The safety of Lipistart, a medium-chain triglyceride based formula, in the dietary treatment of long-chain fatty acid disorders: a phase I study

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


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A Japanese patient with congenital central hypothyroidism caused by a novel IGSF1 mutation

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


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PRAC Seeks New Pregnancy Prevention Measures For Retinoids

The EMA committee calls for updating pregnancy prevention measures and including a warning with retinoid products on the possible risk for neuropsychiatric disorders.
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Editorial Board

Publication date: February 2018
Source:DNA Repair, Volume 62





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Reprint of: XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage in a cell cycle dependent manner

Publication date: February 2018
Source:DNA Repair, Volume 62
Author(s): Phillip R. Musich, Zhengke Li, Steven M. Shell, Yue Zou




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Neural synchronization: average strength vs. temporal patterning

Publication date: Available online 9 February 2018
Source:Clinical Neurophysiology
Author(s): Sungwoo Ahn, S. Elizabeth Zauber, Robert M. Worth, Thomas Witt, Leonid L. Rubchinsky




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Disruption of cortical synaptic homeostasis in individuals with chronic low back pain

Publication date: Available online 9 February 2018
Source:Clinical Neurophysiology
Author(s): Tribikram Thapa, Thomas Graven-Nielsen, Lucinda S. Chipchase, Siobhan M. Schabrun
ObjectiveHomeostatic plasticity mechanisms regulate synaptic plasticity in the human brain. Impaired homeostatic plasticity may contribute to maladaptive synaptic plasticity and symptom persistence in chronic musculoskeletal pain.MethodsWe examined homeostatic plasticity in fifty individuals with chronic low back pain (cLBP) and twenty-five pain-free controls. A single block (7-min) of anodal transcranial direct current stimulation ('single tDCS'), or two subsequent blocks (7-min and 5-min separated by 3-min rest; 'double tDCS'), were randomised across two experimental sessions to confirm an excitatory response to tDCS applied alone, and evaluate homeostatic plasticity, respectively. Corticomotor excitability was assessed in the corticomotor representation of the first dorsal interosseous muscle by transcranial magnetic stimulation-induced motor evoked potentials (MEPs) recorded before and 0, 10, 20, and 30-min following each tDCS protocol.ResultsCompared with baseline, MEP amplitudes increased at all time points in both groups following the single tDCS protocol (P<0.003). Following the double tDCS protocol, MEP amplitudes decreased in pain-free controls at all time points compared with baseline (P<0.01), and were unchanged in the cLBP group.ConclusionThese data indicate impaired homeostatic plasticity in the primary motor cortex of individuals with cLBP.SignificanceImpaired homeostatic plasticity could explain maladaptive synaptic plasticity and symptom persistence in cLBP.



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