ORL & Medicine,New Articles,November 11th,2015

Role of EGFR Monoclonal Antibodies in the Management of Non–small Cell Lung Cancer

Alexandros G. SfakianakisστοΘεραπείαΠριν από 8 δευτερόλεπτα

Role of EGFR Monoclonal Antibodies in the Management of Non–small Cell Lung Cancer: Dysregulation of epidermal growth factor receptor (EGFR) signaling due to receptor overexpression or activating mutation is associated with cancer cell proliferation, metastasis, and survival. EGFR has become an important therapeutic target for non–small cell lung cancer (NSCLC), and several EGFR-targeted agents, such as tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs), have been developed. The EGFR-TKIs gefitinib, erlotinib, and afatinib have been approved for the treatment of advan...περισσότερα »

Structural Characterization of Alpha-methylacyl-CoA Racemase: Comparative Structural Modeling, Molecular Docking and Dynamic Simulations Studies

Alexandros G. SfakianakisστοΘεραπείαΠριν από 8 δευτερόλεπτα

Structural Characterization of Alpha-methylacyl-CoA Racemase: Comparative Structural Modeling, Molecular Docking and Dynamic Simulations Studies: α-Methylacyl-CoA racemase (AMACR) has recently been reported as a vital solid tumor marker and is an attractive target for designing anti-tumor agents. It is a mitochondrial and peroxisomal enzyme which plays a central role in the oxidation of cholesterol metabolites and branched chain fatty acids. The three dimensional structure of human AMACR is still unknown. In the current study, homology model using Modeller and different modelling se...περισσότερα »

AKT and cytosolic phospholipase A2α form a positive loop in prostate cancer cells

Alexandros G. SfakianakisστοΘεραπείαΠριν από 8 δευτερόλεπτα

AKT and cytosolic phospholipase A2α form a positive loop in prostate cancer cells: Aberrant increase in protein kinase B (AKT) phosphorylation (pAKT), due to a gain-of-function mutation of phosphatidylinositol-3-kinase (PI3K) or loss-of-function mutation or deletion of phosphatase and tensin homolog (PTEN), is a common alteration in prostate cancer and associated with poor prognosis. Cytosolic phospholipase A2α (cPLA2α) is a lipid modifying enzyme by catalyzing the hydrolysis of arachidonic acid from membrane phospholipid. The released arachidonic acid and its metabolites contribute ... περισσότερα »

Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies

Alexandros G. SfakianakisστοΘεραπείαΠριν από 8 δευτερόλεπτα

Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies: Mouse double minute 4 (MDM4) as a member of MDM family, is an oncogene emerging as an imperative negative regulator of p53. Tumor suppressor protein p53 plays a crucial role in cell cycle arrest, apoptosis and homeostasis. It has been reported that frequent inactivation of p53 was observed in numerous human cancers including hematologic malignancies. MDM4, the newly discovered modulator of p53 protein, is frequently amplified in various solid tumors such as cutaneous melanoma, retinoblastoma and hematologic...περισσότερα »

Signal transduction in Acute Myeloid Leukemia – Implications for Novel Therapeutic Concepts.

Alexandros G. SfakianakisστοΘεραπείαΠριν από 8 δευτερόλεπτα

Signal transduction in Acute Myeloid Leukemia – Implications for Novel Therapeutic Concepts.: Acute Myeloid Leukemia (AML) is a highly aggressive clonal hematopoietic disorder that has been managed with largely unchanged treatment protocols for the past decades. Although conventional chemotherapy bears the potential to cure some AML patients, the course of the disease is frequently fatal despite treatment highlighting the need for novel therapeutic concepts. Recent progress in genetic technologies significantly furthered our understanding of the molecular events leading to the disea...περισσότερα »

The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Kidney International from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1M5Ob35 via IFTTT

Heterotopic procedures in mutilating hand injuries: A synopsis of essential reconstructive tools

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Plastic and Reconstructive Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Qhzca0 via IFTTT

Penetrating injury to the gallbladder by a needle fish

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Indian Journal of Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QhzbTG via IFTTT

In Memoriam: Sholom Wacholder, PhD

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 27 δευτερόλεπτα

from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1ShN8hT via IFTTT

The highly alloreactive nature of dual TCR T cells.

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 27 δευτερόλεπτα

The highly alloreactive nature of dual TCR T cells.: Purpose of review: T cells can mediate allograft rejection and graft-versus-host disease (GVHD), but are necessary for tolerance and protective immunity. Identifying T-cell populations differentially responsible for these effects has been a goal in transplant research. This review describes investigation of a small subset of T cells naturally predisposed toward alloreactivity, cells expressing two T-cell receptors (TCRs). Recent findings: Rare peripheral T cells express two [alpha][beta]TCRs. Their impact on T-cell development and ... περισσότερα »

Bortezomib in kidney transplantation.

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 27 δευτερόλεπτα

Bortezomib in kidney transplantation.: Purpose of review: The purpose of this review is to evaluate the effectiveness of bortezomib in the recent literature for the prevention and treatment of kidney transplant rejection. Recent findings: Several studies have analyzed bortezomib alone and in comparison to more traditional immunosuppressive agents during the last 2 years. If administered prior to transplant or soon thereafter, bortezomib appears to lower donor-specific antibody levels and improves graft survival. Its role as a treatment option for antibody-mediated rejection after tra... περισσότερα »

These new articles for The Journal of Clinical Endocrinology & Metabolism are available online

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 40 δευτερόλεπτα

These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ DICER1 Mutations and Differen... περισσότερα »

These new articles for Molecular Endocrinology are available online

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 40 δευτερόλεπτα

These new articles for Molecular Endocrinology are available online ------------------------------ Early Release Molecular Endocrinology ------------------------------ [image: Molecular Endocrinology masthead] ------------------------------ ------------------------------ Molecular Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone Stimulation E. Charmandari, et al. | Molecular ... περισσότερα »

Odorous secretions in anurans: morphological and functional assessment of serous glands as a source of volatile compounds in the skin of the treefrog Hypsiboas pulchellus (Amphibia: Anura: Hylidae)

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 45 δευτερόλεπτα

Abstract Serous (granular or venom) glands occur in the skin of almost all species of adult amphibians, and are thought to be the source of a great diversity of chemical compounds. Despite recent advances in their chemistry, odorous volatile substances are compounds that have received less attention, and until now no study has attempted to associate histological data with the presence of these molecules in amphibians, or in any other vertebrate. Given the recent identification of 40 different volatile compounds from the skin secretions of *H. pulchellus* (a treefrog species that re...περισσότερα »

These new articles for Endocrinology are available online

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 53 δευτερόλεπτα

These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Transgenic chickens over-expressing aromatase have high estrogen levels but maintain a predominantly male phenotype Luke S. Lambeth, et al. | Endocrinology | Nov 10, 2015IG... περισσότερα »

Chemotherapy Delivery Strategies to the Central Nervous System: neither Optional nor Superfluous

Alexandros G. SfakianakisστοΘεραπείαΠριν από 55 δευτερόλεπτα

Chemotherapy Delivery Strategies to the Central Nervous System: neither Optional nor Superfluous: Malignant brain tumors including primary brain tumors (e.g., glioblastoma multiforme) and metastases, are aggressive and lethal entities for the majority of affected patients. Current standard treatments involving combinations of surgery, radiotherapy and systemic chemotherapy offer only modest improvements in survival. Faced with dismal survival, great efforts are deployed to find interesting treatment alternatives. However, the blood-brain barrier (BBB) and the blood-tumor barrier (BT... περισσότερα »

Impact of the novel neonicotinoid insecticide Paichongding on bacterial communities in yellow loam and Huangshi soils

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Impact of the novel neonicotinoid insecticide Paichongding on bacterial communities in yellow loam and Huangshi soils: AbstractInsecticides are widely sprayed in modern agriculture for ensuring the crop yield, which could also lead to contamination and insecticide residue in soils. Paichongding (IPP) is a novel neonicotinoid insecticide and was developed recently in China. Soil bacterial community, diversity, and community composition vary widely depending on environmental factors. As for now, little is known about bacterial species thriving, bacterial community diversity, and stru... περισσότερα »

Neutral community model explains the bacterial community assembly in freshwater lakes

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Neutral community model explains the bacterial community assembly in freshwater lakes: Over the past decade, neutral theory has gained attention and recognition for its capacity to explain bacterial community structure (BCS) in addition to deterministic processes. However, no clear consensus has been drawn so far on their relative importance. In a metacommunity analysis, we explored at the regional and local scale the effects of these processes on the bacterial community assembly within the water column of 49 freshwater lakes. The BCS was assessed using terminal restriction fragmen... περισσότερα »

Dynamic changes in the population structure of Escherichia coli in the Yeongsan River basin of South Korea

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Dynamic changes in the population structure of Escherichia coli in the Yeongsan River basin of South Korea: Although *Escherichia coli* has been used as an indicator to examine fecal contamination of aquatic environment, it also has been reported to become naturalized to secondary habitats, including soil, water and beach sand. A total of 2880 *E. coli* isolates obtained from surface water and sediment samples from the Yeongsan River in 2013 were genotyped by using the horizontal fluorophore-enhanced rep-PCR DNA fingerprinting technique. Although different *E. coli* genotypic group...περισσότερα »

Interaction between two invasive organisms on the European chestnut: does the chestnut blight fungus benefit from the presence of the gall wasp?

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Interaction between two invasive organisms on the European chestnut: does the chestnut blight fungus benefit from the presence of the gall wasp?: The impact of invasive fungal pathogens and pests on trees is often studied individually, thereby omitting possible interactions. In this study the ecological interaction between the chestnut blight fungus *Cryphonectria parasitica* and the chestnut gall wasp *Dryocosmus kuriphilus* was investigated. We determined if abandoned galls could be colonized by *C. parasitica* and thereby act as an entry point and a source of pathogen inoculum. ... περισσότερα »

In Silico Designing and Screening of Antagonists against Cancer Drug Target XIAP

Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα

In Silico Designing and Screening of Antagonists against Cancer Drug Target XIAP: X-linked inhibitor of apoptosis (XIAP) is a member of inhibitor of apoptosis (IAP) family and involved in the suppression of apoptosis in cancer cells. This property makes it a therapeutic target for the cancer therapy. In the present study, we have developed QSAR models using chemical descriptors, fingerprints, principal components, docking energy parameters and similarity-based approach against XIAP. We have achieved correlation (R) of 0.803 with R2 value of 0.645 at 10-fold cross validation using SM... περισσότερα »

MiR-1290 promotes cancer progression by targeting nuclear factor I/X(NFIX)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

in esophageal squamous cell carcinoma (ESCC) via Biomedicine & Pharmacotherapy Publication date: December 2015 *Source:*Biomedicine & Pharmacotherapy, Volume 76 Author(s): Yu Mao, Jia Liu, Dakai Zhang, Baosheng Li The nuclear factor I/X (NFIX) plays important roles in cell differentiation, but its function in cancer is still unclear. Besides, accumulating studies reported the important role of microRNAs (miRNAs) in the regulation of gene expression, among of which, the miR-1290 has been widely reported in various cancers. In this study, we investigated the mechanism through which NFIX... περισσότερα »

Eculizumab use in kidney transplantation.

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 1 ώρα

Eculizumab use in kidney transplantation.: Purpose of review: Eculizumab suppresses the effector functions of the complement system and represents a therapeutic breakthrough for patients with paroxysmal nocturnal hemoglobinuria or atypical hemolytic uremic syndrome (aHUS). Safety monitoring is ongoing; so far, most notable is the expected increase in infection risk with encapsulated organisms. Despite potential applicability in multiple complement-mediated disorders, the off-label use of eculizumab has been limited, mainly by its prohibitive cost. The purpose of this review is to su...περισσότερα »

Alemtuzumab (Campath-1H) experience in kidney transplantation what we have learned; current practices; and scope for the future?.

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 1 ώρα

Alemtuzumab (Campath-1H) experience in kidney transplantation what we have learned; current practices; and scope for the future?.: Purpose of review: Alemtuzumab (Campath) usage as a preconditioning agent in kidney transplantation has gained considerable interest in the recent future. Alemtuzumab is currently available only by special request from Sanofi through its Campath distribution program. It is restricted to transplant programs with prior and continued experience with the agent. There may be a resurgence of interest for the utilization of this agent because of its ease of adm... περισσότερα »

Facial transplantation: worth the risks? A look at evolution of indications over the last decade.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Facial transplantation: worth the risks? A look at evolution of indications over the last decade.: Purpose of review: The first face transplant was performed 10 years ago by Dubernard and his team in France. Since then, surgeons have continued to push the frontiers of vascularized composite allotransplantation and broaden the indications for face transplantation. In this review, we summarize some of the recent successes and failures in facial transplantation from the point of view of indications. Recent findings: Recent literature includes case reports on face transplants in sensitiz... περισσότερα »

Pluripotent stem cell applications for regenerative medicine.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Pluripotent stem cell applications for regenerative medicine.: Purpose of review: In this review, we summarize the current status of clinical trials using therapeutic cells produced from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). We also discuss combined cell and gene therapy via correction of defined mutations in human pluripotent stem cells and provide commentary on key obstacles facing widescale clinical adoption of pluripotent stem cell-based therapy. Recent findings: Initial data suggest that hESC/hiPSC-derived cell products used for re...περισσότερα »

De novo PIK3R1 gain-of-function with recurrent sinopulmonary infections, long-lasting chronic CMV-lymphadenitis and microcephaly

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

De novo PIK3R1 gain-of-function with recurrent sinopulmonary infections, long-lasting chronic CMV-lymphadenitis and microcephaly via http://rss.sciencedirect.com/publication/science/15216616 Publication date: January 2016 *Source:*Clinical Immunology, Volume 162 Author(s): Michaela Kuhlen, Andrea Hönscheid, Loizos Loizou, Schafiq Nabhani, Ute Fischer, Polina Stepensky, Jörg Schaper, Wolfram Klapper, Meinolf Siepermann, Friedhelm Schuster, Roland Meisel, Arndt Borkhardt PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1) gain-of-function has recently been described in patients with ... περισσότερα »

Immunopathology of rejection: do the rules of solid organ apply to vascularized composite allotransplantation?.

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 1 ώρα

Immunopathology of rejection: do the rules of solid organ apply to vascularized composite allotransplantation?.: Purpose of review: As both the number of vascularized composite allotransplants (VCAs) recipients and the duration of their follow-up are limited, immunopathology of VCA rejection remains incompletely understood. VCAs have several immunological peculiarities, which make inaccurate a direct extrapolation of all rules established for solid organs. Recent findings: Despite their bone marrow content, VCA do not induce chimerism in recipient and are therefore not spontaneously ... περισσότερα »

A multimodal multifeature biometric system for human recognition

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

Performance Evaluation of Multimodal Multifeature Authentication System Using KNN Classification: This research proposes a multimodal multifeature biometric system for human recognition using two traits, that is, palmprint and iris. The purpose of this research is to analyse integration of multimodal and multifeature biometric system using feature level fusion to achieve better performance. The main aim of the proposed system is to increase the recognition accuracy using feature level fusion. The features at the feature level fusion are raw biometric data which contains rich informa... περισσότερα »

Parental Self-perception in the Autism Spectrum Disorder Literature

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

Parental Self-perception in the Autism Spectrum Disorder Literature: a Systematic Mixed Studies Review: AbstractParental influence in child development in children with autism spectrum disorder is increasingly recognized as important. The primary aim of this systematic mixed method review was to systematically examine the psychological constructs of competence, control, and self-efficacy in the autism literature to assess their relevance for understanding self-perceptions of parents of children with autism. This review illustrates that self-efficacy can be merged into competence an... περισσότερα »

Identification of early-response genes involved in cadmium resistance in shiitake mushrooms ( Lentinula edodes )

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 1 ώρα

Identification of early-response genes involved in cadmium resistance in shiitake mushrooms ( Lentinula edodes ): AbstractBasidiomycete species accumulate high levels of heavy metals, particularly cadmium (Cd). Heavy metal toxicity has been widely investigated, and different key factors affecting tolerance to heavy metals have been identified in plants and fungi. Nevertheless, molecular insights into different mechanisms of fungi to directly resist reactions with particular heavy metals remain insufficient. As such, early-response genes in basidiomycete fungi must be identified to ... περισσότερα »

Human plasma protein N -glycosylation

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

Human plasma protein N -glycosylation: AbstractGlycosylation is the most abundant and complex protein modification, and can have a profound structural and functional effect on the conjugate. The oligosaccharide fraction is recognized to be involved in multiple biological processes, and to affect proteins physical properties, and has consequentially been labeled a critical quality attribute of biopharmaceuticals. Additionally, due to recent advances in analytical methods and analysis software, glycosylation is targeted in the search for disease biomarkers for early diagnosis and pat... περισσότερα »

Nachruf auf Prof. Dr. Stavros Mentzos (1930–2015)

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

Nachruf auf Prof. Dr. Stavros Mentzos (1930–2015):

„Time is brain“ bei der schubförmigen Multiplen Sklerose

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

„Time is brain“ bei der schubförmigen Multiplen Sklerose: Zusammenfassung HintergrundTrotz der diametral unterschiedlichen Zeitskalen, in denen sich die Krankheitsprozesse und -folgen bei der Multiplen Sklerose (MS) und beim ischämischen Schlaganfall manifestieren, zeigen sich konzeptionelle Parallelen zwischen beiden Erkrankungen, die für das Management der MS richtungsweisend sind: Entzündliche Erkrankungsaktivität und konsekutive Neurodegeneration führen zu potenziell irreversibler Gewebeschädigung und damit zu bleibender Behinderung. Dementsprechend sind eine frühzeitige Detek... περισσότερα »

Comparison of (18)F-FDG PET/CT and PET/MRI in patients with multiple myeloma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Comparison of (18)F-FDG PET/CT and PET/MRI in patients with multiple myeloma.* Am J Nucl Med Mol Imaging. 2015;5(5):469-78 Authors: Sachpekidis C, Hillengass J, Goldschmidt H, Mosebach J, Pan L, Schlemmer HP, Haberkorn U, Dimitrakopoulou-Strauss A Abstract PET/MRI represents a promising hybrid imaging modality with several potential clinical applications. Although PET/MRI seems highly attractive in the diagnostic approach of multiple myeloma (MM), its role has not yet been evaluated. The aims of this prospective study are to evaluate the feasibility of (18)F-FDG PET/MRI in dete...περισσότερα »

Quantitative myocardial blood flow with Rubidium-82 PET: a clinical perspective.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Quantitative myocardial blood flow with Rubidium-82 PET: a clinical perspective.* Am J Nucl Med Mol Imaging. 2015;5(5):457-68 Authors: Hagemann CE, Ghotbi AA, Kjær A, Hasbak P Abstract Positron emission tomography (PET) allows assessment of myocardial blood flow in absolute terms (ml/min/g). Quantification of myocardial blood flow (MBF) and myocardial flow reserve (MFR) extend the scope of conventional semi-quantitative myocardial perfusion imaging (MPI): e.g. in 1) identification of the extent of a multivessel coronary artery disease (CAD) burden, 2) patients with balanced 3-v...περισσότερα »

Monitoring of anti-cancer treatment with (18)F-FDG and (18)F-FLT PET: a comprehensive review of pre-clinical studies.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Monitoring of anti-cancer treatment with (18)F-FDG and (18)F-FLT PET: a comprehensive review of pre-clinical studies.* Am J Nucl Med Mol Imaging. 2015;5(5):431-56 Authors: Jensen MM, Kjaer A Abstract Functional imaging of solid tumors with positron emission tomography (PET) imaging is an evolving field with continuous development of new PET tracers and discovery of new applications for already implemented PET tracers. During treatment of cancer patients, a general challenge is to measure treatment effect early in a treatment course and by that to stratify patients into responde... περισσότερα »

PET studies in epilepsy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*PET studies in epilepsy.* Am J Nucl Med Mol Imaging. 2015;5(5):416-30 Authors: Sarikaya I Abstract Various PET studies, such as measurements of glucose, serotonin and oxygen metabolism, cerebral blood flow and receptor bindings are availabe for epilepsy. (18)Fluoro-2-deoxyglucose ((18)F-FDG) PET imaging of brain glucose metabolism is a well established and widely available technique. Studies have demonstrated that the sensitivity of interictal FDG-PET is higher than interictal SPECT and similar to ictal SPECT for the lateralization and localization of epileptogenic foci in pres...περισσότερα »

Exploiting the fungal highway: development of a novel tool for the in situ isolation of bacteria migrating along fungal mycelium

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Exploiting the fungal highway: development of a novel tool for the in situ isolation of bacteria migrating along fungal mycelium: Fungi and bacteria form various associations that are central to numerous environmental processes. In the so-called fungal highway, bacteria disperse along fungal mycelium. We developed a novel tool for the *in situ* isolation of bacteria moving along fungal hyphae as well as for the recovery of fungi potentially involved in dispersal, both of which are attracted towards a target culture medium. We present the validation and the results of the first *in ... περισσότερα »

The effect of Transcranial Direct Current Stimulation in addition to Tinnitus Retraining Therapy for treatment of chronic tinnitus patients: a study protocol for a double-blind controlled randomised trial

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

The effect of Transcranial Direct Current Stimulation in addition to Tinnitus Retraining Therapy for treatment of chronic tinnitus patients: a study protocol for a double-blind controlled randomised trial: Background: Currently, there still is no treatment that eliminates tinnitus in all patients. Recent studies have shown that Tinnitus Retraining Therapy (TRT) significantly improves quality of life for tinnitus patients. Also, several studies have reported that transcranial Direct Current Stimulation (tDCS) has a positive effect on attention, working memory, long-term memory and oth... περισσότερα »

Ophthalmological complications after administration of local anesthesia in dentistry

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

: a systematic review via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 10 November 2015 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Christos Alamanos, Philipp Raab, Andreea Gamulescu, Michael Behr ObjectiveThe aim of this review was to investigate the association between the occurrence of ocular adverse events and dental local anesthesia, the most plausible anatomical mechanisms, as well as measures that offer patients a restitutio ad integrum.Study DesignThis systematic review adopted a structur... περισσότερα »

Cytotoxicity, Uptake Behaviors, and Oral Absorption of Food Grade Calcium Carbonate Nanomaterials

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Nanomaterials, Vol. 5, Pages 1938-1954: Cytotoxicity, Uptake Behaviors, and Oral Absorption of Food Grade Calcium Carbonate Nanomaterials: Calcium is the most abundant mineral in human body and essential for the formation and maintenance of bones and teeth as well as diverse cellular functions. Calcium carbonate (CaCO3) is widely used as a dietary supplement; however, oral absorption efficiency of CaCO3 is extremely low, which may be overcome by applying nano-sized materials. In this study, we evaluated the efficacy of food grade nano CaCO3 in comparison with that of bulk- or reagent... περισσότερα »

Disruptions of Host Immunity and Inflammation by Giardia Duodenalis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Pathogens, Vol. 4, Pages 764-792: Disruptions of Host Immunity and Inflammation by Giardia Duodenalis: Potential Consequences for Co-Infections in the Gastro-Intestinal Tract: Giardia duodenalis (syn. G. intestinalis, or G. lamblia) is a leading cause of waterborne diarrheal disease that infects hundreds of millions of people annually. Research on Giardia has greatly expanded within the last few years, and our understanding of the pathophysiology and immunology on this parasite is ever increasing. At peak infection, Giardia trophozoites induce pathophysiological responses that culmi... περισσότερα »

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging: [image: 51861eq1.jpg] The goal of this manuscript is to study the hippocampus and hippocampal subfields using MRI. The manuscript describes a protocol for segmenting the hippocampus and five hippocampal substructures: cornu ammonis (CA) 1, CA2/CA3, CA4/dentate gyrus, strata radiatum/lacunosum/moleculare, and subiculum. Abstract The human hippocampus has been broadly studied in the context of memory and normal brain function and its role in different neuro... περισσότερα »

POSITIONAL APNEA IN A 73-YEAR OLD MALE WITH ATRIAL FIBRILLATION

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 1 ώρα

POSITIONAL APNEA IN A 73-YEAR OLD MALE WITH ATRIAL FIBRILLATION: This is the case of a 73-year old male who was diagnosed by the local heart institute with atrial fibrillation. The patient was under outpatient care of both a cardiologist and family doctor.Bed partner interview did not report a history of snoring nor any history of breathing difficulties during the night. However, the patient reported awakening nightly around 0300 to 0400 with the inability to return to sleep because of height- ened arousal. The patient underwent a procedure at the heart institute which induced norm... περισσότερα »

Effects of suvorexant on sleep architecture and power spectral profile in patients with insomnia: analysis of pooled phase-3 data

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 1 ώρα

Effects of suvorexant on sleep architecture and power spectral profile in patients with insomnia: analysis of pooled phase-3 data: • Suvorexant is a first-in-class orexin receptor antagonist for treating insomnia.• Sleep architecture is preserved in insomnia patients taking suvorexant.• The power spectral profile of suvorexant is similar to placebo.

