC) was seen in 7-days stored blood vs fresh blood (1.82×109/l vs 1.01×109/l, P=0.002). No statistically significant difference was found in LDH, direct and indirect bilirubin, creatinine, blood glucose, serum uric acid, serum ferritin, and serum Iron levels. There was a statistically significant rise in C-reactive protein levels in stored (6.43±7.46 mg/dl) versus fresh RCC (1.89±2.38 mg/dl), p-value =0.012. CONCLUSIONS: We show that in patients with chronic TDT, an increase in inflammation-associated markers (WCC and CRP) is observed. Further studies to assess the extent and duration of this increase are needed. PMID:35103113 | PMC:PMC8784645 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An analysis of hematological, coagulation and biochemical markers in COVID-19 disease and their association with clinical severity and mortality: an Indian outlook

xlomafota13 shared this article with you from Inoreader An analysis of hematological, coagulation and biochemical markers in COVID-19 disease and their association with clinical severity and mortality: an Indian outlook Via American Journal of Blood Research Am J Blood Res. 2021 Dec 15;11(6):580-591. eCollection 2021. ABSTRACT BACKGROUND: The "cytokine storm" (CS) in COVID-19 leads to the worst stage of illness which can be controlled only with timely intervention. There is an urgent need to identify laboratory markers of disease progression for optimum allocation of resources in developing countries like India. METHODS: A cross-sectional study was conducted on 100 COVID-19 positive patients over two months. The cases were sub-classified based on disease severity into mild to moderate (n=61), severe (n=26) and very severe (n=13) and into survivors (n=85) and non-survivors (n=15) based on survivor status. These patients were tested for hematological parameters (total blood lymphocyte counts, NLR, PLR, platelet indices etc.), coagulation markers (D-dimer, fibrin degradation products (FDP), fibrinogen etc.) and biochemical markers (LDH, ferritin, IL-6, procalcitonin, hs-CRP). RESU LTS: Statistically significant differences were observed in hematological variables (ANC, NLR and ESR), coagulation parameters (D-dimer, FDP, fibrinogen and thrombin time) and biochemical markers (LDH, ferritin, IL-6, procalcitonin and hs-CRP) with regard to subcategories based of disease severity as well as survivor status. There was strong correlation between NLR, D-dimer, IL-6, procalcitonin and ferritin. IL-6 emerged as the single best marker of disease severity (AUC: 0.997, P=0.00), however procalcitonin, LDH, D-dimer, FDP and NLR could also predict severe disease with a good sensitivity and specificity. CONCLUSION: To conclude, study demonstrates a plethora of biomarkers which could be utilized to accurately identify the hyperinflammation and tissue damage reminiscent of cytokine storm in COVID-19 patients so that timely, safe, and effective therapies can be administered to prevent progression and potentially reduce mortality. PMID:35103112 | PMC:PMC8784646 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A review of neoplasms with MITF/MiT family translocations

xlomafota13 shared this article with you from Inoreader A review of neoplasms with MITF/MiT family translocations Via Cellular and Molecular Biology Histol Histopathol. 2022 Feb 2:18426. doi: 10.14670/HH-18-426. Online ahead of print. ABSTRACT Microphthalmia-associated transcription factor (MITF/MiT) family is a group of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors including TFE3 (TFEA), TFEB, TFEC and MITF. The first renal neoplasms involving MITF family translocation were renal cell carcinomas with chromosome translocations involving ASPL-TFE3/t(X;17)(p11.23;q25) or MALAT1-TFEB/t(6;11)(p21.1;q12), and now it is known as MiT family translocation RCC in 2016 WHO classification. Translocations involving MITF family genes also are found in other tumor types, such as perivascular epithelioid cell neoplasm (PEComa), Alveolar soft part sarcoma (ASPS), epithelioid hemangioendothelioma, ossifying fibromyxoid tumor (OFMT), and clear cell tumor with melanocytic differentiation and ACTIN-MITF translocation. In this review, we summarize the features of different types of neoplasms with MITF family translocations. PMID:35107169 | DOI:10.14670/HH-18-426 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Adenoid stones, an unknown culprit in pediatric throat pain

