Posterior Fossa Intra-axial Tumors in Adults.

Posterior Fossa Intra-axial Tumors in Adults.

World Neurosurg. 2015 Dec 29;

Authors: Grossman R, Ram Z

Abstract
BACKGROUND: The posterior fossa is the site of many types of tumors, and brain metastases are the most common malignancies in that location among adults. Other brain tumors, such as ependymomas, medulloblastomas and juvenile pilocytic astrocytomas, mostly occur during childhood and are relatively rare in the adult population. The majority of primary malignant brain tumors, such as gliomas and lymphomas, tend to be located in the supratentorial compartment.
METHODS: In this review we summarized the current data including prognostic factors and therapeutic management and molecular data of patients with intra-axial posterior fossa tumors in adults including ependymomas, medulloblastomas pilocytic astrocytomas in the "posterior fossa in adults.
RESULTS: We present the literature on intra-axial posterior fossa tumors in adults that relies mainly on limited retrospective clinical studies and employing a wide range of treatment approaches that were usually based on therapies developed specifically for children or for supratentorial brain tumors CONCLUSIONS: The clinical course and surgical outcome of adult patients with intra-axial brain tumors in the posterior fossa is summarized in this review. The prognostic factors and therapeutic management of patients with these tumors are controversial due to their rarity, their heterogeneity and the lack of sufficient data in the literature.

PMID: 26743385 [PubMed - as supplied by publisher]

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