Regulatory dendritic cell (DC) markers, such as C1Q, are upregulated in PBMCs
Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy via Allergy and Clinical Immunology Publication date: Available online 29 October 2015 *Source:*Journal of Allergy and Clinical Immunology Author(s): Claire Gueguen, Julien Bouley, Hélène Moussu, Sonia Luce, Magalie Duchateau, Julia Chamot-Rooke, Marc Pallardy, Vincent Lombardi, Emmanuel Nony, Véronique Baron-Bodo, Laurent Mascarell, Philippe Moingeon BackgroundRegulatory dendritic cell (DC) markers, such a...περισσότερα »
Periostin expression with eosinophilic inflammation in nasal polyps
Association of via Allergy and Clinical Immunology Publication date: Available online 29 October 2015 *Source:*Journal of Allergy and Clinical Immunology Author(s): Min Wang, Xiangdong Wang, Nan Zhang, Hong Wang, Ying Li, Erzhong Fan, Liang Zhang, Luo Zhang, Claus Bachert
Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma
Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma via Hearing Research Publication date: Available online 28 October 2015 *Source:*Hearing Research Author(s): Shuzhi Yang, Qunfeng Cai, R. Robert Vethanayagam, Jianmin Wang, Weiping Yang, Bo Hua Hu Our previous RNA-sequencing analysis of the rat cochlear genes identified multiple biological processes and molecular pathways in the cochlear response to acoustic overstimulation. However, the biological processes and molecular pathways that are common to other ... περισσότερα »
The Hidden Dysfunction of Otolithic Organs
in Patients with Profound Sensorineural Hearing Loss via Hearing Research Publication date: Available online 28 October 2015 *Source:*Hearing Research Author(s): Xin-Da Xu, Chen-Ru Ding, Jing Yu, Zhao Han, Jun Gu, Na Gao, Xian-Hao Jia, Xu Luo, Jing Wang, Fang-Lu Chi ObjectiveTo define the profiles of ocular and cervical vestibular-evoked myogenic potentials (oVEMP and cVEMP, respectively) in patients with profound sensorineural hearing loss (PSHL).MethodsTwenty-nine patients with PSHL and 20 healthy volunteers were investigated. The patients’ medical records were collected and analyze...περισσότερα »
Tinnitus and hypersensitivity to sound (hyperacusis) in the gap detection test
Untangling the effects of via Hearing Research Publication date: Available online 28 October 2015 *Source:*Hearing Research Author(s): R.H. Salloum, S. Sandridge, D.J. Patton, G. Stillitano, G. Dawson, J. Niforatos, L. Santiago, J.A. Kaltenbach In recent years, there has been increasing use of the gap detection reflex test to demonstrate induction of tinnitus in animals. Animals with tinnitus show weakened gap detection ability for background noise that matches the pitch of the tinnitus. The usual explanation is that the tinnitus ‘fills in the gap’. It has recently been shown, however...περισσότερα »
Continuous 48 Hour Wireless Esophageal pH Monitoring in Children
: Comparison Between Days 1 and 2. by Ravi, Anupama; Gunasekaran, T.S.; Berman, J. via Journal of Pediatric Gastroenterology and Nutrition - Published Ahead-of-Print Aim: Comparison of days 1 and 2 to each other and to the total recording of 48hrs in continuous 48hr wireless esophageal pH monitoring in children. Methods: A retrospective study of 105 patients who underwent 48 hour pH monitoring (Bravo) studies between January 1992 to June 2010 was performed. Reflux variables were compared between days 1 and 2. Results: 58(55.2%) patients were male. Number of reflux episodes, number of l... περισσότερα »
Children with Feeding Difficulties
Clinical Characteristics of two Groups of Abstract Objectives: The primary aim of this study was to describe and compare the clinical characteristics of two groups of children presenting to a feeding clinic: children with Autism Spectrum Disorder (ASD) and children with a non-medically complex history (NMC). A secondary aim was to compare participants according to degree of oral motor impairment, presence of oral hypersensitivity, and clinically significant parent stress. Methods: Children with feeding difficulties aged between 2 and 6 years were recruited. Prospective data were coll... περισσότερα »
Extranodal soft tissue Rosai–Dorfman disease of the head and neck
and its diagnostic difficulty by Mika Yajima, Kyoko Nakajima, Junko Hirato, Kazuaki Chikamatsu via Auris Nasus Larynx Rosai–Dorfman disease (RDD) is a rare proliferative histiocytic disorder that is characterized by persistent massive lymphadenopathy mimicking malignant tumors. Extranodal RDD is uncommon, and more severe fibrosis and fewer histiocytes in lesions make the diagnosis of RDD more difficult than that of nodal RDD. We herein described a 31-year-old male patient with isolated soft tissue RDD of the head and neck. The patient was referred to our hospital with a right neck m... περισσότερα »
Novel retinoid ester in combination with salicylic acid for the treatment of acne
Summary Background Retinoids (RC), alpha-hydroxy acids (AHA), and salicylic acid (BHA) treat acne through differing mechanisms of action. It is theorized that optimal improvement can be achieved by combining the RC-induced normalization of cellular differentiation, AHA-induced exfoliation in hydrophilic areas, and BHA-induced exfoliation in lipophilic areas. AHA and RC have been combined in a bioengineered molecule (AHA retinoid conjugate, or AHA-RC) delivering both lactic acid (AHA) and RC in a manner reducing retinoid-associated irritation. Objectives To evaluate efficacy and ... περισσότερα »
