Publication date: Available online 30 January 2016
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Éder Ricardo Biasoli, Vitor Bonetti Valente, Bruna Mantovan, Francisco Urbano Collado, Sebastião Conrado Neto, Maria Lúcia Marçal Mazza Sundefeld, Glauco Issamu Miyahara, Daniel Galera Bernabé
PurposeThere are few clinical studies focusing on the lip cancer treatment outcomes. This study aims to investigate the clinicopathological variables profile of a large sample of lip squamous cell carcinoma (LSCC) patients treated in a head and neck cancer reference center for the last 25 years, and to analyze the influence of these variables on the treatment outcomes.Materials and MethodsIn this retrospective cohort study, we reviewed the clinical records of LSCC patients. The epidemiological data were age, gender, ethnicity, type of occupation, tobacco smoking, alcohol consumption, comorbid conditions and family cancer history. Clinicopathological features included the lip location of the tumor, TNM classification, clinical staging, histopathological grade, surgical margin analysis and treatment modality. Local recurrence, second primary tumor and survival were the outcome variables. Statistics was performed by Chi-square, Fisher exact test and Binary Logistic Regression. Survival analysis was assessed through the Kaplan and Meier curve. Level of statistical significance was set at p<0.05 for all tests.ResultsA total of 144 LSCC patients were studied. There were 117 men (81.25%) and 27 women (18.75%), with mean age of 60.21 years. One hundred thirty-four patients (93.05%) were considered of white ethnicity and in 57 cases (39.58%) the patients presented an occupation that was related to chronic solar exposure. Most cancers had initial clinical staging of I/II (84.02%). Microscopically, lesions were predominantly well- (43.05%) and moderately- (40.96%) differentiated tumors. The clinical staging was related to a specific higher survival rate (p=0.0049). One hundred twelve cases (77.78%) were submitted to surgical treatment and only six patients (4.80%) had local recurrence, which was directly associated with compromised surgical margins (p=0.0320).ConclusionA high success rate in LSCC treatment was observed in this study. Compromised surgical margin was associated to tumor recurrence and is a critical event in lip cancer treatment.
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Éder Ricardo Biasoli, Vitor Bonetti Valente, Bruna Mantovan, Francisco Urbano Collado, Sebastião Conrado Neto, Maria Lúcia Marçal Mazza Sundefeld, Glauco Issamu Miyahara, Daniel Galera Bernabé
PurposeThere are few clinical studies focusing on the lip cancer treatment outcomes. This study aims to investigate the clinicopathological variables profile of a large sample of lip squamous cell carcinoma (LSCC) patients treated in a head and neck cancer reference center for the last 25 years, and to analyze the influence of these variables on the treatment outcomes.Materials and MethodsIn this retrospective cohort study, we reviewed the clinical records of LSCC patients. The epidemiological data were age, gender, ethnicity, type of occupation, tobacco smoking, alcohol consumption, comorbid conditions and family cancer history. Clinicopathological features included the lip location of the tumor, TNM classification, clinical staging, histopathological grade, surgical margin analysis and treatment modality. Local recurrence, second primary tumor and survival were the outcome variables. Statistics was performed by Chi-square, Fisher exact test and Binary Logistic Regression. Survival analysis was assessed through the Kaplan and Meier curve. Level of statistical significance was set at p<0.05 for all tests.ResultsA total of 144 LSCC patients were studied. There were 117 men (81.25%) and 27 women (18.75%), with mean age of 60.21 years. One hundred thirty-four patients (93.05%) were considered of white ethnicity and in 57 cases (39.58%) the patients presented an occupation that was related to chronic solar exposure. Most cancers had initial clinical staging of I/II (84.02%). Microscopically, lesions were predominantly well- (43.05%) and moderately- (40.96%) differentiated tumors. The clinical staging was related to a specific higher survival rate (p=0.0049). One hundred twelve cases (77.78%) were submitted to surgical treatment and only six patients (4.80%) had local recurrence, which was directly associated with compromised surgical margins (p=0.0320).ConclusionA high success rate in LSCC treatment was observed in this study. Compromised surgical margin was associated to tumor recurrence and is a critical event in lip cancer treatment.
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