Sleep bruxism in children: sleep studies correlate poorly with parental reports.

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 1 ώρα

Sleep bruxism in children: sleep studies correlate poorly with parental reports.: • Pediatric classification of masticatory muscle activity frequency has lower EMG ranges.• Signs and symptoms of sleep bruxism reported on questionnaires have low to moderate sensitivity.• Parents underreport 56% to 73.7% of bruxism in children. Improved awareness is needed.• Parents who report tooth clenching or grinding in their child are accurate in over 83% of cases.• Children's self-reported craniofacial complaints and dentist-assessed tooth wear were more sensitive to bruxism presence.

Criteria for nap identification in infants and young children using 24-hour actigraphy and agreement with parental diary

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 1 ώρα

Criteria for nap identification in infants and young children using 24-hour actigraphy and agreement with parental diary: • Nap-nap diary/actigraphy agreement improved by using a 9am-5pm time window.• Setting age-specific minimum sleep time limits to identify naps, enhanced agreement.• On a nap-nap basis, parents over-estimated naps in infants but not toddlers.• The average number of daily naps was similar between diary and actigraphy data.

“Insomnia following a mild traumatic brain injury: a missing piece to the work disability puzzle?”

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 1 ώρα

“Insomnia following a mild traumatic brain injury: a missing piece to the work disability puzzle?”: Sleep-wake disturbances are reported by approximately 50% of individuals after a traumatic brain injury (TBI), and insomnia is among the most common sleep disturbances observed in those who have sustained a mild TBI[1, 2]. Although the emergence and evolution of sleep-wake disturbances are still poorly understood, recent evidence has shown that they appear during the acute stage of the injury[3, 4]. Sleep-wake disturbances tend to persist over time[5] and 29% of individuals with TBI s... περισσότερα »

Varicella seroprevalence in healthcare workers in a tertiary hospital

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Varicella seroprevalence in healthcare workers in a tertiary hospital: an audit of cross-sectional data: Background: The seroprevalence of varicella in Southeast Asia is not well described especially in healthcare workers (HCW) in the region. We report the varicella seroprevalence among healthcare workers from a diverse range of countries working in a tertiary care hospital in Singapore. Methods: We audited the results of annual HCW health screening, which included a varicella assay, from the years 2009 to 2014. During this period, there was a change in hospital policy mandating varic... περισσότερα »

High-Level Primary Clarithromycin Resistance of Helicobacter pylori

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

High-Level Primary Clarithromycin Resistance of Helicobacter pylori in Algiers, Algeria: A Prospective Multicenter Molecular Study: Microbial Drug Resistance , Vol. 0, No. 0. Author information Fazia Djennane-Hadibi,1 Mohamed Bachtarzi,1 Karim Layaida,2 Nassima Ali Arous,3 Mhamed Nakmouche,4 Berkane Saadi,2 Mohamed Tazir,1 Nadjia Ramdani-Bouguessa,1 and Christophe Burucoa5 1Laboratoire de Microbiologie Médicale, CHU Mustapha Bacha, Algiers, Algeria . 2Service de Gastroentérologie, CHU Mustapha Bacha, Algiers, Algeria. 3Service de Médecine Interne, EPH Bologhine, Algiers, Algeria. 4S... περισσότερα »

The Sacco Triage Method (STM)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Sacco Triage Method http://www.jumpstarttriage.com/uploads/STM_Factsheet.pdf The Sacco Triage Method (STM) is an evidence based outcome driven triage and resource management system that maximizes expected survivors in consideration of the timing, availability and capability of transport and treatment resources. Based on a simple physiological score (i.e. respiratory rate, pulse, best motor response) that is computed routinely on every trauma patient and that is correlated to survival probability, triage decisions are made in response to the specific type and size of incident, and the...περισσότερα »

The prevalence of primary headache disorders in Nepal: a nationwide population-based study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

The prevalence of primary headache disorders in Nepal: a nationwide population-based study: Background: Headache disorders are among the most prevalent and burdensome global public-health problems. Within countries, health policy depends upon knowledge of health within the local populations, but the South-East Asia Region (SEAR), among WHO’s six world regions, is the only one for which no national headache prevalence data are available. Methods: In a cross-sectional population-based study, adults representative of the Nepali-speaking population aged 18–65 years and living in Nepal wer...περισσότερα »

Transmission in near-infrared optical windows for deep brain imaging

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Transmission in near-infrared optical windows for deep brain imaging: Near-infrared (NIR) radiation has been employed using one- and two-photon excitation of fluorescence imaging at wavelengths 650–950 nm (optical window I) for deep brain imaging; however, longer wavelengths in NIR have been overlooked due to a lack of suitable NIR-low band gap semiconductor imaging detectors and/or femtosecond laser sources. This research introduces three new optical windows in NIR and demonstrates their potential for deep brain tissue imaging. The transmittances are measured in rat brain tissue i... περισσότερα »

Evaluation of carbon nanotubes functionalized with sodium hyaluronate in the inflammatory processes for oral regenerative medicine applications

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα

Evaluation of carbon nanotubes functionalized with sodium hyaluronate in the inflammatory processes for oral regenerative medicine applications: Abstract ObjectivesThe objectives of this study were to assess the effects of hyaluronic acid (HY), multi-walled carbon nanotubes (MWCNT), and MWCNT functionalized with HY (HY-MWCNT) on the resolution of neutrophilic inflammation in the pleural cavity of LPS-challenged mice and to assess the influence of these materials in the inflammatory process of bone repair of tooth sockets of rats. Materials and methodsC57Bl/6 mice were intra-pleu...περισσότερα »

Platelet-rich fibrin

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

: the benefits via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 10 November 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Yuvika Raj Kumar, Sujata Mohanty, Mahesh Verma, Raunaq Reet Kaur, Priyanka Bhatia, Varun Raj Kumar, Zainab Chaudhary Current published data presents confusing results about the effects of platelet-rich fibrin on bone, and there is a need for studies that throw light on its effect. Our main objective therefore was to evaluate (by fractal analysis) osseous regeneration in extraction sockets with and ... περισσότερα »

Osteomyocutaneous peroneal artery perforator flap for reconstruction of the skull base

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Osteomyocutaneous peroneal artery perforator flap for reconstruction of the skull base via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 10 November 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Susana Heredero, Juan Solivera, Blas García, Alicia Dean Figures and tables 1. [image: Peroneal artery perforator flap before trimming. B=fibula, C=thinned and ...] 2. [image: Inset=peroneal artery perforator flap, B=fibula, S=soleus muscle, and O=orbit.] 3. [image: Before and after treatment (published with t... περισσότερα »

Primary Ewing Family of Tumors of the Jaw & Tumors of Extragnathic sites

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

has a better Prognosis compared to Tumors of Extragnathic sites via Oral and Maxillofacial Surgery Publication date: Available online 10 November 2015 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Adepitan A. Owosho, Eugene Ko, Haley I. Rosenberg, SaeHee K. Yom, Cristina R. Antonescu, Joseph M. Huryn, Cherry L. Estilo ObjectivePrimary Ewing sarcoma of the jaw is rare. The aim of this study is to describe new cases of primary Ewing sarcoma of the jaw, investigating reported prognostic factors of Ewing sarcoma in this series as well as treatment outcome.Patients and Metho... περισσότερα »

Secondary Squamous Cell Carcinoma Around a Dental Implant

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Histopathological Features of Secondary Squamous Cell Carcinoma Around a Dental Implant in the Mandible After Chemoradiotherapy: A Case Report with a Clinicopathological Review via Oral and Maxillofacial Surgery Publication date: Available online 10 November 2015 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Yoshiki Nariai, Takahiro Kanno, Joji Sekine Oral squamous cell carcinoma (OSCC) around a dental implant is a rare pathological condition. We present a case of recurrent OSCC surrounding a dental implant along with histopathological findings and a literature review o... περισσότερα »

Intermaxillary Fixation for Simple Pediatric Mandible Fractures

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

An Alternative Method of via Oral and Maxillofacial Surgery Publication date: Available online 10 November 2015 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Scott J. Farber, Dennis C. Nguyen, Alan A. Harvey, Kamlesh B. Patel PurposeMandible fractures represent a significant portion of facial fractures in the pediatric population. Pediatric mandibles differ than their adult counterparts due to the presence of mixed dentition. Avoidance of injury to developing tooth follicles is critical. Simple mandible fractures can be treated with intermaxillary fixation (IMF) using ... περισσότερα »

Guided Bone Regeneration using Demineralized Dentin Matrix

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Long-term Follow up of via Oral and Maxillofacial Surgery Publication date: Available online 10 November 2015 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Young-Kyun Kim, Jong-Ho Lee, In-Woong Um, Woo-Jin Cho ObjectiveThis case report reviews the long term clinical outcomes of AutoBT (demineralized dentin matrix) of five study samples that were first reported in 2010.MethodCone-beam computerized tomography was used to measure the height and width of a graft to compare the change in bone area between immediate post operation and final follow up after an average of 5 ye... περισσότερα »

Prise en charge d’une canine incluse

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Prise en charge d’une canine incluse via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 10 November 2015 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): P.-Y. Blanchard, J.-B. Kerbrat, C. Paulus, F. Saint-Pierre La Société française de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale (SFSCMFCO) et la Société médicale d’orthopédie dento-maxillo-faciale ont élaboré en juillet 2015 une nouvelle recommandation de bonnes pratiques portant sur la conduite à tenir devant...περισσότερα »

HNO, Vol. 63, Issue 11 - New Issue Alert

Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 1 ώρα

If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 11/11/2015 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *HNO*. Volume 63 Number 11 is now available online. Important news Papers, the reference manager, for iPhone and iPad now totally free Full functionality, no in-app purchases or small print. Find, organize, read and share the research materials you care about, anytime, anywhere. Download today: http://papersapp.com/ios. » Learn more In this issue Einführun... περισσότερα »

An update on peripheral ossifying fibroma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

An update on peripheral ossifying fibroma: case report and literature review: AbstractThe purpose of the present article was to present a clinical case of an 11-year-old girl with peripheral ossifying fibroma (POF). Additionally, after performing a literature review, we identified clinical information that occurs more frequently in association with POF, such evidence would help professionals in yielding a specific diagnosis and tailor a more specific therapeutic approach with the objective to decrease morbidities’ associated with POF. This lesion represents the third most common l... περισσότερα »

Microcystic adnexal carcinoma of the scalp

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Longtime undetected microcystic adnexal carcinoma of the scalp: considerations and implications: Abstract BackgroundMicrocystic adnexal carcinomas (MACs) are slow-growing and often asymptomatic malignant skin tumours that usually develop on the facial skin and may reach considerable size. We present an uncommon case of MAC arising on the hair-bearing scalp and discuss our experiences and considerations. Case reportA 58-year-old female was admitted with a histopathologically secured diagnosis of MAC of the temporal and occipital regions that had expanded to 10 × 12 cm. Magnetic r... περισσότερα »

Association between genetic variants of the clock gene and obesity and sleep duration

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 2 ώρες

Abstract Obesity is a multifactorial disease caused by the interaction of genetic and environmental factors related to lifestyle aspects. It has been shown that reduced sleep is associated with increased body mass index (BMI). Circadian Locomotor Output Cycles Kaput (*CLOCK*) gene variants have also been associated with obesity. The objective of this mini-review was to discuss the available literature related to *CLOCK* gene variants associated with adiposity and sleep duration in humans. In total, 16 articles complied with the terms of the search that reported *CLOCK* variants as... περισσότερα »

Establishment of a new pull-out strength testing method to quantify early osseointegration

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

—an experimental pilot study via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 10 November 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): J. Nonhoff, T. Moest, Christian Martin Schmitt, T. Weisel, S. Bauer, K.A. Schlegel ObjectivesThe animal study aims to evaluate a new experimental model for measuring sole the influence of the surface characteristics independent from implant macro-design on the level of osseointegration by registering the pull-out strength needed for removal of experimental devices with differen...περισσότερα »

Does the piezoelectric surgical technique produce fewer postoperative sequelae after lower third molar surgery than conventional rotary instruments? A systematic review and meta analysis

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

Does the piezoelectric surgical technique produce fewer postoperative sequelae after lower third molar surgery than conventional rotary instruments? A systematic review and meta analysis: A systematic review and meta-analysis was conducted to answer the clinical question “Does the piezoelectric surgical technique produce fewer postoperative sequelae after lower third molar surgery than conventional rotary instruments?” A systematic and electronic search of several databases with specific key words, a reference search, and a manual search were performed from respective dates of incep... περισσότερα »

Correlative micro-Raman/EPMA analysis of the hydraulic calcium silicate cement interface with dentin

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

Correlative micro-Raman/EPMA analysis of the hydraulic calcium silicate cement interface with dentin: Abstract ObjectivesThis study aims to characterize the chemical interplay of hydraulic calcium silicate cements at dentin. Materials and methodsClass I cavities were prepared in non-carious human third molars and filled with Biodentine (Septodont) or ProRoot MTA (Dentsply). After 1-day, 1-week, and 1-month Dulbecco’s phosphate-buffered saline (DPBS) storage, the specimens were cross-sectioned perpendicular to the cement-dentin interface. The interfaces were evaluated using micr...περισσότερα »

Osteomyocutaneous peroneal artery perforator flap for reconstruction of the skull base

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Osteomyocutaneous peroneal artery perforator flap for reconstruction of the skull base: Craniofacial resection for the treatment of malignant disease may result in complex 3-dimensional defects of the skull base. Microvascular free flaps are a good way to isolate the central nervous system from the upper aerodigestive tract, and restore the normal appearances and contours of the bony and soft tissues.1 Although the rectus abdominis myocutaneous flap has been the workhorse for microvascular reconstructions of the skull base to date, some surgeons now use anterolateral free flaps.2

Involvement of oral tissues by AL amyloidosis: a literature review and report of eight new cases

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες

Involvement of oral tissues by AL amyloidosis: a literature review and report of eight new cases: Abstract ObjectiveAmyloidosis is a term used to describe a group of diseases in which there is an extracellular deposition of amorphous fibrillar proteins known as amyloid. The aim of this study was to present clinicopathological data from eight oral amyloidosis-affected patients and a deep review of the literature about the disease. Materials and methodsA retrospective study was conducted based on the records of oral amyloidosis-affected patients diagnosed in our institution betwe...περισσότερα »

Evaluation of the mandibular volume and correlating variables in patients affected by unilateral and bilateral cleft lip and palate: a cone-beam computed tomography study

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες

Evaluation of the mandibular volume and correlating variables in patients affected by unilateral and bilateral cleft lip and palate: a cone-beam computed tomography study: Abstract ObjectivesThe aims of the present study were to evaluate the mandibular volume in patients affected by unilateral (UCLP) and bilateral cleft lip and palate (BCLP) and to compare the findings with a well-matched normal occlusion sample without cleft. Materials and methodsThe study sample consisted of 66 patients divided into UCLP (24 patients; mean age, 14.46 ± 3.24 years), BCLP (17 patients; mean ag... περισσότερα »

The systemic alendronate treatment for 60 days did not change the enamel of rats regarding the susceptibility to acids

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

Enamel permeability and resistance to acid challenges after systemic use of sodium alendronate: a study in rat teeth via Clinical Oral Investigations AbstractObjectivesTo evaluate the enamel resistance and permeability of rat teeth to acid challenges after systemic use of sodium alendronate. Materials and methodsEighteen Wistar rats (36 teeth), aged 36–42 days (200–230 g), were assigned into two groups: alendronate group (*n* = 20 teeth), which received two weekly doses of 1 mg/kg of alendronate, via gavage; and a non-alendronate group (*n* = 16 teeth), which received only distilled w...περισσότερα »

Can apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs?