Immunogenic, cellular, and angiogenic drivers of tumor dormancy – a melanoma view
Abstract In tumor cells the ability to maintain viability over long time periods without proliferation is referred to as a state of dormancy. Maintenance of dormancy is controlled by numerous cellular and environmental factors, from immune surveillance and tumor-stroma interaction to intracellular signaling. Interference of dormancy (to an "awaken" state) is associated with reduced response to therapy, resulting in relapse or in metastatic burst. Thus, maintaining a dormant state should prolong therapeutic responses and delay metastasis. Technical obstacles in studying tumor dorma... περισσότερα »
Phase II study of computed tomography-guided I-seed implantation plus chemotherapy for locally recurrent rectal cancer
This trial evaluated the efficacy and safety of CT guided 125I-seed implantation (CTII) plus chemotherapy with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment for locally recurrent rectal cancer (LRRC). from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1WmZdUg via IFTTT
Re: Division of the spinal accessory nerve in the anterior triangle: a prospective clinical study
In our recently reported prospective study of 133 neck dissections we found an interesting anatomical variant of the spinal accessory nerve in 3 patients (2%). It divided before entering the sternocleidomastoid, and the inferior trunk passed directly underneath the muscle to supply the trapezius.1 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1ioQMu7 via IFTTT
Pediatric Focused Safety Review Proton Pump Inhibitors
Pediatric Focused Safety Review Proton Pump Inhibitors www.fda.gov/.../*Pediatric*AdvisoryCommittee/UCM216303.pdf File Format: PDF/Adobe Acrobat Proton Pump Inhibitors in children Proton Pump Inhibitors in children E. Hassall (Vancouver) Published experience with proton pump inhibitors (PPI) in children has been limited to the use of omeprazole. Our experience with omeprazole in children to date suggests that the drug is invaluable for the treatment of certain children with severe or refractory gastroesophageal (GE) reflux, e.g., children with neurologic handicaps, cystic fibrosis, e... περισσότερα »
Narrow band CE-Chirp auditory steady-state response
is more reliable than the conventional ASSR in predicting the behavioral hearing threshold by Min Young Lee, Se Young Ahn, Hyun Ju Lee, Jae Yun Jung, Chung-Ku Rhee, Myung-Whan Suh via Auris Nasus Larynx We evaluated conventional ASSR (Bio-logic MASTER II) and NB CE-Chirp ASSR thresholds as objective hearing measures in both normal and hearing loss subjects. Methods Patients with sensorineural hearing loss and volunteer normal hearing subjects were enrolled. Pure tone thresholds at 0.5, 1, 2 and 4 kHz were compared with the corresponding thresholds measured using Bio-logic MASTER II... περισσότερα »
Parotid gland metastases of distant primary tumours
: A diagnostic challenge by Achim M. Franzen, Thomas Günzel, Anja Lieder via Auris Nasus Larynx Metastatic disease is common among parotid malignancies. The majority of primary tumours are located in the head and neck, but primary tumours below the clavicle must also be considered, especially in histological types not usually found in primary parotid or skin tumours. Methods We performed 644 consecutive parotidectomies between 1980 and 2012. Benign tumours were found in 555 patients (86%) and malignant tumours in 89 patients (14%). Results Of 89 malignant tumours, 39 were metastases (... περισσότερα »
Proton pump inhibitors in pediatrics : Prolonged treatment of pediatric patients with PPIs has not caused cancer or significant abnormalities
Br J Clin Pharmacol. 2015 Aug;80(2):200-8. doi: 10.1111/bcp.12619 *Adverse effects reported in the use of gastroesophageal reflux disease treatments in children*: a 10 years literature review. Cohen S1,2,3, Bueno de Mesquita M1,2, Mimouni FB2,3,4. Author information 1The Pediatric Gastroenterology unit. 2Department of Pediatrics, 'Dana-Dwek' Children's Hospital, Tel Aviv Medical Center and, the. 3Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel and. 4Division of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel. Abstract Gastroesophageal reflux (GER) is commonl... περισσότερα »
Podcast 159 – Rounding in the RACC
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Rounding on critically ill patients in the ED EMCrit by emcrit. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1WkW7Fo via IFTTT
Clinico-microbiological study of Pseudomonas aeruginosa in wound infections and the detection of metallo-β-lactamase production
Abstract *Pseudomonas aeruginosa* is a common opportunistic pathogen of humans among the Gram-negative bacilli. Clinically, it is associated with nosocomial infections like burns and surgical-site wound infections and remains a major health concern, especially among critically ill and immunocompromised patients. This is a prospective laboratory-based 2 year study conducted to isolate *P. aeruginosa* from wound specimens and the antimicrobial susceptibility pattern with reference to metallo-β-lactamase (MBL) production. Two hundred and twenty-four samples of *P. aeruginosa* isolated...περισσότερα »
Proton Pump Inhibitor Treatment in Children with Esophageal Eosinophilia.
