Atopic dermatitis is not associated with actinic keratosis: cross-sectional results from the Rotterdam study

Abstract

Background

Epidermal barrier impairment and altered immune system in atopic dermatitis (AD) may predispose to ultraviolet induced DNA damage.

Objective

To study the association between atopic dermatitis and actinic keratosis (AK) in a population-based cross-sectional study.

Methods

AD was defined by modified criteria of the U.K. working party's diagnostic criteria. The AKs were diagnosed by physicians during a full-body skin examination and keratinocyte cancers were identified via linking to the national pathology database. The results were analysed in adjusted multivariable and multinomial models.

Results

Lower proportion of subjects with AD had AKs than without AD (16% vs 24%, p=0.002; unadjusted OR 0.60; 95% CI, 0.42-0.83, adjusted 0.74; 95% CI, 0.51-1.05, fully adjusted 0.69; 95 CI, (0.47-1.07)). In a multinomial model AD patients were less likely to have 10 or more AKs (adjusted OR 0.28; 95% CI, 0.09-0.90). No effect of AD on BCC and SCC was found (adjusted OR 0.71; 95% CI, 0.41-1.24 and adjusted OR 1.54; 95% CI, 0.66-3.62).

Conclusion

AD in community dwelling patients is not associated with AK.

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