Provider Training in Increasing Patient Tobacco Cessation Counseling and Referrals for Patients With Cancer Undergoing Radiation Therapy

Conditions:   Breast Carcinoma;   Caregiver;   Head and Neck Carcinoma;   Lung Carcinoma;   Prostate Carcinoma;   Tobacco Use
Interventions:   Other: Communication Skills Training;   Other: Medical Chart Review;   Other: Questionnaire Administration;   Other: Tobacco Cessation Counseling
Sponsors:   OHSU Knight Cancer Institute;   National Cancer Institute (NCI)
Not yet recruiting - verified April 2017

http://ift.tt/2qvBfNY

Image Guided Surgery for Margin Assessment of Head and Neck Cancer Using Cetuximab-IRDye800CW cONjugate

Conditions:   Head and Neck Squamous Cell Carcinoma;   Margin Assessment
Intervention:   Drug: Cetuximab-IRDye800CW
Sponsors:   University Medical Center Groningen;   UMC Utrecht;   Erasmus Medical Center, Rotterdam
Not yet recruiting - verified April 2017

http://ift.tt/2pOLCQI

Wound Complications in Head and Neck Surgery

Conditions:   Hypothyroidism; Surgery;   Head and Neck Cancer;   Wound Heal;   Laryngeal Cancer;   Laryngeal Fistula
Intervention:   Drug: Levothyroxine
Sponsor:   University of Michigan
Not yet recruiting - verified April 2017

http://ift.tt/2qvDkcG

Synergistic Activity for Natural and Synthetic Inhibitors of Angiogenesis Induced by Murine Sarcoma L-1 and Human Kidney Cancer Cells.

Synergistic Activity for Natural and Synthetic Inhibitors of Angiogenesis Induced by Murine Sarcoma L-1 and Human Kidney Cancer Cells.

Adv Exp Med Biol. 2017 Apr 30;:

Authors: Bałan BJ, Siwicki AK, Pastewka K, Demkow U, Skopiński P, Skopińska-Różewska E, Lewicki S, Zdanowski R

Abstract
Tumor angiogenesis is an important link in the process of tumor growth and metastasis. A number of substances with an anti-angiogenic activity has been described, but their efficiency remains low. Many researchers believe that a better therapeutic effect could be achieved using a cocktail of several anti-angiogenic agents, having different points of action. A lot of synthetic and natural products of plant and animal origin have anti-tumor and anti-angiogenic properties. The aim of the present study was to evaluate the effect of some combinations of angiogenesis inhibitors on the growth and neovascularization of murine sarcoma L-1 , and on angiogenesis induced in the mouse skin by grafting of human renal cancer. The influence of theobromine, sulindac and its metabolite sulindac sulfone, chlorogenic acid, and shark liver oil on the afferent and efferent angiogenesis pathways was tested. Individually, all of these substances suppressed tumor growth and angiogenesis. Synergy was found for a combination of theobromine, sulindac, and chlorogenic acid (L-1 sarcoma tumor growth), and for theobromine with sulindac sulfone or with shark liver oil, which were given to the mice grafted with human renal cancer cells (angiogenesis). No synergistic effects were shown after preincubation with tumor cells and inhibitors.

PMID: 28456932 [PubMed - as supplied by publisher]

http://ift.tt/2px6xof

Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children.

Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children.