High Prevalence of Response to by Gutiérrez-Junquera, Carolina; Fernández-Fernández, Sonia; Cilleruelo, M. Luz; Rayo, Ana; Echeverría, Luis; Quevedo, Sergio; Bracamonte, Teresa; Román, Enriqueta via Journal of Pediatric Gastroenterology and Nutrition - Published Ahead-of-Print Objectives: Proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is a newly recognized entity with an unclear prevalence in children, as only retrospective data are available. The aim of this study was to determine the prevalence and clinical features of PPI-REE in children. Methods: This prospec... περισσότερα »
Short Sleep Duration Is Related to Emerging Cardiovascular Risk Factors in Obese Children
Short Sleep Duration Is Related to Emerging Cardiovascular Risk Factors in Obese Children by Navarro-Solera, María; Carrasco-Luna, Joaquín; Pin-Arboledas, Gonzalo; González-Carrascosa, Rebeca; Soriano, José M.; Codoñer-Franch, Pilar via Journal of Pediatric Gastroenterology and Nutrition - Current Issue Objective: The aim of the present study was to evaluate the influence of sleep duration on cardiovascular risk factors in obese children. Methods: Cross-sectional analysis of 90 obese children ages 7 to 16 years. Anthropometric and clinical evaluation with specification of dietary and ...περισσότερα »
Eradication of Candida Central Venous Catheter Infection With Ambisome Line Lock
Journal of Pediatric Gastroenterology & Nutrition: November 2015 - Volume 61 - Issue 5 - p e24–0 doi: 10.1097/MPG.0000000000000918 Letters to the Editor Successful Eradication of Candida Central Venous Catheter Infection With Ambisome Line Lock in Factitious Illness Guest, Timothy; Ashbee, Ruth; Puntis, John
Human Milk Fortification Increases Bnip3 Expression Associated With Intestinal Cell Death
In Vitro by Diehl-Jones, William; Archibald, Alyssa; Gordon, Joseph W.; Mughal, Wajihah; Hossain, Zakir; Friel, James K. viaJournal of Pediatric Gastroenterology and Nutrition - Current Issue Objectives: The aim of the present study was to determine the in vitro effect(s) of a bovine-based human breast milk fortifier (HMF) on human intestinal cells. HMF increases the expression of BCL2/adenovirus E1B 19 kDa protein-interacting protein (Bnip3) and cell death; the prostaglandin analogue misoprostol will rescue this effect. Methods: Cultured intestinal cells were exposed to in vitro–di... περισσότερα »
Psoriasis at a Gastrostomy Tube Site
Journal of Pediatric Gastroenterology & Nutrition: November 2015 - Volume 61 - Issue 5 - p e21 doi: 10.1097/MPG.0000000000000334 Image of the Month Koebner Phenomenon: Psoriasis at a Gastrostomy Tube Site Felix, Grace; Kirkorian, A. Yasmine; Cohen, Bernard; Karnsakul, Wikrom
Plummer-Vinson syndrome (PVS), also called Kelly-Paterson syndrome, is a rare cause of dysphagia in children
Plummer-Vinson Syndrome in Children by Butori, Mathilde; Mahmoudi, Sana; Dugelay-Ecochard, Emmanuelle; Belarbi, Nadia; Bellaïche, Marc; Hugot, Jean-Pierre; Viala, Jérôme via Journal of Pediatric Gastroenterology and Nutrition - Current Issue [image: image] Objectives: Plummer-Vinson syndrome (PVS), also called Kelly-Paterson syndrome, is a rare cause of dysphagia in children. This syndrome associates single or multiple webs in the upper esophagus with frequent iron deficiency. Methods: We reported 3 pediatric cases of PVS before analyzing all of the cases of PVS in children reported i...περισσότερα »
Esophagram to the Evaluation of Complicated Pediatric Eosinophilic Esophagitis
Contribution of by Menard-Katcher, Calies; Swerdlow, Mathew P.; Mehta, Pooja; Furuta, Glenn T.; Fenton, Laura Z. via Journal of Pediatric Gastroenterology and Nutrition - Current Issue [image: image] Objectives: In contrast to peptic strictures, clinically significant strictures in patients with eosinophilic esophagitis (EoE) may be subtle and go unrecognized at the time of endoscopy. We aimed to identify how often stricture was identified by endoscopy as compared with contrast esophagram. Methods: We retrospectively reviewed esophagram and endoscopy examinations of all of the patie...περισσότερα »
Childhood Esophagitis
Changes in 30 Years at 1 Center by Memon, Zebunnissa; Baker, Robert D.; Khan, Abdur; Baker, Susan S. via Journal of Pediatric Gastroenterology and Nutrition - Current Issue ABSTRACT: Eosinophils are nonspecific harbingers of esophageal disease. We report on the incidence and features of esophageal eosinophilia diagnosed at our center in 2011 and compare the findings with previously published results between 1980–1988 and 2000–2002. Eosinophils per high-power field were counted in esophageal biopsies from 675 patients who underwent 710 endoscopic procedures between January 1, 2011, an... περισσότερα »
Eosinophilic Esophagitis
Journal of Pediatric Gastroenterology & Nutrition: November 2015 - Volume 61 - Issue 5 - p 529–530 doi: 10.1097/MPG.0000000000000960 Invited Commentary Sergi, Consolato
Divine Proportions
The Role of Ideal Angles, Ratios, and Divine Proportions in Aesthetic Evaluation of Adolescents via Latest Results for Aesthetic Plastic Surgery AbstractObjectivesThe aim of our study was to investigate whether the parameters of ideal angles, ratios, and divine proportions that have been previously mentioned in the literature influence the aesthetic evaluation of Turkish adolescents. Materials and MethodsA total of sixty patients (30 males and 30 females) were enrolled in this study. Ages of the subjects ranged from 9 to 17. Pre-treatment extra-oral photographs were taken to evaluate ...περισσότερα »
Hearing Loss
Revealing Hearing Loss: A Survey of How People Verbally Disclose Their Hearing Loss. by West, Jessica S.; Low, Jacob C. M.; Stankovic, Konstantina M. via Ear and Hearing - Published Ahead-of-Print Objective: Hearing loss is the most common sensory deficit and congenital anomaly, yet the decision-making processes involved in disclosing hearing loss have been little studied. To address this issue, we have explored the phrases that adults with hearing loss use to disclose their hearing loss. Design: Since self-disclosure research has not focused on hearing loss-specific issues, we creat... περισσότερα »
Oral lesions, chronic diseases and the risk of head and neck cancer
Oral lesions, chronic diseases and the risk of head and neck cancer by Shuang Li, Yuan-chin Amy Lee, Qian Li, Chien-Jen Chen, Wan-Lun Hsu, Pen-Jen Lou, Cairong Zhu, Jian Pan, Hongbing Shen, Hongxia Ma, Lin Cai, Baochang He, Yu Wang, Xiaoyan Zhou, Qinghai Ji, Baosen Zhou, Wei Wu, Jie Ma, Paolo Boffetta, Zuo-Feng Zhang, Min Dai, Mia Hashibe via Oral Oncology The aim of our study is to explore the role of the history of oral lesions and chronic diseases on the risk of head and neck cancer in a Chinese population. Materials and methods Our case-control study included 921 head and neck can...περισσότερα »
