Invasive, atypical and aggressive pituitary adenomas and carcinomas.

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Invasive, atypical and aggressive pituitary adenomas and carcinomas.

Endocrinol Metab Clin North Am. 2015 Mar;44(1):99-104

Authors: Sav A, Rotondo F, Syro LV, Di Ieva A, Cusimano MD, Kovacs K

Abstract
Aggressive pituitary adenomas have a high risk of recurrence, a lack of therapeutic response, and resistance to conventional treatment. So far, no satisfactory biomarkers are available for predicting their behavior. Some specific pituitary adenoma histotypes are more prone to follow an aggressive behavior. Pituitary carcinomas are rare and show cerebrospinal and/or systemic metastasis. They have worse prognosis than aggressive adenomas, and radiation is of limited use in their treatment.

PMID: 25732646 [PubMed - indexed for MEDLINE]

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