xlomafota13 shared this article with you from Inoreader Adenoid stones, an unknown culprit in pediatric throat pain Via ear nose throat Ear Nose Throat J. 2022 Feb 2:1455613221074139. doi: 10.1177/01455613221074139. Online ahead of print. ABSTRACT We present a case of a 12-year-old male who presented with complaints of nasal congestion, intermittent throat pain, and odynophagia. He was taken to the operating room for inferior turbinate reduction and adenoidectomy and found to have stones within adenoid crypts. Adenoidectomy resulted in resolution of the patient's throat pain and pain with swallowing. Not pre viously described in the literature, adenoid stones may represent an unrecognized etiology of odynophagia and throat pain in the pediatric population. Adenoidectomy should be considered for patients symptomatic from adenoid stones. PMID:35107383 | DOI:10.1177/01455613221074139 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sonographische Diagnostik tonsillärer Abszesse: Eigene Erfahrungen und eine systematische Übersicht

xlomafota13 shared this article with you from Inoreader Sonographische Diagnostik tonsillärer Abszesse: Eigene Erfahrungen und eine systematische Übersicht Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1744-6305 Hintergrund Die transkutane Sonografie ist seit einigen Jahrzehnten ein fester Bestandteil der bildgebenden Diagnostik im Kopf-Hals-Bereich. Insbesondere in der Darstellung von Abszessen der Fossa tonsillaris ist die Sonografie eine schnelle, sichere und kostengünstige diagnostische Methode. Diese Arbeit soll einen Überblick über die derzeit publizierten Studien in Bezug auf die diagnostische Wertigkeit geben. Material und Methoden Systematische Literaturrecherche in folgenden Online-Datenbanken: PubMed und MEDLINE nach den Suchbegriffen transcutaneous ultrasound, tonsillar abscess, peritonsillar abscess, intratonsillar abscess, peritonsillar cellulitis und parapharyngeal abscess. Bewertung der wissenschaftlichen Relevanz der Arbeiten nach festgelegten Kriterien. Ergebnisse Die Publikationen wurden in Bezug auf die klinische Anwendung, die klinische Befunderhebung und die diagnostische Genauigkeit analysiert. Die Sensitivität und Spezifität werden je nach Studie und Patientenkollektiv zwischen 67 % und 100 % bzw. 50 % und 93 % angegeben. Schlussfolgerungen In Zusammenschau der aktuell publizierten Ergebnisse verspricht die transkutane Sonografie ein großes Potenzial, die Diagnostik des Peritonsillarabszesses zu verbessern, und ermöglicht eine gute Abgrenzbarkeit zur peritonsillären Zellulitis. Dies ist für das klinische Management von Patienten mit Abszessverdacht von entscheidender Bedeutung. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |& nbsp; Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Markerless registration approach using dynamic touchable region model

xlomafota13 shared this article with you from Inoreader Markerless registration approach using dynamic touchable region model Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background Markerless registration is required for image-guided surgery; it has limited accuracy due to the ambiguity of the correspondence point set. In this study, we proposed a registration framework to improve registration accuracy for markerless registration using a dynamic touchable region model (DTRM). Methods The DTRM is defined using the geometric characteristics of the surface around the fiducial area using Intrinsic Shape Signature (ISS) keypoints. The new registration procedure, which combines the DTRM with iterative closest point-based registration (ICDTP) was implemented and verified with phantom experiments for a single-user and multi-user study. Results The ICDTP registration framework provides improved performance over the paired-point registration for surgeries, where it is inappropriate to construct the corresponding positions with adhesive fiducial markers. Conclusion The proposed method can be an alternative approach for image-guided surgery in operations for which it is not appropriate to set up markers for registration. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.