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

Can apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs?: Abstract ObjectivesThe aim of this study was to investigate whether apical periodontitis (AP) could cause systemic cytokine elevation and pathological changes in remote organs in an experimental animal model. Materials and methodsAP was induced in 36 Sprague Dawley (SD) rats. Serum levels of C-reactive protein (CRP), interleukin 2 (IL-2), and interleukin 6 (IL-6) were measured by enzyme-linked immunosorbent assays at different time intervals (0, 6, 12, 2... περισσότερα »

Antibacterial and antiplaque efficacy of a commercially available octenidine-containing mouthrinse

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

Antibacterial and antiplaque efficacy of a commercially available octenidine-containing mouthrinse: Abstract ObjectivesThe purpose of this clinical study was to determine the antibacterial and antiplaque efficacy of a recently introduced octenidine-containing mouthrinse (Octenidol®) in comparison with established antiseptic mouthrinses. Materials and methodsIn a 4-day plaque-regrowth study employing a four-replicate cross-over design, a 0.1 % octenidine mouthrinse (Octenidol®/OCT-MR) was compared with a 0.12 % chlorhexidine mouthrinse (Paroex®/CHX-MR), an essential oil mouthrin... περισσότερα »

The effect of fluoride varnishes on caries lesions

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

The effect of fluoride varnishes on caries lesions: an in vitro investigation: Abstract ObjectivesThe purpose of this study was to investigate the effect of five commercially available fluoride varnishes (FV) on caries lesions. Materials and methodsNinety bovine enamel specimens were assigned to five varnish groups (*n* = 18). Early caries lesions were created in the specimens and characterized using Vickers surface microhardness number (VHN). FV was applied to each group of specimens. Immediately afterwards, 7.5 ml of artificial saliva (AS) were pipetted over each group of spe... περισσότερα »

Positioning handle and occlusal locks for the Teeth-in-a-Day protocol

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

Positioning handle and occlusal locks for the Teeth-in-a-Day protocol via The Journal of Prosthetic Dentistry Publication date: Available online 10 November 2015 *Source:*The Journal of Prosthetic Dentistry Author(s): Thomas J. Balshi, Glenn J. Wolfinger, Stephen F. Balshi Positioning handles and occlusal locks have evolved as improvements to the Teeth-in-a-Day protocol. These improvements have enabled a more accurate alignment of the removable dental prosthesis during the conversion prosthesis technique. These improvements can be easily incorporated through computer-aided design and co...περισσότερα »

Enamel matrix protein derivative and/or synthetic bone substitute for the treatment of mandibular class II buccal furcation defects. A 12-month randomized clinical trial

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες

. A 12-month randomized clinical trial: Abstract ObjectiveThis study aims to clinically evaluate the treatment of mandibular class II furcation defects with enamel matrix derivative (EMD) and/or a bone substitute graft made of β-tricalcium phosphate/hydroxyapatite (βTCP/HA). Materials and methodsForty-one patients, presenting a mandibular class II buccal furcation defect, probing pocket depth (PPD) ≥4 mm and bleeding on probing, were included. They were randomly assigned to the groups: 1—EMD ( *n* = 13); 2—βTCP/HA (*n* = 14); 3—EMD + βTCP/HA (*n* = 14). Plaque index (PI), gingiv...περισσότερα »

The fruit fly, Drosophila melanogaster

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 2 ώρες

Auditory system of fruit flies via Hearing Research Publication date: Available online 10 November 2015 *Source:*Hearing Research Author(s): Yuki Ishikawa, Azusa Kamikouchi [image: Drosophila melanogaster - side (aka).jpg] The fruit fly, Drosophila melanogaster, is an invaluable model for auditory research. Advantages of using the fruit fly include its stereotyped behavior in response to a particular sound, and the availability of molecular-genetic tools to manipulate gene expression and cellular activity. Although the receiver type in fruit flies differs from that in mammals, the aud... περισσότερα »

Early Cortical Representations of Speech Signals

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 2 ώρες

Attentional Modulation of Informational Masking on Early Cortical Representations of Speech Signals via Hearing Research Publication date: Available online 10 November 2015 *Source:*Hearing Research Author(s): Changxin Zhang, Stephen R. Arnott, Cristina Rabaglia, Meital Avivi-Reich, James Qi, Xihong Wu, Liang Li, Bruce A. Schneider To recognize speech in a noisy auditory scene, listeners need to perceptually segregate the target talker’s voice from other competing sounds (stream segregation). A number of studies have suggested that the attentional demands placed on listeners increase a...περισσότερα »

Animal models of tinnitus

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 2 ώρες

Animal models of tinnitus via Hearing Research Publication date: Available online 10 November 2015 *Source:*Hearing Research Author(s): Thomas J. Brozoski, Carol A. Bauer Presented is a thematic review of animal tinnitus models from a functional perspective. Chronic tinnitus is a persistent subjective sound sensation, emergent typically after hearing loss. Although the sensation is experientially simple, it appears to have central a nervous system substrate of unexpected complexity that includes areas outside of those classically defined as auditory. Over the past 27 years animal model...περισσότερα »

Parkinson's disease : Motion analysis of axial rotation and gait stability during turning

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 2 ώρες

in people with Parkinson's disease via Gait & Posture Publication date: Available online 9 November 2015 *Source:*Gait & Posture Author(s): Wen-Chieh Yang, Wei-Li Hsu, Ruey-Meei Wu, Tung-Wu Lu, Kwan-Hwa Lin BackgroundAxial rigidity and postural instability in people with Parkinson's disease (PD) may contribute to turning difficulty. This study examined the rotation of axial segments and gait instability during turning in people with PD.MethodsThirteen PD and twelve age-matched healthy adults were recruited. Participants performed the timed Up-and-Go test and were recorded by a 3D mot... περισσότερα »

Force-plate posturography in the assessment of postural instability

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 2 ώρες

The use of via Gait & Posture Publication date: Available online 10 November 2015 *Source:*Gait & Posture Author(s): Janusz W. Błaszczyk Force-plate posturography is a simple method that is commonly used in the contemporary laboratory and clinic to assess postural control. Despite the obvious advantages and popularity of the method, universal standards for posturographic tests have not been developed thus far: most postural assessments are based on the standard spatiotemporal metrics of the center-of-foot pressure (COP) recorded during quiet stance. Unfortunately, the standard COP ch... περισσότερα »

Children with developmental coordination disorder: Direction-specific impairment of stability limits and falls

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 2 ώρες

Direction-specific impairment of stability limits and falls in children with developmental coordination disorder: Implications for rehabilitation via Gait & Posture Publication date: Available online 10 November 2015 *Source:*Gait & Posture Author(s): Shirley S.M. Fong, Shamay S.M. Ng, Louisa M.Y. Chung, W.Y. Ki, Lina P.Y. Chow, Duncan J. Macfarlane Limits of stability (LOS) is an important yet under-examined postural control ability in children with developmental coordination disorder (DCD). This study aimed to (1) compare the LOS and fall frequencies of children with and without DCD,... περισσότερα »

Foot sole skin vibration perceptual thresholds

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 2 ώρες

are elevated in a standing posture compared to sitting via Gait & Posture Publication date: Available online 10 November 2015 *Source:*Gait & Posture Author(s): Robyn L. Mildren, Nicholas D.J. Strzalkowski, Leah R. Bent Foot sole sensitivity is commonly assessed while individuals are seated or prone; however the primary role of foot sole cutaneous feedback is for the control of upright stance and gait. The aim of this study was to compare vibration perceptual thresholds across the foot sole between sitting and standing postures. Vibration perceptual thresholds were measured in sitting ...περισσότερα »

Acoustic Immittance Measures: Basic and Advanced Practice.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 2 ώρες

Acoustic Immittance Measures: Basic and Advanced Practice.

American Sleep and Breathing Academy “Study Club” redefines successful dental sleep medicine weekend courses!

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 2 ώρες

American Sleep and Breathing Academy “Study Club” redefines successful dental sleep medicine weekend courses!: November 11th 2015, from the ASBA PEORIA, Arizona, November 11th 2015 – One of the fastest growing areas in dentistry, dental sleep medicine is also a source of annoyance and deflated expectations for a lot of Dentists who have invested in courses and equipment , only to leave with no clear plan of how to incorporate dental sleep into their practice. The American Sleep and Breathing Academy “ASBA” Study club seminars redefine what a successful dental sleep weekend course ... περισσότερα »

American Sleep and Breathing Academy “Study Club” redefines successful dental sleep medicine weekend courses!

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 2 ώρες

November 11th 2015, from the ASBA PEORIA, Arizona, November 11th 2015 – One of the fastest growing areas in dentistry, dental sleep medicine is also a source of annoyance and deflated expectations for a lot of Dentists who have invested in courses and equipment , only to leave with no clear plan of how to incorporate dental sleep into their practice. The American Sleep and Breathing Academy "ASBA" Study club seminars redefine what a successful dental sleep weekend course is. The Study club is led by ASBA Diplomates "DASBA" who concentrate on helping attendees learn the skills to... περισσότερα »

Resin-composites incorporating novel matrices

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

Development of viscoelastic stability of via Dental Materials Publication date: Available online 10 November 2015 *Source:*Dental Materials Author(s): Khold Al-Ahdal, Nick Silikas, David C. Watts ObjectivesTo study the effect of resin matrix and maturation time (1 and 24h) on the creep deformation of resin-composites, two of which have matrix-forming monomers that are either bis-GMA free or have an ormocer structure between the CC groups.MethodsFive resin-composites: four commercial and one experimental were investigated. Six specimens were prepared for each material and were divided ... περισσότερα »

Confirmation of an anatomic variation of the recurrent laryngeal nerve at site of entry into the larynx in Chinese population

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

Confirmation of an anatomic variation of the recurrent laryngeal nerve at site of entry into the larynx in Chinese population: This study was aimed at analyzing the frequency of the newly reported variation and the frequency of postoperative palsy associated with three different kinds of known variations. Abstract*Objective* This study was aimed at analyzing the frequency of the newly reported variation and the frequency of postoperative palsy associated with three different kinds of known variations. *Methods* We conducted a retrospective study on the data of 2068 consecutive Chine... περισσότερα »

Immediate obturator stabilization (ISO) in severely atrophic edentulous maxilla: suspension wiring technique

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 2 ώρες

Immediate obturator stabilization (ISO) in severely atrophic edentulous maxilla: suspension wiring technique: The treatment of malignant neoplasms of the hard palate comprises radical surgical resection. Defects of the maxillary sinus, hard palate and upper alveolar ridge may leave the patient with significant postoperative speech and swallowing problems [1]. Several maxillectomy defect classifications have been developed to ascertain the most effective means of rehabilitation for each type of defect . The defects can be repaired using fasciocutaneous or bone-containing free flaps o... περισσότερα »

Voice Quality and Reduction of Breath Airflow in the Soprano Voice

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 2 ώρες

Interactive Augmentation of via ScienceDirect Publication: Journal of Voice Publication date: Available online 10 November 2015 *Source:*Journal of Voice Author(s): Martin Rothenberg, Harm K. Schutte In 1985, at a conference sponsored by the National Institutes of Health, Martin Rothenberg first described a form of nonlinear source-tract acoustic interaction mechanism by which some sopranos, singing in their high range, can use to reduce the total airflow, to allow holding the note longer, and simultaneously enrich the quality of the voice, without straining the voice. (M. Rothenberg,... περισσότερα »

Vibrato Rate and Extent in College Music Majors

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 2 ώρες

: A Multicenter Study via ScienceDirect Publication: Journal of Voice Publication date: Available online 10 November 2015 *Source:*Journal of Voice Author(s): John Nix, Nicholas Perna, Kimberly James, Sheila Allen ObjectivesTo examine differences in vibrato rate and extent according to vowel, production type, gender, voice type, and vocal training.Study designCross-sectional.MethodsFour collegiate voice teachers used a common protocol to gather data on habitual, best classical, and nonvibrato singing production of five vowels in 78 male and female vocal majors. Subject age, gender, voi...περισσότερα »

Expiratory Muscle Strength Training on Voice

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 2 ώρες

The Effects of Expiratory Muscle Strength Training on Voice and Associated Factors in Medical Professionals With Voice Disorders via ScienceDirect Publication: Journal of Voice Publication date: Available online 10 November 2015 *Source:*Journal of Voice Author(s): Yuan-Ching Tsai, ShihWei Huang, Wei-Chun Che, Yi-Ching Huang, Tsan-Hon Liou, Yu-Chi Kuo ObjectivesThis research used expiratory muscle strength training to explore the factors relevant to medical professionals with voice disorders. The maximal expiratory pressure (MEP) improved, which is measured by the maximal contracting f... περισσότερα »

Semioccluded Postures in Subjects With Different Voice Conditions

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 2 ώρες

Air Pressure and Contact Quotient Measures During Different via ScienceDirect Publication: Journal of Voice Publication date: Available online 10 November 2015 *Source:*Journal of Voice Author(s): Marco Guzmán, Christian Castro, Sofia Madrid, Christian Olavarria, Miguel Leiva, Daniel Muñoz, Elizabeth Jaramillo, Anne-Maria Laukkanen ObjectiveThe purpose of this study was to investigate the effect of phonation into tubes in air and tubes submerged in water on air pressure variables and vocal fold adduction in subjects with different voice conditions.MethodsForty-five participants repres...περισσότερα »

Effect of Rapid Maxillary Expansion on Voice

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 2 ώρες

Effect of Rapid Maxillary Expansion on Voice via ScienceDirect Publication: Journal of Voice Publication date: Available online 10 November 2015 *Source:*Journal of Voice Author(s): Anthony T. Macari, Georges Ziade, Mohannad Khandakji, Hani Tamim, Abdul-Latif Hamdan ObjectiveThe purpose of this investigation is to evaluate the effect of rapid maxillary expansion (RME) on the fundamental frequency (F0) and formant frequencies F1–F4.Study DesignCross-sectional study.Materials and MethodsA total of 14 consecutive patients between the ages of 9.6 years and 15 years with a constricted maxil... περισσότερα »

Swallowing outcome measures in head and neck cancer

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 2 ώρες

– How do they compare? via ScienceDirect Publication: Oral Oncology Publication date: Available online 10 November 2015 *Source:*Oral Oncology Author(s): A. Pedersen, Janet Wilson, Elaine McColl, Paul Carding, Jo Patterson ObjectivesDysphagia is a common and debilitating side effect of chemoradiotherapy. Assessment is difficult; swallowing is multifactorial and studies choose from a range of dysphagia assessments. This study intended to investigate the relationship between swallowing assessments of dysphagia in a cohort of patients and to evaluate whether clinical swallowing measures... περισσότερα »

Swallowing outcome measures in HNC

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

head and neck cancer – How do they compare? via ScienceDirect Publication: Oral Oncology Publication date: Available online 10 November 2015 *Source:*Oral Oncology Author(s): A. Pedersen, Janet Wilson, Elaine McColl, Paul Carding, Jo Patterson ObjectivesDysphagia is a common and debilitating side effect of chemoradiotherapy. Assessment is difficult; swallowing is multifactorial and studies choose from a range of dysphagia assessments. This study intended to investigate the relationship between swallowing assessments of dysphagia in a cohort of patients and to evaluate whether clinical ...περισσότερα »

The Endoscopic Management of Subglottic Stenosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Technique for Improved Safety in the Endoscopic Management of Subglottic Stenosis: Subglottic stenosis is an abnormal narrowing of the upper airway. Acquired subglottic stenosis may result from mechanical trauma, laryngopharyngeal reflux, and autoimmune disorders including granulomatosis with polyangiitis (Wegener’s granulomatosis) as well as relapsing polychondritis. Alternatively, when there is no clear etiology, subglottic stenosis is categorized as idiopathic. [1] , [2] Traditionally management includes surgical intervention with open resection or endoscopic management. [3] Dire...περισσότερα »

Type IV Congenital Laryngeal Web

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Type IV Congenital Laryngeal Web: Case Report and 15 Year Follow up: A five day old patient with mild VACTERL syndrome had repair of a Type IV congenital laryngeal web with successful decanulation 76days later. Voice and respiratory outcome is good with follow up 15years later. This case presents a rare clinical finding of a type IV laryngeal web successfully repaired with a keel and subsequent long term follow up during an era when it was suggested that repair be delayed until 18months of age at the earliest.

An anatomic variation of the recurrent laryngeal nerve at site of entry into the larynx

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Confirmation of an anatomic variation of the recurrent laryngeal nerve at site of entry into the larynx in Chinese population: This study was aimed at analyzing the frequency of the newly reported variation and the frequency of postoperative palsy associated with three different kinds of known variations. Abstract*Objective* This study was aimed at analyzing the frequency of the newly reported variation and the frequency of postoperative palsy associated with three different kinds of known variations. *Methods* We conducted a retrospective study on the data of 2068 consecutive Chin... περισσότερα »

Immediate obturator stabilization (ISO) in severely atrophic edentulous maxilla: suspension wiring technique

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Immediate obturator stabilization (ISO) in severely atrophic edentulous maxilla: suspension wiring technique: The treatment of malignant neoplasms of the hard palate comprises radical surgical resection. Defects of the maxillary sinus, hard palate and upper alveolar ridge may leave the patient with significant postoperative speech and swallowing problems [1]. Several maxillectomy defect classifications have been developed to ascertain the most effective means of rehabilitation for each type of defect . The defects can be repaired using fasciocutaneous or bone-containing free flaps o... περισσότερα »

Efficacy of balloon dilation in the treatment of symptomatic eustachian tube dysfunction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Efficacy of balloon dilation in the treatment of symptomatic eustachian tube dysfunction: One year follow-up study: Eustachian tube balloon dilation (ETBD) has been recently described as feasible treatment for patients with refractory Eustachian tube dysfunction (ETD). The aim of this study was to evaluate the efficacy of ETBD in the treatment of symptomatic Eustachian tube dysfunction (SETD) by subjective and objective analysis.

Spontaneous resolution of a petrous apex cholesterol granuloma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Spontaneous resolution of a petrous apex cholesterol granuloma: Cholesterol granuloma is the most common primary lesion of the petrous apex. Management of petrous apex cholesterol granuloma has evolved in recent years from primary surgical treatment to conservative observation. In this article, a case of spontaneous resolution of a petrous apex cholesterol granuloma is described. To the authors’ knowledge, this is the first known report of spontaneous involution of a petrous apex cholesterol granuloma. Radiographic differential diagnosis of petrous apex lesions and the natural histo... περισσότερα »

The triticeous cartilage is a small ovoid cartilaginous structure variably present as a component of the laryngeal skeleton

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Triticeous Cartilage CT Imaging Characteristics, Prevalence, Extent, and Distribution of Ossification: Objective The triticeous cartilage is a small ovoid cartilaginous structure variably present as a component of the laryngeal skeleton. This structure has received scant attention in the literature and has yet to be described adequately on cross-sectional imaging. Study Design and Setting Retrospective study in a tertiary medical center. Subjects and Methods We investigated triticeous cartilage prevalence in a large population utilizing computed tomography images. The cases of all... περισσότερα »

Transoral Diverticulotomy for Zenker's Diverticulum

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Short-term Quality-of-Life Outcomes following Transoral Diverticulotomy for Zenker's Diverticulum: A Prospective Single-Group Study: Objective To prospectively analyze quality-of-life outcomes following transoral diverticulotomy with cricopharyngeal myotomy (DCPM) for Zenker’s diverticulum (ZD). Study Design Prospective single-group study. Settings Tertiary academic institution. Subjects and Methods A prospective multicenter study performed from January 1, 2012, to July 1, 2014, included 18 patients presenting with ZD undergoing DCPM. Standardized questionnaires—including the 10...περισσότερα »

Potential Benefits of Combination Therapy as Primary Treatment for Sudden Sensorineural Hearing Loss

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Potential Benefits of Combination Therapy as Primary Treatment for Sudden Sensorineural Hearing Loss: Objective We analyzed the effectiveness of combination therapy (CT) for idiopathic sudden sensorineural hearing loss (ISSNHL) and the utility of intratympanic dexamethasone injection (ITDI) reapplication as salvage treatment for ISSNHL refractory to CT. Study Design Case series with chart review. Setting Academic university hospital. Subjects and Methods We reviewed 229 patients with ISSNHL and divided these patients into 2 groups according to treatment: systemic steroid therapy...περισσότερα »

Amblyaudia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

A Brief Overview of Amblyaudia [image: Download] *Download as PDF* (Size:231KB) HTML XML PP. 927-933 *DOI: *10.4236/health.2015.78110 *Author(s)* Leave a comment RaeLynn J. Lamminen, Daniel Houlihan* Affiliation(s) Minnesota State University, Mankato, USA. ABSTRACT Amblyaudia, a recent subcategory of auditory processing disorder, is characterized by asymmetrical auditory processing of an individual’s ears. Amblyaudia can result in speech comprehension difficulties, reading difficulties, information processing deficits, and inattention. These difficulties can be mistakenly at... περισσότερα »

Amblyaudia: Review of Pathophysiology, Clinical Presentation, and Treatment of a New Diagnosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Amblyaudia: Review of Pathophysiology, Clinical Presentation, and Treatment of a New Diagnosis: Objective Similar to amblyopia in the visual system, "amblyaudia" is a term used to describe persistent hearing difficulty experienced by individuals with a history of asymmetric hearing loss (AHL) during a critical window of brain development. Few clinical reports have described this phenomenon and its consequent effects on central auditory processing. We aim to (1) define the concept of amblyaudia and (2) review contemporary research on its pathophysiology and emerging clinical relevanc...περισσότερα »

Quality Improvement in Otolaryngology Residency: Survey of Program Directors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Quality Improvement in Otolaryngology Residency: Survey of Program Directors: Objectives The Clinical Learning Environment Review focuses on the responsibility of the sponsoring institution for quality and patient safety. Very little information is known regarding the status of quality improvement (QI) education during otolaryngology training. The purpose of this survey is to evaluate the extent of resident and faculty participation in QI and identify opportunities for both resident curriculum and faculty development. Study Design Cross-sectional survey Subjects and Methods A 15-... περισσότερα »

Low-Density Lipoprotein Uptake Demonstrates a Hepatocyte Phenotype in the Dog, but Is Nonspecific

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες

Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1RNenB0 via IFTTT

Phosphatidic Acid Improves Reprogramming to Pluripotency by Reducing Apoptosis

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες

Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1NJj13S via IFTTT

Low-Density Lipoprotein Uptake Demonstrates a Hepatocyte Phenotype in the Dog, but Is Nonspecific

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες

Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1RNenB0 via IFTTT

Phosphatidic Acid Improves Reprogramming to Pluripotency by Reducing Apoptosis

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες

Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1NJj13S via IFTTT

Author Self-Citation in the Otolaryngology Literature: A Pilot Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Author Self-Citation in the Otolaryngology Literature: A Pilot Study: Objective To determine the prevalence of author self-citation in the field of otolaryngology. Study Design and Setting A retrospective review of bibliographic references in 5 otolaryngology journals. Subjects and Methods Five high-impact otolaryngology journals were reviewed over a 3-month period between January and March 2014 to identify the pattern of author self-citations. Data included study type, otolaryngology topic, authorship, total citations, author self-citations, and country of origin. Results Near... περισσότερα »

European Radiology, Vol. 25, Issue 12 - New Issue Alert

Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 9 ώρες

If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 11/10/2015 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *European Radiology*. Volume 25 Number 12 is now available online. Important news Papers, the reference manager, for iPhone and iPad now totally free Full functionality, no in-app purchases or small print. Find, organize, read and share the research materials you care about, anytime, anywhere. Download today: http://papersapp.com/ios. » Learn more In this ... περισσότερα »

Journal of the Association for Research in Otolaryngology, Vol. 16, Issue 6 - New Issue Alert

Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 9 ώρες

If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 11/11/2015 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Journal of the Association for Research in Otolaryngology*. Volume 16 Number 6 is now available online. Important news Papers, the reference manager, for iPhone and iPad now totally free Full functionality, no in-app purchases or small print. Find, organize, read and share the research materials you care about, anytime, anywhere. Download today: http://pap... περισσότερα »

FeedaMail: Microbiology via ola Kala on Inoreader

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 10 ώρες

[image: feedamail.com] Microbiology via ola Kala on Inoreader (Sponsor this newsletter) Molecular armory or niche factors: virulence determinants of Corynebacterium species For successful colonization of a host, pathogenic bacteria are equipped with a plethora of proteins and other components, often designated as virulence factors. However, many of these factors are involved in general adaptation to ecological niches rather than being specific for interaction of a bacterial pathogen with a distinct host. Therefore, a designation of these components as niche factors was proposed... περισσότερα »

Journal of Mammary Gland Biology and Neoplasia, Vol. 20, Issue 3 - New Issue Alert

Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 14 ώρες

If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 11/10/2015 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Journal of Mammary Gland Biology and Neoplasia*. Volume 20 Number 3-4 is now available online. Important news Papers, the reference manager, for iPhone and iPad now totally free Full functionality, no in-app purchases or small print. Find, organize, read and share the research materials you care about, anytime, anywhere. Download today: http://papersapp.co... περισσότερα »

Intensity-Modulated Radiotherapy Gains Ground for Treatment of Stage III Non–Small Cell Lung Cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

Intensity-modulated radiation therapy appears to be preferable to three-dimensional (3D) conformal radiation therapy as part of treatment for patients with locally advanced (stage III) non–small cell lung cancer (NSCLC). Compared with 3D conformal radioth from Cancer via ola Kala on Inoreader http://ift.tt/1MUo8PL via IFTTT

Expert Point of View: Brian D. Kavanagh, MD, MPH, FASTRO

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

At a press conference held during the ASTRO Annual Meeting, ASTRO President-Elect Brian D. Kavanagh, MD, MPH, FASTRO, interim Chair of Radiation Oncology at the University of Colorado, Anschutz Medical Campus, Denver, said, "This study provi from Cancer via ola Kala on Inoreader http://ift.tt/1HFekBK via IFTTT

Is Health Care in the United States a Basic Human Right or an Entitlement?