Tumor-Associated Endothelial Cells Promote Tumor Metastasis
by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis by Arti Yadav et al. via PLOS ONE by Arti Yadav, Bhavna Kumar, Jun-Ge Yu, Matthew Old, Theodoros N. Teknos, Pawan Kumar Tumor metastasis is a highly inefficient biological process as millions of tumor cells are released in circulation each day and only a few of them are able to successfully form distal metastatic nodules. This could be due to the fact that most of the epithelial origin cancer cells are anchorage-dependent and undergo rapid anoikis in harsh circulating conditions. A number of studies have shown th...περισσότερα »
Transmediastinal Trachea Closure after Dilational Tracheotomy
Transmediastinal Trachea Closure after Dilational Tracheotomy Positioned Too Low Down by Kirschbaum, Andreas via The Thoracic and Cardiovascular Surgeon Reports THORAC CARDIOV SURG Reports DOI: 10.1055/s-0035-1566263 Dilational tracheotomy is a minimally invasive method that can be performed at the bedside on patients requiring long-term mechanical ventilation. In our 70-year-old male patient, percutaneous dilational tracheotomy (Ciaglia Blue Rhino, Cook Medical Inc., Bloomington, Indiana, United States) was performed because of bilateral pneumonia with sepsis. There were no initial p...περισσότερα »
Minimally-Invasive Left Ventricular Assist Device Implantation without any Blood Transfusions
Heart Failing Jehovah Witness Patient Successfully Treated by by Böning, Andreas via The Thoracic and Cardiovascular Surgeon Reports THORAC CARDIOV SURG Reports DOI: 10.1055/s-0035-1565252 Left ventricular assist device (LVAD) implantation without the use of any blood products is considered as a challenge. We present a 48-year-old patient (175 cm, 75 kg, body mass index 24.5 kg/m2) who was admitted to our clinic due to end-stage heart failure. The patient is a Jehovah's witness. He declined full blood transfusion as well as use of coagulation factors. Therefore, we interdisciplinary ...περισσότερα »
Prominence of Medullary Veins on Susceptibility-Weighted Images Provides Prognostic Information in Patients with Subacute Stroke [ADULT BRAIN]
BACKGROUND AND PURPOSE: The demonstration of prominent medullary veins in the deep white matter ipsilateral to acute ischemic stroke has been shown to predict poor clinical outcome. We have investigated the prognostic implications of prominent medullary veins in patients with subacute stroke who present outside the therapeutic window for revascularization therapy. MATERIALS AND METHODS: Forty-three consecutive patients with ischemic stroke in the middle cerebral artery territory presenting within 3–7 days of ictus were enrolled. The presence of prominent medullary veins in the p...περισσότερα »
Endovascular Treatment of Unruptured Paraclinoid Aneurysms: Single-Center Experience with 400 Cases and Literature Review [ADULT BRAIN]
BACKGROUND AND PURPOSE: Paraclinoid aneurysms have been increasingly treated endovascularly. The natural history of these aneurysms has gradually been elucidated. The purpose of this study was to assess the safety and efficacy of endovascular treatment for these aneurysms. MATERIALS AND METHODS: We performed a retrospective review of 377 patients with 400 paraclinoid aneurysms treated between January 2006 and December 2012. Their clinical records, endovascular reports, and radiologic and clinical outcomes were analyzed. Because aneurysms ≥7 mm are at higher risk of rupture, we ... περισσότερα »
Diagnostic Accuracy of Transcranial Doppler for Brain Death Confirmation: Systematic Review and Meta-Analysis [ADULT BRAIN]
BACKGROUND AND PURPOSE: Transcranial Doppler is a useful ancillary test for brain death confirmation because it is safe, noninvasive, and done at the bedside. Transcranial Doppler confirms brain death by evaluating cerebral circulatory arrest. Case series studies have generally reported good correlations between transcranial Doppler confirmation of cerebral circulatory arrest and clinical confirmation of brain death. The purpose of this study is to evaluate the utility of transcranial Doppler as an ancillary test in brain death confirmation. MATERIALS AND METHODS: We conducted ... περισσότερα »
Variability of Forebrain Commissures in Callosal Agenesis: A Prenatal MR Imaging Study [PEDIATRICS]
BACKGROUND AND PURPOSE: Agenesis of the corpus callosum, even when isolated, may be characterized by anatomic variability. The aim of this study was to describe the types of other forebrain commissures in a large cohort of randomly enrolled fetuses with apparently isolated agenesis of the corpus callosum at prenatal MR imaging. MATERIALS AND METHODS: All fetuses with apparent isolated agenesis of the corpus callosum undergoing prenatal MR imaging from 2004 to 2014, were evaluated for the presence of the anterior or a vestigial hippocampal commissure assessed in consensus by 2 p... περισσότερα »
Retrospective Analysis of Delayed Intraparenchymal Hemorrhage after Flow-Diverter Treatment: Presentation of a Retrospective Multicenter Trial [ADULT BRAIN]
BACKGROUND AND PURPOSE: Intracranial aneurysm treatment with flow diverters has shown satisfying results in terms of aneurysm occlusion, and while some cases of delayed intraparenchymal hemorrhage have been described, no systematic analysis of the risk factors affecting its occurrence has been conducted in a large series of patients. This retrospective analysis of delayed intraparenchymal hemorrhage after flow-diverter treatment is a multicenter, retrospective study using a large series of treated patients to analyze factors affecting the occurrence of delayed intraparenchymal he...περισσότερα »
3D T2 MR Imaging-Based Measurements of the Posterior Cervical Thecal Sac in Flexion and Extension for Cervical Puncture [INTERVENTIONAL]
BACKGROUND AND PURPOSE: The current standard technique for cervical puncture involves prone positioning with neck extension. The purpose of this study was to compare measurements of the posterior cervical thecal sac during neck flexion and extension in supine and prone positions by using high-resolution MR imaging to help determine the optimal positioning for cervical puncture. MATERIALS AND METHODS: High-resolution T2-weighted MR imaging was performed of the cervical spine in 10 adult volunteers 18 years of age and older. Exclusion criteria included the following: a history of ... περισσότερα »
