Anti-DFS70 antibodies in healthy schoolchildren: A follow-up analysis

Publication date: Available online 4 January 2017
Source:Autoimmunity Reviews
Author(s): Francesca Sperotto, Mara Seguso, Nicoletta Gallo, Mario Plebani, Francesco Zulian




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Anti-DFS70 antibodies in healthy schoolchildren: A follow-up analysis

Publication date: Available online 4 January 2017
Source:Autoimmunity Reviews
Author(s): Francesca Sperotto, Mara Seguso, Nicoletta Gallo, Mario Plebani, Francesco Zulian




http://ift.tt/2j6yzCE

RNA in situ hybridization characterization of non-enzymatic derived bovine intervertebral disc cell lineages suggests progenitor cell potential

Publication date: Available online 4 January 2017
Source:Acta Histochemica
Author(s): Petra Kraus, Rachel Yerden, Victoria Kocsis, Thomas Lufkin
Degeneration of the intervertebral disc (IVD) is a meritorious target for therapeutic cell based regenerative medicine approaches, however, controversy over what defines the precise identity of mature IVD cells and lack of single cell based quality control measures is of concern. Bos taurus and human IVDs are histologically more similar than is Mus musculus. The mature bovine IVD is well suited as model system for technology development to be translated into therapeutic cell based regenerative medicine applications. We present a reproducible non-enzymatic protocol to isolate cell progenitor populations of three distinct areas of the mature bovine IVD. Bovine specific RNA probes were validated in situ and employed to assess fate changes, heterogeneity, stem cell characteristics and differentiation potential of the cultures. Quality control measures with single cell resolution like RNA in situ hybridization to assess culture heterogeneity (PISH) followed by optimization of culture conditions could be translated to human IVD cell culture to increase the safety of cell based regenerative medicine.



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Management of the neck in early oral cancers: Is the verdict out?

Vishal U. S. Rao, Prashant H Patil, BV Rajaram

Journal of Cancer Research and Therapeutics 2016 12(3):1114-1116

The management of patients with the clinically negative neck (N0) in early oral cancers awaits a clear mandate despite growing evidence favoring elective neck dissection. Having a general policy of operating all N0 neck may indeed increase the number of unnecessary neck dissection in the true pathological N0 necks, a more commonly encountered scenario. This controversy needs to be looked beyond statistical evidence to address a larger question to "does the neck truly harbor disease," thus, refining the early age old debate. This article highlights the feasibility of wait and watch policy, while elaborating a stringent algorithm to judiciously select patients in whom the neck may be safely observed.

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Immunoplasticity in cutaneous melanoma: beyond pure morphology

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Radioiodine as an adjuvant therapy and its role in follow-up of differentiated thyroid cancer

S Padma, P Shanmuga Sundaram

Journal of Cancer Research and Therapeutics 2016 12(3):1109-1113

Papillary and follicular cancers of thyroid are the most common varieties of differentiated thyroid cancers exhibiting excellent long-term prognosis when carefully managed. Being a slow-growing malignancy, guidelines exist on the staging, preoperative risk stratification, and management of these cancers to increase the overall survival of these patients. Radioactive iodine has a central role in differentiated thyroid malignancies. It has the same physical properties as stable iodine, thus both normal and malignant thyrocytes cannot differentiate radioactive from stable iodine. Differentiated thyroid carcinoma (DTC) cells concentrate cytocidal amounts of Iodine -131 (131 I) by trapping (the function of the sodium iodine symporter, or NIS) and organifying the iodide ion to produce levothyroxine and triiodothyronine. We shall discuss the role of radioiodine in the management and followup of DTC patients.

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Erratum: Application of intelligent algorithm in the optimization of novel protein regulatory pathway: Mechanism of action of gastric carcinoma protein p42.3

Journal of Cancer Research and Therapeutics 2016 12(3):1212-1212



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