IMPORTANCE OF SERATONIN GENE RELATED PEPTIDE (SGRP) IN MIGRAINE

2016-02-21T11-56-54Z
Source: International Journal of Health and Rehabilitation Sciences (IJHRS)
Sivanandan Ramar, Sankaran Ponnusamy, Salameh Al Dajah.
Migraine is a neurovascular disorder involving trigeminal ganglion characterized by recurrent episodic headache and rise in levels of Serotonin Gene Related Protein (SGRP) in plasma. SGRP is a neuropeptide present in the central and peripheral nervous system that has diverse functions as primary afferent neurotransmitter which is important in nociception. In this study expression of SGRP studied in neurons of trigeminal ganglion in male wistar albino rats. SGRP is expressed in cytoplasm of neurons mainly in the small sized neurons indicating that small sized neurons are mainly involved in nociception. Keyword:.


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