Normal Development and Measurements of the Occipital Condyle-C1 Interval in Children and Young Adults [SPINE]
BACKGROUND AND PURPOSE: Widening of the occipital condyle-C1 interval is the most specific and sensitive means of detecting atlanto-occipital dislocation. Recent studies attempting to define normal measurements of the condyle-C1 interval in children have varied substantially. This study was performed to test the null hypothesis that condyle-C1 interval morphology and joint measurements do not change as a function of age. MATERIALS AND METHODS: Imaging review of subjects undergoing CT of the upper cervical spine for reasons unrelated to trauma or developmental abnormality was per...περισσότερα »
Multimodal Imaging in Malignant Brain Tumors: Enhancing the Preoperative Risk Evaluation for Motor Deficits with a Combined Hybrid MRI-PET and Navigated Transcranial Magnetic Stimulation Approach [ADULT BRAIN]
BACKGROUND AND PURPOSE: Motor deficits in patients with brain tumors are caused mainly by irreversible infiltration of the motor network or by indirect mass effects; these deficits are potentially reversible on tumor removal. Here we used a novel multimodal imaging approach consisting of structural, functional, and metabolic neuroimaging to better distinguish these underlying causes in a preoperative setting and determine the predictive value of this approach. MATERIALS AND METHODS: Thirty patients with malignant brain tumors involving the central region underwent a hybrid O-(2-... περισσότερα »
Long Term Results of Surgical Treatment for Dermatofibrosarcoma Protuberans According to Width of Gross Resection Margin
Controversy exists regarding appropriate surgical treatment for dermatofibrosarcoma protuberans (DFSP). The purpose of this study was to propose a treatment recommendations based on long term result of surgical treatments for DFSP. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1WmISyX via IFTTT
Neuregulin-1 released by biodegradable gelatin hydrogels can accelerate facial nerve regeneration and functional recovery of traumatic facial nerve palsy
Neuregulin-1 is an essential axoglial signal required for peripheral nerve development, and there is growing evidence that neuregulin-1 is also required for effective nerve repair. In this study, the effects of neuregulin-1-impregnated gelatin hydrogels on nerve regeneration and functional recovery after anastomosis of the facial nerve were investigated in a rat model of traumatic facial nerve paralysis. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1WmIOzc via IFTTT
Multiple Etiologies of Trigger Wrist
Trigger wrist, a relatively unusual condition, is a triggering at the wrist produced by wrist or finger motion. We evaluated the clinical manifestations and surgical results of trigger wrist with multiple etiologies. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1GOhyaS via IFTTT
Long-Term Orthognathic Surgical Outcomes in Treacher Collins Patients
Treacher Collins syndrome is a rare disorder characterized by several orofacial findings including malar deficiency and hypoplastic mandibles. These patients often require a combined orthodontic-orthognathic approach to correct their malocclusion. This is most often characterized by a short posterior vertical height and anterior open bite. Orthognathic correction often requires Le Fort I and bilateral sagittal split osteotomies. There have been no reported long-term stability results after bimaxillary surgery in Treacher Collins patients. from #Aesthetics via alexandrossfakianakis... περισσότερα »
Functional and anatomical basis for brain plasticity in facial palsy rehabilitation using the masseteric nerve
Several techniques have been described for smile restoration after facial nerve paralysis. When a nerve other than the contralateral facial nerve is used to restore the smile, some controversy appears because of the non-physiological mechanism of smile recovering. Different authors have reported natural results with the masseter nerve. The physiological pathways which determine whether this is achieved remain unclear.Brain activation pattern measuring Blood-Oxygen-Level-Dependent (BOLD) signal during smiling and jaw-clenching was recorded in a group of 24 healthy subjects (11 fema...περισσότερα »
A Low Cost Method of Craniofacial Distraction Osteogenesis
Distraction osteogenesis is an effective treatment modality for the correction of craniofacial deformities. The cost of these devices is significant and may preclude routine use of these distractors in developing countries. Hence distraction osteogenesis was performed using medical equipment readily available in any hospital at minimal cost. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1WmIKiW via IFTTT
The Marginal Branch Triangle: Anatomic reference for its location and preservation during cosmetic surgery
Many studies have been dedicated toward bettering the understanding of the anatomy of this branch and the relative danger zone. However most of these articles have focused on identifying the location of this branch based on its trajectory and relations with deep structures, bringing some difficulties for aesthetic surgeons to identify its location during facial aesthetic surgery.Here, we present the concept of the marginal nerve triangle; its contents, relations and clinical applications in cosmetic surgery are discussed. from #Aesthetics via alexandrossfakianakis on Inoreader ht... περισσότερα »
Surgical Treatment of Paediatric Nail Bed Injuries in the United Kingdom: Surgeon and Patient Priorities for Future Research
Nail bed injuries are the most common paediatric hand injury, yet there is a limited evidence base to guide treatment. The aim of this study was to gather information on current practice to help inform future clinical research. We conducted an online survey of hand surgeons and a retrospective audit of nail bed injuries managed at four plastic surgery units. In addition, we surveyed parents of children with nail bed injuries to identify their concerns regarding the injury. Overall, 84% of hand surgeons surgically repair paediatric nail bed injuries. from #Aesthetics via alexandros... περισσότερα »
Evaluation of the first web space narrowing in congenital anomalies with Z-deformity
