Altered patterns of resting-state functional connectivity between the caudate and other brain regions in medication-naïve children with attention deficit hyperactivity disorder

Publication date: Available online 28 July 2017
Source:Clinical Imaging
Author(s): Zhilong Yang, Hongxing Li, Wenjuan Tu, Suhong Wang, Yanling Ren, Yang Yi, Ting Wu, Kaihua Jiang, Huijuan Shen, Jian Wu, Xuan Dong
BackgroundStructural and functional alterations occur in the caudate of patients with attention-deficit/hyperactivity disorder (ADHD). Here we aimed to investigate the functional connectivity between the dorsal caudate and other brain regions in ADHD children.MethodsResting-state functional connectivity from 30 ADHD and 33 age- and gender-matched "normal" children were measured by functional Magnetic Resonance Imaging.ResultsPositive connectivity with dorsal caudate was observed in the prefrontal areas, cingulate cortex and temporal lobe. Negative functional connectivity was observed in the precuneus, occipital cortices and cerebellum. The connectivity of left dorsal caudate to left inferior frontal gyrus was correlated with severity of ADHD.ConclusionsConnectivity of dorsal caudate with several brain regions was identified in ADHD children.



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Diffusion-weighted imaging as a routine MRI protocol for the evaluation of ‘infantile hemangioma’

Publication date: Available online 28 July 2017
Source:Clinical Imaging
Author(s): Masahiro Kitami




http://ift.tt/2u668tC

Diffusion-weighted imaging for cutaneous vascular anomalies

Publication date: Available online 28 July 2017
Source:Clinical Imaging
Author(s): Mark D. Mamlouk, Andrew D. Nicholson, Daniel L. Cooke, Christopher P. Hess




http://ift.tt/2tQQWFk

A colorimetric and electrochemical immunosensor for point-of-care detection of enterovirus 71

Publication date: 15 January 2018
Source:Biosensors and Bioelectronics, Volume 99
Author(s): Yuan-Hui Hou, Jia-Jia Wang, Yong-Zhong Jiang, Cheng Lv, Li Xia, Shao-Li Hong, Miao Lin, Yi Lin, Zhi-Ling Zhang, Dai-Wen Pang
Point-of-care detection of human enterovirus 71 (EV71), the major pathogen that causes hand, foot, and mouth disease (HFMD) among children, is urgently needed for early diagnosis and control of related epidemics. A colorimetric and electrochemical immunosensor for point-of-care detection of EV71 has been developed based on dual-labeled magnetic nanobeads amplification. The dual-labeled magnetic nanobeads (DL-MBs) are fabricated by simultaneous immobilization of EV71 monoclonal antibody (mAb) and horseradish peroxidase (HRP) on magnetic nanobeads. By capturing EV71 virions in 20μL sample on mAb modified AuNPs-coated ITO electrode and subsequently binding with DL-MBs, with the addition of TMB and H2O2, colorimetric signals corresponding to EV71 with a concentration of 1.0ngmL⁻¹ can be directly read out by naked eyes, making it possible towards point-of-care detection of the virus. Furthermore, on the reduction of oxidized TMB on the electrode, electrochemical signal can be detected in the same detection cell without solution transfer, with a detection limit of 0.01ngmL⁻¹. Validated with clinical samples, the colorimetric and electrochemical immunosensor shows a complete consistency with reverse transcription-polymerase chain reaction (RT-PCR) results. So far as we know, this is the first report on EV71 detection using electrochemical method. The merits of this assay, including high sensitivity, ability for colorimetric detection and easy to operation, ensure a promising future in point-of-care diagnostics of virus related diseases.



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Fear Keeps Many Eczema Patients From Using Steroid Creams

Many people with eczema may avoid creams and ointments that can help ease symptoms like itching and inflammation because they're afraid to try topical corticosteroids, a recent study suggests.
Reuters Health Information

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Corrigendum to “Pre- and Poststimulation Study on the Phonatory Aerodynamic System on Participants with Dysphonia” [Journal of Voice 31 (2017) 254.e1–254.e9]

The authors regret excluding coauthor Sunyoung Kim from the original publication.

http://ift.tt/2uK1aVh

Detecting Laryngopharyngeal Reflux by Immunohistochemistry of Pepsin in the Biopsies of Vocal Fold Leukoplakia

Laryngopharyngeal reflux (LPR) may contribute to the development of laryngeal diseases including vocal fold leukoplakia. Clinical methods of determining LPR are limited. Pepsin, as an exogenous protein, is considered as a biomarker of LPR. The aim of the current study was, therefore, to detect pepsin by immunohistochemistry in the biopsies from patients with vocal fold leukoplakia, and by which, to determine the potential association of LPR and vocal leukoplakia. A total of 26 biopsies from patients with vocal fold leukoplakia were examined in comparison with 20 vocal fold biopsies from control subjects.

http://ift.tt/2tQwsfY