Curr Allergy Asthma Rep. 2017 May;17(5):34

Authors: Kwong CG, Bacharier LB

Abstract
PURPOSE OF REVIEW: Antibiotics are commonly used to treat wheezy lower respiratory tract illnesses in preschoolers, although these infections have been traditionally thought to be predominantly of viral origin. Our purpose is to review recent research pertaining to the role of antibiotics in lower respiratory tract illnesses and on subsequent asthma development, as well as the possible mechanisms of their effects.
RECENT FINDINGS: Increasing evidence suggests that asthma pathogenesis is associated with events during infancy and early childhood, particularly respiratory tract infections. While viruses are frequently detected in children with lower respiratory tract infections, the presence of potentially pathogenic bacteria is also often detected and may play a role in asthma pathogenesis. Recent evidence suggests that use of macrolides, particularly azithromycin, may decrease the risk of and duration of lower respiratory tract illnesses and prevent future episodes in specific high-risk populations. Infants and preschoolers who have wheezy lower respiratory tract illnesses have a higher risk of asthma development. Alterations in the microbiome are thought to be influential. While several recent studies identify azithromycin as a therapeutic option in these illnesses, additional research is needed.

PMID: 28456910 [PubMed - in process]

http://ift.tt/2oOSnlv

Inhaled Glucocorticoids and Pneumonia in Preterm Infants: Post Hoc Results from the NEuroSIS Trial.

Inhaled Glucocorticoids and Pneumonia in Preterm Infants: Post Hoc Results from the NEuroSIS Trial.

Neonatology. 2017 Apr 29;112(2):110-113

Authors: Koch A, Kreutzer K, von Oldershausen G, Poets CF, Bassler D, NEuroSIS Trial Group

Abstract
BACKGROUND: Inhaled glucocorticoids may increase the risk of pneumonia in adults. Thus, respiratory infections may be a potential explanation for the non-significantly increased mortality seen in the glucocorticoid group in the largest randomized trial on inhaled glucocorticoids for preventing bronchopulmonary dysplasia in preterm infants published to date (NEuroSIS).
OBJECTIVE: To evaluate the effect of inhaled budesonide on the risk of death due to respiratory infections in the NEuroSIS trial.
METHODS: We performed post hoc analyses of prospectively collected data from 856 preterm infants on presumed but not culture-proven sepsis and antimicrobial drug use. Additionally, pulmonary complications reported on adverse event forms, death certificates and autopsy reports were compared between study groups.
RESULTS: Treatment groups did not differ in the number of episodes with suspected sepsis (184/437 [42.1%] in the budesonide vs. 171/419 [40.8%] in the placebo group). Neither the number of patients receiving antimicrobial drugs nor the length of antimicrobial treatment differed between groups. Our analyses for pulmonary adverse events as well as for pulmonary complications reported on death certificates and autopsy reports did not suggest a negative impact of inhaled budesonide on these outcomes.
CONCLUSION: The current analysis does not support the assumption that respiratory tract infections explain the increased mortality seen in the glucocorticoid group in the NEuroSIS trial.

PMID: 28456800 [PubMed - as supplied by publisher]

http://ift.tt/2p0cwRw

Telescopic Corsair in 5F Guidion for Retrograde Recanalization of Complex Chronic Total Occlusions (CTOs).

Telescopic Corsair in 5F Guidion for Retrograde Recanalization of Complex Chronic Total Occlusions (CTOs).

Am J Case Rep. 2017 Apr 30;18:472-477

Authors: Palmers PJ, Maeremans J, Meyer-Gessner M, Bataille Y, Dens J

Abstract
BACKGROUND Retrograde advancement of microcatheters through septal/epicardial connectors can be challenging. Although several tricks might help to do so (e.g., balloon trap of retro wire in second guiding, balloon trap of retro wire in native coronary artery, and use of antegrade extension to approximate the antegrade conduit to the retrograde gear), these tricks cannot always be applied, especially in patients with poor access. Also, puncturing, knuckling, and crossing of the distal CTO cap (or the aorta as described in 1 of the cases) sometimes needs a lot of backup of the microcatheter. CASE REPORT We describe 3 cases in which we used a novel telescopic technique with 5F Guidion (IMDS®) supported retrograde Corsair (Asahi®) advancement in complex CTO lesions. CONCLUSIONS The telescopic Corsair in 5F Guidion may offer the support needed to end successfully in these situations.

PMID: 28456814 [PubMed - in process]

http://ift.tt/2pO9HH8