In patients with congenital anomalies of the thumb, the metacarpophalangeal joint often undergoes radial deviation to compensate for a narrow first web space. Here we evaluated the relationship between the thumb and index finger in patients with arthrogryposis multiplex congenita (AMC), by measuring the thumb-index angle on radiographs taken while the patient held a styrene foam cone. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1GOhpUV via IFTTT
Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure
in Adult Mice by Kass, M. D., Guang, S. A., Moberly, A. H., McGann, J. P. via Chemical Senses The adult olfactory system undergoes experience-dependent plasticity to adapt to the olfactory environment. This plasticity may be accompanied by perceptual changes, including improved olfactory discrimination. Here, we assessed experience-dependent changes in the perception of a homologous aldehyde pair by testing mice in a cross-habituation/dishabituation behavioral paradigm before and after a week-long ester-odorant exposure protocol. In a parallel experiment, we used optical neurophysio... περισσότερα »
Saccharin Taste Conditions Flavor Preference
in Weanling Rats by Ueji, K., Minematsu, Y., Takeshita, D., Yamamoto, T. via Chemical Senses Innate and learned taste/flavor preferences to chemical stimuli in weanling rats are not fully understood. Our previous study showed that weanling rats could establish conditioned flavor preferences when low, but not high, concentrations of sucrose solutions were used as associative rewarding stimuli. Here, we examined whether 3-week-old rats could acquire flavor learning when the rewarding stimulus was saccharin, a non-nutritive artificial sweetener. In the acquisition session, they consumed...περισσότερα »
Subtemporal Retrolabyrinthine (Posterior Petrosal) versus Endoscopic Endonasal Approach to the Petroclival Region
: An Anatomical and Computed Tomography Study by Mason, Eric via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B DOI: 10.1055/s-0035-1566123 Background The petroclival region seats many neoplasms. Traditional surgical corridors to the region can result in unacceptable patient morbidity. The combined subtemporal retrolabyrinthine transpetrosal (posterior petrosal) approach provides adequate exposure with hearing preservation; however, the facial nerve and labyrinth are put at risk. Approaching the petroclival region with an endoscopic endonasal approach (EEA) could m...περισσότερα »
Directional microphone technology
The Verifit Directional Mic Test: Evaluating Modern Directional Microphone Technologies via Audiology Directional microphone technology has been available for nearly fifty years, and remains even to this day, the single most effective approach to improving signal-to-noise ratio (SNR) for certain listening conditions within a “head-worn” hearing instrument device (Lybarger & Lybarger, 2000). Why is improving SNR important? Because even modest improvements can have a significant impact on speech intelligibility, particularly in less reverberant environments. As Harvey Dillon (2006) has... περισσότερα »
The pathogenesis of sarcomatous component in spindle cell carcinoma (SpCC) of the esophagus
Wide expression of ZEB1 in sarcomatous component of spindle cell carcinoma of the esophagus by Takuro Nakazawa, Sumihito Nobusawa, Hayato Ikota, Hiroyuki Kuwano, Izumi Takeyoshi, Hideaki Yokoo via Pathology International The pathogenesis of sarcomatous component in spindle cell carcinoma (SpCC) of the esophagus is unclear. To investigate the involvement of epithelial-mesenchymal transition (EMT) in sarcomatous differentiation, we performed immunohistochemistry for Slug, Twist, ZEB1, and ZEB2, transcription factors associated with EMT and E-cadherin, in 14 cases of SpCC of the esophag... περισσότερα »
Endovascular Treatment of Unruptured Paraclinoid Aneurysms
: Single-Center Experience with 400 Cases and Literature Review [ADULT BRAIN] by Shimizu, K., Imamura, H., Mineharu, Y., Adachi, H., Sakai, C., Sakai, N. via Neuroradiology BACKGROUND AND PURPOSE:Paraclinoid aneurysms have been increasingly treated endovascularly. The natural history of these aneurysms has gradually been elucidated. The purpose of this study was to assess the safety and efficacy of endovascular treatment for these aneurysms. MATERIALS AND METHODS:We performed a retrospective review of 377 patients with 400 paraclinoid aneurysms treated between January 2006 and Decembe... περισσότερα »
Arf6 regulation of Schwann cell differentiation and myelination
Data supporting via ScienceDirect Publication: Data in Brief Publication date: December 2015 *Source:*Data in Brief, Volume 5 Author(s): Tomohiro Torii, Yuki Miyamoto, Masahiro Yamamoto, Katsuya Ohbuchi, Hideki Tsumura, Kazuko Kawahara, Akito Tanoue, Hiroyuki Sakagami, Junji Yamauchi The data is related to the research article entitled “Arf6 mediates Schwann cell differentiation and myelination” [1]. To further investigate the role of Arf6 in promoting myelination by Schwann cells in vivo, we have characterized an another line (#2) of small-hairpin (sh)RNA transgenic mice targeting A...περισσότερα »
Antioxidant activity in grapevine (Vitis vinifera L.)
Data on antioxidant activity in grapevine (Vitis vinifera L.) following cryopreservation by vitrification via ScienceDirect Publication: Data in Brief Publication date: December 2015 *Source:*Data in Brief, Volume 5 Author(s): María Fernanda Lazo-Javalera, Martín Ernesto Tiznado-Hernández, Irasema Vargas-Arispuro, Elisa Valenzuela-Soto, María del Carmen Rocha-Granados, Marcos Edel Martínez-Montero, Marisela Rivera-Domínguez Cryopreservation is used for the long-term conservation of plant genetic resources. This technique very often induces lethal injury or tissue damage. In this study,...περισσότερα »
Pollen loads of eucalypt and other pollen types in birds
in NW Spain via ScienceDirect Publication: Data in Brief Publication date: December 2015 *Source:*Data in Brief, Volume 5 Author(s): María Calviño-Cancela, Max Neumann Here we present the amount of pollen of eucalypt and pollen of other types for birds captured in two bird ringing stations for 14 months (March 2014 to April 2015) in NW Spain. Common and latin names of all birds species captured, together with the number of captured individuals (N), prevalence of eucalypt pollen (percentage of individuals with eucalypt pollen) and of pollen of other types and average pollen loads per i... περισσότερα »
Gas within the portal venous system is often considered a pre-morbid radiological sign
