Long term comparison of rib and ear cartilage grafts in autologous and allogenic fascia lata - an experimental study in a white rabbit model.

Background: Diced cartilage in fascia grafts (DCF) have become the material of choice for dorsal grafts in rhinoplasty. Allogenic fascia lata has not yet been investigated as isolated fascial graft or as a combined graft with ear and rib cartilage, especially in comparison to autologous fascia and over a long implantation period. Methods: 10 different grafts were built from either autologous or allogenic fascia lata alone or as DCFs with diced costal or ear cartilage and implanted into the dorsal skin of 15 rabbits. After 3 or 9 months the grafts were explanted and histologically analysed. Chondrocytes and cartilage matrix characteristics, calcification, ossification, formation of bone marrow, fibrosis ingrowth and fibrotic transformation, the presence of immune reactions, vascular ingrowth, regenerative capacity and capsule formation was examined in a semi quantitative manner. Results: All grafts were vital and without inflammatory response. The cartilage showed regular nuclei, a normal matrix and regenerative capacity. A higher grade of calcification and ossification was observed in the fascia/cartilage grafts than in isolated cartilage grafts and more pronounced for costal cartilage. Both types of fascia were shown to be equally stable and without degradation. There were no significant differences in the DCF grafts built with autologous compared to allogenic fascia. Conclusion: This study shows the equivalency of DCFs and isolated fascial grafts using allogenic fascia lata compared to autologous fascia. The type of used cartilage accounts for different long term characteristics of DCF grafts. (C)2016American Society of Plastic Surgeons

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