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

Mercy Killers is a one-man show that details the consequences of a medical health-care catastrophe (breast cancer) in a family.1 This disturbing fictional account is actually a daily event in cancer centers: losing insurance for technica from Cancer via ola Kala on Inoreader http://ift.tt/1MUo5Ub via IFTTT

Debate Over Physician-Assisted Suicide Continues, State by State

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

In 1997, after surviving a storm of high-court legal challenges, Oregon's Death With Dignity Act went into effect, making Oregon the first American state to legalize physician-assisted suicide. The Supreme Court ruled that there was no right to assisted s from Cancer via ola Kala on Inoreader http://ift.tt/1MUo8zm via IFTTT

Dexamethasone to Preempt Radiation-Induced Pain

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

Bone is a common site of metastasis for prostate, breast, and lung cancers, and palliative radiotherapy is often used to treat these metastases. Although it is an effective therapy, severe pain flare following radiation occurs in about one-third of patien from Cancer via ola Kala on Inoreader http://ift.tt/1MUo8iH via IFTTT

Expert Point of View: Brian D. Kavanagh, MD, MPH, FASTRO, and Zain A. Husain, MD

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

You don't need high-tech interventions to prove value. Sometimes we can use a medication that has been around a long time," declared press conference moderator Brian D. Kavanagh, MD, MPH, FASTRO, of the University of Colorado, Anschutz Medical Camp from Cancer via ola Kala on Inoreader http://ift.tt/1HFeh92 via IFTTT

Cooperative Group Study Finds Radiation May Benefit Patients With Atypical Meningiomas

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

Management of the vast majority of meningiomas is straightforward, but treatment of atypical meningiomas has been controversial. Should radiation be part of therapy or not has been the question. The first analysis of Radiation Therapy Oncology Group (RTOG from Cancer via ola Kala on Inoreader http://ift.tt/1MUo5ng via IFTTT

Expert Point of View: Anita Mahajan, MD

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

Anita Mahajan, MD, a radiation oncologist at the University of Texas MD Anderson Cancer Center, Houston, moderated the press conference where these findings were discussed. "Use of radiation for atypic from Cancer via ola Kala on Inoreader http://ift.tt/1MUo82g via IFTTT

FDA Approves Trabectedin for Advanced Liposarcoma and Leiomyosarcoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

The U.S. Food and Drug Administration has approved the novel chemotherapy drug trabectedin ­(Yondelis) for the treatment of specific soft-tissue sarcomas—liposarcoma and leiomyosarcoma—that are unresectable or metastatic. Trabectedin is a novel marine ant from Cancer via ola Kala on Inoreader http://ift.tt/1MUo7LS via IFTTT

FDA Approves Liposomal Irinotecan for Advanced Pancreatic Cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

The U.S. Food and Drug Administration has approved irinotecan liposome injection (Onivyde), in combination with fluorouracil (5-FU) and leucovorin, to treat patients with metastatic pancreatic cancer who have been previously treated with gemcitabine-based chemotherapy. The effectiveness o from Cancer via ola Kala on Inoreader http://ift.tt/1HFegSo via IFTTT

Meta-Analysis Evaluates Benefit of Docetaxel and Bisphosphonates in Hormone-Sensitive Prostate Cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

The results of a meta-analysis conducted in the United Kingdom may guide clinicians in the use of docetaxel and bisphosphonates in patients with hormone-sensitive prostate cancer.1 Claire L. Vale, PhD, Senior Research Scientist at the Medical Research Council Clin from Cancer via ola Kala on Inoreader http://ift.tt/1HFeitB via IFTTT

Expert Point of View: Ronald de Wit, MD, PhD

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

Ronald de Wit, MD, PhD, of Erasmus Medical Center, Rotterdam, Netherlands, called the use of docetaxel in addition to androgen-deprivation therapy "the latest paradigm shift" in the treatment of prostate cancer. The data showing a 10% absolute improvement in survival in the metastatic sett from Cancer via ola Kala on Inoreader http://ift.tt/1HFegSi via IFTTT

Update on Clinical Trials in Metastatic Prostate Cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

Despite the proliferation of new drugs to treat prostate cancer, further progress is proving somewhat elusive, according to three trials presented at the 2015 European Cancer Congress. One study had positive results with orteronel maintenance therapy in patients with metastatic castration from Cancer via ola Kala on Inoreader http://ift.tt/1HFeid3 via IFTTT

Expert Point of View: Bertrand Tombal, MD, PhD

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

We have made major progress by moving docetaxel forward, and now the largest pool of patients who become hormone resistant have received local therapy and then progressed. We have a lot of drugs for castration-resistant prostate cancer, and we are studying them earlier in the course of disease, b from Cancer via ola Kala on Inoreader http://ift.tt/1MUo4PW via IFTTT

Survival Benefit in Metastatic Melanoma Grows Larger in COMBI-v Update

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 15 ώρες

Combined BRAF and MEK inhibition was superior to BRAF inhibition alone in unresectable metastatic melanoma, according to the updated survival analysis of the large randomized COMBI-v trial.1 These findings were reported at the 2015 European Cancer Congress recently held in Vienna, Aust from Cancer via ola Kala on Inoreader http://ift.tt/1HFeicS via IFTTT

Antibody induced by one-dose varicella vaccine soon became weak in children: evidence from a cross-sectional seroepidemiological survey in Beijing, PRC

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 16 ώρες

Background: Numerous post-licensure studies, mostly from field epidemiological evidences such as outbreak surveys, have demonstrated the effectivenesss and insufficiency of one-dose varicella vaccine in outbreak control. Serological evidence of immunization failure is, however, relatively less reported in contrast. A cross-sectional seroepidemiological survey of Beijing residents was performed in 2012 in the People's Republic of China, after the one-dose varicella vaccine had been widely used for several years. Methods: Multistage stratified random sampling method was designed to ... περισσότερα »

The Cerebrovascular Response to Ketamine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 ώρες

The Cerebrovascular Response to Ketamine: A Systematic Review of the Animal and Human Literature.: Background: The aim of the study was to perform a systematic review of the literature on the cerebrovascular/cerebral blood flow (CBF) effects of ketamine in both animal and human subjects. Materials and Methods: We searched MEDLINE, BIOSIS, EMBASE, Global Health, SCOPUS, and Cochrane Library from inception to December 2014. Two reviewers independently identified all manuscripts pertaining to the administration of ketamine in both human and animal subjects in which the impact on CBF/cer... περισσότερα »

Association between childhood exposure to single general anesthesia and neurodevelopment: a systematic review and meta-analysis of cohort study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 ώρες

Association between childhood exposure to single general anesthesia and neurodevelopment: a systematic review and meta-analysis of cohort study: Abstract ObjectiveMany studies have been done to seek the relationship between general anesthesia and neurodevelopment in pediatrics. However, there is no unified conclusion, especially single anesthesia affecting a child before 3 and 4 years. The association between anesthesia and neurodevelopment is studied using a meta-analysis. MethodsWe summarized the currently available evidence by searching PubMed, EMBASE, and the Cochrane libra... περισσότερα »

Aspirin and spinal haematoma after neuraxial anaesthesia: Myth or reality?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 ώρες

Aspirin and spinal haematoma after neuraxial anaesthesia: Myth or reality?: The safety of aspirin therapy in neuraxial anaesthesia has been historically questioned, and the current recommendations are still heterogeneous. A comprehensive review of clinical evidence and a comparative analysis of European and American guidelines were performed. Low-dose aspirin produces a selective, complete and irreversible cyclooxygenase-1 blockade, and higher doses do not increase the antiplatelet effect. Additional cyclooxygenase-2 blockade by high-dose aspirin might decrease the antithrombotic e...περισσότερα »

Epidermal growth factor receptor - inhibition (EGFR-I) in the treatment of neuropathic pain

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 ώρες

Epidermal growth factor receptor - inhibition (EGFR-I) in the treatment of neuropathic pain: Background Neurobiological work has demonstrated that expression of mitogen-activated protein kinases (MAPK) is upregulated on neurones and glial cells after nerve damage. Furthermore, the epidermal growth factor receptor (EGFR) has been identified as having a key role in this process and subsequent interruption of this using EGFR-Inhibitors (EGFR-I), may improve neuropathic pain. The aim of this report was to explore if EGFR-I attenuated neuropathic pain in humans. Methods A selection of ... περισσότερα »

Tracheal tube biofilm removal through a novel closed-suctioning system

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 ώρες

Tracheal tube biofilm removal through a novel closed-suctioning system: an experimental study: Background Tracheal tube biofilm develops during mechanical ventilation. We compared a novel closed-suctioning system vs standard closed-suctioning system in the prevention of tracheal tube biofilm. Methods Eighteen pigs, on mechanical ventilation for 76 h, with *P. aeruginosa* pneumonia were randomized to be tracheally suctioned via the KIMVENT* closed-suctioning system (control group) or a novel closed-suctioning system (treatment group), designed to remove tracheal tube biofilm through...περισσότερα »

Expert Point of View: Christian Blank, MD

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 16 ώρες

Christian Blank, MD, Group Leader of Immunology at the Netherlands Cancer Institute, Amsterdam, formally discussed the COMBI-v findings. He first credited targeted therapy and immunotherapy for almost tripling the chance of patients with metastatic melanoma living beyond 1 year; however, h from Cancer via ola Kala on Inoreader http://ift.tt/1HFegli via IFTTT

PD-1/PD-L1 Inhibitors Show Promise in Additional Tumor Types

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 16 ώρες

While inhibitors of programmed cell death protein 1 (PD-1) or its ligand (PD-L1) are becoming established in melanoma, non–small cell lung cancer, and renal cell carcinoma, their efficacy is also being evaluated in numerous other tumor types, with promising results, according to studies presented from Cancer via ola Kala on Inoreader http://ift.tt/1HFeglf via IFTTT

FDA Approves Ipilimumab  in Adjuvant Treatment of Stage III Melanoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 16 ώρες

On October 28, 2015, the U.S. Food and Drug Administration (FDA) approved the monoclonal antibody ipilimumab (Yervoy) for the adjuvant treatment of patients with cutaneous melanoma with pathologic involvement of regional lymph nodes of more than 1 mm who have undergone complete resection, includi from Cancer via ola Kala on Inoreader http://ift.tt/1HFef0M via IFTTT

Primary vs Metastatic Breast Cancer: The Genetic Landscape Varies

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 16 ώρες

Breast tumors that recur appear to have a different genetic profile than those that do not, and they often demonstrate targetable mutations, according to the largest study of genetic sequencing of breast cancer tissue to date.1 This finding was presented at the 2015 European Cancer Con from Cancer via ola Kala on Inoreader http://ift.tt/1HFef0F via IFTTT

Expert Point of View: Fabrice André, MD, PhD, and Peter Naredi, MD, PhD

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 16 ώρες

In discussing the findings of this study on genetic sequencing of breast cancer tissue, Fabrice André, MD, PhD, of the Gustave Roussy Institute, in Villejuif, France, questioned whether all the genes that were found to be enriched in the rel from Cancer via ola Kala on Inoreader http://ift.tt/1MUo3M6 via IFTTT

Effects of a Mindfulness Meditation Course on Learning and Cognitive Performance among University Students in Taiwan

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Mindfulness training has recently gained much research interest because of its putative benefits for both mental and physical health. However, little is available in its effects on Asian students. Therefore, a quasi-experimental pre/posttest design was used to assess the effects of a one-semester mindfulness meditation course in 152 first-year Taiwanese university students and compared with 130 controls. The Chinese version of the College Learning Effectiveness Inventory (CLEI) and a computer software program focused on specific cognitive tasks were used for the evaluation. Result...περισσότερα »

Water, Vol. 7, Pages 6285-6300: Designing Rainwater Harvesting Systems Cost-Effectively in a Urban Water-Energy Saving Scheme by Using a GIS-Simulation Based Design System

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Current centralized urban water supply depends largely on energy consumption, creating critical water-energy challenge especially for many rapid growing Asian cities. In this context, harvesting rooftop rainwater for non-potable use has enormous potential to ease the worsening water-energy issue. For this, we propose a geographic information system (GIS)-simulation-based design system (GSBDS) to explore how rainwater harvesting systems (RWHSs) can be systematically and cost-effectively designed as an innovative water-energy conservation scheme on a city scale. This GSBDS integrate...περισσότερα »

Nanomaterials, Vol. 5, Pages 1938-1954: Cytotoxicity, Uptake Behaviors, and Oral Absorption of Food Grade Calcium Carbonate Nanomaterials

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Calcium is the most abundant mineral in human body and essential for the formation and maintenance of bones and teeth as well as diverse cellular functions. Calcium carbonate (CaCO3) is widely used as a dietary supplement; however, oral absorption efficiency of CaCO3 is extremely low, which may be overcome by applying nano-sized materials. In this study, we evaluated the efficacy of food grade nano CaCO3 in comparison with that of bulk- or reagent grade nano CaCO3 in terms of cytotoxicity, cellular uptake, intestinal transport, and oral absorption. Cytotoxicity results demonstrate... περισσότερα »

Philosophies, Vol. 1, Pages 28-39: Machine Code and Metaphysics: A Perspective on Software Engineering

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

A major, but too-little-considered problem for Software Engineering (SE) is a lack of consensus concerning Computer Science (CS) and how this relates to developing unpredictable computing technology. We consider some implications for SE of computer systems differing scientific basis, exemplified with the International Standard Organisations Open Systems Interconnection (ISO-OSI) layered architectural model. An architectural view allows comparison of computing technology components facilitating a view of computing as a continuum. For example, at one layer of computer architecture, ...περισσότερα »

Following “the Roots” of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

The use of substances to enhance human abilities is a constant and cross-cultural feature in the evolution of humanity. Although much has changed over time, the availability on the Internet, often supported by misleading marketing strategies, has made their use even more likely and risky. This paper will explore the case of Mitragyna speciosa Korth. (kratom), a tropical tree used traditionally to combat fatigue and improve work productivity among farm populations in Southeast Asia, which has recently become popular as novel psychoactive substance in Western countries. Specifically... περισσότερα »

Preparation of diethylene glycol monomethyl ether monolaurate catalyzed by active carbon supported KF/CaO

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Diethylene glycol monomethyl ether monolaurate (DGMEML) was synthesized via the reaction of diethylene glycol monomethyl ether (DGME) with methyl laurate (ML) by a new solid base catalyst of KF/CaO/AC, which was prepared by impregnation method using active carbon as carrier. The catalysts were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), nitrogen physisorption-desorption and Hammett indicator methods; the effect of the mole ratio of KF to CaO, DGME to ML molar ratio, amount of catalyst, reaction time... περισσότερα »

Prevalence, risk factors, and prognosis of peritoneal metastasis from breast cancer

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Peritoneal metastasis from breast cancer is a serious and deadly condition only limited considered in the literature. Our aim was to study prevalence, risk factors, and prognosis of breast cancer peritoneal metastasis. We retrospectively analyzed 3096 women with a diagnosis of invasive breast cancer. We took into consideration presence and localization of breast cancer distant metastasis as well as the possible risk factors and survival from the diagnosis of the breast cancer metastasis. The prevalence of breast cancer peritoneal metastases was 0.7 % (22/3096), representing the 7.... περισσότερα »

Development of a multiplex real-time PCR assay for detection of Mycoplasma pneumoniae, Chlamydia pneumoniae and mutations associated with macrolide resistance in Mycoplasma pneumoniae from respiratory clinical specimens

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

The aim of this study was to improve detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in clinical specimens by developing a multiplex real-time PCR assay that includes identification of macrolide-resistant M. pneumoniae. Novel assays targeting a M. pneumoniae conserved hypothetical protein gene, M. pneumoniae 23S rRNA gene mutations associated with macrolide resistance and human β-globin gene (an endogenous internal control) were designed and combined with a previously published C. pneumoniae PCR targeting ompA gene. The resulting quadraplex PCR was validated with a pan... περισσότερα »

On intra-supply chain system with an improved distribution plan, multiple sales locations and quality assurance

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Transnational companies, operating in extremely competitive global markets, always seek to lower different operating costs, such as inventory holding costs in their intra- supply chain system. This paper incorporates a cost reducing product distribution policy into an intra-supply chain system with multiple sales locations and quality assurance studied by [Chiu et al., Expert Syst Appl, 40:2669–2676, ( 2013 )]. Under the proposed cost reducing distribution policy, an added initial delivery of end items is distributed to multiple sales locations to meet their demand during the produ... περισσότερα »

Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Acquired or de novo resistance to the selective estrogen receptor modulators tamoxifen and fulvestrant (ICI) is a major barrier to successful treatment of breast cancer. Gene expression patterns in tamoxifen resistant (TamR-MCF-7) cells were compared to their parental cells (MCF-7L) to identify an aberrantly regulated metabolic pathway. TamR-MCF-7 cells are cross resistant to ICI and doxorubicin, and have increased mitochondrial DNA. A small subset of genes had altered expression in TamR-MCF-7 relative to MCF-7L cells. One of the genes, pyruvate dehydrogenase kinase-4 (PDK4), phos...περισσότερα »

Mastectomy rates remain high in Singapore and are not associated with poorer survival after adjusting for age

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Recent reports have suggested that women undergoing mastectomy, instead of wide local excision (WLE) for Stage I and II breast cancers have poorer overall survival. This is particularly important in our setting where mastectomy rates are high. In this study, we evaluated the trends in mastectomy and WLE over a 10-year period at a single institute, identified factors more common among women who underwent mastectomy and specifically examined the effect of surgery on outcome. Retrospective review was performed of 2244 women who underwent curative surgery for non-metastatic breast can...περισσότερα »

Safety, Vol. 1, Pages 28-43: Getting a Hold of Skitching

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Skitching is the act of hitching a ride on a vehicle while riding/using a non-motorized wheeled device (e.g., skateboard or bicycle). To date there has been little discussion of skitching beyond media reports on the serious and often fatal ramification of this activity. To rectify this and improve our understanding of skitching including: who participates; circumstances and motivation; and possible injury prevention strategies, informed by the Haddon's Matrix, an integrative review was undertaken. To gain a comprehensive overview, the review encapsulated information from a variety ...περισσότερα »

Processes, Vol. 3, Pages 749-768: Optimal Design for Reactivity Ratio Estimation: A Comparison of Techniques for AMPS/Acrylamide and AMPS/Acrylic Acid Copolymerizations

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Water-soluble polymers of acrylamide (AAm) and acrylic acid (AAc) have significant potential in enhanced oil recovery, as well as in other specialty applications. To improve the shear strength of the polymer, a third comonomer, 2-acrylamido-2-methylpropane sulfonic acid (AMPS), can be added to the pre-polymerization mixture. Copolymerization kinetics of AAm/AAc are well studied, but little is known about the other comonomer pairs (AMPS/AAm and AMPS/AAc). Hence, reactivity ratios for AMPS/AAm and AMPS/AAc copolymerization must be established first. A key aspect in the estimation of... περισσότερα »

Sports, Vol. 3, Pages 335-345: Using Rowers’ Perceptions of On-Water Stroke Success to Evaluate Sculling Catch Efficiency Variables via a Boat Instrumentation System

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Aim: An effective catch in sculling is a critical determinant of boat velocity. This study used rowers' performance-based judgments to compare three measures of catch slip efficiency. Two questions were addressed: (1) would rower-judged Yes strokes be faster than No strokes? and (2) which method of quantifying catch slip best reflected these judgements? Methods: Eight single scullers performed two 10-min blocks of sub maximal on-water rowing at 20 strokes per minute. Every 30 s, rowers reported either Yes or No about the quality of their stroke at the catch. Results: It was found ... περισσότερα »

Agriculture, Vol. 5, Pages 1116-1134: Carbon Assimilation, Biomass Partitioning and Productivity in Grasses

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Plant growth correlates with net carbon gain on a whole plant basis. Over the last several decades, the driving factors shaping plant morphology and performance have become increasingly clear. This review seeks to explore the importance of these factors for grass performance. Briefly, these fall into factors influencing photosynthetic rates directly, competition between plants in a canopy, and nutrient status and availability. from #Medicine via ola Kala on Inoreader http://ift.tt/1MUgRzr via IFTTT

Relation between the level of lymph node metastasis and survival in locally advanced head and neck squamous cell carcinoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 17 ώρες