Extensive portal venous gas in a post-operative patient with no identifiable cause by Hussein, A., Makhija, R. via Journal of Surgical Case Reports - current issue Gas within the portal venous system is often considered a pre-morbid radiological sign. We present a case of extensive portal venous gas (PVG) identified in a patient 6 days following emergency Hartmann's procedure for large bowel obstruction. The patient underwent re-laparotomy on the basis of these radiological findings, but no clear cause was identified. She went on to have an uneventful recovery. Of interest is the dis... περισσότερα »
Isatin-Schiff Copper(II) Complexes : Inhibition of the Hemolytic Activity caused by Staphylococcus aureus alpha-Hemolysin
Inhibition of the Hemolytic Activity caused by Staphylococcus aureus alpha-Hemolysin through Isatin-Schiff Copper(II) Complexes by Melo, M. C. A., Teixeira, L. R., Pol-Fachin, L., Rodrigues, C. G. via http://femsle.oxfordjournals.org/rss/ahead.xml A great number of pathogens secrete pore-forming proteins during infection. Such molecules, from either bacterial or viral origin, are considered important virulence factors, which makes them attractive targets in the study of new therapeutic agents. Thus, the inhibitory activity of Isatin-Schiff base copper(II) complexes was evaluated again... περισσότερα »
Arterial input function and gray matter cerebral blood volume measurements
in children by Stephanie B. Withey, Jan Novak, Lesley MacPherson, Andrew C. Peet via Journal of Magnetic Resonance Imaging [image: cover.gif?v=1&s=a3d3423fc4022cca72f8dfe7] Purpose To investigate how arterial input functions (AIFs) vary with age in children and compare the use of individual and population AIFs for calculating gray matter CBV values. Quantitative measures of cerebral blood volume (CBV) using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) require measurement of an AIF. AIFs are affected by numerous factors including patient age. Few data prese... περισσότερα »
Incidence of Gastric Cancer after Endoscopic Resection of Gastric Adenoma
The annual incidence of metachronous cancer after endoscopic resection (ER) of early gastric cancer (EGC) is approximately 3%. However, incidence of gastric cancer after ER of gastric adenoma is not known. The aim of this study was to determine whether the incidence of gastric cancer after ER of gastric adenoma was different compared with the metachronous cancer after ER of EGC. from Endocrinology via ola Kala on Inoreader http://ift.tt/1ObUshe via IFTTT
Multicenter prospective crossover trial comparing the door knocking method with the conventional method for EUS-FNA of solid pancreatic masses (with videos)
There are presently no prospective controlled trials of needle puncture speed in endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA). In the present study, we prospectively evaluated the accuracy of histological diagnosis and the tissue acquisition rate of EUS-FNA using the door knocking method (DKM) with a standard 22-gauge needle. from Endocrinology via ola Kala on Inoreader http://ift.tt/1kfKuy6 via IFTTT
Endoscopic intestinal bypass creation using self-assembling magnets in a porcine model
A purely endolumenal method of GI bypass would be desirable for treatment of obstruction, obesity or metabolic syndrome. We have developed a technology based on miniature self-assembling magnets which create large-caliber anastomoses (Incisionless Anastomosis System [IAS]). The aim of this study was to evaluate procedural characteristics of IAS deployment and long-term anastomotic integrity and patency. from Endocrinology via ola Kala on Inoreader http://ift.tt/1ObUrd1 via IFTTT
Lectin staining and Western blot data showing differential sialylation of nutrient-deprived cancer cells to sialic acid supplementation
Publication date: December 2015 *Source:*Data in Brief, Volume 5 Author(s): Haitham A. Badr, Dina M.M. AlSadek, Mohit P. Mathew, Chen-Zhong Li, Leyla B. Djansugurova, Kevin J. Yarema, Hafiz Ahmed This report provides data that are specifically related to the differential sialylation of nutrient deprived breast cancer cells to sialic acid supplementation in support of the research article entitled, "Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation" [1]. Particularly, breast cancer cells, when supplemented with sialic acid under nutr... περισσότερα »
Inhibition of the Hemolytic Activity caused by Staphylococcus aureus alpha-Hemolysin through Isatin-Schiff Copper(II) Complexes
A great number of pathogens secrete pore-forming proteins during infection. Such molecules, from either bacterial or viral origin, are considered important virulence factors, which makes them attractive targets in the study of new therapeutic agents. Thus, the inhibitory activity of Isatin-Schiff base copper(II) complexes was evaluated against membrane damage activity of *Staphylococcus aureus* α-hemolysin (α-HL). For this purpose, a standard hemolysis assay with rabbit erythrocytes and micromolar concentrations of the compounds was employed. Additionally, planar artificial lipid ...περισσότερα »
Scale-dependent effects of climate and geographic distance on bacterial diversity patterns across northern China's grasslands
Patterns of variation in plant and animal diversity along precipitation gradients have been extensively studied, but much less is known about how and to what extent precipitation affects the biogeographic distribution of microbial diversity in arid areas across large spatial scales. Here we collected soils from 54 sites along a 3,700 km transect covering a wide range of grassland ecosystems with distinct aridity gradients. We quantified the bacterial community diversity and the effects of climate, edaphic parameter and geographic distance on the bacterial community structure using... περισσότερα »
The Marginal Branch Triangle
: Anatomic reference for its location and preservation during cosmetic surgery by Percy Rossell-Perry via Plastic, Reconstructive & Aesthetic Surgery Background Many studies have been dedicated toward bettering the understanding of the anatomy of this branch and the relative danger zone. However most of these articles have focused on identifying the location of this branch based on its trajectory and relations with deep structures, bringing some difficulties for aesthetic surgeons to identify its location during facial aesthetic surgery. Here, we present the concept of the marginal ne...περισσότερα »
Craniofacial Distraction Osteogenesis
