Evaluation of adverse events in atomic bomb survivors receiving curative-intent radiation therapy from 2005 to 2010

Publication date: Available online 19 December 2015
Source:Radiotherapy and Oncology
Author(s): Yoshiko Doi, Yuji Murakami, Masahiro Kenjo, Nobuki Imano, Tomoki Kimura, Yasushi Nagata
Background and purposeTo evaluate the safety of radiation therapy (RT) in atomic bomb (A-bomb) survivors (ABS), we evaluated the frequency of RT-associated adverse events (AEs) in ABS.Materials and methodsWe selected patients who underwent curative external-beam RT (EBRT) at Hiroshima University Hospital between January 2005 and December 2010 and were born before August 1946; the patients were divided into ABS and non-ABS groups, which groups received identical treatments without stratification.ResultsWe retrospectively reviewed the medical records of 220 ABS and 753 non-ABS patients. The median age was 72years. The median observation durations were 41 and 37months for the ABS and non-ABS groups, respectively. The ABS group had higher frequencies of women, breast cancer patients, and concurrent chemotherapy and had a lower incidence of only acute hematological AEs. However this tendency disappeared when breast cancer patients were excluded, and no significant differences were observed between the ABS and non-ABS groups regarding Grade⩾3 other acute and late AEs. The overall cumulative incidence of Grade⩾3 late AEs did not significantly differ between the ABS and non-ABS groups.ConclusionsNotable increases in AEs were not observed during or after RT among ABS. This study clarified that stratification is not required when treating ABS with RT.



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