BACKGROUND The current head and neck squamous cell carcinoma (HNSCC) staging system may not capture the full prognostic implications of regional lymph node involvement. This study investigated the impact of the level of lymph node metastasis (LNM) on survival. METHODS The Surveillance, Epidemiology, and End Results registry was queried for oral cavity (OC), oropharynx (OP), larynx (LAR), and hypopharynx (HP) HNSCC. A multivariate Cox proportional hazards model was used to evaluate whether the level of LNM was an independent prognostic factor. Site-specific recursive-partitioning...περισσότερα »

Bilateral Malrotation and a Congenital Pelvic Kidney with Varied Vasculature and Altered Hilar Anatomy

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 17 ώρες

Variations of structure and position of the kidney along with variations of renal vessels are most frequently reported. Rotational variations form a rare entity that are not cited in most embryology textbooks. During an educational cadaveric dissection of a 42-year-old male, a complex picture of bilateral anatomical variants was encountered. Malrotation of both kidneys and a left lobulated ectopic kidney along with open hilum was observed. The left kidney showed a pelvic position in front of sacral promontory with three renal arteries retaining its embryological aortoiliac branche... περισσότερα »

Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 17 ώρες

Publication date: Available online 9 November 2015 *Source:*Trends in Cell Biology Author(s): Diletta Di Mitri, Andrea Alimonti Cellular senescence is a permanent growth arrest that is broadly recognized to act as a barrier against tumorigenesis. Senescence is predominant in premalignant tumors, and senescence escape is thought to be required for tumor progression. Importantly, evidences indicate that cell-autonomous mechanisms, such as genetic alterations or therapeutic interventions targeting specific genetic pathways, can affect the senescence response in cancer. Nevertheless, ne... περισσότερα »

Taking Aim at Moving Targets in Computational Cell Migration

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 17 ώρες

[image: alertIcon.gif] Publication date: Available online 10 November 2015 *Source:*Trends in Cell Biology Author(s): Paola Masuzzo, Marleen Van Troys, Christophe Ampe, Lennart Martens Cell migration is central to the development and maintenance of multicellular organisms. Fundamental understanding of cell migration can, for example, direct novel therapeutic strategies to control invasive tumor cells. However, the study of cell migration yields an overabundance of experimental data that require demanding processing and analysis for results extraction. Computational methods and tools... περισσότερα »

CNS Masson Tumors: Frequent Association With Therapeutic Radiation.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

CNS Masson Tumors: Frequent Association With Therapeutic Radiation.: Masson tumor (MT, papillary endothelial hyperplasia) is an exaggerated form of thrombus reorganization rarely occurring in the central nervous system (CNS), where it presents as a mass or hemorrhage in parenchyma, meninges, or venous sinuses. MT is subclassified as type 1 arising within a histologically normal vessel, type 2 associated with a ruptured vascular malformation, and extravascular. Limited reports of CNS MT after radiosurgery, or especially external radiation therapy, have emerged. We searched our databa...περισσότερα »

Mammary Analogue Secretory Carcinoma of Salivary Glands: Molecular Analysis of 25 ETV6 Gene Rearranged Tumors With Lack of Detection of Classical ETV6-NTRK3 Fusion Transcript by Standard RT-PCR: Report of 4 Cases Harboring ETV6-X Gene Fusion.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Mammary Analogue Secretory Carcinoma of Salivary Glands: Molecular Analysis of 25 ETV6 Gene Rearranged Tumors With Lack of Detection of Classical ETV6-NTRK3 Fusion Transcript by Standard RT-PCR: Report of 4 Cases Harboring ETV6-X Gene Fusion.: ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MASC), and has not been documented in any other ... περισσότερα »

Duration criterion of Respiratory Events for Children with Obstructive Sleep Apnea

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Duration criterion of Respiratory Events for Children with Obstructive Sleep Apnea: To investigate the duration criterion of respiratory events in children with obstructive sleep apnea syndrome (OSAS) by analyzing standard nocturnal polysomnograms (PSG). To provide reference values for pediatric PSG.

Metabolic Alterations in Adolescents with Obstructive Sleep Apnea

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Metabolic Alterations in Adolescents with Obstructive Sleep Apnea: Obesity is one of the leading health concerns in developed and in developing countries. The risk of obstructive sleep apnea (OSA) is greatly increased by obesity. Obesity is known to be associated with the Metabolic Syndrome and cardiovascular disease in adults. This same association in children is not well defined. Understanding the relationship of obesity, OSA, and metabolic alterations in children would improve understanding of the risks of cardiovascular disease into adulthood.

Fetal distress and circulatory disturbance in monochorionic twins: possible risk factors for sialadenitis?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Fetal distress and circulatory disturbance in monochorionic twins: possible risk factors for sialadenitis?: Neonatal sialadenitis is a rare condition. The vast majority of cases are caused by Staphylococcus aureus with predominant involvement of the parotid gland and need for long-term antimicrobial therapy. We reviewed three distinct cases of submandibular sialadenitis in preterm infants from monochorionic pregnancies. The association with neonatal sialadenitis is unproven. We speculate about the role of fetal distress and circulatory compromise in monochorionic twins as a risk fac...περισσότερα »

Polymorphic variants near 1p22 and 20q11.2 loci and the risk of non-syndromic cleft lip and palate in South Indian Population

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Polymorphic variants near 1p22 and 20q11.2 loci and the risk of non-syndromic cleft lip and palate in South Indian Population: Recent genome-wide association studies (GWAS) have reported multiple genetic risk loci for non-syndromic orofacial clefts (NSOFCs) in many populations. However, the contribution of these loci to NSOFC in India, which comprises one-fifth of the global population, is completely lacking. Our aim was to replicate the association of the SNPs located on 1p22 chromosomal loci (rs540026, rs481931) and 20q11.2 (rs13041247, rs11696257) in the aetiology of NSOFCs, in S...περισσότερα »

The “multiport airway adapter” in flexible bronchoscopy for peripheral bronchial foreign bodies in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

The “multiport airway adapter” in flexible bronchoscopy for peripheral bronchial foreign bodies in children: Many children require emergency foreign body removal by bronchoscopy. Although a flexible bronchoscope is frequently used for removal of a bronchial foreign body in children, this procedure is difficult in children with a narrow tracheal lumen, even using a thin flexible bronchoscope. This report describes the use of a multiport airway adaptor to remove a bronchial foreign body with a flexible bronchoscope. The thicker forceps etc. were passed alongside the flexible bronchosc... περισσότερα »

Auditory neuropathy spectrum disorder in hypomyelinating leukodystrophy - A case study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Auditory neuropathy spectrum disorder in hypomyelinating leukodystrophy - A case study: Leukodystrophy is one of a group of disorders characterized by degeneration of white matter in the brain. The basic defect in this disorder is directly related to the synthesis and maintenance of myelin membranes. When damage occurs to white matter, immune responses may lead to inflammation in the central nervous system along with loss of myelin. Characteristics of leukodystrophy include decreased motor function, spasticity, muscle rigidity, and eventual degeneration of the senses of vision and h...περισσότερα »

Combined endonasal and neurosurgical resection of a congenital teratoma with pharyngeal, intracranial and orbital extension: case report, surgical technique and review of the literature

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Combined endonasal and neurosurgical resection of a congenital teratoma with pharyngeal, intracranial and orbital extension: case report, surgical technique and review of the literature: This study reports a patient with a large teratoma involving the oropharynx, the nasopharynx and the left orbit, with intracranial extension. This case represents one of the first reported instances of such an association. A literature review reporting head and neck teratomas with intracranial involvement is also presented.

Auditory perception of non-sense and familiar Bengali rhyming words in children with without SLD

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Auditory perception of non-sense and familiar Bengali rhyming words in children with without SLD: Background Rhyming ability is among the earliest metaphonological skills to be acquired during the process of speech and language acquisition. Metalinguistic skills, particularly metaphonological skills greatly influence language learning during early, school grades and reportedly children with learning disorders are poor at these skills.Aim and objectives To develop and validate a Bengali rhyming checklist and study the auditory perception of non-sense and familiar Bengali rhyming word... περισσότερα »

Radiation dose reduction in postoperative computed position control of cochlear implant electrodes in lambs–an experimental study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Radiation dose reduction in postoperative computed position control of cochlear implant electrodes in lambs–an experimental study: Cochlear implants (CI) are standard treatment for prelingually deafened children and postlingually deafened adults. Computed tomography (CT) is the standard method for postoperative imaging of the electrode position. CT scans accurately reflect electrode depth and position, which is essential prior to use. However, routine CT examinations expose patients to radiation, which is especially problematic in children. We examined whether new CT protocols could...περισσότερα »

A novel predictive marker for the viscosity of otitis media with effusion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

A novel predictive marker for the viscosity of otitis media with effusion: Otitis media with effusion (OME) is one of the most common childhood conditions, affecting approximately 90% of children before school age [1]. OME is characterized by an accumulation of fluid in the middle ear, behind an intact tympanic membrane, in the absence of signs or symptoms of acute infection [2].

Extracellular matrix for repair of type IV laryngotracheo-esophageal cleft

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Extracellular matrix for repair of type IV laryngotracheo-esophageal cleft: Type IV laryngotracheo-esophageal cleft (LTEC) extending to the level of the carina presents unique challenges to operative repair, particularly with respect to soft tissue durability. This is the first report of CorMatrix® extra-cellular matrix (ECM) material use as an interposition graft in a four-layered LTEC repair. At day seven post-operatively, there was epithelialization along the surface of the trachea. At three months, she was stable for tracheotomy. At six months, the posterior wall resembled compl... περισσότερα »

Anti CD163+, Iba1+, and CD68+ Cells in the Adult Human Inner Ear: Normal Distribution of an Unappreciated Class of Macrophages/Microglia and Implications for Inflammatory Otopathology in Humans.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Anti CD163+, Iba1+, and CD68+ Cells in the Adult Human Inner Ear: Normal Distribution of an Unappreciated Class of Macrophages/Microglia and Implications for Inflammatory Otopathology in Humans.: Hypothesis: Identification, characterization, and location of cells involved in the innate immune defense system of the human inner ear may lead to a better understanding of many otologic diseases and new treatments for hearing and balance-related disorders. Background: Many otologic disorders are thought to have, as part of their disease process, an immune component. Although resident macro... περισσότερα »

Electro-Mechanical Stimulation of the Cochlea by Vibrating Cochlear Implant Electrodes.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Electro-Mechanical Stimulation of the Cochlea by Vibrating Cochlear Implant Electrodes.: Introduction: Electro-acoustic stimulation (EAS) of the cochlea uses the preserved residual low-frequency hearing for acoustic stimulation in combination with electrical stimulation. The acoustic low-frequency component is amplified and high-frequency hearing is enhanced by a cochlear implant (CI). In this work, the feasibility of EAS by the floating mass transducers (FMTs) firmly attached to the implanted electrode was investigated and the achieved stapes displacement was compared with sound st... περισσότερα »

The Efficacy of Color-Mapped Diffusion-Weighted Images Combined With CT in the Diagnosis and Treatment of Cholesteatoma Using Transcanal Endoscopic Ear Surgery.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

The Efficacy of Color-Mapped Diffusion-Weighted Images Combined With CT in the Diagnosis and Treatment of Cholesteatoma Using Transcanal Endoscopic Ear Surgery.: Objective: To assess the efficacy of a color-mapped diffusion-weighted image combined with a computed tomography scan (CMDWI-CT) in preoperatively evaluating the anatomical location of cholesteatomas and determining whether a patient is indicated for transcanal endoscopic ear surgery (TEES) to reduce intraoperative switching to microscopic ear surgery (MES). Study Design: Prospective case study. Setting: A single university ... περισσότερα »

Health Utility Improves After Surgery for Superior Canal Dehiscence Syndrome.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Health Utility Improves After Surgery for Superior Canal Dehiscence Syndrome.: Objective: Health utility value (HUV) is an outcome measure used to calculate quality adjusted life years (QALYs) and to determine cost-effectiveness of medical treatments. Herein, we measure HUV in patients with superior canal dehiscence syndrome (SCDS) before and after surgical repair. Health utility values of patients with SCDS are compared to normative data of the general United States population. Study Design: Retrospective review of prospectively collected data. Patients: Adult patients with SCDS. Set... περισσότερα »

Evaluation of Magnetic Resonance Imaging Diagnostic Approaches for Vestibular Schwannoma Based on Hearing Threshold Differences Between Ears: Added Value of Auditory Brainstem Responses.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Evaluation of Magnetic Resonance Imaging Diagnostic Approaches for Vestibular Schwannoma Based on Hearing Threshold Differences Between Ears: Added Value of Auditory Brainstem Responses.: Objective: This study investigates the most appropriate audiometric criterion in deciding which patients with asymmetric hearing loss should be referred to MRI to exclude a lesion in the cerebellopontine angle (CPA). Careful selection of patients could improve resource utilization while preventing unnecessary investigations with accompanying burden and costs. Study Design: Retrospective case review....περισσότερα »

Dexamethasone Protects Against Radiation-induced Loss of Auditory Hair Cells In Vitro.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Dexamethasone Protects Against Radiation-induced Loss of Auditory Hair Cells In Vitro.: Hypothesis: Dexamethasone (DXM) protects against radiation-induced loss of auditory hair cells (HCs) in rat organ of Corti (OC) explants by reducing levels of oxidative stress and apoptosis. Background: Radiation-induced sensorineural hearing loss (HL) is progressive, dose-dependent, and irreversible. Currently, there are no preventative therapeutic modalities for radiation-induced HL. DXM is a synthetic steroid that can potentially target many of the pathways involved in radiation-induced ototoxi... περισσότερα »

Efficacy and Safety of Transcanal Endoscopic Ear Surgery for Congenital Cholesteatomas: A Preliminary Report.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Efficacy and Safety of Transcanal Endoscopic Ear Surgery for Congenital Cholesteatomas: A Preliminary Report.: Objective: Transcanal endoscopic ear surgery (TEES) can provide greater visual access during resection of middle ear disease than the operating microscope. The purpose of this study was to determine the safety and efficacy of TEES when used for the management of congenital cholesteatoma (CC) in children. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Twelve children with CC confined to the middle ear underwent TEES. Seven children were P...περισσότερα »

Otopathology of Vasculitis in Granulomatosis With Polyangitis.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Otopathology of Vasculitis in Granulomatosis With Polyangitis.: Objective: To describe the temporal bone histopathology of vasculitis in granulomatosis with polyangitis. Background: Granulomatosis with polyangitis is an autoimmune disease that presents as granulomatosis and vasculitis. Otologic findings, including otitis media, hearing loss, vertigo, and facial paralysis are common in this condition. Material and Methods: The temporal bones of four subjects with manifestations of vasculitis attributed to granulomatosis with polyangitis were studied under light microscopy. Results: Th... περισσότερα »

Histopathology of the Human Inner Ear in a Patient With Sensorineural Hearing Loss Caused by a Variant in DFNA5.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Histopathology of the Human Inner Ear in a Patient With Sensorineural Hearing Loss Caused by a Variant in DFNA5.: Hypothesis: Describe the histopathology of the inner ear in a patient with hearing loss caused by a pathogenic variant of the DFNA5 gene. Background: Variants in DFNA5 have been described as causing an autosomal dominant nonsyndromic sensorineural hearing loss. To date, there has been no description of the histopathology of the inner ear in humans with hearing loss because of pathogenic variants in DFNA5. Methods: Temporal bone histopathology by light microscopy, next-gene... περισσότερα »

Incidence of Retrocochlear Pathology Found on MRI in Patients With Non-Pulsatile Tinnitus.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Incidence of Retrocochlear Pathology Found on MRI in Patients With Non-Pulsatile Tinnitus.: Objective: To identify the incidence of retrocochlear pathology on MRI in patients with non-pulsatile tinnitus. Study Design: Retrospective review. Setting: Tertiary Referral Center. Patients: Adults with MRIs performed between March 1, 2008 and February 1, 2014 for non-pulsatile tinnitus with or without hearing loss. Intervention: MRI. Main Outcome Measure: Incidence of retrocochlear pathology. Results: Of the 218 patients who met inclusion criteria, 198 (91.3%) had unremarkable MRIs. Six patien...περισσότερα »

Outcomes in Stapedotomy Surgery: The Learning Curve Redefined.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Outcomes in Stapedotomy Surgery: The Learning Curve Redefined.: Objective: The aim of this study is to determine if the cumulative summation test for the learning curve (LC-CUSUM) and the cumulative summation graph (CUSUM) can be used to demonstrate landmark points of competence and maintenance of proficiency in stapes surgery over a continuous time period. Study Design: Retrospective review from January 1999 until August 2014. Setting: Tertiary referral hospital. Patients: All adult patients with confirmed otosclerosis. Intervention(s): Two-hundred and four primary and revision stapedo...περισσότερα »

Speech Perception of Elderly Cochlear Implant Users Under Different Noise Conditions.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Speech Perception of Elderly Cochlear Implant Users Under Different Noise Conditions.: Objective: The primary objective of this study was the comparison of younger and older (>75 yr) CI recipients' performance for speech perception in quiet and in competing continuous and fluctuating noise. Study Design: Prospective, comparative clinical study. Setting: University hospital. Patients: Fifty patients, 25 older and 25 younger than 75 years, with a postlingually acquired profound hearing loss who received a cochlear implant at least 1 year before study start were enrolled. Interventions: ... περισσότερα »

The prevalence of primary headache disorders in Nepal: a nationwide population-based study

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 17 ώρες

Background: Headache disorders are among the most prevalent and burdensome global public-health problems. Within countries, health policy depends upon knowledge of health within the local populations, but the South-East Asia Region (SEAR), among WHO's six world regions, is the only one for which no national headache prevalence data are available. Methods: In a cross-sectional population-based study, adults representative of the Nepali-speaking population aged 18–65 years and living in Nepal were randomly recruited using stratified multistage cluster sampling. They were visited una...περισσότερα »

Performance Evaluation of Multimodal Multifeature Authentication System Using KNN Classification

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 17 ώρες

This research proposes a multimodal multifeature biometric system for human recognition using two traits, that is, palmprint and iris. The purpose of this research is to analyse integration of multimodal and multifeature biometric system using feature level fusion to achieve better performance. The main aim of the proposed system is to increase the recognition accuracy using feature level fusion. The features at the feature level fusion are raw biometric data which contains rich information when compared to decision and matching score level fusion. Hence information fused at the f... περισσότερα »

Synthesis, Antiviral Activity and Resistance of a Novel Small Molecule HIV-1 Entry Inhibitor

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Publication date: Available online 10 November 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Francesca Curreli, Kashfia Haque, Lihua Xie, Qian Qiu, Jinfeng Xu, Weizhong Yong, Xiaohe Tong, Asim K. Debnath One of the most critical requirements of the infection of the human immunodeficiency virus type 1 (HIV-1) is the interaction of its surface envelope glycoprotein gp120 with the cellular receptor CD4, which initiates virus entry to cells. Therefore, envelope glycoprotein gp120 has been validated as a potential target to develop HIV-1 entry inhibitors. Here we report the e...περισσότερα »

Corrigendum to “Reengineered tricyclic anti-cancer agents” [Bioorg. Med. Chem. 23 (2015) 6528–6534]

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Publication date: Available online 9 November 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): David B. Kastrinsky, Jaya Sangodkar, Nilesh Zaware, Kimberly McClinch, Caroline C. Farrington, Heather M. Giannini, Sudeh Izadmehr, Neil S. Dhawan, Goutham Narla, Michael Ohlmeyer from #Medicine via ola Kala on Inoreader http://ift.tt/1iR2SMT via IFTTT

Design, Synthesis and Evaluation of Antiestrogen and Histone Deacetylase Inhibitor Molecular Hybrids

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 ώρες

Publication date: Available online 10 November 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Rodrigo Mendoza-Sanchez, David Cotnoir-White, Justyna Kulpa, Isabel Jutras, Joshua Pottel, Nicolas Moitessier, Sylvie Mader, James L. Gleason The combination of antiestrogens and histone deacetylase inhibitors (HDACi) has been found to be antiproliferative in breast cancer models. We designed and synthesized hybrid structures which combined structural features of the pure antiestrogen ICI-164,384 and HDACi's SAHA and entinostat in a single bifunctional molecule. The hybrids retai... περισσότερα »

upper respiratory tract infection; +26 new citations

Alexandros G. SfakianakisστοHead and NeckΠριν από 17 ώρες

26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2015/11/10 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/QGMHBq(((upper%20respiratory%20tract%20infection)%20AND%20%222015%2F11%2F09%2007.28%22%5B...περισσότερα »

Clinical Validation of a Predictive Model for the Presence of Cervical Lymph Node Metastasis in Papillary Thyroid Cancer

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

*Condition*: Papillary Thyroid Cancer *Intervention*: *Sponsor*: University of Colorado, Denver *Recruiting* - verified November 2015 from #Medicine via ola Kala on Inoreader http://ift.tt/1RLgZiL via IFTTT

Endodrill vs. Conventional Biopsy. Diagnostics and Genetic Analysis

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

*Condition*: Esophageal Neoplasm *Interventions*: Device: Endodrill Biopsy; Device: Conventional Biopsy forceps *Sponsor*: Region Skane *Not yet recruiting* - verified November 2015 from #Medicine via ola Kala on Inoreader http://ift.tt/1WP8JzB via IFTTT

Exploring the Neuro-Immune Basis of Cancer-Related Fatigue Using Behavioral Measures

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

*Condition*: Head and Neck Cancer *Interventions*: Behavioral: Computerized Tasks; Behavioral: Questionnaires *Sponsor*: M.D. Anderson Cancer Center *Recruiting* - verified November 2015 from #Medicine via ola Kala on Inoreader http://ift.tt/1liGttI via IFTTT

Neuropathic Pain in Head and Neck Cancer

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

*Condition*: Head and Neck Cancer *Interventions*: Behavioral: Questionnaires; Other: Quantitative Sensory Testing *Sponsors*: M.D. Anderson Cancer Center; National Institute of Dental and Craniofacial Research (NIDCR) *Recruiting* - verified November 2015 from #Medicine via ola Kala on Inoreader http://ift.tt/1RLgZiJ via IFTTT

