Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma Expresses High Hydrogen Sulfide Synthesizing Enzymes

Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) is associated with a positive therapeutic response compared to HPV-negative SCC that tumors often result from alcohol and tobacco exposures. The reason for the better prognosis is currently unknown, although a wild-type/less mutated p53 gene status in HPV-positive tumors may play a role. The HPV E6 protein causes the degradation of miRNA34a, an event known to increase nicotinamide phosphoribosyltransferase (Nampt) levels. (Source: International Journal of Radiation Oncology * Biology * Physics)

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