A Low Cost Method of by Gerhardus A. Greyvensteyn, Anil Madaree via Plastic, Reconstructive & Aesthetic Surgery Distraction osteogenesis is an effective treatment modality for the correction of craniofacial deformities. The cost of these devices is significant and may preclude routine use of these distractors in developing countries. Hence distraction osteogenesis was performed using medical equipment readily available in any hospital at minimal cost. Patients and Methods A retrospective study was performed on infants and neonates who underwent primary distraction for craniofacial a... περισσότερα »
Brain plasticity in facial palsy rehabilitation using the masseteric nerve
Functional and anatomical basis for by Javier Buendia, Francis R. Loayza, Elkin O. Luis, Marta Celorrio, Maria A. Pastor, Bernardo Hontanilla via Plastic, Reconstructive & Aesthetic Surgery Summary Several techniques have been described for smile restoration after facial nerve paralysis. When a nerve other than the contralateral facial nerve is used to restore the smile, some controversy appears because of the non-physiological mechanism of smile recovering. Different authors have reported natural results with the masseter nerve. The physiological pathways which determine whether th... περισσότερα »
Orthognathic Surgical Outcomes in Treacher Collins Patients
Long-Term by P.D. Nguyen, M.C. Caro, D.M. Smith, B. Tompson, C.R. Forrest, J.H. Phillips via Plastic, Reconstructive & Aesthetic Surgery Intro Treacher Collins syndrome is a rare disorder characterized by several orofacial findings including malar deficiency and hypoplastic mandibles. These patients often require a combined orthodontic-orthognathic approach to correct their malocclusion. This is most often characterized by a short posterior vertical height and anterior open bite. Orthognathic correction often requires Le Fort I and bilateral sagittal split osteotomies. There have b...περισσότερα »
Neuregulin-1 released by biodegradable gelatin hydrogels can accelerate facial nerve regeneration and functional recovery
of traumatic facial nerve palsy by Go Yasui, Yuhei Yamamoto, Ryuji Shichinohe, Emi Funayama, Akihiko Oyama, Toshihiko Hayashi, Hiroshi Furukawavia Plastic, Reconstructive & Aesthetic Surgery Neuregulin-1 is an essential axoglial signal required for peripheral nerve development, and there is growing evidence that neuregulin-1 is also required for effective nerve repair. In this study, the effects of neuregulin-1-impregnated gelatin hydrogels on nerve regeneration and functional recovery after anastomosis of the facial nerve were investigated in a rat model of traumatic facial nerve p... περισσότερα »
Surgical Treatment for Dermatofibrosarcoma Protuberans
Long Term Results of Surgical Treatment for Dermatofibrosarcoma Protuberans According to Width of Gross Resection Margin by Kyong-Je Woo, Sa Ik Bang, Goo-Hyun Mun, Kap Sung Oh, Jai-Kyong Pyon, So Young Lim via Plastic, Reconstructive & Aesthetic Surgery Controversy exists regarding appropriate surgical treatment for dermatofibrosarcoma protuberans (DFSP). The purpose of this study was to propose a treatment recommendations based on long term result of surgical treatments for DFSP. Methods We retrospectively reviewed 63 patients who underwent surgical resection for primary DFSP from 1... περισσότερα »
Hen's egg allergy in the first 2 years of life
Incidence and natural history of hen's egg allergy in the first 2 years of life – the EuroPrevall birth cohort study by P. Xepapadaki, A. Fiocchi, L. Grabenhenrich, G Roberts, K E C Grimshaw, A. Fiandor, J. Ignacio Larco, S Sigurdardottir, M. Clausen, L. N G. Papadopoulos, L. Dahdah, A. Mackie, A.B. Sprikkelman, A.A. Schoemaker, R. Dubakiene, I. Butiene, M. L. Kowalski, K. Zeman, S. Gavrili, T. Keil, K. Beyer via Allergy Abstract Background Parents and health staff perceive hen's egg allergy (HEA) as a common food allergy in early childhood but the true incidence is unclear because p... περισσότερα »
Sentinel lymph node biopsy in cN0 squamous cell carcinoma of the lip
: A retrospective study by Erik Mikael Jan Sollamo, Suvi Kristiina Ilmonen, Maria Susanna Virolainen, Sinikka Hilkka Helena Suominen via Head & Neck Abstract Background The purpose of this study was to assess the use of sentinel lymph node biopsy (SLNB) in clinically lymph node–negative (cN0) squamous cell carcinoma (SCC) of the lip deemed high risk for occult nodal metastasis. Methods Twenty-six patients with cT1 to T2 cN0 with SCC of the lip underwent SLNB at a tertiary referral center between January 2001 and March 2012. Initial staging methods were clinical examination only (65.4%)...περισσότερα »
Locoregional failure and smoking persistence are predictors of pulmonary malignancy in patients with HNSCC
Clinical parameters predicting development of pulmonary malignancies in patients treated for head and neck squamous cell carcinoma by Jeevanandham Madana, Grégoire B. Morand, Abdulaziz Alrasheed, Nathalie Gabra, Frédérick Laliberté, Luz Barona–Lleó, Deeke Yolmo, Martin J. Black, Khalil Sultanem, Michael P. Hier via Head & Neck Abstract Background As the locoregional control rates in head and neck squamous cell carcinoma (HNSCC) have increased, these patients may suffer distant metastasis in a higher proportion of cases. Clinicopathological characteristics allowing prediction of high-r...περισσότερα »
Extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma
Influence of by Volkert B. Wreesmann, Nora Katabi, Frank L. Palmer, Pablo H. Montero, Jocelyn C. Migliacci, Mithat Gönen, Diane Carlson, Ian Ganly, Jatin P. Shah, Ronald Ghossein, Snehal G. Patel via Head & Neck ABSTRACT Background An objective definition of clinically relevant extracapsular nodal spread (ECS) in head and neck squamous cell carcinoma (SCC) is unavailable. Methods Pathologic review of 245 pathologically positive oral cavity SCC neck dissection specimens was performed. The presence/absence of ECS, its extent (in millimeters), and multiple nodal and primary tumor risk fa... περισσότερα »
Open versus endoscopic approaches for olfactory neuroblastoma
Comparison of outcomes for open versus endoscopic approaches for olfactory neuroblastoma: A systematic review and individual participant data meta-analysis by Terence S. Fu, Eric Monteiro, Nidal Muhanna, David P. Goldstein, John R. de Almeida via Head & Neck Abstract Background Endoscopic approaches have been adopted as an alternative to craniofacial resection in the surgical management of olfactory neuroblastoma. Methods We conducted a systematic review and meta-analysis using MEDLINE, EMBASE, Cochrane, and CINAHL (2000–2014) to compare outcomes for open versus endoscopic approaches.... περισσότερα »
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