Safety and Efficacy of IZN-6N4 Oral Rinse for the Prevention of Oral Mucositis in Patients With Head and Neck Cancer

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

*Condition*: Oral Mucositis *Intervention*: Drug: IZN-6N4 *Sponsor*: Izun Pharma Ltd *Recruiting* - verified November 2015 from #Medicine via ola Kala on Inoreader http://ift.tt/1RLh0U5 via IFTTT

Viruses, Vol. 7, Pages 5792-5800: Genomic Mining Reveals Deep Evolutionary Relationships between Bornaviruses and Bats

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Bats globally harbor viruses in order Mononegavirales, such as lyssaviruses and henipaviruses; however, little is known about their relationships with bornaviruses. Previous studies showed that viral fossils of bornaviral origin are embedded in the genomes of several mammalian species such as primates, indicative of an ancient origin of exogenous bornaviruses. In this study, we mined the available 10 bat genomes and recreated a clear evolutionary relationship of endogenous bornaviral elements and bats. Comparative genomics showed that endogenization of bornaviral elements frequent... περισσότερα »

Risks, Vol. 3, Pages 491-514: On the Joint Analysis of the Total Discounted Payments to Policyholders and Shareholders: Dividend Barrier Strategy

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

In the compound Poisson insurance risk model under a dividend barrier strategy, this paper aims to analyze jointly the aggregate discounted claim amounts until ruin and the total discounted dividends until ruin, which represent the insurer's payments to its policyholders and shareholders, respectively. To this end, we introduce a Gerber–Shiu-type function, which further incorporates the higher moments of these two quantities. This not only unifies the individual study of various ruin-related quantities, but also allows for new measures concerning covariances to be calculated. The ... περισσότερα »

Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Polygonum multiflorum is a traditional Chinese medicine with a long history in hair growth promotion and hair blackening. The purpose of the study was to examine the effect and the mechanism of Polygonum multiflorum in hair blackening. C57BL/6 mice hair fade was induced with H2O2 and used in this research. Hair pigmentogenesis promotion activities of Polygonum Multiflorum Radix (PMR, raw crude drug), Polygonum Multiflorum Radix Preparata (PMRP, processed crude drug), and their major chemical constituent TSG were investigated. The regulation effects of several cytokines and enzymes... περισσότερα »

Optimization of Extraction Parameters for Enhanced Production of Ovotransferrin from Egg White for Antimicrobial Applications

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Ovotransferrin is the second most abundant protein (~12-13% of the total egg protein) in egg white after ovalbumin. Ovotransferrin is a potent natural antimicrobial agent as it possesses antibacterial, antifungal, and antiviral properties and is also the major metal binding protein found in egg, which makes it an industrially important protein. Ovotransferrin was extracted from egg white using its metal (iron) binding properties. In the present study, eggs from two different sources were used (fresh local eggs from domestic household source and poultry eggs from shops) to compare t... περισσότερα »

Improved Pre-miRNA Classification by Reducing the Effect of Class Imbalance

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

MicroRNAs (miRNAs) play important roles in the diverse biological processes of animals and plants. Although the prediction methods based on machine learning can identify nonhomologous and species-specific miRNAs, they suffered from severe class imbalance on real and pseudo pre-miRNAs. We propose a pre-miRNA classification method based on cost-sensitive ensemble learning and refer to it as MiRNAClassify. Through a series of iterations, the information of all the positive and negative samples is completely exploited. In each iteration, a new classification instance is trained by the... περισσότερα »

Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE:To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH).METHODS:The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S1P phosphatase expression were measured at day 3, 5, 7, 9.RESULTS: The expression of S1P was enhanced in the cerebral vasospasm after subarachnoid hemorrhage in the rabbits. And S1P expression was consistent with the basilar artery ... περισσότερα »

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE: To investigate the effect of low-level laser therapy on bone healing in diabetic rats.METHODS: Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was performed every 48h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed.RESULTS: Low-level laser therapy significantly increased alkaline... περισσότερα »

Physiological and biochemical measurements before, during and after pregnancy of healthy rats

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE:To analyze the physiological and biochemical measurements before, during and after pregnancy of healthy rats.METHODS:Wistar adult females rats (n=8) were weighed and blood samples were obtained before, during and after pregnancy for biochemical determinations, chow intake, water consumption and milk production were evaluated. At day 10 postpartum, the rats were killed for weighing of organs and adipose tissues.RESULTS: The results showed increase in body weight, serum insulin and ingestion of water and chow. At day 17 pregnancy, presented normal values in the OGTT. At days... περισσότερα »

Low serum free and total tri-iodothyronine hormones as possible prognostic factors in liver cirrhotic patients due to chronic hepatitis C

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Low serum free and total tri-iodothyronine hormones as possible prognostic factors in liver cirrhotic patients due to chronic hepatitis C: *AbdAllah Ahmed El-Sawy, Mohamed Abd El-Raouf Tawfik* Thyroid Research and Practice 2015 12(3):87-92 Background and Aim: Liver and thyroid hormones are powerfully correlated so thyroid hormone abnormalities are seen in patients of liver diseases We evaluated serum thyroid hormone levels in chronic hepatitis C cirrhotic patients with and without hepatic encephalopathy. Patients and Methods: Our study was carried out on one hundred patients wit...περισσότερα »

Acute systemic response to intraperitoneal implantation of polypropylene mesh/chitosan-based film composite in pigs

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE:To assess the systemic response of pigs to the intraperitoneal implantation of polypropylene mesh associated with chitosan-based film with a degree of deacetylation of 95%.METHODS:Blood samples were collected 24 hours before, and two and seven days after surgery. Systemic reactions were evaluated based on white blood cell count, C-reactive protein, and total serum protein, albumin and globulin levels.RESULTS:The systemic response was proportional to the composite response induced by polypropylene mesh, and the tissue inflammatory response was higher in the PP group (p=0.00... περισσότερα »

Analysis of the healing process of the wounds occurring in rats using lasertherapy in association with hydrocolloid

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE: To evaluate wound healing in rats by using low-level laser therapy (LLLT) associated with hydrocolloid occlusive dressing. METHODS: Forty male, adult, Wistar rats were used, distributed into four groups: LG (received 2 J/cm² of laser therapy); HG (treated with hydrocolloid); LHG (treated with 2 J/cm² of laser therapy and hydrocolloid); and the CG (treated with 1 mL of 0.9% saline). The wound was evaluated at pre-determined periods 3rd and 7th days, considering the macroscopic and histological parameters (inflammatory cells, capillary neoformation, fibroblasts, collagen fo... περισσότερα »

Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE:Toevaluate the effects of nitrofurazone on the correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue in rats.METHODS: A defect in the abdominal wall was created and corrected with polypropylene mesh in 20 rats. They were randomly distributed into four groups: control, fibrous mesh, nitrofurazone and nitrofurazone dip in the mesh. Euthanasia was performed in 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects.RESULTS:All animals had adhesions. However, no statistically... περισσότερα »

The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 18 ώρες

Bronchial epithelial cells are the first barrier of defense against respiratory pathogens. Dust particles as extracellular stimuli are associated with inflammatory reactions after inhalation. It has been reported that dust particles induce intracellular Ca2+ signal, which subsequently increases cytokines production such as interleukin- (IL-) 8. However, the study of therapeutic blockades of Ca2+ signaling induced by dust particles in human bronchial epithelial cells is poorly understood. We investigated how to modulate dust particles-induced Ca2+ signaling and proinflammatory cyto... περισσότερα »

Clinical Trial and In Vitro Study for the Role of Cartilage and Synovia in Acute Articular Infection

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 18 ώρες

Objective. Osteoarthritis is a long-term complication of acute articular infections. However, the roles of cartilage and synovia in this process are not yet fully understood. Methods. Patients with acute joint infections were enrolled in a prospective clinical trial and the cytokine composition of effusions compared in patients with arthroplasty (n = 8) or with intact joints (n = 67). Cytokines and cell function were also analyzed using a human in vitro model of joint infection. Results. Synovial IL-1β levels were significantly higher in patients with arthroplasty (p = 0.004). High... περισσότερα »

Perioperative Jehovah's Witnesses

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Perioperative Jehovah's Witnesses: a review: There are many patient groups who may refuse blood products; the most well known amongst them is the Jehovah's Witness faith. Treatment of anaemia and bleeding in such patients presents a challenge to medical, anaesthetic, and surgical teams. This review examines the perioperative issues and management of Jehovah's Witnesses. The history and beliefs of Jehovah's Witnesses are outlined together with their impact on ethics and the law, and different management options throughout the perioperative period are discussed.

Inotropes and vasopressors are frequently administered to critically ill patients in order to improve haemodynamic function and restore adequate organ perfusion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

The Effect of inotropes and vasopressors on mortality: a meta-analysis of randomized clinical trials: Background Inotropes and vasopressors are frequently administered to critically ill patients in order to improve haemodynamic function and restore adequate organ perfusion. However, some studies have suggested a possible association between inotrope administration and increased mortality. We therefore performed a meta-analysis of randomized trials published in the last 20 yr to investigate the effect of these drugs on mortality. Methods BioMedCentral, PubMed, Embase and the Cochran...περισσότερα »

Combination of videolaryngoscope and tracheal tube introducer for difficult infant airway management

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Combination of videolaryngoscope and tracheal tube introducer for difficult infant airway management: Emergency infant airway management is challenging, especially in difficult airway cases. Here, we report a successful case of difficult infant airway management in which a videolaryngoscope was used in combination with a tracheal tube introducer to perform awake intubation.

Optimal length of the pre-inserted tracheal tube for excellent view in nasal fiberoptic intubation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Optimal length of the pre-inserted tracheal tube for excellent view in nasal fiberoptic intubation: Abstract PurposeInexperienced physicians frequently have difficulty performing nasal fiberoptic intubation. A pre-inserted tracheal tube of the appropriate length allows an excellent view of the laryngeal opening. The purpose of this study was to determine the ideal length of a pre-inserted tracheal tube for nasal fiberoptic intubation and to investigate if it could be predicted from easily measureable patient parameters. MethodsThis was an observational study in which data on ad... περισσότερα »

Implementing enhanced recovery after bariatric surgery protocol

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Implementing enhanced recovery after bariatric surgery protocol: a retrospective study: AbstractWhile the demand for bariatric surgery is increasing, hospital capacity remains limited. The ERABS (Enhanced Recovery After Bariatric Surgery) protocol has been implemented in a number of bariatric centers. We retrospectively compared the operating room logistics and postoperative complications between pre-ERABS and ERABS periods in an academic hospital. The primary endpoint was the length of stay in hospital. The secondary endpoints were turnover times—the time required for preparing th...περισσότερα »

Anesthetic Management of a Case of Posterior Fossa Tumor With An Intracardiac Mass.

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Anesthetic Management of a Case of Posterior Fossa Tumor With An Intracardiac Mass

Meta-areas of the Trigeminocardiac Reflex Within the Skull Base

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Meta-areas of the Trigeminocardiac Reflex Within the Skull Base: A Neuroanatomic "Thinking" Model.

Teaching basic fiberoptic intubation skills in a simulator: initial learning and skills decay

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Teaching basic fiberoptic intubation skills in a simulator: initial learning and skills decay: Abstract PurposeGenerally, novices are taught fiberoptic intubation on patients by attending anesthesiologists; however, this approach raises patient safety concerns. Patient safety should improve if novice learners are trained for basic skills on simulators. In this educational study, we assessed the time and number of attempts required to train novices in fiberoptic bronchoscopy and fiberoptic intubation on simulators. Because decay in skills is inevitable, we also assessed fiberoptic ... περισσότερα »

Evaluation of an automated knowledge based treatment planning system for head and neck

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Background: This study evaluated an automated inverse treatment planning algorithm, Pinnacle Auto-Planning (AP), and compared automatically generated plans with historical plans in a large cohort of head and neck cancer patients. Methods: Fifty consecutive patients treated with volumetric modulated arc therapy (Eclipse, Varian Medical System, Palo Alto, CA) for head and neck were re-planned with AP version 9.10. Only one single cycle of plan optimization using one single template was allowed for AP. The dose to the planning target volumes (PTV's; 3–4 dose levels), the organs at ri... περισσότερα »

Orbital Complication Following Calcium Hydroxylapatite Filler Injection.

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Orbital Complication Following Calcium Hydroxylapatite Filler Injection.: Cosmetic facial fillers have gained immense popularity in recent years. Although some patients opt to undergo an injection over surgery in light of the risks of an operation, there have been numerous reports of complications from these injections, including blindness. It is thought that filler particles can migrate within an artery and become emboli within small vessels. This case of focal orbital inflammation and dysmotility as a consequence of calcium hydroxylapatite filler injection in the face has not yet ... περισσότερα »

Effects of fentanyl on serotonin syndrome-like behaviors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Effects of fentanyl on serotonin syndrome-like behaviors in rats: AbstractEmerging evidence from case reports suggests that fentanyl may precipitate potentially life-threatening serotonin syndrome in patients taking serotonergic drugs. However, the underlying mechanism of the association between serotonin syndrome and fentanyl remains under investigation. We therefore investigated the pharmacological effects of an analgesic dose of fentanyl (0.2 mg/kg) injected subcutaneously (s.c.) on serotonergic toxicity-like responses in rats. Rats were s.c. injected with 0.75 mg/kg 8-OH-DPAT, ... περισσότερα »

Transcranial Color Duplex Ultrasound: A Reliable Tool for Cerebral Hemodynamic Assessment in Brain Injuries.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Transcranial Color Duplex Ultrasound: A Reliable Tool for Cerebral Hemodynamic Assessment in Brain Injuries.: Background: Transcranial color duplex ultrasound (TCCD) is becoming an important tool for cerebral monitoring of brain-injured patients. To date, TCCD reproducibility has been studied in healthy volunteers or patients with subarachnoid hemorrhage and its efficiency in many brain injuries has not been proved. Our aim was to evaluate TCCD interobserver agreement in different brain injuries. Patients and Methods: We performed a prospective monocentric trial conducted from Januar... περισσότερα »

Anticoagulant conversion in the elderly: pitfalls

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Anticoagulant conversion in the elderly: pitfalls: The prevalence of medical conditions representing a risk for thromboembolic complications and requiring antithrombotic therapy increases gradually with age. Two cases of fatal noncritical organ bleeding complication that occurred during the conversion period from initial fondaparinux to vitamin K antagonist are presented. An 81-year-old obese female patient (body mass index 43 kg/m2) with previous postoperative thrombosis underwent uneventful total knee replacement under spinal anesthesia. She presented with popliteal hematoma durin...περισσότερα »

Accidental dural puncture during epidural insertion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Accidental dural puncture during epidural insertion: In a retrospective study, Kuroda et al [1] investigated factors related to accidental dural puncture (ADP) in patients under epidural anesthesia and found that ADP was significantly related to puncture site and advanced age in surgical patients undergoing epidural anesthesia. However, they just investigated patient factors and ignored operator experience.

Postoperative complications associated with extubation strategies following palatoplasty: a single-center retrospective analysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Postoperative complications associated with extubation strategies following palatoplasty: a single-center retrospective analysis: Abstract PurposePalatoplasty carries a high risk of airway obstruction as a postoperative complication. Since 2007, the protocol in our hospital has been to leave an endotracheal tube in place after surgery while the patient is moved to the pediatric intensive care unit. Extubation is then performed after achievement of hemostasis and recovery of consciousness. We compared the cases over the 5-year periods before and after the introduction of this revi... περισσότερα »

Phenylephrine hydrochloride modified-release tablets for nasal congestion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

: a randomized, placebo-controlled trial in allergic rhinitis patients via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 7 November 2015 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Eli O. Meltzer, Paul H. Ratner, Thomas McGraw BackgroundOver-the-counter phenylephrine hydrochloride (PEH) is used for relief of nasal congestion caused by allergic rhinitis; however, data to support its efficacy are lacking. The US Food and Drug Administration recommended clinical trials to evaluate the efficacy and safety of PEH in patien... περισσότερα »

Asthma severity, not asthma control, is worse in atopic compared with nonatopic adolescents with asthma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Asthma severity, not asthma control, is worse in atopic compared with nonatopic adolescents with asthma via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 7 November 2015 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Whitney D. Arroyave, Felicia A. Rabito, John C. Carlson, Michelle L. Sever, John Lefante BackgroundThe effects of atopic and nonatopic asthma phenotypes on asthma morbidity are unclear. Moreover, asthma morbidity in patients without atopy might be mediated by immunoglobulin E (IgE).ObjectiveTo determine dif... περισσότερα »

Role of extracellular vesicles in autoimmune diseases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Role of extracellular vesicles in autoimmune diseases via Autoimmunity Reviews Publication date: Available online 7 November 2015 *Source:*Autoimmunity Reviews Author(s): Delphine Turpin, Marie-Elise Truchetet, Benjamin Faustin, Jean-François Augusto, Cécile Bordes, Alain Brisson, Patrick Blanco, Pierre Duffau Extracellular vesicles (EVs) consist of exosomes released upon fusion of multivesicular bodies with the cell plasma membrane and microparticles shed directly from the cell membrane of many cell types. EVs can mediate cell-cell communication and are involved in many processes incl... περισσότερα »

Autoimmune Progesterone Dermatitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

: Update and Insights via Autoimmunity Reviews Publication date: Available online 7 November 2015 *Source:*Autoimmunity Reviews Author(s): Tegan Nguyen, A. Razzaque Ahmed Autoimmune progesterone dermatitis (APD) is rare autoimmune hypersensitivity reaction to the fluctuations of endogenous progesterone during a woman’s menstrual cycle. It has a wide spectrum of clinical presentations including urticaria, eczema and vesiculobullous eruptions. The disease course depends on treatment modality. The pathogenic mechanisms of APD remain to be elucidated.ObjectiveWe aim to review the literatur... περισσότερα »

Haemaphysalis longicornis tick bites are a possible cause of red meat allergy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan: Abstract Recent studies revealed that *Amblyomma* or *Ixodes* tick bites may cause red meat allergy, in which galactose-α-1,3-galactose (α-Gal) is a major IgE-binding epitope. The incidence of red meat allergy is high in Shimane prefecture, as is tick-transmitted Japanese spotted fever. Therefore, we speculated that tick bites may cause these meat allergies. The carbohydrate α-Gal was detected in the salivary gland protein of *Haemaphysalis longicornis (H. longicornis),* the vector for Japanese ...περισσότερα »

Possible Mechanism of Action of the Antiallergic Effect of an Aqueous Extract of Heliotropium indicum L. in Ovalbumin-Induced Allergic Conjunctivitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Possible Mechanism of Action of the Antiallergic Effect of an Aqueous Extract of Heliotropium indicum L. in Ovalbumin-Induced Allergic Conjunctivitis: Heliotropium indicum is used traditionally as a remedy for conjunctivitis in Ghana. This study therefore evaluated the antiallergic potential of an aqueous whole plant extract of Heliotropium indicum (HIE) in ovalbumin-induced allergic conjunctivitis and attempted to predict its mode of action. Clinical scores for allergic conjunctivitis induced by intraperitoneal ovalbumin sensitization (100 : 10 μg OVA/Al(OH)3 in phosphate-buffered ... περισσότερα »

Allergen immunotherapy in pregnancy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Allergen immunotherapy in pregnancy: Background: Allergic diseases such as asthma and allergic rhinitis constitute a significant burden of disease among women of childbearing age and those who are pregnant. Adequately managing these conditions is paramount in reducing negative fetal outcomes as well as maternal complications during pregnancy. However, the potential for harm to both the mother and fetus demands carefully balancing efficacy and safety of treatment. Allergen immunotherapy (AIT) has emerged as a relatively safe and efficacious mode of therapy in both children and adults. A...περισσότερα »

Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Abstract Introduction TP53 gene is the most frequently altered tumor suppressor gene in breast cancer. It has been observed that MDM2 plays a central role in regulating the TP53 pathway. This study aimed to investigate the role of TP53 Arg72Pro and MDM2 T309G polymorphisms in breast cancer patients. Material and method The TP53 (Arg72Pro) and MDM2 (T309G) polymorphisms were studied in a hospital-based case control study by AS-PCR in 100 breast cancer patients and 100 healthy control subjects. Results It was observed that TP53 Arg72Pro polymorphism was significantly associated wi... περισσότερα »

Intracranial venous sinus thrombosis as a complication of otitis media in children: critical review of diagnosis and management

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Intracranial venous sinus thrombosis as a complication of otitis media in children: critical review of diagnosis and management: Otogenic lateral sinus thrombosis (LST) is a rare intracranial complication of acute otitis media (AOM), which can lead to severe neurological sequelae and death. The aim of this study was to analyze the clinical presentation, management and outcome of LST in children, investigating a possible correlation between clinical aspects, radiological findings and anatomical variations.

Tympanostomy Tube Placement in Awake, Unrestrained Pediatric Patients: A Prospective, Multicenter Study

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Tympanostomy Tube Placement in Awake, Unrestrained Pediatric Patients: A Prospective, Multicenter Study: Tympanostomy tube (tube) placement is the most common pediatric otolaryngologic surgery in the United States. Most surgeries are performed in an operating-room setting under general anesthesia due to the lack of tolerable and reliable local anesthesia methods suitable for pediatric patients, and concerns regarding myringotomy procedures in a mobile child. This study evaluated the safety and efficacy of an iontophoresis system (IPS) to achieve local anesthesia in combination with ...περισσότερα »

Improved Behavior after Adenotonsillectomy In Children with Higher and Lower IQ

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Improved Behavior after Adenotonsillectomy In Children with Higher and Lower IQ: To examine whether high intellectual ability, in comparison to average or lower performance, reflects the consequences of sleep-disordered breathing and limits behavioral benefit observed 6 months after adenotonsillectomy.

