Massive hemothorax due to two bleeding sources with minor injury mechanism: a case report

Massive hemothorax resulting from a minor injury mechanism is considered to be rare particularly when the diaphragm is injured. We report a case of massive hemothorax with bleeding from the intercostal artery ...

https://ift.tt/2pG3jzB

Innate immunosensing of DNA in cellular senescence

Selene Glück | Andrea Ablasser

https://ift.tt/2OLT23i

SAMHD1 and the innate immune response to cytosolic DNA during DNA replication

Flavie Coquel | Christoph Neumayer | Yea-Lih Lin | Philippe Pasero

https://ift.tt/2PgZGvh

Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance

Mark Noviski | Julie Zikherman

https://ift.tt/2Pp7rz6

The associations between mental health, health-related quality of life and insulin pump therapy among children and adolescents with type 1 diabetes

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2CvKveX

Impact of endodontic post material on longitudinal changes in interproximal bone level: a randomized controlled pilot trial

Abstract

Objectives

Aim was to evaluate the impact of glass fiber versus titanium endodontic posts on the interproximal bone level around severely damaged endodontically treated teeth.

Materials and methods

Thirty-eight participants of a randomized controlled trial on glass fiber (n = 18) and titanium post-endodontic restorations (n = 20) received radiographs at two different times after post placement (T0 = <12 months and T1 = 36–72 months after post placement). A total of 76 radiographs were analyzed with an image-editing software. Medians of changes in mesial and distal interproximal bone level (∆MBL, ∆DBL) were calculated and tested for statistical significance with respect to post material using Mann-Whitney U test (p < 0.05). Impact of post material on bone level changes was assessed in multilevel mixed-effect linear regression models.

Results

The mean observation period was 54 months for glass fiber and 50 months for titanium posts. Interproximal bone loss was small in both groups during the study period with no significant differences between groups (glass-fiber group, ∆MBL = − 0.03 mm and ∆DBL = − 0.06 mm; titanium group, ∆MBL = − 0.07 mm and ∆DBL = − 0.17 mm; both p > 0.05). Overall, impact of post material on bone loss was almost negligible with a nonsignificant difference between materials of 0.10 mm during the entire study period.

Conclusion

The rigidity of endodontic post material has no impact on the level of alveolar bone support of severely damaged endodontically treated teeth.

Clinical relevance

Post-endodontic restorations of severely damaged teeth can achieve steady levels of periodontal bone support as a parameter of periodontal health, irrespective of post material.

https://ift.tt/2PekDXO

Molecular isolation and characterization of the kisspeptin system, KISS and GPR54 genes in roach Rutilus rutilus —

Abstract

The reproduction of vertebrates is regulated by endocrine and neuro-endocrine signaling molecules acting along the brain-pituitary-gonad (BPG) axis. The understanding of the neuroendocrine role played in reproductive function has been recently revolutionized since the KiSS1/GPR54 (KiSS1r) system was discovered in 2003 in human and mice. Kisspeptins, neuropeptides that are encoded by the KiSS genes, have been recognized as essential in the regulation of the gonadotropic axis. They have been shown to play key roles in puberty onset and reproduction by regulating the gonadotropin secretion in mammals while physiological roles in vertebrates are still poorly known. In order to provide new knowledge on basic reproductive physiology in fish as well as new tools to assess impacts of endocrine disrupting compounds (EDCs), the neurotransmitter system, i.e., gene/receptor, KISS/GPR54 might constitute an appropriate biomarker. This study provides new understandings on the neuroendocrine regulation of roach reproduction as well as new molecular tools to be used as biomarkers of endocrine disruption. This work completes the set of biomarkers already validated in this species.

https://ift.tt/2yg0pWe