Long-term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

Publication date: Available online 24 December 2015 Source:Cancer Cell Author(s): Tikvah K. Hayes, Nicole F. Neel, Chaoxin Hu, Prson Gautam, Melissa Chenard, Brian Long, Meraj Aziz, Michelle Kassner, Kirsten L. Bryant, Mariaelena Pierobon, Raoud Marayati, Swapnil Kher, Samuel D. George, Mai Xu, Andrea Wang-Gillam, Ahmed A. Samatar, Anirban Maitra, Krister Wennerberg, Emanuel F. Petricoin, Hongwei H. Yin, Barry Nelkin, Adrienne D. Cox, Jen Jen Yeh, Channing J. Der Induction of compensatory mechanisms and ERK reactivation has limited the effectiveness of Raf and MEK inhibitors in RAS-mutant cancers. We determined that direct pharmacologic inhibition of ERK suppressed the growth of a subset of KRAS-mutant pancreatic cancer cell lines and that concurrent pho…

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