Comparison of Effects of Pulsed Electromagnetic Field Stimulation on Platelet-Rich Plasma and Bone Marrow Stromal Stem Cell Using Rat Zygomatic Bone Defect Model

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Comparison of Effects of Pulsed Electromagnetic Field Stimulation on Platelet-Rich Plasma and Bone Marrow Stromal Stem Cell Using Rat Zygomatic Bone Defect Model: [image: image]Background: Reconstruction of bone defects that occur because of certain reasons has an important place in plastic and reconstructive surgery. The objective of the treatments of these defects was to reinstate the continuity of tissues placed in the area in which the defect has occurred. In this experimental study, the effect of pulsed electromagnetic field stimulation on platelet-rich plasma (PRP) and bone ma...περισσότερα »

Serum adenosine deaminase activity in thyroid disorders

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Serum adenosine deaminase activity in thyroid disorders: *Rajendra Duwal, Seraj Ahmed Khan, Binod Kumar Lal Das, Basanta Gelal* Thyroid Research and Practice 2015 12(3):104-106 Context: It has been widely reported that thyroid gland is very much prone to autoimmune disorder. Adenosine deaminase (ADA), an enzyme distributed in the human tissues, is considered as nonspecific marker of cell-mediated immunity. Also it is suggested to be an important enzyme for modulating the bioactivity of thyroid hormones, but its clinical significance in thyroid disorders is not yet characterized.... περισσότερα »

Developmental anomalies of thyroid: Thyroglossal duct cyst associated with ectopic thyroid: Radiology and nuclear medicine imaging findings

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Developmental anomalies of thyroid: Thyroglossal duct cyst associated with ectopic thyroid: Radiology and nuclear medicine imaging findings: *Sunita Nitin Sonavane, Mangala Targe Munde, Biju Menon, Ramesh Asopa* Thyroid Research and Practice 2015 12(3):119-123 We report a case of euthyroid young female with anterior midline neck swelling, non-tender gradually increased to present size since childhood. On anatomic cross sectional imaging ultrasonography (USG) and computed tomography (CT) scan showed multiseptated cyst in the midline neck, infrahyoid region with absent thyroid gla...περισσότερα »

Pharmacoeconomics of treatment options for hyperthyroidism: The Ibadan experience

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Pharmacoeconomics of treatment options for hyperthyroidism: The Ibadan experience: *Karounwi Omotayo Ogunjobi, John Enyi Ejeh, Aduragbenro Deborah Adedapo, Kayode Solomon Adedapo* Thyroid Research and Practice 2015 12(3):100-103 Objective: Hyperthyroidism is treated with anti-thyroid drugs (ATD), radioactive iodine and surgery. Debate is ongoing over which treatment option is better in terms of producing long term remission and production of fewer side effects. The cost of each option must be considered as well. Therefore, in this study, we analyzed the outcome and actual cost o...περισσότερα »

Thyroid ectopia: A case series and literature review

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Thyroid ectopia: A case series and literature review: *Madhuri Patil, Vageesh Ayyar, Ganapathi Bantwal, Anantha Raman, Belinda George, Vivek Mathew* Thyroid Research and Practice 2015 12(3):110-115 Thyroid ectopia is a dysgenesis of thyroid gland. A series of seventeen patients with ectopic thyroid tissue and dyshormonogenesis is presented here. Patient data were reviewed retrospectively for this descriptive study. At presentation, age of the patients ranged from 2 months to 50 years (mean age -13.7 yr). Male to female ratio is 1: 7.5. Hypothyroidism is present in 94.1% cases w... περισσότερα »

Children with autoimmune thyroiditis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Thyroid dysfunction and autoantibodies in first degree relatives of North Indian children with autoimmune thyroiditis: *Devi Dayal, Sanjeev H Naganur, Biman K Siakia, Baljinder Singh* Thyroid Research and Practice 2015 12(3):96-99 Background: Family studies in developed countries show an increased prevalence of thyroid autoantibodies in first degree relatives of children with autoimmune thyroiditis (AIT). Such data is scarce from developing country setups. Materials and Methods: Thyroid profiles and autoantibodies were evaluated in 50 first degree relatives of 50 children with A... περισσότερα »

Thyroid function and metabolic syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Thyroid function and metabolic syndrome: *Pankaj Agarwal, Mohit Mohan Singh, Manish Gutch* Thyroid Research and Practice 2015 12(3):85-86 The prevalence of metabolic syndrome varies around the world. In general, the prevalence of metabolic syndrome increases with age. The highest recorded prevalence worldwide is in Native Americans, with nearly 60% of women ages 45-49 and 45% of men ages 45-49 meeting the National Cholesterol Education Program and Adult Treatment Panel III (NCEP: ATP III) criteria. [1] Almost 30 − 65% of adult urban Indians are either overweight or obese or hav... περισσότερα »

Pattern and frequency of thyroid pathologies among thyroid cytology specimen in rural part

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Pattern and frequency of thyroid pathologies among thyroid cytology specimen in rural part of central India: A retrospective secondary data analysis: *Vivek Gupta, Arvind Bhake, Seema Dayal* Thyroid Research and Practice 2015 12(3):93-95 Background: Thyroid nodules are very frequent, with an annual incidence rate of 4-8%. Thyroid fine needle aspiration cytology (FNAC) is more than 50 years old and is the principal method of preoperative diagnosis in both children and adults. Aims: (1) To assess the pattern and frequency of thyroid lesions in cytology, (2) To study the correlatio... περισσότερα »

Levothyroxine replacement before glucocorticoid replacement leading to adrenal crisis in a case of autoimmune polyendocrine syndrome type II (Schmidt syndrome)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Levothyroxine replacement before glucocorticoid replacement leading to adrenal crisis in a case of autoimmune polyendocrine syndrome type II (Schmidt syndrome): *Om J Lakhani, Sudhir Tripathi, KC Indu, Mitali Desai* Thyroid Research and Practice 2015 12(3):116-118 Autoimmune polyendocrine syndrome II (APS II) is defined as Primary adrenal insufficiency with Autoimmune hypothyroidism and/or Type 1 Diabetes. Hypothyroidism is commonly diagnosed but adrenal insufficiency often gets missed out. Levothyroxine replacement before glucocorticoid replacement in a patient APS II can lead ... περισσότερα »

Low serum free and total tri-iodothyronine hormones as possible prognostic factors in liver cirrhotic patients due to chronic hepatitis C

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Low serum free and total tri-iodothyronine hormones as possible prognostic factors in liver cirrhotic patients due to chronic hepatitis C: *AbdAllah Ahmed El-Sawy, Mohamed Abd El-Raouf Tawfik* Thyroid Research and Practice 2015 12(3):87-92 Background and Aim: Liver and thyroid hormones are powerfully correlated so thyroid hormone abnormalities are seen in patients of liver diseases We evaluated serum thyroid hormone levels in chronic hepatitis C cirrhotic patients with and without hepatic encephalopathy. Patients and Methods: Our study was carried out on one hundred patients wit...περισσότερα »

Phosphate binders bind levothyroxine and affect the control of hypothyroidism

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Phosphate binders bind levothyroxine and affect the control of hypothyroidism: *Akihito Tanaka, Yuichi Ito* Thyroid Research and Practice 2015 12(3):124-125 Sir, The number of patients who receive regular hemodialysis (HD) is increasing. Among the HD patients, many patients show excessive high levels of phosphate and are administered phosphate binders, such as calcium carbonate (CaCO 3 ), sevelamer hydrochloride (SevHCl), lanthanum carbonate (LaCO 3 ) and so on. On the other hand, hypothyroidism is often seen. Complication of hypothyroidism in HD patients is not rare. Thyroid r... περισσότερα »

Hypothyroidism after hemithyroidectomy for colloid goiter: Is it a reality

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Hypothyroidism after hemithyroidectomy for colloid goiter: Is it a reality: *Karan Gupta, Naresh K Panda, Prachi Jain, Jaimanti Bakshi, Roshan Verma* Thyroid Research and Practice 2015 12(3):107-109 Objective: The objective was to determine the overall risk of hypothyroidism (clinical and subclinical) after hemithyroidectomy for colloid goiter. Materials and Methods: Prospective review of 54 patients who underwent hemithyroidectomy for colloid goiter at a tertiary care center from January, 2010 to December, 2012 with regular follow-up. Results: A total of 54 patients were includ... περισσότερα »

Evaluation of systemic inflammatory responses in cholecystectomy by means of access. Single-port umbilical incision, transvaginal NOTES, laparoscopy and laparotomy

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE: To evaluate and compare clinical and inflammatory responses to the surgical trauma caused by cholecystectomy via several access approaches: single-port umbilical incision (SILS), transvaginal natural orifice transluminal endoscopic surgery (NOTES), laparoscopy, and Laparotomy.METHODS: Twenty-eight female pigs were equally divided into four groups and submitted to cholecystectomy by single-port umbilical incision, transvaginal NOTES, laparoscopy, or Laparotomy. An additional five animals served as controls (sham group). Animals were monitored perioperatively regarding anes... περισσότερα »

Evaluation of intraluminal pressure in cystorrhaphies with and without intestinal serosal patch supplementation from canine cadavers

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE:To evaluate the maximal intraluminal pressure (MIP) supported by canine cadaveric urinary bladders that underwent cystotomy followed by cystorraphy, with and without serosal patching-supplementation.METHODS:Two groups (n=8 each) were formed, and in one (conventional) the cystotomy was closed with cushing pattern. In the other group (serosal), the same procedure was performed, and a piece of jejunum was used for the construction of the serosal patching over the cystorraphy. MIP was measured by means of an invasive blood pressure transducer with closed stopcock attached to a... περισσότερα »

Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in rats

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE:To evaluate the effect of ischemic postconditioning(IPC) on intestinal mucosa of rats subjected to ischemia and reperfusion process comparing two cycles of reperfusion and ischemia lasting two minutes each and four cycles of reperfusion and ischemia lasting 30 seconds eachMETHODS: Thirty Wistar rats were distributed into three groups: group A (10 rats), ischemia (30 minutes) and reperfusion (60 minutes); group B (10 rats), ischemia and reperfusion plus IPC by two lasting two minutes each; and Group C (10 rats), ischemia and reperfusion plus IPC by four cycles lasting 30 se...περισσότερα »

Comparative study of collagen deposition in the colon wall of patients operated for sigmoid diverticular disease

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

PURPOSE: To investigate the deposition of collagen in the colon wall of patients with sigmoid diverticulitis.METHODS: Samples of sigmoid tissue from 15 patients (disease group), seven men and eight women aged 37-77 years who underwent surgery for the treatment of diverticulitis, were selected. For the control group, specimens from five patients, three men and two women aged 19-58 years undergoing emergency surgery for sigmoid trauma were selected. These subjects had no associated diseases. The histological study of the surgical specimens was performed by staining with hematoxylin-...περισσότερα »

Comparison of Body, Auricular, and Abdominal Acupuncture Treatments for Insomnia Differentiated as Internal Harassment of Phlegm-Heat Syndrome: An Orthogonal Design

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Objective. To identify the optimum treatment protocol for insomnia among auricular, body, and abdominal needling methods. Methods. A three-factor (3 needling protocols) and three-level experimental scheme was designed based on orthogonal method. 54 patients of insomnia differentiated as internal harassment of phlegm-heat syndrome were given two courses of acupuncture treatment (each with 20 times of acupuncture). The therapeutic effects were evaluated by comparing the Pittsburgh sleep quality index (PSQI), Hamilton Depression Scale (HAMD) scores, and Hamilton Anxiety Scale (HAMA) s...περισσότερα »

Methylprednisolone Pulse Treatment of Graves' Ophthalmopathy Is Not Associated with Secondary Adrenocortical Insufficiency

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Methylprednisolone Pulse Treatment of Graves' Ophthalmopathy Is Not Associated with Secondary Adrenocortical Insufficiency: *Objective:* Graves' ophthalmopathy (GO) is an inflammatory disease in the orbital region. The first-line medical treatment is glucocorticoids. An important potential side effect of glucocorticoid treatment is suppression of the hypothalamic-pituitary-adrenal (HPA) axis with impairment of endogenous cortisol production, implicating symptoms of adrenocortical insufficiency, especially in the period after cessation of therapy with possible risks in cases of inter...περισσότερα »

Outcome of Subclassification of Indeterminate (Thy-3) Thyroid Cytology into Thy-3a and Thy-3f

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Outcome of Subclassification of Indeterminate (Thy-3) Thyroid Cytology into Thy-3a and Thy-3f: *Objectives:* The British Thy system is a widely used classification system for reporting thyroid fine-needle aspiration (FNA) cytology. The Royal College of Pathologists in 2009 recommended the subdivision of the Thy-3 (indeterminate) category into Thy-3a (atypia) and Thy-3f (follicular neoplasm). Our objective was to examine the malignancy rates of Thy-3a and Thy-3f cases at our institution and to investigate whether the risk of malignancy in Thy-3a cases is reduced by FNA on a different... περισσότερα »

Da Vinci single site© surgical platform in clinical practice: a systematic review

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Da Vinci single site© surgical platform in clinical practice: a systematic review: Abstract Background The Da Vinci single-site© surgical platform (DVSSP) is a set of single-site instruments and accessories specifically dedicated to robot-assisted single-site surgery. Methods The PubMed database from inception to June 2015 was searched for English literature on the clinical use of DVSSP in general surgery, urology and gynecology. Results Twenty-nine articles involving the clinical application of DVSSP were identified; 15 articles on general surgery (561 procedures), four articles o... περισσότερα »

Effekt der mikrochirurgischen Entfernung von Vestibularisschwannomen auf das Schmeckvermögen

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Effekt der mikrochirurgischen Entfernung von Vestibularisschwannomen auf das Schmeckvermögen: Laryngo-Rhino-Otol DOI: 10.1055/s-0035-1559679 Patienten mit Vestibularisschwannom berichten neben den bekannten Kardinalsymptomen auch über Schmeckstörungen. Wenig ist bisher zu diesem Symptom bei dieser Patientengruppe bekannt. Ziel dieser Untersuchung war es, den Einfluss der operativen Therapie auf das Schmeckvermögen mit Hilfe eines standardisierten Schmecktests prospektiv zu untersuchen. Dafür wurde das Schmeckvermögen mit den Schmeckstreifen vor und nach der Operation eines VS unte... περισσότερα »

Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2: AbstractSLC44A2 (solute carrier 44a2), also known as CTL2 (choline transporter-like protein 2), is expressed in many supporting cell types in the cochlea and is implicated in hair cell survival and antibody-induced hearing loss. In mice with the mixed C57BL/6-129 background, homozygous deletion of *Slc44a2* exons 3–10 (*Slc44a2* Δ/Δ) resulted in high-frequency hearing loss and hair cell death. To reduce effects associated with age-related hearing l... περισσότερα »

Tuning to Binaural Cues in Human Auditory Cortex

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Tuning to Binaural Cues in Human Auditory Cortex: AbstractInteraural level and time differences (ILD and ITD), the primary binaural cues for sound localization in azimuth, are known to modulate the tuned responses of neurons in mammalian auditory cortex (AC). The majority of these neurons respond best to cue values that favor the contralateral ear, such that contralateral bias is evident in the overall population response and thereby expected in population-level functional imaging data. Human neuroimaging studies, however, have not consistently found contralaterally biased binaural... περισσότερα »

Temporal Considerations for Stimulating Spiral Ganglion Neurons with Cochlear Implants

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Temporal Considerations for Stimulating Spiral Ganglion Neurons with Cochlear Implants: AbstractA wealth of knowledge about different types of neural responses to electrical stimulation has been developed over the past 100 years. However, the exact forms of neural response properties can vary across different types of neurons. In this review, we survey four stimulus-response phenomena that in recent years are thought to be relevant for cochlear implant stimulation of spiral ganglion neurons (SGNs): refractoriness, facilitation, accommodation, and spike rate adaptation. Of these fou... περισσότερα »

Face and content validity of a virtual-reality simulator for myringotomy with tube placement

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Face and content validity of a virtual-reality simulator for myringotomy with tube placement: Background: Myringotomy with tube insertion can be challenging for junior Otolaryngology residents as it is one of the first microscopic procedures they encounter. The Western myringotomy simulator was developed to allow trainees to practice microscope positioning, myringotomy, and tube placement. This virtual-reality simulator is viewed in stereoscopic 3D, and a haptic device is used to manipulate the digital ear model and surgical tools.ObjectiveTo assess the face and content validity of t... περισσότερα »

Surgeon-performed ultrasound guided fine-needle aspirate biopsy with report of learning curve; a consecutive case-series study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Surgeon-performed ultrasound guided fine-needle aspirate biopsy with report of learning curve; a consecutive case-series study: Background: Fine-needle aspiration biopsy has become the standard of care for the evaluation of thyroid nodules. More recently, the use of ultrasound guided fine-needle aspiration biopsy (UG-FNAB) has improved adequacy of sampling. Now there has been improved access to UG-FNAB as ultrasound technology has become more accessible. Here we review the adequacy rate and learning curve of a single surgeon starting at the adoption of UG-FNAB into surgical practice....περισσότερα »

Outcome analysis of 215 patients with parotid gland tumors: a retrospective cohort analysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Outcome analysis of 215 patients with parotid gland tumors: a retrospective cohort analysis: Background: To identify prognostic factors in patients with parotid gland carcinomas who were treated at the Princess Margaret Hospital. Methods: Clinical outcome of two hundred fifteen patients with malignancies of the parotid gland was evaluated over a 16-year period. Results: Two-hundred-fifteen patients with adenoid cystic carcinoma (n = 20), adenocarcinoma (n = 19), acinic cell carcinoma (n = 62), basal cell adenocarcinoma (n = 7), carcinoma-ex-pleomorphic adenoma (n = 18), mucoepidermoid...περισσότερα »

3-phase dual-energy CT scan as a feasible salvage imaging modality for the identification of non-localizing parathyroid adenomas: a prospective study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

3-phase dual-energy CT scan as a feasible salvage imaging modality for the identification of non-localizing parathyroid adenomas: a prospective study: ObjectivesAccurate pre-operative imaging of parathyroid adenomas (PAs) is essential for successful minimally invasive surgery; however, rates of non-localizing PAs can be as high as 18 %. Multiphasic dual-energy CT (DECT) has the potential to increase accuracy of PA detection by enabling creation of paired material maps and spectral tissue characterization. This study prospectively evaluated the utility of 3-phase DECT for PA identifi... περισσότερα »

Algorithm based patient care protocol to optimize patient care and inpatient stay in head and neck free flap patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Algorithm based patient care protocol to optimize patient care and inpatient stay in head and neck free flap patients: ObjectiveTo determine if rigid adherence (where medically appropriate) to an algorithm/checklist-based patient care pathway can reduce the duration of hospitalization and complication rates in patients undergoing head and neck reconstruction with free tissue transfer. Methods: Study design was a retrospective case-control study of patients undergoing major head and neck cancer resections and reconstruction at a tertiary referral centre. The intervention was rigid adh... περισσότερα »

The usefulness of routine histopathology of bilateral nasal polyps – a systematic review, meta-analysis, and cost evaluation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

The usefulness of routine histopathology of bilateral nasal polyps – a systematic review, meta-analysis, and cost evaluation: Background: Controversy regarding the usefulness of routine histopathological examination of bilateral nasal polyps removed during endoscopic sinus surgery to identify occult diagnoses still exists. There is a paucity of high-level evidence in the literature. Methods: A systematic review and meta-analysis was conducted. Two independent reviewers were used. Pooled proportions and numbers needed to screen were calculated. A cost per life year model was generated ... περισσότερα »

The Allen’s test: revisiting the importance of bidirectional testing to determine candidacy and design of radial forearm free flap harvest in the era of trans radial endovascular access procedures

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

The Allen’s test: revisiting the importance of bidirectional testing to determine candidacy and design of radial forearm free flap harvest in the era of trans radial endovascular access procedures: Background: The radial forearm free flap is a workhorse free flap. The radial artery, which supplies it, is increasingly being used for endovascular access. A complication of this is radial artery occlusion. Although often asymptomatic it can compromise future free tissue transfer.Case PresentationTwo patients who underwent RFFF harvest for head and neck reconstruction are presented; both ...περισσότερα »

Differentiated thyroid cancer in children and adults

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

“Clinicopathological features and treatment outcomes of differentiated thyroid cancer in Saudi children and adults”: IntroductionAge is an important prognostic factor in differentiated thyroid cancer (DTC). Our aim was to evaluate differences in clinicopathological features and treatment outcomes among children and adult patients with DTC.Materials and methodsWe studied 27 children (below 18 years) with DTC treated during the period 2000–2012 and were compared with (a) 78 adults aged 19–25 years and (b) 52 adults aged 26–30 years treated during the same period in terms of their clin...περισσότερα »

Malignant Transformation Rate in Patients Presenting Oral Epithelial Dysplasia: Systematic Review and Meta-Analysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Malignant Transformation Rate in Patients Presenting Oral Epithelial Dysplasia: Systematic Review and Meta-Analysis: Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observational studies. Quality assessments were completed by two reviewers indepen... περισσότερα »

Recurrence of Skull Base Meningiomas: The Role of Aggressive Removal in Surgical Treatment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Recurrence of Skull Base Meningiomas: The Role of Aggressive Removal in Surgical Treatment: J Neurol Surg B DOI: 10.1055/s-0035-1566251 Objectives The recurrence of meningiomas is a crucial aspect that must be considered during the planning of treatment strategy. The Simpson grade classification is the most relevant surgical aspect to predict the recurrence of meningiomas. We report on a series of patients with recurrent skull base meningiomas who were treated with the goal of radical removal. Design A retrospective study. Setting Hospital Ernesto Dornelles, Porto Alegre, Brazil. Pa...περισσότερα »

Factors Associated with Low Socioeconomic Status Predict Poor Postoperative Follow-up after Meningioma Resection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Factors Associated with Low Socioeconomic Status Predict Poor Postoperative Follow-up after Meningioma Resection: J Neurol Surg B DOI: 10.1055/s-0035-1566122 Objectives To quantify the rates of loss of follow-up after meningioma resection and to identify any key demographical associations. Design Retrospective cohort. Setting Vanderbilt University Medical Center, 2001–2013. Participants A total of 281 patients surgically treated for an intracranial meningioma at a single institution between 2001 and 2013. Main Outcome Measures Patient clinical follow-up within the first postoperative...περισσότερα »

Subtemporal Retrolabyrinthine (Posterior Petrosal) versus Endoscopic Endonasal Approach to the Petroclival Region: An Anatomical and Computed Tomography Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Subtemporal Retrolabyrinthine (Posterior Petrosal) versus Endoscopic Endonasal Approach to the Petroclival Region: An Anatomical and Computed Tomography Study: J Neurol Surg B DOI: 10.1055/s-0035-1566123 Background The petroclival region seats many neoplasms. Traditional surgical corridors to the region can result in unacceptable patient morbidity. The combined subtemporal retrolabyrinthine transpetrosal (posterior petrosal) approach provides adequate exposure with hearing preservation; however, the facial nerve and labyrinth are put at risk. Approaching the petroclival region wit... περισσότερα »

Morphometric Analysis of Bone Resection in Anterior Petrosectomies

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Morphometric Analysis of Bone Resection in Anterior Petrosectomies: J Neurol Surg B DOI: 10.1055/s-0035-1566301 Introduction The anterior petrosectomy is a well-defined skull base approach to lesions such as petroclival meningiomas, posterior circulation aneurysms, petrous apex lesions (chondrosarcomas, cholesteatomas), ventrolateral brainstem lesions, clival chordomas, trigeminal neurinomas, and access to cranial nerves III, IV, V, and VII. Methods and Materials Fourteen anterior petrosectomies on eight cadaveric heads were performed in a skull base dissection laboratory. Predissec...περισσότερα »

Individualized Surgical Approach Planning for Petroclival Tumors Using a 3D Printer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Individualized Surgical Approach Planning for Petroclival Tumors Using a 3D Printer: J Neurol Surg B DOI: 10.1055/s-0035-1566253 Objectives To determine the utility of three-dimensional (3D) printed models in individualized petroclival tumor resection planning by measuring the fidelity of printed anatomical structures and comparing tumor exposure afforded by different approaches. Design Case series and review of the literature. Setting Tertiary care center. Participants Three patients with petroclival lesions. Main Outcome Measures Subjective opinion of access by neuro-otologists and...περισσότερα »

Preoperative cytological diagnosis of papillary cystic variant of acinic cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Preoperative cytological diagnosis of papillary cystic variant of acinic cell carcinoma: A key consideration in patient management: *Sonali S Datar, Sandhya V Poflee, Nandu P Pande, Pradeep S Umap* Journal of Cytology 2015 32(3):191-193 Preoperative diagnosis of malignant salivary gland tumors is difficult as radiological imaging procedures have low sensitivity rate for detecting malignancy in parotid gland tumors. With careful and detailed analysis of cytological features, guided fine needle aspiration cytology can prove to be a reliable diagnostic modality that can help in dif... περισσότερα »

Histoplasmosis presenting as isolated cervical lymphadenopathy: A rare presentation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Histoplasmosis presenting as isolated cervical lymphadenopathy: A rare presentation: *Debi Prasad Mishra, Sindhu Ramamurthy, Samir Kumar Behera* Journal of Cytology 2015 32(3):188-190 Histoplasmosis is an opportunistic fungal infection caused by inhaling the spores of a fungus called Histoplasma capsulatum. Disseminated histoplasmosis is the most common form associated with acquired immune deficiency syndrome (AIDS). Here, we report a case of histoplasmosis presenting as isolated cervical lymphadenopathy in a human immunodeficiency virus (HIV)-infected patient diagnosed by a les... περισσότερα »

Pleomorphic lipoma is a relatively rare adipocytic neoplasm, occurring predominantly in elderly males in the subcutaneous tissues of the neck or shoulder

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Pleomorphic lipoma: A gentle giant of pathology: *Uma Sakhadeo, Rajesh Mundhe, Maria A DeSouza, Roshan F Chinoy* Journal of Cytology 2015 32(3):201-203 Pleomorphic lipoma is a relatively rare adipocytic neoplasm, occurring predominantly in elderly males in the subcutaneous tissues of the neck or shoulder. To the best of our knowledge, only five cases have been reported in which the lesion was intramuscular. We hereby report a case of a 60-year-old female patient, presenting with an intramuscular, posterior shoulder mass. The aspirate showed a giant cell-rich lesion, admixed with...περισσότερα »

Calvarial tuberculosis presenting as cystic lesion: An unusual presentation in two patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Calvarial tuberculosis presenting as cystic lesion: An unusual presentation in two patients: *Pratima Khare, Renu Gupta, Priyanka Chand, Swapnil Agarwal* Journal of Cytology 2015 32(3):176-180 Tuberculosis is a common disease in developing countries such as India, posing a major public health problem. With human immunodeficiency virus (HIV) infection being a global endemic, there has been a resurgence of tuberculosis even in developed countries. Tuberculosis may affect almost any part of the body. However, tuberculosis of the calvarium is very rare. Presentation of tuberculosis... περισσότερα »

Ovarian granulosa cell tumor metastatic to supraclavicular lymph node after 15 years of diagnosis: A case report

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Ovarian granulosa cell tumor metastatic to supraclavicular lymph node after 15 years of diagnosis: A case report: *Shailja Puri, Neha Mohindroo, Shobha Mohindroo, Sudarshan Sharma* Journal of Cytology 2015 32(3):213-214 Sir, Supraclavicular lymph node metastasis can originate from the head and neck primarily, and also from infraclavicular sites such as breast, lung, and cervix. [1] Gastric carcinomas characteristically metastasize to the left supraclavicular lymph node, called Virchow's node. Ovarian malignancies are an uncommon primary site for metastasis to the supraclavicula... περισσότερα »

Computer-assisted surgery and intraoral welding technique for immediate implant-supported rehabilitation of the edentulous maxilla: case report and technical description

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 18 ώρες

Computer-assisted surgery and intraoral welding technique for immediate implant-supported rehabilitation of the edentulous maxilla: case report and technical description: Abstract Background Complications are frequently reported when combining computer assisted flapless surgery with an immediate loaded prefabricated prosthesis. The authors have combined computer-assisted surgery with the intraoral welding technique to obtain a precise passive fit of the immediate loading prosthesis. Methods An edentulous maxilla was rehabilitated with four computer assisted implants welded together...περισσότερα »

Identifying Musical Difficulties as they Relate to Congenital Amusia in the Pediatric Population

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Identifying Musical Difficulties as they Relate to Congenital Amusia in the Pediatric Population: Approximately 4% of the population fails to develop basic music skills and can be identified as “amusic”. Congenital amusia (CA), or “tone deafness”, is thought to be a hereditary disordera predominantly affecting the perception and production of music. The gold standard for diagnosis is the Montreal Battery for Evaluation of Amusia (MBEA). This study aims to pinpoint factors in the history that may help identify amusic children and to determine if amusic pediatric patients can be ident... περισσότερα »

Anti-PD-1/PD-L1 Therapy as a Promising Option for Non-Small Cell Lung Cancer: a Single arm Meta-Analysis

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Abstract Anti-PD-1/PD-L1 antibodies showed satisfactory efficacy in treating non-small-cell lung cancer. We conducted this meta-analysis to explore the advantage subtypes and best therapeutic modalities of Anti-PD-1/PD-L1 therapy on NSCLC. A quantitative meta-analysis was performed through a systematic search in PubMed, Web of Science, and the Cochrane Library. The pooled ORR, 6-month progression-free survival rate (PFSR6m), and 1-year overall survival rate (OSR1y) were calculated and compared. 15 trials were included in this meta-analysis. Our analyses demonstrated the pooled ORR ...περισσότερα »

Contribution of EVX1 in Aggressiveness of Esophageal Squamous Cell Carcinoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 18 ώρες

Abstract Homeobox genes play an overruling role in the regional cell fate determination during development. *EVX*1 is known as a new target gene of BMP signaling pathway, a group of morphogens which are making the largest subset within the transformation growth factor beta (TGF-β) superfamily. In this study, we aimed to enlighten the expression level of *EVX1* in esophageal squamous cell carcinoma (ESCC) and to disclose its apparent roles in maintenance and progression of the disease. The expression level of *EVX1* was analyzed in fresh tumoral tissues in comparison with distant t...περισσότερα »

Melanoma Research

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Diagnostic value of MRI and computed tomography in anorectal malignant melanoma. Here, we report 12 cases of anorectal malignant melanoma (ARMM), which has a very rare incidence. Patients were examined by either computed tomography or MRI or computed tomography combined with MRI before they underwent a remission operation. Because of the paramagnetic contribution from melanin, the short T1 and short T2 signals in MRI were specific to melanoma. MRI is reliable in the early diagnosis of ARMM, which is confirmed by pathological reports. Therefore, we advocate the application of a radiol... περισσότερα »

Pediatric Auditory Brainstem Implant Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Pediatric Auditory Brainstem Implant Surgery: Auditory brainstem implants (ABIs) provide auditory perception in patients with profound hearing loss who are not candidates for the cochlear implant (CI) because of anatomic constraints or failed CI surgery. Herein, the authors discuss (1) preoperative evaluation of pediatric ABI candidates, (2) surgical approaches, and (3) contemporary ABI devices and their use in the pediatric population. The authors also review the surgical and audiologic outcomes following pediatric ABI surgery. The authors’ institutional experience and the nearly 2... περισσότερα »

Swallowing outcome measures in head and neck cancer – How do they compare?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Swallowing outcome measures in head and neck cancer – How do they compare?: Dysphagia is the most common long term side effect of chemoradiotherapy (CRT) treatment for head and neck cancer (HNC) [1]. Swallowing ability is a priority issue for patients [1] and is associated with higher risk of pneumonia, poorer oral intake, prolonged tube feeding, weight loss as well as fundamental changes to eating patterns, social activities and consequently poorer quality of life [2,3]. In light of this, much work is now focused towards finding predictors of post-treatment dysphagia, developing re... περισσότερα »

Prediction model to predict critical weight loss in patients with head and neck cancer during (chemo)radiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Prediction model to predict critical weight loss in patients with head and neck cancer during (chemo)radiotherapy: Patients with advanced head and neck cancer (HNC) frequently experience weight loss, often already before diagnosis, as well as during and after treatment [1–4]. Weight loss is one of the main symptoms of malnutrition. Malnutrition is a subacute or chronic state in which a combination of varying degrees of undernutrition and inflammatory activity has led to a change in body composition and diminished function [5]. It is associated with a higher risk of complications, le... περισσότερα »

Epstein–Barr virus LMP1 induces focal adhesions and epithelial cell migration through effects on integrin-α5 and N-cadherin

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Epstein–Barr virus LMP1 induces focal adhesions and epithelial cell migration through effects on integrin-α5 and N-cadherin: *Epstein–Barr virus LMP1 induces focal adhesions and epithelial cell migration through effects on integrin-α5 and N-cadherin* Oncogenesis 4, e171 (October 2015). doi:10.1038/oncsis.2015.31 Authors: L R Wasil & K H Y Shair Abstract Epstein–Barr virus (EBV) is a γ-herpesvirus associated with human epithelial and B-cell malignancies. The EBV latent membrane protein (LMP) 1 is expressed in nasopharyngeal carcinoma (NPC) and promotes oncogenic intracellular s... περισσότερα »

A novel BRD4-NUT fusion in an undifferentiated sinonasal tumor highlights alternative splicing as a contributing oncogenic factor in NUT midline carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

A novel BRD4-NUT fusion in an undifferentiated sinonasal tumor highlights alternative splicing as a contributing oncogenic factor in NUT midline carcinoma: *A novel BRD4-NUT fusion in an undifferentiated sinonasal tumor highlights alternative splicing as a contributing oncogenic factor in NUT midline carcinoma* Oncogenesis 4, e174 (November 2015). doi:10.1038/oncsis.2015.33 Authors: A Stirnweiss, K McCarthy, J Oommen, M L Crook, K Hardy, U R Kees, S D Wilton, A Anazodo & A H Beesley A Stirnweiss1, K McCarthy2, J Oommen1, M L Crook3, K Hardy4, U R Kees1, S D Wilton5, A Anazodo... περισσότερα »

Esophageal Neoplasm : Endodrill vs. Conventional Biopsy. Diagnostics and Genetic Analysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Endodrill vs. Conventional Biopsy. Diagnostics and Genetic Analysis: *Condition*: Esophageal Neoplasm *Interventions*: Device: Endodrill Biopsy; Device: Conventional Biopsy forceps *Sponsor*: Region Skane *Not yet recruiting* - verified November 2015 ArmsAssigned InterventionsActive Comparator: Conventional biopsy 4 out of 8 biopsies taken with a conventional biopsy forceps from the tumor tissue in the distal esophagus and cardia. The biopsies will be taken in random order "blinded" for the person performing the examination. 1 additional biopsy will be taken from the tum... περισσότερα »

Der Einsatz der perkutanen Dilatationstracheotomie im Rahmen der Kopf-Hals-Tumorchirurgie

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Der Einsatz der perkutanen Dilatationstracheotomie im Rahmen der Kopf-Hals-Tumorchirurgie: Laryngo-Rhino-Otol DOI: 10.1055/s-0035-1555915 Hintergrund: Im Rahmen der chirurgischen Therapie von Kopf-Hals-Tumoren stellt die peri- und postoperative Atemwegssicherung eine klinisch relevante, anspruchsvolle Aufgabe dar. Meistens wird ein epithelisiertes Tracheostoma angelegt. Der Stellenwert der perkutanen Dilatationstracheotomie (PDT) in Kombination mit tumorchirurgischen Eingriffen des Kopf-Hals-Bereiches ist bisher nicht geklärt. Material und Methoden: Im Zeitraum von Dezember 2002 bi... περισσότερα »

Evaluation eines Klassifikationsmodells horizontaler Gefäßveränderungen der Stimmlippen

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Evaluation eines Klassifikationsmodells horizontaler Gefäßveränderungen der Stimmlippen: Laryngo-Rhino-Otol DOI: 10.1055/s-0035-1559677 Hintergrund: Derzeit existiert keine valide Klassifikation von beginnenden Gefäßveränderungen der Stimmlippen. Wir testeten deshalb ein neues Klassifikationsmodell sichtbarer, beginnender, vaskulärer Veränderungen der Stimmlippen. Material und Methoden: 3 Gutachtern wurden 168 indirekte larynxendoskopische Aufnahmen der Stimmlippen als 84 Weißlicht-(WL) und 84 Narrow-Band-Imaging-Bilder (NBI) in zufälliger Reihenfolge zur Klassifikation vorgelegt ...περισσότερα »

Spektrografische Stimmtypenklassifizierung zur Beurteilung der Stimmqualität

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Spektrografische Stimmtypenklassifizierung zur Beurteilung der Stimmqualität: Laryngo-Rhino-Otol DOI: 10.1055/s-0035-1559678 Hintergrund: Neben der auditiv-perzeptiven Beurteilung, zählen auch objektiv-akustische Methoden als valides Evaluationsmittel für die Beurteilung der Stimmqualität. Die Spektrografie wird seit ca. 50 Jahren eingesetzt und kürzlich wurde ein neues Verfahren zur spektrografischen Stimmtypenklassifizierung nach Sprecher et al. (2010) vorgestellt. Das Ziel dieser Studie ist die Überprüfung der externen Validität beider Messverfahren mit einer größeren Stimmenan... περισσότερα »

Therapie von Blutungen bei Patienten unter oraler Antikoagulation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Therapie von Blutungen bei Patienten unter oraler Antikoagulation: Laryngo-Rhino-Otol 2015; 94: 697-709 DOI: 10.1055/s-0034-1564071 Sowohl unter einer Therapie mit klassischen Antikoagulanzien wie auch unter den direkten oralen Antikoagulanzien sind Blutungen die wichtigste klinische Komplikation. Deren Therapie unterscheidet sich zwischen den Substanzgruppen erheblich.

Die Sinusvenenthrombose – eine seltene Komplikation der akuten Mastoiditis und des Cholesteatoms

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Die Sinusvenenthrombose – eine seltene Komplikation der akuten Mastoiditis und des Cholesteatoms: Laryngo-Rhino-Otol DOI: 10.1055/s-0035-1555914 Hintergrund: Die Sinusvenenthrombose (SVT) ist eine seltene Komplikation der akuten Mastoiditis und des infizierten Cholesteatoms. In der internationalen Literatur wurde bisher wenig über die systematische Untersuchung bei V.a. eine SVT dokumentiert. In dieser Untersuchung wurden die klinischen, intraoperativen und therapeutischen Befunde der Patienten diskutiert. Patienten und Methoden: Es werden retrospektiv 7 Patienten mit radiologisc... περισσότερα »

Mucosal CD30-Positive T-Cell Lymphoproliferative Disorder Arising in the Oral Cavity Following Dental Implants

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 18 ώρες

Mucosal CD30-Positive T-Cell Lymphoproliferative Disorder Arising in the Oral Cavity Following Dental Implants: Report of the First Case: Mucosal CD30-positive T-cell lymphoproliferative disorder (CD30+ T-cell LPD) is a novel entity with unique clinicopathological features and an indolent behavior. Here we report the first case of mucosal CD30+ T-cell LPD arising in the oral cavity following dental implant. A 70-year-old woman presented with swelling and redness of the oral mucosa of right maxilla and left mandible surrounding dental implants that had been placed 8 years previously... περισσότερα »

Shikonin Inhibits Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts via lncRNA-NR024118

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Background. Shikonin is a major chemical component of zicao that possesses anti-inflammatory properties and the ability to mediate cellular and humoral immunity, especially in rheumatoid arthritis (RA). We investigated the impact of shikonin on inflammatory response in RA synovial fibroblasts using the CAIA model. Methods. Severe polyarticular arthritis was induced in Balb/c female mice. Expressions of lncRNA-NR024118, SOCS3, proinflammatory cytokines, and MMPs were evaluated using RT-RCR. Histone acetylation and SOCS3 protein expression were assessed by ChIP assay and western blo...περισσότερα »

Vaccines, Vol. 3, Pages 940-972: Live-Attenuated Bacterial Vectors: Tools for Vaccine and Therapeutic Agent Delivery

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 ώρες

Genetically attenuated microorganisms, including pathogenic and commensal bacteria, can be engineered to carry and deliver heterologous antigens to elicit host immunity against both the vector as well as the pathogen from which the donor gene is derived. These live attenuated bacterial vectors have been given much attention due to their capacity to induce a broad range of immune responses including localized mucosal, as well as systemic humoral and/or cell-mediated immunity. In addition, the unique tumor-homing characteristics of these bacterial vectors has also been exploited for ... περισσότερα »

Effects of a novel magnetic orthopedic appliance (MOA-III) on the dentofacial complex in mild to moderate skeletal class III children

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 18 ώρες

Effects of a novel magnetic orthopedic appliance (MOA-III) on the dentofacial complex in mild to moderate skeletal class III children: IntroductionThe objective of this study was to evaluate the changes of skeletal and dental structures in mild to moderate skeletal Class III children following the use of a new magnetic orthopedic appliance (MOA-III). Methods: A total of 36 patients (14 boys and 22 girls, mean age 9 years and 5 months) who presented with a mild to moderate skeletal Class III jaw discrepancy were treated with MOA-III. Another group of 20 untreated patients (9 boys and ... περισσότερα »

Effect of submucosal application of tramadol on postoperative pain after third molar surgery

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 18 ώρες

Effect of submucosal application of tramadol on postoperative pain after third molar surgery: The aim of this study was to evaluate the effectiveness of submucosal application of tramadol, for acute postoperative facial pain, following the extraction of impacted third molar teeth. This prospective, double-blind, randomised placebo-controlled study included 60 ASA I-II patients undergoing impacted third molar surgery under local anaesthesia. Following the surgical procedure, patients were randomly divided into two groups; group T (1 mg/kg tramadol) and group S (2-mL saline). Treatmen... περισσότερα »

High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma: Background. Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. Objective. To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained from patients who underwent thyroid surgery. Methods. Data of thyroid nodules obtained from 1,638 patients who underwent thyroid surgery were evaluated. Thyroid autoimmunity was ...περισσότερα »

Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination: Background. Elevated cytokines levels correlate with sepsis severity and mortality but their role in the diagnosis is controversial, whereas Procalcitonin (PCT) has been largely used. Recently, the mid-regional proadrenomedullin (MR-proADM) has been combined with PCT for diagnosis optimization. In this study the combined measurement of PCT, MR-proADM, and cytokines in patients with sepsis was evaluated. Methods. One hundred and four septic patients and 101 controls w... περισσότερα »

An Epstein-Barr Virus (EBV)-Based NPC Screening Project

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Evaluation of the Sensitivity of Endoscopy to Detect Nasopharyngeal Carcinoma (NPC) in an Epstein-Barr Virus (EBV)-Based NPC Screening Project in China: *Condition*: Nasopharyngeal Cancinoma (NPC) *Intervention*: *Sponsor*: National Cancer Institute (NCI) *Not yet recruiting* - verified October 2015 Background: Epstein-Barr virus (EBV) can cause the cancer nasopharyngeal carcinoma (NPC). Early detection of NPC through screening can lead to better treatment outcomes than when it is found later. Currently, NPC is found through visual inspection with an endoscope. It is not ... περισσότερα »